journal
MENU ▼
Read by QxMD icon Read
search

Microcirculation: the Official Journal of the Microcirculatory Society, Inc

journal
https://www.readbyqxmd.com/read/28985443/kv-channels-and-the-regulation-of-vascular-smooth-muscle-tone
#1
William F Jackson
Vascular smooth muscle cells (VSMCs) in resistance arteries and arterioles express a diverse array of voltage-gated K(+) (KV ) channels with members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the KV channel family: 1.) are highly expressed in VSMCs; 2.) are active at the resting membrane potential of VSMCs in vivo (-45 to -30 mV); 3.) contribute to the negative feedback regulation of VSMC membrane potential and myogenic tone; 4.) are activated by cAMP-related vasodilators, hydrogen sulfide and hydrogen peroxide; 5...
October 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28976052/kv7-potassium-channels-as-signal-transduction-intermediates-in-the-control-of-microvascular-tone
#2
Kenneth L Byron, Lyubov I Brueggemann
Potassium channels are recognized as important regulators of cellular functions in most, if not all cell types. These cellular proteins assemble to form gated pores in the plasma membrane, which serve to regulate the flow of potassium ions (K(+) ) from the cytosol to the extracellular space. In vascular smooth muscle cells (VSMCs), the open state of potassium channels enables the efflux of K(+) and thereby establishes a negative resting voltage across the plasma membrane that inhibits the opening of voltage-sensitive Ca(2+) channels (VSCCs)...
October 4, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28976050/assessment-of-the-test-retest-reliability-of-human-gingival-blood-flow-measurements-by-laser-speckle-contrast-imaging-in-a-healthy-cohort
#3
Eszter Molnár, Réka Fazekas, Zsolt Lohinai, Zsuzsanna Tóth, János Vág
OBJECTIVES: The reliability of gingival blood flow measured by Laser Speckle Contrast Imaging is unknown. Our aim was to investigate the effect of factors inherent in oral mucosa measurement on intra-day and inter-day reliability. METHODS: Gingival blood flow was measured in seventy healthy subjects. First, measurements were obtained by varying the incidence angle of imaging, using a lip retractor. Second, three snapshots were taken with closure of the mouth in-between and lips were retracted by a dental mirror...
October 4, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28963858/kv-channel-trafficking-and-control-of-vascular-tone
#4
Raquibul Hasan, Jonathan H Jaggar
Membrane potential is a principal regulator of arterial contractility. Arterial smooth muscle cells express several different types of ion channel that control membrane potential, including voltage-gated K(+) (KV ) channels. KV channel activation leads to membrane hyperpolarization, resulting in inhibition of voltage-dependent calcium (Ca(2+) ) channels, a reduction in intracellular Ca(2+) concentration ([Ca(2+) ]i ) and vasodilation. In contrast, KV channel inhibition leads to membrane depolarization and vasoconstriction...
September 30, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28926162/retinal-vessel-morphology-in-rheumatoid-arthritis-association-with-systemic-inflammation-subclinical-atherosclerosis-and-cardiovascular-risk
#5
Panagiota Anyfanti, Areti Triantafyllou, Eugenia Gkaliagkousi, Nikolaos Koletsos, Georgios Athanasopoulos, Xenophon Zabulis, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
OBJECTIVE: Quantification of retinal vessel morphology has emerged as a marker of cardiovascular health. We examined retinal microvascular diameters in RA, particularly in regard with systemic inflammation, subclinical atherosclerosis and cardiovascular risk. METHODS: Retinal images from RA patients and controls were processed using computerized software, to obtain central retinal arteriolar (CRAE) and venular (CRVE) equivalent and arteriovenous ratio (AVR). Subclinical atherosclerosis was assessed with carotid intima-media thickness (cIMT), and 10-year risk of general cardiovascular disease was calculated...
