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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://www.readbyqxmd.com/read/30481399/high-salt-diet-impairs-cerebral-blood-flow-regulation-via-salt-induced-angiotensin-ii-suppression
#1
Linda A Allen, James R Schmidt, Christopher T Thompson, Brian E Carlson, Daniel A Beard, Julian H Lombard
OBJECTIVES: This study sought to determine whether salt-induced angiotensin II suppression contributes to impaired cerebral blood flow (CBF) autoregulation. METHODS: Cerebral autoregulation was evaluated with laser-Doppler flowmetry during graded reductions of blood pressure. Autoregulatory responses in rats fed high salt (HS; 4% NaCl) diet vs low salt (LS; 0.4% NaCl) diet were analyzed using linear regression analysis, model-free analysis, and a mechanistic theoretical model of blood flow through cerebral arterioles...
November 27, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30480851/multifractal-and-lacunarity-analyses-of-microvascular-morphology-in-eyes-with-diabetic-retinopathy-a-projection-artifact-resolved-optical-coherence-tomography-angiography-study
#2
Tiepei Zhu, Jinlian Ma, Jinyu Li, Xizhe Dai, Panpan Ye, Zhaoan Su, Dexing Kong, Juan Ye
OBJECTIVE: To evaluate the degree of microvascular impairment in diabetic retinopathy using multifractal and lacunarity analyses and to compare the diagnostic ability between traditional Euclidean measures (fovea avascular zone area and vessel density) and fractal geometric features. METHODS: This retrospective cross-sectional study included a total of 143 eyes of 94 patients with different stages of diabetic retinopathy. The retinal microvasculature was imaged by projection removed optical coherence tomography angiography...
November 27, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30471168/skeletal-muscle-performance-in-metabolic-disease-microvascular-or-mitochondrial-limitation-or-both
#3
Jefferson C Frisbee, Matthew T Lewis, Robert W Wiseman
One of the clearly established health outcomes associated with chronic metabolic diseases (e.g., type II diabetes mellitus) is that the ability of skeletal muscle to maintain contractile performance during periods of elevated metabolic demand is compromised as compared to the fatigue-resistance of muscle under normal, healthy conditions. While there has been extensive effort dedicated to determining the major factors that contribute to the compromised performance of skeletal muscle with chronic metabolic disease, the extent to which this poor outcome reflects a dysfunctional state of the microcirculation, where the delivery and distribution of metabolic substrates can be impaired, versus derangements to normal metabolic processes and mitochondrial function, versus a combination of the two, represents an area of considerable unknown...
November 24, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30431204/effects-of-tumor-necrosis-factor-%C3%AE-induced-exosomes-on-the-endothelial-cellular-behavior-metabolism-and-bioenergetics
#4
Bingwei Li, Luhan Li, Qiuju Zhang, Honggang Zhang, Ruijuan Xiu
OBJECTIVE: To investigate the effects of TNF-α-induced exosomes release on the biological behavior, metabolism, and bioenergetics of HUVECs. METHODS: Exosomes were isolated from conditioned media of HUVECs by ultracentrifugation after treatment with or without TNF-α. HUVECs were treated with or without TNF-α, or different concentrations of exosomes isolated from conditioned media with or without TNF-α induction (TExo and CExo , respectively). RESULTS: The results showed that TNF-α significantly inhibited migration, tube formation, and increased apoptosis rate of HUVECs compared with controls...
November 15, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30431201/capillary-flow-disturbances-after-experimental-subarachnoid-hemorrhage-a-contributor-to-delayed-cerebral-ischemia
#5
Maryam Anzabi, Hugo Angleys, Rasmus Aamand, Maryam Ardalan, Kim Mouridsen, Peter Mondrup Rasmussen, Jens Christian Hedemann Sørensen, Nikolaus Plesnila, Leif Østergaard, Nina Kerting Iversen
BACKGROUND: The high mortality and morbidity after subarachnoid hemorrhage (SAH) is partly due to delayed cerebral ischemia, which is traditionally ascribed to development of angiographic vasospasms. This relation has been challenged, and capillary flow disturbances are proposed as another mechanism contributing to brain damage after SAH. OBJECTIVE: To investigate capillary flow changes four days following experimental SAH. METHODS: SAH was induced by endovascular perforation of circle of Willis...
