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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://www.readbyqxmd.com/read/30281888/sphingosine-1-phosphate-protects-against-brain-microvascular-endothelial-junctional-protein-disorganization-and-barrier-dysfunction-caused-by-alcohol
#1
Natascha G Alves, Sarah Y Yuan, Jerome W Breslin
OBJECTIVE: S1P has known endothelial barrier-protective properties, but whether this extends to the BBB is unclear. We hypothesized that alcohol-induced disruption of brain microvascular endothelial barrier function and junctional protein organization can be ameliorated by S1P treatment. METHODS: Cultured primary HBMEC monolayers were used to characterize endothelial-specific mechanisms of BBB regulation. TER and apparent permeability coefficients for albumin, dextran-4 kDa, and sodium fluorescein were used as indices of barrier function...
October 3, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30276964/microvascular-circulatory-dysregulation-driven-in-part-by-cystathionine-gamma-lyase-a-new-paradigm-for-cardiovascular-compromise-in-the-preterm-newborn
#2
Rebecca M Dyson, Hannah K Palliser, Nicole Wilding, Megan A Kelly, Grazyna Chwatko, Rafal Glowacki, Mary J Berry, Xin Ni, Ian M R Wright
OBJECTIVE: Hydrogen sulphide (H2 S) may explain the dysregulation of microvascular tone associated with poor outcome following preterm birth. In adult vasculature, H2 S is predominantly produced by cystathionine-γ-lyase (CSE). We hypothesised that vascular CSE activity contributes to microvascular tone regulation during circulatory transition. METHOD: Preterm (GA62) and full-term (GA69) guinea pig fetuses and neonates were studied. Microvascular blood flow was assessed by laser Doppler flowmetry...
October 1, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30192430/relationship-between-the-endothelial-glycocalyx-and-the-extent-of-coronary-atherosclerosis
#3
Xian-Jun Xue, Yan Jiang, Liang Chen, Shao-Liang Chen
OBJECTIVE: To investigate the correlation between the endothelial glycocalyx (EG) and the severity of coronary atherosclerosis. METHODS: 193 subjects were divided into two groups. A side-stream dark field video microscope with a glycocalyx thickness measurement system was used to visualize the sublingual microcirculation. The levels of hyaluronan acid (HA) in the peripheral circulation and coronary circulation were determined via enzyme linked immunosorbent assay...
September 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30192423/a-new-complimentary-web-based-tool-for-manual-analysis-of-microcirculation-videos-validation-of-the-capillary-mapper-against-the-current-gold-standard-ava-3-2
#4
Michael Hessler, Philip-Helge Arnemann, Frédéric Zamit, Laura Seidel, Tim-Gerald Kampmeier, Ulrich Kathöfer, Andrea Morelli, Can Ince, Sebastian Willy Rehberg, Christian Ertmer
OBJECTIVE: The aim of the current study was to compare a newly developed web-based freely accessible software program for manual analysis of the microcirculation, the Capillary Mapper (CM), with AVA3.2 software (AVA; MicroVision Medical B.V., Amsterdam, the Netherlands), which is the current gold standard for analysis of microcirculation videos. METHODS: A web-based software program was developed, which enables manual analysis of videos of the microcirculation to be carried out according to recommendations of the 2018 consensus conference...
September 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30178892/the-protective-effect-of-betulinic-acid-on-microvascular-responsivity-and-protein-expression-in-alzheimer-disease-induced-by-cerebral-micro-injection-of-beta-amyloid-and-streptozotocin
#5
Alireza Sarkaki, Yaghoob Farbood, Mohammad Badavi, Ata Ghadiri, Mohammad Ghasemi Dehcheshmeh, Esrafil Mansouri, Seyedeh Parisa Navabi
OBJECTIVE: Alzheimer's disease (AD) is mainly caused by accumulation of β-amyloid (Aβ) in vessels or parenchyma of the brain. Accordingly, natural compounds such as betulinic acid (BA) might improve the AD signs by increase of blood flow and through reduction of amyloid plaques. METHODS: Intra-hippocampal injection of BA (0.2 and 0.4μM /10μl DMSO /rat) was done at intervals of 180 and 10 min before co-microinjection of 0.1μM Aβ dissolved in PBS (5μl/rat, hippocampi) and 1...
