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Menopause: the Journal of the North American Menopause Society

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https://www.readbyqxmd.com/read/29462096/patterns-of-menopausal-hormone-therapy-use-and-hyperkyphosis-in-older-women
#1
Gina N Woods, Mei-Hua Huang, Peggy M Cawthon, Corinne McDaniels-Davidson, Howard A Fink, Deborah M Kado
OBJECTIVE: Hyperkyphosis, an exaggerated anterior curvature of the thoracic spine, is associated with poor physical function, falls, fractures, and earlier mortality. Low bone mineral density, bone loss, and vertebral fractures are strong risk factors for hyperkyphosis. Menopausal hormone therapy (HT) reverses bone loss, prevents vertebral fractures, and, therefore, we hypothesize, may reduce the risk for developing hyperkyphosis. METHODS: We evaluated the cross-sectional association between Cobb angle of kyphosis from lateral spine radiographs and pattern of self-reported HT use during the prior 15-year period in 1,063 women from the Study of Osteoporotic Fractures...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29462095/hormonal-metabolic-and-endometrial-safety-of-testosterone-vaginal-cream-versus-estrogens-for-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-a-randomized-placebo-controlled-study
#2
Tatiane Fernandes, Adriana O Pedro, Luiz F Baccaro, Lucia H Costa-Paiva
OBJECTIVE: The aim of the study was to evaluate the laboratory and endometrial safety of topical testosterone versus topical estrogen for the treatment of vaginal atrophy in postmenopausal women. METHODS: This was a randomized, placebo-controlled trial of 60 postmenopausal women aged 40 to 70 years at the Menopause Clinic of CAISM UNICAMP. Women were randomized into three vaginal treatment groups: estrogen, testosterone, or placebo. The treatment was applied 3 times a week for 12 weeks...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29462094/effects-of-abaloparatide-on-bone-mineral-density-and-risk-of-fracture-in-postmenopausal-women-aged-80-years-or-older-with-osteoporosis
#3
Michael R McClung, Nicholas C Harvey, Lorraine A Fitzpatrick, Paul D Miller, Gary Hattersley, Yamei Wang, Felicia Cosman
OBJECTIVE: Advanced age is an important risk factor for fracture. The Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) trial showed that subcutaneous abaloparatide increased bone mineral density (BMD) and reduced the risk of vertebral and nonvertebral fractures in postmenopausal women with osteoporosis. This study describes the effects of abaloparatide in the subgroup of women aged 80 or more years in ACTIVE. METHODS: Post hoc analyses of BMD and fracture incidence in this subgroup of women who received abaloparatide or placebo in the 18-month, phase 3, double-blind, randomized controlled ACTIVE trial...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29462093/contraception-for-midlife-women-a-review
#4
Taniqua A Miller, Rebecca H Allen, Andrew M Kaunitz, Carrie A Cwiak
Family planning represents a key component of reproductive health care. Accordingly, the provision of contraception must span the reproductive age spectrum, including perimenopause. The risk of pregnancy is decreased, but not trivial, among women over 40 years of age. Evidence-based guidelines for contraceptive use can assist clinicians in counseling their patients in this population. Intrauterine contraception is one of the most effective methods and is safe to use in midlife women with few exceptions. Progestin-only contraception is another safe option for most midlife women because it is not associated with an increased risk of cardiovascular complications...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29438272/cardiovascular-risk-after-withdrawal-of-hormone-therapy
#5
Howard N Hodis, Wendy J Mack
No abstract text is available yet for this article.
February 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29438271/efficacy-of-misoprostol-before-diagnostic-hysteroscopy-in-postmenopausal-women-a-randomized-clinical-trial
#6
Fabiana Y Nakano, Daniela A Yela, Joao P L Pinto, Talita Riegas, Cristina L Benetti-Pinto, Adriana Orcesi Pedro, Lucia Helena Costa Paiva
OBJECTIVE: To evaluate pain and determine the efficacy of misoprostol, compared with placebo, for postmenopausal women before diagnostic hysteroscopy. METHODS: This randomized, double-blind, placebo-controlled clinical trial included 158 postmenopausal women who received either 200 μg of misoprostol or placebo through the vaginal route before diagnostic hysteroscopy (79 women/group). The primary outcome was pain assessment (presence and intensity) during the four steps of hysteroscopy: cervical grasping with a Pozzi tenaculum forceps immediately before hysteroscopy, during hysteroscopy, during performance of the endometrial biopsy, and postprocedure...
February 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29438270/women-s-health-initiative-and-rate-of-hormone-use-a-study-that-impacted-a-whole-generation
#7
Amos Pines
No abstract text is available yet for this article.
