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Pathophysiology: the Official Journal of the International Society for Pathophysiology

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https://www.readbyqxmd.com/read/30401578/hepatotoxic-effects-of-euphol-rich-fractions-from-euphorbia-bivonae-relevance-to-cytotoxic-and-anti-tumor-activities
#1
Khaled Athmouni, Abdelfattah El Feki, Habib Ayadi
These studies were designed to evaluate the preliminary oral toxicity profile of the crude ethanolic aerial part extract of E. bivonae in the Male albino Wistar rats and its active chemical constituents. The 24-h LD50 was determined using probit analysis method. The single dose LD50 was found to be 2568.64 mg/kg bw when administrated orally in mice. Additionally, the Wistar rats were used to evaluate the subchronic toxicity of E. bivonae ethanolic extract. The serum biomarkers, lipid peroxidation and antioxidants status in liver and histopathological analysis were investigated in normal and treated groups...
November 1, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30413288/jobelyn%C3%A2-ameliorates-neurological-deficits-in-rats-with-ischemic-stroke-through-inhibition-of-release-of-pro-inflammatory-cytokines-and-nf-%C3%AE%C2%BAb-signaling-pathway
#2
Solomon Umukoro, Ejiroghene E Oghwere, Benneth Ben-Azu, Olatunde Owoeye, Abayomi M Ajayi, Osarume Omorogbe, Olajuwon Okubena
The effects of Jobelyn® (JB) on neurological deficits and biochemical alterations associated with ischemic stroke induced by bilateral common carotid artery occlusion (BCCAO) in rats were investigated in this study. Male Wistar rats were divided into five groups (n = 8): group 1 served as Sham control; group 2, which served as negative control received normal saline while groups 3-5 were given JB (25, 50 and 100 mg/kg, p.o) daily for 28 days. Then, rats in groups 2-5 were subjected to BCCAO for 30 min and reperfusion afterwards...
October 28, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30391101/tetracarpidium-conophorum-m%C3%A3-ll-arg-modulates-sexual-behaviour-and-biochemical-parameters-relevant-to-sexual-function-in-male-wistar-rats
#3
Ayodeji Augustine Olabiyi, Ganiyu Oboh, Azeez Olakunle Ishola, Philip Adeyemi Adeniyi, Aline Augusti Boligon
Walnut (Tetracarpidium conophorum Müll. Arg) has been reported to be an essential ingredient in folklore medicine for sexual enhancement with little scientific validation. Hence, this study investigated the effects of walnut supplemented diet on sexual behaviour and biochemical parameters relevant to erection in male Wistar rats. Forty animals used in this study were divided into five groups (n = 8); Group 1 - normal control rats fed with basal diet, Group II - rats fed diet supplemented with 10% processed walnut, Group III - rats fed diet supplemented with 10% raw walnut, Group IV - rats fed diet supplemented with 20% processed walnut and Group V - rats fed diet supplemented with 20% raw walnut...
October 28, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30309759/coconut-oil-protects-against-light-induced-retina-degeneration-in-male-wistar-rats
#4
Bamidele Victor Owoyele, Opeyemi Gideon Ayilara
The retinoprotective effect of Cocos nucifera oil (CNO) was investigated. Twenty male Wistar rats weighing 140 g and 180 g were randomly divided into four groups comprising of five animals each. The control group received distilled water. Retinal degeneration was induced in the remaining three groups by exposing the animals to 5,000 lux of bright white light for two hours. Prior to the light exposure, the light model group (LMG) received distilled water for 14 days, low Cocos nucifera oil (LCNO) group received 5 ml/kg of CNO for 14 days, and the high Cocos nucifera oil (HCNO) group received 10 ml/kg of CNO for 14 days...
October 5, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30293777/interventricular-vessel-of-the-heart-and-myocardial-infarction-induced-heart-failure
#5
Pekka J Kuusela
No abstract text is available yet for this article.
