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Matrix Biology: Journal of the International Society for Matrix Biology

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https://www.readbyqxmd.com/read/30004014/introduction-to-the-thematic-mini-review-series-on-matrix-biology-in-lung-health-and-disease
#1
EDITORIAL
Pyong Woo Park
No abstract text is available yet for this article.
July 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29981373/exosomes-and-exosomal-mirnas-from-muscle-derived-fibroblasts-promote-skeletal-muscle-fibrosis
#2
Simona Zanotti, Sara Gibertini, Flavia Blasevich, Cinzia Bragato, Alessandra Ruggieri, Simona Saredi, Marco Fabbri, Pia Bernasconi, Lorenzo Maggi, Renato Mantegazza, Marina Mora
Exosomes, natural carriers of mRNAs, non-coding RNAs and proteins between donor and recipient cells, actively contribute to cell-cell communication. We investigated the potential pro-fibrotic role of exosomes released by muscle-derived fibroblasts of Duchenne muscular dystrophy (DMD) patients, and of miRNAs carried by exosomes. By fibrosis focused array analysis we found that exosomes from DMD fibroblasts, had significantly higher levels of miR-199a-5p, a miRNA up-regulated in fibrotic conditions, compared to control exosomes, while levels in myoblast-derived exosomes were not increased...
July 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29981372/a-scar-like-lesion-is-apparent-in-basement-membrane-after-wound-repair-in-vivo
#3
William Ramos-Lewis, Kimberly S LaFever, Andrea Page-McCaw
Basement membrane is a highly conserved sheet-like extracellular matrix in animals, underlying simple and complex epithelia, and wrapping around tissues like muscles and nerves. Like the tissues they support, basement membranes become damaged by environmental insults. Although it is clear that basement membranes are repaired after damage, virtually nothing is known about this process. For example, it is not known how repaired basement membranes compare to undamaged ones, whether basement membrane components are necessary for epithelial wound closure, or whether there is a hierarchy of assembly that repairing basement membranes follow, similar to the hierarchy of assembly of embryonic basement membranes...
July 4, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29933044/defective-lung-function-following-influenza-virus-is-due-to-prolonged-reversible-hyaluronan-synthesis
#4
Thomas J Bell, Oliver J Brand, David J Morgan, Samira Salek-Ardakani, Christopher Jagger, Toshifumi Fujimori, Lauren Cholewa, Viranga Tilakaratna, Jörgen Östling, Matt Thomas, Anthony J Day, Robert J Snelgrove, Tracy Hussell
Little is known about the impact of viral infections on lung matrix despite its important contribution to mechanical stability and structural support. The composition of matrix also indirectly controls inflammation by influencing cell adhesion, migration, survival, proliferation and differentiation. Hyaluronan is a significant component of the lung extracellular matrix and production and degradation must be carefully balanced. We have discovered an imbalance in hyaluronan production following resolution of a severe lung influenza virus infection, driven by hyaluronan synthase 2 from epithelial cells, endothelial cells and fibroblasts...
June 20, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29933045/extracellular-matrix-driven-congenital-muscular-dystrophies
#5
REVIEW
Payam Mohassel, A Reghan Foley, Carsten G Bönnemann
Skeletal muscle function relies on the myofibrillar apparatus inside myofibers as well as an intact extracellular matrix surrounding each myofiber. Muscle extracellular matrix (ECM) plays several roles including but not limited to force transmission, regulation of growth factors and inflammatory responses, and influencing muscle stem cell (i.e. satellite cell) proliferation and differentiation. In most myopathies, muscle ECM undergoes remodeling and fibrotic changes that may be maladaptive for normal muscle function and recovery...
June 19, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29894820/cd44-dependent-inflammation-fibrogenesis-and-collagenolysis-regulates-extracellular-matrix-remodeling-and-tensile-strength-during-cutaneous-wound-healing
#6
REVIEW
Priya Govindaraju, Leslie Todd, Snehal Shetye, James Monslow, Ellen Puré
Cutaneous wound healing consists of three main phases: inflammation, re-epithelialization, and tissue remodeling. During normal wound healing, these processes are tightly regulated to allow restoration of skin function and biomechanics. In many instances, healing leads to an excess accumulation of fibrillar collagen (the principal protein found in the extracellular matrix - ECM), and the formation of scar tissue, which has compromised biomechanics, tested using ramp to failure tests, compared to normal skin (Corr and Hart, 2013 [1])...
June 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29885461/activation-of-cancer-associated-fibroblasts-is-required-for-tumor-neovascularization-in-a-murine-model-of-melanoma
#7
James Hutchenreuther, Krista Vincent, Chris Norley, Michael Racanelli, Stephen B Gruber, Timothy M Johnson, Douglas R Fullen, Leon Raskin, Bernard Perbal, David W Holdsworth, Lynne-Marie Postovit, Andrew Leask
Metastatic melanoma is highly fatal. Within the tumor microenvironment, the role of cancer-associated fibroblasts (CAFs) in melanoma metastasis and progression is relatively understudied. The matricellular protein CCN2 (formerly termed connective tissue growth factor, CTGF) is overexpressed, in a fashion independent of BRAF mutational status, by CAFs in melanoma. Herein, we find, in human melanoma patients, that CCN2 expression negatively correlates with survival and positively correlates with expression of neovascularization markers...
