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Menopause: the Journal of the North American Menopause Society

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https://www.readbyqxmd.com/read/30649087/polycystic-ovary-syndrome-is-the-cardiometabolic-risk-increased-after-menopause
#1
Snigdha Alur-Gupta, Anuja Dokras
Although more commonly known for its fertility sequelae, dermatologic, metabolic, and psychological morbidities associated with polycystic ovary syndrome (PCOS) are not well recognized. This Practice Pearl reviews the effect of PCOS on cardiometabolic risk during the reproductive years and the consequence of these findings in middle-aged women. Current screening and management recommendations are reviewed.
January 14, 2019: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30649086/relationships-between-menopausal-symptoms-sense-of-coherence-coping-strategies-and-quality-of-life
#2
Fei Wan Ngai
OBJECTIVES: The aims of this study were to examine the relationships between menopausal symptoms, sense of coherence (SOC), coping strategies, and quality of life, and to test the mediating effects of SOC and coping strategies on the relationships between menopausal symptoms and quality of life among Chinese women during menopausal transition. METHODS: Two hundred one women aged 40 to 60 years and currently undergoing menopausal transition were recruited at community centers between June and August 2017...
January 14, 2019: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30649085/the-effects-of-genetic-variants-related-to-insulin-metabolism-pathways-and-the-interactions-with-lifestyles-on-colorectal-cancer-risk
#3
Su Yon Jung, Zuo-Feng Zhang
OBJECTIVES: Genetic variants in metabolic signaling pathways may interact with lifestyle factors, such as dietary fatty acids, influencing postmenopausal colorectal cancer (CRC) risk, but these interrelated pathways are not fully understood. METHODS: In this study, we examined 54 single-nucleotide polymorphisms (SNPs) in genes related to insulin-like growth factor-I/insulin traits and their signaling pathways and lifestyle factors in relation to postmenopausal CRC, using data from 6,539 postmenopausal women in the Women's Health Initiative Harmonized and Imputed Genome-Wide Association Studies...
January 14, 2019: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30640806/rethinking-the-techno-vagina-a-case-series-of-patient-complications-following-vaginal-laser-treatment-for-atrophy
#4
Catherine Gordon, Savanah Gonzales, Michael L Krychman
OBJECTIVE: The treatment of genitourinary syndrome of menopause (GSM) includes prescription hormone therapy, nonhormonal over-the-counter products, and most recently, laser treatment. Although the Food and Drug Administration has cleared fractional carbon dioxide (CO2) laser for a variety of dermatologic and gynecologic indications, lasers have not to date, been approved for use for vulvar/vaginal atrophy, or sexual dysfunction. METHODS: Four case studies that were referred to a tertiary sexual medicine center regarding laser treatment complications for GSM are reported...
January 4, 2019: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30601454/persistent-vasomotor-symptoms-and-breast-cancer-in-the-women-s-health-initiative
#5
Rowan T Chlebowski, Joanne E Mortimer, Carolyn J Crandall, Kathy Pan, JoAnn E Manson, Rebecca Nelson, Karen C Johnson, Mara Z Vitolin, Dorothy Lane, Jean Wactawski-Wende, Karen Kwan, Marcia L Stefanick
OBJECTIVE: Vasomotor symptoms (VMS) including hot flashes and night sweats are common during the menopausal transition and may persist. Although VMS pathophysiology is complex, estrogen's efficiency as VMS therapy suggests hormonal environment change may influence this process. As studies of VMS and breast cancer are inconsistent, we examined associations between persistent VMS and breast cancer incidence and mortality. METHODS: The analytic sample included 25,499 postmenopausal women aged 50 to 79 in the Women's Health Initiative (WHI) without current/former menopausal hormone therapy use with information on VMS status (never vs persistent)...
December 28, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30601453/genitourinary-syndrome-of-menopause-symptom-severity-and-impact-outcome-measures-are-they-reliable-and-correlated
#6
Joanie Mercier, Mélanie Morin, Barbara Reichetzer, Marie-Claude Lemieux, Samir Khalifé, Chantale Dumoulin
OBJECTIVE: The Most Bothersome Symptom Approach (MBSA) assesses symptom severity of genitourinary syndrome of menopause (GSM), and identifies the symptom with the greatest burden. The Atrophy Symptoms Questionnaire (ASQ) assesses the impact of GSM symptoms on the activities of daily living. The psychometric properties of these outcomes remain to be completely assessed. This study aimed to assess the test-retest reliability of the MBSA and the ASQ and their convergent validity. METHOD: One evaluator administered the outcomes twice 2 weeks apart to postmenopausal women with GSM and urinary incontinence...