September 22, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30244824/does-loss-of-hormonal-receptors-influence-the-pathophysiological-characteristics-of-the-her-2-breast-cancer-phenotype
#6
Rabab Ahmed Ahmed Mohammed, Moustafa EzEldien M Radwan, Bashayer Marzoog Alrufayi, Linah Abdulsamad Qari Abdulaziz
BACKGROUND: Some breast carcinomas (BC) of the HER-2 type respond poorly to endocrine therapy, indicating that hormonal receptor (HR) status possibly impacts the biological criteria of this tumor class. The aim of this study was to compare the clinicopathological characteristics of HR-positive and HR-negative tumors occurring in HER-2 and non-HER-2 BC. METHODS: Tissue microarray sections from 336 primary invasive BC specimens were stained immunohistochemically with antibodies against HER-2, ER, and PR...
September 16, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30224102/expression-of-thioredoxin-and-glutaredoxin-in-experimental-hepatocellular-carcinoma-relevance-for-prognostic-and-diagnostic-evaluation
#7
Nabil M Abdel-Hamid, Tarek K Mahmoud, Shimaa A Abass, Mamdouh M El-Shishtawy
Hepatocellular carcinoma (HCC), represents more than 85% of liver cancers. The diagnosis of HCC may be delayed due to the absence of early, sensitive and specific biomarkers. This study was conducted to investigate whether the expression of thioredoxin (Trx) and glutaredoxin (Grx) is helpful for HCC diagnosis in an experimental model. Twenty male albino rats were equally divided into two groups (HCC and control). Hepatocarcinogenesis was performed by single intraperitoneal (i.p) injection of 200 mg/kg of diethylnitrosamine (DENA)...
September 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30193790/the-relationship-between-the-neck-circumference-and-the-carotid-intima-media-thickness-in-amerindians-potential-links-to-health-risks
#8
Oscar H Del Brutto, Robertino M Mera, Juan A Nader, Mauricio Zambrano, Pablo R Castillo, Gautam Matcha, Leslie V Simon
The carotid intima media thickness (cIMT) is a predictor of cardiovascular events. The neck circumference (NC) has been investigated as a risk factor for increased cIMT with contradictory results. This study assessed the relationship between NC and cIMT in Atahualpa residents aged ≥40 years who had sonographic examination of carotid arteries (n = 590). We also discussed on potential pathogenetic mechanisms underlying this association. Participants belonged to the Native Ecuadorian (Amerindians) ethnic group...
September 1, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30243460/peripheral-brain-derived-neurotrophic-factor-is-reduced-in-stroke-survivors-with-cognitive-impairment
#9
Tasneem M Hassan, Isyaku U Yarube
Stroke presents a huge burden both globally and locally. Very few studies have evaluated cognitive impairment following stroke in Africa. This study evaluated cognitive impairment in stroke survivors and examined its relationship with peripheral blood levels of brain-derived neurotrophic factor (BDNF). It is hypothesized that serum BDNF levels significantly correlate with cognitive impairment. Cognition was assessed in 47 stroke survivors and 35 normal subjects using the Mini Mental State Examination (MMSE)...
August 31, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30197294/pentoxifylline-protects-against-loss-of-function-and-renal-interstitial-fibrosis-in-chronic-experimental-partial-ureteral-obstruction
#10
Hongbao Ma, Steven Lee, Yan Yang, Puneet Bedi, Shyan-Yih Chou
Tubulointerstitial fibrosis (TIF) is a hallmark of chronic kidney disease resulting from diverse etiologies and predicts severity and progression of the kidney disease. To investigate the pathogenesis of TIF, complete unilateral ureteral obstruction (UUO) is the most widely used animal model. However, UUO precludes evaluation of renal function. In the present study, we created a rat model of chronic partial ureteral obstruction (PUO), which allowed assessment of renal function at different intervals after obstruction...