February 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29438269/the-effects-of-stair-climbing-on-arterial-stiffness-blood-pressure-and-leg-strength-in-postmenopausal-women-with-stage-2-hypertension
#8
Alexei Wong, Arturo Figueroa, Won-Mok Son, Oksana Chernykh, Song-Young Park
OBJECTIVE: Menopause is accompanied by a progressive arterial stiffening associated with increases in blood pressure (BP) and decline in muscular function. It is crucial to prevent or reduce the negative effects of menopause on vascular and muscular function by implementing appropriate lifestyle interventions, such as exercise training. We examined the effects of a stair climbing (SC) regimen on arterial stiffness (pulse wave velocity [PWV]), BP, and leg strength in postmenopausal women with stage 2 hypertension...
February 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29406427/comparisons-of-low-intensity-versus-moderate-intensity-combined-aerobic-and-resistance-training-on-body-composition-muscle-strength-and-functional-performance-in-older-women
#9
Yoko Shiotsu, Masahiko Yanagita
OBJECTIVE: This study aimed to examine the effects of exercise order of combined aerobic and low- or moderate-intensity resistance training into the same session on body composition, functional performance, and muscle strength in healthy older women. Furthermore, this study compared the effects of different (low- vs moderate-) intensity combined training. METHODS: A total of 60 healthy older women (age 61-81 y) were randomly assigned to five groups that performed aerobic exercise before low-intensity resistance training (AR-L, n = 12) or after resistance training (RA-L, n = 12), performed aerobic exercise before moderate-intensity resistance training (AR-M, n = 12) or after resistance training (RA-M, n = 12), or nonintervention control conditions (CON, n = 12)...
February 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29406426/history-of-vasomotor-symptoms-extent-of-coronary-artery-disease-and-clinical-outcomes-after-acute-coronary-syndrome-in-postmenopausal-women
#10
Luca A Ferri, Nuccia Morici, Giorgio Bassanelli, Nicoletta Franco, Leonardo Misuraca, Laura Lenatti, Emilia Lo Jacono, Chiara Leuzzi, Elena Corrada, Tiziana C Aranzulla, Delia Colombo, Angelo Cagnacci, Francesco Prati, Stefano Savonitto
OBJECTIVE: Vasomotor symptoms (VMS) during menopausal transition have been linked to a higher burden of cardiovascular risk factors, subclinical vascular disease, and subsequent vascular events. We aim to investigate the association of VMS with the extent of coronary disease and their prognostic role after an acute coronary syndrome. METHODS: The Ladies Acute Coronary Syndrome study enrolled consecutive women with an acute coronary syndrome undergoing coronary angiography...
February 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29406425/vulvar-and-vaginal-fractional-co2-laser-treatments-for-genitourinary-syndrome-of-menopause
#11
Lauren F Streicher
Many healthcare providers are offering women treatment with the fractionated CO2 laser for a myriad of gynecologic issues, including genitourinary syndrome of menopause (GSM). Because existing data are limited, providing guidance is challenging. This Practice Pearl addresses what we know and don't know about the use of the fractionated CO2 laser for the treatment of GSM.
February 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381667/constipation-and-diarrhea-during-the-menopause-transition-and-early-postmenopause-observations-from-the-seattle-midlife-women-s-health-study
#12
Nini G L Callan, Ellen S Mitchell, Margaret M Heitkemper, Nancy F Woods
OBJECTIVE: To assess the relationship of constipation and diarrhea severity during the menopause transition (MT) with age, MT stage, reproductive biomarkers, stress-related biomarkers, and stress-related perceptions. METHODS: From 1990 to 1992, women aged 35 to 55 years were recruited from the greater Seattle area; 291 of them consented to ongoing (1990-2013) annual data collection by daily menstrual calendar, health diary, and annual health questionnaire. A subset (n = 131) provided a first morning voided urine specimen (1997-2013)...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381666/effects-of-oral-conjugated-equine-estrogens-with-or-without-medroxyprogesterone-acetate-on-incident-hypertension-in-the-women-s-health-initiative-hormone-therapy-trials
#13
Yael Swica, Michelle P Warren, JoAnn E Manson, Aaron K Aragaki, Shari S Bassuk, Daichi Shimbo, Andrew Kaunitz, Jacques Rossouw, Marcia L Stefanick, Catherine R Womack
OBJECTIVE: The aim of the study was to determine the effect of menopausal hormone therapy on incident hypertension in the two Women's Health Initiative hormone therapy trials and in extended postintervention follow-up. METHODS: A total of 27,347 postmenopausal women aged 50 to 79 years were enrolled at 40 US centers. This analysis includes the subsample of 18,015 women who did not report hypertension at baseline and were not taking antihypertensive medication. Women with an intact uterus received conjugated equine estrogens (CEE; 0...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381665/what-s-in-a-name-are-menopausal-hot-flashes-a-symptom-of-menopause-or-a-manifestation-of-neurovascular-dysregulation
#14
Virginia M Miller, Juliana M Kling, Julia A Files, Michael J Joyner, Ekta Kapoor, Ann M Moyer, Walter A Rocca, Stephanie S Faubion
