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Endocrine

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https://www.readbyqxmd.com/read/28730419/the-intriguing-connections-of-leptin-to-hyperparathyroidism
#1
REVIEW
Stergios A Polyzos, Leonidas Duntas, Jens Bollerslev
PURPOSE: Leptin has been implicated in bone metabolism, but the association with parathyroid gland function has not been fully clarified. This review aimed to summarize evidence of the association between leptin and hyperparathyroidism, both primary and secondary, elucidating the potential pathophysiologic and therapeutic consequences between leptin and parathyroid hormone, hopefully prompting the design of new studies. RESULTS: Experimental studies indicate a positive loop between leptin and parathyroid hormone in primary hyperparathyroidism...
July 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28730418/total-and-free-cortisol-levels-during-1-%C3%AE-g-25-%C3%AE-g-and-250-%C3%AE-g-cosyntropin-stimulation-tests-compared-to-insulin-tolerance-test-results-of-a-randomized-prospective-pilot-study
#2
Seenia Peechakara, James Bena, Nigel J Clarke, Michael J McPhaul, Richard E Reitz, Robert J Weil, Pablo Recinos, Laurence Kennedy, Amir H Hamrahian
PURPOSE: The appropriate cosyntropin dose during cosyntropin stimulation tests remains uncertain. We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency. Insulin tolerance test was used as the gold standard. METHOD: The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12)...
July 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28726185/raising-awareness-on-the-therapeutic-role-of-cholecalciferol-in-ckd-a-multidisciplinary-based-opinion
#3
REVIEW
Sandro Giannini, Sandro Mazzaferro, Salvatore Minisola, Luca De Nicola, Maurizio Rossini, Mario Cozzolino
Vitamin D is recognized to play an essential role in health and disease. In kidney disease, vitamin D analogs have gained recognition for their involvement and potential therapeutic importance. Nephrologists are aware of the use of oral native vitamin D supplementation, however, uncertainty still exists with regard to the use of this treatment option in chronic kidney disease as well as clinical settings related to chronic kidney disease, where vitamin D supplementation may be an appropriate therapeutic choice...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28726184/hormetic-effect-of-triiodothyronine-in-metabolically-healthy-obese-persons
#4
Ji Eun Jun, Tae Hyuk Kim, Seung-Eun Lee, You-Bin Lee, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Yong-Ki Min, Moon-Kyu Lee
PURPOSE: Metabolically healthy obese is the designation for a subgroup of obese individuals with normal metabolic features. However, metabolically healthy obese individuals are prone to developing metabolic syndrome. Serum triiodothyronine (T3) levels are associated with various metabolic risk factors including obesity. Therefore, this longitudinal study aimed to explore the possible correlation between serum T3 concentration and the onset of MetS in metabolically healthy obese persons...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28726183/escalated-dose-somatostatin-analogues-for-antiproliferative-effect-in-gepnets-a-systematic-review
#5
REVIEW
David L Chan, Diego Ferone, Manuela Albertelli, Nick Pavlakis, Eva Segelov, Simron Singh
BACKGROUND/PURPOSE: Somatostatin analogues are the cornerstone of systemic therapy for metastatic well-differentiated gastroenteropancreatic neuroendocrine tumours for both hormonal control and antiproliferative effect. Dose escalation of somatostatin analogues is often utilized in clinical practice, but small studies have yielded mixed results. The aim of this study was to systematically determine the efficacy and safety of escalated-dose somatostatin analogues in the above setting. METHODS: Eligible trials (using more than 30 mg octreotide or 120 mg lanreotide/28 days) were identified from MEDLINE, EMBASE, other databases and conference proceedings...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28726182/autoimmune-hypothyroidism-is-three-times-more-frequent-in-female-prolactinoma-patients-compared-to-healthy-women-data-from-a-cross-sectional-case-control-study
#6
Atanaska Elenkova, Iliana Аtanasova, Georgi Кirilov, Еmil Natchev, Ralitza Ivanova, Roussanka Кovatcheva, Silvia Vandeva, Dimitar Tcharaktchiev, Sabina Zacharieva
BACKGROUND: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population. PURPOSE: A cross-sectional case-control study was carried out in a single tertiary referral centre. The main aim was to assess the frequency of newly diagnosed autoimmune thyroid diseases in female patients with prolactinomas...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28726181/ki-67-heterogeneity-in-well-differentiated-gastro-entero-pancreatic-neuroendocrine-tumors-when-is-biopsy-reliable-for-grade-assessment
#7
Grillo Federica, Valle Luca, Ferone Diego, Albertelli Manuela, Brisigotti Maria Pia, Cittadini Giuseppe, Vanoli Alessandro, Fiocca Roberto, Mastracci Luca
PURPOSE: Ki-67 heterogeneity can impact on gastroenteropancreatic neuroendocrine tumor grade assignment, especially when tissue is scarce. This work is aimed at devising adequacy criteria for grade assessment in biopsy specimens. METHOD: To analyze the impact of biopsy size on reliability, 360 virtual biopsies of different thickness and lengths were constructed. Furthermore, to estimate the mean amount of non-neoplastic tissue component present in biopsies, 28 real biopsies were collected, the non-neoplastic components (fibrosis and inflammation) quantified and the effective area of neoplastic tissue calculated for each biopsy...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28702889/treatment-of-refractory-and-severe-hypothyroidism-with-sublingual-levothyroxine-in-liquid-formulation
#8
LETTER
Carmela Peirce, Serena Ippolito, Alejandra Lanas, Marcella Pesce, Gilda Pontieri, Debora Arpaia, Giovanni Sarnelli, Bernadette Biondi
No abstract text is available yet for this article.
