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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://www.readbyqxmd.com/read/29665185/laminar-shear-stress-modulates-endothelial-luminal-surface-stiffness-in-a-tissue-specific-manner
#1
Nick Merna, Andrew K Wong, Victor Barahona, Pierre Llanos, Balvir Kunar, Brisa Palikuqi, Michael Ginsberg, Shahin Rafii, Sina Y Rabbany
OBJECTIVE: Endothelial cells form vascular beds in all organs and are exposed to a range of mechanical forces that regulate cellular phenotype. We sought to determine the role of endothelial luminal surface stiffness in tissue-specific mechanotransduction of laminar shear stress in microvascular mouse cells and the role of arachidonic acid in mediating this response. METHODS: Microvascular mouse endothelial cells were subjected to laminar shear stress at 4 dynes/cm2 for 12 hours in parallel plate flow chambers that enabled real-time optical microscopy and atomic force microscopy measurements of cell stiffness...
April 17, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29665152/endothelium-derived-hyperpolarization-mediated-vasodilatation-compensates-nitric-oxide-mediated-endothelial-dysfunction-during-ischemia-in-diabetes-induced-canine-coronary-collateral-microcirculation-in-vivo
#2
Toyotaka Yada, Hiroaki Shimokawa, Hiroyuki Tachibana
OBJECTIVES: It has been previously demonstrated that endothelial caveolin-1 plays crucial roles to produce an endothelium-derived hyperpolarizing factor in mouse mesenteric arteries. We examined whether this mechanism is involved in the endothelium-derived hyperpolarizing-mediated responses to compensate reduced NO-mediated responses in diabetes mellitus during coronary occlusion in dogs in vivo. METHODS: Canine subepicardial collateral coronary small arteries (≥100 μm) and arterioles (<100 μm) were observed by an intravital microscope...
April 17, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29608790/increase-in-perfused-boundary-region-of-endothelial-glycocalyx-is-associated-with-higher-prevalence-of-ischemic-heart-disease-and-lesions-of-microcirculation-and-vascular-wall
#3
Alexander Y Gorshkov, Marina V Klimushina, Sergei A Boytsov, Alexander Y Kots, Nadezhda G Gumanova
OBJECTIVE: Perfused boundary region (PBR) characterizes penetration of red blood cells inside glycocalyx and its thickness can have profound impact on microcirculation and other vascular parameters. The goal of our study was to reliably quantify PBR and assess its potential use as a new marker of cardiovascular pathology. METHODS: The study included 208 patients (123 men and 85 women from 40 to 65 years of age) with various grades of cardiovascular SCORE risk index and ischemic heart disease...
April 2, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29602193/microvascular-endothelial-function-is-an-independent-predictor-for-albuminuria-progression-among-asians-with-type-2-diabetes-a-prospective-cohort-study
#4
Xiao Zhang, Serena Low, Keven Ang, Yeoh Lee Ying, Subramaniam Tavintharan, Chee Fang Sum, Lim Su Chi
OBJECTIVES: We aim to investigate whether microvascular endothelial dysfunction is an independent predictor for future albuminuria progression in type 2 diabetes (T2DM) cohort. METHODS: 1,098 T2DM patients were clinically assessed at baseline and 3.2-year follow-up. Progression was defined as transition from normo- (albumin-to-creatinine ratio (ACR)<30mg/g) to microalbuminuria (ACR=30-299mg/g) or macroalbuminuria (ACR>300mg/g), or micro- to macroalbuminuria...
March 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29577514/gene-expression-profiles-of-ion-channels-and-receptors-in-mouse-resistance-arteries-effects-of-cell-type-vascular-bed-and-age
#5
Erika M Boerman, Sen Sidharth, Rebecca L Shaw, Trupti Joshi, Steven S Segal
OBJECTIVE: Receptors and ion channels of smooth muscle cells (SMCs) and endothelial cells (ECs) are integral to the regulation of vessel diameter and tissue blood flow. Physiological roles of ion channels and receptors in skeletal muscle and mesenteric arteries have been identified however their gene expression profiles are undefined. We tested the hypothesis that expression profiles for ion channels and receptors governing vascular reactivity vary with cell type, vascular bed and age...
