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Pathophysiology: the Official Journal of the International Society for Pathophysiology

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https://www.readbyqxmd.com/read/30224102/expression-of-thioredoxin-and-glutaredoxin-in-experimental-hepatocellular-carcinoma-relevance-for-prognostic-and-diagnostic-evaluation
#1
Nabil M Abdel-Hamid, Tarek K Mahmoud, Shimaa A Abass, Mamdouh M El-Shishtawy
Hepatocellular carcinoma (HCC), represents more than 85% of liver cancers. The diagnosis of HCC may be delayed due to the absence of early, sensitive and specific biomarkers. This study was conducted to investigate whether the expression of thioredoxin (Trx) and glutaredoxin (Grx) is helpful for HCC diagnosis in an experimental model. Twenty male albino rats were equally divided into two groups (HCC and control). Hepatocarcinogenesis was performed by single intraperitoneal (i.p) injection of 200 mg/kg of diethylnitrosamine (DENA)...
September 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30193790/the-relationship-between-the-neck-circumference-and-the-carotid-intima-media-thickness-in-amerindians-potential-links-to-health-risks
#2
Oscar H Del Brutto, Robertino M Mera, Juan A Nader, Mauricio Zambrano, Pablo R Castillo, Gautam Matcha, Leslie V Simon
The carotid intima media thickness (cIMT) is a predictor of cardiovascular events. The neck circumference (NC) has been investigated as a risk factor for increased cIMT with contradictory results. This study assessed the relationship between NC and cIMT in Atahualpa residents aged ≥40 years who had sonographic examination of carotid arteries (n = 590). We also discussed on potential pathogenetic mechanisms underlying this association. Participants belonged to the Native Ecuadorian (Amerindians) ethnic group...
September 1, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30197294/pentoxifylline-protects-against-loss-of-function-and-renal-interstitial-fibrosis-in-chronic-experimental-partial-ureteral-obstruction
#3
Hongbao Ma, Steven Lee, Yan Yang, Puneet Bedi, Shyan-Yih Chou
Tubulointerstitial fibrosis (TIF) is a hallmark of chronic kidney disease resulting from diverse etiologies and predicts severity and progression of the kidney disease. To investigate the pathogenesis of TIF, complete unilateral ureteral obstruction (UUO) is the most widely used animal model. However, UUO precludes evaluation of renal function. In the present study, we created a rat model of chronic partial ureteral obstruction (PUO), which allowed assessment of renal function at different intervals after obstruction...
August 23, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30190096/resveratrol-increases-serum-adiponectin-level-and-decreases-leptin-and-insulin-level-in-an-experimental-model-of-hypercholesterolemia
#4
A Jimoh, Y Tanko, J O Ayo, A Ahmed, A Mohammed
Serum adiponectin concentration is inversely associated with leptin and insulin concentration. There is little paucity of information in the literature on the adipokine levels and regulation by resveratrol in cholesterol diet-fed animals. Thirty rabbits were randomly divided into six groups, each of five animals: Group 1 = control (C), Group 2 = cholesterol diet (CD) only, Group 3 = resveratrol 200 mg/kg (R200), Group 4 = resveratrol 400 mg/kg (R400), Group 5 = CD + R200, Group 6 = CD + R400. The preparations were administered for 8th weeks of the treatment protocol...
August 23, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30115542/human-apolipoprotein-a-i-gly26arg-stimulation-of-inflammatory-responses-via-nf-kb-activation-potential-roles-in-amyloidosis
#5
Nahuel A Ramella, Isabel Andújar, José L Ríos, Silvana A Rosú, M Alejandra Tricerri, Guillermo R Schinella
The cascade of molecular events leading to Human apolipoprotein A-I (apoA-I) amyloidosis is not completely understood, not even the pathways that determine clinical manifestations associated to systemic protein deposition in organs such as liver, kidney and heart. About twenty natural variants of apoA-I were described as inducing amyloidosis, but the mechanisms driving their aggregation and deposition are still unclear. We previously identified that the mutant Gly26Arg but not Lys107-0 induced the release of cytokines and reactive oxygen species from cultured RAW 264...
