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Filippo Ceccato, Marialuisa Zilio, Mattia Barbot, Nora Albiger, Giorgia Antonelli, Mario Plebani, Sara Watutantrige-Fernando, Chiara Sabbadin, Marco Boscaro, Carla Scaroni
INTRODUCTION AND AIM: Medical treatment is increasingly used in patients with Cushing's syndrome (CS). Metyrapone (MET) is an inhibitor of 11β-hydroxylase: retrospective studies reported a decrease of cortisol secretion in 50% of cases. We evaluated the effectiveness of MET in an observational study, considering the normalization of urinary-free cortisol (UFC) and late-night salivary cortisol (LNSC) levels. MATERIALS AND METHODS: We enrolled 31 patients with CS, treated with MET for at least 1 month (16 for primary treatment and 15 after surgical failure)...
July 16, 2018: Endocrine
María Luisa De Mingo Dominguez, Sonsoles Guadalix Iglesias, Cristina Martín-Arriscado Arroba, Begoña López Álvarez, Guillermo Martínez Diaz-Guerra, José Ignacio Martinez-Pueyo, Eduardo Ferrero Herrero, Federico Hawkins Carranza
The effect of thyroid suppression therapy (TST) on trabecular bone scores (TBS) and bone mineral density (BMD) in thyroidectomized women with differentiated thyroid carcinoma (DTC) on long-term follow-up is presently not conclusive. PATIENTS AND METHODS: We carried out a study in 61 premenopausal and 84 postmenopausal Caucasian women with DTC. Serum biochemistry, bone markers, TBS, BMD, and bone fractures were evaluated 1-3 months post surgery and after a median follow-up of 10 years...
July 16, 2018: Endocrine
Miao Liu, Ru Tang, Jianhua Wang, Yao He
AIMS: To describe the distribution and changes of different metabolic/obese phenotypes among more than 22,000 male elderly in China, and also explore the association with diabetes incidence. METHODS: A cohort study based on 22,276 male elderly was conducted in Beijing, from 2009 to 2013. Multiple Cox model was used to calculate the relative risk. RESULTS: There were only 53.8% of total participants who kept the same phenotype for the 5 years...
July 13, 2018: Endocrine
Domenico Meringolo, Irene Campi, Giuseppe Costante
No abstract text is available yet for this article.
July 9, 2018: Endocrine
Rosita A Condorelli, Rossella Cannarella, Aldo E Calogero, Sandro La Vignera
INTRODUCTION: The assessment of testicular function is not currently performed in childhood. The aim of this review was to address the usefulness of serum Anti-Müllerian Hormone (AMH), inhibin B, and testicular volume (TV) evaluation in children. REVIEW: Serum AMH and inhibin B levels reflect Sertoli cells (SCs) health and number, SCs maturation degree and their exposure to FSH and to intra-tubular testosterone (T). These hormones might be helpful in discriminating between congenital central hypogonadism (cHH) and constitutional delay in growth and puberty (CDGP) and in case of clinical suspicious of precocious puberty...
July 7, 2018: Endocrine
Mattia Barbot, Valentina Guarnotta, Marialuisa Zilio, Filippo Ceccato, Alessandro Ciresi, Andrea Daniele, Giuseppe Pizzolanti, Elena Campello, Anna Chiara Frigo, Carla Giordano, Carla Scaroni
INTRODUCTION: Cushing's disease (CD) is characterized by procoagulative profile. Treatment with cortisol-reducing medications might normalize the coagulation impairment potentially eliminating the risk of thromboembolic complications. AIM: The aim of this prospective study is to evaluate the effectiveness of 6-12 months of treatment with pasireotide (Signifor®, Novartis) 600 µg twice daily on coagulative factors in 21 patients (16 females, mean age 46 ± 12...
