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Journal of Medical Screening

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https://www.readbyqxmd.com/read/30049249/the-effect-of-mammography-screening-regimen-on-incidence-based-breast-cancer-mortality
#1
Martin J Yaffe, Nicole Mittmann, Oguzhan Alagoz, Amy Trentham-Dietz, Anna Na Tosteson, Natasha K Stout
Objectives Incidence-based mortality quantifies the distribution of cancer deaths and life-years lost, according to age at detection. We investigated the temporal distribution of the disease burden, and the effect of starting and stopping ages and interval between screening mammography examinations, on incidence-based mortality. Methods Incidence-based mortality was estimated using an established breast cancer simulation model, adapted and validated to simulate breast cancer incidence, screening performance, and delivery of therapies in Canada...
July 26, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/30049248/serum-marker-truncation-limits-in-first-trimester-antenatal-screening-for-trisomy-18
#2
Jonathan P Bestwick, Wayne J Huttly, Nicholas J Wald
Objective To assess whether the accuracy of risk estimation in antenatal screening for trisomy 18 using the Combined test can be improved by revising the truncation limits of two serum markers. Methods In an audit of data from 420 trisomy 18 and 573,754 unaffected singleton pregnancies screened at the Wolfson Institute of Preventive Medicine, London (March 2003 to June 2017), the accuracy of risk estimation was assessed by inspection of a validation plot (the median predicted late first trimester Combined test risk plotted against observed prevalence within categories of predicted risk estimates)...
July 26, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28929865/false-positive-screens-and-lung-cancer-risk-in-the-national-lung-screening-trial-implications-for-shared-decision-making
#3
Paul F Pinsky, Christina R Bellinger, David P Miller
Objectives Low-dose computed tomography lung cancer screening has been shown to reduce lung cancer mortality but has a high false-positive rate. The precision medicine approach to low-dose computed tomography screening assesses subjects' benefits versus harms based on their personal lung cancer risk, where harms include false-positive screens and resultant invasive procedures. We assess the relationship between lung cancer risk and the rate of false-positive LDCT screens. Methods The National Lung Screening Trial randomized high-risk subjects to three annual screens with low-dose computed tomography or chest radiographs...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28691862/simplifying-breast-imaging-reporting-and-data-system-classification-of-mammograms-with-pure-suspicious-calcifications
#4
Gisela Lg Menezes, Gonneke Ao Winter-Warnars, Eva L Koekenbier, Emma J Groen, Helena M Verkooijen, Ruud M Pijnappel
Objectives To investigate the risk of malignancy following stereotactic breast biopsy of calcifications classified as Breast Imaging Reporting and Data System (BI-RADS) 3, 4, and 5. Methods The study included women with pure calcifications (not associated with masses or architectural distortions) who underwent stereotactic breast biopsy at the Dutch Cancer Institute between January 2011 and October 2013. Suspicious calcifications (Breast Imaging Reporting and Data System 3, 4, or 5) detected on mammography were biopsied...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28686106/neonatal-screening-improves-sickle-cell-disease-clinical-outcome-in-belgium
#5
Phu-Quoc Lê, Alina Ferster, Laurence Dedeken, Christiane Vermylen, Anna Vanderfaeillie, Laurence Rozen, Catherine Heijmans, Sophie Huybrechts, Christine Devalck, Frédéric Cotton, Olivier Ketelslegers, Marie-Françoise Dresse, Jean-François Fils, Béatrice Gulbis
Objectives To compare the outcomes of sickle cell disease patients diagnosed through neonatal screening with those who were not. Methods In an observational multicenter study in Belgium, 167 screened and 93 unscreened sickle cell disease patients were analyzed for a total of 1116 and 958 patient-years of follow-up, respectively. Both groups were compared with propensity score analysis, with patients matched on three covariates (gender, genotype, and central Africa origin). Bonferroni correction was applied for all comparisons...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28675954/effect-of-population-breast-screening-on-breast-cancer-mortality-to-2005-in-england-and-wales-a-nested-case-control-study-within-a-cohort-of-one-million-women
#6
Louise E Johns, Anthony J Swerdlow, Susan M Moss
Objectives To evaluate the effectiveness of the NHS breast screening programme (NHSBSP) on breast cancer mortality in England and Wales and to compare findings with a cohort analysis of the same underlying population. Methods A nested case-control study within a cohort of 959,738 women in England and Wales aged 49-64 who were eligible for routine NHSBSP screening during 1991-2005. Cases who died from breast cancer in 1991-2005 were matched to controls without breast cancer at the case diagnosis date and alive when the case died...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28530515/cost-effectiveness-of-strategies-to-increase-cervical-screening-uptake-at-first-invitation-strategic
#7
Apostolos Tsiachristas, Matthew Gittins, Henry Kitchener, Alastair Gray
