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Henrik Falhammar, Magnus Kjellman, Jan Calissendorff
PURPOSE: Many pheochromocytomas and paragangliomas (PPGLs) are nowadays diagnosed as incidentalomas or by screening. This may have changed outcomes. METHODS: We reviewed 110 consecutive cases of PPGLs. Two cases with concurrent ectopic ACTH-syndrome were excluded. RESULTS: Sixty-five percent had presented as incidentalomas, 30% as symptomatic PPGLs, and 5% had been screened (previously diagnosed MEN2A). Doxazosin was used in 79%, phenoxybenzamine in 18%, intravenous phentolamine in 1%, and no alpha-blockade in the rest...
September 15, 2018: Endocrine
Eunice Nyasani, Iqbal Munir, Mia Perez, Kimberly Payne, Salma Khan
Obesity is related to many major diseases and cancers. Women have higher rates of obesity and obesity is linked to commonly occurring cancers in women. However, there is a lack of knowledge of the unique mechanism(s) involved in each type of cancer. The objective of this review is to highlight the need for novel experimental approaches and a better understanding of the common and unique pathways to resolve controversies regarding the role of obesity in cancer. In women, there is a link between hormones and obesity-associated genes in cancer development...
September 14, 2018: Endocrine
Rudolf A Werner, Ralph A Bundschuh, Takahiro Higuchi, Mehrbod S Javadi, Steven P Rowe, Norbert Zsótér, Matthias Kroiss, Martin Fassnacht, Andreas K Buck, Michael C Kreissl, Constantin Lapa
PURPOSE: The metabolically most active lesion in 2-deoxy-2-(18 F)fluoro-D-glucose (18 F-FDG) PET/CT can predict progression-free survival (PFS) in patients with medullary thyroid carcinoma (MTC) starting treatment with the tyrosine kinase inhibitor (TKI) vandetanib. However, this metric failed in overall survival (OS) prediction. In the present proof of concept study, we aimed to explore the prognostic value of intratumoral textural features (TF) as well as volumetric parameters (total lesion glycolysis, TLG) derived by pre-therapeutic 18 F-FDG PET...
September 11, 2018: Endocrine
Emir Celik, Hande Mefkure Ozkaya, Burc Cagri Poyraz, Tarik Saglam, Pinar Kadioglu
OBJECTIVE: To assess prospectively the prevalence of impulse control disorders (ICD), psychiatric symptoms, and their clinical correlates in patients with prolactinoma receiving dopamine agonists (DA) in comparison to those with non-functioning pituitary adenomas (NFA) and healthy controls (HC). METHODS: A total of 25 patients with prolactinoma, 31 with NFA, and 32 HCs were included in the study. All patients and controls were screened for the presence of ICDs and other psychiatric disorders using revised version of Minnesota Impulsive Disorders Interview (MIDI-R), Barratt Impulsiveness Scale (BIS-11), Symptom Check List (SCL-90-R) questionnaire and Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI)...
September 11, 2018: Endocrine
Hisako Komada, Yushi Hirota, Kazuhiko Sakaguchi, Yoko Okuno, Wataru Ogawa, Susumu Seino
PURPOSE: Fulminant type 1 diabetes mellitus (FT1DM), characterized by rapid and almost complete destruction of pancreatic β-cells, is a newly identified subtype of type 1 diabetes mellitus. Although, the pathophysiology of this condition remains still unclear, histological evidence suggests that not only β-cells but also α-cells of pancreatic islets are reduced in number in FT1DM. However, the ability of glucagon secretion in patients with this condition has remained largely uncharacterized...
September 10, 2018: Endocrine
Barry Gumbiner, Brooke Esteves, Vanessa Dell, Tenshang Joh, Pamela D Garzone, Alison Forgie, Chandrasekhar Udata
PURPOSE: This first-in-human study assessed safety, immunogenicity, pharmacokinetics, and pharmacodynamics of RN909, a monoclonal antibody antagonist of the glucagon receptor, in type 2 diabetes (T2DM) subjects. METHODS: This study enrolled 84 T2DM subjects receiving stable metformin regimens. Forty-four subjects were randomized to receive single escalating doses of RN909 (0.3 to 6 mg/kg subcutaneously (SC), or 1 mg/kg intravenously (IV)), or placebo; 40 subjects were randomized to receive multiple escalating doses (50 to 150 mg SC) or placebo every 4 weeks for 12 weeks...
