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Menopause: the Journal of the North American Menopause Society

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https://www.readbyqxmd.com/read/30234731/appropriate-evaluation-of-postmenopausal-bleeding
#1
Steven R Goldstein
: In clinical practice, although only 3% to 7% of women with postmenopausal bleeding (PMB) will ultimately be found to have cancer, it is the clinician's responsibility to ensure that endometrial cancer is not present. The diagnostic evaluation of PMB has evolved greatly. This Practice Pearl addresses the appropriate evaluation of women with PMB.
September 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30234730/low-pretreatment-serum-concentration-of-vitamin-d-at-breast-cancer-diagnosis-in-postmenopausal-women
#2
Murilo Renato Matos Machado, Benedito de Sousa Almeida-Filho, Heloisa De Luca Vespoli, Eneida Boteon Schmitt, Jorge Nahas-Neto, Eliana A P Nahas
OBJECTIVE: The aim of the study was to evaluate the rate of and risk factors for low pretreatment vitamin D (VitD) levels in postmenopausal breast cancer (BC) women, compared with postmenopausal women without BC. METHODS: A cross-sectional clinical study was conducted to compare 209 women with BC (case group) to 418 women without BC (control group), age range: 45 to 75 years. The case group consisted of women diagnosed with BC, amenorrhea ≥12 months, aged ≥45 years, without use of medication or clinical conditions that might interfere with VitD levels...
September 17, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30204640/to-the-editor
#3
Yona Tadir
No abstract text is available yet for this article.
September 10, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30204639/in-reply
#4
Stephanie S Faubion, Lisa C Larkin, James A Simon, Sheryl A Kingsberg
No abstract text is available yet for this article.
September 10, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30188331/inter-relationship-between-diet-lifestyle-habits-gut-microflora-and-the-equol-producer-phenotype-baseline-findings-from-a-placebo-controlled-intervention-trial
#5
Remi Yoshikata, Khin Z Myint, Hiroaki Ohta, Yoko Ishigaki
OBJECTIVE: Equol is an active metabolite of isoflavones produced by gut microbiota. It is beneficial to health; however, equol-producing ability varies greatly among individuals. These variations depend on the host's gut microbiota and lifestyle habits including diet. We investigated the relationship between the gut microbiota, lifestyle habits including diet, and equol-producing ability in postmenopausal Japanese women. METHODS: We studied 58 postmenopausal Japanese women aged 48 to 69 years who visited the Sendai Medical Center in January, 2018...
September 4, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30153218/clinician-knowledge-attitudes-and-barriers-to-management-of-vulvovaginal-atrophy-variations-in-primary-care-and-gynecology
#6
Kimberly K Vesco, Kate Beadle, Ashley Stoneburner, Joanna Bulkley, Michael C Leo, Amanda L Clark
OBJECTIVE: Vulvovaginal atrophy is a common, but under-recognized condition affecting postmenopausal women. To guide development of an intervention to boost its detection and treatment, we surveyed primary care and gynecology clinicians practicing in an integrated healthcare system. METHODS: We constructed a three-part survey that contained (1) eight multiple-choice knowledge questions; (2) three Likert-scale questions regarding clinicians' likelihood of assessing for vulvovaginal atrophy symptoms at a routine (well) visit, confidence in advising patients about symptoms and counseling about therapy; and (3) a 12-item check list of potential barriers to diagnosis and treatment...
August 27, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30153217/amenorrhea-after-lung-cancer-treatment
#7
Elizabeth J Cathcart-Rake, Kathryn J Ruddy, Ruchi Gupta, Walter Kremers, Kelly Gast, H Irene Su, Ann H Partridge, Elizabeth A Stewart, Han Liu, Yanqi He, Ping Yang
OBJECTIVE: More than 5,000 premenopausal women are diagnosed with lung cancer annually in the United States. Limited data exist regarding the risk of treatment-related amenorrhea, a surrogate for infertility and early menopause, after systemic therapies for lung cancer. METHODS: Premenopausal women diagnosed with lung cancer under age 50 were surveyed at diagnosis and annually thereafter about their menstrual status as a part of the Mayo Clinic Epidemiology and Genetics of Lung Cancer Research Program...