Objective To assess the cost-effectiveness of strategies to increase cervical cancer screening uptake at first invitation (STRATEGIC trial). Methods We performed an economic analysis alongside the STRATEGIC trial, comparing each of seven novel interventions for improving cervical screening uptake with control general practices in Greater Manchester and Grampian (United Kingdom). A template was developed to measure the intervention costs. Trial estimates of screening uptake were combined with data from the literature to estimate healthcare costs of each intervention...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28530514/public-understanding-of-the-purpose-of-cancer-screening-a-population-based-survey
#8
Amanda J Chorley, Yasemin Hirst, Charlotte Vrinten, Christian von Wagner, Jane Wardle, Jo Waller
Objectives In examining informed choice in cancer screening, we investigated public awareness that some screening programmes aim to prevent cancer, while others seek to detect cancer at an early stage. Methods A population-based survey of adults aged 50-70 in England (n = 1433), including data on demographic characteristics and screening experience. Participants were asked to select the main purpose of cervical, breast, and colorectal cancer screening (both faecal occult blood testing and flexible sigmoidoscopy)...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28530513/a-cluster-randomized-trial-of-strategies-to-increase-uptake-amongst-young-women-invited-for-their-first-cervical-screen-the-strategic-trial
#9
H Kitchener, M Gittins, M Cruickshank, C Moseley, S Fletcher, R Albrow, A Gray, L Brabin, D Torgerson, E J Crosbie, A Sargent, C Roberts
Objectives To measure the feasibility and effectiveness of interventions to increase cervical screening uptake amongst young women. Methods A two-phase cluster randomized trial conducted in general practices in the NHS Cervical Screening Programme. In Phase 1, women in practices randomized to intervention due for their first invitation to cervical screening received a pre-invitation leaflet and, separately, access to online booking. In Phase 2, non-attenders at six months were randomized to one of: vaginal self-sample kits sent unrequested or offered; timed appointments; nurse navigator; or the choice between nurse navigator or self-sample kits...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28467146/high-test-positivity-and-low-positive-predictive-value-for-colorectal-cancer-of-continued-faecal-occult-blood-test-screening-after-negative-colonoscopy
#10
Jeremy P Brown, Kate Wooldrage, Suzanne Wright, Claire Nickerson, Amanda J Cross, Wendy S Atkin
Objectives The English Bowel Cancer Screening Programme offers biennial guaiac faecal occult blood test (gFOBT) screening to 60-74-year-olds. Participants with positive results are referred for follow-up, but many do not have significant findings. If they remain age eligible, these individuals are reinvited for gFOBT screening. We evaluated the performance of repeat screening in this group. Methods We analysed data on programme participants reinvited to gFOBT screening after either previous negative gFOBT ( n = 327,542), or positive gFOBT followed by a diagnostic investigation negative for colorectal cancer (CRC) or adenomas requiring surveillance ( n = 42,280)...
June 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29183246/uptake-trends-in-the-scottish-bowel-screening-programme-and-the-influences-of-age-sex-and-deprivation
#11
Aaron J Quyn, Callum G Fraser, Greig Stanners, Francis A Carey, Claire Carden, Aasma Shaukat, Robert Jc Steele
Objective Age, sex, and deprivation are known factors influencing colorectal (bowel) cancer screening uptake. We investigated the influence of these factors on uptake over time. Methods Data from the Scottish Bowel Screening Programme (SBoSP) were collected between 2007 and 2014. End-points for analysis were uptake, faecal occult blood test positivity, and disease detection, adjusted for age, sex, deprivation, and year of screening. Results From 5,308,336 individual screening episodes documented, uptake gradually increased with increasing age up to 65-69 and was lower in men than women (52...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29183229/prevalence-of-sickle-cell-disease-among-grenadian-newborns
#12
Magdalene Antoine, Ketty Lee, Tyhiesia Donald, Yonni Belfon, Ali Drigo, Sharon Polson, Francis Martin, George Mitchell, Maryse Etienne-Julan, Marie-Dominique Hardy-Dessources
Objective To establish the birth prevalence of sickle cell disease in Grenada, with a view to assess the requirement for a population-based neonatal screening programme. Methods A two-year pilot neonatal screening programme, involving the Ministry of Health of Grenada, the Sickle Cell Association of Grenada, and the diagnostic laboratory of hemoglobinopathies of the University Hospital of Guadeloupe, was implemented in 2014-2015 under the auspices of the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29183226/analysis-of-follow-up-at-the-diagnostic-level-in-the-polish-universal-neonatal-hearing-screening-programme
#13
Grażyna Greczka, Monika Zych, Maciej Wróbel, Piotr Dąbrowski, Joanna Szyfter Harris, Witold Szyfter
Objectives Routine analysis showed that between 1 June and 30 November 2014, only 47.6% of expected follow-up visits at the diagnostic level were registered in the Polish Universal Neonatal Hearing Screening Programme central database. We attempted to detect and analyse the reasons for this low percentage. Methods A telephone survey questionnaire was developed for parents whose children had not registered for consultation at the diagnostic level, or had not received a final diagnosis according to the programme database...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28614992/preimplantation-genetic-screening
