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Pathophysiology: the Official Journal of the International Society for Pathophysiology

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https://www.readbyqxmd.com/read/29764719/potential-use-of-bitter-melon-momordica-charantia-derived-compounds-as-antidiabetics-in-silico-and-in-vivo-studies
#1
Olusola Olalekan Elekofehinti, Esther Opeyemi Ariyo, Moses Orimoloye Akinjiyan, Olanrewaju Sam Olayeriju, Akeem Olalekan Lawal, Isaac Gbadura Adanlawo, Joao Batista Teixeira Rocha
Momordica charantia (bitter lemon) belongs to the cucurbitaceae family which has been extensively used in traditional medicines for the cure of various ailments such as cancer and diabetes. The underlying mechanism of M. charantia to maintain glycemic control was investigated. GLP-1 and DPP-4 gene modulation by M. charantia (5-20% inclusion in rats diet) was investigated in vivo by RT-PCR and possible compounds responsible for diabetic action predicted through in silico approach. Phytochemicalss previously characterized from M...
May 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29739640/mimosa-pudica-protects-the-testes-against-cadmium-induced-inflammation-and-oligospermia-potential-benefits-in-treatment-of-heavy-metal-toxicity
#2
F M Onyije, M C Nwanze, G O Alade, T O Alade, O O Mgbere, C K Okpora
Cadmium is a known environmental and industrial pollutant with an enormous tissue disrupting potential. Mimosa pudica (M. pudica) is a creeping annual or perennial herb known to possess anti asthmatic, anti-epileptic, anti-tumour, anti-fertility, aphrodisiac, analgesic, anti-depressant, sedative, emetic properties and a strong radical scavenging activity. This research was aimed at investigating the ameliorative effects of M. pudica on cadmium-induced testicular damage in adult male Sprague Dawley rats. Twenty adult Sprague Dawley rats were employed in the study...
April 27, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29730092/kolaviron-protects-the-brain-in-cuprizone-induced-model-of-experimental-multiple-sclerosis-via-enhancement-of-intrinsic-antioxidant-mechanisms-possible-therapeutic-applications
#3
Gabriel Olaiya Omotoso, Ileje Inelo Ukwubile, Leviticus Arietarhire, Fatima Sulaimon, Ismail Temitayo Gbadamosi
Multiple sclerosis is a demyelinating condition of the central nervous system which commonly affects young adults. Kolaviron, a biflavonoid isolate of Garcinia kola, has been used in experimental studies which explored its anti-oxidative, anti-inflammatory and anti-genotoxic properties. This work was aimed at unraveling the possible ameliorative effect of kolaviron on cuprizone-induced demyelination in the prefrontal cortices of Wistar rats. A total of 28 adult male Wistar rats were divided into four groups A-D...
April 27, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29685587/the-pathophysiology-of-myocardial-infarction-induced-heart-failure
#4
REVIEW
Daniele Gabriel-Costa
Heart failure (HF) is a multifactorial disorder and is usually the end stage of many cardiovascular diseases (CVD). HF presents one of the highest morbidity and mortality indices worldwide and high costs to public health organizations. Myocardial infarction (MI) is the most prevalent CVD in the Western world and leads to HF when its management is inadequate. It has a destructive potential for heart cells and abruptly reduces the cardiac output, a clinical condition known as heart dysfunction that might progress to HF...
April 18, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29673924/food-additives-food-and-the-concept-of-food-addiction-is-stimulation-of-the-brain-reward-circuit-by-food-sufficient-to-trigger-addiction
#5
REVIEW
A Y Onaolapo, O J Onaolapo
In the last few years, the concept of 'food addiction' has continued to gain popularity, with human and animal studies demonstrating the differential effects of foods that are high in fat, sugar or protein on appetite, satiety, eating behaviour and the development of food addiction. However, a number of studies have disputed the occurrence of food addiction in humans. Questions have also arisen regarding the possible impacts that food additives may have on the development of food addiction or eating disorders...