December 28, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30601452/relationship-between-vasomotor-symptom-improvements-and-quality-of-life-and-sleep-outcomes-in-menopausal-women-treated-with-oral-combined-17%C3%AE-estradiol-progesterone
#7
Sebastian Mirkin, Shelli Graham, Dennis A Revicki, Randall H Bender, Brian Bernick, Ginger D Constantine
OBJECTIVE: To characterize the impact of TX-001HR on the relationship between vasomotor symptom (VMS) improvement and quality of life and sleep. METHODS: REPLENISH (NCT01942668) was a phase 3, randomized, double-blind, placebo-controlled, multicenter trial, which evaluated four daily doses of 17β-estradiol and progesterone (E2/P4) combined in a single, oral, softgel capsule in postmenopausal women (40-65 years) with a uterus and moderate to severe VMS (≥7/day or ≥50/week)...
December 28, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30586007/knee-osteoarthritis-and-menopausal-hormone-therapy-in-postmenopausal-women-a-nationwide-cross-sectional-study
#8
Jae Hyun Jung, Cho Hee Bang, Gwan Gyu Song, Cholhee Kim, Jae-Hoon Kim, Sung Jae Choi
OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012)...
December 21, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30586006/gastric-responses-to-acute-psychological-stress-in-climacteric-women-a-pilot-study
#9
María Raquel Huerta-Franco, Miguel Vargas-Luna, Ximena Somoza, Isabel Delgadillo-Holtfort, Marco Balleza-Ordaz, Svetlana Kashina
OBJECTIVE: Women exhibit reduced ovarian sex hormones during the menopausal period that result in well-known physical and psychological symptoms. However, symptoms related to gastric motility (GM) have not been thoroughly investigated. We hypothesized that stress response gastric motility (SRGM) is lower in postmenopausal (PM) and perimenopausal (PERIM) women than in premenopausal (PREM) women. Estrogenic decline leads to neuroendocrine changes in different areas of the brain. These changes can result in hypothalamic vasomotor symptoms, disorders in eating behaviours, and altered blood pressure, in addition to psychological disorders such as stress, anxiety, depression, and irritability related to alterations in the limbic system...
December 21, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30586005/improvement-in-sleep-outcomes-with-a-17%C3%AE-estradiol-progesterone-oral-capsule-tx-001hr-for-postmenopausal-women
#10
Risa Kagan, Ginger Constantine, Andrew M Kaunitz, Brian Bernick, Sebastian Mirkin
OBJECTIVE: The aim of the study was to evaluate the effects of TX-001HR, a single-capsule 17β-estradiol-progesterone on sleep parameters in postmenopausal women with vasomotor symptoms (VMS) using the Medical Outcomes Study (MOS)-Sleep scale questionnaire in the REPLENISH trial. METHODS: In the REPLENISH trial (NCT01942668), women were randomized to one of four doses of TX-001HR or placebo, and the 12-item MOS-Sleep questionnaire (secondary endpoint) was self-administered at baseline, week 12, and months 6 and 12...
December 21, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30586004/menopausal-hormone-therapy-trends-before-versus-after-2002-impact-of-the-women-s-health-initiative-study-results
#11
Sybil L Crawford, Carolyn J Crandall, Carol A Derby, Samar R El Khoudary, L Elaine Waetjen, Mary Fischer, Hadine Joffe
OBJECTIVE: To better understand how to educate patients and providers about study findings relevant to treatment guidelines, we assessed pre- versus post-Women's Health Initiative (WHI) differences in menopausal hormone therapy (MHT) initiation and continuation and their correlates, and in women's reasons for initiation and discontinuation. METHODS: We analyzed survey data from up to 14 approximately annual visits over 17 years (1996-2013) from 3,018 participants in the Study of Women's Health Across the Nation, a prospective cohort study...
December 21, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30586003/menopausal-symptoms-not-just-estrogen-deficiency
#12
Amnon Brzezinski
No abstract text is available yet for this article.
December 21, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562323/the-unintended-sexual-health-consequences-of-risk-reducing-surgery-we-must-do-more
#13
Lisa Larkin, Sheryl A Kingsberg
No abstract text is available yet for this article.
December 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562322/the-effects-of-swimming-training-on-arterial-function-muscular-strength-and-cardiorespiratory-capacity-in-postmenopausal-women-with-stage-2-hypertension
#14
Alexei Wong, Yi-Sub Kwak, Steven D Scott, Elizabeth J Pekas, Won-Mok Son, Ji-Seok Kim, Song-Young Park
OBJECTIVE: Aging is associated with progressive decreases in arterial health as well as muscular strength and cardiorespiratory capacity. It is crucial to prevent or reduce the negative effects of aging on vasculature, muscular, and cardiorespiratory function by implementing appropriate lifestyle interventions, such as exercise training. We examined the effects of a swimming (SWM) regimen on arterial stiffness (pulse wave velocity [PWV]), blood pressure (BP), wave reflection (augmentation index [AIx]), muscle strength, and aerobic capacity in sedentary, postmenopausal women with stage 2 hypertension...
