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Pathology International

Takashi Murakami, Hiroyuki Mitomi, Takashi Yao, Tsuyoshi Saito, Tomoyoshi Shibuya, Sumio Watanabe
Gastric neoplasia of the fundic gland (chief cell-predominant) type (GNCCP) is a rare variant of gastric tumor. This tumor is associated with activation of the Wnt/β-catenin signaling pathway; however, the mechanisms underlying this activation remain unknown. To elucidate potential roles of Wnt/β-catenin signal-associated gene methylation in GNCCP, we performed β-catenin immunostaining and methylation-specific polymerase chain reaction (PCR) for their associated genes, including SFRPs, APC, AXIN2, and MCC, in 26 GNCCPs [i...
January 20, 2017: Pathology International
Aurélie Beaufrère, Frédérique Larousserie, Safi Dokmak, Eric Pasmant, Janick Selves, Dominique Cazals-Hatem
No abstract text is available yet for this article.
January 20, 2017: Pathology International
Ping-Li Sun, Hironobu Sasano, Hongwen Gao
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Despite significant advances in its research of tumor biology and therapy, the prognosis for this neoplasm has still remained poor. The great majority of anticancer agents, regardless of their mechanisms of action, exert their lethal actions on cancer cells by inducing apoptosis following drug-induced cellular damage. Many reported studies have evaluated the prognostic and therapeutic implications of apoptosis in lung cancer, but their exact clinical value has remained unclear...
January 19, 2017: Pathology International
Ryo Taguchi, Kayoko Higuchi, Motohiro Sudo, Kenji Misawa, Takashi Miyamoto, Osamu Mishima, Morihisa Kitano, Koji Azuhata, Nobuo Ito
Ciliated muconodular papillary tumor (CMPT) is a rare papillary tumor that arises in the peripheral lung fields and is associated with the proliferation of ciliate d and goblet cells and increased mucin production. We report a case of CMPT involving the rearrangement of the anaplastic lymphoma kinase (ALK) gene. The patient was an 84-year-old Japanese female who had exhibited a small nodular shadow on chest computed tomography during a regular checkup 10 years ago. She underwent a partial resection of segment S10 of the right lung...
January 17, 2017: Pathology International
Masato Hayakawa, Ken Nishikura, Yoichi Ajioka, Yutaka Aoyagi, Shuji Terai
A total of 313 cases of differentiated-type early gastric adenocarcinomas, including 113 cases of small-sized carcinoma (5< × ≤10 mm) and 121 cases of microcarcinoma (0< × ≤5 mm), were examined immunohistochemically to clarify the phenotypic expressions. They were classified into four categories (gastric phenotype (G-type), intestinal phenotype, gastrointestinal phenotype, and null phenotype) by a two-step process: the phenotype based on an immunoprofile of mucin core proteins (MUCs) with CDX2 (w/...
January 15, 2017: Pathology International
Makoto Emori, Mitsuharu Tamakawa, Mitsunori Kaya, Kohichi Takada, Kazuyuki Murase, Chisa Fujita, Sayuri Sato, Ryuji Takahashi, Kanako C Hatanaka, Shintaro Sugita, Hiroshi Hirano, Toshihiko Yamashita, Tadashi Hasegawa
No abstract text is available yet for this article.
January 12, 2017: Pathology International
Hirokazu Kurohama, Yumi Mihara, Yasumori Izumi, Masatsugu Kamata, Seiji Nagashima, Atsumasa Komori, Yojiro Matsuoka, Nozomi Ueki, Masahiro Nakashima, Masahiro Ito
A 78-year-old man was admitted to our hospital for multiple lung and liver tumors. Initial clinical diagnosis was hepatocellular carcinoma (HCC) with lung metastases because of a high value of serum protein induced by vitamin K absence or antagonist II (PIVKA-II) (6,705 mAU/mL). However, a review of a prior CT showed the lung tumor had existed 6 months before liver tumors were detected. The tumors progressed rapidly and the patient died 37 days after admission. Autopsy revealed that both lung and liver tumors exhibited the histology of large cell neuroendocrine carcinoma (LCNEC)...
January 11, 2017: Pathology International
Maki Kanzawa, Tsuyoshi Sanuki, Manabu Onodera, Kohei Fujikura, Tomoo Itoh, Yoh Zen
Our objective is to elucidate the usefulness of maspin/p53 double immunostaining on biliary brushing cytology specimens. We first examined the expression of maspin in the biliary epithelium with variable degrees of dysplasia using surgically resected specimens (n = 56). Maspin appeared to be overexpressed in a stepwise manner from benign to malignant cholangiocytes: the reactive epithelium (20%), biliary intraepithelial neoplasia (~50%), and invasive cholangiocarcinomas (>90%). Next, an automated sequential double immunostaining protocol for maspin and p53 was applied to paraffin-embedded cell blocks of the biliary brushing cytology specimens obtained from 58 consecutive patients...