August 27, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30153216/changes-in-adiposity-and-other-factors-in-relation-to-age-at-natural-menopause-analyses-from-the-coronary-artery-risk-development-cardia-study
#8
Christy Costanian, Hugh McCague, Heather Edgell, Chris I Ardern, Hala Tamim
OBJECTIVE: The age at natural menopause has subsequent health implications. Earlier age at natural menopause is a risk factor for cardiovascular disease, atherosclerosis, and stroke. Despite extensive study, no clear and conclusive association between anthropometric measures and age at natural menopause has emerged. This study aims to assess whether baseline and/or longitudinal changes in adiposity are associated with age at natural menopause. METHODS: In all, 2,030 premenopausal women from the Coronary Artery Risk Development in Young Adults study-a prospective study with 25 years follow-up-were included for analysis from 1985 to 1986 until menopause was attained...
August 27, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130293/wisdom-survey-attitudes-and-behaviors-of-physicians-toward-vulvar-and-vaginal-atrophy-vva-treatment-in-women-including-those-with-breast-cancer-history
#9
Sheryl A Kingsberg, Lisa Larkin, Michael Krychman, Sharon J Parish, Brian Bernick, Sebastian Mirkin
OBJECTIVE: To evaluate and compare physicians' behaviors and attitudes regarding vulvar and vaginal atrophy (VVA) treatment in menopausal women, including women with breast cancer, using an internet-based survey. METHODS: The WISDOM survey queried obstetricians and gynecologists (OB/GYNs) and primary care physicians (PCPs) with 23 multipart questions assessing behaviors and attitudes towards VVA treatment. RESULTS: Of 2,424 surveys sent, 945 (39%) responded and 644 (27%) were completed...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130292/successful-long-term-use-of-gellhorn-pessary-and-the-effect-on-symptoms-and-quality-of-life-in-women-with-symptomatic-pelvic-organ-prolapse
#10
Meng Mao, Fangfang Ai, Jia Kang, Ye Zhang, Shuo Liang, Ying Zhou, Lan Zhu
OBJECTIVE: To evaluate the long-term continuation rate of the Gellhorn pessary and its effect on bothersome symptoms and quality of life (QOL) in women with symptomatic pelvic organ prolapse (POP). METHODS: This was a prospective observational study. Ninety-one women with symptomatic POP were successfully fitted with Gellhorn pessaries (short stem) between June, 2015 and January, 2017. The participants were monitored at 3 and 6 months, and also every 6 months afterwards until February, 2018...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130291/association-of-menopause-and-type-2-diabetes-mellitus
#11
Yongcheng Ren, Ming Zhang, Yu Liu, Xizhuo Sun, Bingyuan Wang, Yang Zhao, Dechen Liu, Xuejiao Liu, Dongdong Zhang, Feiyan Liu, Cheng Cheng, Leilei Liu, Xu Chen, Qionggui Zhou, Dongsheng Hu
OBJECTIVE: Limited information is available on the direct effect of menopause and risk of type 2 diabetes mellitus (T2DM) among women with different metabolic types. We aimed to investigate whether menopause is a direct risk factor for T2DM. METHODS: In this population-based cross-sectional study, women were recruited from a rural area of China from July to August 2013 and July to August 2014. Multivariate logistic regression analysis yielded adjusted odds ratios (ORs) and 95% CIs...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130290/bazedoxifene-induced-vasodilation-and-inhibition-of-vasoconstriction-is-significantly-greater-than-estradiol
#12
Margaret A Zimmerman, Dillion D Hutson, Franck Mauvais-Jarvis, Sarah H Lindsey
OBJECTIVE: A new strategy for menopausal hormone therapy replaces medroxyprogesterone with the selective estrogen receptor modulator bazedoxifene. While the agonist or antagonist activity of bazedoxifene has been examined in other tissues, the current study explored the impact of bazedoxifene on resistance artery reactivity. We hypothesized that bazedoxifene may induce greater vasoprotective effects than estradiol due to enhanced activation of the G-protein-coupled estrogen receptor. METHODS: We measured the vasodilation of mesenteric resistance arteries from adult male and female wild-type and G-protein-coupled estrogen receptor knockout mice (n = 58) in response to increasing concentrations of bazedoxifene, medroxyprogesterone, and estradiol, and also the impact of these compounds on the responses to phenylephrine and sodium nitroprusside...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130289/in-reply
#13
Meriem Koual, Anne-Sophie Bats, Fabrice Lécuru
No abstract text is available yet for this article.
