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Guido Zavatta, Guido Di Dalmazi, Carmine Pizzi, Giovanni Bracchetti, Cristina Mosconi, Caterina Balacchi, Uberto Pagotto, Valentina Vicennati
OBJECTIVE: Primary aldosteronism is associated with higher cardiovascular morbidity as compared with essential hypertension. Vascular complications encompass myocardial infarction and cerebrovascular events. Aortic damage in primary aldosteronism has never been explored, although a few cases of ascending aorta aneurisms have been reported. DESIGN AND METHODS: We consecutively enrolled patients affected by primary aldosteronism (n = 45) and compared them with patients affected by essential hypertension (n = 47), on an outpatient setting...
November 14, 2018: Endocrine
Run-Bao Yang, Feng-Fei Lin, Jun Yang, Bin Chen, Ming-Hua Zhang, Qiao-Ping Lu, Bo Xiao, Yan Liu, Ke Zheng, Yong-Rong Qiu
PURPOSE: Osteoporosis is a condition characterized by decreased bone density and bone strength, commonly observed among older individuals. Caveolin-3 (CAV3) is a principal structural protein of the caveolae membrane domains, which has been reported to participate in cell signaling as well as the maintenance of cell structure. The aim of the current study was to investigate the effects involved with the silencing of CAV3 on bone formation among osteoporotic rat models via the Wnt signaling pathway...
November 14, 2018: Endocrine
Magdalena Szopa, Bartlomiej Matejko, Damian Ucieklak, Agata Uchman, Jerzy Hohendorff, Sandra Mrozińska, Wojciech Głodzik, Barbara Zapała, Teresa Płatek, Iwona Solecka, Cyrus M Sani, Maciej T Małecki
AIM: The impact of maturity onset diabetes of the young (MODY) on quality of life (QoL) has never been examined. We assessed disease impact on QoL among patients with HNF1A-MODY and GCK mutation carrier status. METHODS: The study included 80 patients with HNF1A-MODY and 89 GCK gene mutation carriers. We also examined 128 type 1 diabetes (T1DM) patients for comparison. Diabetes-specific QoL was assessed using the Audit of Diabetes Dependent Quality of Life questionnaire...
November 12, 2018: Endocrine
Erin Wesner, Calvin T Sung, Sharon E Jacob
No abstract text is available yet for this article.
November 12, 2018: Endocrine
Ramon V Cortez, Carla R Taddei, Luiz G Sparvoli, Ana G S Ângelo, Marina Padilha, Rosiane Mattar, Silvia Daher
PURPOSE: Gestational diabetes mellitus (GDM), the major endocrine pathology in pregnancy, has been associated with the development of an intense inflammatory process and increased insulin resistance. The maternal microbiota is involved in several metabolic functions; however, its role in GDM physiopathology remains unclear. The aim of this study was to assess the composition of the microbiota at different sites and evaluate its relationship with the occurrence of GDM. METHODS: This cross-sectional study recruited women in the third trimester of gestation with and without GDM...
November 12, 2018: Endocrine
Georgiana Dobri, Soamsiri Niwattisaiwong, James F Bena, Manjula Gupta, John Kirwan, Lawrence Kennedy, Amir H Hamrahian
PURPOSE: The growth hormone (GH) nadir during oral glucose tolerance test (OGTT) is the gold standard diagnostic test for acromegaly. The utility of OGTT-GH suppression test in patients with abnormal glucose metabolism (AGM) has not been well established. In this study, we compared the GH nadir during OGTT in patients evaluated for acromegaly in the presence and absence of AGM. METHODS: This is a retrospective cohort study of patients with acromegaly (G1, n = 40) and a group in whom acromegaly was not confirmed (G2, n = 53) who had OGTT-GH suppression test during 2000-2012, using a monoclonal GH immunoenzymatic assay...
November 10, 2018: Endocrine
Yair Liel, Muhammad Abu Tailakh
PURPOSE: Bisphosphonates are the mainstay of the treatment of Paget's disease of bone (PDB). Clinical practice guidelines recommend treatment with intravenous zoledronic acid or high-dose oral nitrogen bisphosphonates (N-BPs). We present our long-term experience treating PDB patients with lower than recommended oral doses of N-BPs, equivalent to once-weekly doses used for treating osteoporosis. METHODS: PDB patients were seen, between 1990 and 2015 at the endocrine clinic of an academic medical center...
