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Endocrine

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https://www.readbyqxmd.com/read/28337657/hypovitaminosis-d-in-patients-with-heart-failure-effects-on-functional-capacity-and-patients-survival
#1
Federica Saponaro, Claudio Marcocci, Riccardo Zucchi, Concetta Prontera, Aldo Clerico, Marco Scalese, Sabina Frascarelli, Alessandro Saba, Claudio Passino
Chronic heart failure is a major cause of morbidity and mortality, but its prognosis remains poor. Vitamin D hormone has many extra-skeletal functions including a positive impact on the cardiovascular system, and has been proposed for mortality risk evaluation in heart failure patients. The aim of the present study was to evaluate vitamin D status in heart failure patients, measured by high performance liquid chromatography coupled with mass spectrometry and to correlate serum 25 hydroxy-vitamin D (25OHD) levels with functional (peak VO2%) and mortality (Metabolic Exercise Cardiac Kidney Index) heart failure parameters...
March 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28332074/matrix-metalloproteinase-2-mmp-2-levels-are-increased-in-active-acromegaly-patients
#2
Alper Cagri Karci, Zeynep Canturk, Ilhan Tarkun, Berrin Cetinarslan
PURPOSE: During follow-up of acromegaly patients, there is a discordance rate of 30% between the measurements of growth hormone and insulin-like growth factor-1 levels. Further tests are required to determine disease activity in patients with discordant results. This study was planned to investigate an association of serum levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and cathepsin B with disease activity in acromegaly patients. METHODS: In this study, 64 acromegaly patients followed in our clinic were divided into two groups according to the 2010 consensus criteria for cure of acromegaly as patients with active disease (n = 24) and patients with controlled disease (n = 40)...
March 22, 2017: Endocrine
https://www.readbyqxmd.com/read/28303515/pasireotide-versus-pituitary-surgery-a-retrospective-analysis-of-12-months-of-treatment-in-patients-with-cushing-s-disease
#3
LETTER
Valentina Guarnotta, Alessandro Ciresi, Maria Pitrone, Giuseppe Pizzolanti, Carla Giordano
No abstract text is available yet for this article.
March 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28303514/euglycemic-ketosis-in-patients-with-type-2-diabetes-on-sglt2-inhibitor-therapy-an-emerging-problem-and-solutions-offered-by-diabetes-technology
#4
A Pfützner, D Klonoff, L Heinemann, N Ejskjaer, J Pickup
Diabetic ketoacidosis is an infrequent but life-threatening acute complication of diabetes, affecting predominantly patients with type 1 diabetes, children, and pregnant women, where ketosis is usually associated with marked hyperglycemia. Recently, an increasing number of cases have been reported of euglycemic diabetic ketoacidosis in patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitor treatment in routine practice. There is a minor, but not negligible diabetic ketoacidosis risk associated with this drug class, which was not seen in randomized clinical trials...
March 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28303513/increased-incidence-trend-of-low-grade-and-high-grade-neuroendocrine-neoplasms
#5
Emanuele Leoncini, Paolo Boffetta, Michail Shafir, Katina Aleksovska, Stefania Boccia, Guido Rindi
PURPOSE: The incidence of neuroendocrine neoplasms is increasing. This work aimed at: (i) establishing worldwide incidence trend of low-grade neuroendocrine neoplasms; (ii) defining the incidence and temporal trend of high-grade neuroendocrine neoplasms in USA utilizing the Surveillance Epidemiology and End Results database; (iii) comparing trends for low-grade vs. high-grade neuroendocrine neoplasms. METHODS: We conducted a literature search on MEDLINE and Scopus databases and incidence trends were plotted for 1973-2012...
March 16, 2017: Endocrine
https://www.readbyqxmd.com/read/28299573/mkrn3-levels-in-girls-with-central-precocious-puberty-and-correlation-with-sexual-hormone-levels-a-pilot-study
#6
Anna Grandone, Grazia Cirillo, Marcella Sasso, Carlo Capristo, Gianluca Tornese, Pierluigi Marzuillo, Caterina Luongo, Giuseppina Rosaria Umano, Adalgisa Festa, Ruggero Coppola, Emanuele Miraglia Del Giudice, Laura Perrone
PURPOSE: Recently, mutations of makorin RING-finger protein 3 (MKRN3) have been described in familial central precocious puberty. Serum levels of this protein decline before the pubertal onset in healthy girls and boys. The aim of the study is to investigate MKRN3 circulating levels in patients with central precocious puberty. METHODS: We performed an observational cross-sectional study. We enrolled 17 patients with central precocious puberty aged 7 years (range: 2-8 years) and breast development onset <8 years; 17 prepubertal control age-matched patients aged 6...
March 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28293857/effect-of-cilostazol-in-treating-diabetes-associated-microvascular-complications
#7
REVIEW
Nicole J Asal, Karolina A Wojciak
PURPOSE: Cilostazol (Pletal), a phosphodiesterase-3 inhibitor, was approved in the United States in 1999 to reduce symptoms of intermittent claudication. Cyclic adenosine monophosphate levels increase from inhibition of phosphodiesterase resulting in anti-platelet, anti-inflammatory, and vasodilatory effects. Diabetes mellitus is a chronic disease that causes endothelial and platelet dysfunction leading to both microvascular and macrovascular complications. This mini-review highlights the emerging evidence suggesting benefits of using cilostazol in treating microvascular complications associated with diabetes mellitus...