Hot flashes have typically been classified as "symptoms of menopause" that should be tolerated or treated until they resolve. However, mounting evidence points to hot flashes as a manifestation of one or several underlying pathophysiological processes. Associations exist between the presence, timing of onset, severity, and duration of hot flashes, and the risk of several neurological (affecting sleep, mood, and cognition) and cardiovascular conditions. In addition, four consistent patterns of vasomotor disturbances have been identified across different countries, making it unlikely that these patterns are solely explained by socioeconomic or cultural factors...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381664/hormone-therapy-and-urine-protein-excretion-a-multiracial-cohort-study-systematic-review-and-meta-analysis
#15
Andrea G Kattah, Maria L G Suarez, Natasa Milic, Kejal Kantarci, Burcu Zeydan, Thomas Mosley, Stephen T Turner, Erin B Ware, Sharon L R Kardia, Vesna D Garovic
OBJECTIVE: Experimental models suggest estrogen has a renoprotective effect, but human studies show variable results. Our objective was to study the association of hormone therapy (HT) and albuminuria in postmenopausal women and to synthesize the results with outcomes from prior studies. METHODS: We analyzed data from postmenopausal women who participated in the second study visit (2000-2004) of the Genetic Epidemiology Network of Arteriopathy (GENOA) study. The exposure was self-reported HT use and the outcome was albuminuria (urine albumin-to-creatinine ratio >25 mg/g creatinine)...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381663/the-women-s-health-initiative-addressing-vaginal-and-sexual-health
#16
Gloria Bachmann, Nancy Phillips
No abstract text is available yet for this article.
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381662/association-between-hiv-status-and-psychological-symptoms-in-perimenopausal-women
#17
Sara E Looby, Christina Psaros, Greer Raggio, Corinne Rivard, Laura Smeaton, Jan Shifren, Steven Grinspoon, Hadine Joffe
OBJECTIVE: HIV-infected women are burdened by depression and anxiety, which may impact adherence to antiretroviral therapy and overall quality of life. Yet, little is known about the scope of psychological symptoms in the growing number of HIV-infected women reaching menopause, when affective symptoms are more prevalent in the general population. We conducted a longitudinal study to compare affective symptoms between perimenopausal HIV-infected and non-HIV-infected women. METHODS: The Center for Epidemiologic Studies Depression Scale (CES-D), and the Generalized Anxiety Disorder scale (GAD-7) were completed at baseline and 12 months among 33 HIV-infected and 33 non-HIV-infected perimenopausal women matched by race, age, menstrual patterns, and BMI...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381661/perspectives-and-decision-making-about-menopausal-therapies-in-women-who-had-bilateral-oophorectomy
#18
Tasneem Siyam, Sue Ross, Tami Shandro, Shelly Hagen, Lori Battochio, Nesé Yuksel
OBJECTIVE: The aim of the study was to explore the process of decision-making about menopausal treatments in women who have had surgical menopause as a result of bilateral oophorectomy (≤50 y). METHODS: We used a descriptive qualitative research design. Women who had a surgical menopause were purposefully selected from the Edmonton Menopause Clinics. Focus groups were held, each with six to nine participants. All sessions were audio-recorded and transcribed verbatim...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29381660/prevalence-of-hormone-therapy-factors-associated-with-its-use-and-knowledge-about-menopause-a-population-based-household-survey
#19
Poliana Pacello, Luiz F Baccaro, Adriana O Pedro, Lucia Costa-Paiva
OBJECTIVE: The aim of the study was to assess the prevalence of hormone therapy (HT), the factors associated with its use, and the importance of knowledge about menopause and HT. METHODS: A cross-sectional population-based study with 749 Brazilian women aged 45 to 60 years living in the Campinas Metropolitan Region was carried out between September 2012 and June 2013. The dependent variable was current or previous HT use. The independent variables were sociodemographic data, health-related problems, and knowledge about menopause assessed using a score that was obtained with a questionnaire on various aspects of menopause...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29360704/association-between-insulin-resistance-and-the-magnetic-resonance-spectroscopy-determined-marrow-fat-fraction-in-nondiabetic-postmenopausal-women
#20
Guanwu Li, Zheng Xu, Haiyang Lin, Yilei Chen, Xuefeng Li, Shixin Chang
OBJECTIVE: The clinical consequences of insulin resistance and hyperinsulinemia on marrow lipid remain elusive. We aimed to explore the effects of anthropometric and biochemical measures, that is, estimates of insulin resistance, on marrow lipid accumulation in nondiabetic postmenopausal women using magnetic resonance (MR) spectroscopy. METHODS: The study participants were 91 nondiabetic postmenopausal women. Marrow fat fraction (FF) at the L3 vertebral body by single-voxel MR spectroscopy and bone mineral density (BMD) by dual-energy x-ray absorptiometry were measured...
January 22, 2018: Menopause: the Journal of the North American Menopause Society
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