journal
MENU ▼
Read by QxMD icon Read
search

Matrix Biology: Journal of the International Society for Matrix Biology

journal
https://www.readbyqxmd.com/read/30439444/calcium-activated-nucleotidase-1-cant1-is-critical-for-glycosaminoglycan-biosynthesis-in-cartilage-and-endochondral-ossification
#1
Chiara Paganini, Luca Monti, Rossella Costantini, Roberta Besio, Silvia Lecci, Marco Biggiogera, Kun Tian, Jean-Marc Schwartz, Céline Huber, Valérie Cormier-Daire, Beth G Gibson, Katarzyna A Pirog, Antonella Forlino, Antonio Rossi
Desbuquois dysplasia type 1 (DBQD1) is a chondrodysplasia caused by mutations in CANT1 gene encoding an ER/Golgi calcium activated nucleotidase 1 that hydrolyses UDP. Here, using Cant1 knock-in and knock-out mice recapitulating DBQD1 phenotype, we report that CANT1 plays a crucial role in cartilage proteoglycan synthesis and in endochondral ossification. Specifically, the glycosaminoglycan synthesis was decreased in chondrocytes from Cant1 knock-out mice and their hydrodynamic size was reduced, whilst the sulfation was increased and the overall proteoglycan secretion was delayed...
November 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30412725/rigidity-controls-human-desmoplastic-matrix-anisotropy-to-enable-pancreatic-cancer-cell-spread-via-extracellular-signal-regulated-kinase-2
#2
R Malik, T Luong, X Cao, B Han, N Shah, J Franco-Barraza, L Han, V B Shenoy, P I Lelkes, E Cukierman
It is predicted that pancreatic ductal adenocarcinoma (PDAC) will become the second most lethal cancer in the US by 2030. PDAC includes a fibrous-like stroma, desmoplasia, encompassing most of the tumor mass, which is produced by cancer-associated fibroblasts (CAFs) and includes their cell-derived extracellular matrices (CDMs). Since elimination of desmoplasia has proven detrimental to patients, CDM reprogramming, as opposed to stromal ablation, is therapeutically desirable. Hence, efforts are being made to harness desmoplasia's anti-tumor functions...
November 7, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30394292/effects-of-mutations-in-the-post-translational-modification-sites-on-the-trafficking-of-hyaluronan-synthase-2-has2
#3
R M Melero-Fernandez de Mera, U T Arasu, R Kärnä, S Oikari, K Rilla, D Vigetti, A Passi, P Heldin, M I Tammi, A J Deen
Vesicular trafficking of hyaluronan synthases (HAS1-3) from endoplasmic reticulum (ER) through Golgi to plasma membrane (PM), and either back to endosomes and lysosomes, or out into extracellular vesicles, is important for their activities. We studied how post-translational modifications affect the trafficking of HAS2 by mutagenesis of the sites of ubiquitination (K190R), phosphorylation (T110A) and O-GlcNAcylation (S221A), using Dendra2- and EGFP-HAS2 transfected into COS1 cells. Confocal microscopy showed HAS2 wild type (wt) and its K190R and S221A mutants in ER, Golgi and extracellular vesicles, while the T110A mutant remained mostly in the ER...
October 27, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30408617/integrin-binding-site-within-the-gc1q-domain-orchestrates-emilin-1-induced-lymphangiogenesis
#4
Alessandra Capuano, Eliana Pivetta, Francesca Baldissera, Giulia Bosisio, Bruna Wassermann, Francesco Bucciotti, Alfonso Colombatti, Patrizia Sabatelli, Roberto Doliana, Paola Spessotto
Lymphatic vessels (LVs) play a pivotal role in the control of tissue homeostasis and also have emerged as important regulators of immunity, inflammation and tumor metastasis. EMILIN-1 is the first ECM protein identified as a structural modulator of the growth and maintenance of LV; accordingly, Emilin1-/- mice display lymphatic morphological alterations leading to functional defects as mild lymphedema, leakage and compromised lymph drainage. Many EMILIN-1 functions are exerted by the binding of its gC1q domain with the E933 residue of α4 and α9β1 integrins...
