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Canadian Respiratory Journal: Journal of the Canadian Thoracic Society

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https://www.readbyqxmd.com/read/30018677/inhaled-therapy-in-respiratory-disease-the-complex-interplay-of-pulmonary-kinetic-processes
#1
REVIEW
Jens Markus Borghardt, Charlotte Kloft, Ashish Sharma
The inhalation route is frequently used to administer drugs for the management of respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared with other routes of administration, inhalation offers a number of advantages in the treatment of these diseases. For example, via inhalation, a drug is directly delivered to the target organ, conferring high pulmonary drug concentrations and low systemic drug concentrations. Therefore, drug inhalation is typically associated with high pulmonary efficacy and minimal systemic side effects...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/30008977/impact-of-nasopharyngeal-filmarray-respiratory-panel-results-on-antimicrobial-decisions-in-hospitalized-patients
#2
Kenneth K Sakata, Natalya Azadeh, Anjuli Brighton, M'hamed Temkit, Christine L Klassen, Thomas E Grys, Holenarasipur R Vikram
Objective: To determine whether results of the nasopharyngeal FilmArray respiratory panel (NP-FARP) influenced antibiotic decisions. Methods: We reviewed the medical records of nonintensive care unit (ICU) inpatients that had an NP-FARP performed at our institution between June 2013 and June 2014. The inpatient records were reviewed 48 hours after the NP-FARP for the following data: demographic information; NP-FARP, serum procalcitonin, and methicillin-resistant Staphylococcus aureus nasal swab (MRSA NS) results; antibiotics prior and post-48 hours of the NP-FARP result; and the current immunosuppression status...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29973963/inhalation-techniques-used-in-patients-with-respiratory-failure-treated-with-noninvasive-mechanical-ventilation
#3
REVIEW
Patrycja Rzepka-Wrona, Szymon Skoczynski, Dawid Wrona, Adam Barczyk
The administration of aerosolized medication is a basic therapy for patients with numerous respiratory tract diseases, including obstructive airway diseases (OADs), cystic fibrosis (CF), and infectious airway diseases. The management and care for patients requiring mechanical ventilation remains one of the greatest challenges for medical practitioners, both in intensive care units (ICUs) and pulmonology wards. Aerosol therapy is often necessary for patients receiving noninvasive ventilation (NIV), which may be stopped for the time of drug delivery and administered through a metered-dose inhaler or nebulizer in the traditional way...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29973962/the-relation-between-pregnancy-associated-plasma-protein-a-and-obstructive-sleep-apnea-syndrome
#4
Ali Cengiz, Suat Konuk, Tuncer Tuğ
Aim: We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS). Materials and Method: 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with <18 years of age were excluded...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29973961/erratum-to-adrb2-arg16gly-polymorphism-and-pulmonary-function-response-of-inhaled-corticosteroids-plus-long-acting-beta-agonists-for-asthma-treatment-a-systematic-review-and-meta-analysis
#5
Xi Wang, Qian Li, Ruming Liu, Jin He, Di Wu, Yun Wang, Jun Zhang
[This corrects the article DOI: 10.1155/2018/5712805.].
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29951160/matching-inhaler-devices-with-patients-the-role-of-the-primary-care-physician
#6
REVIEW
Alan Kaplan, David Price
Poor inhaler technique and nonadherence impair the efficacy of medications for asthma and chronic obstructive pulmonary disease (COPD). A range of factors, including age, dexterity, inspiratory capacity, cognitive ability, health literacy, and ethnicity, can impact a patient's ability and intention to use their device. Treatment success can also be influenced by patient preferences and perceptions. Therefore, it is important that healthcare professionals effectively match inhaler devices to individual patients' needs and abilities and empower patients by including them in treatment decisions...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29951159/corrigendum-to-fully-covered-metallic-stents-for-the-treatment-of-benign-airway-stenosis
#7
Caroline Dahlqvist, Sebahat Ocak, Maximilien Gourdin, Anne Sophie Dincq, Laurie Putz, Jean-Paul d'Odémont
[This corrects the article DOI: 10.1155/2016/8085216.].