July 6, 2018: Endocrine
Christos Karefylakis, Stefan Särnblad, Annaclara Ariander, Gustaf Ehlersson, Eva Rask, Peter Rask
PURPOSE: Several observational studies have shown an association between vitamin D deficiency and non-skeletal major health issues including impaired cardiorespiratory fitness and adiposity. Only a few studies have examined the impact of vitamin D supplementation on these conditions and the results are ambiguous. The aim of this study was to examine the effect of vitamin D supplementation on body composition and cardiorespiratory fitness in overweight/obese men with vitamin D deficiency...
July 5, 2018: Endocrine
Pedro Weslley Rosario, Grabriela Franco Mourão
No abstract text is available yet for this article.
July 4, 2018: Endocrine
Graziano Grugni, Antonino Crinò, Annamaria De Bellis, Alessio Convertino, Sarah Bocchini, Sabrina Maestrini, Paolo Cirillo, Silvana De Lucia, Maurizio Delvecchio
The role of antipituitary antibodies in the pathophysiology of pituitary hormone deficiency has been increasingly elucidated over the last decade. Prader-Willi syndrome is a genetic disorder which includes hypothalamic/pituitary dysfunction as one of its main features. We looked for autoimmune pituitary involvement in 55 adults with Prader-Willi syndrome, discovering that about 30% of them have a positive titer of antipituitary antibodies. Although the presence of these autoantibodies could only be an "epiphenomenon", our results suggest that autoimmune mechanisms might contribute, at least in part, to the pituitary impairment of Prader-Willi syndrome, and in addition to genetically determined dysfunction of the central nervous system...
July 2, 2018: Endocrine
Ludovico Maria Garau, Domenico Rubello, Alice Ferretti, Giuseppe Boni, Duccio Volterrani, Gianpiero Manca
PURPOSE: Sentinel lymph node biopsy (SNB) in patients with papillary thyroid carcinoma (PTC) and negative for clinically neck lymph node metastatic involvement (N0) has emerged as a promising minimally invasive procedure to detect metastatic nodes. METHODS: The MEDLINE database was searched via the PubMed interface on 10 January 2018 for the MeSH headings "sentinel lymph node biopsy" and "thyroid carcinoma". RESULTS: Vital blue dye, radioisotope, and the combination of both techniques are used in PTC patients...
July 2, 2018: Endocrine
Henrik Borg, Peter Siesjö, Babar Kahlon, Sigridur Fjalldal, Eva Marie Erfurth
PURPOSE: No previous study has analyzed serum cortisol levels during transsphenoidal endoscopic pituitary surgery in patients with and without hydrocortisone (HC) substitution. METHODS: A total of 15 patients undergoing surgery for a pituitary adenoma were studied. Those with normal ACTH function were either not given HC (n = 7) or received 50 mg intravenous HC at the start of surgery (n = 4). Patients with ACTH deficiency received intravenous HC of 100 mg in the morning before surgery (n = 4) with the additional 50 mg for an afternoon operation (n = 2)...
July 2, 2018: Endocrine
Ilgin Yildirim Simsir, Murat Ozdemir, Soner Duman, Mehmet Erdogan, Ayhan Donmez, Ahmet Gokhan Ozgen
PURPOSE: For the treatment of thyrotoxicosis, alternative treatment modalities may be necessary if anti-thyroid drugs cannot be used due to side effects, inefficiencies, or there is a need to start a rapid action such as thyroid storm. By using therapeutic plasma exchange (TPE), it is possible to effectively and rapidly remove the increased thyroid hormones. We evaluated our results and experience on a rapid, effective, and reliable alternative treatment modality in thyrotoxic patients...
July 2, 2018: Endocrine
Kelsi E Deaver, Colin P Catel, Kevin O Lillehei, Margaret E Wierman, Janice M Kerr
PURPOSE: Disorders of water balance, particularly hyponatremia from altered antidiuretic hormone (ADH) secretion, are a common post-operative complication of transsphenoidal surgery (TSS). We present our results from implementation of a 2-week 1.5 liter/daily fluid restriction on readmission rates for hyponatremia. METHODS: A retrospective chart review was performed on 295 patients that underwent TSS for pituitary adenomas at the University of Colorado, between March 2014 and March 2017...