November 8, 2018: Endocrine
Yushi Hirota, Tomokazu Matsuda, Shinsuke Nakajima, Michinori Takabe, Naoko Hashimoto, Tomoaki Nakamura, Yuko Okada, Kazuhiko Sakaguchi, Wataru Ogawa
PURPOSE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are categorized as short- or long-acting types, but information regarding differences in the effects of these two types on postprandial glucose disposal has been limited. We have now investigated the effects of exenatide and liraglutide (short- and long-acting GLP-1RAs, respectively) on glucose disposal during an oral glucose tolerance test (OGTT). METHODS: Fourteen healthy volunteers with normal glucose tolerance underwent three OGTTs, which were performed without pharmacological intervention or after a single administration of exenatide or liraglutide at 30 min and 10 h, respectively, before test initiation...
November 8, 2018: Endocrine
Anna Ferrulli, Concetta Macrì, Ileana Terruzzi, Federico Ambrogi, Valentina Milani, Michela Adamo, Livio Luzi
PURPOSE: In obesity, metabolic and voluntary factors regulate appetite, and a dysregulation of the reward pathway was demonstrated in all addiction disorders. Deep transcranial magnetic stimulation (dTMS) is already used to modulate cerebral dopamine activation in neuro-psychiatric diseases. We presently assess the acute effect of high frequency (HF) and low frequency (LF) dTMS on the modulation of the main neuropeptides and neurotransmitters involved in the reward pathway in obese subjects...
November 8, 2018: Endocrine
(no author information available yet)
No abstract text is available yet for this article.
November 8, 2018: Endocrine
Michael Glicksman, Shivraj Grewal, Shrayus Sortur, Brent S Abel, Sungyoung Auh, Trudy R Gaillard, Kwame Osei, Ranganath Muniyappa
PURPOSE: Current reference methods for measuring glucose effectiveness (GE) are the somatostatin pancreatic glucose clamp and minimal model analysis of frequently sampled intravenous glucose tolerance test (FSIVGTT), both of which are laborious and not feasible in large epidemiological studies. Consequently, surrogate indices derived from an oral glucose tolerance test (OGTT) to measure GE (oGE) have been proposed and used in many studies. However, the predictive accuracy of these surrogates has not been formally validated...
November 6, 2018: Endocrine
Claire Briet, Mirela Diana Ilie, Emmanuelle Kuhn, Luigi Maione, Sylvie Brailly-Tabard, Sylvie Salenave, Bertrand Cariou, Philippe Chanson
CONTEXT: Untreated acromegaly is associated with increased morbidity and mortality due to malignant, cardiovascular, and cerebrovascular disorders. Effective treatment of acromegaly reduces excess mortality, but its impact on cardiovascular risk factors and metabolic parameters are poorly documented. AIM: We analyzed changes in cardiovascular risk factors and metabolic parameters in patients receiving various treatment modalities. PATIENTS AND METHODS: We retrospectively studied 96 patients with acromegaly, both at diagnosis and after IGF-I normalization following surgery alone (n = 51) or medical therapy with first generation somatostatin analogues (SSA, n = 23), or pegvisomant (n = 22)...
November 5, 2018: Endocrine
Michelle L Maugham, Inge Seim, Patrick B Thomas, Gabrielle J Crisp, Esha T Shah, Adrian C Herington, Laura S Gregory, Colleen C Nelson, Penny L Jeffery, Lisa K Chopin
PURPOSE: The ghrelin axis regulates many physiological functions (including appetite, metabolism, and energy balance) and plays a role in disease processes. As ghrelin stimulates prostate cancer proliferation, the ghrelin receptor antagonist [D-Lys3 ]-GHRP-6 is a potential treatment for castrate-resistant prostate cancer and for preventing the metabolic consequences of androgen-targeted therapies. We therefore explored the effect of [D-Lys3 ]-GHRP-6 on PC3 prostate cancer xenograft growth...
