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Microcirculation: the Official Journal of the Microcirculatory Society, Inc

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https://www.readbyqxmd.com/read/28665547/effects-of-different-intensity-laser-acupuncture-at-two-adjacent-same-meridian-acupoints-on-nitric-oxide-and-soluble-guanylate-cyclase-releases-in-human
#1
Wan-Ling Jiang, Hua-Jiang Wei, Zhou-Yi Guo, Yi-Rong Ni, Hong-Qin Yang, Shu-Sen Xie
OBJECTIVES: The aim of this study was to detect the influences of laser acupuncture (LA) at non-acupoint and two adjacent acupoints of pericardium meridian on the releases of nitric oxide (NO) and soluble guanylate cyclase (sGC) in 20 healthy subjects. METHODS: Different intensities (12 mW, 24 mW, 48 mW) infrared laser were used for irradiating Jianshi (PC5), Ximen (PC4) acupoints and non-acupoint for 20 min, 40 min, respectively. Semi-circular tubes were taped to the skin surface and filled with NO-scavenging compound for 20 min to capture NO and sGC which were measured using spectrophotometry in a blinded fashion...
June 30, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28632939/acute-skin-trauma-induces-hyperemia-but-superficial-papillary-nutritive-perfusion-remains-unchanged
#2
Liv Kristin Sundheim, Ane Halse Sporastøyl, Torjus Wester, Göran Salerud, Knut Kvernebo
OBJECTIVES: Superficial skin papillary capillaries with blood supply from a superficial vascular plexus and regulated by local metabolic needs, supply oxygen and nutrient for epithelial cell proliferation. A deep vascular plexus regulated by autonomous nerves serves body thermoregulation. In healthy volunteers we assessed circulatory effects of a standardised skin trauma by computer assisted video m microscopy (CAVM), diffuse reflectance spectroscopy (DRS), and laser Doppler perfusion measurements (LDPM) to assess the measuring depth of the three techniques and to describe the acute trauma effects on nutritive and thermoregulatory perfusion...
June 20, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28627137/effect-of-sympathetic-nerve-blockade-on-low-frequency-oscillations-of-forearm-and-leg-skin-blood-flow-in-healthy-humans
#3
Gary J Hodges, Matthew M Mallette, Zachary T Martin, Andrew T Del Pozzi
Examine the effect of inhibiting sympathetic function on cutaneous vasomotion in the forearm and leg METHODS: Intradermal microdialysis fibres were placed in the forearm and leg, one as an untreated control (lactated Ringer's) the other perfused with bretylium tosylate to block sympathetic nerves. Skin blood flow was monitored using laser-Doppler flowmetry. Baseline was collected for 10 min before local skin temperature was increased to 42°C. Spectral analysis was performed using a Morlet wavelet RESULTS: Bretylium tosylate increased skin blood flow during baseline in the forearm (d=1...
June 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28627086/the-hypertension-of-hemophilia-is-associated-with-vascular-remodeling-in-the-joint
#4
Richard Fw Barnes, Thomas J Cramer, Tudor H Hughes, Annette von Drygalski
OBJECTIVE: Hemophilic arthropathy is associated with pronounced vascular joint remodeling. Also, compared to the general population, PWH have a higher prevalence of hypertension not explained by usual risk factors. Since vascular remodeling in various vascular beds is a hallmark of hypertension, we hypothesized that vascular joint remodeling is associated with elevated blood pressures and hypertension. METHODS: Elbows, knees and ankles of 28 adult PWH were evaluated for vascular abnormalities with MSKUS/PD, as well as for radiographic and clinical status and pain...
June 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28613418/differences-in-optic-nerve-head-microcirculation-between-evening-and-morning-in-patients-with-coronary-artery-disease
#5
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori
PURPOSE: To determine whether differences or variation of blood flow in the optic nerve head (ONH) are independent risk factors for coronary artery disease (CAD). METHODS: We studied 144 consecutive patients whose ocular blood flow in the ONH was measured in the evening and morning by laser speckle flowgraphy (LSFG). We analysed the mean blur rate (MBR) throughout the ONH (MBR-A) and in the tissue (MBR-T) and vessels (MBR-V) in the ONH. We also evaluated the MBR-T, -V and -A values obtained in the evening and morning and the variation (Δ) between evening and morning values in each group...
