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Journal of Viral Hepatitis

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https://www.readbyqxmd.com/read/27917600/determination-of-hepatitis-b-phenotype-using-biochemical-and%C3%A2-serological-markers
#1
A M Di Bisceglie, M Lombardero, J Teckman, L Roberts, H L A Janssen, S H Belle, J H Hoofnagle
The aim of this study was to assess the validity of categorization of chronic hepatitis B viral infection into stages or phases based upon measures of disease activity and viral load, assuming these phenotypes will be useful for prognostication and determining the need for antiviral therapy. We assessed the phenotype of hepatitis B of 1,390 adult participants enrolled in the Hepatitis B Research Network Cohort Study, using a computer algorithm. Only 4% were immune tolerant, while 35% had chronic hepatitis B (18% e antigen positive and 17% e antigen negative) while 23% were inactive carriers...
December 5, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27917597/chronic-hepatitis-c-infection-and-liver-disease-in-hiv-coinfected-patients-in-asia
#2
N Durier, E Yunihastuti, K Ruxrungtham, N V Kinh, A Kamarulzaman, D Boettiger, A Widhani, A Avihingsanon, B V Huy, S F B Syed Omar, A Sanityoso, S Chittmittrapap, N T H Dung, V Pillai, T Suwan-Ampai, M Law, A H Sohn, G Matthews
Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan(®) ) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7-42.5) years, 365 (76...
December 5, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27917563/outcome-of-hepatitis-b-and-c-virus-associated-hepatocellular-carcinoma-occurring-after-renal-transplantation
#3
N Kanaan, C Raggi, E Goffin, M De Meyer, M Mourad, M Jadoul, C Beguin, B Kabamba, I Borbath, Y Pirson, Z Hassoun
Kidney transplant recipients (KTR) are subjected to immunosuppressive therapy that can enhance hepatitis B and C virus replication, leading to cirrhosis and hepatocellular carcinoma (HCC). The aim of this study was to assess the prevalence and outcome of HCC in KTR. Case-control study. Patients with chronic HBV and/or HCV infection who underwent kidney transplantation between 1976 and 2011 and subsequently developed HCC were compared to a control group of patients with chronic HBV and/or HCV infection, matched for gender and age at HCC diagnosis, who did not receive kidney transplantation...
December 5, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27905669/secondary-prophylaxis-of-hepatocellular-carcinoma-the-comparison-of-direct-acting-antivirals-with-pegylated-interferon-and-untreated-cohort
#4
R Vukotic, R Di Donato, F Conti, A Scuteri, C Serra, P Andreone
During the past two decades, several studies showed reduced rates of hepatocellular carcinoma recurrence in patients with HCV-related cirrhosis after interferon-based antiviral therapies respect to untreated controls, even without reaching viral clearance. The recent development of new all-oral regimens with direct-acting antivirals has radically improved the therapeutic management of hepatitis C. Nevertheless, paradoxical, or at least unexpected, high rates of both occurrence and recurrence of hepatocellular carcinoma after a treatment with direct-acting antivirals, have been reported in the recent literature...
December 1, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27905175/racial-disparity-in-all-cause-mortality-among-hepatitis-c-virus-infected-individuals-in-a-general-us-population-nhanes-iii
#5
B Emmanuel, M D Shardell, L Tracy, S Kottilil, S S El-Kamary
There are few long-term nationally representative studies of all-cause mortality among those infected with hepatitis C virus (HCV). When an additional 5 years of data were made publicly available in 2015, the Third National Health and Nutrition Examination Survey Linked Mortality File became the longest nationally representative study in the United States. Our objective was to update the estimated HCV-associated all-cause mortality in the general US population and determine any differences by sex, age and race/ethnicity...