#14
Joyce C Harper
Preimplantation genetic diagnosis was first successfully performed in 1989 as an alternative to prenatal diagnosis for couples at risk of transmitting a genetic or chromosomal abnormality, such as cystic fibrosis, to their child. From embryos generated in vitro, biopsied cells are genetically tested. From the mid-1990s, this technology has been employed as an embryo selection tool for patients undergoing in vitro fertilisation, screening as many chromosomes as possible, in the hope that selecting chromosomally normal embryos will lead to higher implantation and decreased miscarriage rates...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28614991/invitation-coverage-and-participation-in-italian-cervical-breast-and-colorectal-cancer-screening-programmes
#15
Paolo Giorgi Rossi, Giuliano Carrozzi, Antonio Federici, Pamela Mancuso, Letizia Sampaolo, Marco Zappa
Objectives In Italy, regional governments organize cervical, breast and colorectal cancer screening programmes, but there are difficulties in regularly inviting all the target populations and participation remains low. We analysed the determinants associated with invitation coverage of and participation in these programmes. Methods We used data on screening programmes from annual Ministry of Health surveys, 1999-2012 for cervical, 1999-2011 for breast and 2005-2011 for colorectal cancer. For recent years, we linked these data to the results of the national routine survey on preventive behaviours to evaluate the effect of spontaneous screening at Province level...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28614990/screening-organization-and-recall-rate-in-a-regional-breast-screening-programme
#16
Tina Beruchashwili, Rema Gvamichava, Stephen W Duffy
Objective To use results on recall rates from a regional non-population-based breast screening programme to inform practice in a planned national population-based programme. Methods We analysed data on rates of recall for further assessment in 27,327 mammographic screening episodes in 2015-2016 in the breast screening programme in the city of Tbilisi, Georgia. Screening was done by two-view digital mammography with double reading in women aged 40-70, and further assessment took place at the same clinic and during the same visit as the initial screening mammogram...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28454512/optimization-of-the-french-cystic-fibrosis-newborn-screening-programme-by-a-centralized-tracking-process
#17
Anne Munck, Dominique Delmas, Marie-Pierre Audrézet, Lydie Lemonnier, David Cheillan, Michel Roussey
Objectives To evaluate the French cystic fibrosis newborn screening algorithm, based on data tracked by a centralized monitoring process, from 2002 to 2014. The programme aimed to attain European Standards in terms of positive predictive value, sensitivity, the ratio of screen positive patients diagnosed with cystic fibrosis to infants who screen positive but with inconclusive diagnosis (CFSPID), and time to diagnosis. Methods Retrospective analysis of programme performance, compliance with the algorithm, and changes in screening strategy...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28423979/pregnancy-associated-plasma-protein-a-truncation-limits-in-antenatal-screening-for-trisomy-18
#18
J P Bestwick, W J Huttly, N J Wald
Upper and lower truncation limits are commonly applied to quantitative markers used in medical screening tests. We here examine data on 375 trisomy 18 and 522,081 unaffected singleton pregnancies, to determine if the lower truncation limit should be set below the previously specified 0.2 multiples of the median. A lower truncation limit of 0.15 would reduce the underestimation of the risk of having a trisomy 18 pregnancy in about 50% of affected pregnancies and would lead to an estimated 10 percentage point increase in the detection rate, with only a very small increase in the false-positive rate...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28372514/embedded-survey-study-harms-colorectal-cancer-screening-attendance-experiences-from-finland-2010-to-2015
#19
Sanni Helander, Tytti Sarkeala, Nea Malila
Objective We previously found that administering a pre-screening lifestyle questionnaire lowered the subsequent attendance proportion in the first-ever colorectal cancer screening. We sought to determine whether the effect continued in subsequent screening rounds. Methods The eligible survey cohort ( n = 10,375) received a follow-up questionnaire in 2012, and in 2013, they were invited for colorectal cancer screening for the second time. For the third screening round, in 2015, no questionnaires were sent in the previous year...
March 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/28195508/incidence-of-interval-cancers-in-faecal-immunochemical-test-colorectal-screening-programmes-in-italy
#20
Paolo Giorgi Rossi, Elisa Carretta, Lucia Mangone, Susanna Baracco, Diego Serraino, Manuel Zorzi
Objective In Italy, colorectal screening programmes using the faecal immunochemical test from ages 50 to 69 every two years have been in place since 2005. We aimed to measure the incidence of interval cancers in the two years after a negative faecal immunochemical test, and compare this with the pre-screening incidence of colorectal cancer. Methods Using data on colorectal cancers diagnosed in Italy from 2000 to 2008 collected by cancer registries in areas with active screening programmes, we identified cases that occurred within 24 months of negative screening tests...
March 2018: Journal of Medical Screening
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