June 14, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28597598/rosa-rugosa-flavonoids-alleviate-myocardial-ischemia-reperfusion-injury-in-mice-by-suppressing-jnk-and-p38-mapk
#6
Xuehui Zhang, Yuhui Wang, Wanli Shen, Shangzhi Ma, Wen Chen, Rong Qi
OBJECTIVE: Although Rosa rugosa has been applied for preventing coronary artery disease, the pharmacological mechanism is little explored. In this study, the effects and mechanisms of Rosa rugosa flavonoids (RRF) on myocardial ischemia reperfusion injury (MIRI) were investigated. METHODS: Mice were pretreated by intragastric administration of 600 mg/kg RRF for 7 days. Then MIRI was induced by 45 min coronary artery ligation and 3 h reperfusion. Myocardial infarct size (MIS) and histopathology, activities of myocardial enzymes and effects of RRF on inflammation and apoptosis were evaluated...
June 9, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28585358/muscle-microcirculation-alterations-and-relation-to-dipping-status-in-newly-diagnosed-untreated-patients-with-arterial-hypertension-a-pilot-study
#7
Georgios Tzanis, Stavros Dimopoulos, Chris Manetos, Eleni Koroboki, Efstathios Manios, Ioannis Vasileiadis, Nikolaos Zakopoulos, Serafim Nanas
OBJECTIVE: The importance of abnormalities observed in the microcirculation of patients with arterial hypertension (AH) is being increasingly recognized. The authors aimed to evaluate skeletal muscle microcirculation in untreated, newly diagnosed hypertensive patients with Near Infrared Spectroscopy (NIRS), a non-invasive method that evaluates microcirculation. METHODS: We evaluated 34 subjects, 17 patients with AH (13 males, 49±13y, BMI: 26±2 kg/m(2) ) and 17 healthy controls (12 males, 49±15y, BMI: 25±3 kg/m(2) )...
June 5, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28544033/impaired-neurovascular-reactivity-in-the-microvasculature-of-pregnant-women-with-preeclampsia
#8
Karine Ferreira Agra, Isabelle Eunice Albuquerque Pontes, José Roberto da Silva, José Natal Figueiroa, Geraldine F Clough, João Guilherme Bezerra Alves
Preeclampsia (PE) is associated with maternal vascular dysfunction, leading to serious cardiovascular risk both during and following pregnancy. OBJECTIVE: To assess microvascular reactivity in pregnant women with PE. METHODS: A cross-sectional study was performed in 36 pregnant women with PE and 36 normotensive pregnant women (C) in the third trimester. Skin microvascular blood flow was measured using laser Doppler flowmetry at rest (RF), during the maximum hyperaemic response to brief arterial occlusion (MF) and during the sympathetically-mediated constrictor response to deep inspiratory breath hold (IBH)...
May 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28510992/lymph-node-effective-vascular-permeability-and-chemotherapy-uptake
#9
Eelco Fj Meijer, Cedric Blatter, Ivy X Chen, Echoe Bouta, Dennis Jones, Ethel R Pereira, Keehoon Jung, Benjamin J Vakoc, James W Baish, Timothy P Padera
OBJECTIVE: Lymph node metastases are a poor prognostic factor. Additionally, responses of lymph node metastasis to therapy can be different from the primary tumor. Investigating the physiologic lymph node blood vasculature might give insight into the ability of systemic drugs to penetrate the lymph node, and thus into the differential effect of therapy between lymph node metastasis and primary tumors. Here, we measured effective vascular permeability of lymph node blood vessels and attempted to increase chemotherapy penetration by increasing effective vascular permeability...