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29887927/pretreatment-hemoglobin-level-is-an-independent-prognostic-factor-in-patients-with-lung-adenocarcinoma
#8
Yue-Hua Zhang, Yuquan Lu, Hong Lu, Meng-Wei Zhang, Yue-Min Zhou, Xiang-Lei Li
Background/Aim: Few studies have reported the prognostic value of pretreatment hemoglobin levels in patients with lung adenocarcinoma (LA). In the present study, we retrospectively reviewed 306 LA patients for their prognosis associated with the pretreatment hemoglobin levels. Methods: Person-years and case fatality rate (CFR) were calculated from May 2010 to June 2017. Hazard ratio (HR) and 95% confidence intervals (CIs) were estimated using the Cox proportional hazards regression analysis...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29854032/ezh2-inhibition-ameliorates-transverse-aortic-constriction-induced-pulmonary-arterial-hypertension-in-mice
#9
Zhan-Li Shi, Kun Fang, Zhi-Hui Li, Dan-Hong Ren, Jia-Ying Zhang, Jing Sun
Background: EPZ005687 is a selective inhibiter of methyltransferase EZH2. In this article, we investigated the protective role and mechanism of EPZ005687 in transverse aortic constriction-induced pulmonary arterial hypertension in mice. Methods: We assigned 15 (6-8 weeks old) male balb/c mice to 3 groups randomly: Sham control + DMSO group, TAC + DMSO group, and TAC + EPZ005687 group (10 mg kg-1 , once a week for 4 weeks). On day 28 following TAC operation, the right ventricular systolic blood pressure (RVSBP) was measured, and lung tissues were collected for laboratory examinations (DHE, Western blot, real-time PCR, and ChIP)...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29854031/model-for-developing-a-health-related-quality-of-life-questionnaire-for-chronic-obstructive-pulmonary-disease
#10
Nikolić Emilija, Nikolić Aleksandar, Stević Ruža, Brandmajer Tijana, Mićanović Veselin, Mašnić Jelena
Introduction: The St. George's Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) Dyspnea Scale, Hospital Anxiety and Depression Scale (HADS), and general health questionnaire (SF-36) are widely used for chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). Aim: We examined the reliability and validity of a modified questionnaire (MQ) to create a model for assessing the health-related quality of life (HRQOL) in COPD...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29854030/budesonide-and-calcitriol-synergistically-inhibit-airway-remodeling-in-asthmatic-mice
#11
Jun Qian, Yaqin Xu, Zhiwei Yu
Background and Objective: While calcitriol can inhibit airway remodeling in asthmatic mice, the mechanism remains unclear. The purpose of this study was to explore the mechanism of action of calcitriol on airway remodeling in asthma and its interaction with budesonide. Methods: A mouse model of asthma was established by allergic sensitization and challenge with ovalbumin. The mice were treated with budesonide, calcitriol, or budesonide plus calcitriol. The expression of airway remodeling-related proteins, transforming growth factor β (TGF β ) signaling pathway-related proteins, the glucocorticoid receptor, and vitamin D receptor (VDR) was determined by immunohistochemical staining and Western blot analysis...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29854029/effect-of-nasal-obstructive-disorders-on-sinonasal-symptoms-in-children-with-different-levels-of-bronchial-asthma-control
#12
T I Eliseeva, S V Krasilnikova, N A Geppe, S Yu Babaev, E V Tush, O V Khaletskaya, D Yu Ovsyannikov, I I Balabolkin, S K Ignatov, N I Kubysheva
Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8.9; 10.7] years old, with atopic BA were assessed using ACQ-5 for the BA control level, TNSS for nasal symptoms, and SNOT-20 for synonasal quality of life in combination with rhinovideoendoscopy for NOD...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29849836/transition-from-ambrisentan-to-bosentan-in-pulmonary-arterial-hypertension-a-single-center-prospective-study
#13
Su-Gang Gong, Lan Wang, Bigyan Pudasaini, Ping Yuan, Rong Jiang, Qin-Hua Zhao, Jing He, Rui Zhang, Wen-Hui Wu, Jin-Ming Liu, Cai-Cun Zhou
Background and objective : Two endothelin receptor antagonists (ETRAs), bosentan and ambrisentan, are approved for patients with pulmonary arterial hypertension (PAH). However, there is little information about the transition strategy between these two ETRAs. We aimed to evaluate the safety and efficacy from ambrisentan to bosentan. Methods : Twenty PAH patients were enrolled into the single-center, open-labelled prospective study. Echocardiogram, WHO functional class (WHO-FC), 6-minute walking distance (6MWD), right heart catheterization, and hemotology were collected...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29849835/elisa-development-for-serum-hemeoxygenase-1-and-its-application-to-patients-with-acute-respiratory-distress-syndrome
#14
Yu Hara, Masaharu Shinkai, Masataka Taguri, Kenjiro Nagai, Satoru Hashimoto, Takeshi Kaneko