March 25, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29575333/gene-expression-profiles-of-glucose-toxicity-exposed-islet-microvascular-endothelial-cells
#6
Mingming Liu, Wenbao Lu, Qunxing Hou, Bing Wang, Youming Sheng, Qingbin Wu, Bingwei Li, Xueting Liu, Xiaoyan Zhang, Ailing Li, Honggang Zhang, Ruijuan Xiu
OBJECTIVE: Islet microcirculation is mainly composed by islet microvascular endothelial cells (IMECs). The aim of the study was to investigate the differences in gene expression profiles of IMECs upon glucose toxicity exposure and insulin treatment. METHODS: IMECs were treated with 5.6 mM glucose, 35 mM glucose and 35 mM glucose plus 10-8 M insulin respectively. Gene expression profiles were determined by microarray and verified by qPCR. GO terms and KEGG analysis were performed to assess the potential roles of differentially expressed genes...
March 25, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29537711/in-systemic-sclerosis-microvascular-and-hands-digital-arteries-damage-correlates-with-serum-levels-of-endostatin
#7
Antonietta Gigante, Luca Navarini, Domenico Margiotta, Biagio Barbano, Antonella Afeltra, Edoardo Rosato
OBJECTIVES: In systemic sclerosis (SSc), vascular injury leads to endothelial dysfunction with reduced capillary blood flow and tissue hypoxia. In SSc the angiogenesis is impaired and implicated in the microvascular damage. In severe vascular damage VEGF is reduced and endostatin is increased. Aim of this study was to evaluate the correlation between endostatin serum levels and microvascular and digital arteries damage. METHODS: Seventeen SSc patients were enrolled in this study...
March 14, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29527781/automated-assessment-of-absolute-nailfold-capillary-number-on-videocapillaroscopic-images-proof-of-principle-and-validation-in-systemic-sclerosis
#8
Maurizio Cutolo, Amelia C Trombetta, Karin Melsens, Carmen Pizzorni, Alberto Sulli, Barbara Ruaro, Sabrina Paolino, Ellen Deschepper, Vanessa Smith
BACKGROUND: Absolute nailfold capillary number should be a putative biomarker in selected rheumatic diseases but could be time consuming and not highly repeatable. OBJECTIVE: To validate an automated software for absolute nailfold capillary number and density evaluation, on nailfold videocapillaroscopy (NVC) images in systemic sclerosis (SSc). METHODS: An automated software to count nailfold capillary number (AUTOCAPI) had been constructed, through an exploratory image set...
March 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29527776/sublingual-microcirculatory-alterations-in-cirrhotic-patients
#9
Esteban Gonzalez Ballerga, Mario Omar Pozo, Paolo Nahuel Rubatto Birri, Vanina Siham Kanoore Edul, Juan Antonio Sorda, Jorge Daruich, Arnaldo Dubin
OBJECTIVE: To assess sublingual microcirculation in cirrhotic patients and its relationship to spider angiomas, complications, and outcome. METHODS: Thirty-one cirrhotic patients were prospectively compared to 31 matched controls. Sublingual microcirculation was evaluated by videomicroscopy. We specifically looked for capillaries with increased red blood cell velocity, which was defined as a velocity higher than the percentile 100th of controls. RESULTS: Compared to controls, cirrhotic patients showed decreased total and perfused vascular density (14...
March 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29457313/modeling-the-hematocrit-distribution-in-microcirculatory-networks-a-quantitative-evaluation-of-a-phase-separation-model
#10
Peter M Rasmussen, Timothy W Secomb, Axel R Pries
OBJECTIVE: Theoretical models are essential tools for studying microcirculatory function. Recently, the validity of a well-established phase separation model was questioned and it was claimed that it produces problematically low hematocrit predictions and lack of red cells in small diameter vessels. We conducted a quantitative evaluation of this phase separation model to establish common ground for future research. METHODS: Model predictions were validated against a comprehensive data base with measurements from four mesenteric networks...