September 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28865157/acute-simvastatin-treatment-restores-cerebral-functional-capillary-density-and-attenuates-angiotensin-ii-induced-microcirculatory-changes-in-a-model-of-primary-hypertension
#6
Felipe Freitas, Vanessa Estato, Patricia Reis, Hugo C Castro-Faria-Neto, Vinícius Carvalho, Rafael Torres, Marcos A Lessa, Eduardo Tibiriçá
OBJECTIVE: We investigated the acute effects of simvastatin on cerebral microvascular rarefaction and dysfunction in spontaneously hypertensive rats (SHRs). METHODS: Male Wistar Kyoto rats (WKY) and SHRs were divided into 4 groups of 8 animals each: WKY-CTL and SHR-CTL, treated with 0.9% saline; and WKY+SIM and SHR+SIM, treated with simvastatin (30 mg/kg/day) for 3 days by gavage. Cerebral functional capillary density (FCD) was assessed by intravital fluorescence videomicroscopy...
September 2, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28857417/increased-myoendothelial-feedback-is-associated-with-increased-connexin37-and-ik1-channel-expression-in-mesenteric-arteries-of-diet-induced-hyperhomocysteinemic-mice
#7
Robin C Looft-Wilson, Cara R Goodell, Christina A Mutch, Stephanie M Mutchler, Kayla L Miller, Monique Guraya
OBJECTIVE: Previously, we found that diet-induced HHcy in mice caused decreased eNOS expression and signaling in mesenteric arteries, but greatly enhanced non-NOS, non-prostacyclin-dependent vasodilation, which involves myoendothelial gap junction (MEJ) communication. To further assess whether HHcy enhances MEJ communication, this study examined endothelium-dependent attenuation of phenylephrine-induced vasoconstriction (myoendothelial feedback) and key molecules involved. METHODS: Myoendothelial feedback was examined in isolated mouse mesenteric arteries, after 6-wk diet-induced HHcy, using pressure myography...
August 31, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28857373/effect-of-direct-cold-atmospheric-plasma-dicap-on-microcirculation-of-intact-skin-in-a-controlled-mechanical-environment
#8
Thomas Borchardt, Jennifer Ernst, Andreas Helmke, Murat Tanyeli, Arndt F Schilling, Gunther Felmerer, Wolfgang Viöl
OBJECTIVE: The microcirculatory response of intact human skin to exposure with direct cold atmospheric plasma (diCAP) for different durations with a focus on the effect of implied mechanical pressure during plasma treatment was investigated. METHODS: Local relative hemoglobin, blood flow velocity, tissue oxygen saturation and blood flow were monitored non-invasively for up to 1 h in 1-2 mm depth by optical techniques, as well as temperature, pH values and moisture before and after skin stimulation...
August 31, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28801994/influence-of-feeding-hematocrit-and-perfusion-pressure-on-hematocrit-reduction-f%C3%A3-hraeus-effect-in-an-artificial-microvascular-network
#9
Walter H Reinhart, Nathaniel Z Piety, Sergey S Shevkoplyas
OBJECTIVE: Hematocrit in narrow vessels is reduced due to concentration of fast flowing red blood cells (RBC) in the center, and of slower flowing plasma along the wall of the vessel, which in combination with plasma skimming at bifurcations leads to the striking heterogeneity of local hematocrit in branching capillary networks known as the network Fåhraeus effect. We analyzed the influence of feeding hematocrit and perfusion pressure on the Fåhraeus effect in an artificial microvascular network (AMVN)...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28801985/between-day-reliability-of-local-thermal-hyperaemia-in-the-forearm-and-index-finger-using-single-point-laser-doppler-flowmetry
#10
Gregory W McGarr, Gary J Hodges, Stephen S Cheung
OBJECTIVE: To assess between-day reliability for local thermal hyperaemia (LTH) in glabrous and non-glabrous index finger skin and non-glabrous forearm skin, with single point laser-Doppler flowmetry. METHODS: Part-1: In healthy, habitually active males (n=10), LTH was examined twice (~7-10 d apart) for both skin types on the index finger. Part-2: Identical testing was performed on the volar forearm. Local heating (33-42°C at 1°C·20 s(-1) +20 min at 44°C) was performed at all skin sites and baseline, initial peak, and plateau phases were identified...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28791758/agent-based-computational-model-of-retinal-angiogenesis-simulates-microvascular-network-morphology-as-a-function-of-pericyte-coverage