April 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29678356/attenuation-of-cytotoxicity-induced-by-tbhp-in-h9c2-cells-by-bacopa-monniera-and-bacoside-a
#6
Mohan Manu T, T Anand, Farhath Khanum
Cardiovascular diseases are one of the major global health issues leading to morbidity and mortality across the world. In the present study Bacopa monniera and its major bioactive component, Bacoside A (Bac-A) was used to evaluate its cytoprotective property in H9C2 cardiomyocytes against tBHP (150 μM) induced ROS-mediated oxidative stress and apoptosis. Our results implicate that pre-treatment with hydroalcoholic extract of Bacopa monniera (BME) and Bac-A (125 μg/ml and 6 μg/ml respectively) significantly restored oxidative stress by scavenging the free radicals and also elevated phase II antioxidant defensive enzymes such as (SOD, CAT, GR, GPx and GSH)...
April 11, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29636289/folic-acid-protects-against-experimental-prenatal-nicotine-induced-cardiac-injury-by-decreasing-inflammatory-changes-serum-tnf-and-cox-2-expression
#7
Marwa A Ahmed, Heba M Kamal, Ahmed M Taha, Shimaa F Abd-Allateef
Nicotine administration has been shown to increase the risk for cardiovascular diseases and death. The present study was designed to investigate the impact of nicotine administration on serum level tumor necrosis factor and cycloxygenase -2 (COX-2) expression mediated cardiac injury in rat off springs, and the possible protective effect of folic acid. Eighteen pregnant female rats were randomly divided into three groups, six animals each. Control group received the vehicle, nicotine group received a dose of nicotine 0...
April 5, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29580677/consomic-rats-parental-strains-differ-in-sensory-perception-pain-developed-following-nerve-injury-and-in-il-1-beta-and-il-6-levels
#8
Andrew Young, Mythili Kalladka, Archana Viswanath, Tal Zusman, Junad Khan
No abstract text is available yet for this article.
March 19, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29628185/revisiting-colorectal-cancer-animal-model-an-improved-metastatic-model-for-distal-rectosigmoid-colon-carcinoma
#9
Rui Caetano-Oliveira, Marcos António Gomes, Ana Margarida Abrantes, Edgar Tavares-Silva, Marco Carvalho Oliveira, Mafalda Laranjo, Débora Basílio Queirós, João Casalta-Lopes, Salomé Pires, Lina Carvalho, Rosa Gouveia, Paulo Rodrigues Santos, Denise Gonçalves Priolli, José Guilherme Tralhão, Maria Filomena Botelho
Colorectal cancer (CRC) is the second most frequent and fatal cancer in Western countries. Understanding its biology with different incidence along the colon and rectum, genetic profile and how these factors contribute to local/distant progression, has been hampered by the lack of a suitable CRC model. We report a reproducible model, using human CRC cell lines (CL) (WiDr, LS1034, C2BBe1) injected (1 × 107 cells/animal) in RNU rats (n = 55) which underwent cecostomy and descending colostomy with mucosal-cutaneous fistula of the sigmoid colon...
March 13, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29510888/prediction-of-first-trimester-preeclampsia-relevance-of-the-oxidative-stress-marker-mda-in-a-combination-model-with-pp-13-papp-a-and-beta-hcg
#10
Burak Asiltas, Esma Surmen-Gur, Gurkan Uncu
OBJECTIVE: Early diagnosis of preeclampsia (PE) is very important and various parameters, individually or in combined models, are reported useful for prediction of PE. The objective of this study is to investigate the predictive value of pregnancy-associated plasma protein-A (PAPP-A), placental protein-13 (PP-13), human Chorionic Gonadotropin (B-HCG), and oxidative stress marker malondialdehyde (MDA), individually and in combination. MATERIALS AND METHODS: Maternal sera of 38 cases with PE and 122 controls were collected for first trimester screening and tested for PAPP-A and B-HCG by chemiluminescence, for PP-13 by using ELISA, and for MDA by high-performance liquid chromatography...
