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Acta Dermatovenerologica Croatica: ADC

Shiang Yu-Yang, Stephen Chu-Sung Hu, Sheng Yiao-Lin
Dear Editor, Bullous pemphigoid (BP), a relatively common autoimmune blistering disease in the elderly, is characterized by large, tense bullae on urticarial, erythematous, or normal skin. However, atypical BP with polymorphic clinical presentations is rarely encountered, leading to misdiagnosis and delayed treatments (1). BP with lesions resembling erythema gyratum repens or figurate erythema has been regarded as a paraneoplastic phenomenon (1). Herein we report a case with erythema annulare centrifugum-like presentation of BP without evidence of underlying malignancy...
October 2017: Acta Dermatovenerologica Croatica: ADC
Ertugrul Kurtoglu
In their article, Potenza et al. evaluated the influence of etanercept therapy on autonomic cardiovascular regulation in young patients with moderate-to-severe psoriasis without cardiovascular risk factors by measuring the time domain and frequency domain heart rate variability (HRV) parameters from 5-minute electrocardiogram (ECG) recordings (1). The authors used low frequency (LF), high frequency (HF) power, and LF/HF ratio as indices of frequency domain HRV and standard deviation of normal-to-normal intervals (SDNN); the mean root square of the sum of the squares of differences between consecutive R-R intervals (RMSSD) was used as the index of time domain HRV...
October 2017: Acta Dermatovenerologica Croatica: ADC
Mohammad Adil, Syed Suhail Amin, Tasleem Arif
Dear Editor, Nicolau's syndrome, also called embolia cutis medicamentosa or livedoid dermatitis, is a rare injection site reaction characterized by immediate intense pain at the injection site followed by erythema and a hemorrhagic patch with a livedoid reticular pattern after injections of non-steroidal anti-inflammatory drugs (NSAIDS), antiepileptics, antibiotics, antihistaminics, corticosteroids, etc. (1). To the best of our knowledge, only one case of Nicolau's syndrome has been reported after the use of triamcinolone acetonide...
October 2017: Acta Dermatovenerologica Croatica: ADC
Jaka Radoš, Sandra Jerković Gulin, Snježana Dotlić, Sandra Bašić Kinda, Romana Čeović
Dear Editor, the association between lymphomas and autoimmune manifestations, as well as the prevalence of the cases of coexistent lymphomas and autoimmune conditions, has not been completely established (1-3). Since cutaneous T-cell lymphoma (CTCL) cases are rare, any hypothesis can only be based on case reports or small case series. We present the case of a male patient with folliculotropic mycosis fungoides (FMF) and synchronous autoimmune hepatitis (AIH) with extremely high levels of cancer antigen 19-9 (CA 19-9)...
October 2017: Acta Dermatovenerologica Croatica: ADC
Eftychia Platsidaki, Evgenia Balamoti, Anargyros Kouris, Alexandra Katsarou, Nikolaos Mylonakis, Charitomeni Vavouli, Georgios Kontochristopoulos
Bevacizumab is a humanized monoclonal antibody against vascular endothelial factor (VEGF) that targets tumor cell angiogenesis and proliferation. Although it is usually well tolerated, many side-effects have been reported. These include hypertension, bleeding, and thromboembolic events among others. Drug-associated cutaneous adverse effects are less common and include itching, exfoliative dermatitis, and acneiform eruptions. A man with bevacizumab-associated monomorphic skin eruption successfully was treated with 30% salicylic acid peels...
October 2017: Acta Dermatovenerologica Croatica: ADC
Giuseppe Mancuso
Long-lasting allergic patch test reactions (LLAPTR) are those in which the clinical features of palpable erythema are still present at the site of a positive allergic patch test reaction 14 or more days after application of the allergen. LLAPTR have been described for a wide range of contact allergens, many of these included in the baseline patch test series. LLAPTR are far from uncommon; they occur in consecutive patients with positive patch tests to baseline allergens with frequency up to 17.9% of the total reactions...
October 2017: Acta Dermatovenerologica Croatica: ADC
Cindy Wassef, Anacristina Laureano, Robert A Schwartz
Aquagenic urticaria (AQ) is a rare physical urticaria induced by contact with water. It may be distinctive clinically, evident as 1-2 mm folliculopapular urticaria, a pattern also characteristic of cholinergic urticaria. AQ has a truncal and upper extremity distribution within 20-30 minutes after contact with water, regardless of its temperature or source. AQ is usually symptomatic with mild to severe pruritus and a burning sensation. The mechanism by which water produces mast cell degranulation and histamine release remains unclear...