June 7, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29885460/adamts-proteins-in-human-disorders
#8
REVIEW
Timothy J Mead, Suneel S Apte
ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose substrates are extracellular matrix (ECM) components, whereas ADAMTS-like proteins lack a metalloprotease domain, reside in the ECM and have regulatory roles vis-à-vis ECM assembly and/or ADAMTS activity. Evolutionary conservation and expansion of ADAMTS proteins in mammals is suggestive of crucial embryologic or physiological roles in humans...
June 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29870768/defective-collagen-proteostasis-and-matrix-formation-in-the-pathogenesis-of-lysosomal-storage-disorders
#9
REVIEW
Carmine Settembre, Laura Cinque, Rosa Bartolomeo, Chiara Di Malta, Chiara De Leonibus, Alison Forrester
The lysosome is a catabolic organelle devoted to the degradation of cellular components, such as protein complexes and whole or portion of organelles that reach the lysosomes through (macro)autophagy. The lysosomes also function as signaling organelles by controlling the activity of key metabolic kinases, such as the mechanistic target of Rapamycin complex 1 (mTORC1). Lysosome dysfunction has dramatic consequences on cellular homeostasis and causes lysosomal storage disorders (LSDs). Here we review the recently proposed mechanisms by which impairment of lysosome/autophagy pathway affects extracellular matrix formation and skeletal development and growth...
June 2, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29842969/serglycin-promotes-breast-cancer-cell-aggressiveness-induction-of-epithelial-to-mesenchymal-transition-proteolytic-activity-and-il-8-signaling
#10
Panagiotis Bouris, Dimitra Manou, Anastasia Sopaki-Valalaki, Anthi Kolokotroni, Aristidis Moustakas, Aastha Kapoor, Renato V Iozzo, Nikos K Karamanos, Achilleas D Theocharis
Serglycin is an intracellular proteoglycan that is expressed and constitutively secreted by numerous malignant cells, especially prominent in the highly-invasive, triple-negative MDA-MB-231 breast carcinoma cells. Notably, de novo expression of serglycin in low aggressive estrogen receptor α (ERα)-positive MCF7 breast cancer cells promotes an aggressive phenotype. In this study, we discovered that serglycin promoted epithelial to mesenchymal transition (EMT) in MCF7 cells as shown by increased expression of mesenchymal markers vimentin, fibronectin and EMT-related transcription factor Snail2...
May 26, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29803939/the-heparan-sulfate-proteoglycan-grip-on-hyperlipidemia-and-atherosclerosis
#11
REVIEW
Philip L S M Gordts, Jeffrey D Esko
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in lipid homeostasis and inflammation. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions in the context of cardiovascular disease. The majority of cardiovascular disease-related deaths are caused by complications of atherosclerosis, a disease that results in narrowing of the arterial lumen, thereby reducing blood flow to critical levels in vital organs, such as the heart and brain...
May 24, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29803938/cartilage-diseases
#12
REVIEW
Yamini Krishnan, Alan J Grodzinsky
Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth. The structure and organization of cartilage's extracellular matrix (ECM) are the primary determinants of normal function. Most diseases involving cartilage lead to dramatic changes in the ECM which can govern disease progression (e...
May 24, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29803937/tissue-linkage-through-adjoining-basement-membranes-the-long-and-the-short-term-of-it
#13
REVIEW
Daniel P Keeley, David R Sherwood
Basement membranes (BMs) are thin dense sheets of extracellular matrix that surround most tissues. When the BMs of neighboring tissues come into contact, they usually slide along one another and act to separate tissues and organs into distinct compartments. However, in certain specialized regions, the BMs of neighboring tissues link, helping to bring tissues together. These BM connections can be transient, such as during tissue fusion events in development, or long-term, as with adult tissues involved with filtration, including the blood brain barrier and kidney glomerulus...
May 24, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29800616/osteoarthritis-as-a-disease-of-the-cartilage-pericellular-matrix
#14
REVIEW
Farshid Guilak, Robert J Nims, Amanda Dicks, Chia-Lung Wu, Ingrid Meulenbelt
Osteoarthritis is a painful joint disease characterized by progressive degeneration of the articular cartilage as well as associated changes to the subchondral bone, synovium, and surrounding joint tissues. While the effects of osteoarthritis on the cartilage extracellular matrix (ECM) have been well recognized, it is now becoming apparent that in many cases, the onset of the disease may be initially reflected in the matrix region immediately surrounding the chondrocytes, termed the pericellular matrix (PCM)...