September 10, 2018: Endocrine
Ting Gu, Ying-Li Lu, Bing Han, Bo-Ren Jiang, Li-Zhen Wang, Li-Zhen Yang, Yong-Shun Han
PURPOSE: To determine whether ectopic thyroid had the same computed tomography (CT) value as orthotopic thyroid. METHODS: Twenty-one patients with 23 ectopic thyroids and 23 controls with orthotopic thyroids underwent CT scans and were included in this retrospective study. The CT images were reviewed in a blinded fashion by two radiologists. Independent-Samples T-test was used for comparison of CT attenuation values between two groups. RESULTS: Ectopic thyroids had significantly lower non-enhanced attenuation (91...
September 10, 2018: Endocrine
Barbara Altieri, Giovanna Muscogiuri, Stavroula A Paschou, Andromachi Vryonidou, Silvia Della Casa, Alfredo Pontecorvi, Martin Fassnacht, Cristina L Ronchi, John Newell-Price
The original version of this article unfortunately contained a mistake in Figure 1. There is a typo in the word "osteoclastogenesis" and the word "activity" is missing in the same entity. It should be "osteoclastogenesis" instead of "osteoclestogenesis".
September 10, 2018: Endocrine
Tao Xie, Hailin Ding, Mingfeng Xia, Xiaobiao Zhang, Wei Sun, Tengfei Liu, Ye Gu, Chongjing Sun, Fan Hu
PURPOSE: Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdominal AT correlated with surgical treatment in patients with acromegaly. METHODS: Abdominal AT in 17 acromegaly patients (group 1) was studied longitudinally preoperatively and 1 month to 1 year postoperatively...
September 10, 2018: Endocrine
Panagiotis Anagnostis, Pavlos Siolos, Nifon K Gkekas, Nikoletta Kosmidou, Aikaterini-Maria Artzouchaltzi, Konstantinos Christou, Stavroula A Paschou, Michael Potoupnis, Eustathios Kenanidis, Eleftherios Tsiridis, Irene Lambrinoudaki, John C Stevenson, Dimitrios G Goulis
PURPOSE: Early menopause (EM, age at menopause < 45 years) and premature ovarian insufficiency (POI, age at menopause < 40 years) are associated with an increased risk of osteoporosis. However, their association with increased fracture risk has not been established, with studies yielding conflicting results. The primary aim of this systematic review and meta-analysis was to synthesize studies evaluating the association between age at menopause and fracture risk. The secondary aim was to evaluate this effect concerning the site of fractures...
September 10, 2018: Endocrine
Ulla Feldt-Rasmussen, Marianne Klose, Salvatore Benvenga
Central hypothyroidism is defined as low circulating free thyroxine (free T4) with inappropriately low circulating thyrotropin (TSH), in context of a hypothalamic pituitary pathology. Rare cases of idiopathic central hypothyroidism caused by a functional defect may occur, and the condition is often overlooked due to difficulty in achieving the correct diagnosis, sparse symptomatology of the condition and a high risk of misinterpretion of the biochemical changes in central hypothyroidism. Central hypothyroidism is mainly seen in patients with hypothalamic-pituitary pathology due to one of many possible aetiologies, where other hormone deficiencies often co-exist, and both the presence of other deficiencies and their replacement have a strong influence on the measurement of the thyroid-related hormones and thereby interpretation of the thyroid function variables in relation to the clinical impact of thyroid hormone substitution therapy...
September 6, 2018: Endocrine
Darya Saeed Abdulateef, Taha Othman Mahwi
PURPOSE: Hypothyroidism is associated with an increase in serum cortisol level while the long-term activity of hypothalamic-pituitary-adrenal (HPA) axis in hypothyroid, and subclinical hypothyroid (SCH) subjects has not been studied. This study aimed to assess the hair cortisol levels as a long-term activity of HPA axis in hypothyroid, SCH and a group of healthy adult subjects. Also, it aimed to examine the correlation of hair cortisol levels with hypothalamic-pituitary-thyroid (HPT) axis and anthropometric measures...
September 6, 2018: Endocrine
Thiago Gagliano-Jucá, Zhuoying Li, Karol M Pencina, Yusnie M Beleva, Olga D Carlson, Josephine M Egan, Shehzad Basaria
PURPOSE: Precise evaluation of serum testosterone levels is important in making an accurate diagnosis of androgen deficiency. Recent practice guidelines on male androgen deficiency recommend that testosterone be measured in the morning while fasting. Although there is ample evidence regarding morning measurement of testosterone, studies that evaluated the effect of glucose load or meals were limited by inclusion of hypogonadal or diabetic men, and measurement of testosterone was not performed using mass spectrometry...
