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Menopause: the Journal of the North American Menopause Society

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https://www.readbyqxmd.com/read/28098599/is-there-a-serm-in-your-menopause-toolkit
#1
James H Liu
Over the past 3 decades, compounds called selective estrogen receptor modulators (SERMs) have been developed that block the estrogen receptor in some tissues (estrogen receptor antagonists) or stimulate the estrogen receptor in other tissues (estrogen receptor agonists). This Practice Pearl focuses on SERMs that clinicians can use for menopausal patients.
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28098598/science-of-intracrinology-in-postmenopausal-women
#2
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F Archer, Wulf H Utian
OBJECTIVE: To illustrate the marked differences between classical endocrinology that distributes hormones to all tissues of the body through the bloodstream and the science of intracrinology, whereby each cell of each peripheral tissue makes a small and appropriate amount of estrogens and androgens from the inactive precursor dehydroepiandrosterone (DHEA), DHEA being mainly of adrenal origin. Because only the inactivated sex steroids are released in the blood, influence in the other tissues is avoided...
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28072610/sexual-activity-and-function-assessment-in-middle-aged-chinese-women-using-the-female-sexual-function-index
#3
Caiyun Zhang, Liping Cui, Lizhi Zhang, Chang Shi, Hong Zang
OBJECTIVE: To assess sexual activity, sexual function, and their correlation with vaginal maturation status among middle-aged Chinese women. METHODS: A cross-sectional study with comparisons across age groups was carried out. In all, 120 women aged 45 to 60 years were recruited into three groups: 45 to 50 (youngest group), 51 to 55 (intermediate group), and 56 to 60 years old (eldest group). Sexual function was assessed through the Female Sexual Function Index (FSFI); vaginal maturation status was determined through the Vaginal Maturation Index (VMI) and pH value...
January 9, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28072609/the-impact-of-estrogen-alone-hormone-therapy-on-breast-cancer-risk-and-health-outcomes-reassurance-for-the-treatment-of-climacteric-symptoms-in-black-women
#4
Aaron K Styer
No abstract text is available yet for this article.
January 9, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28072608/is-it-wise-to-link-vasomotor-symptoms-with-cardiovascular-disease
#5
Cynthia A Stuenkel
No abstract text is available yet for this article.
January 9, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28072607/letters-to-the-editor
#6
Mavin Macauley, Richard Quinton
No abstract text is available yet for this article.
January 9, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28002202/bh4-improves-postprandial-endothelial-function-after-a-high-fat-meal-in-men-and-postmenopausal-women
#7
Yashesh Shah, Leon Bass, Gareth W Davison, Nichole Seigler, Jennifer S Pollock, Jeff Thomas, Ryan A Harris
OBJECTIVE: The timing and duration of menopause is important when evaluating the risk for cardiovascular disease in postmenopausal women, likely related in part to nitric oxide (NO) bioavailability. The flow-mediated dilation (FMD) test is a noninvasive assessment of NO bioavailability in humans, and tetrahydrobiopterin (BH4) is essential for NO synthesis. A high-fat meal (HFM) has been used to increase lipemia and reduce NO bioavailability. Thus, this study sought to determine if menopausal transition has any impact on the postprandial endothelial function response to a HFM, and evaluate the effect of BH4 on postprandial endothelial function in postmenopausal women and men...
December 19, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28002201/tx-004hr-vaginal-estradiol-has-negligible-to-very-low-systemic-absorption-of-estradiol
#8
David F Archer, Ginger D Constantine, James A Simon, Harvey Kushner, Philip Mayer, Brian Bernick, Shelli Graham, Sebastian Mirkin
OBJECTIVE: To evaluate the pharmacokinetics of TX-004HR vaginal estradiol softgel capsules when used for treating moderate-to-severe dyspareunia in postmenopausal women with vulvar and vaginal atrophy. METHODS: A substudy of the REJOICE trial (multicenter, double-blind, placebo-controlled, phase 3) evaluated the pharmacokinetics of 4, 10, and 25-μg TX-004HR doses once/d for 2 weeks, followed by twice/wk for 10 weeks. Serum samples obtained at 2, 4, 6, 10, and 24 hours postdose on days 1 and 14, and once on day 84, were analyzed for area under the serum concentration-time curve, tmax, Cmin, Cavg, and Cmax for estradiol, estrone, and estrone conjugates...
December 19, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28002200/association-between-expression-of-inflammatory-markers-in-normal-breast-tissue-and-mammographic-density-among-premenopausal-and-postmenopausal-women
#9
Mirette Hanna, Isabelle Dumas, Michèle Orain, Simon Jacob, Bernard Têtu, François Sanschagrin, Alexandre Bureau, Brigitte Poirier, Caroline Diorio
OBJECTIVE: Inflammatory markers may be associated with breast cancer risk. We assessed the association between expression levels of proinflammatory (interleukin 6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase 2, leptin, serum amyloid A1, interleukin 8, and signal transducer and activator of transcription 3) and anti-inflammatory markers (transforming growth factor-β, interleukin 10, and lactoferrin) in normal breast tissue with mammographic density, a strong breast cancer risk indicator, among 163 breast cancer patients...
December 19, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27977502/work-stress-and-menopausal-symptoms
#10
Lila E Nachtigall
No abstract text is available yet for this article.
December 12, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27977501/letters-to-the-editor
#11
Tom G Bailey, Tim Cable, Nabil Aziz, Rebecca Dobson, Victoria S Sprung, David A Low, Helen Jones
No abstract text is available yet for this article.
December 12, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922943/letters-to-the-editor
#12
Ann Steiner
No abstract text is available yet for this article.
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922942/letters-to-the-editor
#13
Allison J Huang, Peter Ganz, Deborah Grady, Steven R Cummings
No abstract text is available yet for this article.
