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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://www.readbyqxmd.com/read/28801994/influence-of-feeding-hematocrit-and-perfusion-pressure-on-hematocrit-reduction-f%C3%A3-hraeus-effect-in-an-artificial-microvascular-network
#1
Walter H Reinhart, Nathaniel Z Piety, Sergey S Shevkoplyas
OBJECTIVE: Hematocrit in narrow vessels is reduced due to concentration of fast flowing red blood cells (RBC) in the center, and of slower flowing plasma along the wall of the vessel, which in combination with plasma skimming at bifurcations leads to the striking heterogeneity of local hematocrit in branching capillary networks known as the network Fåhraeus effect. We analyzed the influence of feeding hematocrit and perfusion pressure on the Fåhraeus effect in an artificial microvascular network (AMVN)...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28801985/between-day-reliability-of-local-thermal-hyperaemia-in-the-forearm-and-index-finger-using-single-point-laser-doppler-flowmetry
#2
Gregory W McGarr, Gary J Hodges, Stephen S Cheung
OBJECTIVE: To assess between-day reliability for local thermal hyperaemia (LTH) in glabrous and non-glabrous index finger skin and non-glabrous forearm skin, with single point laser-Doppler flowmetry. METHODS: Part-1: In healthy, habitually active males (n=10), LTH was examined twice (~7-10 d apart) for both skin types on the index finger. Part-2: Identical testing was performed on the volar forearm. Local heating (33-42°C at 1°C·20 s(-1) +20 min at 44°C) was performed at all skin sites and baseline, initial peak, and plateau phases were identified...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28791758/agent-based-computational-model-of-retinal-angiogenesis-simulates-microvascular-network-morphology-as-a-function-of-pericyte-coverage
#3
Joseph Walpole, Feilim Mac Gabhann, Shayn M Peirce, John C Chappell
OBJECTIVE: Define a role for perivascular cells during developmental retinal angiogenesis in the context of endothelial cell Notch1-DLL4 signaling at the multicellular network level. METHODS: The retinal vasculature is highly sensitive to growth factor mediated intercellular signaling. Although endothelial cell signaling has been explored in detail, it remains unclear how pericytes function to modulate these signals that lead to a diverse set of vascular network patterns in health and disease...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28791754/endothelial-precursor-cells-stimulate-pericyte-like-coverage-of-bone-marrow-derived-mesenchymal-stem-cells-through-pdgf-bb-induction-which-is-enhanced-by-substance-p
#4
Mingzi Zhang, Woosung Ahn, Sumin Kim, Hyun Sook Hong, Chengshi Quan, Youngsook Son
OBJECTIVE: The aim of this study was to evaluate the angiogenicity of a combination of bone marrow-derived endothelial precursor cells (BM-EPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) in vitro in the presence of substance P (SP), and its working mechanism. METHODS: BM-MSCs and BM-EPCs were co-cultured with or without SP. ELISA and RT-PCR were performed to detect angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-BB)...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28787770/dosing-of-indocyanine-green-for-intraoperative-laser-fluorescence-angiography-in-kidney-transplantation
#5
Ulrich Rother, Andreas L H Gerken, Ioannis Karampinis, Madeline Klumpp, Susanne Regus, Alexander Meyer, Hendrik Apel, Bernhard K Krämer, Karl Hilgers, Werner Lang, Kai Nowak
OBJECTIVE: Sufficient blood supply is a crucial factor determining postoperative allograft function in kidney transplantation. Therefore, besides the surgeon's individual impression a method for evaluating the quality of the organ's microperfusion is required. Laser fluorescence angiography with indocyanine-green (ICG) is an emerging tool for this purpose. However, no reproducible quantification of ICG fluorescence has been performed in transplantation so far. METHODS: This retrospective two-center study was designed to evaluate the dosing of ICG for intraoperative laser fluorescence angiography in kidney transplantation...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28665547/effects-of-different-intensity-laser-acupuncture-at-two-adjacent-same-meridian-acupoints-on-nitric-oxide-and-soluble-guanylate-cyclase-releases-in-human
#6
Wan-Ling Jiang, Hua-Jiang Wei, Zhou-Yi Guo, Yi-Rong Ni, Hong-Qin Yang, Shu-Sen Xie
OBJECTIVES: The aim of this study was to detect the influences of laser acupuncture (LA) at non-acupoint and two adjacent acupoints of pericardium meridian on the releases of nitric oxide (NO) and soluble guanylate cyclase (sGC) in 20 healthy subjects. METHODS: Different intensities (12 mW, 24 mW, 48 mW) infrared laser were used for irradiating Jianshi (PC5), Ximen (PC4) acupoints and non-acupoint for 20 min, 40 min, respectively. Semi-circular tubes were taped to the skin surface and filled with NO-scavenging compound for 20 min to capture NO and sGC which were measured using spectrophotometry in a blinded fashion...