#11
Joseph Walpole, Feilim Mac Gabhann, Shayn M Peirce, John C Chappell
OBJECTIVE: Define a role for perivascular cells during developmental retinal angiogenesis in the context of endothelial cell Notch1-DLL4 signaling at the multicellular network level. METHODS: The retinal vasculature is highly sensitive to growth factor mediated intercellular signaling. Although endothelial cell signaling has been explored in detail, it remains unclear how pericytes function to modulate these signals that lead to a diverse set of vascular network patterns in health and disease...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28791754/endothelial-precursor-cells-stimulate-pericyte-like-coverage-of-bone-marrow-derived-mesenchymal-stem-cells-through-pdgf-bb-induction-which-is-enhanced-by-substance-p
#12
Mingzi Zhang, Woosung Ahn, Sumin Kim, Hyun Sook Hong, Chengshi Quan, Youngsook Son
OBJECTIVE: The aim of this study was to evaluate the angiogenicity of a combination of bone marrow-derived endothelial precursor cells (BM-EPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) in vitro in the presence of substance P (SP), and its working mechanism. METHODS: BM-MSCs and BM-EPCs were co-cultured with or without SP. ELISA and RT-PCR were performed to detect angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-BB)...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28787770/dosing-of-indocyanine-green-for-intraoperative-laser-fluorescence-angiography-in-kidney-transplantation
#13
Ulrich Rother, Andreas L H Gerken, Ioannis Karampinis, Madeline Klumpp, Susanne Regus, Alexander Meyer, Hendrik Apel, Bernhard K Krämer, Karl Hilgers, Werner Lang, Kai Nowak
OBJECTIVE: Sufficient blood supply is a crucial factor determining postoperative allograft function in kidney transplantation. Therefore, besides the surgeon's individual impression a method for evaluating the quality of the organ's microperfusion is required. Laser fluorescence angiography with indocyanine-green (ICG) is an emerging tool for this purpose. However, no reproducible quantification of ICG fluorescence has been performed in transplantation so far. METHODS: This retrospective two-center study was designed to evaluate the dosing of ICG for intraoperative laser fluorescence angiography in kidney transplantation...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28510992/lymph-node-effective-vascular-permeability-and-chemotherapy-uptake
#14
Eelco F J Meijer, Cedric Blatter, Ivy X Chen, Echoe Bouta, Dennis Jones, Ethel R Pereira, Keehoon Jung, Benjamin J Vakoc, James W Baish, Timothy P Padera
OBJECTIVE: Lymph node metastases are a poor prognostic factor. Additionally, responses of lymph node metastasis to therapy can be different from the primary tumor. Investigating the physiologic lymph node blood vasculature might give insight into the ability of systemic drugs to penetrate the lymph node, and thus into the differential effect of therapy between lymph node metastasis and primary tumors. Here, we measured effective vascular permeability of lymph node blood vessels and attempted to increase chemotherapy penetration by increasing effective vascular permeability...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28480622/roles-of-nadph-oxidase-and-mitochondria-in-flow-induced-vasodilation-of-human-adipose-arterioles-ros-induced-ros-release-in-coronary-artery-disease
#15
Natalya S Zinkevich, Ibra S Fancher, David D Gutterman, Shane A Phillips
