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Acta Dermatovenerologica Croatica: ADC

Mikela Petković, Ružica Jurakić Tončić
A new morphological variant of superficial spreading melanoma (SSM) was first described by Kutzner et al. (1) and named "melanoma composed exclusively or predominantly of large nests"; it was later named "nested melanoma" (NM) (2,3). Clinically, lesions are larger in diameter (>6 mm), mostly showing typical clinical features of melanoma (the ABCD rule), and significantly different from all other pigmented lesions (the "ugly duckling sign") (1). The majority of NM is found on the trunk and limbs of patients older than 60 years (1-9)...
April 2017: Acta Dermatovenerologica Croatica: ADC
Katerina Damevska, Gorgi Gocev, Nora Pollozahani, Suzana Nikolovska, Lence Neloska
Beau lines are transverse, band-like depressions extending from one lateral edge of the nail to the other and affecting all nails at corresponding levels (1). Onychomadesis is considered an extreme form of Beau line with subsequent separation of the proximal nail plate from the nail bed. Both fall along a spectrum of nail plate abnormalities that occur secondary to temporary nail matrix arrest (NMA). Various systemic and dermatologic conditions have been reported in association with onychomadesis (2-7) (Table 1)...
April 2017: Acta Dermatovenerologica Croatica: ADC
Tino Klancir, Višnja Nesek Adam, Martina Matolić, Elvira Grizelj Stojčić, Maja Karaman Ilić
Toxic epidermal necrolysis (TEN) is severe cutaneous hypersensitivity reaction characterized by necrosis of the epidermis and detachment of the epidermis and dermis that usually occurs as an idiosyncratic reaction to certain drugs. We report the case of a patient admitted to our Intensive Care Unit after an above-the-knee amputation who developed toxic epidermal necrolysis, possibly resulting from antibiotics therapy. Therapy included a combination of intravenous immunoglobulin with gentle early debridement of necrotic skin areas followed by wound coverage with a synthetic cover (Aquacel Ag®)...
April 2017: Acta Dermatovenerologica Croatica: ADC
Paola Đurinec, Jaka Radoš, Vera Katalinić-Janković, Ines Lakoš Jukić, Krešimir Kostović
M. marinum, a nontuberculous mycobacterium, is a rare human pathogen widely distributed in the aquatic environment. In the previous century, epidemics took place due to inadequately chlorinated swimming pool water. Nowadays the majority of infections are acquired through contact of previously damaged skin with contaminated fish tank water. We present a case of M. marinum infection of the hand in an aquarium hobbyist which stayed unrecognized for 2 years. After confirming the correct diagnosis, the patient was successfully treated with a regiment containing clarithromycin and rifampicin...
April 2017: Acta Dermatovenerologica Croatica: ADC
Rodica Olteanu, Alexandra Zota, Magda Constantin
Biosimilars represent a new trend in the treatment of many immune-mediated inflammatory diseases. Regulatory requirements for approval of biosimilars are different from those of originators and rely mostly on the evidence generated from bioequivalence studies and in particular from RCTs. Our goal in this review was to search for relevant studies from randomized controlled trials on the biosimilars adalimumab, etanercept, infliximab and ustekinumab compared with their reference medication (publication in Medline) and ongoing studies in clinical trial registries...
April 2017: Acta Dermatovenerologica Croatica: ADC
Beata Bergler-Czop, Bartosz Miziołek
Skin aging is a combination of reduction in the biological activity of cells, a slowing down of regenerative processes, and a loss of resistance to environmental factors. Genetics, lifestyle, and hormones significantly affect proper functioning of the skin. The aim of this article was to present the current knowledge about aging processes and concurrent therapies which can influence skin aging.