August 23, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30190096/resveratrol-increases-serum-adiponectin-level-and-decreases-leptin-and-insulin-level-in-an-experimental-model-of-hypercholesterolemia
#11
A Jimoh, Y Tanko, J O Ayo, A Ahmed, A Mohammed
Serum adiponectin concentration is inversely associated with leptin and insulin concentration. There is little paucity of information in the literature on the adipokine levels and regulation by resveratrol in cholesterol diet-fed animals. Thirty rabbits were randomly divided into six groups, each of five animals: Group 1 = control (C), Group 2 = cholesterol diet (CD) only, Group 3 = resveratrol 200 mg/kg (R200), Group 4 = resveratrol 400 mg/kg (R400), Group 5 = CD + R200, Group 6 = CD + R400. The preparations were administered for 8th weeks of the treatment protocol...
August 23, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30126738/preface
#12
EDITORIAL
Olga Pechanova
No abstract text is available yet for this article.
September 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30115542/human-apolipoprotein-a-i-gly26arg-stimulation-of-inflammatory-responses-via-nf-kb-activation-potential-roles-in-amyloidosis
#13
Nahuel A Ramella, Isabel Andújar, José L Ríos, Silvana A Rosú, M Alejandra Tricerri, Guillermo R Schinella
The cascade of molecular events leading to Human apolipoprotein A-I (apoA-I) amyloidosis is not completely understood, not even the pathways that determine clinical manifestations associated to systemic protein deposition in organs such as liver, kidney and heart. About twenty natural variants of apoA-I were described as inducing amyloidosis, but the mechanisms driving their aggregation and deposition are still unclear. We previously identified that the mutant Gly26Arg but not Lys107-0 induced the release of cytokines and reactive oxygen species from cultured RAW 264...
August 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30119970/l-arginine-attenuates-blood-pressure-and-reverses-the-suppression-of-angiogenic-risk-factors-in-a-rat-model-of-preeclampsia
#14
G O Oludare, H D Jinadu, O O Aro
This study investigated the effect of L-arginine on blood pressure, angiogenic factors and liver enzymes in pregnant rats administered L-NAME. Thirty-six female Sprague-Dawley rats weighing between 150-170 g were divided into 4 groups of the control (normal saline), L-NAME (50 mg/kg b.w. intraperitoneal injection from days 13-18 of pregnancy), L-NAME + L-arginine (50 mg/kg b.w. and 1 g/kg b.w of L-arginine from days 13 to 18) and L-arginine (1 g/kg b.w administered orally from days 13 to 18). Urine samples were collected on day 18 of pregnancy and the animals were sacrificed on day 19 of pregnancy for blood pressure parameters, angiogenic and liver enzyme assays...
August 7, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30032909/studies-on-biofilm-formation-and-virulence-factors-associated-with-uropathogenic-escherichia-coli-isolated-from-patient-with-acute-pyelonephritis
#15
A Vysakh, Sebastian Jose Midhun, Kuriakose Jayesh, Mathew Jyothis, M S Latha
The current study aims to the detection of pathogenic potential and virulence factor identification of uropathogenic Escherichia coli BRL-17 isolated from patients urine. The organism was isolated from the patient with chronic pyelonephritis. The identification of organism was done by analyzing gram staining, biochemical, 16S rDNA analysis, Raman microscopy and SEM analysis. The pathogenic potential was identified by multiplex PCR analysis of virulence factor genes like sfa, hly D, pap C. The biofilm forming ability was tested by congo red agar assay and tissue culture plate assay...
July 19, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30017743/resveratrol-prevents-high-fat-diet-induced-obesity-and-oxidative-stress-in-rabbits
#16
A Jimoh, Y Tanko, A Ahmed, A Mohammed, J O Ayo
The rapid epidemiological progression of obesity worldwide has been associated with increased consumption of diets, rich in fat and sugar. Mediterranean diets rich in resveratrol are associated with reduced risk of obesity and oxidative stress. The aim of the experiment was to investigate the protective effect of resveratrol on high fat diet (HFD) induced obesity and oxidative stress changes in rabbits. Thirty rabbits divided into six groups of five animals each were used for the experiment: Group 1 = control (C), Group 2 = high fat diet (HFD) only, Group 3 = resveratrol 200 mg/kg (R200), Group 4 = resveratrol 400 mg/kg (R400), Group 5 = HFD + R200 and group 6 = HFD + R400...
