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Journal of Medical Screening

Sherry Yueh-Hsia Chiu, Nea Malila, Amy Ming-Fang Yen, Sam Li-Sheng Chen, Jean Ching-Yuan Fann, Matti Hakama
Objective Because colorectal cancer (CRC) has a long natural history, estimating the effectiveness of CRC screening programmes requires long-term follow-up. As an alternative, we here demonstrate the use of a temporal multi-state natural history model to predict the effectiveness of CRC screening. Methods In the Finnish population-based biennial CRC screening programme using faecal occult blood tests (FOBT), which was conducted in a randomised health services study, we estimated the pre-clinical incidence, the mean sojourn time (MST), and the sensitivity of FOBT using a Markov model to analyse data from 2004 to 2007...
January 1, 2017: Journal of Medical Screening
Johannes Dm Otten, Guido van Schoor, Petronella Gm Peer, Gerard J den Heeten, Roland Holland, Mireille Jm Broeders, André Lm Verbeek
Objective As breast cancer growth rate is associated with menopause, most screening programmes target mainly women aged 50-74. We studied the association between age at diagnosis and growth rate in this screening-specific age range. Methods We used data from breast cancer patients diagnosed in the screening programme in Nijmegen, the Netherlands. The data were restricted to the screening rounds when analogue mammography was used in both the screening and clinical setting. Growth rate expressed as tumour volume doubling time was based on increasing tumour size in longitudinal series of mammograms...
January 1, 2017: Journal of Medical Screening
Damien Bennett, Diane Stewart, Deirdre Kearns, Adrian Mairs, Peter Ellis
Objectives To compare abdominal aortic aneurysm screening outcomes of men with non-visualized aorta at original scan with subsequent scans and to determine predictors of non-visualized aorta. Methods In the Northern Ireland Abdominal Aortic Aneurysm screening programme, outcomes (discharge, annual surveillance, three-monthly surveillance, or vascular referral) and patient and programme characteristics (age, deprivation quintile, family history, technician experience, and screening location) for men with non-visualized aorta were investigated at original scan, and first and second rescans...
January 1, 2017: Journal of Medical Screening
Maiju Pankakoski, Sirpa Heinävaara, Tytti Sarkeala, Ahti Anttila
Objective Regular screening and follow-up is an important key to cervical cancer prevention; however, screening inevitably detects mild or borderline abnormalities that would never progress to a more severe stage. We analysed the cumulative probability and recurrence of cervical abnormalities in the Finnish organized screening programme during a 22-year follow-up. Methods Screening histories were collected for 364,487 women born between 1950 and 1965. Data consisted of 1 207,017 routine screens and 88,143 follow-up screens between 1991 and 2012...
January 1, 2017: Journal of Medical Screening
Erin L Symonds, Stephen R Cole, Dawn Bastin, Robert Jl Fraser, Graeme P Young
Objectives Faecal immunochemical test accuracy may be adversely affected when samples are exposed to high temperatures. This study evaluated the effect of two sample collection buffer formulations (OC-Sensor, Eiken) and storage temperatures on faecal haemoglobin readings. Methods Faecal immunochemical test samples returned in a screening programme and with ≥10 µg Hb/g faeces in either the original or new formulation haemoglobin stabilizing buffer were stored in the freezer, refrigerator, or at room temperature (22℃-24℃), and reanalysed after 1-14 days...
January 1, 2017: Journal of Medical Screening
Enkeleint-Aggelos Mechili, Dimitra Sifaki-Pistolla
No abstract text is available yet for this article.
January 1, 2017: Journal of Medical Screening
Maryam Doroudi, Barnett S Kramer, Paul F Pinsky
OBJECTIVE: To provide evidence about the performance characteristics and consequences of bimanual ovarian palpation. SETTING AND METHODS: The Prostate, Lung, Colorectal and Ovarian cancer screening trial randomized 154,900 individuals to either an intervention or control arm. Enrolled eligible participants were aged 55-74, had no history of trial cancers, and no current treatment for cancer. Intervention arm women received CA-125 tests and transvaginal ultrasound...