September 4, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30178505/induction-of-microvascular-network-growth-in-the-mouse-mesentery
#6
Ariana D Suarez-Martinez, Shayn M Peirce, Brant E Isakson, Matthew Nice, Jack Wang, Karen M Lounsbury, Joshua P Scallan, Walter L Murfee
OBJECTIVE: Motivated by observations of mesenteries harvested from mice treated with tamoxifen dissolved in oil for inducible gene mutation studies, the objective of this study was to demonstrate that microvascular growth can be induced in the avascular mouse mesentery tissue. METHODS: C57BL/6 mice were administered an IP injection for 5 consecutive days of: saline, sunflower oil, tamoxifen dissolved in sunflower oil, corn oil, or peanut oil. RESULTS: Twenty-one days post-injection, zero tissues from saline group contained branching microvascular network...
September 4, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30178465/modified-redox-signalling-in-vasculature-after-chronic-infusion-of-the-insulin-receptor-antagonist-s961
#7
Kristen J Bubb, Rebecca H Ritchie, Gemma A Figtree
BACKGROUND: Type 2 diabetes and associated vascular complications cause substantial morbidity and mortality. It is important to investigate mechanisms and test therapies in relevant physiological models, yet few animal models adequately recapitulate all aspects of the human condition. OBJECTIVE: We sought to determine the potential of using an insulin receptor antagonist, S961, in mice for investigating vascular pathophysiology. METHODS: S961 was infused into mice for four weeks...
September 4, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30159948/variation-of-endothelium-related-hemostatic-factors-during-sepsis
#8
Ioannis Vasileiadis, Marianna Politou, Stavros Dimopoulos, Nikoletta Rovina, Magdalini Kyriakopoulou, Anna Kyriakoudi, Elli-Sophia Tripodaki, Theodora Koutsouri, Evangelos Terpos, Nikolaos Koulouris, Antonia Koutsoukou
OBJECTIVE: The thrombomodulin/protein C and VWF/ADAMTS-13 pathways are disturbed in sepsis, and have been implicated in the coagulation disorders that characterize the septic syndrome. We aimed to assess the variation of these endothelial parameters during sepsis and their putative association with outcome, in critically ill, septic patients. METHODS: We monitored 34 septic patients, 23 of whom improved (group A) while 11 deteriorated (group B). We assessed ADAMTS-13 levels, VWF activity, soluble thrombomodulin and protein C activity upon admission to the ICU (time point 0) and at the time of a change in the clinical condition (remission or deterioration, time point 1)...
August 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30120860/lncrna-fendrr-mediates-vegfa-to-promote-the-apoptosis-of-brain-microvascular-endothelial-cells-via-regulating-mir-126-in-mice-with-hypertensive-intracerebral-hemorrhage
#9
Baizhuo Dong, Zhigang Sun, Bin Zhou, Shengming Huang, Liang Han, Honghua Nie, Guohui Chen, Shibing Liu, Yanna Zhang, Ning Bao, Xiaolong Yang, Hongwei Feng
BACKGROUND: LncRNA-FENDRR is a kind of endothelial genes critical for vascular development. Moreover, miR-126 and vascular endothelial growth factor A (VEGFA) are also involved in the physiological process of vascular endothelial cells. This study aimed to the underlying mechanism of FENDRR involving miR-126 and VEGFA in hypertensive intracerebral hemorrhage (HICH). METHODS: C57BL/6 mice were chosen to establish HICH model. The expression of FENDRR, miR-126 and VEGFA at mRNA level were determined by qRT-PCR...