October 2017: Acta Dermatovenerologica Croatica: ADC
Oguzhan Kocak, Aslihan Yonca Kocak, Bekir Sanal, Gul Kulan
In recent years, several cases pointing at sacroiliitis due to isotretinoin treatment have been reported, but a causal association remains unproven. The aim of this study was to assess the characteristics of patients in whom bilateral sacroiliitis was detected while using isotretinoin treatment for acne and to review previous sacroiliitis cases treated with isotretinoin. In total, 11 patients who were diagnosed with sacroiliitis during isotretinoin treatment were identified, and patient characteristics were noted...
October 2017: Acta Dermatovenerologica Croatica: ADC
Mihaela Adriana Ghiţă, Constantin Căruntu, Adrian Eugen Rosca, Ana Căruntu, Liliana Moraru, Carolina Constantin, Monica Neagu, Daniel Boda
Capsaicin induces a localized inflammatory process known as neurogenic inflammation upon its topical administration on the skin, due to the release of various neuropeptides from the cutaneous sensory nerve endings. In this study, we investigated real-time skin blood flow changes that occur in neurogenic inflammation induced by topical capsaicin by means of in vivo reflectance confocal microscopy. 27 healthy subjects (15 women and 12 men, mean age ± Standard Deviation: 22.62±4.47) were administered topical capsaicin solution (Capsaicin group) or immersion oil (Control group) on the dorsal side of their non-dominant hand...
October 2017: Acta Dermatovenerologica Croatica: ADC
Zorica Sojević Timotijević, Predrag Majcan, Goran Trajković, Milijana Relić, Tatjana Novaković, Momčilo Mirković, Sladjana Djurić, Simon Nikolić, Bratislav Lazić, Slavenka Janković
Psoriasis severity varies by body region, with each affected region having a different impact on patient quality of life (QoL). The aim of this study was to assess the impact of changes in the Psoriasis Area and Severity Index (PASI) scores by body region on QoL in patients with psoriasis after treatment. A total of 100 patients with psoriasis were recruited to the study. All patients completed the generic EuroQol-5D instrument and two specific QoL measures, Dermatology Life Quality Index (DLQI) and Psoriasis Disability Index (PDI) at the beginning of the study, and 50 patients successfully completed the same questionnaires four weeks after the end of the treatment...
October 2017: Acta Dermatovenerologica Croatica: ADC
Amir Horev, Tamar Freud, Iris Manor, Arnon D Cohen, Alex Zvulunov
Atopic dermatitis (AD) is a common, chronic, inflammatory, pruritic skin disorder that affects up to 20% of the children in Western countries. Attention-Deficit/Hyperactivity disorder (ADHD) has been reported to be more frequent in children with AD. The purpose of this study was to explore the risk for ADHD in our population of patients with AD. A population-based case-control study, using the medical database of Clalit Health Services (CHS), the largest healthcare provider organization in Israel. The study included 840 patients with AD between the age of 0-18 years and 900 age and gender frequency-matched patients without AD...
October 2017: Acta Dermatovenerologica Croatica: ADC
Birgül Özkesici, Derya Mutlu, Levent Dönmez, Soner Uzun
Autoimmune bullous diseases (ABD) are a rarely seen group of diseases, of which pemphigus and bullous pemphigoid (BP) are the major groups. Diagnosis is generally based on the combination of clinical features, histopathologic and immunofluorescence (IF) findings, and/or enzyme-linked immunosorbent assay (ELISA). Aims of the work were to determine the value of the innovative BIOCHIP mosaic-based indirect IF technique in the diagnosis of pemphigus and BP in Turkish patients. A total of 63 patients (45 pemphigus and 18 BP) in the active phase of the disease alongside 35 healthy controls were included in the study...
October 2017: Acta Dermatovenerologica Croatica: ADC
Aikaterini Patsatsi, Foteini Lamprou, Miltiadis Kokolios, Despoina Stylianidou, Anastasia Trigoni, Dimitrios Kalampalikis, Dimitrios Sotiriadis
Bullous Diseases Unit at the 2nd Department of Dermatology and Venereology, Aristotle University of Thessaloniki was founded with the aim to provide the optimal diagnostic approach and treatment of patients with autoimmune bullous diseases (AΙBD). We processed all AIBD files of patients diagnosed from 2011 to 2014 in order to record all epidemiological data and therapeutic manipulations during monitoring. 57 patients were diagnosed with intraepidermal and 62 with subepidermal bullous diseases. There were 51 cases (89%) of pemphigus vulgaris (PV) and 6 (11%) of pemphigus foliaceus (PF), whereas 45 (73%) patients were diagnosed with bullous pemphigoid (BP), 9 (14%) with mucous membrane pemphigoid (MMP), 3 (5%) with pemphigoid gestationis (PG), 3 (5%) with linear IgA dermatosis (LAD), 1 (2%) with epidermolysis bullosa aquisita (EBA), and 1 patient with an undefined subepidermal AIBD...
