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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://www.readbyqxmd.com/read/30099828/abstracts-from-the-43rd-annual-meeting-of-japanese-society-for-microcirculation
#1
Mayumi Kajimura
I am going to present my 38 years of research. We contributed to the development of two-point fluorophotometry and developed the Laser Doppler flowmeter, as well as the Doppler OCT flowmeter. I will also demonstrate how we have contributed to the international community through our experience and expertise in measuring ocular circulation. This article is protected by copyright. All rights reserved.
August 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30040171/the-contribution-of-carbon-monoxide-to-vascular-tonus
#2
Günnur Koçer, Seher Nasircilar Ülker, Ümit Kemal Şentürk
OBJECTIVE: The aim of this descriptive study is to examine the contribution of CO in the maintenance of vascular tonus in different organs and different vessel segments; the underlying mechanism of CO-induced vasodilation was investigated. METHODS: Sixty Wistar albino rats, aged 6-8 months, were used in this study. Response to CO by isolated arteries from thoracic and abdominal aorta and mesenteric, renal, gastrocnemius, and gracilis muscles as well as heart, lung, and brain vascular beds was endogenously and exogenously studied using organ baths or myograph...
July 24, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30030943/arteriolar-and-capillary-responses-to-co-2-and-h-in-hamster-skeletal-muscle-microvasculature-implications-for-active-hyperaemia
#3
Mackenzie E Charter, Iain R Lamb, Coral L Murrant
OBJECTIVE: We hypothesized that carbon dioxide (CO2 ) and hydrogen ion (H+ ) stimulate capillaries and arterioles to produce local and conducted vasodilations required to coordinate the distribution of blood flow to contracting skeletal muscle fibres. METHODS: CO2 and H+ independently and in combination were applied to 2A arterioles (first branch order from the 1A feed arteriole) and capillaries of the in situ, blood perfused hamster cremaster muscle. The resulting local and conducted vasodilations were measured...
July 21, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30030876/the-pulmonary-microvasculature-entraps-induced-vascular-progenitor-cells-ivpcs-systemically-delivered-after-cardiac-ischemia-reperfusion-injury-indication-for-preservation-of-heart-function-via-paracrine-effects-beyond-engraftment
#4
Melanie Ziegler, Katharina Haigh, Thao Nguyen, Xiaowei Wang, Bock Lim, May Lin Yap, Eleanor M Eddy, Jody J Haigh, Karlheinz Peter
OBJECTIVE: Stem cell-based regenerative therapies have been intensively studied with the aim to define an ideal cell type for the treatment of myocardial infarction. We tested systemically delivered, platelet-targeted induced vascular progenitor cells (iVPCs) to study their potential to salvage damaged myocardium after ischemia-reperfusion injury. METHODS: Using a mouse model of ischemia-reperfusion injury, we tested the potential of platelet-targeted iVPCs (1x106 targ-iVPCs) compared to non-targ-iVPCs and a saline control...
July 21, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30027659/reversible-impairment-of-coronary-flow-reserve-in-acute-myocarditis
#5
Joerg Kellermair, Daniel Kiblboeck, Hermann Blessberger, Juergen Kammler, Christian Reiter, Clemens Steinwender
OBJECTIVE: Acute myocarditis is accompanied by an impaired coronary microcirculation. These microcirculatory disturbances are not well defined, and data are derived from complex invasive measurements. Therefore, this study aimed to evaluate the inflammation-induced microcirculatory dysfunction including its reversibility and association with markers of inflammation severity (extent of LGE on CMR imaging and laboratory markers of myocardial necrosis) using the noninvasive technique of echocardiographic CFR measurement...
July 20, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30025187/insulin-resistance-disrupts-cell-integrity-mitochondrial-function-and-inflammatory-signaling-in-lymphatic-endothelium
#6
Yang Lee, Sanjukta Chakraborty, Cynthia J Meininger, Mariappan Muthuchamy
OBJECTIVE: Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects the metabolic function of cells, and consequently impairs tissue function. We hypothesized that insulin resistance in lymphatic endothelial cells (LECs) decreases eNOS activity, disrupts barrier integrity increases permeability, and activates mitochondrial dysfunction and pro-inflammatory signaling pathways...
July 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29999581/ovarian-hormones-modulate-endothelin-1-receptor-responses-in-young-women
#7
Kelly N Sebzda, Andrew V Kuczmarski, Ryan T Pohlig, Shannon L Lennon, David G Edwards, Megan M Wenner
OBJECTIVE: We recently demonstrated ETBR mediate vasodilation in young but not postmenopausal women; it is unclear if this is related to age or a decline in ovarian hormones. The purpose of this study was to test the hypothesis that ETBR responses are modulated by ovarian hormones. METHODS: We measured cutaneous vasodilatory responses in 12 young women (22 ± 1 years, 23 ± 1 kg/m2 ) during the ML (days 20-25) and EF (days 2-5) phases of the menstrual cycle...
