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Matrix Biology: Journal of the International Society for Matrix Biology

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https://www.readbyqxmd.com/read/30219651/fibrillin-protein-pleiotropy-acromelic-dysplasias
#1
REVIEW
Lynn Y Sakai, Douglas R Keene
The fibrillins are large extracellular matrix molecules that polymerize to form microfibrils. Fibrillin microfibrils are distinctive architectural elements that are both ubiquitous in the connective tissue space and also unique, displaying tissue-specific patterns. Mutations in the genes for fibrillin-1 (FBN1) result in multiple distinct pleiotropic disorders. Most of the more than 3000 mutations known today in FBN1 cause the Marfan syndrome. Marfan mutations can occur in any of the 56 domains that compose fibrillin-1...
September 13, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30201140/adamts10-inactivation-in-mice-leads-to-persistence-of-ocular-microfibrils-subsequent-to-reduced-fibrillin-2-cleavage
#2
Lauren W Wang, Wendy E Kutz, Timothy J Mead, Lauren C Beene, Shweta Singh, Michael W Jenkins, Dieter P Reinhardt, Suneel S Apte
Mutations in the secreted metalloproteinase ADAMTS10 cause recessive Weill-Marchesani syndrome (WMS), comprising ectopia lentis, short stature, brachydactyly, thick skin and cardiac valve stenosis. Dominant WMS caused by FBN1 mutations is clinically similar and affects fibrillin-1 microfibrils, which are a major component of the ocular zonule. ADAMTS10 was previously shown to enhance fibrillin-1 assembly in vitro. Here, Adamts10 null mice were analyzed to determine the impact of ADAMTS10 deficiency on fibrillin microfibrils in vivo...
September 7, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30196101/hyaluronan-levels-are-increased-systemically-in-human-type-2-but-not-type-1-diabetes-independently-of-glycemic-control
#3
Nadine Nagy, Vivekananda G Sunkari, Gernot Kaber, Sonia Hasbun, Dung N Lam, Cate Speake, Srinath Sanda, Tracey L McLaughlin, Thomas N Wight, Steven R Long, Paul L Bollyky
Hyaluronan (HA), an extracellular matrix glycosaminoglycan, is implicated in the pathogenesis of both type 1 diabetes (T1D) as well as type 2 diabetes (T2D) and has been postulated to be increased in these diseases due to hyperglycemia. We have examined the serum and tissue distribution of HA in human subjects with T1D and T2D and in mouse models of these diseases and evaluated the relationship between HA levels and glycemic control. We found that serum HA levels are increased in T2D but not T1D independently of hemoglobin-A1c, C-peptide, body mass index, or time since diabetes diagnosis...
September 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30194979/has2-natural-antisense-rna-and-hmga2-promote-has2-expression-during-tgf%C3%AE-induced-emt-in-breast-cancer
#4
Constantinos Kolliopoulos, Chun-Yu Lin, Carl-Henrik Heldin, Aristidis Moustakas, Paraskevi Heldin
The glycosaminoglycan hyaluronan has a crucial role in tissue organization and cell signaling. Hyaluronan accumulates in conjunction with rapid tissue remodeling during embryogenesis, as well as in inflammatory conditions and cancer. We report a negative correlation between the expression of genes encoding hyaluronan synthase HAS2, its natural antisense transcript HAS2-AS, the chromatin modulating factor HMGA2 and transforming growth factor-β (TGFβ), and survival of patients with invasive breast carcinomas...
September 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30193893/mir-324-5p-is-up-regulated-in-end-stage-osteoarthritis-and-regulates-indian-hedgehog-signalling-by-differing-mechanisms-in-human-and-mouse
#5
Steven Woods, Matt J Barter, Hannah R Elliott, Catherine M McGillivray, Mark A Birch, Ian M Clark, David A Young
The Hedgehog (Hh) signalling pathway plays important roles during embryonic development and in adult tissue homeostasis, for example cartilage, where its deregulation can lead to osteoarthritis (OA). microRNAs (miRNAs) are important regulators of gene expression, and have been implicated in the regulation of signalling pathways, including Hh, thereby impacting upon development and disease. Our aim was to identify the function of miRNAs whose expression is altered in OA cartilage. Here we identified an increase in miR-324-5p expression in OA cartilage and hypothesised that, as in glioma, miR-324-5p would regulate Hh signalling...