June 30, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28632939/acute-skin-trauma-induces-hyperemia-but-superficial-papillary-nutritive-perfusion-remains-unchanged
#7
Liv Kristin Sundheim, Ane Halse Sporastøyl, Torjus Wester, Göran Salerud, Knut Kvernebo
OBJECTIVES: Superficial skin papillary capillaries with blood supply from a superficial vascular plexus and regulated by local metabolic needs, supply oxygen and nutrient for epithelial cell proliferation. A deep vascular plexus regulated by autonomous nerves serves body thermoregulation. In healthy volunteers we assessed circulatory effects of a standardised skin trauma by computer assisted video m microscopy (CAVM), diffuse reflectance spectroscopy (DRS), and laser Doppler perfusion measurements (LDPM) to assess the measuring depth of the three techniques and to describe the acute trauma effects on nutritive and thermoregulatory perfusion...
June 20, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28627137/effect-of-sympathetic-nerve-blockade-on-low-frequency-oscillations-of-forearm-and-leg-skin-blood-flow-in-healthy-humans
#8
Gary J Hodges, Matthew M Mallette, Zachary T Martin, Andrew T Del Pozzi
Examine the effect of inhibiting sympathetic function on cutaneous vasomotion in the forearm and leg METHODS: Intradermal microdialysis fibres were placed in the forearm and leg, one as an untreated control (lactated Ringer's) the other perfused with bretylium tosylate to block sympathetic nerves. Skin blood flow was monitored using laser-Doppler flowmetry. Baseline was collected for 10 min before local skin temperature was increased to 42°C. Spectral analysis was performed using a Morlet wavelet RESULTS: Bretylium tosylate increased skin blood flow during baseline in the forearm (d=1...
June 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28627086/the-hypertension-of-hemophilia-is-associated-with-vascular-remodeling-in-the-joint
#9
Richard Fw Barnes, Thomas J Cramer, Tudor H Hughes, Annette von Drygalski
OBJECTIVE: Hemophilic arthropathy is associated with pronounced vascular joint remodeling. Also, compared to the general population, PWH have a higher prevalence of hypertension not explained by usual risk factors. Since vascular remodeling in various vascular beds is a hallmark of hypertension, we hypothesized that vascular joint remodeling is associated with elevated blood pressures and hypertension. METHODS: Elbows, knees and ankles of 28 adult PWH were evaluated for vascular abnormalities with MSKUS/PD, as well as for radiographic and clinical status and pain...
June 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28613418/differences-in-optic-nerve-head-microcirculation-between-evening-and-morning-in-patients-with-coronary-artery-disease
#10
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori
PURPOSE: To determine whether differences or variation of blood flow in the optic nerve head (ONH) are independent risk factors for coronary artery disease (CAD). METHODS: We studied 144 consecutive patients whose ocular blood flow in the ONH was measured in the evening and morning by laser speckle flowgraphy (LSFG). We analysed the mean blur rate (MBR) throughout the ONH (MBR-A) and in the tissue (MBR-T) and vessels (MBR-V) in the ONH. We also evaluated the MBR-T, -V and -A values obtained in the evening and morning and the variation (Δ) between evening and morning values in each group...
