journal
MENU ▼
Read by QxMD icon Read
search

Microcirculation: the Official Journal of the Microcirculatory Society, Inc

journal
https://www.readbyqxmd.com/read/29432661/is-pulmonary-vascular-disease-reversible-with-ppar-%C3%A9-agonists
#1
Peter Afdal, Antoine F AbdelMassih
Severe angio-obliterative pulmonary vascular disease (PAH) remains a disease characterized by great morbidity and shortened survival. Unfortunately, the only currently available treatments for angio-obliterative changes are palliative in the form of pulmonary vasodilators evolving from the phosphodiesterase inhibitor sildenafil to endothelin receptor antagonist: Bosentan; while the only definitive treatment is lung transplantation which remains dependent on the availability of donors and the transplant policies which vary widely from a country to another...
February 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29412499/substance-p-ameliorates-tumor-necrosis-factor-alpha-induced-endothelial-cell-dysfunction-by-regulating-enos-expression-in-vitro
#2
Jiyuan Piao, Hyun Sook Hong, Youngsook Son
OBJECTIVE: The aim of the present study was to explore the beneficial effects of SP on NO production and inflammation-induced vascular endothelium cell death. METHODS: To mimic the inflammatory environment, tumor necrosis factor alpha (TNF-α) was treated to human umbilical vein endothelial cells (HUVECs), and SP was added prior to TNF-α to determine its protective effect. WST-1 assay was performed to detect cell viability. NO level in conditioned medium was measured by Griess Reagent system...
February 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29377443/salvinorin-a-ameliorates-cerebral-vasospasm-through-activation-of-endothelial-nitric-oxide-synthase-in-a-rat-model-of-subarachnoid-hemorrhage
#3
Juan Sun, Yan Zhang, Jianfei Lu, Weiguang Zhang, Junhao Yan, Lei Yang, Changman Zhou, Renyu Liu, Chunhua Chen
OBJECTIVES: This study aimed to demonstrate the potential of Salvinorin A (SA) for cerebral vasospasm after subarachnoid hemorrhage (SAH) and investigate mechanisms of therapeutic effect using rat SAH model. METHODS: SA was injected intraperitoneally and the neurobehavioral changes were observed at 24h, 48h and 72h after SAH. Basilar artery was observed by Magnetic Resonance Imaging (MRI). The inner diameter and thickness of basilar artery were measured. The morphological changes and the apoptosis in CA1 area of hippocampus were detected...
January 27, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29356218/brain-oxygenation-with-a-non-vasoactive-perfluorocarbon-emulsion-in-a-rat-model-of-traumatic-brain-injury
#4
Rania Abutarboush, Saad H Mullah, Biswajit K Saha, Ashraful Haque, Peter B Walker, Chioma Aligbe, Georgina Pappas, Lam Thuy Vi Tran Ho, Francoise G Arnaud, Charles R Auker, Richard M McCarron, Anke H Scultetus, Paula Moon-Massat
OBJECTIVE: The aim of this study was to assess, in two experiments, the safety and efficacy of the PFC emulsion Oxycyte as an oxygen therapeutic for traumatic brain injury (TBI) to test the hypothesis that early administration of this oxygen-carrying fluid post-TBI would improve brain tissue oxygenation (Pbt O2 ). METHODS: The first experiment assessed effects of Oxycyte on cerebral vasoactivity in healthy, uninjured rats using intravital microscopy. The second experiment investigated the effect of Oxycyte on cerebral Pbt O2 using the phosphorescence quenching method (PQM) in TBI model...
January 22, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29325214/a-spike-in-mechanotransductive-adenosine-triphosphate-release-from-red-blood-cells-in-microfluidic-constrictions-only-occurs-with-rare-donors
#5
J E Mancuso, W D Ristenpart
OBJECTIVE: Wan et al. (2008) demonstrated that RBCs rapidly and transiently release a spike of 300% more ATP shortly downstream from a short microfluidic constriction where the cells experience a sudden increase in shear stress. More recent work by Cinar et al. (2015), however, yielded no evidence for a similar spike in ATP release downstream of the constriction. Our aim was to determine if a transient spike in mechanotransduction is the typical response of red blood cells to the sudden onset of increased shear...