January 10, 2017: Pathology International
Hideya Kawasaki, Isao Kosugi, Shiori Meguro, Toshihide Iwashita
In humans, the herpes virus family member cytomegalovirus (CMV) is the most prevalent mediator of intrauterine infection-induced congenital defect. Central nervous system (CNS) dysfunction is a distinguishing symptom of CMV infection, and characterized by ventriculoencephalitis and microglial nodular encephalitis. Reports on the initial distribution of CMV particles and its receptors on the blood brain barrier (BBB) are rare. Nevertheless, several factors are suggested to affect CMV etiology. Viral particle size is the primary factor in determining the pattern of CNS infections, followed by the expression of integrin β1 in endothelial cells, pericytes, meninges, choroid plexus, and neural stem progenitor cells (NSPCs), which are the primary targets of CMV infection...
January 10, 2017: Pathology International
Georgia Karpathiou, Fabrice Guy Barral, Cyril Habougit, Vanessa Da Cruz, Fabien Forest, Olivier Collard, Michel Peoc'h
No abstract text is available yet for this article.
January 9, 2017: Pathology International
Kanako Nakayama, Hiroshi Yagata, Naoki Hayashi, Atsushi Yoshida, Junko Takei, Takuya Moriya, Koyu Suzuki, Hideko Yamauchi
No abstract text is available yet for this article.
December 23, 2016: Pathology International
Makoto Sano, Taku Homma, Toshiyuki Ishige, Nami Sawada, Shingo Ihara, Kosaku Kinoshita, Shinobu Masuda, Hiroyuki Hao
No abstract text is available yet for this article.
December 23, 2016: Pathology International
Hiroto Katoh, Shumpei Ishikawa
With the recent advances in genome sequencing technologies, comprehensive cancer genomic profiling has revealed the in-depth molecular mechanisms of gastric malignancies. New insights into the carcinogenesis pathways of gastric cancers have been acquired, not only by DNA sequencing, but also by the expression profiling of the transcriptome, the identification of chimeric genes, and epi-genetic profiling (such as DNA hypermethylation). Global genomic profiling of gastric cancers, in combination with histopathology, etiology, and cancer biology, has clarified that gastric cancers can be categorized into four subtypes with specific genomic characteristics...
December 22, 2016: Pathology International
Takeshi Masuda, Atsushi Takahashi
No abstract text is available yet for this article.
December 20, 2016: Pathology International
Kennichi Kakudo, Masami Asai, Yanhua Bai
No abstract text is available yet for this article.
December 20, 2016: Pathology International
Etan Marks, Sapna M Amin, Ling Xia, Joan Guitart, William Laskin
No abstract text is available yet for this article.
December 16, 2016: Pathology International
Payal Sojitra, Moon-Woo Nam, Reeba Omman, Milind M Velankar
No abstract text is available yet for this article.
December 15, 2016: Pathology International
Naoki Hijiya, Tomotaka Shibata, Tsutomu Daa, Ryoji Hamanaka, Tomohisa Uchida, Keiko Matsuura, Yoshiyuki Tsukamoto, Chisato Nakada, Hidekatsu Iha, Masafumi Inomata, Masatsugu Moriyama
In patients with esophageal squamous cell carcinoma (ESCC), the status of metastasis to lymph nodes is strongly associated with prognosis. Consequently, development of a biomarker to detect the presence of metastasis would be clinically valuable. In this study, we found that overexpression of cannabinoid receptor 1 (CB1R) was applicable as a marker for prediction of metastasis in ESCC. CB1R overexpression was detected immunohistochemically in 54 of 88 cases (61.4%). The intensity of CB1R expression was uniform in both intraepithelial and invasive regions in each case, and was significantly correlated with the status of metastasis to lymph nodes (P = 0...
December 15, 2016: Pathology International
Kimberly van der Oord, Heleen Rietema, Jan H von der Thusen, Eric Thunnissen
No abstract text is available yet for this article.
January 2017: Pathology International
Hideo Tanaka, Taka-Aki Matsuyama, Tetsuro Takamatsu
Cardiac arrhythmias have long been regarded as derangement of electrical impulse initiation and conduction within the heart. However, underlying mechanisms for arrhythmogenesis are not fully understood solely from the electrophysiological viewpoint. This review article discusses pathogenesis of arrhythmias from non-electrical aspects, which were elucidated by spatiotemporal imaging of functional molecules in combination with morphological analysis of living heart tissues. Intracellular Ca(2+) ([Ca(2+) ]i ) overload, caused by myocardial injury, provokes Ca(2+) waves that could lead to abnormal excitations, i...
January 2017: Pathology International
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