February 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29457306/functional-characterization-of-collaterals-in-the-human-gingiva-by-laser-speckle-contrast-imaging
#11
Réka Fazekas, Eszter Molnár, Zsolt Lohinai, Elek Dinya, Zsuzsanna Tóth, Péter Windisch, János Vág
OBJECTIVES: The rate of blood flow between the various areas of the gingiva in resting position and under challenge is unknown. In the present study, the Laser Speckle Contrast Imaging (LSCI) method was used to map spatial and temporal changes in gingival blood flow after transient compression. METHODS: Horizontal, vertical and papilla base compressions were applied on the attached gingiva in 21 healthy patients (13 women, 8 men). LSCI was used to determine dynamic changes in regional blood flow during a five-second occlusion interval and subsequent reperfusion for twenty minutes...
February 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29432661/is-pulmonary-vascular-disease-reversible-with-ppar-%C3%A9-agonists
#12
Peter Afdal, Antoine F AbdelMassih
Severe angio-obliterative pulmonary vascular disease (PAH) remains a disease characterized by great morbidity and shortened survival. Unfortunately, the only currently available treatments for angio-obliterative changes are palliative in the form of pulmonary vasodilators evolving from the phosphodiesterase inhibitor sildenafil to endothelin receptor antagonist: Bosentan; while the only definitive treatment is lung transplantation which remains dependent on the availability of donors and the transplant policies which vary widely from a country to another...
February 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29412499/substance-p-ameliorates-tumor-necrosis-factor-alpha-induced-endothelial-cell-dysfunction-by-regulating-enos-expression-in-vitro
#13
Jiyuan Piao, Hyun Sook Hong, Youngsook Son
OBJECTIVE: The aim of the present study was to explore the beneficial effects of SP on NO production and inflammation-induced vascular endothelium cell death. METHODS: To mimic the inflammatory environment, tumor necrosis factor alpha (TNF-α) was treated to human umbilical vein endothelial cells (HUVECs), and SP was added prior to TNF-α to determine its protective effect. WST-1 assay was performed to detect cell viability. NO level in conditioned medium was measured by Griess Reagent system...
February 7, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29377443/salvinorin-a-ameliorates-cerebral-vasospasm-through-activation-of-endothelial-nitric-oxide-synthase-in-a-rat-model-of-subarachnoid-hemorrhage
#14
Juan Sun, Yan Zhang, Jianfei Lu, Weiguang Zhang, Junhao Yan, Lei Yang, Changman Zhou, Renyu Liu, Chunhua Chen
OBJECTIVE: This study aimed to demonstrate the potential of salvinorin A (SA) for cerebral vasospasm after subarachnoid hemorrhage (SAH) and investigate mechanisms of therapeutic effect using rat SAH model. METHODS: Salvinorin A was injected intraperitoneally, and the neurobehavioral changes were observed at 12 hours, 24 hours, 48 hours, and 72 hours after SAH. Basilar artery was observed by magnetic resonance imaging (MRI). The inner diameter and thickness of basilar artery were measured...
April 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29356218/brain-oxygenation-with-a-non-vasoactive-perfluorocarbon-emulsion-in-a-rat-model-of-traumatic-brain-injury
#15
Rania Abutarboush, Saad H Mullah, Biswajit K Saha, Ashraful Haque, Peter B Walker, Chioma Aligbe, Georgina Pappas, Lam Thuy Vi Tran Ho, Francoise G Arnaud, Charles R Auker, Richard M McCarron, Anke H Scultetus, Paula Moon-Massat
OBJECTIVE: The aim of this study was to assess, in two experiments, the safety and efficacy of the PFC emulsion Oxycyte as an oxygen therapeutic for TBI to test the hypothesis that early administration of this oxygen-carrying fluid post-TBI would improve brain tissue oxygenation (Pbt O2 ). METHODS: The first experiment assessed the effects of Oxycyte on cerebral vasoactivity in healthy, uninjured rats using intravital microscopy. The second experiment investigated the effect of Oxycyte on cerebral Pbt O2 using the PQM in TBI model...