January 11, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29323451/microvascular-involvement-in-systemic-sclerosis-and-systemic-lupus-erythematosus
#6
Didem Saygin, Kristin Highland, Adriano R Tonelli
Microvascular changes play central roles in the pathophysiology of systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), and represent major causes of morbidity and mortality in these patients. Therefore, clinical tools that can assess the microvasculature are of great importance both at the time of diagnosis and follow up of these cases. These tools include capillaroscopy, laser imaging techniques, infrared thermography and iontophoresis. In this review, we examined the clinical manifestations and pathobiology of microvascular involvement in SSc and SLE as well as the methodologies used to evaluate the microvasculature...
January 11, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29285816/arterialized-collateral-capillaries-progress-from-non-reactive-to-capable-of-increasing-perfusion-in-an-ischemic-tree
#7
Kenneth H Gouin, Sara K Hellstrom, Lindsay E Clegg, Joshua Cutts, Feilim Mac Gabhann, Trevor R Cardinal
OBJECTIVE: Collateral capillary arteriogenenesis (CCA), outward remodeling of capillaries that anastomose two arteriolar trees with different parent feed arteries, may represent a therapeutic target for patients who lack collaterals. Arterialized collateral capillaries (ACCs) can reperfuse an ischemic tree, but their functional capacity is unknown. Therefore, we determined if ACCs mature into resistance vessels that regulate blood flow following arterial occlusion. METHODS: We ligated the lateral spinotrapezius feed artery in Balb/C mice, which induces CCA...
December 28, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29247493/the-yin-and-yang-of-kv-channels-in-cerebral-small-vessel-pathologies
#8
Masayo Koide, Arash Moshkforoush, Nikolaos M Tsoukias, David C Hill-Eubanks, George C Wellman, Mark T Nelson, Fabrice Dabertrand
Cerebral small vessel diseases (SVDs) encompass a group of genetic and sporadic pathological processes leading to brain lesions, cognitive decline, and stroke. There is no specific treatment for SVDs, which progress silently for years before becoming clinically symptomatic. Here, we examine parallels in the functional defects of parenchymal arterioles in CADASIL, a monogenic form of SVD, and in response to subarachnoid hemorrhage, a common type of hemorrhagic stroke that also targets the brain microvasculature...
December 15, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29247478/chinese-medicine-tongxinluo-capsule-alleviates-cerebral-microcirculatory-disturbances-in-ischemic-stroke-by-modulating-vascular-endothelial-function-and-inhibiting-leukocyte-endothelial-cell-interactions-in-mice-a-two-photon-laser-scanning-microscopy-study
#9
Shen Liu, Cong Wei, Ning Kang, Qilong He, Junqing Liang, Hongtao Wang, Liping Chang, Daohong Chen, Qiuyan Zhang, Chengcheng Chang, Junfang Zhang, Hong Ren, Yiling Wu
OBJECTIVE: The aim of this study was to examine the effect of Tongxinluo capsule (TXL), a Chinese medicine prescription, on cerebral microcirculatory disturbances after permanent middle cerebral artery occlusion (pMCAO) in mice using two-photon laser scanning microscopy (TPLSM) and further explore the underlying mechanisms. METHODS: C57BL/6J mice were subjected to pMCAO and orally administered with TXL (3.0, 1.5 and 0.75 g/kg/day) at 1h, 3h and 21h after pMCAO. The following parameters were examined at 6h and 24h after pMCAO: neurological deficit, infarct volume, blood-brain barrier (BBB) permeability, cerebral microvessel structure, brain microcirculation (TPLSM imaging), vasoactive factors and adhesion molecules...