September 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30193894/the-laminin-binding-%C3%AE-3-and-%C3%AE-6-integrins-cooperate-to-promote-epithelial-cell-adhesion-and-growth
#6
Eugenia M Yazlovitskaya, Olga M Viquez, Tianxiang Tu, Adele De Arcangelis, Elisabeth Georges-Labouesse, Arnoud Sonnenberg, Ambra Pozzi, Roy Zent
Integrins, the major receptors for cell-extracellular matrix (ECM) interactions, regulate multiple cell biological processes including adhesion, migration, proliferation and growth factor-dependent signaling. The principal laminin (LM) binding integrins α3β1, α6β1 and α6β4 are usually co-expressed in cells and bind to multiple laminins with different affinities making it difficult to define their specific function. In this study, we generated kidney epithelial collecting duct (CD) cells that lack both the α3 and α6 integrin subunits...
September 4, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30130585/hyaluronic-acid-cd44-and-rhamm-regulate-myoblast-behavior-during-embryogenesis
#7
Yue Leng, Ammara Abdullah, Michael K Wendt, Sarah Calve
Hyaluronic acid (HA) is an extracellular matrix (ECM) component that has been shown to play a significant role in regulating muscle cell behavior during repair and regeneration. For instance, ECM remodeling after muscle injury involves an upregulation in HA expression that is coupled with skeletal muscle precursor cell recruitment. However, little is known about the role of HA during skeletal muscle development. To gain insight into the way in which HA mediates embryonic myogenesis, we first determined the spatial distribution and gene expression of CD44, RHAMM and other HA related proteins in embryonic day (E)10...
August 18, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30130584/matrix-modeling-and-remodeling-a-biological-interplay-regulating-tissue-homeostasis-and-diseases
#8
REVIEW
Nikos K Karamanos, Achilleas D Theocharis, Thomas Neill, Renato V Iozzo
The overall structure and architecture of the extracellular matrix undergo dramatic alterations in composition, form, and functionality over time. The stochasticity begins during development, essential for maintaining organismal homeostasis and is heavily implicated in many pathobiological states including fibrosis and cancer. Modeling and remodeling of the matrix is driven by the local cellular milieu and secreted and cell-associated components in a framework of dynamic reciprocity. This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease...
August 18, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30125619/internal-cleavage-and-synergy-with-twisted-gastrulation-enhance-bmp-inhibition-by-bmper
#9
Michael P Lockhart-Cairns, Karen Tzia Wei Lim, Alexandra Zuk, Alan R F Godwin, Stuart A Cain, Gerhard Sengle, Clair Baldock
Bone morphogenetic proteins (BMPs) are essential signalling molecules involved in developmental and pathological processes and are regulated in the matrix by secreted glycoproteins. One such regulator is BMP-binding endothelial cell precursor-derived regulator (BMPER) which can both inhibit and enhance BMP signalling in a context and concentration-dependent manner. Twisted gastrulation (Tsg) can also promote or ablate BMP activity but it is unclear whether Tsg and BMPER directly interact and thereby exert a synergistic function on BMP signalling...
August 18, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30098420/the-receptor-for-hyaluronan-mediated-motility-cd168-promotes-inflammation-and-fibrosis-after-acute-lung-injury
#10
Zheng Cui, Jie Liao, Naeun Cheong, Christopher Longoria, Gaoyuan Cao, Horace M DeLisser, Rashmin C Savani
Acute lung injury results in early inflammation and respiratory distress, and later fibrosis. The glycosaminoglycan hyaluronan (HA) and the Receptor for Hyaluronan-Mediated Motility (RHAMM, CD168) have been implicated in the response to acute lung injury. We hypothesized that, compared to wild type (WT) mice, RHAMM knockout (KO) mice would be protected from, whereas mice with macrophage-specific transgenic overexpression of RHAMM (TG) would have worse inflammation, respiratory distress and fibrosis after intratracheal (IT) bleomycin...
