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Canadian Respiratory Journal: Journal of the Canadian Thoracic Society

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https://www.readbyqxmd.com/read/29093631/the-effect-of-mechanical-ventilation-on-task-1-expression-in-the-brain-in-a-rat-model
#1
Buqi Na, Hong Zhang, Guangfa Wang, Li Dai, Guoguang Xia
Background and Objective: TWIK-related acid-sensitive potassium channel 1 (TASK-1) is closely related to respiratory central control and neuronal injury. We investigated the effect of MV on TASK-1's functions and explored the mechanism using a rat model. Methods: Male Sprague-Dawley rats were randomized to three groups: (1) high tidal volume (HVt): MV for four hours with Vt at 10 mL/kg; (2) low Vt (LVt): MV for four hours with Vt at 5 mL/kg; (3) basal (BAS): anesthetized and unventilated animals...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29089817/rainfall-associated-bronchospasm-epidemics-the-epidemiological-effects-of-air-pollutants-and-weather-variables
#2
Kambiz Masoumi, Maryam Haddadzadeh Shoushtari, Arash Forouzan, Ali Asgari Darian, Maryam Dastoorpoor, Pegah Ebrahimzadeh, Hamidreza Aghababaeian
BACKGROUND: This study compares different risk factors in patients visiting a hospital during five rainfall-associated bronchospasm epidemics in Ahvaz and those visiting on other occasions. METHODS: This case-control study was conducted on 5307 patients with bronchospasm admitted to the Emergency Department of Imam Khomeini Hospital in Ahvaz (Iran) from late October to December (as the epidemic) and 916 patients admitted from late January to March (as the nonepidemic) in 2011 to 2015...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29089816/impaired-hemorheology-in-exacerbations-of-copd
#3
Erhan Ugurlu, Emine Kilic-Toprak, Ilknur Can, Ozgen Kilic-Erkek, Goksel Altinisik, Melek Bor-Kucukatay
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. MATERIALS AND METHODS: The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29081679/occupational-exposure-to-talc-increases-the-risk-of-lung-cancer-a-meta-analysis-of-occupational-cohort-studies
#4
REVIEW
Che-Jui Chang, Yu-Kang Tu, Pau-Chung Chen, Hsiao-Yu Yang
OBJECTIVE: Talc is widely used in industrial applications. Previous meta-analyses of carcinogenic effects associated with inhaled talc included publications before 2004, with a lack of data in China, the largest talc-producing country. The safety of workers exposed to talc was unclear due to limited evidence. The objective of this study was to reevaluate the association between inhaled talc and lung cancer. SETTING PARTICIPANTS AND OUTCOME MEASURES: A meta-analysis was performed to calculate the meta-SMR of lung cancer...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28951662/safety-and-performance-characteristics-of-outpatient-medical-thoracoscopy-and-indwelling-pleural-catheter-insertion-for-evaluation-and-diagnosis-of-pleural-disease-at-a-tertiary-center-in-canada
#5
Robert Kyskan, Pen Li, Sunita Mulpuru, Carolina Souza, Kayvan Amjadi
BACKGROUND: Many centers performing medical thoracoscopy (MT) to diagnose pleural disease will insert a chest tube and admit patients to hospital after the procedure, which is inconvenient for patients and contributes to healthcare costs. We report the data on the safety, outcomes, and performance characteristics of outpatient MT with indwelling pleural catheter (IPC) insertion in a large Canadian cohort. METHODS: This retrospective cohort study reviewed patients who underwent outpatient MT and IPC insertion under conscious sedation...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28951661/mechanical-circulatory-support-as-a-bridge-to-lung-transplantation-a-single-canadian-institution-review
#6
Katie Kinaschuk, Sabin J Bozso, Kieran Halloran, Ali Kapasi, Kathy Jackson, Jayan Nagendran
BACKGROUND: Lung transplant (LTx) waitlists continue to grow internationally. Consequently, more patients are progressing to require mechanical circulatory support (MCS) as a bridge to transplantation (BTT). MCS strategies include interventional lung assist (iLA) and venovenous (VV) and venoarterial (VA) extracorporeal membrane oxygenation (ECMO). We review our series of patients bridged with MCS while listed for LTx. METHODS: All consecutive patients, listed for LTx requiring MCS as a BTT at the University of Alberta from 2004 to 2015, were included...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28947874/readability-and-suitability-of-copd-consumer-information
#7
Kathryn Fullmann, David F Blackburn, Mark E Fenton, Holly Mansell
BACKGROUND: Information leaflets have been shown to positively or negatively impact adherence, depending on their content. The objective of this study was to perform an appraisal of the consumer information provided in COPD inhaler monographs. METHODS: COPD inhalers were identified from the Health Canada Drug Product Database. Medication information and instructions for inhaler use were analyzed for readability by seven formulas, with an acceptability threshold of grades 6-8...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28932130/pulmonary-hypertension-due-to-lung-diseases-and-or-hypoxia-what-do-we-actually-know
#8
EDITORIAL
Djuro Kosanovic, Emilio A Herrera, Akylbek Sydykov, Stylianos E Orfanos, Elie El Agha
No abstract text is available yet for this article.