December 1, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27905173/hepatitis-c-virus-genotype-4-genotype-1-s-little-brother
#6
REVIEW
J Llaneras, M Riveiro-Barciela, M Buti, R Esteban
Treatment for hepatitis C virus genotype 4 infection has undergone a major advance over the past 5 years with the emergence of direct-acting antiviral agents. Previously, genotype 4 treatment had been limited to the combination of pegylated interferon and ribavirin, with low rates of sustained virological response. The combinations of new direct-acting agents have resulted in a radical improvement in hepatitis C therapy. Much of the currently available efficacy and safety information in the treatment of genotype 4 has been extrapolated through the results of genotype 1...
December 1, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27891718/the-association-between-hepatitis-b-self-awareness-and-depression-exploring-the-modifying-effects-of-socio-economic-factors
#7
Y Liu, K Tang, J Long, C Zhao
China has a high prevalence of HBV. Despite previous studies, uncertainty remains about the association of HBV with depression. This study explores the strength of the association and the modifying effects of participants' self-awareness of the disease and their socio-economic status. Data from the baseline of a Chinese cohort study of approximately 500 000 adults were analysed. Depression was assessed using the Composite International Diagnostic Inventory. Blood spot tests were conducted to detect hepatitis B surface antigen...
November 28, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27891715/baseline-hepatitis-b-core-antibody-predicts-treatment-response-in-chronic-hepatitis-b-patients-receiving-long-term-entecavir
#8
J-H Xu, L-W Song, N Li, S Wang, Z Zeng, C-W Si, J Li, Q Mao, D-Z Zhang, H Tang, J-F Sheng, X-Y Chen, Q Ning, G-F Shi, Q Xie, Q Yuan, Y-Y Yu, N-S Xia
Studies regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) in patients with chronic hepatitis B receiving first-line nucleos(t)ide analogues is limited. The aim of this study was to determine the performance of anti-HBc as a predictor for hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with entecavir. This was a retrospective cohort study consisting of 139 Chinese patients enrolled in a multicenter clinical trial treated with entecavir or entecavir maleate for up to 240 weeks...
November 28, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27885757/role-of-primary-t-cell-immunodeficiency-and-hepatitis-b-coinfection-on-spontaneous-clearance-of-hepatitis-c-the-bc-hepatitis-testers-cohort
#9
N Islam, M Krajden, M Gilbert, P Gustafson, A Yu, M Kuo, M Chong, M Alvarez, J Wong, M W Tyndall, N Z Janjua
T-cell host immune response against hepatitis C virus (HCV) has been suggested to play an important role in determining HCV infection outcome. However, data from human studies are not available. This study examined the effect of primary T-cell deficiency along with other factors on the spontaneous clearance of HCV in a large population-based cohort in British Columbia, Canada. The BC Hepatitis Testers Cohort includes all individuals tested for HCV in BC in 1990-2013 linked with data on their medical visits, hospitalizations and prescription drugs...
November 25, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27885753/prognosis-of-1169-hepatitis-c-chronically-infected-patients-with-decompensated-cirrhosis-in-the-predirect-acting-antiviral%C3%A2-era
#10
S A McDonald, H A Innes, E Aspinall, P C Hayes, M Alavi, H Valerio, D J Goldberg, S J Hutchinson
At a population level, little is known regarding the risk of liver- and nonliver-related mortality and hospitalization and the development of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV)-infected patients with decompensated cirrhosis (DC). This large-scale national record-linkage study estimates these outcomes following first hospital admission for DC. Record-linkages between national HCV diagnosis and clinical databases and the national inpatient hospital episode database and mortality register were conducted to follow-up the disease course of all identified HCV-diagnosed and chronically infected persons...
November 25, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27885748/protective-efficacy-and-hepatitis-b-virus-clearance-in-mice-enhanced-by-cell-mediated-immunity-with-novel-prime-boost-regimens
#11
X Chuai, P Chen, H Chen, W Wang, Y Deng, L Ruan, W Li, W Tan
In this study, anti-hepatitis B virus (HBV) immunity was evaluated in mice using several regimens of the HBV recombinant protein vaccine HBSS1 that expressed in CHO cells containing S (1-223 aa) and preS1 (21-47 aa) and recombinant adenovirus rAdSS1 vaccine. Further, the protective efficacy of these vaccine regimens was studied in a mouse model. High titres of antigen-specific antibodies and neutralizing activity were elicited in mice after vaccination. However, robust multi-antigen (preS1 and S)-specific cell-mediated immunity (CMI) was only detected in mice primed with HBSS1 and boosted with rAdSS1...