August 18, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30120855/mast-cells-and-primary-systemic-vasculitides
#10
REVIEW
Domenico Ribatti, Roberto Tamma, Simona Ruggieri, Tiziana Annese, Andrea Marzullo, Enrico Crivellato
Vasculitides are characterized by inflammation and necrosis of blood vessels leading to vessel occlusion and ischemic damages of tissues. Among the inflammatory cells involved in vasculitides, neutrophils, T cells, and macrophages have been identified as the predominant cell type. This review article is focused on the role of mast cells in these chronic inflammatory processes. Mast cells are characterized by their complex plasticity. Increasing evidences document that mast cells exert both pro- and anti-inflammatory functions depending on the cell types and the microenvironment they reside in...
August 18, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30120845/skeletal-muscle-interstitial-o-2-pressures-bridging-the-gap-between-the-capillary-and-myocyte
#11
Daniel M Hirai, Trenton D Colburn, Jesse C Craig, Kazuki Hotta, Yutaka Kano, Timothy I Musch, David C Poole
The oxygen transport pathway from air to mitochondria involves a series of transfer steps within closely integrated systems (pulmonary, cardiovascular and tissue metabolic). Small and finite O2 stores in most mammalian species require exquisitely controlled changes in O2 flux rates to support elevated ATP turnover. This is especially true for the contracting skeletal muscle where O2 requirements may increase two orders of magnitude above rest. This brief review focuses on the mechanistic bases for increased microvascular blood-myocyte O2 flux (V̇O2 ) from rest-to-contractions...
August 18, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30030876/the-pulmonary-microvasculature-entraps-induced-vascular-progenitor-cells-ivpcs-systemically-delivered-after-cardiac-ischemia-reperfusion-injury-indication-for-preservation-of-heart-function-via-paracrine-effects-beyond-engraftment
#12
Melanie Ziegler, Katharina Haigh, Thao Nguyen, Xiaowei Wang, Bock Lim, May Lin Yap, Eleanor M Eddy, Jody J Haigh, Karlheinz Peter
OBJECTIVE: Stem cell-based regenerative therapies have been intensively studied with the aim to define an ideal cell type for the treatment of myocardial infarction. We tested systemically delivered, platelet-targeted induced vascular progenitor cells (iVPCs) to study their potential to salvage damaged myocardium after ischemia-reperfusion injury. METHODS: Using a mouse model of ischemia-reperfusion injury, we tested the potential of platelet-targeted iVPCs (1 × 106 targ-iVPCs) compared to non-targ-iVPCs and a saline control...
July 21, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30040171/the-contribution-of-carbon-monoxide-to-vascular-tonus
#13
Günnur Koçer, Seher Nasircilar Ülker, Ümit Kemal Şentürk
OBJECTIVE: The aim of this descriptive study was to examine the contribution of CO in the maintenance of vascular tonus in different organs and different vessel segments; the underlying mechanism of CO-induced vasodilation was investigated. METHODS: Sixty Wistar albino rats, aged 6-8 months, were used in this study. Response to CO by isolated arteries from the thoracic and abdominal aorta and mesenteric, renal, gastrocnemius, and gracilis muscles as well as heart, lung, and brain vascular beds was endogenously and exogenously studied using organ baths or myograph...
October 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30030943/arteriolar-and-capillary-responses-to-co-2-and-h-in-hamster-skeletal-muscle-microvasculature-implications-for-active-hyperemia
#14
Mackenzie E Charter, Iain R Lamb, Coral L Murrant
OBJECTIVE: We hypothesized that CO2 and H+ stimulate capillaries and arterioles to produce local and conducted vasodilations required to coordinate the distribution of blood flow to contracting skeletal muscle fibers. METHODS: CO2 and H+ independently and in combination were applied to 2A arterioles (first branch order from the 1A feed arteriole) and capillaries of the in situ, blood-perfused hamster cremaster muscle. The resulting local and conducted vasodilations were measured...