August 8, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30098419/prostate-cancer-sheds-the-%C3%AE-v%C3%AE-3-integrin-in-vivo-through-exosomes
#11
Shiv Ram Krishn, Amrita Singh, Nicholas Bowler, Alexander N Duffy, Andrea Friedman, Carmine Fedele, Senem Kurtoglu, Sushil K Tripathi, Kerith Wang, Adam Hawkins, Aejaz Sayeed, Chirayu P Goswami, Madhukar L Thakur, Renato V Iozzo, Stephen C Peiper, William K Kelly, Lucia R Languino
The αvβ3 integrin has been shown to promote aggressive phenotypes in many types of cancers, including prostate cancer. We show that GFP-labeled αvβ3 derived from cancer cells circulates in the blood and is detected in distant lesions in NOD scid gamma (NSG) mice. We, therefore, hypothesized that αvβ3 travels through exosomes and tested its levels in pools of vesicles, which we designate extracellular vesicles highly enriched in exosomes (ExVs), and in exosomes isolated from the plasma of prostate cancer patients...
August 8, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30096360/the-heparanase-inhibitor-pg545-is-a-potent-anti-lymphoma-drug-mode-of-action
#12
Marina Weissmann, Udayan Bhattacharya, Sari Feld, Edward Hammond, Neta Ilan, Israel Vlodavsky
It is now well recognized that heparanase, an endo-β-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, promotes tumorigenesis by diverse mechanisms. Compelling evidence strongly implies that heparanase is a viable target for cancer therapy, thus encouraging the development of heparanase inhibitors as anti-cancer therapeutics. Here, we examined the efficacy and mode of action of PG545, an HS-mimetic heparanase inhibitor, in human lymphoma. We found that PG545 exhibits a strong anti-lymphoma effect, eliciting lymphoma cell apoptosis...
August 7, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30092283/topological-remodeling-of-cortical-perineuronal-nets-in-focal-cerebral-ischemia-and-mild-hypoperfusion
#13
Egor Dzyubenko, Daniel Manrique-Castano, Christoph Kleinschnitz, Andreas Faissner, Dirk M Hermann
Despite the crucial role of perineuronal nets (PNNs) in neural plasticity and neurological disorders, their ultrastructural organization remains largely unresolved. We have developed a novel approach combining superresolution structured illumination microscopy (SR-SIM) and mathematical reconstruction that allows for quantitative analysis of PNN topology. Since perineuronal matrix is capable to restrict neural plasticity but at the same time is necessary to maintain synapses, we hypothesized that a beneficial post stroke recovery requires a reversible loosening of PNNs...
August 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30092282/rna-binding-protein-hur-regulates-extracellular-matrix-gene-expression-and-ph-homeostasis-independent-of-controlling-hif-1%C3%AE-signaling-in-nucleus-pulposus-cells
#14
Hehai Pan, Adam Strickland, Vedavathi Madhu, Zariel I Johnson, Saswati N Chand, Jonathan R Brody, Andrzej Fertala, Zhaomin Zheng, Irving M Shapiro, Makarand V Risbud
Nucleus pulposus (NP) cells reside in the hypoxic niche of the intervertebral disc. Studies have demonstrated that RNA-binding protein HuR modulates hypoxic signaling in several cancers, however, its function in the disc is unknown. HuR did not show cytoplasmic translocation in hypoxia and evidenced levels of Hif-1α and HIF-targets in NP cells. RNA-Sequencing data revealed important extracellular matrix-related genes including several collagens, MMPs, aggrecan, Tgf-β3 and Sdc4 were regulated by HuR. Analysis of HuR-silenced NP cells confirmed that HuR maintained expression of these matrix genes...