November 25, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27882678/a-molecular-transmission-network-of-recent-hepatitis-c-infection-in-people-with-and-without-hiv-implications-for-targeted-treatment-strategies
#12
S R Bartlett, J O Wertheim, R A Bull, G V Matthews, F M J Lamoury, K Scheffler, M Hellard, L Maher, G J Dore, A R Lloyd, T L Applegate, J Grebely
Combining phylogenetic and network methodologies has the potential to better inform targeted interventions to prevent and treat infectious diseases. This study reconstructed a molecular transmission network for people with recent hepatitis C virus (HCV) infection and modelled the impact of targeting directly acting antiviral (DAA) treatment for HCV in the network. Participants were selected from three Australian studies of recent HCV from 2004 to 2014. HCV sequence data (Core-E2) from participants at the time of recent HCV detection were analysed to infer a network by connecting pairs of sequences whose divergence was ≤...
November 24, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27878906/simeprevir-daclatasvir-and-sofosbuvir-for-hepatitis-c-virus-infected-patients-with-decompensated-liver-disease
#13
E Lawitz, F Poordad, J A Gutierrez, T N Kakuda, G Picchio, G Beets, A Vandevoorde, P Van Remoortere, B Jacquemyn, D Luo, S Ouwerkerk-Mahadevan, L Vijgen, V Van Eygen, M Beumont
Approximately three million individuals in the United States are chronically infected with hepatitis C virus (HCV). Chronic HCV infection may lead to the development of compensated as well as decompensated liver cirrhosis. The Phase II IMPACT study was conducted in HCV genotype 1- or 4-infected cirrhotic patients with portal hypertension or decompensated liver disease and assessed for the first time the combination of the three direct-acting antivirals simeprevir, daclatasvir and sofosbuvir. Treatment-naïve or treatment-experienced adults with Child-Pugh (CP) score <7 (CP A) and evidence of portal hypertension, or CP score 7-9 (CP B), received 12 weeks of simeprevir 150 mg, daclatasvir 60 mg and sofosbuvir 400 mg, once daily...
November 23, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27860000/hepatitis-b-infection-is-associated-with-an-increased-incidence-of-thrombocytopenia-in-healthy-adults-without-cirrhosis
#14
E-J Joo, Y Chang, J-S Yeom, Y-G Lee, S Ryu
The association between HBV infection and incident thrombocytopenia among subjects without cirrhosis or splenomegaly is unknown. Therefore, we sought to elucidate the association between HBV infection and the development of thrombocytopenia in a large cohort of apparently healthy men and women. A cohort study was performed in 122 200 participants without liver cirrhosis or splenomegaly who underwent comprehensive health examinations and were followed until December 2014. HBV infection was defined by the presence of hepatitis B surface antigen (HBsAg) at baseline...
November 18, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27862671/usefulness-of-albumin-bilirubin-grade-for-evaluation-of-long-term-prognosis-for-hepatitis-b-related-cirrhosis
#15
R-C Chen, Y-J Cai, J-M Wu, X-D Wang, M Song, Y-Q Wang, M-H Zheng, Y-P Chen, Z Lin, K Q Shi
Long-term prognosis varies widely among patients with hepatitis B virus (HBV)-related liver cirrhosis. Our study aimed to investigate the applicability of albumin-bilirubin (ALBI), Child-Pugh and model for end-stage liver disease (MELD) scores to the long-term prognosis prediction of HBV-related cirrhosis. Patients diagnosed with HBV-associated cirrhosis from the First Affiliated Hospital of Wenzhou Medical University between January 2010 and December 2015 were enrolled in this study. The patients were followed up every 3 months...
