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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://www.readbyqxmd.com/read/29924435/the-role-of-senescence-telomere-dysfunction-and-shelterin-in-vascular-aging
#1
Yu Liu, Samuel I Bloom, Anthony J Donato
In the United States and other westernized nations, cardiovascular diseases (CVDs) are the leading cause of death in adults over 65 years of age. Large artery stiffness and endothelial dysfunction are increased with age and age-associated arterial dysfunction is an important antecedent of CVDs. One age-associated change that may contribute to vascular dysfunction and CVD risk is an increase in the number of resident senescence cells in the vasculature. Senescent cells display a pro-oxidant, pro-inflammatory phenotype known as the senescence associated secretory phenotype (SASP)...
June 20, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29923664/differential-arterial-and-venous-endothelial-redox-responses-to-oxidative-stress
#2
Bandana Shrestha, Priya K Prasai, Amir M Kaskas, Ankur Khanna, Vijay Letchuman, Sunjay Letchuman, J Steven Alexander, A Wayne Orr, Matthew D Woolard, Christopher B Pattillo
OBJECTIVE: Oxidative stress is a central event linked with endothelial dysfunction and inflammation in several vascular pathologies, marked by over-production of ROS and concomitant decreases in antioxidants e.g. GSH. Here we distinguish endothelial oxidative stress regulation and associated functional disparities in the two main vascular conduits, (arteries and veins) following decreases in GSH. METHODS: MAECs and VCECs were used as models of arterial and venular endothelium, respectively and BSO (0-100μM) was used to indirectly increase cellular oxidative stress...
June 20, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29923276/extracellular-vesicles-and-microvascular-pathology-decoding-the-active-dialogue
#3
Elham Hosseini Beheshti, Georges Emile Raymond Grau
More than seventy years ago Chargaff and West reported the presence of platelet-derived particles in normal plasma. Since then, an enormous number of studies have aimed at characterising the diversity of extracellular vesicles (EV) and understanding their role in biological and pathological processes, both as elements of communication vesicles and as biological transporters. This article is protected by copyright. All rights reserved.
June 20, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908049/imaging-sublingual-microcirculatory-perfusion-in-pediatric-patients-receiving-procedural-sedation-with-propofol-a-pilot-study
#4
M A Riedijk, D M J Milstein
OBJECTIVE: Procedural sedation with propofol is widely used in the pediatric population. A well-known side effect of propofol is a decrease of peripheral vascular resistance resulting in hypotension, but little is known about the effects on the microcirculation in humans. We aimed to evaluate the effects of propofol on the sublingual microcirculatory perfusion by continuous video imaging in pediatric patients undergoing procedural sedation. METHODS: Patients admitted to the Pediatric Intensive Care Unit for procedural sedation were recruited...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908046/sepsis-induced-acute-kidney-injury-a-disease-of-the-microcirculation
#5
Shuai Ma, Roger G Evans, Naoya Iguchi, Marianne Tare, Helena C Parkington, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva
Acute kidney injury (AKI) is a common complication of sepsis and is significantly associated with mortality. Sepsis accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The pathogenesis of septic AKI is complex, but there is emerging evidence that, at least in the first 48 hours, the defects may be functional rather than structural in nature. For example, septic AKI is associated with an absence of histopathological changes, but with microvascular abnormalities and tubular stress...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908041/automated-quantification-of-microvascular-perfusion
#6
P Mason McClatchey, Nicholas A Mignemi, Zhengang Xu, Ian M Williams, Jane E B Reusch, Owen P McGuinness, David H Wasserman
OBJECTIVE: Changes in microvascular perfusion have been reported in many diseases, yet the functional significance of altered perfusion is often difficult to determine. This is partly because commonly used techniques for perfusion measurement often rely on either indirect or by-hand approaches. METHODS: We developed and validated a fully automated software technique to measure microvascular perfusion in videos acquired by fluorescence microscopy in the mouse gastrocnemius...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29885064/a-dynamic-computational-network-model-for-the-role-of-nitric-oxide-and-the-myogenic-response-in-microvascular-flow-regulation
#7
Yien Liu, Donald G Buerk, Kenneth A Barbee, Dov Jaron
OBJECTIVES: The effect of nitric oxide (NO) on smooth muscle cell contractility is crucial in regulating vascular tone, blood flow, and O2 delivery. Quantitative predictions for interactions between the NO production rate and the myogenic response for microcirculatory blood vessels are lacking. METHODS: We developed a computational model of a branching microcirculatory network with four representative classes of resistance vessels to predict the effect of endothelium-derived NO on the microvascular pressure-flow response...