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28848370/preliminary-results-of-the-adoption-and-application-of-the-integrated-comprehensive-care-bundle-care-program-when-treating-patients-with-chronic-obstructive-pulmonary-disease
#9
Jason R Guertin, James M Bowen, Carolyn Gosse, Gord Blackhouse, Daria J O'Reilly, Emanuel Baltaga, Gerard Cox, Donna Johnson, Brandi Le Blanc, Jane Loncke, Stewart Pugsley, Ravi Sivakumaran, Laura Wheatley, Kevin Smith, Jean-Eric Tarride
BACKGROUND: St. Joseph's Health System has implemented an integrated comprehensive care bundle care (ICC) program with the hopes that it would improve patients' care while reducing overall costs. The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary obstructive disease (COPD). METHODS: We conducted a retrospective observational cohort study comparing ICC patients to non-ICC patients admitted to St...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28814914/body-height-of-children-with-bronchial-asthma-of-various-severities
#10
Tatiana I Eliseeva, Natalia A Geppe, Elena V Tush, Olga V Khaletskaya, Ivan I Balabolkin, Vilya A Bulgakova, Nailya I Kubysheva, Stanislav K Ignatov
Influence of bronchial asthma (BA) severity on physical development in children patients was evaluated in comparison with healthy population. Materials and Methods. 1042 children and adolescents (768 boys) with atopic BA were evaluated. All children underwent standard examination in a clinical setting, including anthropometry. The control group included 875 healthy children of a comparable age (423 boys). Results. The fraction of patients with the normal, lower, and increased height among the whole group of patients with BA is close to the corresponding values in the healthy population (χ(2) = 3...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28814913/right-ventricular-remodeling-and-dysfunction-in-obstructive-sleep-apnea-a-systematic-review-of-the-literature-and-meta-analysis
#11
REVIEW
Abdirashit Maripov, Argen Mamazhakypov, Meerim Sartmyrzaeva, Almaz Akunov, Kubatbek Muratali Uulu, Melis Duishobaev, Meerim Cholponbaeva, Akylbek Sydykov, Akpay Sarybaev
BACKGROUND: Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are lacking. METHODS: A comprehensive electronic database (PubMed, Web of Science, and Google Scholar) and reference search up to October 30, 2016, was performed. A systematic review and meta-analysis were performed to assess RV structure and function in OSA patients based on conventional echocardiography and tissue Doppler imaging...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28790878/investigating-cost-implications-of-incorporating-level-iii-at-home-testing-into-a-polysomnography-based-sleep-medicine-program-using-administrative-data
#12
Samuel Alan Stewart, Erika Penz, Mark Fenton, Robert Skomro
OBJECTIVE: Obstructive sleep apnea is a common problem, requiring expensive in-lab polysomnography for proper diagnosis. Home monitoring can provide an alternative to in-lab testing for a subset of OSA patients. The objective of this project was to investigate the effect of incorporating home testing into an OSA program at a large, tertiary sleep disorders centre. METHODS: The Sleep Disorders Centre in Saskatoon, Canada, has been incorporating at-home testing into their diagnostic pathways since 2006...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28717343/geographical-variation-and-factors-associated-with-non-small-cell-lung-cancer-in-manitoba
#13
David E Dawe, Harminder Singh, Lahiru Wickramasinghe, Marshall W Pitz, Mahmoud Torabi
BACKGROUND: Screening decreases non-small cell lung cancer (NSCLC) deaths and is recommended by the Canadian Task Force on Preventive Health Care. We investigated risk factor prevalence and NSCLC incidence at a small region level to inform resource allocation for lung cancer screening. METHODS: NSCLC diagnoses were obtained from the Canadian Cancer Registry, then geocoded to 283 small geographic areas (SGAs) in Manitoba. Sociodemographic characteristics of SGAs were obtained from the 2006 Canadian Census and Canadian Community Health Survey...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28713217/the-burden-of-illness-related-to-chronic-obstructive-pulmonary-disease-exacerbations-in-qu%C3%A3-bec-canada
#14
Tam Dang-Tan, Shiyuan Zhang, Ruben V Tavares, Melissa Stutz, Afisi S Ismaila, Julie Vaillancourt, Diane Corriveau, Richard H Stanford, Xiwu Lin, Gilbert A Nadeau, Alexander Simidchiev, Daria Parsons, John S Sampalis
BACKGROUND: Chronic obstructive pulmonary disease (COPD) prevalence in Canada has risen over time. COPD-related exacerbations contribute to the increased health care utilization (HCU) in this population. This study investigated the impact of exacerbations on COPD-related HCU. METHODS: This retrospective observational cohort study used patient data from the Québec provincial health insurance databases. Eligible patients with a new HCU claim with a diagnostic billing for COPD during 2001-2010 were followed until March 31, 2011...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28694713/an-algorithmic-approach-for-assessment-of-mediastinal-lesions-using-conventional-transbronchial-needle-aspiration-and-endoscopic-ultrasonography-in-a-single-procedure
#15