April 2017: Acta Dermatovenerologica Croatica: ADC
Hamza Yildiz, Zafer Demirer, Ibrahim Ozmen
The aim of this study was to determine the prevalence of pearly penile papules (PPP) among young men in Eskisehir, Turkey. This was a prospective, non-randomized, cross-sectional study. From December 2014 to September 2015, 2613 consecutive male patients who were referred to the dermatology outpatient clinic were included in the study. Patients were inspected for the presence of PPP, localization, and association with human papilloma virus (HPV). A total of 2613 patients were included in the study. The average age of the patients was 21...
April 2017: Acta Dermatovenerologica Croatica: ADC
Luca Roncati, Francesco Piscioli, Teresa Pusiol, Antonio Maiorana
Cutaneous melanoma (M) can develop through two progression phases: the radial growth phase of M (RGPM) and the vertical one. This distinction has a practical relevance in defining lesions with potential for a metastatic course. We analyzed the morphological attributes (intraepidermal proliferation type, inflammatory infiltrate, mitogenicity, Breslow thickness, Clark level, ulceration) and the immunohistochemical profile (S100, Melan A, HMB45, p16INK4a, CD117, Ki67, Cyclin D1, E Cadherin, Podoplanin) of 12 microinvasive RGPMs in absence of regression, with almost 10 years of follow-up...
April 2017: Acta Dermatovenerologica Croatica: ADC
Hrvoje Cvitanović, Mirna Šitum, Jelena Meštrović-Štefekov, Liborija Lugović-Mihić
Stressful life events in response to a psychosocial trigger have been reported to negatively affect the course of infections. This study was based on patients with clinical manifestations of human papillomavirus (HPV) infection and a control group of patients with psoriasis who were admitted over a period of one year to the Dermatology Department of Karlovac General Hospital. A total of 122 patients participated in the study, either with a confirmed diagnosis of clinical manifestations of HPV infection (n=66) or in a psoriasis control group (n=56)...
April 2017: Acta Dermatovenerologica Croatica: ADC
Sibel Doğan, Nilgün Atakan
Psoriasis is a systemic inflammatory disease accepted as an independent risk factor for cardiovascular diseases (CVD). Elevated levels and correlation of red cell distribution width (RDW) with inflammatory markers has recently been shown in studies investigating CVD risk and prognosis in rheumatoid arthritis and ankylosing spondylitis. The aim of this study was to evaluate levels and correlation of RDW with inflammatory markers in patients with plaque psoriasis. Data including demographics, disease severity indices, laboratory parameters, and bioelectrical impedance analysis was collected from medical charts of patients who were diagnosed with plaque psoriasis at the Hacettepe University Department of Dermatology between March 2014 and August 2015...
April 2017: Acta Dermatovenerologica Croatica: ADC
Rafał Białynicki-Birula, Radomir Reszke, Jacek C Szepietowski
Maculopapular cutaneous mastocytosis (MPCM) is a variant of cutaneous mastocytosis resulting from abnormal accumulation of mast cells in dermal tissues. Ultrasonography is a contemporary, safe, non-invasive, and real-time diagnostic method. High-frequency ultrasonography (HFUS) utilizes probes emitting frequencies of 20 MHz and higher, visualizing and measuring areas of healthy and lesional skin in various dermatologic conditions. We examined 4 patients with MPCM using a taberna pro medicumTM (Germany) device...
April 2017: Acta Dermatovenerologica Croatica: ADC
Sevgi Akarsu, Ozlem Ozbagcivan, Turna Ilknur, Fatma Semiz, Banu Lebe, Emel Fetil
Patients with lupus erythematosus (LE) that have discoid lesions who fulfill the four diagnostic criteria of systemic lupus erythematosus (SLE) with only mucocutaneous findings and antinuclear antibody (ANA) positivity were classified as borderline SLE in the literature. Objective of this study was to determine the place of borderline SLE with discoid lesions on the LE spectrum according to the lupus band test (LBT). Lesional and sun-protected non-lesional (SPNL) skin LBTs of 94 patients with LE that had discoid lesions were retrospectively evaluated...
