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Acta Microbiologica et Immunologica Hungarica

Szabolcs Vigvári, Áron Vincze, Jenő Solt, Dávid Sipos, Zsófia Feiszt, Beáta Kovács, Ágnes Kappéter, Zoltán Péterfi
Dramatic changes in the epidemiology of Clostridium difficile infections have been reported from the western world in the past decade. The proportion of severe cases is significantly elevating and clinicians now have to contend with the problem of additional and more frequent episodes of recurrences including an upward trend in the mortality rate. This situation led us to investigate the possibility of the fecal microbiota transplantation (FMT). An amount of 100 ml of fecal microbiota solution was instilled into a nasojejunal (NJ) tube in 16 cases and into a nasogastric (NG) tube in 44 cases...
December 26, 2018: Acta Microbiologica et Immunologica Hungarica
Lyudmila Boyanova, Petyo Hadzhiyski, Rumyana Markovska, Penka Yaneva, Daniel Yordanov, Galina Gergova, Ivan Mitov
Helicobacter pylori positivity was assessed among 656 symptomatic children in 2010-2017. Overall infection prevalence was 24.5% and a significantly higher rate was detected in girls (28.5%) compared to boys (20.0%). Moreover, in children with duodenal ulcer, H. pylori prevalence was higher (47.4%) compared with the rest (23.9%). On the contrary, the infection was detected 1.9-fold less frequently in patients with GERD (14.5%) compared with the other (27.0%) patients and 2.1-fold less often in the presence of duodenogastric reflux (bile) reflux (13...
December 26, 2018: Acta Microbiologica et Immunologica Hungarica
Sezer Okay, Rukiye Çetin, Fatih Karabulut, Cennet Doğan, Süheyla Sürücüoğlu, Aslıhan Kurt Kızıldoğan
Immunogenic potency of the recombinant Erp, HspR, LppX, MmaA4, and OmpA proteins from Mycobacterium tuberculosis (MTB), formulated with Montanide ISA 720 VG adjuvant, was evaluated in BALB/c mice for the first time in this study. The five vaccine formulations, adjuvant, and BCG vaccine were subcutaneously injected into mice, and the sera were collected at days 0, 15, 30, 41, and 66. The humoral and cellular immune responses against vaccine formulations were determined by measuring serum IgG and serum interferon-gamma (IFN-γ) and interleukin-12 (IL-12) levels, respectively...
November 28, 2018: Acta Microbiologica et Immunologica Hungarica
Elena Nikolaevna Filatova, Nikolay Aleksandrovich Sakharnov, Dmitry Igorevich Knyazev, Oleg Vladimirovich Utkin
Transforming growth factor β 1 (TGFB1) likely contributes to the pathogenesis of Epstein-Barr virus (EBV)-mediated cancer. A microarray containing 59 probes for detecting mRNA of members of TGFB1-associated pathways was developed. mRNA expression of TGFB1 receptors and members of connected pathways were examined in peripheral blood leukocytes of patients during acute EBV infection and after recovery. TGFB1 and TGFBR2 mRNA expression was increased in patients with EBV infection. Similarly, mRNA expression of protein kinase C (PRKCB), MAP3K7, PDLIM7, and other members of TGFB1 and NF-κB signaling pathways increased...
November 22, 2018: Acta Microbiologica et Immunologica Hungarica
Asieh Taji, Hamid Heidari, Hadi Sedigh Ebrahim-Saraie, Jamal Sarvari, Mohammad Motamedifar
Multiple drug-resistant enterococci are major cause of healthcare-associated infections due to their antibiotic resistance traits. Among them, Enterococcus faecalis is an important opportunistic pathogen causing various hospital-acquired infections. A total of 53 E. faecalis isolates were obtained from various infections. They were identified by phenotypic and genotypic methods. Determination of antimicrobial resistance patterns was done according to CLSI guidelines. The isolates that were non-susceptible to at least one agent in ≥3 antimicrobial categories were defined as multidrug-resistant (MDR)...
November 22, 2018: Acta Microbiologica et Immunologica Hungarica
Dániel Gulyás, Béla Kocsis, Dóra Szabó
Fluoroquinolone resistance in Enterobacteriales is developed by chromosomal and plasmid-mediated mechanisms. Plasmids play an important role in dissemination of resistant genes and they carry genes that protect bacteria in different stress-induced situations. In this study, we studied Escherichia coli strains, each carried one plasmid-mediated quinolone resistance determinant namely, qnrA1, qnrB1, qnrC1, and qnrD1. We exposed 0.5 McFarland density of each strain to 0.5 mg/L ciprofloxacin from the period of 30, 60, 90, and 120 min over 24 h...