November 2, 2018: Endocrine
Martin Freesmeyer, Falk Gühne, Christian Kühnel, Thomas Opfermann, Thomas Winkens, Anke Werner
PURPOSE: Renal function and effective half-life (t1/2,eff ) of I-131 have not been fully elucidated in patients undergoing radioiodine therapy (RAIT) for differentiated thyroid cancer (DTC). Aim of the present analysis was to evaluate the potential of cystatin C-based estimated glomerular filtration rate (eGFRCysC ) in comparison to conventional creatinine (eGFRCrea ) and to verify which methods to determine t1/2,eff are most accurate to predict t1/2,eff . METHODS: Forty-eight patients receiving whole-body I-131-scintigraphy were included...
November 1, 2018: Endocrine
Andrea Giustina
No abstract text is available yet for this article.
October 31, 2018: Endocrine
Philippe Caron, Thierry Brue, Gérald Raverot, Antoine Tabarin, Anne Cailleux, Brigitte Delemer, Peggy Pierre Renoult, Aude Houchard, Fatine Elaraki, Philippe Chanson
The original version of this article unfortunately contained a mistake in corresponding author name as Philippe Chanson in the affiliation section.
October 31, 2018: Endocrine
Juan Chen, Shanhu Qiu, Haijian Guo, Wei Li, Zilin Sun
PURPOSE: Promoting urine glucose excretion (UGE) is an attractive approach for the treatment of diabetes. Obesity is associated with increased risk for type 2 diabetes. This study was aimed to investigate the association of waist-to-hip ratio (WHR), a simple measure of abdominal obesity, with UGE determined in subjects without previous history of diabetes. METHODS: We studied the correlation of WHR with UGE in 7485 participants without previous history of diabetes...
October 31, 2018: Endocrine
Elisabetta Morini, Antonino Catalano, Antonino Lasco, Nunziata Morabito, Salvatore Benvenga
PURPOSE: Calcium carbonate was previously shown to interfere with L-thyroxine absorption. To estimate the magnitude of tablet L-thyroxine malabsorption caused by calcium carbonate, with resulting increase in serum thyrotropin (TSH), we performed a cohort study in a referral care center. METHODS: Fifty postmenopausal hypothyroid L-thyroxine-treated women (age 71.7 ± 5.1 years) who added calcium supplementation (600-1000 mg/day) were considered. They were taking L-thyroxine 45-60 min before breakfast (setting 1)...
October 27, 2018: Endocrine
Martina Fragni, Chiara Fiorentini, Elisa Rossini, Simona Fisogni, Sara Vezzoli, Sara A Bonini, Cristina Dalmiglio, Salvatore Grisanti, Guido A M Tiberio, Melanie Claps, Deborah Cosentini, Valentina Salvi, Daniela Bosisio, Massimo Terzolo, Cristina Missale, Fabio Facchetti, Maurizio Memo, Alfredo Berruti, Sandra Sigala
PURPOSE: The management of patients with adrenocortical carcinoma (ACC) is challenging. As mitotane and chemotherapy show limited efficacy, there is an urgent need to develop therapeutic approaches. The aim of this study was to investigate the antitumor activity of progesterone and explore the molecular mechanisms underlying its cytotoxic effects in the NCI-H295R cell line and primary cell cultures derived from ACC patients. METHODS: Cell viability, cell cycle, and apoptosis were analyzed in untreated and progesterone-treated ACC cells...
October 26, 2018: Endocrine
Masaaki Matsumoto, Hiroyuki Awano, Yushi Hirota, Masashi Nagai, Ryosuke Bo, Atsuko Matsuoka, Tetsushi Hamaguchi, Takehito Takeuchi, Yasushi Nakagawa, Wataru Ogawa, Kazumoto Iijima
PURPOSE: Hypoglycemia is a common and life-threatening complication in type 1 diabetes mellitus (T1DM) patients. Current guidelines recommend glucagon for treating hypoglycemia in out-of-hospital settings; however, glucagon is reportedly underused in such patients. We conducted a doctor-oriented, questionnaire-based survey of pediatricians and physicians to determine the glucagon prescription rate and identify the reason(s) for its underuse in T1DM patients. METHODS: A questionnaire was mailed to 415 pediatricians and 200 physicians employed at 66 facilities with >100 general wards throughout Hyogo, Japan...
October 26, 2018: Endocrine
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