October 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30027659/reversible-impairment-of-coronary-flow-reserve-in-acute-myocarditis
#15
Joerg Kellermair, Daniel Kiblboeck, Hermann Blessberger, Juergen Kammler, Christian Reiter, Clemens Steinwender
OBJECTIVE: Acute myocarditis is accompanied by an impaired coronary microcirculation. These microcirculatory disturbances are not well defined, and data are derived from complex invasive measurements. Therefore, this study aimed to evaluate the inflammation-induced microcirculatory dysfunction including its reversibility and association with markers of inflammation severity (extent of LGE on CMR imaging and laboratory markers of myocardial necrosis) using the noninvasive technique of echocardiographic CFR measurement...
October 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30025187/insulin-resistance-disrupts-cell-integrity-mitochondrial-function-and-inflammatory-signaling-in-lymphatic-endothelium
#16
Yang Lee, Sanjukta Chakraborty, Cynthia J Meininger, Mariappan Muthuchamy
OBJECTIVE: Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects the metabolic function of cells and consequently impairs tissue function. We hypothesized that insulin resistance in LECs decreases eNOS activity, disrupts barrier integrity increases permeability, and activates mitochondrial dysfunction and pro-inflammatory signaling pathways...
October 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29999581/ovarian-hormones-modulate-endothelin-1-receptor-responses-in-young-women
#17
Kelly N Sebzda, Andrew V Kuczmarski, Ryan T Pohlig, Shannon L Lennon, David G Edwards, Megan M Wenner
OBJECTIVE: We recently demonstrated ETBR mediate vasodilation in young but not postmenopausal women; it is unclear if this is related to age or a decline in ovarian hormones. The purpose of this study was to test the hypothesis that ETBR responses are modulated by ovarian hormones. METHODS: We measured cutaneous vasodilatory responses in 12 young women (22 ± 1 years, 23 ± 1 kg/m2 ) during the ML (days 20-25) and EF (days 2-5) phases of the menstrual cycle...
October 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29923664/differential-arterial-and-venous-endothelial-redox-responses-to-oxidative-stress
#18
Bandana Shrestha, Priya K Prasai, Amir M Kaskas, Ankur Khanna, Vijay Letchuman, Sunjay Letchuman, Jonathan Steven Alexander, A Wayne Orr, Matthew D Woolard, Christopher B Pattillo
OBJECTIVE: Oxidative stress is a central event linked with endothelial dysfunction and inflammation in several vascular pathologies, marked by over-production of ROS and concomitant decreases in antioxidants, for example GSH. Here, we distinguish endothelial oxidative stress regulation and associated functional disparities in the two main vascular conduits, (arteries and veins) following decreases in GSH. METHODS: MAECs and VCECs were used as models of arterial and venular endothelium, respectively, and BSO (0-100 μmol/L) was used to indirectly increase cellular oxidative stress...
October 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29964354/abstracts-of-the-68-th-annual-meeting-in-university-of-nottingham
#19
Melissa Gammons
Placental hypervascularization observed in gestational diabetes mellitus (GDM) may be related to functional availability of vascular endothelial growth factor (VEGF) and its receptors. We aimed to test whether changes in phosphorylation of tyrosine 951 or tyrosine 1175 (pY951 or pY1175) of the vascular endothelial growth factor receptor 2 (VEGFR2) are associated with the proangiogenic state observed in placentas from GDM This article is protected by copyright. All rights reserved.
July 2, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29846993/aging-attenuates-adenosine-triphosphate-induced-but-not-muscarinic-and-nicotinic-cutaneous-vasodilation-in-men
#20
Naoto Fujii, Takeshi Nishiyasu, Ronald J Sigal, Pierre Boulay, Gregory W McGarr, Glen P Kenny
OBJECTIVE: We evaluated the hypothesis that aging attenuates muscarinic, nicotinic, and ATP-related cutaneous vasodilation. METHODS: In 11 young (24 ± 4 years) and 11 older males (61 ± 8 years), CVC was assessed at 3 forearm skin sites that were infused with either: (i) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 mmol/L), (ii) nicotine (nicotinic receptor agonist, 5 doses: 1.2, 3.6, 11, 33, 100 mmol/L), or (iii) ATP (purinergic receptor agonist, 5 doses: 0...
July 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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