July 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30017742/catechin-quercetin-and-taxifolin-improve-redox-and-biochemical-imbalances-in-rotenone-induced-hepatocellular-dysfunction-relevance-for-therapy-in-pesticide-induced-liver-toxicity
#17
Afolabi C Akinmoladun, Comfort Odunayo Oladejo, Sunday Solomon Josiah, Courage Dele Famusiwa, Olubukola Benedicta Ojo, M Tolulope Olaleye
Hepatotoxicity occurs as a result of adverse effects of some xenobiotics on the liver, which is often the target tissue of toxicity for environmental chemicals. Rotenone, used as a natural pesticide, is an environmental poison reported to cause organ toxicity. This study investigated the protective effect of three flavonoids, catechin, quercetin and taxifolin (2,3-Dihydroquercetin) in rotenone-induced hepatotoxicity. Male Wistar rats were administered rotenone for 10 days followed by post treatment with catechin (5, 10 and 20 mg/kg), quercetin (5, 10 and 20 mg/kg) or taxifolin (0...
July 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30030016/heart-remodeling-produced-by-aortic-stenosis-promotes-cardiomyocyte-apoptosis-mediated-by-collagen-v-imbalance
#18
Paula Grippa Sant'Ana, Sabrina Setembre Batah, Patrícia Santos Leão, Walcy Rosolia Teodoro, Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Danielle Fernandes Vileigas, Vitor Loureiro da Silva, Dijon Henrique Salomé de Campos, Katashi Okoshi, Vera Luiza Capelozzi, Antonio Carlos Cicogna, Alexandre Todorovic Fabro
Cardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related to changes in both myocyte and extracellular matrix (ECM). We investigated that the imbalance of collagen V promotes cardiomyocyte apoptosis that contributes to heart failure and cell death. Aortic stenosis was induced surgically and male Wistar rats were randomized to 18 weeks (Sham 18 w, n = 12; AoS 18 w, n = 12) and severe of heart failure (Sham HF, n = 12; AoS HF, n = 12) groups. Functional and structural echocardiogram, immunohistochemistry for Ki-67, TUNEL assay and Immunofluorescence for collagen were performed...
July 8, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29921483/melatonin-attenuates-chronic-immobilization-stress-induced-muscle-atrophy-in-rats-influence-on-lactate-to-pyruvate-ratios-and-na-k-atpase-activity
#19
Eman S H Abd Allah, Ahmed M Mahmoud
This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobilization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90 min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA levels. An increase in the serum lactate-to-pyruvate ratio and the oxidative stress accompanied by a reduction of Na+ /K+ ATPase activity could be responsible for these changes...
June 16, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29960833/royal-jelly-supplementation-reduces-skeletal-muscle-lipotoxicity-and-insulin-resistance-in-aged-obese-rats
#20
Samah E L Metwally Ibrahim, Ayman Ahmed Kosba
BACKGROUND: Consumption of a high-fat diet (HFD) in aged rats is associated with several metabolic disorders. The mechanism of skeletal muscle lipotoxicity and insulin resistance (IR) is multi-factorial, but the exact mechanism of how aging affects these processes unknown. Royal jelly (RJ) is a dietary supplement with many physiological and pharmacological properties. No previous studies have demonstrated the protective effects and mechanism of RJ in aged obese rats. OBJECTIVES: The study was carried to investigate the effects of aging and HFD on skeletal muscles, and adipose tissue metabolism and inflammation, in aged rats, and whether RJ could combat such adverse effects...
June 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
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