December 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562321/therapeutic-effects-of-whole-body-vibration-on-fracture-healing-in-ovariectomized-rats-a-systematic-review-and-meta-analysis
#15
Jinman Chen, Hongfeng Ruan, Yang Liu, Jiamin Bao, Hao Xu, Min Yao, Xuejun Cui, Qianqian Liang, Yongjun Wang
OBJECTIVE: Whole-body vibration (WBV), providing cyclic mechanical stimulation, has been used to accelerate fracture healing in preclinical studies. This study aimed to summarize and evaluate the effects of WBV on bone healing in ovariectomized rat models and then analyze its potential effects on fractures in human postmenopausal osteoporosis. METHODS: PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, VIP, SinoMed, and WanFang databases were searched from their inception date to September 2017, and an updated search was conducted in January 2018...
December 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562320/vaginal-estrogen-use-and-chronic-disease-risk-in-the-nurses-health-study
#16
Shilpa N Bhupathiraju, Francine Grodstein, Meir J Stampfer, Walter C Willett, Carolyn J Crandall, Jan L Shifren, JoAnn E Manson
OBJECTIVE: To examine the associations between vaginal estrogen use and multiple health outcomes including cardiovascular disease (total myocardial infarction, stroke, and pulmonary embolism/deep vein thrombosis), cancer (total invasive, breast, endometrial, ovarian, and colorectal cancer), and hip fracture. METHODS: We included postmenopausal women from the Nurses' Health Study (1982-2012) who were not current users of systemic hormone therapy at the start of the study or during follow-up...
December 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562319/the-experiences-and-needs-of-asian-women-experiencing-menopausal-symptoms-a-meta-synthesis
#17
Shefaly Shorey, Esperanza D Ng
OBJECTIVE: The aim of the study was to explore the experiences and needs of Asian women who were experiencing or had experienced menopause and to determine possible differences in experiences due to acculturation by comparing Asian women living in Asia and those living in Western countries. METHODS: Six electronic databases were systematically searched: PubMed, CINAHL, Embase, Scopus, PsycINFO, and ProQuest. The search resulted in 17 qualitative studies that met the inclusion and exclusion criteria...
December 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562318/vaginal-ring-pessary-use-for-pelvic-organ-prolapse-continuation-rates-and-predictors-of-continued-use
#18
Jittima Manonai, Sirirat Sarit-Apirak, Umaporn Udomsubpayakul
OBJECTIVES: The aim of the study was (1) to evaluate continuation rates of vaginal ring pessary for pelvic organ prolapse (POP), and (2) to identify predictors for continued pessary use. METHODS: This retrospective chart review study was conducted in a tertiary center. Women who had a ring with support pessary successfully fitted between January 2009 and December 2013 and had completed up to 3 years of follow-up care were included in the analysis. Demographic and obstetric data, body weight, pelvic organ prolapse stage, and associated symptoms were evaluated...
December 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562317/age-at-menarche-and-risk-of-all-cause-and-cardiovascular-mortality-a-systematic-review-and-dose-response-meta-analysis
#19
Xu Chen, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Xuejiao Liu, Dongdong Zhang, Cheng Cheng, Leilei Liu, Feiyan Liu, Qionggui Zhou, Chongjian Wang, Linlin Li, Bingyuan Wang, Yang Zhao, Dechen Liu, Ming Zhang, Dongsheng Hu
OBJECTIVE: The evidence between age at menarche and mortality risk is controversial. We aimed to quantify the dose-response association of age at menarche and risk of all-cause and cardiovascular disease (CVD) mortality based on cohort studies. METHODS: PubMed, EMBASE, Web of Science, and Scopus databases were searched up to March 15, 2018 for relevant articles. Random-effects models and restricted cubic splines were used for this meta-analysis. RESULTS: Twelve cohort studies, with 79,363 deaths and 2,341,769 participants, met the inclusion criteria...
December 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30562316/follicle-stimulating-hormone-is-associated-with-lipids-in-postmenopausal-women
#20
Corinna Serviente, Tomi-Pekka Tuomainen, Jyrki Virtanen, Sarah Witkowski, Leo Niskanen, Elizabeth Bertone-Johnson
OBJECTIVE: The purpose of this study was to evaluate the relation between FSH and lipid levels in postmenopausal women from the Kuopio Ischaemic Heart Disease Risk Factor Study. METHODS: Postmenopausal women (n = 588) aged 53 to 73 years and not using hormone therapy were included. The relation between FSH and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) was evaluated using linear regression, adjusting for estradiol, body mass, smoking, and other hormonal and lifestyle factors...
December 17, 2018: Menopause: the Journal of the North American Menopause Society
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