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130288/to-the-editor
#14
Martha Hickey, Jennifer Marino
No abstract text is available yet for this article.
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130287/in-reply
#15
Stephanie S Faubion, Lisa C Larkin, Michael L Krychman, Sheryl A Kingsberg
No abstract text is available yet for this article.
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130286/factors-associated-with-age-at-natural-menopause-among-elderly-women-in-s%C3%A3-o-paulo-brazil
#16
Alejandra Andrea Roman Lay, Yeda Aparecida de Oliveira Duarte, Alexandre Dias Porto Chiavegatto Filho
OBJECTIVES: To analyze factors associated with age at natural menopause in elderly women who are part of the Health, Well-Being and Aging Study- which is a representative sample of elderly residents of the municipality of São Paulo, Brazil. METHODS: Multivariate Cox proportional-hazards analysis using data from a total of 1,415 women with natural menopause. We included 163 women with hysterectomy, oophorectomy, and estrogen therapy as censored data. RESULTS: The median age of natural menopause was 50 years...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130285/status-of-bone-strength-and-factors-associated-with-vertebral-fracture-in-postmenopausal-women-with-type-2-diabetes
#17
Fang-Ping Chen, Sheng-Fong Kuo, Yu-Ching Lin, Chih-Ming Fan, Jung-Fu Chen
OBJECTIVE: The aim of this study was to assess the status of bone mass, microarchitecture, and factors associated with vertebral fracture in postmenopausal women with type 2 diabetes mellitus (T2DM). METHODS: We consecutively enrolled 285 women (aged 60.7 ± 6.9 y) with T2DM who underwent bone mineral density (BMD) and trabecular bone score (TBS) assessment using dual-energy x-ray absorptiometry; T8-S1 lateral spine radiographs; laboratory evaluation; and interviews regarding clinical risk factors based on the fracture risk assessment tool (FRAX)...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130284/hormone-therapy-in-postmenopausal-women-associated-with-risk-of-stroke-and-venous-thromboembolism-a-population-based-cohort-study-in-taiwan
#18
Wei-Chuan Chang, Jen-Hung Wang, Dah-Ching Ding
OBJECTIVE: The aim of the study was to evaluate the risks and benefits of hormone therapy (HT) in postmenopausal women in Taiwan. METHODS: A retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database, a population-based healthcare claims dataset. Eligible women, aged 40 to 65, were matched 1:1 by age and menopause year to avoid confounding through imbalanced baseline characteristics among the two groups (2,491 pairs). The primary outcomes were acute coronary syndrome (ACS), venous thromboembolism (VTE), and ischemic stroke (IS)...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30130283/intracrinology-and-menopause-the-science-describing-the-cell-specific-intracellular-formation-of-estrogens-and-androgens-from-dhea-and-their-strictly-local-action-and-inactivation-in-peripheral-tissues
#19
Fernand Labrie
The secretion of estrogens by the ovaries stops at menopause. Afterward, dehydroepiandrosterone (DHEA) becomes the only source of both estrogens and androgens during all the postmenopausal years. To maintain very low and biologically inactive concentrations of estrogens and androgens in the circulation, DHEA is transformed intracellularly into cell-specific small amounts of estrogens and androgens (except in the endometrium) which then act and are inactivated locally in the same cells, thus avoiding biologically significant systemic exposure to active sex steroids...
August 20, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30085981/validation-of-the-10-item-cervantes-scale-in-middle-aged-portuguese-women-paper-and-pencil-and-online-format-assessment-of-menopause-related-symptoms
#20
Filipa Pimenta, Rita Albergaria, João Marôco, Isabel Leal, Peter Chedraui, Faustino R Pérez-López
OBJECTIVE: The aim of the study was to validate the Portuguese language version of the 10-item Cervantes Scale (CS-10), a self-reporting instrument that assesses menopausal symptoms, and to compare the results (both symptom severity and multigroup invariance) of middle-aged women who completed the questionnaire in paper-and-pencil format (PPF) or in the online format (OF). METHODS: A total of 292 women, aged 45 to 65 years, completed the questionnaires (PPF = 66; OF = 226)...
August 6, 2018: Menopause: the Journal of the North American Menopause Society
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