July 13, 2017: Endocrine
https://www.readbyqxmd.com/read/28702888/cushing-s-syndrome-a-model-for-sarcopenic-obesity
#9
Michael Drey, Christina M Berr, Martin Reincke, Julia Fazel, Jochen Seissler, Jochen Schopohl, Martin Bidlingmaier, Stefanie Zopp, Nicole Reisch, Felix Beuschlein, Andrea Osswald, Ralf Schmidmaier
PURPOSE: Obesity and its metabolic impairments are discussed as major risk factors for sarcopenia leading to sarcopenic obesity. Cushing's syndrome is known to be associated with obesity and muscle atrophy. We compared Cushing's syndrome with matched obese controls regarding body composition, physical performance, and biochemical markers to test the hypothesis that Cushing's syndrome could be a model for sarcopenic obesity. METHODS: By propensity score matching, 47 controls were selected by body mass index and gender as obese controls...
July 12, 2017: Endocrine
https://www.readbyqxmd.com/read/28702887/ambulatory-blood-pressure-monitoring-derived-short-term-blood-pressure-variability-in-primary-hyperparathyroidism
#10
A Concistrè, A Grillo, G La Torre, R Carretta, B Fabris, L Petramala, C Marinelli, A Rebellato, F Fallo, C Letizia
INTRODUCTION: Primary hyperparathyroidism is associated with a cluster of cardiovascular manifestations, including hypertension, leading to increased cardiovascular risk. PURPOSE: The aim of our study was to investigate the ambulatory blood pressure monitoring-derived short-term blood pressure variability in patients with primary hyperparathyroidism, in comparison with patients with essential hypertension and normotensive controls. METHODS: Twenty-five patients with primary hyperparathyroidism (7 normotensive,18 hypertensive) underwent ambulatory blood pressure monitoring at diagnosis, and fifteen out of them were re-evaluated after parathyroidectomy...
July 12, 2017: Endocrine
https://www.readbyqxmd.com/read/28669056/pathogenic-th17-and-th22-cells-are-increased-in-patients-with-autoimmune-thyroid-disorders
#11
Marlen Vitales-Noyola, Ana M Ramos-Levi, Rebeca Martínez-Hernández, Ana Serrano-Somavilla, Miguel Sampedro-Nuñez, Roberto González-Amaro, Mónica Marazuela
PURPOSE: To study the levels of pathogenic and non-pathogenic Th17 and Th22 cells in autoimmune thyroid disorders patients. Although Th17 cells seem to play an important role in the pathogenesis of thyroid autoimmune disorders, the specific subsets of these lymphocytes have not been analyzed in this condition. METHODS: We assessed the levels of Th17 (pathogenic and non-pathogenic) and Th22 cells in peripheral blood and thyroid glands of autoimmune thyroid disorders patients (n   =  26, 16 with Graves' disease and 10 with Hashimoto's thyroiditis) and 15 healthy controls by multi-parametric flow cytometry and immunofluorescence microscopy...
July 1, 2017: Endocrine
https://www.readbyqxmd.com/read/28664310/plasma-levels-of-relaxin-2-are-higher-and-correlated-to-c-peptide-levels-in-early-gestational-diabetes-mellitus
#12
LETTER
Yoatzin Alonso Lopez, Jonatan Dereke, Mona Landin-Olsson, Helena Strevens, Charlotta Nilsson, Magnus Hillman
No abstract text is available yet for this article.