August 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30119970/l-arginine-attenuates-blood-pressure-and-reverses-the-suppression-of-angiogenic-risk-factors-in-a-rat-model-of-preeclampsia
#6
G O Oludare, H D Jinadu, O O Aro
This study investigated the effect of L-arginine on blood pressure, angiogenic factors and liver enzymes in pregnant rats administered L-NAME. Thirty-six female Sprague-Dawley rats weighing between 150-170 g were divided into 4 groups of the control (normal saline), L-NAME (50 mg/kg b.w. intraperitoneal injection from days 13-18 of pregnancy), L-NAME + L-arginine (50 mg/kg b.w. and 1 g/kg b.w of L-arginine from days 13 to 18) and L-arginine (1 g/kg b.w administered orally from days 13 to 18). Urine samples were collected on day 18 of pregnancy and the animals were sacrificed on day 19 of pregnancy for blood pressure parameters, angiogenic and liver enzyme assays...
August 7, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30032909/studies-on-biofilm-formation-and-virulence-factors-associated-with-uropathogenic-escherichia-coli-isolated-from-patient-with-acute-pyelonephritis
#7
A Vysakh, Sebastian Jose Midhun, Kuriakose Jayesh, Mathew Jyothis, M S Latha
The current study aims to the detection of pathogenic potential and virulence factor identification of uropathogenic Escherichia coli BRL-17 isolated from patients urine. The organism was isolated from the patient with chronic pyelonephritis. The identification of organism was done by analyzing gram staining, biochemical, 16S rDNA analysis, Raman microscopy and SEM analysis. The pathogenic potential was identified by multiplex PCR analysis of virulence factor genes like sfa, hly D, pap C. The biofilm forming ability was tested by congo red agar assay and tissue culture plate assay...
July 19, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30017743/resveratrol-prevents-high-fat-diet-induced-obesity-and-oxidative-stress-in-rabbits
#8
A Jimoh, Y Tanko, A Ahmed, A Mohammed, J O Ayo
The rapid epidemiological progression of obesity worldwide has been associated with increased consumption of diets, rich in fat and sugar. Mediterranean diets rich in resveratrol are associated with reduced risk of obesity and oxidative stress. The aim of the experiment was to investigate the protective effect of resveratrol on high fat diet (HFD) induced obesity and oxidative stress changes in rabbits. Thirty rabbits divided into six groups of five animals each were used for the experiment: Group 1 = control (C), Group 2 = high fat diet (HFD) only, Group 3 = resveratrol 200 mg/kg (R200), Group 4 = resveratrol 400 mg/kg (R400), Group 5 = HFD + R200 and group 6 = HFD + R400...
July 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30017742/catechin-quercetin-and-taxifolin-improve-redox-and-biochemical-imbalances-in-rotenone-induced-hepatocellular-dysfunction-relevance-for-therapy-in-pesticide-induced-liver-toxicity
#9
Afolabi C Akinmoladun, Comfort Odunayo Oladejo, Sunday Solomon Josiah, Courage Dele Famusiwa, Olubukola Benedicta Ojo, M Tolulope Olaleye
Hepatotoxicity occurs as a result of adverse effects of some xenobiotics on the liver, which is often the target tissue of toxicity for environmental chemicals. Rotenone, used as a natural pesticide, is an environmental poison reported to cause organ toxicity. This study investigated the protective effect of three flavonoids, catechin, quercetin and taxifolin (2,3-Dihydroquercetin) in rotenone-induced hepatotoxicity. Male Wistar rats were administered rotenone for 10 days followed by post treatment with catechin (5, 10 and 20 mg/kg), quercetin (5, 10 and 20 mg/kg) or taxifolin (0...