June 14, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28597598/rosa-rugosa-flavonoids-alleviate-myocardial-ischemia-reperfusion-injury-in-mice-by-suppressing-jnk-and-p38-mapk
#11
Xuehui Zhang, Yuhui Wang, Wanli Shen, Shangzhi Ma, Wen Chen, Rong Qi
OBJECTIVE: Although Rosa rugosa has been applied for preventing coronary artery disease, the pharmacological mechanism is little explored. In this study, the effects and mechanisms of Rosa rugosa flavonoids (RRF) on myocardial ischemia reperfusion injury (MIRI) were investigated. METHODS: Mice were pretreated by intragastric administration of 600 mg/kg RRF for 7 days. Then MIRI was induced by 45 min coronary artery ligation and 3 h reperfusion. Myocardial infarct size (MIS) and histopathology, activities of myocardial enzymes and effects of RRF on inflammation and apoptosis were evaluated...
June 9, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28585358/muscle-microcirculation-alterations-and-relation-to-dipping-status-in-newly-diagnosed-untreated-patients-with-arterial-hypertension-a-pilot-study
#12
Georgios Tzanis, Stavros Dimopoulos, Chris Manetos, Eleni Koroboki, Efstathios Manios, Ioannis Vasileiadis, Nikolaos Zakopoulos, Serafim Nanas
OBJECTIVE: The importance of abnormalities observed in the microcirculation of patients with arterial hypertension (AH) is being increasingly recognized. The authors aimed to evaluate skeletal muscle microcirculation in untreated, newly diagnosed hypertensive patients with Near Infrared Spectroscopy (NIRS), a non-invasive method that evaluates microcirculation. METHODS: We evaluated 34 subjects, 17 patients with AH (13 males, 49±13y, BMI: 26±2 kg/m(2) ) and 17 healthy controls (12 males, 49±15y, BMI: 25±3 kg/m(2) )...
June 5, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28510992/lymph-node-effective-vascular-permeability-and-chemotherapy-uptake
#13
Eelco F J Meijer, Cedric Blatter, Ivy X Chen, Echoe Bouta, Dennis Jones, Ethel R Pereira, Keehoon Jung, Benjamin J Vakoc, James W Baish, Timothy P Padera
OBJECTIVE: Lymph node metastases are a poor prognostic factor. Additionally, responses of lymph node metastasis to therapy can be different from the primary tumor. Investigating the physiologic lymph node blood vasculature might give insight into the ability of systemic drugs to penetrate the lymph node, and thus into the differential effect of therapy between lymph node metastasis and primary tumors. Here, we measured effective vascular permeability of lymph node blood vessels and attempted to increase chemotherapy penetration by increasing effective vascular permeability...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28480622/roles-of-nadph-oxidase-and-mitochondria-in-flow-induced-vasodilation-of-human-adipose-arterioles-ros-induced-ros-release-in-coronary-artery-disease
#14
Natalya S Zinkevich, Ibra S Fancher, David D Gutterman, Shane A Phillips
OBJECTIVES: H2 O2 contributes to FID of human arterioles. This study is designed to examine the roles of mitochondria and NADPH oxidase in modulating the release of ROS and in mediating FID. We tested whether NADPH oxidase contributes to mitochondrial ROS generation in arterioles during CAD. METHODS: Visceral adipose arterioles obtained from patients with or without CAD were cannulated and pressurized for videomicroscopic measurement of arteriolar diameters. Dilator responses and ROS production during flow were determined in the presence and absence of the NADPH oxidase inhibitor gp91ds-tat and the mitochondrial electron transport inhibitor rotenone...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28477419/the-impact-of-endotoxin-on-jejunal-tissue-oxygenation
#15
Werner Pajk, Karl-Heinz Stadlbauer, Axel Kleinsasser, Oskar Kotzinger, Hanno Ulmer, Walter Hasibeder, Hans Knotzer
OBJECTIVE: We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs. METHODS: Jejunal mucosal tissue PO2 was measured employing Clark-type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28370794/short-term-48%C3%A2-hours-intravenous-serelaxin-infusion-has-no-effect-on-myogenic-tone-or-vascular-remodeling-in-rat-mesenteric-arteries