November 22, 2018: Acta Microbiologica et Immunologica Hungarica
Audrone Muleviciene, Federica D'Amico, Silvia Turroni, Marco Candela, Augustina Jankauskiene
Nutritional iron deficiency (ID) causes not only anemia but also malfunction of the entire human organism. Recently, a role of the gut microbiota has been hypothesized, but limited data are available especially in infants. Here, we performed a pilot study to explore the gut microbiota in 10 patients with iron deficiency anemia (IDA) and 10 healthy controls aged 6-34 months. Fresh stool samples were collected from diapers, and the fecal microbiota was profiled by next-generation sequencing of the V3-V4 hypervariable region of the 16S rRNA gene...
November 12, 2018: Acta Microbiologica et Immunologica Hungarica
Rosa M Lopez-Gigosos, Alberto Mariscal, Mario Gutierrez-Bedmar, Macarena Real, Eloisa Mariscal-López
The success of Acinetobacter baumannii as an emerging organism is probably linked to its high resistance to adverse environmental conditions. This study was conducted to analyze the association between some factors that may favor the dissemination of A. baumannii clinical isolates. A total of 47 clinical strains of A. baumannii were evaluated to carbapenem, the ability to produce biofilm, the susceptibility to some antiseptics, and the survival time on cotton fabrics. Most of the isolates were resistant to carbapenem (72...
November 7, 2018: Acta Microbiologica et Immunologica Hungarica
Serap Süzük Yıldız, Banu Kaşkatepe, Hüsniye Şimşek, Fatma Mutlu Sarıgüzel
When the problem with carbapenem-resistant Enterobacteriaceae (CRE) increases, the older antimicrobial agents such as colistin and fosfomycin are used for the treatment of these infections. In this study, the broth microdilution method for colistin and the agar dilution method for fosfomycin were used for a total of 147 multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains of CRE. The study included Klebsiella pneumoniae (91.16%), Escherichia coli (7.48%), Enterobacter cloacae (0.68%), and Serratia marcescens (0...
November 7, 2018: Acta Microbiologica et Immunologica Hungarica
Ahmed Gaballah, Amira Elbaradei, Amel Elsheredy, Ola Kader
Thirty-three Pseudomonas aeruginosa isolates, resistant to one or more β-lactams, were included in this study. Identification of tested strains was confirmed using MALDI-TOF/MS. Phenotypic and genotypic β-lactamase patterns were investigated. Most of the isolates were resistant to carbapenems (32 out of 33) and to the extended-spectrum cephalosporins (ESC) (30 out of 33). Phenotypically, the production of extended-spectrum beta-lactamase (ESBL), metallo-β-lactamases (MBL), and carbapenemases was detected in 10, 23, and 9 isolates, respectively...
November 7, 2018: Acta Microbiologica et Immunologica Hungarica
Dóra Szabó
No abstract text is available yet for this article.
December 1, 2018: Acta Microbiologica et Immunologica Hungarica
Seyedeh Marzieh Jabbari Shiadeh, Ali Hashemi, Fatemeh Fallah, Parnian Lak, Leila Azimi, Marjan Rashidan
Enterococcus faecalis is one of the most significant pathogen in both nosocomial and community-acquired infections. Reduced susceptibility to antibiotics is in part due to efflux pumps. This study was conducted on 80 isolates of E. faecalis isolated from outpatients with urinary tract infection during a period of 1 year from April 2014 to April 2015. The antibiotic susceptibility patterns of isolates were determined by the disk diffusion method and presence of efrA and efrB genes was detected by PCR and sequencing...
September 24, 2018: Acta Microbiologica et Immunologica Hungarica
Umut Safiye Say Coskun, Zahide Asık
The Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne virus, whose viral RNA consists of S, L, and M segments. The virus is migrating through the ticks with animals and migratory birds and the geographical distribution can be investigated based on genetic analysis. To better understand the connection between the seropositivity and the mortality rate, the key factor could be the temporal and spatial analysis of the different strains. In this study, serum samples (n = 26) were selected from CCHFV RNA-positive patients and subjected to sequence analysis of the gene regions encoding the S segments...
September 11, 2018: Acta Microbiologica et Immunologica Hungarica
Tereza Zakova, Johana Rondevaldova, Andrea Bernardos, Premysl Landa, Ladislav Kokoska
Staphylococcus aureus is a major human pathogen that is responsible for both hospital- and community-acquired infections. Stilbenes are polyphenol compounds of plant origin known to possess a variety of pharmacological properties, such as antibacterial, antiviral, and antifungal effects. This study reports the in vitro growth-inhibitory potential of eight naturally occurring stilbenes against six standard strains and two clinical isolates of S. aureus, using a broth microdilution method, and expressing the results as minimum inhibitory concentrations (MICs)...