July 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30030016/heart-remodeling-produced-by-aortic-stenosis-promotes-cardiomyocyte-apoptosis-mediated-by-collagen-v-imbalance
#10
Paula Grippa Sant'Ana, Sabrina Setembre Batah, Patrícia Santos Leão, Walcy Rosolia Teodoro, Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Danielle Fernandes Vileigas, Vitor Loureiro da Silva, Dijon Henrique Salomé de Campos, Katashi Okoshi, Vera Luiza Capelozzi, Antonio Carlos Cicogna, Alexandre Todorovic Fabro
Cardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related to changes in both myocyte and extracellular matrix (ECM). We investigated that the imbalance of collagen V promotes cardiomyocyte apoptosis that contributes to heart failure and cell death. Aortic stenosis was induced surgically and male Wistar rats were randomized to 18 weeks (Sham 18 w, n = 12; AoS 18 w, n = 12) and severe of heart failure (Sham HF, n = 12; AoS HF, n = 12) groups. Functional and structural echocardiogram, immunohistochemistry for Ki-67, TUNEL assay and Immunofluorescence for collagen were performed...
July 8, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/30126738/preface
#11
EDITORIAL
Olga Pechanova
No abstract text is available yet for this article.
September 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29921483/melatonin-attenuates-chronic-immobilization-stress-induced-muscle-atrophy-in-rats-influence-on-lactate-to-pyruvate-ratios-and-na-k-atpase-activity
#12
Eman S H Abd Allah, Ahmed M Mahmoud
This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobilization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90 min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA levels. An increase in the serum lactate-to-pyruvate ratio and the oxidative stress accompanied by a reduction of Na+ /K+ ATPase activity could be responsible for these changes...
June 16, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29960833/royal-jelly-supplementation-reduces-skeletal-muscle-lipotoxicity-and-insulin-resistance-in-aged-obese-rats
#13
Samah E L Metwally Ibrahim, Ayman Ahmed Kosba
BACKGROUND: Consumption of a high-fat diet (HFD) in aged rats is associated with several metabolic disorders. The mechanism of skeletal muscle lipotoxicity and insulin resistance (IR) is multi-factorial, but the exact mechanism of how aging affects these processes unknown. Royal jelly (RJ) is a dietary supplement with many physiological and pharmacological properties. No previous studies have demonstrated the protective effects and mechanism of RJ in aged obese rats. OBJECTIVES: The study was carried to investigate the effects of aging and HFD on skeletal muscles, and adipose tissue metabolism and inflammation, in aged rats, and whether RJ could combat such adverse effects...
June 12, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29908890/genetic-polymorphism-of-glutathione-s-transferases-relevance-to-neurological-disorders
#14
REVIEW
Sreenivasulu Dasari, Sailaja Gonuguntla, Muni Swamy Ganjayi, Suman Bukke, Basha Sreenivasulu, Balaji Meriga
Glutathione S-tranferases (GSTs) are phase II drug metabolizing enzymes, they play crucial role in detoxification of environmental pollutants, carcinogens, drugs, xenobiotics and oxidative stress products. Genetic differences in expression and activity of GSTs are due to the existence of polymorphic alleles which encode them. Because of genetic polymorphism the GST activity has altered that lead to the increased susceptibility for toxic chemical compounds. GST genetic polymorphism is the main reason for many neurological dysfunctions...
June 11, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29678356/attenuation-of-cytotoxicity-induced-by-tbhp-in-h9c2-cells-by-bacopa-monniera-and-bacoside-a
#15
Mohan Manu T, T Anand, Farhath Khanum
Cardiovascular diseases are one of the major global health issues leading to morbidity and mortality across the world. In the present study Bacopa monniera and its major bioactive component, Bacoside A (Bac-A) was used to evaluate its cytoprotective property in H9C2 cardiomyocytes against tBHP (150 μM) induced ROS-mediated oxidative stress and apoptosis. Our results implicate that pre-treatment with hydroalcoholic extract of Bacopa monniera (BME) and Bac-A (125 μg/ml and 6 μg/ml respectively) significantly restored oxidative stress by scavenging the free radicals and also elevated phase II antioxidant defensive enzymes such as (SOD, CAT, GR, GPx and GSH)...