November 30, 2016: Journal of Medical Screening
Florence Molinié, Solenne Delacour-Billon, Brigitte Tretarre, Patricia Delafosse, Brigitte Seradour, Marc Colonna
OBJECTIVE: A decrease in advanced breast cancer incidence is considered an early indicator of breast cancer mortality reduction in a screening programme. We describe trends in breast cancer incidence according to tumour size and age in three French administrative areas, where an organized screening programme was implemented during the 1990s. METHODS: Our study included all 28,092 invasive breast cancers diagnosed from 2000 to 2010 in women living in three areas (Hérault, Isère, Loire-Atlantique)...
November 3, 2016: Journal of Medical Screening
Daniel Hughes, Sunil Nair, John N Harvey
OBJECTIVES: To determine the necessary screening interval for retinopathy in diabetic patients with no retinopathy based on time to laser therapy and to assess long-term visual outcome following screening. METHODS: In a population-based community screening programme in North Wales, 2917 patients were followed until death or for approximately 12 years. At screening, 2493 had no retinopathy; 424 had mostly minor degrees of non-proliferative retinopathy. Data on timing of first laser therapy and visual outcome following screening were obtained from local hospitals and ophthalmology units...
November 3, 2016: Journal of Medical Screening
Andrew Coldman, Dirk van Niekerk, Laurie Smith, Gina Ogilvie
OBJECTIVES: To estimate the impact of increased participation in screening, and of the proposed change from Pap to human papillomavirus screening on the incidence of cervical cancer in British Columbia. METHODS: For invasive cervical cancer cases diagnosed in British Columbia between 2002 and 2011, data were extracted on age and cancer morphology from the British Columbia Cancer Registry, and Pap screening history was obtained from the British Columbia Cervical Cancer Screening Program database...
November 3, 2016: Journal of Medical Screening
Jessica Chubak, Rebecca Hubbard
BACKGROUND: The importance of cancer screening is well-recognized, yet there is great variation in how adherence is defined and measured. This manuscript identifies measures of screening adherence and discusses how to estimate them. DISCUSSION: We begin by describing why screening adherence is of interest: to anticipate long-term outcomes, to understand differences in outcomes across settings, and to identify areas for improvement. We outline questions of interest related to adherence, including questions about uptake, currency or being up-to-date, and longitudinal adherence, and then identify which measures are most appropriate for each question...
December 2016: Journal of Medical Screening
Dimitrios Michalopoulos, Stephen W Duffy
BACKGROUND: Estimating overdiagnosis in cancer screening is complicated. Using observational data, estimation of the expected incidence in the screening period and taking account of lead time are two major problems. METHODS: Using data from the Cancer Registry of Norway and the Norwegian Breast Cancer Screening Programme, we estimated incidence trends, using age-specific trends by year in the pre-screening period (1985-95). We also estimated sojourn time and sensitivity using interval cancers only...
December 2016: Journal of Medical Screening
Stephen W Duffy, Jonathan P Myles, Roberta Maroni, Abeera Mohammad
OBJECTIVE: Screening participation is spread differently across populations, according to factors such as ethnicity or socioeconomic status. We here review the current evidence on effects of interventions to improve cancer screening participation, focussing in particular on effects in underserved populations. METHODS: We selected studies to review based on their characteristics: focussing on population screening programmes, showing a quantitative estimate of the effect of the intervention, and published since 1990...
October 17, 2016: Journal of Medical Screening
Paula A van Luijt, Eveline Am Heijnsdijk, Nicolien T van Ravesteyn, Solveig Hofvind, Harry J de Koning
OBJECTIVE: Fluctuations in the incidence of breast cancer in Norway in the last three decades are partly explained by the use of hormone replacement therapy and mammography screening, but overdiagnosis has also been suggested as a cause. We assessed the trends in breast cancer incidence and overdiagnosis in Norway. METHODS: We calibrated our microsimulation model to Norwegian Cancer Registration data. The model takes into account the use of mammography (both within and outside the Norwegian Breast Cancer Screening Programme) and of hormone replacement therapy...
