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Pathology International

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https://www.readbyqxmd.com/read/28508584/human-intestinal-spirochetosis-in-japanese-patients-aged-less-than-20-years-histological-analysis-of-colorectal-biopsy-and-surgical-specimens-obtained-from-479-patients
#1
Shojiro Ichimata, Akihiko Yoshizawa, Mai Kusakari, Yoshiko Nakayama, Shiho Asaka, Tatsuya Negishi, Eriko Kasuga, Takehisa Matsumoto, Takayuki Honda
Human intestinal spirochetosis (HIS) is a condition in which spirochetes attach to and colonize the colorectal epithelium. To our knowledge, no comprehensive studies of HIS in young patient have been published in a developed country. This study aimed to determine the incidence and clinicopathological manifestations of HIS in Japanese patients aged less than 20 years. We retrospectively reviewed 3605 biopsy and 92 surgical specimens obtained from 479 patients admitted to Shinshu University Hospital between 1997 and 2014...
May 15, 2017: Pathology International
https://www.readbyqxmd.com/read/28508463/ovarian-high-grade-endometrioid-stromal-sarcoma-with-ywhae-and-nutm2b-rearrangements
#2
LETTER
Noriaki Kikuchi, Shintaro Sugita, Katsuya Nakanishi, Taro Sugawara, Keiko Segawa, Yumika Ito, Terufumi Kubo, Hiromi Fujita, Hiroshi Hirano, Ryoichi Tanaka, Tsuyoshi Saito, Tadashi Hasegawa
No abstract text is available yet for this article.
May 15, 2017: Pathology International
https://www.readbyqxmd.com/read/28481030/pilomatrical-carcinosarcoma-of-the-cheek-immunohistochemical-and-molecular-analysis-of-beta-catenin
#3
LETTER
Takayuki Suyama, Shuji Momose, Megumi Yokoyama, Jun Kikuchi, Seiichi Izaki, Eiichi Arai, Junichi Tamaru
No abstract text is available yet for this article.
May 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28470939/expression-of-p16-ink4a-in-mixed-squamous-cell-and-glandular-papilloma-of-the-lung
#4
Ryo Miyoshi, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date
Mixed squamous cell and glandular papilloma (mixed papilloma) of the lung is an extremely rare neoplasm, with only 21 cases reported in the English literature. Although the expression of p16(Ink4a) has been analyzed in only two cases of mixed papilloma, they were negative for p16(Ink4a) . Therefore, the significance of p16(Ink4a) overexpression in mixed papilloma remains unclear. This is the first case of mixed papilloma with positive p16(Ink4a) expression in a 72-year-old male smoker. The 20 mm sized tumor was histologically diagnosed as mixed papilloma following right upper lobectomy...
May 3, 2017: Pathology International
https://www.readbyqxmd.com/read/28463437/primary-malignant-pericardial-sarcomatoid-mesothelioma-an-autopsy-report
#5
Hiroko Muta, Yasuo Sugita, Koichi Ohshima, Hitoshi Otsubo
Primary malignant pericardial sarcomatoid mesothelioma (PMPSM) is an extremely rare tumor with poor prognosis. We present an autopsy case in an 80-year-old man admitted for heart failure after one month of treatment at an outpatient clinic. He died three months after symptom onset. A complete autopsy revealed localization of the tumor to the pericardium without other lesions. Histologically, mainly spindle-shaped atypical cells with hyperchromatic nuclei and nucleoli were observed. Immunohistochemical markers for mesothelioma were positive for calretinin, cytokeratin AE1/AE3, and cytokeratin CAM5...
May 1, 2017: Pathology International
https://www.readbyqxmd.com/read/28440555/striated-duct-adenoma-presenting-with-intra-tumoral-hematoma-and-papillary-thyroid-carcinoma-like-histology
#6
Yohei Ito, Kana Fujii, Takayuki Murase, Kosuke Saida, Yoshihide Okumura, Hisashi Takino, Ayako Masaki, Shintaro Beppu, Daisuke Kawakita, Kei Ijichi, Hiroshi Inagaki
Striated duct adenoma of the salivary gland is a rare benign tumor characterized by unilayered duct epithelium and striations of the tumor cell membranes. To the best of our knowledge, only six cases have been reported in the literature. Here we report an additional case, which was complicated by an intra-tumoral hematoma on clinical presentation and by papillary thyroid carcinoma-like histology on intra-operative frozen section diagnosis. An asymptomatic 78-year-old male presented with a two-year-history of a painless tumor of the left parotid...