OBJECTIVES: H2 O2 contributes to FID of human arterioles. This study is designed to examine the roles of mitochondria and NADPH oxidase in modulating the release of ROS and in mediating FID. We tested whether NADPH oxidase contributes to mitochondrial ROS generation in arterioles during CAD. METHODS: Visceral adipose arterioles obtained from patients with or without CAD were cannulated and pressurized for videomicroscopic measurement of arteriolar diameters. Dilator responses and ROS production during flow were determined in the presence and absence of the NADPH oxidase inhibitor gp91ds-tat and the mitochondrial electron transport inhibitor rotenone...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28477419/the-impact-of-endotoxin-on-jejunal-tissue-oxygenation
#16
Werner Pajk, Karl-Heinz Stadlbauer, Axel Kleinsasser, Oskar Kotzinger, Hanno Ulmer, Walter Hasibeder, Hans Knotzer
OBJECTIVE: We examined the effects of systemic ETX on jejunal mucoal microcirculatory parameters in anesthetized pigs. METHODS: Jejunal mucosal tissue PO2 was measured employing Clark-type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28370794/short-term-48%C3%A2-hours-intravenous-serelaxin-infusion-has-no-effect-on-myogenic-tone-or-vascular-remodeling-in-rat-mesenteric-arteries
#17
Maria Jelinic, Chen Huei Leo, Sarah A Marshall, Sevvandi N Senadheera, Laura J Parry, Marianne Tare
BACKGROUND: Short-term IV sRLX (recombinant human relaxin-2) infusion enhances endothelium-dependent relaxation in mesenteric arteries. This is initially underpinned by increased NO followed by a transition to prostacyclin. The effects of short-term IV sRLX treatment on pressure-induced myogenic tone and vascular remodeling in these arteries are unknown. Therefore, we investigated the effects of sRLX infusion on pressure-induced myogenic tone and passive mechanical wall properties in mesenteric arteries...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28296053/vasoactive-effect-of-fibronectin-derived-epiviosamine-1-and-related-peptides-in-quiescent-and-stress-models
#18
Mary D Frame, Fubao Lin, Anthony M Dewar, Richard A F Clark
OBJECTIVE: Following thermal burn injury, plasma fibronectin degrades within the interstitium; one possible product is EVA-1, PSHISKYILRWRPK found within the FNIII1 . EVA-1 ameliorates thermal burn injury progression, and binds to and enhances PDGF-BB in promoting cell metabolism, growth and survival; shorter related peptides lose these abilities. Here we study the effect of EVA-1 and shorter peptides for their vasoactivity under quiescent and stress conditions. METHODS: Using the hamster cheek pouch intravital microscopy model, five EVA-1 related peptides were applied to small arterioles via micropipette (10(-16) -10(-4) mol L(-1) ) in quiescent tissue and after defined stress: nitric oxide or heat...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28261893/astrocyte-activation-and-capillary-remodeling-in-modified-bilateral-common-carotid-artery-occlusion-mice
#19
Jiangman Song, Di Nan, Qihua He, Lu Yang, Huailian Guo
OBJECTIVE: The cerebral ischemia leads to brain dysfunction with neuron degeneration and responses from astrocytes and vessels. The aim of this study was to study the changes of astrocyte and microvessel in modified BCCAO mice. METHODS: Adult transgenic Tie2-GFP mice were subjected to modified BCCAO operation and cranial window implantation. CBF and neurological injury were examined after ischemia. Astrocytes and vessels were investigated by two-photon laser-scanning microscope and confocal laser-scanning microscope in vivo...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28236639/pericyte-modulation-by-a-functional-antibody-obtained-by-a-novel-single-cell-selection-strategy
#20
Jesper Just, Simon Lykkemark, Charlotte H Nielsen, Ali R Roshenas, Kim R Drasbek, Steen V Petersen, Toke Bek, Peter Kristensen
OBJECTIVE: Pericytes surround the endothelial cells of the microvasculature where they serve as active participants in crucial vascular functions such as angiogenesis, stability, and permeability. However, pericyte loss or dysfunction has been described in a number of pathologies. Targeting pericytes could therefore prove instrumental in the further development of vascular therapeutics. METHODS: To target the pericyte, a proteomic-based approach using antibody phage display was conducted...
August 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
journal
journal
32012
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"