April 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29325214/a-spike-in-mechanotransductive-adenosine-triphosphate-release-from-red-blood-cells-in-microfluidic-constrictions-only-occurs-with-rare-donors
#16
Jordan E Mancuso, William D Ristenpart
OBJECTIVE: Wan et al (Proc Natl Acad Sci USA, 105, 2008, 16432) demonstrated that RBCs rapidly and transiently release a spike of 300% more ATP shortly downstream from a short microfluidic constriction where the cells experience a sudden increase in shear stress. More recent work by Cinar et al (Proc Natl Acad Sci USA, 112, 2015, 11783), however, yielded no evidence for a similar spike in ATP release downstream of the constriction. Our aim was to determine whether a transient spike in mechanotransduction is the typical response of RBCs to the sudden onset of increased shear...
April 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29247478/chinese-medicine-tongxinluo-capsule-alleviates-cerebral-microcirculatory-disturbances-in-ischemic-stroke-by-modulating-vascular-endothelial-function-and-inhibiting-leukocyte-endothelial-cell-interactions-in-mice-a-two-photon-laser-scanning-microscopy-study
#17
Shen Liu, Cong Wei, Ning Kang, Qilong He, Junqing Liang, Hongtao Wang, Liping Chang, Daohong Chen, Qiuyan Zhang, Chengcheng Chang, Junfang Zhang, Hong Ren, Yiling Wu
OBJECTIVE: The aim of this study was to examine the effect of TXL, a Chinese medicine prescription, on cerebral microcirculatory disturbances after pMCAO in mice using TPLSM and further explore the underlying mechanisms. METHODS: Adlut male C57BL/6J mice were subjected to pMCAO and orally administered with TXL (3.0, 1.5 and 0.75 g/kg/d) at 1, 3, and 21 hours after pMCAO. The following parameters were examined at 6 and 24 hours after pMCAO: neurological deficits, infarct volume, BBB permeability, cerebral microvessel structure, brain microcirculation (TPLSM imaging), vasoactive factors, and adhesion molecules...
February 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29210138/endovascular-shedding-markers-in-patients-with-heart-failure-with-reduced-ejection-fraction-results-from-a-single-center-exploratory-study
#18
Petra Nijst, Jirka Cops, Pieter Martens, Quirine Swennen, Matthias Dupont, Wai Hong W Tang, Wilfried Mullens
BACKGROUND: Endothelial glycocalyx degradation has been associated with multiple pathophysiological processes in cardiovascular disease. AIMS: To explore the role of glycocalyx shedding markers in pathophysiology of HFrEF. METHODS: In 123 HFrEF patients, the concentration, prognostic value, and association of glycocalyx shedding markers with other disease processes were investigated. RESULTS: Median HA levels and syndecan-1 levels in HFrEF patients were, respectively, 29...
February 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29210137/hyperoxia-does-not-affect-oxygen-delivery-in-healthy-volunteers-while-causing-a-decrease-in-sublingual-perfusion
#19
Bob Smit, Yvo M Smulders, Etto C Eringa, Harry P M M Gelissen, Armand R J Girbes, Harm-Jan S de Grooth, Hans H M Schotman, Peter G Scheffer, Heleen M Oudemans-van Straaten, Angelique M E Spoelstra-de Man
OBJECTIVE: To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. METHODS: Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Systemic hemodynamics were measured continuously by the volume-clamp method...
February 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29117630/biophysical-properties-of-microvascular-endothelium-requirements-for-initiating-and-conducting-electrical-signals
#20
Adam Kapela, Erik J Behringer, Steven S Segal, Nikolaos M Tsoukias
OBJECTIVE: Electrical signaling along the endothelium underlies spreading vasodilation and blood flow control. We use mathematical modeling to determine the electrical properties of the endothelium and gain insight into the biophysical determinants of electrical conduction. METHODS: Electrical conduction data along endothelial tubes (40 μm wide, 2.5 mm long) isolated from mouse skeletal muscle resistance arteries were analyzed using cable equations and a multicellular computational model...
February 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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