June 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29636289/folic-acid-protects-against-experimental-prenatal-nicotine-induced-cardiac-injury-by-decreasing-inflammatory-changes-serum-tnf-and-cox-2-expression
#16
Marwa A Ahmed, Heba M Kamal, Ahmed M Taha, Shimaa F Abd-Allateef
Nicotine administration has been shown to increase the risk for cardiovascular diseases and death. The present study was designed to investigate the impact of nicotine administration on serum level tumor necrosis factor and cycloxygenase -2 (COX-2) expression mediated cardiac injury in rat off springs, and the possible protective effect of folic acid. Eighteen pregnant female rats were randomly divided into three groups, six animals each. Control group received the vehicle, nicotine group received a dose of nicotine 0...
June 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29628185/revisiting-colorectal-cancer-animal-model-an-improved-metastatic-model-for-distal-rectosigmoid-colon-carcinoma
#17
Rui Caetano-Oliveira, Marcos António Gomes, Ana Margarida Abrantes, Edgar Tavares-Silva, Marco Carvalho Oliveira, Mafalda Laranjo, Débora Basílio Queirós, João Casalta-Lopes, Salomé Pires, Lina Carvalho, Rosa Gouveia, Paulo Rodrigues Santos, Denise Gonçalves Priolli, José Guilherme Tralhão, Maria Filomena Botelho
Colorectal cancer (CRC) is the second most frequent and fatal cancer in Western countries. Understanding its biology with different incidence along the colon and rectum, genetic profile and how these factors contribute to local/distant progression, has been hampered by the lack of a suitable CRC model. We report a reproducible model, using human CRC cell lines (CL) (WiDr, LS1034, C2BBe1) injected (1 × 107 cells/animal) in RNU rats (n = 55) which underwent cecostomy and descending colostomy with mucosal-cutaneous fistula of the sigmoid colon...
June 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29580677/consomic-rats-parental-strains-differ-in-sensory-perception-pain-developed-following-nerve-injury-and-in-il-1-beta-and-il-6-levels
#18
Andrew Young, Mythili Kalladka, Archana Viswanath, Tal Zusman, Junad Khan
No abstract text is available yet for this article.
June 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29510888/prediction-of-first-trimester-preeclampsia-relevance-of-the-oxidative-stress-marker-mda-in-a-combination-model-with-pp-13-papp-a-and-beta-hcg
#19
Burak Asiltas, Esma Surmen-Gur, Gurkan Uncu
OBJECTIVE: Early diagnosis of preeclampsia (PE) is very important and various parameters, individually or in combined models, are reported useful for prediction of PE. The objective of this study is to investigate the predictive value of pregnancy-associated plasma protein-A (PAPP-A), placental protein-13 (PP-13), human Chorionic Gonadotropin (B-HCG), and oxidative stress marker malondialdehyde (MDA), individually and in combination. MATERIALS AND METHODS: Maternal sera of 38 cases with PE and 122 controls were collected for first trimester screening and tested for PAPP-A and B-HCG by chemiluminescence, for PP-13 by using ELISA, and for MDA by high-performance liquid chromatography...
June 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29501391/increased-glomerular-bax-bcl2-ratio-is-positively-correlated-with-glomerular-sclerosis-in-lupus-nephritis
#20
Ghada Hosny, Wesam Ismail, Rania Makboul, Fatma A M Badary, Thanaa M M Sotouhy
INTRODUCTION: The role of intrinsic pathway of apoptosis in pathogenesis of lupus nephritis (LN) is still not clear. We investigated the relation between the expression of two major proteins of the intrinsic pathway of apoptosis; bcl2 as an antiapoptotic protein and bax as a proapoptotic one; in renal tissue of LN. METHODS: The study included fifty paraffin embedded renal tissue obtained from renal biopsy specimens of LN patients (8 cases class II, 10 cases class III, 21 cases class IV and 11 cases class V) and five paraffin embedded apparently normal renal tissue obtained from nephrectomy specimens due to renal neoplasms as a control group...
June 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
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