Background: Hemeoxygenase-1 (HO-1) is an essential enzyme in heme catabolism and has been proposed as a biomarker of lung disease prognosis. We modified a commercial HO-1 enzyme-linked immunosorbent assay (ELISA) kit to achieve higher sensitivity and evaluated if serum HO-1 could be a biomarker to predict the prognosis of acute respiratory distress syndrome (ARDS) patients. Methods: Serum samples were collected from 15 healthy volunteers to validate the modified ELISA...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29849834/verification-of-a-motion-sensor-for-evaluating-physical-activity-in-copd-patients
#15
Seiko Miyamoto, Yoshiaki Minakata, Yuichiro Azuma, Kazumi Kawabe, Hideya Ono, Ryuta Yanagimoto, Tadatoshi Suruda
Background: Objective evaluation of the physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) is important. We validated a triaxial accelerometer, Active Style Pro HJA-750C® (HJA), and evaluated the necessary conditions for obtaining reproducible data. Methods: The PA measured by HJA was compared with that measured by two already validated accelerometers in 11 patients with COPD (age: 76.6 ± 6.9, FEV1% predicted: 57.6 ± 18...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29849833/positive-pneumocystis-jirovecii-sputum-pcr-results-with-negative-bronchoscopic-pcr-results-in-suspected-pneumocystis-pneumonia
#16
Kelly Pennington, John Wilson, Andrew H Limper, Patricio Escalante
Introduction: The diagnostic standard for Pneumocystis jirovecii pneumonia (PCP) is direct microscopic identification; however, in recent years, polymerase chain reaction (PCR) from bronchoalveolar lavage (BAL) samples to detect Pneumocystis nucleic acids has proven to be more sensitive and specific. Sputum samples have been presumed inferior to bronchoscopic samples secondary to variability and adequacy of sample collection. We observed several cases of positive sputum PCP-PCR results with negative PCP-PCR BAL results...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29849832/chronic-intermittent-hypoxia-induces-the-long-term-facilitation-of-genioglossus-corticomotor-activity
#17
Ying Zou, Wei Wang, Xinshi Nie, Jian Kang
Obstructive sleep apnea (OSA) is characterized by the repetitive collapse of the upper airway and chronic intermittent hypoxia (CIH) during sleep. It has been reported that CIH can increase the EMG activity of genioglossus in rats, which may be related to the neuromuscular compensation of OSA patients. This study aimed to explore whether CIH could induce the long-term facilitation (LTF) of genioglossus corticomotor activity. 16 rats were divided into the air group ( n =8) and the CIH group ( n =8). The CIH group was exposed to hypoxia for 4 weeks; the air group was subjected to air under identical experimental conditions in parallel...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29849831/optimizing-the-delivery-of-inhaled-medication-for-respiratory-patients-the-role-of-valved-holding-chambers
#18
REVIEW
R Andrew McIvor, Hollie M Devlin, Alan Kaplan
Valved holding chambers (VHCs) have been used with pressurized metered-dose inhalers since the early 1980s. They have been shown to increase fine particle delivery to the lungs, decrease oropharyngeal deposition, and reduce side effects such as throat irritation, dysphonia, and oral candidiasis that are common with use of pressurized metered-dose inhalers (pMDIs) alone. VHCs act as aerosol reservoirs, allowing the user to actuate the pMDI device and then inhale the medication in a two-step process that helps users overcome challenges in coordinating pMDI actuation with inhalation...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29849830/comparison-of-respiratory-pathogen-detection-in-upper-versus-lower-respiratory-tract-samples-using-the-biofire-filmarray-respiratory-panel-in-the-immunocompromised-host
#19
Natalya Azadeh, Kenneth K Sakata, Ali Saeed, John J Mullon, Thomas E Grys, Andrew H Limper, Matthew J Binnicker
Background: The FilmArray Respiratory Panel (FARP) (BioFire Diagnostics, Inc.) is a multiplex, polymerase chain reaction (PCR) technique that can detect 17 respiratory viruses and 3 bacterial targets in a single reaction. Immunocompromised hosts (ICH) with respiratory illnesses often undergo bronchoscopy with bronchoalveolar lavage (BAL). This prospective study aimed to evaluate the yield and concordance of NP and BAL FARP testing when performed on the same patient concurrently. Methods: From February to December 2016, 125 patients (100 ICH and 25 non-ICH) were enrolled...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29808103/daily-chronic-intermittent-hypobaric-hypoxia-does-not-induce-chronic-increase-in-pulmonary-arterial-pressure-assessed-by-echocardiography
#20
Jeremias Götschke, Pontus Mertsch, Nikolaus Kneidinger, Diego Kauffmann-Guerrero, Jürgen Behr, Rudolf Maria Huber, Frank Reichenberger, Katrin Milger
Chronic hypoxia causes pulmonary vascular remodeling resulting in persistently increased pulmonary arterial pressures (PAP) even after return to normoxia. Recently, interest in chronic intermittent hypobaric hypoxia (CIHH) was raised because it occurs in subjects working at high altitude (HA) but living in lowland. However, effects of daily CIHH on PAP are unknown. In this pilot study, we included 8 healthy subjects working at (2650 m) each workday for 8-9 h while living and sleeping at LA and 8 matched control subjects living and working at LA...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
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