November 15, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30422359/impaired-microvascular-reactivity-in-gestational-diabetes-is-associated-with-altered-glycemic-parameters
#6
Aisyah Rahman, Seetha Munisamy, Nor Aliza Ghaffar, Nik Zaki Mahmood, Aida Hg Rasool
OBJECTIVES: To assess microvascular reactivity and glycemic parameters in gestational diabetes mellitus (GDM) compared to age and gestational age (GA) matched controls. METHODS: This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using laser Doppler fluximetry and post-occlusive skin reactive hyperemia (PORH). Microvascular parameters; PORHmax , PORHpeak , and time to peak perfusion (Tp) were recorded after release of three minutes' upper arm occlusion...
November 13, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30422357/urinary-albumin-excretion-in-rheumatoid-arthritis-is-not-associated-with-markers-of-vasculopathy-in-distal-microvascular-beds
#7
Panagiota Anyfanti, Areti Triantafyllou, Eugenia Gkaliagkousi, Xenophon Zabulis, Panagiotis Dolgyras, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
OBJECTIVE: Increased urinary albumin excretion (UAE) is a marker of generalized vascular damage in high cardiovascular risk patients. However, it remains unknown whether it corresponds to a state of diffuse vasculopathy in high-risk patients with rheumatoid arthritis (RA). METHODS: UAE was estimated in 24-hour urine samples in RA and non-RA individuals. Retinal arteriolar and venular diameters were calculated from retinal images with computerized software. Subendocardial viability ratio was estimated as an index of microvascular coronary perfusion with applanation tonometry...
November 13, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30383330/in-vitro-model-reveals-a-role-for-mechanical-stretch-in-the-remodeling-response-of-lymphatic-muscle-cells
#8
Joshua S T Hooks, Cristina C Clement, Hoang-Dung Nguyen, Laura Santambrogio, J Brandon Dixon
OBJECTIVE: Using primary LMCs in vitro, we sought to characterize the impact of LMC remodeling on their functional and molecular response to mechanical loading and culture conditions. METHODS: Primary "wounded leg" LMCs were derived from the hindlimb of three sheep who underwent lymphatic injury 6 weeks prior, while "control leg" LMCs were derived from the contralateral, unwounded, limb. Function of the LMCs was characterized in response to media of variable levels of serum (10% vs 0...
November 1, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30383326/the-role-of-%C3%AE-2-adrenergic-receptors-in-hypertensive-pre-eclampsia-a-hypothesis
#9
Dina Maaliki, Khodr Issa, Tuqa Al Shehabi, Ahmed El-Yazbi, Ali H Eid
Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including thrombocytopenia, liver impairment, pulmonary edema, and cerebral disturbances. However, vascular dysfunction remains the core pathological driver of preeclampsia. Defective placental implantation followed by dysfunctional placental spiral artery development promote a hypoxic environment. Massive endothelial dysfunction characterized by reduced vasodilation, augmented vasoconstriction, and increased vascular permeability and inflammation ensues...
November 1, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30365187/von-willebrand-factor-contribution-to-pathophysiology-outside-of-von-willebrand-disease
#10
Anahita Mojiri, Parnian Alavi, Nadia Jahroudi
Von Willebrand factor is a procoagulant protein that plays a central role in initiation of platelets aggregate formation and thrombosis. While von Willebrand disease has long been known to result from qualitative and quantitative deficiencies of VWF, it is more recently that contribution of elevated levels of VWF to various pathological conditions including thrombosis, inflammation, angiogenesis, and cancer metastasis have been appreciated. Here we discuss contribution of elevated levels of VWF to various thrombotic and non-thrombotic pathological conditions...