September 11, 2018: Acta Microbiologica et Immunologica Hungarica
Mojtaba Moosavian, Sakineh Seyed-Mohammadi, Ahmad Farajzadeh Sheikh, Saeed Khoshnood, Aram Asarehzadegan Dezfuli, Morteza Saki, Gholamreza Ghaderian, Fatemeh Shahi, Mahtab Abdi, Fariba Abbasi
Shigella spp. are a major cause of bacillary dysentery, particularly among children in developing countries such as Iran. This study aimed to investigate the presence of two important Shigella enterotoxins (ShET-1 and ShET-2), encoded by the set and sen genes, respectively, by polymerase chain reaction (PCR) assay among Shigella species isolated from children affected by shigellosis in Ahvaz, southwest of Iran. In this cross-sectional study, from June 2016 to April 2017, altogether 117 Shigella isolates were collected from fecal specimens of children aged <15 years with diarrhea in Ahvaz, southwest Iran...
September 11, 2018: Acta Microbiologica et Immunologica Hungarica
Mehdi Moghadampour, Azhar Salari-Jazi, Jamshid Faghri
The objective of this study was to assess the prevalence, antibiogram, and related genes of carbapenem-resistant Klebsiella pneumoniae (CRKP) among hospital environment samples. A total of 250 samples were taken from different surfaces and medical devices of three hospitals in Isfahan, Iran. All samples were cultured and K. pneumoniae strains were identified by conventional microbiological methods and polymerase chain reaction (PCR). Antibiogram of isolates was performed by disk diffusion method and production of carbapenemases and metallo-β-lactamases (MBLs) was confirmed using modified Hodge test and E-test, respectively...
August 16, 2018: Acta Microbiologica et Immunologica Hungarica
Smiline As Girija, Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam
Carbapenems are administered as the final drug of choice for treating complicated nosocomial infections caused by multidrug-resistant Acinetobacter baumannii strains. It is currently a worldwide issue that metallo-β-lactamases (MBLs) as carbapenem-hydrolyzing enzymes are one of the major drug resistance mechanisms. This investigation is thus aimed to assess the prevalence and characterize the MBL-producing strains of A. baumannii both by phenotypic assays and by genotypic characterization. A total of 73 isolates of A...
August 16, 2018: Acta Microbiologica et Immunologica Hungarica
Adrienn Hanczvikkel, Miklós Füzi, Erika Ungvári, Ákos Tóth
Silver is used extensively in both hospitals and outpatient clinics as a disinfectant coating agent on various devices. Resistance to silver was recently reported as an emerging problem in Enterobacteriaceae. Multidrug-resistant high-risk clones of Klebsiella pneumoniae are common causes of serious healthcare-associated infections worldwide posing a serious threat to patients. In this study, we investigated the capacity of both high-risk (CG14/15 and CG258) and minor clone strains of K. pneumoniae to develop resistance to silver...
August 1, 2018: Acta Microbiologica et Immunologica Hungarica
Mehdi Moghadampour, Aliakbar Rezaei, Jamshid Faghri
The aim of this study was to investigate the prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) and the most common types of carbapenemases, metallo-beta-lactamases (MBLs), and extended-spectrum beta-lactamases (ESBLs) among CRKP isolates in a tertiary hospital in Isfahan, Iran. Eighty non-repetitive clinical isolates of K. pneumoniae were obtained from different clinical specimens. Antibiotic resistance pattern of isolates was determined by disk diffusion method and production of carbapenemases and MBLs was confirmed using modified Hodge test and E-test, respectively...
August 1, 2018: Acta Microbiologica et Immunologica Hungarica
Joana Korabliovienė, Mykolas Mauricas, Česlova Ambrozevičienė, Mindaugas Valius, Algirdas Kaupinis, Saulius Čaplinskas, Pavel Korabliov
The aim of this study was to determine the effect of mycobacterial proteins on mycobacterial biofilm formation and growth processes. We separated growth-affecting proteins (GEPs) from wild type of Mycobacterium bovis and ATCC strain of Mycobacterium avium subsp. avium. Our results showed that these mycobacteria-secreted GEPs are involved in biofilm formation, growth stimulatory, and inhibitory processes. Our findings suggest that GEP stimulated M. avium subsp. avium growth in vitro. Stimulation process was observed in mycobacteria affected with GEP extracted from M...
August 1, 2018: Acta Microbiologica et Immunologica Hungarica
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