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922941/exercise-training-ameliorates-glucosamine-induced-insulin-resistance-in-ovariectomized-rats
#14
Chung-Hwan Chen, Tsang-Hai Huang, Tsung-Lin Cheng, Chi-Fen Chang, Chau-Zen Wang, Meng-Hsing Wu, Lin Kang
OBJECTIVE: Glucosamine (GlcN), which has been reported to induce insulin resistance (IR), is a popular nutritional supplement used to treat osteoarthritis in menopausal women. We previously demonstrated that GlcN treatment caused IR in ovariectomized rats by reducing the expression of glucose transport protein subtype 4 (GLUT-4) in skeletal muscle. In the present study, we hypothesized that endurance exercise training can reverse GlcN-induced IR. METHODS: Fifty female rats were randomly divided into five groups with 10 rats in each group: (1) sham-operated group; (2) sham-operated group with GlcN treatment for 14 days; (3) ovariectomy (OVX) group; (4) OVX with GlcN treatment; and (5) OVX with GlcN treatment followed by exercise training (running program) for 8 weeks...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922940/impact-of-menopausal-status-on-negative-mood-and-depressive-symptoms-in-a-longitudinal-sample-spanning-20-years
#15
Katherine E Campbell, Lorraine Dennerstein, Sue Finch, Cassandra E Szoeke
OBJECTIVE: Studies examining depressive symptoms and negative mood across the postmenopause are lacking, particularly those that examine prevalence in early and late postmenopause. This study examines negative mood and depressive occurrence in the menopausal stages to provide a better understanding of prevalence of mood disturbance during this period. METHODS: This study was a longitudinal assessment of variables drawn from an epidemiological prospective study of women's healthy aging...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922939/telomere-length-is-longer-in-women-with-late-maternal-age
#16
Erin Fagan, Fangui Sun, Harold Bae, Irma Elo, Stacy L Andersen, Joseph Lee, Kaare Christensen, Bharat Thyagarajan, Paola Sebastiani, Thomas Perls, Lawrence S Honig, Nicole Schupf
OBJECTIVE: Maternal age at birth of last child has been associated with maternal longevity. The aim of this study was to determine whether older women with a history of late maternal age at last childbirth had a longer leukocyte telomere length than those with maternal age at last childbirth of 29 years or less. METHODS: A nested case control study was conducted using data from the Long Life Family Study. Three hundred eighty-seven women who gave birth to at least one child and lived to the top fifth percentile of their birth cohort, or died before the top fifth percentile of their birth cohort died, but were at least 70 years old, were studied...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922938/skeletal-muscle-mass-is-associated-with-higher-dietary-protein-intake-and-lower-body-fat-in-postmenopausal-women-a-cross-sectional-study
#17
Thaís R Silva, Poli M Spritzer
OBJECTIVE: We investigated the association between skeletal muscle mass and dietary protein intake, habitual physical activity, body composition, and metabolic variables. METHODS: One hundred three healthy postmenopausal women from southern Brazil (age 55.2 ± 4.9 y, body mass index 27.2 ± 4.6 kg/m) were enrolled. Bone mineral density, %body fat, %trunk fat mass, and appendicular lean mass were assessed by dual-energy x-ray absorptiometry, resting metabolic rate by indirect calorimetry, and habitual physical activity by pedometer...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922937/repurposing-ospemifene-for-potentiating-an-antigen-specific-immune-response
#18
Chiao-Jung Kao, Gregory T Wurz, Yi-Chen Lin, Daniel P Vang, Brian Phong, Michael W DeGregorio
OBJECTIVE: Ospemifene, an estrogen receptor agonist/antagonist approved for the treatment of dyspareunia and vaginal dryness in postmenopausal women, has potential new indications as an immune modulator. The overall objective of the present series of preclinical studies was to evaluate the immunomodulatory activity of ospemifene in combination with a peptide cancer vaccine. METHODS: Immune regulating effects, mechanism of action and structure activity relationships of ospemifene and related compounds were evaluated by examining expression of T-cell activating cytokines in vitro, and antigen-specific immune response and cytotoxic T-lymphocyte activity in vivo...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922936/the-rejoice-trial-a-phase-3-randomized-controlled-trial-evaluating-the-safety-and-efficacy-of-a-novel-vaginal-estradiol-soft-gel-capsule-for-symptomatic-vulvar-and-vaginal-atrophy
#19
Ginger D Constantine, James A Simon, James H Pickar, David F Archer, Harvey Kushner, Brian Bernick, Gina Gasper, Shelli Graham, Sebastian Mirkin
OBJECTIVE: To evaluate the safety and efficacy of TX-004HR vaginal estradiol soft-gel capsules for moderate-to-severe dyspareunia associated with postmenopausal vulvar and vaginal atrophy. METHODS: In this randomized, double-blind, placebo-controlled, phase 3 study, postmenopausal women with a self-identified most bothersome symptom of dyspareunia received 4, 10, or 25 μg TX-004HR or placebo for 12 weeks. Four co-primary efficacy endpoints were change from baseline to week 12 in percentages of superficial and parabasal cells, vaginal pH, and severity of dyspareunia...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922935/enhancing-memory-self-efficacy-during-menopause-through-a-group-memory-strategies-program
#20
Anne E Unkenstein, Bei Bei, Christina A Bryant
OBJECTIVE: Anxiety about memory during menopause can affect quality of life. We aimed to improve memory self-efficacy during menopause using a group memory strategies program. METHODS: The program was run five times for a total of 32 peri- and postmenopausal women, age between 47 and 60 years, recruited from hospital menopause and gynecology clinics. The 4-week intervention consisted of weekly 2-hour sessions, and covered how memory works, memory changes related to ageing, health and lifestyle factors, and specific memory strategies...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
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