October 26, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30365186/subclinical-myocardial-dysfunction-in-coronary-slow-flow-phenomenon-identification-by-speckle-tracking-echocardiography
#11
Yumeng Xing, Jing Shi, Yan Yan, Yu Liu, Yongle Chen, Dehong Kong, Xianhong Shu, Cuizhen Pan
OBJECTIVE: This study aimed to determine whether speckle tracking echocardiography (STE) could help detect subclinical myocardial dysfunction in patients with coronary slow flow phenomenon (CSFP). METHODS: Sixty patients with CSFP confirmed by coronary angiography (CAG) and 51 controls with normal coronary flow were prospectively enrolled. Coronary angiographic data and conventional and speckle tracking echocardiographic parameters of the left ventricle (LV) and right ventricle (RV) were obtained for every subject...
October 26, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30338879/molecular-determinants-of-microvascular-dysfunction-in-hypertensive-pregnancy-and-preeclampsia
#12
Wentao Yu, Wei Gao, Dan Rong, Zhixian Wu, Raouf A Khalil
Preeclampsia is a pregnancy-related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are unclear. Defective placentation and apoptosis of invasive cytotrophoblasts cause inadequate remodeling of spiral arteries, placental ischemia and reduced uterine perfusion pressure (RUPP). RUPP causes imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic vascular endothelial growth factor and placental growth factor, and stimulates the release of proinflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin AT1 receptor agonistic autoantibodies...
October 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30281888/sphingosine-1-phosphate-protects-against-brain-microvascular-endothelial-junctional-protein-disorganization-and-barrier-dysfunction-caused-by-alcohol
#13
Natascha G Alves, Sarah Y Yuan, Jerome W Breslin
OBJECTIVE: S1P has known endothelial barrier-protective properties, but whether this extends to the BBB is unclear. We hypothesized that alcohol-induced disruption of brain microvascular endothelial barrier function and junctional protein organization can be ameliorated by S1P treatment. METHODS: Cultured primary HBMEC monolayers were used to characterize endothelial-specific mechanisms of BBB regulation. TER and apparent permeability coefficients for albumin, dextran-4 kDa, and sodium fluorescein were used as indices of barrier function...
October 3, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30276964/microvascular-circulatory-dysregulation-driven-in-part-by-cystathionine-gamma-lyase-a-new-paradigm-for-cardiovascular-compromise-in-the-preterm-newborn
#14
Rebecca M Dyson, Hannah K Palliser, Nicole Wilding, Megan A Kelly, Grazyna Chwatko, Rafal Glowacki, Mary J Berry, Xin Ni, Ian M R Wright
OBJECTIVE: H2 S may explain the dysregulation of microvascular tone associated with poor outcome following preterm birth. In adult vasculature, H2 S is predominantly produced by CSE. We hypothesized that vascular CSE activity contributes to microvascular tone regulation during circulatory transition. METHODS: Preterm (GA62) and full-term (GA69) guinea pig fetuses and neonates were studied. Microvascular blood flow was assessed by laser Doppler flowmetry. Thiosulfate, primary urinary metabolite of H2 S, was determined by high-performance liquid chromatography...
October 1, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30192430/relationship-between-the-endothelial-glycocalyx-and-the-extent-of-coronary-atherosclerosis
#15
Xian-Jun Xue, Yan Jiang, Liang Chen, Shao-Liang Chen
OBJECTIVE: To investigate the correlation between the EG and the severity of coronary atherosclerosis. METHODS: A total of193 subjects were divided into two groups. A SDF video microscope with a glycocalyx thickness measurement system was used to visualize the sublingual microcirculation. The levels of HA in the peripheral circulation and coronary circulation were determined via enzyme-linked immunosorbent assay. The number of coronary artery lesions and the Gensini score were used to evaluate the severity of the coronary atherosclerosis...
November 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30192423/a-new-complimentary-web-based-tool-for-manual-analysis-of-microcirculation-videos-validation-of-the-capillary-mapper-against-the-current-gold-standard-ava-3-2
#16
Michael Hessler, Philip-Helge Arnemann, Frédéric Zamit, Laura Seidel, Tim-Gerald Kampmeier, Ulrich Kathöfer, Andrea Morelli, Can Ince, Sebastian W Rehberg, Christian Ertmer
OBJECTIVE: The aim of the current study was to compare a newly developed web-based freely accessible software program for manual analysis of the microcirculation, the Capillary Mapper (CM), with AVA 3.2 software (AVA; MicroVision Medical B.V., Amsterdam, The Netherlands), which is the current gold standard for analysis of microcirculation videos. METHODS: A web-based software program was developed, which enables manual analysis of videos of the microcirculation to be carried out according to recommendations of the 2018 consensus conference...