October 26, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30367951/regulation-of-extracellular-matrix-degradation-and-metastatic-spread-by-iqgap1-through-endothelin-1-receptor-signalling-in-ovarian-cancer
#5
Lidia Chellini, Valentina Caprara, Francesca Spadaro, Rosanna Sestito, Anna Bagnato, Laura Rosanò
The invasive phenotype of serous ovarian cancer (SOC) cells is linked to the formation of actin-based protrusions, invadopodia, operating extracellular matrix (ECM) degradation and metastatic spread. Growth factor receptors might cause engagement of integrin-related proteins, like the polarity protein IQ-domain GTPase-activating protein 1 (IQGAP1), to F-actin core needed for invadopodia functions. Here, we investigated whether IQGAP1 forms a signalosome with endothelin-1 (ET-1)/β-arrestin1 (β-arr1) network, as signal-integrating module for adhesion components, cytoskeletal remodelling and ECM degradation...
October 25, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30316981/amino-acid-substitution-in-the-c-terminal-domain-of-collagen-xvii-reduces-laminin-332-interaction-causing-mild-skin-fragility-with-atrophic-scarring
#6
Jasmin Kroeger, Esther Hoppe, Célimène Galiger, Cristina Has, Claus-Werner Franzke
The behavior of a cell depends on how its adhesion molecules interact with the cellular microenvironment. Hemidesmosomal collagen XVII essentially contributes to cell adhesion and modulates keratinocyte directionality and proliferation during skin regeneration, however only little is known about the involved interactions. Here, we used keratinocytes from patients with junctional epidermolysis bullosa with late onset, which exclusively produce a collagen XVII mutant with the p.R1303Q mutation within its extracellular C-terminus...
October 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30273664/dual-role-of-laminin%C3%A2-511-in-regulating-melanocyte-migration-and-differentiation
#7
Yasemin Üstün, Marion Reibetanz, Bent Brachvogel, Roswitha Nischt, Beate Eckes, Paola Zigrino, Thomas Krieg
Laminins are the major basement membrane (BM) components and are heterotrimers composed of an α, a β and a γ chain. In skin, laminins are present in basement membranes surrounding vascular structures, nerves, adipose tissue and in the specialized junctional BM between the epidermis and dermis. The main laminin isoforms in the dermo-epidermal BM are laminin‑332, laminin‑511 and laminin‑211, the latter being restricted to hair follicles (HFs). The laminin γ1 chain is the most abundant γ chain; its global ablation in mice leads to early embryonic lethality at E5...
September 28, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30219651/fibrillin-protein-pleiotropy-acromelic-dysplasias
#8
REVIEW
Lynn Y Sakai, Douglas R Keene
The fibrillins are large extracellular matrix molecules that polymerize to form microfibrils. Fibrillin microfibrils are distinctive architectural elements that are both ubiquitous in the connective tissue space and also unique, displaying tissue-specific patterns. Mutations in the genes for fibrillin-1 (FBN1) result in multiple distinct pleiotropic disorders. Most of the more than 3000 mutations known today in FBN1 cause the Marfan syndrome. Marfan mutations can occur in any of the 56 domains that compose fibrillin-1...
September 13, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30201140/adamts10-inactivation-in-mice-leads-to-persistence-of-ocular-microfibrils-subsequent-to-reduced-fibrillin-2-cleavage
#9
Lauren W Wang, Wendy E Kutz, Timothy J Mead, Lauren C Beene, Shweta Singh, Michael W Jenkins, Dieter P Reinhardt, Suneel S Apte
Mutations in the secreted metalloproteinase ADAMTS10 cause recessive Weill-Marchesani syndrome (WMS), comprising ectopia lentis, short stature, brachydactyly, thick skin and cardiac valve anomalies. Dominant WMS caused by FBN1 mutations is clinically similar and affects fibrillin-1 microfibrils, which are a major component of the ocular zonule. ADAMTS10 was previously shown to enhance fibrillin-1 assembly in vitro. Here, Adamts10 null mice were analyzed to determine the impact of ADAMTS10 deficiency on fibrillin microfibrils in vivo...