June 30, 2018: Endocrine
Marina Djurovic, Alberto M Pereira, Johannes W A Smit, Olga Vasovic, Svetozar Damjanovic, Zvezdana Jemuovic, Dragan Pavlovic, Dragana Miljic, Sandra Pekic, Marko Stojanovic, Milika Asanin, Gordana Krljanac, Milan Petakov
OBJECTIVE: Intrinsic imperfections of thyroid hormone replacement therapy may affect long-term general well-being. In patients with Hashimoto thyroiditis (HT), cognitive functioning may be affected via altered thyroid hormones action as well as by the autoimmune process. The aim of this study was to evaluate cognitive function and quality of life (QoL) in patients on long-term levothyroxine replacement for HT in relation to thyroid function tests and TPO (thyroid-peroxidase) antibody (TPOAb) status...
June 29, 2018: Endocrine
Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Qing Zhu, Jin-Ling Ren, Yan-Rong Yu, Xiu-Ying Liu, Xiu-Jie Wang, Mei Han, Qing Jing, Jie Du, Chao-Shu Tang, Yong-Fen Qi
Endoplasmic reticulum stress (ERS) is involved in the development of abdominal aortic aneurysm (AAA). Since bioactive peptide intermedin (IMD)1-53 protects against AAA formation, here we investigated whether IMD1-53 attenuates AAA by inhibiting ERS. AAA model was induced by angiotensin II (AngII) in ApoE KO mouse background. AngII-treated mouse aortas showed increased ERS gene transcription of caspase12, eukaryotic translation initiation factor 2a (eIf2a) and activating transcription factor 4(ATF4).The protein level of ERS marker glucose regulated protein 94(GRP94), ATF4 and C/EBP homologous protein 10(CHOP) was also up-regulated by AngII...
June 26, 2018: Endocrine
Zihao Wang, Bing Xing
No abstract text is available yet for this article.
June 25, 2018: Endocrine
Susan M Webb
No abstract text is available yet for this article.
June 22, 2018: Endocrine
Na Yi, Lijin Ji, Qi Zhang, Shuo Zhang, Xiaoxia Liu, Xuefei Shou, Bin Lu
CONTEXT: Prolactinoma is the most common subtype of functional pituitary adenoma. Effective therapy is required for women of child-bearing age to achieve remission at serum prolactin level and regain reproductive function. PURPOSE: To evaluate long-term outcomes, including menstrual recovery, after transsphenoidal surgery on female prolactinoma patients by experienced neurosurgeons. DESIGN: Observational study. PATIENTS: Consecutive female prolactinoma patients aged from 16 to 45 years were included...
June 22, 2018: Endocrine
Xiaopeng Guo, Yumo Zhao, Man Wang, Lu Gao, Zihao Wang, Zhuhua Zhang, Bing Xing
PURPOSE: To evaluate the incidence of obstructive sleep apnea-hypopnea syndrome (OSAHS), explore the structural changes in pharyngeal soft tissue underlying OSAHS development and analyze the correlation between hormone levels and pharyngeal soft tissue changes in patients with untreated acromegaly. METHODS: Twenty-five patients with untreated acromegaly were prospectively enrolled. Pituitary hormones were tested, sellar magnetic resonance imaging was confirmed, overnight polysomnography was conducted, and upper airway computed tomography was performed on these patients...
June 21, 2018: Endocrine
G Montalbano, M Mania, F Abbate, M Navarra, M C Guerrera, R Laura, J A Vega, M Levanti, A Germanà
PURPOSE: Overweight and obesity are important risk factors for diabetes, cardiovascular diseases, and premature death in modern society. Recently, numerous natural and synthetic compounds have been tested in diet-induced obese animal models, to counteract obesity. Melatonin is a circadian hormone, produced by pineal gland and extra-pineal sources, involved in processes which have in common a rhythmic expression. In teleost, it can control energy balance by activating or inhibiting appetite-related peptides...
June 20, 2018: Endocrine
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