November 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30178892/the-protective-effect-of-betulinic-acid-on-microvascular-responsivity-and-protein-expression-in-alzheimer-disease-induced-by-cerebral-micro-injection-of-beta-amyloid-and-streptozotocin
#17
Alireza Sarkaki, Yaghoob Farbood, Mohammad Badavi, Ata Ghadiri, Mohammad Ghasemi Dehcheshmeh, Esrafil Mansouri, Seyedeh Parisa Navabi
OBJECTIVE: Alzheimer's disease (AD) is mainly caused by accumulation of β-amyloid (Aβ) in vessels or parenchyma of the brain. Accordingly, natural compounds such as betulinic acid (BA) might improve the AD signs by increase in blood flow and through reduction in amyloid plaques. METHODS: Intra-hippocampal injection of BA (0.2 and 0.4 μmol/L /10 μL DMSO /rat) was done at intervals of 180 and 10 min before co-microinjection of 0.1 μmol/L Aβ dissolved in PBS (5 μL/rat, hippocampi) and 1...
November 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30178505/induction-of-microvascular-network-growth-in-the-mouse-mesentery
#18
Ariana D Suarez-Martinez, Shayn M Peirce, Brant E Isakson, Matthew Nice, Jack Wang, Karen M Lounsbury, Joshua P Scallan, Walter L Murfee
OBJECTIVE: Motivated by observations of mesenteries harvested from mice treated with tamoxifen dissolved in oil for inducible gene mutation studies, the objective of this study was to demonstrate that microvascular growth can be induced in the avascular mouse mesentery tissue. METHODS: C57BL/6 mice were administered an IP injection for five consecutive days of: saline, sunflower oil, tamoxifen dissolved in sunflower oil, corn oil, or peanut oil. RESULTS: Twenty-one days post-injection, zero tissues from saline group contained branching microvascular networks...
November 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30159948/variation-of-endothelium-related-hemostatic-factors-during-sepsis
#19
Ioannis Vasileiadis, Marianna Politou, Stavros Dimopoulos, Nikoletta Rovina, Magdalini Kyriakopoulou, Anna Kyriakoudi, Elli-Sophia Tripodaki, Theodora Koutsouri, Evangelos Terpos, Nikolaos Koulouris, Antonia Koutsoukou
OBJECTIVE: The thrombomodulin/protein C and VWF/ADAMTS-13 pathways are disturbed in sepsis and have been implicated in the coagulation disorders that characterize the septic syndrome. We aimed to assess the variation of these endothelial parameters during sepsis and their putative association with outcome, in critically ill, septic patients. METHODS: We monitored 34 septic patients, 23 of whom improved (group A) while 11 deteriorated (group B). We assessed ADAMTS-13 levels, VWF activity, soluble thrombomodulin, and protein C activity upon admission to the ICU (time point 0) and at the time of a change in the clinical condition (remission or deterioration, time point 1)...
November 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30120860/lncrna-fendrr-mediates-vegfa-to-promote-the-apoptosis-of-brain-microvascular-endothelial-cells-via-regulating-mir-126-in-mice-with-hypertensive-intracerebral-hemorrhage
#20
Baizhuo Dong, Bin Zhou, Zhigang Sun, Shengming Huang, Liang Han, Honghua Nie, Guohui Chen, Shibing Liu, Yanna Zhang, Ning Bao, Xiaolong Yang, Hongwei Feng
BACKGROUND: LncRNA-FENDRR is a kind of endothelial genes critical for vascular development. Moreover, miR-126 and vascular endothelial growth factor A (VEGFA) are also involved in the physiological process of vascular endothelial cells. This study aimed to the underlying mechanism of FENDRR involving miR-126 and VEGFA in hypertensive intracerebral hemorrhage (HICH). METHODS: C57BL/6 mice were chosen to establish HICH model. The expression of FENDRR, miR-126, and VEGFA at mRNA level was determined by qRT-PCR...
November 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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