September 7, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30196101/hyaluronan-levels-are-increased-systemically-in-human-type-2-but-not-type-1-diabetes-independently-of-glycemic-control
#10
Nadine Nagy, Vivekananda G Sunkari, Gernot Kaber, Sonia Hasbun, Dung N Lam, Cate Speake, Srinath Sanda, Tracey L McLaughlin, Thomas N Wight, Steven R Long, Paul L Bollyky
Hyaluronan (HA), an extracellular matrix glycosaminoglycan, is implicated in the pathogenesis of both type 1 diabetes (T1D) as well as type 2 diabetes (T2D) and has been postulated to be increased in these diseases due to hyperglycemia. We have examined the serum and tissue distribution of HA in human subjects with T1D and T2D and in mouse models of these diseases and evaluated the relationship between HA levels and glycemic control. We found that serum HA levels are increased in T2D but not T1D independently of hemoglobin-A1c, C-peptide, body mass index, or time since diabetes diagnosis...
September 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30194979/has2-natural-antisense-rna-and-hmga2-promote-has2-expression-during-tgf%C3%AE-induced-emt-in-breast-cancer
#11
Constantinos Kolliopoulos, Chun-Yu Lin, Carl-Henrik Heldin, Aristidis Moustakas, Paraskevi Heldin
The glycosaminoglycan hyaluronan has a crucial role in tissue organization and cell signaling. Hyaluronan accumulates in conjunction with rapid tissue remodeling during embryogenesis, as well as in inflammatory conditions and cancer. We report a negative correlation between the expression of genes encoding hyaluronan synthase HAS2, its natural antisense transcript HAS2-AS, the chromatin modulating factor HMGA2 and transforming growth factor-β (TGFβ), and survival of patients with invasive breast carcinomas...
September 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30193893/mir-324-5p-is-up-regulated-in-end-stage-osteoarthritis-and-regulates-indian-hedgehog-signalling-by-differing-mechanisms-in-human-and-mouse
#12
Steven Woods, Matt J Barter, Hannah R Elliott, Catherine M McGillivray, Mark A Birch, Ian M Clark, David A Young
The Hedgehog (Hh) signalling pathway plays important roles during embryonic development and in adult tissue homeostasis, for example cartilage, where its deregulation can lead to osteoarthritis (OA). microRNAs (miRNAs) are important regulators of gene expression, and have been implicated in the regulation of signalling pathways, including Hh, thereby impacting upon development and disease. Our aim was to identify the function of miRNAs whose expression is altered in OA cartilage. Here we identified an increase in miR-324-5p expression in OA cartilage and hypothesised that, as in glioma, miR-324-5p would regulate Hh signalling...
September 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30193894/the-laminin-binding-%C3%AE-3-and-%C3%AE-6-integrins-cooperate-to-promote-epithelial-cell-adhesion-and-growth
#13
Eugenia M Yazlovitskaya, Olga M Viquez, Tianxiang Tu, Adele De Arcangelis, Elisabeth Georges-Labouesse, Arnoud Sonnenberg, Ambra Pozzi, Roy Zent
Integrins, the major receptors for cell-extracellular matrix (ECM) interactions, regulate multiple cell biological processes including adhesion, migration, proliferation and growth factor-dependent signaling. The principal laminin (LM) binding integrins α3β1, α6β1 and α6β4 are usually co-expressed in cells and bind to multiple laminins with different affinities making it difficult to define their specific function. In this study, we generated kidney epithelial collecting duct (CD) cells that lack both the α3 and α6 integrin subunits...