July 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29964354/abstracts-of-the-68-th-annual-meeting-in-university-of-nottingham
#8
Melissa Gammons
Placental hypervascularization observed in gestational diabetes mellitus (GDM) may be related to functional availability of vascular endothelial growth factor (VEGF) and its receptors. We aimed to test whether changes in phosphorylation of tyrosine 951 or tyrosine 1175 (pY951 or pY1175) of the vascular endothelial growth factor receptor 2 (VEGFR2) are associated with the proangiogenic state observed in placentas from GDM This article is protected by copyright. All rights reserved.
July 2, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29956866/utilizing-state-of-the-art-omics-technology-and-bioinformatics-to-identify-new-biological-mechanisms-and-biomarkers-for-coronary-artery-disease
#9
REVIEW
Stephen T Vernon, Thomas Hansen, Katharine A Kott, Jean Y Yang, John F O'Sullivan, Gemma A Figtree
Identification of the four standard modifiable cardiovascular risk factors (SMuRFs)-diabetes mellitus, hyperlipidaemia, hypertension, and cigarette smoking-has allowed the development of risk scores. These have been used in conjunction with primary and secondary prevention strategies targeting SMuRFs to reduce the burden of CAD. Recent studies show that up to 25% of ACS patients do not have any SMuRFs. Thus, SMuRFs do not explain the entire burden of CAD. There appears to be variation at the individual level rendering some individuals relatively susceptible or resilient to developing atherosclerosis...
June 29, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29924435/the-role-of-senescence-telomere-dysfunction-and-shelterin-in-vascular-aging
#10
Yu Liu, Samuel I Bloom, Anthony J Donato
In the United States and other westernized nations, cardiovascular diseases (CVDs) are the leading cause of death in adults over 65 years of age. Large artery stiffness and endothelial dysfunction are increased with age and age-associated arterial dysfunction is an important antecedent of CVDs. One age-associated change that may contribute to vascular dysfunction and CVD risk is an increase in the number of resident senescence cells in the vasculature. Senescent cells display a pro-oxidant, pro-inflammatory phenotype known as the senescence associated secretory phenotype (SASP)...
June 20, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29923664/differential-arterial-and-venous-endothelial-redox-responses-to-oxidative-stress
#11
Bandana Shrestha, Priya K Prasai, Amir M Kaskas, Ankur Khanna, Vijay Letchuman, Sunjay Letchuman, Jonathan Steven Alexander, A Wayne Orr, Matthew D Woolard, Christopher B Pattillo
OBJECTIVE: Oxidative stress is a central event linked with endothelial dysfunction and inflammation in several vascular pathologies, marked by over-production of ROS and concomitant decreases in antioxidants, for example GSH. Here, we distinguish endothelial oxidative stress regulation and associated functional disparities in the two main vascular conduits, (arteries and veins) following decreases in GSH. METHODS: MAECs and VCECs were used as models of arterial and venular endothelium, respectively, and BSO (0-100 μmol/L) was used to indirectly increase cellular oxidative stress...
June 20, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29923276/extracellular-vesicles-and-microvascular-pathology-decoding-the-active-dialogue
#12
REVIEW
Elham Hosseini-Beheshti, Georges E R Grau
Extracellular vesicles (EV) are a heterogeneous collection of membrane-surrounded structures released from all studied cells, under both physiological and pathological conditions. These nano-size vesicles carry complex cargoes including different classes of proteins, lipids and nucleic acids and are known to act as a communication and signalling vesicles in various cellular process. In addition to their role in development and progression of pathological disorders which make them potentially great biomarkers, EV have beneficial effects, as they take part in homeostasis...