April 2017: Acta Dermatovenerologica Croatica: ADC
Dubravka Živanović, Ljiljana Medenica, Ivan Soldatović, Dušan Popadić
The enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF) have both been used for testing of antibodies to desmogleins 1 and 3 (anti-Dsg1 and anti-Dsg3) and for the serologic diagnosis of pemphigus. IIF values and antibody concentrations and profile do not always correlate with a specific clinical phenotype and with the disease activity. The purpose of the present study was to correlate the clinical phenotype of patients with pemphigus vulgaris (PV) and the disease activity with anti-Dsg1 and anti-Dsg3 antibodies and IIF titers...
April 2017: Acta Dermatovenerologica Croatica: ADC
Goran Benčina, Marija Buljan, Mirna Šitum, Ranko Stevanović, Vanesa Benković
Melanoma incidence is increasing, especially in the younger population. The aim of this study was to investigate the cost of this disease in the Croatian population and to identify costs through types of care and types of costs. The secondary goal was to estimate the prevalence of certain types of melanoma (as well as staging distribution) and to connect each stage and its prevalence in Croatia to related costs. A cost-of-illness analysis was performed, mainly including direct costs (monitoring, drugs, primary health care services, hospitalizations, and diagnostics)...
April 2017: Acta Dermatovenerologica Croatica: ADC
Luca Roncati, Teresa Pusiol, Francesco Piscioli
Today, the scientific community is focusing on the prognostic significance of different histological subtypes of thin melanoma (1). The current staging system for melanoma of the American Joint Committee on Cancer (AJCC) uses Breslow thickness as the primary attribute: melanomas with up to 1 mm thickness is defined as thin, because they present a good prognosis after surgical excision, with a 10-year survival rate of 85-90% in case of a tumor-free margin ≥1 cm (2). There is a significant interaction between mitotic rate and Breslow depth, so the predictive value of the mitotic rate on sentinel lymph node (SLN) positivity can be dependent on Breslow thickness (3)...
December 2016: Acta Dermatovenerologica Croatica: ADC
Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos
Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks...
December 2016: Acta Dermatovenerologica Croatica: ADC
Uwe Wollina
Facial musculature is divided into masticatory muscles, i.e. M. masseter and M. buccalis, with bony insertions and smaller facial muscles involved in facial expression, which insert into bone and skin. There are four fixed osteocutaneous points of the face, i.e. zygomatic (Mac Gregor), mandibular (Furnas), orbital (Psillakis), and masseteric with an antigravitational effect and functional role in facial expression (1,2). In other body parts, the direct insertion of muscle fibers into skin has not been reported...
December 2016: Acta Dermatovenerologica Croatica: ADC
Magdalena Czarnecka-Operacz, Dorota Jenerowicz, Joanna Szulczyńska-Gabor, Ewa Teresiak-Mikołajczak, Joanna Szyfter-Harris, Monika Bowszyc-Dmochowska
Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. This type of cutaneous reaction is associated with inflammation manifesting with erythema, edema, and vesicles...
December 2016: Acta Dermatovenerologica Croatica: ADC
Hanna Przepiera-Będzak, Marek Brzosko
The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Venous thrombosis complicating SAPHO syndrome seems to be uncommon with an unclear pathogenesis (3-9)...
December 2016: Acta Dermatovenerologica Croatica: ADC
Jurr Boer, Dalibor Mihajlovic
Dear Editor, Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease. The primary clinical presentation are painful inflamed nodules or boils of inverse areas, i.e. the axillary and anogenito-crural regions, but it can also involve the infra- and inter-mammary regions (1,2). The etiology of HS is not clearly defined. Obesity, smoking, and genetic factors are considered important risk factors. In addition, it has also been suggested that friction may contribute to the development of HS, especially in the obese, but this is based on highly anecdotal reports (3-5)...
December 2016: Acta Dermatovenerologica Croatica: ADC
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