#16
Maria Jelinic, Chen Huei Leo, Sarah A Marshall, Sevvandi N Senadheera, Laura J Parry, Marianne Tare
BACKGROUND: Short-term IV sRLX (recombinant human relaxin-2) infusion enhances endothelium-dependent relaxation in mesenteric arteries. This is initially underpinned by increased NO followed by a transition to prostacyclin. The effects of short-term IV sRLX treatment on pressure-induced myogenic tone and vascular remodeling in these arteries are unknown. Therefore, we investigated the effects of sRLX infusion on pressure-induced myogenic tone and passive mechanical wall properties in mesenteric arteries...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28296053/vasoactive-effect-of-fibronectin-derived-epiviosamine-1-and-related-peptides-in-quiescent-and-stress-models
#17
Mary D Frame, Fubao Lin, Anthony M Dewar, Richard A F Clark
OBJECTIVE: Following thermal burn injury, plasma fibronectin degrades within the interstitium; one possible product is EVA-1, PSHISKYILRWRPK found within the FNIII1 . EVA-1 ameliorates thermal burn injury progression, and binds to and enhances PDGF-BB in promoting cell metabolism, growth and survival; shorter related peptides lose these abilities. Here we study the effect of EVA-1 and shorter peptides for their vasoactivity under quiescent and stress conditions. METHODS: Using the hamster cheek pouch intravital microscopy model, five EVA-1 related peptides were applied to small arterioles via micropipette (10(-16) -10(-4) mol L(-1) ) in quiescent tissue and after defined stress: nitric oxide or heat...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28261893/astrocyte-activation-and-capillary-remodeling-in-modified-bilateral-common-carotid-artery-occlusion-mice
#18
Jiangman Song, Di Nan, Qihua He, Lu Yang, Huailian Guo
OBJECTIVE: The cerebral ischemia leads to brain dysfunction with neuron degeneration and responses from astrocytes and vessels. The aim of this study was to study the changes of astrocyte and microvessel in modified BCCAO mice. METHODS: Adult transgenic Tie2-GFP mice were subjected to modified BCCAO operation and cranial window implantation. CBF and neurological injury were examined after ischemia. Astrocytes and vessels were investigated by two-photon laser-scanning microscope and confocal laser-scanning microscope in vivo...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28236639/pericyte-modulation-by-a-functional-antibody-obtained-by-a-novel-single-cell-selection-strategy
#19
Jesper Just, Simon Lykkemark, Charlotte H Nielsen, Ali R Roshenas, Kim R Drasbek, Steen V Petersen, Toke Bek, Peter Kristensen
OBJECTIVE: Pericytes surround the endothelial cells of the microvasculature where they serve as active participants in crucial vascular functions such as angiogenesis, stability, and permeability. However, pericyte loss or dysfunction has been described in a number of pathologies. Targeting pericytes could therefore prove instrumental in the further development of vascular therapeutics. METHODS: To target the pericyte, a proteomic-based approach using antibody phage display was conducted...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28177171/increased-survivability-of-ischemic-skin-flap-tissue-in-flk-1-mice-by-pellino-1-intervention
#20
Chandra K Rednam, Rickesha L Wilson, Vaithinathan Selvaraju, Muhammad T Rishi, Mahesh Thirunavukkarasu, Vladimir Coca-Soliz, Rajesh Lakshmanan, John A Palesty, David W McFadden, Nilanjana Maulik
OBJECTIVE: Reduced skin flap survival due to ischemia is a serious concern during reconstructive cosmetic surgery. The absence of VEGF and its receptors during ischemia may lead to flap failure. We identified Peli1, a 46-kDa protein, as a proangiogenic molecule and is directly regulated by VEGF. Therefore, we hypothesized that Peli1 acts downstream of Flk-1/VEGFR2 and aids in skin flap survival during ischemia. METHODS: Scratch and matrigel assays were performed to observe cell proliferation, migration, and tube formation in vitro...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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