February 27, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29395794/folate-receptor-%C3%AE-is-associated-with-poor-clinicopathological-perspectives-in-breast-carcinoma
#11
Noha Abd ElRahim Aboulhagag, Rana Fathy Torky, Sabah Ahmed Fadel
BACKGROUND: Breast carcinoma is the commonest malignancy in females. Folate is required for the biosynthesis of nucleotide bases, amino acids, and other cellular methylation reactions in proteins and phospholipids. The high affinity folate receptor alpha (FRα) has been shown to be expressed in several kinds of human cancers. METHODS: In this descriptive-analytic study, sections from formalin-fixed paraffin-embedded tissue blocks of 50 cases of invasive ductal breast carcinoma (IDC) as well as 15 cases of non-neoplastic breast specimens were immunohistochemically stained with FRα antibody...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29307662/moringa-oleifera-phytochemicals-protect-the-brain-against-experimental-nicotine-induced-neurobehavioral-disturbances-and-cerebellar-degeneration
#12
Gabriel Olaiya Omotoso, Ismail Temitayo Gbadamosi, Olayemi Joseph Olajide, Shakirat Opeyemi Dada-Habeeb, Tolulope Timothy Arogundade, Emmanuel Olusola Yawson
Nicotine is a neuro-stimulant that has been implicated in the pathophysiology of many brain diseases. The need to prevent or alleviate the resulting dysfunction is therefore paramount, which has also given way to the use of medicinal plants in the management of brain conditions. This study was designed to determine the histomorphological and neurobehavioural changes in the cerebellum of Wistar rats following nicotine insult and how such injuries respond to Moringa intervention. Twenty-four adult male Wistar rats were divided into 4 groups...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29306510/protective-effects-of-artemisia-campestris-extract-against-gastric-acid-reflux-induced-esophageal-mucosa-injuries
#13
Mohamed-Amine Jabri, Haifa Tounsi, Afifa Abdellaoui, Lamjed Marzouki, Hichem Sebai
Artemisia campestris L. has been widely used in alternative medicine to treat digestive system diseases, particularly gastroesophageal disorders. In the present investigation, we studied the putative protective effect of Artemisia campestris aqueous extract (ACAE) against gastro-esophageal reflux (GER)-induced esophagitis in rats. The experimental ophagitis was induced by the ligation of the pylorus as well as the junction between the forestomach and the corpus. We firstly found that ACAE administration at 100, 200 and 400 mg/kg, b...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29274871/glucocorticoid-receptor-activation-selectively-influence-performance-of-wistar-rats-in-y-maze
#14
Amin Abdulbasit, Fii Stephen Michael, Amusa Shukurat Onaopemipo, Alli-Oluwafuyi Abdulmusawwir, Imam Aminu, Asogwa Nnaemeka Tobechukwu, Abdulmajeed Wahab Imam, Adeyanju Oluwaseun Aremu, Olaseinde Folajimi, Abolarinwa Bilikis Aderonke, Ibrahim Ridwan Babatunde, Owoyele Victor Bamidele
Glucocorticoid receptors (GR) are ubiquitously expressed in metazoans. Different and contrasting phenotypes have been reported upon their activation. This study investigated the behavioral phenotypes characteristic of GR stimulation in male Wistar rats. Rats in each of the four groups of rats received one of the following treatments: distilled water (control) or one of three doses of dexamethasone (treatment) injected intraperitoneally for 7 days. The Rats were afterwards subjected to the Y maze, the elevated plus maze (EPM), the Morris water maze (MWM), and the novel object recognition (NOR) test...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29269193/low-cd4-cells-and-viral-co-infection-increase-the-risk-of-vain-use-of-scca1-and-ki67-as-diagno-prognostic-biomarkers
#15
Jude Ogechukwu Okoye, Charles Erinle, Antony Ajuluchukwu Ngokere, Abimbola Jimoh
This study evaluated the correlation of SCCA1, Ki67 and CD4 cell expressions and classified vaginal smears in individuals co-infected with Human immunodeficiency virus (HIV), Herpes simplex virus 2 (HSV2), Epstein Barr virus (EBV) and Human Papilloma virus (HPV). This crossectional study included 173 participants within the age range of 20-70 years. Vaginal smears were stained by Papanicolaou technique and classified into high-grade squamous cell intraepithelial lesion (HSIL), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells of undetermined significance (ASCUS) and negative for intraepithelial lesion (NIL)...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29217084/oral-phenytoin-protects-against-experimental-cyclophosphamide-chemotherapy-induced-hair-loss