May 16, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28510986/blood-pressure-normalization-via-pharmacotherapy-improves-cutaneous-microvascular-function-through-no-dependent-and-independent-mechanisms
#10
Daniel H Craighead, Caroline J Smith, Lacy M Alexander
Hypertension is associated with endothelial dysfunction and vascular remodeling. OBJECTIVE: To assess effects of antihypertensive pharmacotherapy on eNOS and iNOS-dependent mechanisms and maximal vasodilator capacity in the cutaneous microvasculature METHODS: Intradermal microdialysis fibers were placed in 15 normotensive (SBP 111±2 mmHg), 12 unmedicated hypertensive (SBP 142±2 mmHg), and 12 medicated hypertensive (SBP 120±2 mmHg) subjects. Treatments were control, iNOS-inhibited (1400w), and NOS-inhibited (L-NAME)...
May 16, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28480622/roles-of-nadph-oxidase-and-mitochondria-in-flow-induced-vasodilation-of-human-adipose-arterioles-ros-induced-ros-release-in-coronary-artery-disease
#11
Natalya S Zinkevich, Ibra S Fancher, David D Gutterman, Shane A Phillips
OBJECTIVES: Hydrogen peroxide (H2 O2 ) contributes to flow-induced dilation (FID) of human arterioles. This study is designed to examine the roles of mitochondria and NADPH oxidase in modulating the release of ROS and in mediating FID. We tested whether NADPH oxidase contributes to mitochondrial ROS generation in arterioles during coronary artery disease (CAD). METHODS: Visceral adipose arterioles obtained from patients with or without CAD were cannulated and pressurized for videomicroscopic measurement of arteriolar diameters...
May 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28477419/the-impact-of-endotoxin-on-jejunal-tissue-oxygenation
#12
Werner Pajk, Karl-Heinz Stadlbauer, Axel Kleinsasser, Oskar Kotzinger, Hanno Ulmer, Walter Hasibeder, Hans Knotzer
OBJECTIVE: We examined the effects of systemic endotoxin on jejunal mucoal microcirculatory parameters in anesthetized pigs. MATERIALS AND METHODS: Jejunal mucosal tissue PO2 was measured employing Clark-type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated...
May 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28470950/microfluidic-technologies-and-approaches-for-studying-the-microcirculation
#13
Walter L Murfee, Shayn M Peirce
A challenge for basic and applied microvascular research is the lack of ex vivo experimental platforms that mimic the structural and functional complexity that is inherent to the microcirculation in living organisms. This Special Topic Issue highlights the emergence of microfluidic based approaches as tools for recapitulating physiologically-relevant network architectures and hemodynamics in order to study biochemical and biomechanical mechanisms of microvascular function and adaptation. This collection of review and original research articles showcases the value of microfluidics in bridging the gap between in vivo and in vitro model systems by demonstrating the utility of this technology for investigating microvascular dynamics spanning angiogenesis to blood cell rheology and for pre-clinical evaluation of therapeutic strategies that target the microcirculation...
May 4, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28470885/estimating-blood-flow-in-skeletal-muscle-arteriolar-trees-reconstructed-from-in-vivo-data-using-the-fry-approach
#14
Zahra Farid, Amani H Saleem, Baraa K Al-Khazraji, Dwayne N Jackson, Daniel Goldman
OBJECTIVE: To develop a computational method to accurately predict blood flow in skeletal muscle arteriolar trees in the absence of complete boundary data. METHODS: We used arteriolar trees in the rat GM muscle that were reconstructed from montages obtained via IVVM, and incorporated a recently published method for approximating unknown boundary conditions into our existing two-phase, steady-state blood flow model. For varying numbers of unknown boundary conditions, we used the new flow model and GM geometry to approximately match RBC flows corresponding to experimental measurements...
May 4, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28387057/hypoxia-enhanced-adhesion-of-red-blood-cells-in-microscale-flow
#15
Myeongseop Kim, Yunus Alapan, Anima Adhikari, Jane A Little, Umut A Gurkan
OBJECTIVES: The advancement of microfluidic technology has facilitated the simulation of physiological conditions of the microcirculation, such as oxygen tension, fluid flow, and shear stress in these devices. Here, we present a micro-gas exchanger integrated with microfluidics to study RBC adhesion under hypoxic flow conditions mimicking postcapillary venules. METHODS: We simulated a range of physiological conditions and explored RBC adhesion to endothelial or subendothelial components (FN or LN)...