August 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30077625/hyaluronan-cd44-interaction-promotes-hpv-16-e6-oncogene-mediated-oropharyngeal-cell-carcinoma-survival-and-chemoresistance
#15
Lilly Y W Bourguignon, Christine Earle, Marisa Shiina
Head and neck squamous cell carcinoma (HNSCC) is a malignancy that often involves the oral cavity, pharynx, larynx, or paranasal sinuses. There is a compelling evidence of the human papilloma virus including HPV16 E6 oncogene drives cell transformation and oncogenic processes of HPV positive (HVP+) HNSCC [in particular, Oropharyngeal Squamous Cell Carcinoma (OPSCC)]. In this study, we determined that human OPSCC-derived, HPV16 E6+ cells (UMSCC-104 and UMSCC-47 cell lines) express CD44 and a regulatory transcription factor, c-Jun...
August 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30031067/gene-profile-of-zebrafish-fin-regeneration-offers-clues-to-kinetics-organization-and-biomechanics-of-basement-membrane
#16
Pauline Nauroy, Alexandre Guiraud, Julien Chlasta, Marilyne Malbouyres, Benjamin Gillet, Sandrine Hughes, Elise Lambert, Florence Ruggiero
How some animals regenerate missing body parts is not well understood. Taking advantage of the zebrafish caudal fin model, we performed a global unbiased time-course transcriptomic analysis of fin regeneration. Biostatistics analyses identified extracellular matrix (ECM) as the most enriched gene sets. Basement membranes (BMs) are specialized ECM structures that provide tissues with structural cohesion and serve as a major extracellular signaling platform. While the embryonic formation of BM has been extensively investigated, its regeneration in adults remains poorly studied...
July 19, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/30004014/introduction-to-the-thematic-mini-review-series-on-matrix-biology-in-lung-health-and-disease
#17
EDITORIAL
Pyong Woo Park
No abstract text is available yet for this article.
July 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29981373/exosomes-and-exosomal-mirnas-from-muscle-derived-fibroblasts-promote-skeletal-muscle-fibrosis
#18
Simona Zanotti, Sara Gibertini, Flavia Blasevich, Cinzia Bragato, Alessandra Ruggieri, Simona Saredi, Marco Fabbri, Pia Bernasconi, Lorenzo Maggi, Renato Mantegazza, Marina Mora
Exosomes, natural carriers of mRNAs, non-coding RNAs and proteins between donor and recipient cells, actively contribute to cell-cell communication. We investigated the potential pro-fibrotic role of exosomes released by muscle-derived fibroblasts of Duchenne muscular dystrophy (DMD) patients, and of miRNAs carried by exosomes. By fibrosis focused array analysis we found that exosomes from DMD fibroblasts, had significantly higher levels of miR-199a-5p, a miRNA up-regulated in fibrotic conditions, compared to control exosomes, while levels in myoblast-derived exosomes were not increased...
July 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29981372/a-scar-like-lesion-is-apparent-in-basement-membrane-after-wound-repair-in-vivo
#19
William Ramos-Lewis, Kimberly S LaFever, Andrea Page-McCaw
Basement membrane is a highly conserved sheet-like extracellular matrix in animals, underlying simple and complex epithelia, and wrapping around tissues like muscles and nerves. Like the tissues they support, basement membranes become damaged by environmental insults. Although it is clear that basement membranes are repaired after damage, virtually nothing is known about this process. For example, it is not known how repaired basement membranes compare to undamaged ones, whether basement membrane components are necessary for epithelial wound closure, or whether there is a hierarchy of assembly that repairing basement membranes follow, similar to the hierarchy of assembly of embryonic basement membranes...
July 5, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29885460/adamts-proteins-in-human-disorders
#20
REVIEW
Timothy J Mead, Suneel S Apte
ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose substrates are extracellular matrix (ECM) components, whereas ADAMTS-like proteins lack a metalloprotease domain, reside in the ECM and have regulatory roles vis-à-vis ECM assembly and/or ADAMTS activity. Evolutionary conservation and expansion of ADAMTS proteins in mammals is suggestive of crucial embryologic or physiological roles in humans...
October 2018: Matrix Biology: Journal of the International Society for Matrix Biology
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