March 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28293856/imaging-of-diabetic-bone
#8
Federico Ponti, Sara Guerri, Claudia Sassi, Giuseppe Battista, Giuseppe Guglielmi, Alberto Bazzocchi
Diabetes is an important concern in terms of medical and socioeconomic costs; a high risk for low-trauma fractures has been reported in patients with both type 1 and type 2 diabetes. The mechanism involved in the increased fracture risk from diabetes is highly complex and still not entirely understood; obesity could play an important role: recent evidence suggests that the influence of fat on bone is mainly dependent on the pattern of regional fat deposition and that an increased amount of visceral adipose tissue negatively affects skeletal health...
March 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28285385/real-time-elastography-in-autonomously-functioning-thyroid-nodules-relationship-with-tsh-levels-scintigraphy-and-ultrasound-patterns
#9
Pierpaolo Trimboli, Gaetano Paone, Maria Chiara Zatelli, Luca Ceriani, Luca Giovanella
BACKGROUND: Real-time elastography has been proposed to increase the sensitivity of ultrasound and improve the detection of thyroid nodules at risk of malignancy. To date sparse data on real-time elastography assessment of autonomously functioning thyroid nodules exist. Here, we investigated the potential role of real-time elastography in autonomously functioning thyroid nodule assessment. Specifically, the correlation between serum hormones and real-time elastography score, as well as other clinical and ultrasound features, was analyzed...
March 11, 2017: Endocrine
https://www.readbyqxmd.com/read/28285384/growth-hormone-and-cortisol-secretion-in-the-elderly-evaluated-using-the-glucagon-stimulation-test
#10
Ana Beatriz Winter Tavares, Ignácio Antônio Seixas-da-Silva, Diego H S Silvestre, Maria Fernanda Castelar Pinheiro, Mario Vaisman, Flávia Lucia Conceição
OBJECTIVES: The glucagon stimulation test is a reliable alternative test to assess growth hormone and cortisol secretion, but has not been widely used in the elderly population. The aim of this study was to evaluate growth hormone and cortisol secretion using the glucagon stimulation test in an elderly population without known hypothalamic-pituitary disease and to correlate growth hormone and cortisol peaks with age (less than or greater than 80 years) and body mass index. METHODS: Forty-two subjects (67-88 years) from the geriatric ambulatory unit were submitted and 41 subjects completed the glucagon stimulation test...
March 11, 2017: Endocrine
https://www.readbyqxmd.com/read/28283939/high-dose-of-radioactive-iodine-per-se-has-no-effect-on-glucose-metabolism-in-thyroidectomized-rats
#11
Roghaieh Samadi, Mahboubeh Ghanbari, Babak Shafiei, Sevda Gheibi, Fereidoun Azizi, Asghar Ghasemi
PURPOSE: Thyroid concentrates radioactive iodine by sodium-iodide symporter; this is used for treating hyperthyroidism and thyroid cancer. Pancreas expresses NIS and radioactive iodine uptake may damage pancreatic beta-cells and predispose patients to type 2 diabetes. The aim of this study was to determine whether radioactive iodine is associated with glucose metabolism in thyroidectomized rats. METHODS: Forty male Wistar rats were divided into four groups (n = 10/each); control, thyroidectomized, thyroidectomized-treated with 131-I (TX+I), and thyroidectomized-treated with 131-I and L-thyroxine (TX+I+T4)...
March 10, 2017: Endocrine
https://www.readbyqxmd.com/read/28271396/intestinal-absorption-and-buccal-absorption-of-liquid-levothyroxine
#12
LETTER
Salvatore Benvenga, Flavia Di Bari
No abstract text is available yet for this article.
March 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28271395/comparing-pre-therapeutic-124-i-and-131-i-uptake-tests-with-intra-therapeutic-131-i-uptake-in-benign-thyroid-disorders
#13
Falk Gühne, Christian Kühnel, Martin Freesmeyer
PURPOSE: (124)I-PET/CT can be used for pre-therapeutic assessment of radioactive iodine uptake in benign thyroid disorders, however systematic comparisons with intra-therapeutic uptake are still lacking for these disorders. The goals of this study were to compare (124)I RAIU and conventional (131)I RAIU tests with each other; to compare both tests with intra-therapeutic uptake (reference); and to verify the time course of radioactive iodine uptake at three time points (30, 102, and 336 h [14 days] post administration; p...
March 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28265858/palbociclib-inhibits-proliferation-of-human-adrenocortical-tumor-cells
#14
LETTER
Chiara Fiorentini, Martina Fragni, Guido A M Tiberio, Diego Galli, Elisa Roca, Valentina Salvi, Daniela Bosisio, Cristina Missale, Massimo Terzolo, Maurizio Memo, Alfredo Berruti, Sandra Sigala
No abstract text is available yet for this article.