June 8, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29876993/from-pregnancy-to-cardiovascular-disease-lessons-from-relaxin-deficient-animals-to-understanding-relaxin-actions-in-the-vascular-system
#8
Maria Jelinic, Sarah A Marshall, Chen Huei Leo, Laura J Parry, Marianne Tare
Early maternal vascular adaptations to pregnancy are predominantly driven by changes in vascular tone, reactivity and remodelling. Failure of the maternal systemic vasculature to adapt sufficiently can lead to serious complications of pregnancy. The hormone relaxin is widely recognised for its contribution to the essential renal and systemic haemodynamic adaptations in early pregnancy through direct actions on the maternal vasculature. Studies in relaxin gene knockout mice revealed that endogenous relaxin is not only a 'pregnancy hormone' but has pleiotropic actions in various tissues in males and non-pregnant females...
June 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29846993/aging-attenuates-atp-induced-but-not-muscarinic-and-nicotinic-cutaneous-vasodilation-in-men
#9
Naoto Fujii, Takeshi Nishiyasu, Ronald J Sigal, Pierre Boulay, Gregory W McGarr, Glen P Kenny
OBJECTIVE: We evaluated the hypothesis that aging attenuates muscarinic, nicotinic, and ATP- related cutaneous vasodilation. METHODS: In 11 young (24±4 years) and 11 older males (61±8 years), cutaneous vascular conductance (CVC) was assessed at three forearm skin sites that were infused with either: 1) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 mM), 2) nicotine (nicotinic receptor agonist, 5 doses: 1.2, 3.6, 11, 33, 100 mM), or 3) adenosine triphosphate (ATP) (purinergic receptor agonist, 5 doses: 0...
May 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29846990/aging-and-vascular-related-pathologies
#10
Shu Wen Wen, Connie H Y Wong
Our aging population is set to grow considerably in the coming decades. In fact, the number of individuals older than 65 years will double by 2050. This projected increase of people living with extended life expectancy represents an inevitable upsurge in the presentation of age-related pathologies. However, our current understanding of the impact of aging on a number of biological processes is unfortunately inadequate. Cardiovascular, cerebrovascular and neurodegenerative diseases are particularly prevalent in the elderly population...
May 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29770525/establishment-and-characterization-of-an-embryonic-pericyte-cell-line
#11
Huaning Zhao, Jordan Darden, John C Chappell
OBJECTIVE: Pericytes are specialized perivascular cells embedded within the basement membrane. These cells envelope the abluminal surface of endothelial cells and promote microvessel homeostasis. Recent discoveries of unique pericyte functions, particularly in neural tissues, underscore the need for overcoming existing challenges in establishing a functionally validated pericyte cell line. Here, we present methodologies for addressing these challenges as well as an embryonic pericyte cell line for use with in vitro and ex vivo experimental models...
May 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29758591/mineralocorticoid-receptor-antagonism-prevents-obesity-induced-cerebral-artery-remodeling-and-reduces-white-matter-injury-in-rats
#12
Paulo Wagner Pires, Jonathon Lee McClain, Sebastian F Hayoz, Anne McLaren Dorrance
Midlife obesity is a risk factor for dementia development. Obesity has also been linked to hyperaldosteronism, and this can be modeled in rats by high fat (HF) feeding from weaning. Aldosterone, or activation of the mineralocorticoid receptor (MR) causes cerebrovascular injury in lean hypertensive rats. We hypothesized that rats fed a HF diet would show inward middle cerebral artery (MCA) remodeling that could be prevented by MR antagonism. We further proposed that the cerebral artery remodeling would be associated with white mater injury...
May 14, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29754402/impact-of-mean-arterial-pressure-on-sublingual-microcirculation-during-cardiopulmonary-bypass-secondary-outcome-from-a-randomised-clinical-trial
#13
Frederik Holmgaard, Anne G Vedel, Hanne Berg Ravn, Jens C Nilsson, Lars S Rasmussen
OBJECTIVE: In this substudy of a randomised, clinical trial, we explored the sublingual microcirculation during cardiac surgery at two different levels of blood pressure. We hypothesised that a higher mean arterial pressure during cardiopulmonary bypass would cause higher Microvascular Flow Index. METHODS: Thirty-six cardiac surgery patients undergoing coronary artery bypass grafting were included and randomised to either low (40-50 mmHg) or high (70-80 mmHg) mean arterial pressure during cardiopulmonary bypass...
May 13, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29734516/dermal-capillary-rarefaction-as-a-marker-of-microvascular-damage-in-patients-with-rheumatoid-arthritis-association-with-inflammation-and-disorders-of-the-macrocirculation
#14
Panagiota Anyfanti, Eugenia Gkaliagkousi, Areti Triantafyllou, Xenophon Zabulis, Panagiotis Dolgyras, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
OBJECTIVE: Capillary rarefaction is observed in various cardiovascular diseases, yet it remains understudied in RA, a chronic inflammatory disease accompanied by excess cardiovascular risk. We quantified capillary density in RA patients and explored potential associations with macrocirculatory disorders, inflammation, and cardiovascular risk. METHODS: Dermal capillary density was assessed with nailfold capillaroscopy in RA and non-RA individuals, using specifically designed semiautomated software...