December 15, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29239491/regulation-of-microvascular-function-by-voltage-gated-potassium-channels-new-tricks-for-an-ancient-dog
#10
Matthew A Nystoriak, Manuel F Navedo
Arterial tone is tightly regulated by a variety of potassium (K+ ) permeable ion channels at the sarcolemma of vascular smooth muscle cells. In particular, several types of voltage-gated K+ (KV ) channels provide a significant hyperpolarizing influence and serve to oppose pressure and agonist-induced membrane depolarization to promote smooth muscle relaxation and augmentation of vascular diameter and blood flow. In recent years, a number of studies have underscored previously unknown roles for particular KV subunits, new modes of channel regulation, and distinct cellular functions for these channels during physiological and pathological conditions...
December 14, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29211322/perivascular-adipose-tissue-and-the-dynamic-regulation-of-kv-7-and-kir-channels-implications-to-resistant-hypertension
#11
Maik Gollasch, Donald G Welsh, Rudolf Schubert
Resistant hypertension is defined as high blood pressure that remains uncontrolled despite treatment with at least three antihypertensive drugs at adequate doses. Resistant hypertension is an increasingly common clinical problem in older age, obesity, diabetes, sleep apnea, and chronic kidney disease. Although the direct vasodilator minoxidil was introduced in the early 1970s, only recently has this drug been shown to be particularly effective in a subgroup of patients with treatment-resistant or uncontrolled hypertension...
December 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29210138/endovascular-shedding-markers-in-patients-with-heart-failure-with-reduced-ejection-fraction
#12
Petra Nijst, Jirka Cops, Pieter Martens, Quirine Swennen, Matthias Dupont, W H Wilson Tang, Wilfried Mullens
BACKGROUND: Endothelial glycocalyx degradation has been associated with multiple pathophysiological processes in cardiovascular disease. AIMS: To explore the role of glycocalyx shedding markers in pathophysiology of heart failure with reduced ejection fraction (HFrEF). METHODS: In 123 HFrEF patients the concentration, prognostic value and association of glycocalyx shedding markers with other disease processes was investigated. RESULTS: Median hyaluronic acid (HA) levels and syndecan-1 levels in HFrEF patients were respectively 29...
December 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29210137/hyperoxia-does-not-affect-oxygen-delivery-in-healthy-volunteers-while-causing-a-decrease-in-sublingual-perfusion
#13
B Smit, Y M Smulders, E C Eringa, H P M M Gelissen, A R J Girbes, H J S de Grooth, H H M Schotman, P G Scheffer, H M Oudemans-van Straaten, A M E Spoelstra-de Man
To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in oxygen delivery and sublingual microcirculatory perfusion METHODS: Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20 kPa, 40 kPa, 60 kPa and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume-clamp method. At the end of each period, the sublingual microcirculation was assessed by Sidestream Darkfield Imaging RESULTS: Systemic oxygen delivery was unchanged throughout the study (Pslope =0...
December 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29161755/shaker-related-voltage-gated-k-channel-expression-and-vasomotor-function-in-human-coronary-resistance-arteries
#14
Yoshinori Nishijima, Ankush Korishettar, Dawid S Chabowski, Sheng Cao, Xiaodong Zheng, David D Gutterman, David X Zhang
OBJECTIVES: KV channels are important regulators of vascular tone, but the identity of specific KV channels involved and their regulation in disease remain less well understood. We determined the expression of KV 1 channel subunits and their role in cAMP-mediated dilation in coronary resistance arteries from subjects with and without CAD. METHODS: HCAs from patients with and without CAD were assessed for mRNA and protein expression of KV 1 channel subunits with molecular techniques and for vasodilator response with isolated arterial myography...
January 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29130567/treatment-strategies-in-coronary-microvascular-dysfunction-a-systematic-review-of-interventional-studies
#15
Hannah E Suhrs, Marie M Michelsen, Eva Prescott
Coronary microvascular dysfunction has been associated with a wide spectrum of diseases and conditions, and it has proven to be a strong prognostic marker of morbidity and mortality. Despite increased attention guideline-based treatment recommendations are lacking. We performed a systematic review of pharmacological and non-pharmacological interventions to improve coronary perfusion, assessed by intracoronary Doppler, transthoracic Doppler echocardiography, positron emission tomography, cardiac magnetic resonance imaging, transthoracic contrast perfusion echocardiography and dilution techniques...