June 29, 2017: Endocrine
https://www.readbyqxmd.com/read/28664309/management-of-gastric-neuro-endocrine-tumours-in-a-large-french-national-cohort-gte
#13
Sylvain Manfredi, Thomas Walter, Eric Baudin, Romain Coriat, Philippe Ruszniewski, Thierry Lecomte, Anne-Pascale Laurenty, Bernard Goichot, Vincent Rohmer, Guillaume Roquin, Oana-Zvetlana Cojocarasu, Catherine Lombard-Bohas, Côme Lepage, Jeff Morcet, Guillaume Cadiot
INTRODUCTION: Gastric neuro-endocrine tumours are rare. European guidelines for the management of neuro-endocrine tumours have been published in 2012. The aim of our survey was to study the management of gastric neuro-endocrine tumours registered in the national cohort. A prospective national cohort registers the Neuro-endocrine tumours in France since January 2003 (GTE network). We reviewed all the individual medical reports of gastric neuro-endocrine tumours in order to collect data on treatment...
June 29, 2017: Endocrine
https://www.readbyqxmd.com/read/28660378/mineral-metabolism-abnormalities-in-patients-with-prostate-cancer-a-systematic-case-controlled-study
#14
Francesco Minisola, Cristiana Cipriani, Luciano Colangelo, Mirella Cilli, Alessandro Sciarra, Magnus Von Heland, Luciano Nieddu, Emanuela Anastasi, Roberto Pascone, Valeria Fassino, Daniele Diacinti, Flavia Longo, Salvatore Minisola, Jessica Pepe
PURPOSE: Prostate cancer is the most common tumor in men. To the best of our knowledge a systematic assessment of bone and mineral abnormalities has not been performed in prostatic cancer patients consecutively enrolled. METHODS: This study was therefore carried out to investigate changes of skeletal and mineral metabolism in patients with prostate cancer (n  = 69). A population of patients with cancer of various origin was also investigated as a control group (n  = 53), since a comparison with non-prostate cancer patients has not been previously reported...
June 28, 2017: Endocrine
https://www.readbyqxmd.com/read/28646379/comment-on-the-pros-and-cons-of-continuous-glucose-monitoring-for-patients-with-type-1-diabetes-on-multiple-daily-injections-of-insulin
#15
LETTER
Frontino Giulio, Favalli Valeria, Bonura Clara
No abstract text is available yet for this article.
June 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28646378/glucagon-stimulation-test-has-its-time-come
#16
EDITORIAL
Cesar L Boguszewski
No abstract text is available yet for this article.
June 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28646376/morphologic-and-molecular-pathway-of-cushing-syndrome-cardiomyopathy
#17
LETTER
Andrea Frustaci, Claudio Letizia, Cristina Chimenti
No abstract text is available yet for this article.
June 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28643243/toward-predictive-biomarkers-of-response-to-kinase-inhibitor-therapies-in-differentiated-thyroid-cancer
#18
EDITORIAL
Nicole M Iñiguez-Ariza, Keith C Bible
No abstract text is available yet for this article.
June 22, 2017: Endocrine
https://www.readbyqxmd.com/read/28638983/treatment-of-benign-thyroid-nodules-by-high-intensity-focused-ultrasound-hifu-at-different-acoustic-powers-a-study-on-in-silico-phantom
#19
Fabiano Bini, Pierpaolo Trimboli, Franco Marinozzi, Luca Giovanella
BACKGROUND: The non-surgical therapies of benign thyroid nodules are gaining momentum due to the possibility to reduce the nodule's volume and avoid surgery. As the last technique introduced, high intensity focused ultrasound allows the thermal tissue treatment by directing energy inside the targeted nodule with no invasive instruments. In the present study we applied the Food and Drug Administration high intensity focused ultrasound simulator to in-silico phantom to evaluate the effects obtained by different acoustic powers...
June 21, 2017: Endocrine
https://www.readbyqxmd.com/read/28634744/gain-of-function-snps-in-nlrp3-and-il1b-genes-confer-protection-against-obesity-and-t2d-undiscovered-role-of-inflammasome-genetics-in-metabolic-homeostasis
#20
LETTER
Juliana de Moraes Rodrigues, Dhemerson Souza de Lima, Vinicius N C Leal, Adriana A Bosco, Valeria Sandrim, Alessandra Pontillo
No abstract text is available yet for this article.
June 20, 2017: Endocrine
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