May 22, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29792915/the-cd44-ha-axis-and-inflammation-in-atherosclerosis-a-temporal-perspective
#15
REVIEW
Mia Krolikoski, James Monslow, Ellen Puré
Cardiovascular disease (CVD) due to atherosclerosis is a disease of chronic inflammation at both the systemic and the tissue level. CD44 has previously been implicated in atherosclerosis in both humans and mice. This multi-faceted receptor plays a critical part in the inflammatory response during the onset of CVD, though little is known of CD44's role during the latter stages of the disease. This review focuses on the role of CD44-dependent HA-dependent effects on inflammatory cells in several key processes, from disease initiation throughout the progression of atherosclerosis...
May 21, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29777767/biglycan-is-a-new-high-affinity-ligand-for-cd14-in-macrophages
#16
Heiko Roedig, Madalina V Nastase, Helena Frey, Kristin Moreth, Jinyang Zeng-Brouwers, Chiara Poluzzi, Louise Tzung-Harn Hsieh, Christian Brandts, Simone Fulda, Malgorzata Wygrecka, Liliana Schaefer
Sterile inflammation is a therapeutic target in many diseases where it represents an important initiator of disease progression. However, the detailed mechanisms underlying its evolution and biological relevance are not yet completely elucidated. Biglycan, a prototype extracellular matrix-derived damage-associated molecular pattern, mediates sterile inflammation in macrophages through Toll-like receptor (TLR) 2 and/or TLR4-dependent signaling pathways. Here we discovered that soluble biglycan is a novel high-affinity ligand for CD14, a well-known GPI-anchored co-receptor for TLRs...
May 17, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29758265/interactions-between-lysyl-oxidases-and-adamts-proteins-suggest-a-novel-crosstalk-between-two-extracellular-matrix-families
#17
Rohtem Aviram, Shelly Zaffryar-Eilot, Dirk Hubmacher, Hagar Grunwald, Joni M Mäki, Johanna Myllyharju, Suneel S Apte, Peleg Hasson
The extracellular matrix (ECM) regulates numerous cellular events in addition to providing structural integrity. Among several protein and enzyme families implicated in functions of the ECM, the lysyl oxidases and ADAMTS proteins are known to participate in microfibril and elastic fiber formation as well as ECM-associated signaling. A yeast two-hybrid screen to identify lysyl oxidase (LOX) binding proteins identified ADAMTSL4 as a potential interactor. We demonstrate here that several members of the LOX and ADAMTS families interact with one another...
May 17, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29763670/goodpasture-s-autoimmune-disease-a-collagen-iv-disorder
#18
REVIEW
Vadim Pedchenko, A Richard Kitching, Billy G Hudson
Goodpasture's (GP) disease is an autoimmune disorder characterized by the deposition of pathogenic autoantibodies in basement membranes of kidney and lung eliciting rapidly progressive glomerulonephritis and pulmonary hemorrhage. The principal autoantigen is the α345 network of collagen IV, which expression is restricted to target tissues. Recent discoveries include a key role of chloride and bromide for network assembly, a novel posttranslational modification of the antigen, a sulfilimine bond that crosslinks the antigen, and the mechanistic role of HLA in genetic susceptibility and resistance to GP disease...
May 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29753676/prostate-tumor-cell-exosomes-containing-hyaluronidase-hyal1-stimulate-prostate-stromal-cell-motility-by-engagement-of-fak-mediated-integrin-signaling
#19
Caitlin O McAtee, Christine Booth, Christian Elowsky, Lei Zhao, Jeremy Payne, Teresa Fangman, Steve Caplan, Michael D Henry, Melanie A Simpson
The hyaluronidase Hyal1 is clinically and functionally implicated in prostate cancer progression and metastasis. Elevated Hyal1 accelerates vesicular trafficking in prostate tumor cells, thereby enhancing their metastatic potential in an autocrine manner through increased motility and proliferation. In this report, we found Hyal1 protein is a component of exosomes produced by prostate tumor cell lines overexpressing Hyal1. We investigated the role of exosomally shed Hyal1 in modulating tumor cell autonomous functions and in modifying the behavior of prostate stromal cells...
May 10, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29738833/emerging-concepts-in-the-epidemiology-pathophysiology-and-clinical-care-of-osteoporosis-across-the-menopausal-transition
#20
REVIEW
Daria Lizneva, Tony Yuen, Li Sun, Se-Min Kim, Ihor Atabiekov, Lubna Bashir Munshi, Sol Epstein, Maria New, Mone Zaidi
Bone loss in women accelerates during perimenopause, and continues into old age. To-date, there has been little progress made in stratifying for fracture risk in premenopausal and early postmenopausal women. Epidemiologic data suggests that changes in serum FSH could predict decrements in bone mass during peri- and postmenopause. In bone, FSH stimulates osteoclast formation by releasing osteoclastogenic cytokines. Here, we address the evidence for bone loss across the menopausal transition, discuss strategies for detection and treatment of early postmenopausal osteoporosis, and describe the role FSH plays in physiology and likely in pathophysiology of early postmenopausal bone loss...
May 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
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