November 11, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29117630/biophysical-properties-of-microvascular-endothelium-requirements-for-initiating-and-conducting-electrical-signals
#16
Adam Kapela, Erik J Behringer, Steven S Segal, Nikolaos M Tsoukias
OBJECTIVE: Electrical signaling along the endothelium underlies spreading vasodilation and blood flow control. We use mathematical modeling to determine the electrical properties of the endothelium and gain insight into the biophysical determinants of electrical conduction. METHODS: Electrical conduction data along endothelial cell (EC) tubes (40 μm wide, 2.5 mm long) isolated from mouse skeletal muscle resistance arteries were analyzed using cable equations and a multicellular computational model...
November 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29110409/coronary-microvascular-kv1-channels-as-regulatory-sensors-of-intracellular-pyridine-nucleotide-redox-potential
#17
Marc M Dwenger, Vahagn Ohanyan, Manuel F Navedo, Matthew A Nystoriak
Smooth muscle voltage-gated potassium (Kv) channels are important regulators of microvascular tone and tissue perfusion. Recent studies indicate that Kv1 channels represent a key component of the physiological coupling between coronary blood flow and myocardial oxygen demand. While the mechanisms by which metabolic changes in the heart are transduced to alter coronary Kv1 channel gating and promote vasodilation are unclear, a growing body of evidence underscores a pivotal role of Kv1 channels in sensing the cellular redox status...
November 7, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29110368/kv-channels-and-vascular-smooth-muscle-cells-proliferation
#18
José R López-López, Pilar Cidad, M Teresa Pérez-García
Kv channels are present in virtually all vascular smooth muscle cells (VSMC) and strongly influence contractile responses. However, they are also instrumental in the proliferative, migratory and secretory functions of synthetic, dedifferentiated VSMCs cells upon phenotypic modulation (PM). In fact, Kv channels not only contribute to all these processes but they are also active players in the phenotypic switch itself. This review is focused on the role(s) of Kv channels in VSMC proliferation, which is one of the best characterized functions of dedifferentiated VSMCs...
November 7, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29106775/oxygen-delivery-from-the-cerebral-microvasculature-to-tissue-is-governed-by-a-single-time-constant-of-approximately-6-seconds
#19
S J Payne, C Lucas
The cerebral microvasculature plays a key role in the coupling between cerebral blood flow and metabolism. Although experimental imaging techniques now allow for finely detailed measurements of flow and oxygenation, within humans measurements remain confined to a voxel level scale, of order 1 mm. Mathematical models are thus key in interpreting such data. However, these can be highly complicated, due to the large number of vessels and the non-linearities in the governing equations. We thus propose here a new model of the cerebral microvasculature and show how its behaviour can be simplified based on order of magnitude arguments...
November 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28801994/influence-of-feeding-hematocrit-and-perfusion-pressure-on-hematocrit-reduction-f%C3%A3-hraeus-effect-in-an-artificial-microvascular-network
#20
Walter H Reinhart, Nathaniel Z Piety, Sergey S Shevkoplyas
OBJECTIVE: Hct in narrow vessels is reduced due to concentration of fast-flowing RBCs in the center, and of slower flowing plasma along the wall of the vessel, which in combination with plasma skimming at bifurcations leads to the striking heterogeneity of local Hct in branching capillary networks known as the network Fåhraeus effect. We analyzed the influence of feeding Hct and perfusion pressure on the Fåhraeus effect in an AMVN. METHODS: RBC suspensions in plasma with Hcts between 20% and 70% were perfused at pressures of 5-60 cm H2 O through the AMVN...
November 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
journal
journal
32012
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"