June 20, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908049/imaging-sublingual-microcirculatory-perfusion-in-pediatric-patients-receiving-procedural-sedation-with-propofol-a-pilot-study
#13
Maaike A Riedijk, Dan M J Milstein
OBJECTIVE: Procedural sedation with propofol is widely used in the pediatric population. A well-known side effect of propofol is a decrease in peripheral vascular resistance resulting in hypotension, but little is known about the effects on microcirculation in humans. We aimed to evaluate the effects of propofol on the sublingual microcirculatory perfusion by continuous video imaging in pediatric patients undergoing procedural sedation. METHODS: Patients admitted to the Pediatric Intensive Care Unit for procedural sedation were recruited...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908046/sepsis-induced-acute-kidney-injury-a-disease-of-the-microcirculation
#14
REVIEW
Shuai Ma, Roger G Evans, Naoya Iguchi, Marianne Tare, Helena C Parkington, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva
AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The pathogenesis of septic AKI is complex, but there is emerging evidence that, at least in the first 48 hours, the defects may be functional rather than structural in nature. For example, septic AKI is associated with an absence of histopathological changes, but with microvascular abnormalities and tubular stress. In this context, renal medullary hypoxia due to redistribution of intra-renal perfusion is emerging as a critical mediator of septic AKI...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908041/automated-quantification-of-microvascular-perfusion
#15
Penn Mason McClatchey, Nicholas A Mignemi, Zhengang Xu, Ian M Williams, Jane E B Reusch, Owen P McGuinness, David H Wasserman
OBJECTIVE: Changes in microvascular perfusion have been reported in many diseases, yet the functional significance of altered perfusion is often difficult to determine. This is partly because commonly used techniques for perfusion measurement often rely on either indirect or by-hand approaches. METHODS: We developed and validated a fully automated software technique to measure microvascular perfusion in videos acquired by fluorescence microscopy in the mouse gastrocnemius...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29885064/a-dynamic-computational-network-model-for-the-role-of-nitric-oxide-and-the-myogenic-response-in-microvascular-flow-regulation
#16
Yien Liu, Donald G Buerk, Kenneth A Barbee, Dov Jaron
OBJECTIVES: The effect of NO on smooth muscle cell contractility is crucial in regulating vascular tone, blood flow, and O2 delivery. Quantitative predictions for interactions between the NO production rate and the myogenic response for microcirculatory blood vessels are lacking. METHODS: We developed a computational model of a branching microcirculatory network with four representative classes of resistance vessels to predict the effect of endothelium-derived NO on the microvascular pressure-flow response...
June 8, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29876993/from-pregnancy-to-cardiovascular-disease-lessons-from-relaxin-deficient-animals-to-understand-relaxin-actions-in-the-vascular-system
#17
Maria Jelinic, Sarah A Marshall, Chen H Leo, Laura J Parry, Marianne Tare
Early maternal vascular adaptations to pregnancy are predominantly driven by changes in vascular tone, reactivity, and remodeling. Failure of the maternal systemic vasculature to adapt sufficiently can lead to serious complications of pregnancy. The hormone relaxin is widely recognized for its contribution to the essential renal and systemic hemodynamic adaptations in early pregnancy through direct actions on the maternal vasculature. Studies in relaxin gene knockout mice revealed that endogenous relaxin is not only a "pregnancy hormone" but has pleiotropic actions in various tissues in males and non-pregnant females...
June 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29846990/aging-and-vascular-related-pathologies
#18
REVIEW
Shu Wen Wen, Connie H Y Wong
Our aging population is set to grow considerably in the coming decades. In fact, the number of individuals older than 65 years will double by 2050. This projected increase in people living with extended life expectancy represents an inevitable upsurge in the presentation of age-related pathologies. However, our current understanding of the impact of aging on a number of biological processes is unfortunately inadequate. Cardiovascular, cerebrovascular, and neurodegenerative diseases are particularly prevalent in the elderly population...
May 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29846993/aging-attenuates-adenosine-triphosphate-induced-but-not-muscarinic-and-nicotinic-cutaneous-vasodilation-in-men
#19
Naoto Fujii, Takeshi Nishiyasu, Ronald J Sigal, Pierre Boulay, Gregory W McGarr, Glen P Kenny
OBJECTIVE: We evaluated the hypothesis that aging attenuates muscarinic, nicotinic, and ATP-related cutaneous vasodilation. METHODS: In 11 young (24 ± 4 years) and 11 older males (61 ± 8 years), CVC was assessed at 3 forearm skin sites that were infused with either: (i) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 mmol/L), (ii) nicotine (nicotinic receptor agonist, 5 doses: 1.2, 3.6, 11, 33, 100 mmol/L), or (iii) ATP (purinergic receptor agonist, 5 doses: 0...
July 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29770525/establishment-and-characterization-of-an-embryonic-pericyte-cell-line
#20
Huaning Zhao, Jordan Darden, John C Chappell
OBJECTIVE: Pericytes are specialized perivascular cells embedded within the basement membrane. These cells envelope the abluminal surface of endothelial cells and promote microvessel homeostasis. Recent discoveries of unique pericyte functions, particularly in neural tissues, underscore the need for overcoming existing challenges in establishing a functionally validated pericyte cell line. Here, we present methodologies for addressing these challenges as well as an embryonic pericyte cell line for use with in vitro and ex vivo experimental models...
July 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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