September 6, 2018: Endocrine
Mahmoud Al Majdoub, Mikael Lantz, Peter Spégel
No abstract text is available yet for this article.
September 3, 2018: Endocrine
Justine Herndon, Ashley M Nadeau, Caroline J Davidge-Pitts, William F Young, Irina Bancos
PURPOSE: Evidence on clinical presentation, evaluation, and management of patients with primary adrenal insufficiency (PAI) due to bilateral adrenal infiltrative disease is scarce. Our objective was to review the clinical presentation, biochemical work-up, imaging findings, and management of patients with PAI due to infiltrative adrenal disease in order to determine the best diagnostic and management approach. METHODS: Retrospective study of patients with PAI due to bilateral infiltrative adrenal disease referred for adrenal biopsy during 2000-2014 at Mayo Clinic, Rochester, Minnesota...
September 3, 2018: Endocrine
Ottavio Cavicchi, Luca Burgio, Eleonora Cioccoloni, Ottavio Piccin, Giovanni Macrì, Patrizia Schiavon, Gianlorenzo Dionigi
PURPOSE: To evaluate the reliability of intermittent intraoperative neuromonitoring (I-IONM) through recurrent laryngeal nerve (RLN) stimulation and laryngeal palpation in predicting postoperative vocal cord palsy and to examine the reliability of this technique in providing useful information in the decision to perform a staged surgery in initially planned total thyroidectomy. METHODS: This was a retrospective cohort study of patients who underwent thyroid surgery at the ENT Department of the University of Bologna from January 2014 to June 2017...
September 1, 2018: Endocrine
Massimo Porta, Cristina Amione, Federica Barutta, Paolo Fornengo, Stefano Merlo, Gabriella Gruden, Luigi Albano, Marco Ciccarelli, Paola Ungaro, Marilena Durazzo, Francesco Beguinot, Paola Berchialla, Franco Cavallo, Marina Trento
PURPOSE: We examined the expression of a panel of epigenetic enzymes catalyzing histone tails post-transcriptional modifications, together with effectors of metabolic and inflammatory alterations, in type 2 diabetes. METHODS: Cross-sectional, case-control study of 21 people with type 2 diabetes and 21 matched controls. Total RNA was extracted from white cells and reverse transcribed. PCR primer assays for 84 key genes encoding enzymes known to modify genomic DNA and histones were performed...
September 1, 2018: Endocrine
Cínthia Minatel Riguetto, Arnaldo Moura Neto, Marcos Antônio Tambascia, Denise Engelbrecht Zantut-Wittmann
PURPOSE: To assess quality of life (QoL) and cognitive function among Graves' disease (GD) patients with different thyroid status, with and without ophthalmopathy. METHODS: This is a cross-sectional clinic-based study involving 154 patients with GD (81.27% were female, mean age 45.6 ± SD 11.2 years) and 54 (35.06%) had ophthalmopathy. Data were collected after an informed consent from all patients was obtained. All patients completed the 36-Item Short Form Health Survey and Mini-Mental State Examination...
September 1, 2018: Endocrine
Lucia Torres-García, Ricardo M Cerda-Flores, Marcela Márquez
PURPOSE: To review incidence, treatment and outcome of pediatric pituitary adenomas (PAs). METHODS: A follow-up study patients with the age of ≤19 years old who were treated from 1995 to 2015 in Mexico. RESULTS: Out of 1244 diagnosed PA, 43 patients were children (35 females, 8 males) with a mean age of 17.2 years. The majority were macroadenomas (70%) with prolactinomas (PRL) dominating (63%) followed by non-functioning adenomas (21%). In total, 40% were diagnosed as invasive...
August 31, 2018: Endocrine
Fangfang Jiao, Eric Yuk Fai Wan, Colman Siu Cheung Fung, Anca Ka Chun Chan, Sarah Morag McGhee, Ruby Lai Ping Kwok, Cindy Lo Kuen Lam
PURPOSE: The multidisciplinary Risk Assessment and Management Program for patients with diabetes mellitus (RAMP-DM) was found to be cost-saving in comparison with usual primary care over 5 years' follow-up. This study aimed to estimate the cost-effectiveness of RAMP-DM over lifetime. METHODS: We built a Discrete Event Simulation model to evaluate the cost-effectiveness of RAMP-DM over lifespan from public health service provider's perspective. Transition probabilities among disease states were extrapolated from a cohort of 17,140 propensity score matched participants in RAMP-DM and those under usual primary care over 5-year's follow-up...
August 28, 2018: Endocrine
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