July 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28376260/cdc42-regulates-branching-in-angiogenic-sprouting-in-vitro
#16
Duc-Huy T Nguyen, Lin Gao, Alec Wong, Christopher S Chen
OBJECTIVES: The morphogenetic events that occur during angiogenic sprouting involve several members of the Rho family of GTPases, including Cdc42. However, the precise roles of Cdc42 in angiogenic sprouting have been difficult to elucidate owing to the lack of models to study these events in vitro. Here, we aim to identify the roles of Cdc42 in branching morphogenesis in angiogenesis. METHODS: Using a 3D biomimetic model of angiogenesis in vitro, where endothelial cells were seeded inside a cylindrical channel within collagen gel and sprouted from the channel in response to a defined biochemical gradient of angiogenic factors, we inhibited Cdc42 activity with a small molecule inhibitor ML141 and examined the effects of Cdc42 on the morphogenetic processes of angiogenic sprouting...
July 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28129479/a-microfluidic-platform-to-study-the-effects-of-vascular-architecture-and-oxygen-gradients-on-sickle-blood-flow
#17
REVIEW
Xinran Lu, Michelle M Galarneau, John M Higgins, David K Wood
Our goal was to develop a model of the microvasculature that would allow us to quantify changes in the rheology of sickle blood as it traverses the varying vessel sizes and oxygen tensions in the microcirculation. We designed and implemented a microfluidic model of the microcirculation that comprises a branching microvascular network and physiologic oxygen gradients. We used computational modeling to determine the parameters necessary to generate stable, linear gradients in our devices. Sickle blood from six unique patients was perfused through the microvascular network and subjected to varying oxygen gradients while we observed and quantified blood flow...
July 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27647727/influence-of-red-blood-cell-aggregation-on-perfusion-of-an-artificial-microvascular-network
#18
Walter H Reinhart, Nathaniel Z Piety, Sergey S Shevkoplyas
OBJECTIVE: RBCs suspended in plasma form multicellular aggregates under low-flow conditions, increasing apparent blood viscosity at low shear rates. It has previously been unclear, however, if RBC aggregation affects microvascular perfusion. Here, we analyzed the impact of RBC aggregation on perfusion and 'capillary' hematocrit in an AMVN at driving pressures ranging from 5 to 60 cm H2 O to determine if aggregation could improve tissue oxygenation. METHODS: RBCs were suspended at 30% hematocrit in either 46...
July 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28504408/kv1-3-channels-facilitate-the-connection-between-metabolism-and-blood-flow-in-the-heart
#19
REVIEW
Vahagn Ohanyan, Liya Yin, Raffi Bardakjian, Christopher Kolz, Molly Enrick, Tatevik Hakobyan, Jordan Luli, Kathleen Graham, Mohamed Khayata, Suzanna Logan, John Kmetz, William M Chilian
The connection between metabolism and flow in the heart, metabolic dilation, is essential for cardiac function. We recently found redox-sensitive Kv1.5 channels play a role in coronary metabolic dilation; however, more than one ion channel likely plays a role in this process as animals null for these channels still showed limited coronary metabolic dilation. Accordingly, we examined the role of another Kv1 family channel, the energetically linked Kv1.3 channel, in coronary metabolic dilation. We measured myocardial blood flow (contrast echocardiography) during norepinephrine-induced increases in cardiac work (heart rate x mean arterial pressure) in WT, WT mice given correolide (preferential Kv1...
May 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28071840/%C3%AE-adrenergic-blockade-does-not-impair-the-skin-blood-flow-sensitivity-to-local-heating-in-burned-and-nonburned-skin-under-neutral-and-hot-environments-in-children
#20
Eric Rivas, Serina J McEntire, David N Herndon, Ronald P Mlcak, Oscar E Suman
OBJECTIVE: We tested the hypothesis that propranolol, a drug given to burn patients to reduce hypermetabolism/cardiac stress, may inhibit heat dissipation by changing the sensitivity of skin blood flow (SkBF) to local heating under neutral and hot conditions. METHODS: In a randomized double-blind study, a placebo was given to eight burned children, while propranolol was given to 13 burned children with similar characteristics (mean±SD: 11.9±3 years, 147±20 cm, 45±23 kg, 56±12% Total body surface area burned)...
May 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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