November 14, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27862657/rapid-improvement-in-liver-fibrosis-in-hcv-infected-patients-with-or-without-hiv-infection-and-daa-induced-svr-a-turning-off-effect-of-liver-inflammation
#16
LETTER
G Bruno, A Saracino, C Fabrizio, L Scudeller, M Milella, G Angarano
No abstract text is available yet for this article.
November 14, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27862695/pan-genotypic-treatment-regimens-for-hepatitis-c-virus-advantages-and-disadvantages-in-high-and-low-income-regions
#17
REVIEW
C Hézode
During the last 5 years, the availability of direct-acting antiviral (DAA) agents has revolutionized the treatment of hepatitis C virus (HCV). Compared with interferon/ribavirin-the previous standard of care-DAA combination regimens offer improved sustained virological response (SVR) rates, shorter treatment durations of 8-24 weeks, convenient once-daily single-tablet formulations and more favourable tolerability profiles. HCV treatment is complex, and the choice of therapy must consider a complex range of factors, including baseline viral load, fibrosis stage, the HCV genotype and subgenotype, and the presence of resistance-associated substitutions at baseline...
November 9, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27813284/functional-connectivity-alterations-in-patients-with-chronic-hepatitis-c-virus-infection-a-multimodal-mri-study
#18
S Kharabian Masouleh, S Herzig, L Klose, E Roggenhofer, H Tenckhoff, T Kaiser, A Thöne-Otto, M Wiese, T Berg, M L Schroeter, D S Margulies, A Villringer
Chronic hepatitis C virus (HCV) infection is associated with fatigue and depression. Cognitive impairments are also reported in a smaller number of HCV-positive patients. Recent studies linked HCV to low-grade inflammation in brain. Here, we test the hypothesis that chronic HCV is associated with 3T-neuroimaging-derived grey matter volume (GMV) and functional connectivity alterations in a sample of chronic HCV (1b), without severe liver disease. Regional GMV and resting-state fMRI-derived eigenvector centrality (EC) were compared between 19 HCV-positive patients and 23 healthy controls (all females, 50-69 and 52-64 years, respectively), controlling for white matter hyperintensities and age...
November 4, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27808472/a-novel-hepatitis-b-virus-subgenotype-d10-circulating-in-ethiopia
#19
G B Hundie, V Stalin Raj, D Gebre Michael, S D Pas, M P Koopmans, A D M E Osterhaus, S L Smits, B L Haagmans
Hepatitis B virus (HBV) is genetically highly divergent and classified in ten genotypes and forty subgenotypes in distinct ethno-geographic populations worldwide. Ethiopia is a country with high HBV prevalence; however, little is known about the genetic variability of HBV strains that circulate. Here, we characterize the complete genome of 29 HBV strains originating from five Ethiopian regions, by 454 deep sequencing and Sanger sequencing. Phylogenetically, ten strains were classified as genotype A1 and nineteen as genotype D...
November 3, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27808453/phylogenetic-analysis-of-full-length-early-infection-hepatitis-c-virus-genomes-among-people-with-intravenous-drug-use-the-inc-3-study
#20
C Rodrigo, A A Eltahla, R A Bull, F Luciani, J Grebely, G J Dore, T Applegate, K Page, J Bruneau, M D Morris, A L Cox, W Osburn, A Y Kim, N H Shoukry, G M Lauer, L Maher, J Schinkel, M Prins, M Hellard, A R Lloyd
Cross-continental phylogenetic analysis is important to understand subtle molecular differences of currently circulating hepatitis C virus (HCV) subtypes. Existence of such differences can be crucial in pursuing a universal hepatitis C vaccine. We characterized molecular epidemiology of early HCV infections identified across nine cohorts [North America (n=4), Australia (n=4) and Europe (n=1)] in the International Collaborative of Incident HIV and Hepatitis C in Injecting Cohorts (InC(3) ). One hundred and ninety-two full-length HCV genomes were amplified from plasma of incident infections and subjected to next generation sequencing to establish the largest cross-continental, full-length acute HCV genomic data set available to date...
November 3, 2016: Journal of Viral Hepatitis
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