October 17, 2016: Journal of Medical Screening
Basilio Passamonti, Daniela Gustinucci, Paolo Giorgi Rossi, Elena Cesarini, Simonetta Bulletti, Angela Carlani, Nadia Martinelli, Massimo Broccolini, Valentina D'Angelo, Maria Rosaria D'Amico, Eugenio Di Dato, Paola Galeazzi, Morena Malaspina, Nicoletta Spita, Beatrice Tintori, Maria Donata Giaimo
OBJECTIVE: To present the results of the first and second round human papilloma virus (HPV)-based screening programme in the Umbria region after three years. METHODS: From August 2010 to November 2011, the entire female population aged 35-64 in a local health district was invited for HPV testing (HPV-DNA cobas4800 on a liquid-based cytology sample). HPV-negative women were re-invited after three years. For HPV-positive women, a slide was prepared and interpreted...
September 10, 2016: Journal of Medical Screening
Deborah Saraste, Anna Martling, Per J Nilsson, Johannes Blom, Sven Törnberg, Rolf Hultcrantz, Martin Janson
OBJECTIVES: To report complications after colonoscopy and surgery in patients with neoplasia detected through a population based colorectal cancer (CRC) screening programme in the capital region of Sweden. METHODS: Patients who after a positive FOBT screening result underwent colonoscopy from 1 January 2008 to 30 June 2012 were included. Mortality and complications within 30 days after colonoscopy or subsequent surgery were identified through national registers, and complications were assessed through review of medical charts...
September 2016: Journal of Medical Screening
Sue Hudson, Debbie Brazil, William Teh, Stephen W Duffy, Jonathan P Myles
OBJECTIVES: To estimate the effect on breast screening uptake of delayed, targeted, second timed appointments in women who did not take up an initial breast cancer screening appointment offer. METHODS: Non-attending women received a four-month delayed second timed appointment following non-response to the initial invitation and the normal open invitation sent to non-attenders. A comparison group was sent a four-month delayed additional open invitation. RESULTS: Response to the second timed appointments (percentage of re-invited women eventually attending in this episode) was 20%, corresponding to an estimated increase on total uptake of 6%...
September 2016: Journal of Medical Screening
Sharon Jb Hanley, Hiromasa Fujita, Susumu Yokoyama, Shiori Kunisawa, Akiko Tamakoshi, Peixin Dong, Noriko Kobayashi, Hidemichi Watari, Masataka Kudo, Noriaki Sakuragi
OBJECTIVES: Cervical cancer incidence and mortality is increasing in Japanese women under age 50. Screening uptake is low and proactive recommendations for human papillomavirus vaccination have been suspended. Other cervical cancer prevention initiatives are urgently needed. We assessed whether human papillomavirus self-sampling might be an acceptable alternative to physician-led screening, particularly in women with limited experience of tampon use. We also sought to identify any practical, logistical, or safety issues in women already attending for screening, before carrying out further large-scale studies in non-responders...
September 2016: Journal of Medical Screening
S Hofvind, R L Bennett, J Brisson, W Lee, E Pelletier, A Flugelman, B Geller
OBJECTIVE: Providing feedback to mammography radiologists and facilities may improve interpretive performance. We conducted a web-based survey to investigate how and why such feedback is undertaken and used in mammographic screening programmes. METHODS: The survey was sent to representatives in 30 International Cancer Screening Network member countries where mammographic screening is offered. RESULTS: Seventeen programmes in 14 countries responded to the survey...
September 2016: Journal of Medical Screening
Nicholas J Wald, Peter Oppenheimer
No abstract text is available yet for this article.
September 2016: Journal of Medical Screening
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