May 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29729094/pulse-wave-velocity-in-the-microcirculation-reflects-both-vascular-compliance-and-resistance-insights-from-computational-approaches
#15
Qing Pan, Ruofan Wang, Bettina Reglin, Luping Fang, Jing Yan, Guolong Cai, Wolfgang M Kuebler, Axel R Pries, Gangmin Ning
OBJECTIVE: PWV is the speed of pulse wave propagation through the circulatory system. mPWV emerges as a novel indicator of hypertension, yet it remains unclear how different vascular properties affect mPWV. We aim to identify the biomechanical determinants of mPWV. METHODS: A 1D model was used to simulate PWV in a rat mesenteric microvascular network and, for comparison, in a human macrovascular arterial network. Sensitivity analysis was performed to assess the relationship between PWV and vascular compliance and resistance...
May 5, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29701894/fluorescent-labeling-of-endogenous-platelets-for-intravital-microscopy-effects-on-platelet-function
#16
Qi Da, Paul J Derry, Fong W Lam, Rolando E Rumbaut
OBJECTIVE: Monitoring endogenous platelets during intravital microscopy often involves two approaches: fluorescently labeled antibodies or genetic models of platelet-specific fluorescent protein expression. Due to limited data available on platelet functional changes induced by these methods, we compared functional effects of these methods on platelets. METHODS: Platelet aggregation to collagen and thrombin, and collagen matrix-mediated platelet adhesion/aggregation under flow were tested...
April 27, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29665185/laminar-shear-stress-modulates-endothelial-luminal-surface-stiffness-in-a-tissue-specific-manner
#17
Nick Merna, Andrew K Wong, Victor Barahona, Pierre Llanos, Balvir Kunar, Brisa Palikuqi, Michael Ginsberg, Shahin Rafii, Sina Y Rabbany
OBJECTIVE: Endothelial cells form vascular beds in all organs and are exposed to a range of mechanical forces that regulate cellular phenotype. We sought to determine the role of endothelial luminal surface stiffness in tissue-specific mechanotransduction of laminar shear stress in microvascular mouse cells and the role of arachidonic acid in mediating this response. METHODS: Microvascular mouse endothelial cells were subjected to laminar shear stress at 4 dynes/cm2 for 12 hours in parallel plate flow chambers that enabled real-time optical microscopy and atomic force microscopy measurements of cell stiffness...
April 17, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29665152/endothelium-dependent-hyperpolarization-mediated-vasodilatation-compensates-nitric-oxide-mediated-endothelial-dysfunction-during-ischemia-in-diabetes-induced-canine-coronary-collateral-microcirculation-in-vivo
#18
Toyotaka Yada, Hiroaki Shimokawa, Hiroyuki Tachibana
OBJECTIVES: It has been previously demonstrated that endothelial caveolin-1 plays crucial roles to produce an endothelium-derived hyperpolarizing factor in mouse mesenteric arteries. We examined whether this mechanism is involved in the endothelium-dependent hyperpolarization-mediated responses to compensate reduced NO-mediated responses in diabetes mellitus during coronary occlusion in dogs in vivo. METHODS: Canine subepicardial collateral coronary small arteries (≥100 μm) and arterioles (<100 μm) were observed by an intravital microscope...
April 17, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29608790/increase-in-perfused-boundary-region-of-endothelial-glycocalyx-is-associated-with-higher-prevalence-of-ischemic-heart-disease-and-lesions-of-microcirculation-and-vascular-wall
#19
Alexander Y Gorshkov, Marina V Klimushina, Sergei A Boytsov, Alexander Y Kots, Nadezhda G Gumanova
OBJECTIVE: PBR characterizes penetration of red blood cells inside glycocalyx and its thickness can have profound impact on microcirculation and other vascular parameters. The goal of our study was to reliably quantify PBR and assess its potential use as a new marker of cardiovascular pathology. METHODS: The study included 208 patients (123 men and 85 women from 40 to 65 years of age) with various grades of cardiovascular SCORE risk index and IHD. PBR was quantified by sidestream dark field capillaroscopy with green light excitation...
May 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29602193/microvascular-endothelial-function-is-an-independent-predictor-for-albuminuria-progression-among-asians-with-type-2-diabetes-a-prospective-cohort-study
#20
Xiao Zhang, Serena Low, Keven Ang, Lee Ying Yeoh, Subramaniam Tavintharan, Chee Fang Sum, Su Chi Lim
OBJECTIVE: We aim to investigate whether microvascular endothelial dysfunction is an independent predictor for future albuminuria progression in T2DM cohort. METHODS: A total of 1098 patients with T2DM were clinically assessed at baseline and 3.2-year follow-up. Progression was defined as transition from normoalbuminuria (ACR <30 mg/g) to microalbuminuria (ACR = 30-299 mg/g) or macroalbuminuria (ACR >300 mg/g), or microalbuminuria to macroalbuminuria...
May 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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