#16
A Y Onaolapo, A A Adebayo, O J Onaolapo
In the current study, effects of oral phenytoin on hair growth in cyclophosphamide-treated rats were assessed with the goal of evaluating the ability of phenytoin to suppress chemotherapy-induced hair loss. Thirty-six rats were randomly assigned to six groups (1k6) of six each (n=6). In all groups, anagen was induced in flank skin of rats by depilation. On day 9 (anagen VI), rats were injected once with either distilled water (groups 1-3) or cyclophoshamide (groups 4-6). From day 10, rats in group 1 and 4 received oral vehicle (distilled water), groups 2 and 5 received oral phenytoin (50mg/kg), while groups 3 and 6 also received oral phenytoin (100mg/kg)...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29153770/rats-exposed-to-2-45ghz-of-non-ionizing-radiation-exhibit-behavioral-changes-with-increased-brain-expression-of-apoptotic-caspase-3
#17
Rini Varghese, Anuradha Majumdar, Girish Kumar, Amit Shukla
In recent years there has been a tremendous increase in use of Wi-Fi devices along with mobile phones, globally. Wi-Fi devices make use of 2.4GHz frequency. The present study evaluated the impact of 2.45GHz radiation exposure for 4h/day for 45days on behavioral and oxidative stress parameters in female Sprague Dawley rats. Behavioral tests of anxiety, learning and memory were started from day 38. Oxidative stress parameters were estimated in brain homogenates after sacrificing the rats on day 45. In morris water maze, elevated plus maze and light dark box test, the 2...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29033135/one-year-recombinant-growth-hormone-therapy-does-not-improve-hemoglobin-state-and-morphology-of-erythrocytes-in-growth-hormone-deficient-children
#18
Maria Pankratova, Alexander Yusipovich, Maria Vorontsova, Evgenia Parshina, Svetlana Bochkareva, Alexander Cherkashin, Adil Baizhumanov, Margarita Silicheva, Tatyana Shiryaeva, Georgy Maksimov, Valentina Peterkova
An increase in growth rates of children suffering from growth hormone deficiency (GHD) subjected to recombinant growth hormone treatment (rGHT) was shown to be accompanied by acceleration of metabolic processes that may stimulate oxygen consumption in various organs and tissues. Therefore, oxygen-transporting properties of RBC should undergo considerable changes during the rGHT. The aim of this study was to examine the effects of rGHT on erythrocyte shape and hemoglobin state in GHD children. The level of oxyhemoglobin (Oxy-Hb) in RBC was analyzed by Raman spectroscopy...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28943113/gastroesophageal-reflux-disease-a-clinical-overview-for-primary-care-physicians
#19
REVIEW
Sudha Pandit, Moheb Boktor, Jonathan S Alexander, Felix Becker, James Morris
OBJECTIVE: GERD is among the most common outpatient disease processes encountered by clinicians on a daily basis. This review provides insights about how to approach GERD in terms of disease management and treatment. METHODS: Review articles were searched using PUBMED and MEDLINE using criteria that included English language articles published in the last 5 years concerning studies carried out only in humans. The key words used in the searches were GERD, PPI, and erosive esophagitis...
March 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29500146/n-acetylcysteine-supplementation-decreased-brain-lipid-and-protein-oxidations-produced-by-experimental-homocysteine-thiolactone-exposure-relevance-to-neurodegeneration
#20
A Fatih Aydın, Gamze Kondakçı, Songül Hatipoğlu, Semra Doğru-Abbasoğlu, Müjdat Uysal
High levels of homocysteine (Hcy) have neurotoxic effects. Homocysteine thiolactone (HcyT), a thioester of Hcy, plays a role in Hcy-induced toxicity. In this study, effects of HcyT treatment (500 mg/kg body weight/day in drinking water) for 6 weeks on serum Hcy levels and brain prooxidant-antioxidant balance were investigated in rats. The effect of N-acetylcysteine (NAC) treatment (1 g/kg body weight/day in chow) for 6 weeks on HcyT-induced neurotoxicity was evaluated. Reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), diene conjugate (DC), protein carbonyl (PC) and advanced oxidation protein products (AOPP) were determined in the brain tissue...
February 21, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
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