March 6, 2017: Endocrine
https://www.readbyqxmd.com/read/28260207/biochemical-assessment-of-disease-control-in-acromegaly-reappraisal-of-the-glucose-suppression-test-in-somatostatin-analogue-sa-treated-patients
#15
Mai Christiansen Arlien-Søborg, Christian Trolle, Elin Alvarson, Amanda Bæk, Jakob Dal, Jens Otto Lunde Jørgensen
BACKGROUND: It is recommended not to measure growth hormone during oral glucose suppression (oral glucose tolerance test) during somatostatin analog treatment in acromegaly. However, we have observed that failure to suppress growth hormone in response to oral glucose tolerance test during somatostatin analog unmasks insufficient disease control and hypothesize that somatostatin analog also induces insufficient growth hormone suppression to mixed meals. METHODS: We therefore compared serum growth hormone levels during two mixed meals in patients with controlled insulin-like growth factor-I levels after either surgery alone (n = 9) or somatostatin analog treatment (n = 9)...
March 4, 2017: Endocrine
https://www.readbyqxmd.com/read/28260206/follicle-stimulating-hormone-its-novel-association-with-sex-hormone-binding-globulin-in-men-and-postmenopausal-women
#16
Ningjian Wang, Kun Zhang, Bing Han, Qin Li, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Hualing Zhai, Boren Jiang, Zhoujun Shen, Yingli Lu
PURPOSE: Follicle stimulating hormone plays direct roles in a variety of nongonadal tissues and sex hormone binding globulin is becoming the convergence of the crosstalk among metabolic diseases. However, no studies have explored the association between follicle stimulating hormone and sex hormone binding globulin. We aimed to study this association among men and women. METHODS: SPECT-China is a population-based study conducted since 2014. This study included 4206 men and 2842 postmenopausal women...
March 4, 2017: Endocrine
https://www.readbyqxmd.com/read/28260205/cabergoline-for-hyperprolactinemia-getting-to-the-heart-of-it
#17
EDITORIAL
Lisa B Nachtigall
No abstract text is available yet for this article.
March 4, 2017: Endocrine
https://www.readbyqxmd.com/read/28247312/interference-in-acth-immunoassay-negatively-impacts-the-management-of-subclinical-hypercortisolism
#18
Serkan Yener, Leyla Demir, Mustafa Demirpence, Mustafa Mahmut Baris, Ilgin Yildirim Simsir, Secil Ozisik, Abdurrahman Comlekci, Tevfik Demir
PURPOSE: Low plasma corticotropin is considered a useful parameter for the diagnosis of subclinical hypercortisolism in patients with an adrenal incidentaloma. However, immunoassays are vulnerable to interference from endogenous antibodies. In this study, subjects who underwent Hypothalamus-pituitary-adrenal axis evaluation for the assessment of subclinical hypercortisolism were evaluated. The objective of the study was to ascertain whether antibody interference in corticotropin immunoassay affected the diagnostic work-up and clinical decisions...
February 28, 2017: Endocrine
https://www.readbyqxmd.com/read/28243973/presence-of-headache-and-headache-types-in-patients-with-tumors-of-the-sellar-region-can-surgery-solve-the-problem-results-of-a-prospective-single-center-study
#19
Sonja Siegel, Renata Weber Carneiro, Michael Buchfelder, Bernadette Kleist, Agnieszka Grzywotz, Rolf Buslei, Ulrike Bingel, Georg Brabant, Thomas Schenk, Ilonka Kreitschmann-Andermahr
PURPOSE: Headache is a common presenting feature of patients with pituitary adenomas and other tumors of the sellar region. However, at present, it still is unclear whether the headache is actually caused by the tumor. To explore whether there is a relation, we examined in detail the headache types, their relationship to the underlying pathology, and if the headache responded to neurosurgery in a prospective study design. METHODS: One hundred twelve patients with tumors of the sellar region scheduled for neurosurgery in a single center were analyzed for presence and quality of headache before surgery and at least 3 months after surgery...
February 27, 2017: Endocrine
https://www.readbyqxmd.com/read/28243972/genetic-interaction-of-dgat2-and-faah-in-the-development-of-human-obesity
#20
Tinglu Ning, Yaoyu Zou, Minglan Yang, Qianqian Lu, Maopei Chen, Wen Liu, Shaoqian Zhao, Yingkai Sun, Juan Shi, Qinyun Ma, Jie Hong, Ruixin Liu, Jiqiu Wang, Guang Ning
PURPOSE: DGAT2 is the critical catalyzing enzyme for triglyceride biosynthesis, and excess triglyceride accumulation in fat tissues is a fundamental process for obesity. Mutations in DGAT2 or other genes interacting with DGAT2 associated with adiposity have not been reported in human to date. METHODS: DGAT2 mutation was identified based on our in-home database-exome sequencing 227 young obese subjects (body-mass index (BMI), 35.1-61.7 kg/m(2)) and 219 lean controls (BMI, 17...
February 27, 2017: Endocrine
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