October 2017: Acta Dermatovenerologica Croatica: ADC
Ece Altun A, Savas Yayli A, Bayram Toraman, Deniz Aksu Arica, Ersan Kalay, Leyla Baykal Selcuk, Sevgi Bahadir
Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering disease of the skin and mucous membranes. The relationship between PV and human leukocyte antigen (HLA) has been studied in several reports. Previous reports have demonstrated that HLA-E polymorphisms may have a role in the susceptibility to various autoimmune diseases. Our aim was to evaluate the role of HLA-E gene polymorphisms in the pathogenesis of PV in a Turkish population. A total of 49 patients with PV and 50 healthy subjects were enrolled into the study...
October 2017: Acta Dermatovenerologica Croatica: ADC
Savas Yayli, Mehmet Harman, Emel Bulbul Baskan, Ayse Akman Karakas, Yeser Genc, Bengu Gerceker Turk, Evren Odyakmaz Demirsoy, Suhan Gunasti, Serap Gunes Bilgili, Nilsel Ilter, Ayten Ferahbas, Ekin Savk, Fatma Sule Afsar, Sema Aytekin, Tamer Irfan Kaya, Sibel Berksoy Hayta, Zuleyha Ozgen, Mehmet Salih Gurel, Ercan Caliskan, Didem Didar Balci, Sule Gungor, Yelda Kapicioglu, Pinar Ozuguz, Sebnem Aktan, Asena Dogramaci, Ibrahim Kokcam, Nahide Onsun, Deniz Seckin, Murat Durdu, Recep Dursun, Munise Daye, Nursel Dilek, Ercan Karabacak, Asli Bilgic Temel, Cengizhan Erdem, Ece Altun, Dilek Gungor, Demet Kartal, Melih Akyol, Esra Koku Koku Aksu, Soner Uzun
Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey...
October 2017: Acta Dermatovenerologica Croatica: ADC
Piotr Nockowski, Zdzisław Woźniak, Adam Reich, Joanna Maj
Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention. Imaging assessment and ultrasound examination did not show any specific involvement of internal organs...
July 2017: Acta Dermatovenerologica Croatica: ADC
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
Tasleem Arif, Syed Suhail Amin, Mohammad Adil, Mohd Mohtashim
Dear Editor, Clouston syndrome, also called hidrotic ectodermal dysplasia (HED), is an autosomal dominant ectodermal dysplasia characterized by a clinical triad of onychodystrophy, generalized hypotrichosis, and palmoplantar keratoderma (1). Herein we report the case of a 24-year-old male with the distinctive clinical triad associated with multiple epidermoid cysts, which probably reflects the phenotype of Clouston syndrome. A 24-year-old male presented to our Department with diffuse thickening of the skin of his palms and soles since infancy...
July 2017: Acta Dermatovenerologica Croatica: ADC
Luca Roncati, Teresa Pusiol, Francesco Piscioli
The latest reviews on thin melanoma (TM) continue to consider it a melanoma within 1 mm in thickness, but no consensus exists as to which patients with TM are at risk for lymph node metastases (1). Numerous studies have evaluated the impact of various predictors (Breslow thickness, Clark level, ulceration, regression, vascular invasion, mitotic activity, location, sex) for nodal disease in melanoma, but the conclusions have not been homogenous (2,3). For this reason, we read the paper by Homolak et al. with great interest, where the authors examine the sentinel lymph node biopsies (SLNB) of 184 patients affected by melanoma of thickness less than 1...
July 2017: Acta Dermatovenerologica Croatica: ADC
Michał Adamczyk, Małgorzata Michalska-Jakubus, Dorota Krasowska
The association between Down syndrome and psoriasis is unclear. Immunological abnormalities that present in individuals with Down syndrome result in mild immune debilitation, thus the risk of infectious complications during immunosuppressive therapy might be higher in this group of patients. We present a case of 12-year-old girl with severe plaque psoriasis and Down syndrome, who was initially treated with cyclosporine with good response. However, the drug was withdrawn due to massive viral warts development and loss of efficacy...
July 2017: Acta Dermatovenerologica Croatica: ADC
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