September 4, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29649546/pulmonary-immunity-and-extracellular-matrix-interactions
#14
REVIEW
David N O'Dwyer, Stephen J Gurczynski, Bethany B Moore
The lung harbors a complex immune system composed of both innate and adaptive immune cells. Recognition of infection and injury by receptors on lung innate immune cells is crucial for generation of antigen-specific responses by adaptive immune cells. The extracellular matrix of the lung, comprising the interstitium and basement membrane, plays a key role in the regulation of these immune systems. The matrix consists of several hundred assembled proteins that interact to form a bioactive scaffold. This template, modified by enzymes, acts to facilitate cell function and differentiation and changes dynamically with age and lung disease...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29559389/matrix-remodeling-in-chronic-lung-diseases
#15
REVIEW
Bon-Hee Gu, Matthew C Madison, David Corry, Farrah Kheradmand
Multicellular organisms synthesize and renew components of their subcellular and scaffolding proteins, collectively known as the extracellular matrix molecules (ECMs). In the lung, ECMs maintain tensile strength, elasticity, and dictate the specialized function of multiple cell lineages. These functions are critical in lung homeostatic processes including cellular migration and proliferation during morphogenesis or in response to repair. Alterations in lung ECMs that expose cells to new cryptic fragments, generated in response to endogenous proteinases or exogenous toxins, are associated with the development of several common respiratory diseases...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29524630/extracellular-matrix-in-lung-development-homeostasis-and-disease
#16
REVIEW
Yong Zhou, Jeffrey C Horowitz, Alexandra Naba, Namasivayam Ambalavanan, Kamran Atabai, Jenna Balestrini, Peter B Bitterman, Richard A Corley, Bi-Sen Ding, Adam J Engler, Kirk C Hansen, James S Hagood, Farrah Kheradmand, Qing S Lin, Enid Neptune, Laura Niklason, Luis A Ortiz, William C Parks, Daniel J Tschumperlin, Eric S White, Harold A Chapman, Victor J Thannickal
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29331337/elastin-in-lung-development-and-disease-pathogenesis
#17
REVIEW
Robert P Mecham
Elastin is expressed in most tissues that require elastic recoil. The protein first appeared coincident with the closed circulatory system, and was critical for the evolutionary success of the vertebrate lineage. Elastin is expressed by multiple cell types in the lung, including mesothelial cells in the pleura, smooth muscle cells in airways and blood vessels, endothelial cells, and interstitial fibroblasts. This highly crosslinked protein associates with fibrillin-containing microfibrils to form the elastic fiber, which is the physiological structure that functions in the extracellular matrix...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29274939/matrix-biomechanics-and-dynamics-in-pulmonary-fibrosis
#18
REVIEW
Andrew J Haak, Qi Tan, Daniel J Tschumperlin
The composition and mechanical properties of the extracellular matrix are dramatically altered during the development and progression of pulmonary fibrosis. Recent evidence indicates that these changes in matrix composition and mechanics are not only end-results of fibrotic remodeling, but active participants in driving disease progression. These insights have stimulated interest in identifying the components and physical aspects of the matrix that contribute to cell activation and disease initiation and progression...
November 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29933045/extracellular-matrix-driven-congenital-muscular-dystrophies
#19
REVIEW
Payam Mohassel, A Reghan Foley, Carsten G Bönnemann
Skeletal muscle function relies on the myofibrillar apparatus inside myofibers as well as an intact extracellular matrix surrounding each myofiber. Muscle extracellular matrix (ECM) plays several roles including but not limited to force transmission, regulation of growth factors and inflammatory responses, and influencing muscle stem cell (i.e. satellite cell) proliferation and differentiation. In most myopathies, muscle ECM undergoes remodeling and fibrotic changes that may be maladaptive for normal muscle function and recovery...
October 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29885460/adamts-proteins-in-human-disorders
#20
REVIEW
Timothy J Mead, Suneel S Apte
ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose substrates are extracellular matrix (ECM) components, whereas ADAMTS-like proteins lack a metalloprotease domain, reside in the ECM and have regulatory roles vis-à-vis ECM assembly and/or ADAMTS activity. Evolutionary conservation and expansion of ADAMTS proteins in mammals is suggestive of crucial embryologic or physiological roles in humans...
October 2018: Matrix Biology: Journal of the International Society for Matrix Biology
journal
journal
31961
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"