Andrew Burkett, Harmanjatinder S Sekhon, Craig Burkett, Shaheed W Hakim, Kayvan Amjadi
BACKGROUND: In the era of endobronchial/esophageal ultrasound (EBUS-TBNA/EUS-FNA), many centers forgo conventional transbronchial needle aspiration (C-TBNA) in favour of EBUS-TBNA/EUS-FNA despite no conclusive evidence showing better yields with EBUS-TBNA/EUS-FNA. OBJECTIVES: Assess the feasibility of an algorithmic approach for mediastinal sampling beginning with C-TBNA utilizing rapid onsite cytologic evaluation. METHODS: Descriptive analysis of 92 consecutive patients referred for adenopathy that underwent C-TBNA and subsequent EBUS-TBNA/EUS-FNA if C-TBNA was negative or nondiagnostic...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28680295/risk-factors-of-mortality-from-all-asbestos-related-diseases-a-competing-risk-analysis
#16
Rafael Abós-Herràndiz, Teresa Rodriguez-Blanco, Isabel Garcia-Allas, Isabel-Magdalena Rosell-Murphy, Constança Albertí-Casas, Josep Tarrés, Illona Krier-Günther, Xavier Martinez-Artés, Ramon Orriols, Isidre Grimau-Malet, Jaume Canela-Soler
BACKGROUND: The mortality from all malignant and nonmalignant asbestos-related diseases remains unknown. The authors assessed the incidence and risk factors for all asbestos-related deaths. METHODS: The sample included 544 patients from an asbestos-exposed community in the area of Barcelona (Spain), between Jan 1, 1970, and Dec 31, 2006. Competing risk regression through a subdistribution hazard analysis was used to estimate risk factors for the outcomes. RESULTS: Asbestos-related deaths were observed in 167 (30...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28630566/the-global-lung-function-initiative-2012-equations-are-as-well-suited-as-local-population-derived-equations-to-a-sample-of-healthy-professional-firefighters
#17
Flynn Slattery, Tjard Schermer, Adrian Esterman, Kylie Johnston, Alan Crockett
BACKGROUND AND OBJECTIVE: We aimed to assess the validity of using the Global Lung Function Initiative's (GLI) 2012 equations to interpret lung function data in a healthy workforce of South Australian Metropolitan Fire Service (SAMFS) personnel. METHODS: Spirometry data from 212 healthy, nonsmoking SAMFS firefighters were collected and predicted normal values were calculated using both the GLI and local population derived (Gore) equations for forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28630565/efficacy-of-various-scoring-systems-for-predicting-the-28-day-survival-rate-among-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-requiring-emergency-intensive-care
#18
Zhihong Feng, Tao Wang, Ping Liu, Sipeng Chen, Han Xiao, Ning Xia, Zhiming Luo, Bing Wei, Xiuhong Nie
We aimed to investigate the efficacy of four severity-of-disease scoring systems in predicting the 28-day survival rate among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) requiring emergency care. Clinical data of patients with AECOPD who required emergency care were recorded over 2 years. APACHE II, SAPS II, SOFA, and MEDS scores were calculated from severity-of-disease indicators recorded at admission and compared between patients who died within 28 days of admission (death group; 46 patients) and those who did not (survival group; 336 patients)...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28588383/comparison-of-different-disease-specific-health-related-quality-of-life-measurements-in-patients-with-long-term-noninvasive-ventilation
#19
Toru Oga, Hiroyuki Taniguchi, Hideo Kita, Tomomasa Tsuboi, Keisuke Tomii, Morihide Ando, Eiji Kojima, Hiromi Tomioka, Yoshio Taguchi, Yusuke Kaji, Ryoji Maekura, Toru Hiraga, Naoki Sakai, Tomoki Kimura, Michiaki Mishima, Wolfram Windisch, Kazuo Chin
BACKGROUND: Two disease-specific questionnaires have been developed to assess health-related quality of life (HRQL) in patients with chronic respiratory failure: the Severe Respiratory Insufficiency (SRI) Questionnaire and the Maugeri Respiratory Failure (MRF) Questionnaire. We aimed to compare the characteristics of the SRI, MRF-26, and St. George's Respiratory Questionnaire (SGRQ) for use in patients with home noninvasive ventilation (NIV). METHODS: Fifty-six outpatients receiving long-term NIV were recruited and underwent assessments of pulmonary function, arterial blood gas, HRQL, dyspnea, and psychological status...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28588382/county-smoke-free-laws-and-asthma-discharges-evidence-from-17-us-states
#20
Glenn M Landers, Patricia Ketsche, Mark L Diana, Claudia Campbell
BACKGROUND: Although approximately 82 percent of the US population was covered by some form of law that restricted smoking in public establishments as of 2014, most research examining the relationship between smoke-free laws and health has been focused at the state level. PURPOSE: To examine the effect of county workplace smoke-free laws over and above the effect of other (restaurant or bar) smoke-free laws on adult asthma. METHODS: The study estimated the effect of rates of adult asthma discharges before and after the implementation of county nonhospitality workplace smoke-free laws and county restaurant and bar smoke-free laws...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
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