April 25, 2017: Pathology International
https://www.readbyqxmd.com/read/28422378/cellular-retinoic-acid-bioavailability-in-various-pathologies-and-its-therapeutic-implication
#7
REVIEW
Makoto Osanai
Retinoic acid (RA), an active metabolite of vitamin A, is a critical signaling molecule in various cell types. We found that RA depletion caused by expression of the RA-metabolizing enzyme CYP26A1 promotes carcinogenesis, implicating CYP26A1 as a candidate oncogene. Several studies of CYP26s have suggested that the biological effect of RA on target cells is primarily determined by "cellular RA bioavailability", which is defined as the RA level in an individual cell, rather than by the serum concentration of RA...
April 19, 2017: Pathology International
https://www.readbyqxmd.com/read/28419636/a-case-of-solitary-pulmonary-capillary-hemangioma-indicating-true-gross-appearance
#8
LETTER
Hirotsugu Hashimoto, Masahiro Yanagiya, Yoshio Suzuki, Masashi Kusakabe, Genki Usui, Jun Matsumoto, Hajime Horiuchi
No abstract text is available yet for this article.
April 17, 2017: Pathology International
https://www.readbyqxmd.com/read/28393435/pathogenetic-significance-and-possibility-as-a-therapeutic-target-of-platelet-derived-growth-factor
#9
REVIEW
Yoko Ishii, Takeru Hamashima, Seiji Yamamoto, Masakiyo Sasahara
Platelet-derived growth factor (PDGF) is one of the major mitogens and chemoattractants for mesenchymal and glial cells. Nowadays, the expression of PDGFs are recognized widely in our body, and emerging data indicate the relevance of PDGFs in the homeostatic control of systemic connective tissue as well as parenchymal cells such as neurons. Aberrant PDGF signal is primarily tumorigenic, and also regulates tumor microenvironments. The roles of the PDGF signal in tumorigenesis are diverse depending on the type of cancer, and anti-PDGF therapy needs to be carefully designed based on the information of each tumor cell type and the surrounding microenvironment...
April 10, 2017: Pathology International
https://www.readbyqxmd.com/read/28370778/clinical-and-pathological-significance-of-myeloid-differentiation-factor-88-expression-in-human-hepatocellular-carcinoma-tissues
#10
Keiichi Kinowaki, Yurie Soejima, Arisa Kumagai, Fukuo Kondo, Keiji Sano, Takeshi Fujii, Masanobu Kitagawa, Toshio Fukusato
The innate immune system, which includes toll-like receptor (TLR) signaling, plays an important role in inflammation and oncogenesis. Although TLR common adaptor myeloid differentiation factor 88 (MyD88) is known to have multiple effects on carcinogenesis, the role of MyD88 in hepatocarcinogenesis remains unknown. In this study, MyD88 expression was examined in 105 samples of human hepatocellular carcinoma (HCC) tissue by immunohistochemistry, Western blot, and quantitative reverse-transcriptase polymerase chain reaction methods...
April 3, 2017: Pathology International
https://www.readbyqxmd.com/read/28371144/laminar-crystal-deposition-in-large-vessels-in-a-patient-with-crystalglobulinemia
#11
Yukako Shintani-Domoto, Aya Shinozaki-Ushiku, Hidemi Okuma, Mineo Kurokawa, Masashi Fukayama
Crystalglobulinemia is an extremely rare complication of monoclonal gammopathy and is characterized by crystal thrombi within systemic organs. We herein report the first described case of crystalglobulinemia accompanied by laminar crystal deposition in the large vessels. A 44-year-old man presented with a history of numbness, pain, and swelling of the left leg in addition to visual impairment. Renal and skin biopsies revealed crystal thrombi within the capillary lumens. The patient was finally diagnosed with crystalglobulinemia associated with multiple myeloma...
March 31, 2017: Pathology International
https://www.readbyqxmd.com/read/28370814/l-type-amino-acid-transporter-1-expression-in-esophageal-carcinogenesis-according-to-who-and-japanese-classifications-of-intraepithelial-neoplasia
#12
Hirotsugu Hashimoto, Atsushi Kurata, Hiroyuki Kikuchi, Yoshio Masuda, Koji Fujita, Rikiya Okuyama, Shigeru Inoue, Hajime Horiuchi, Masahiko Kuroda
L-type amino acid transporter 1 (LAT1) has an essential role in cell proliferation especially in neoplasms. Although immunohistochemical expression of LAT1 has been investigated in invasive esophageal carcinoma, its expression in intraepithelial neoplasia (IEN) has not been reported. Further, classification of esophageal IEN is currently different between the World Health Organization (WHO) and Japanese criteria. Therefore, in this study, immunohistochemical expressions of LAT1 along with Ki-67 were analyzed in 66 esophageal samples of endoscopic submucosal dissection...
March 29, 2017: Pathology International
https://www.readbyqxmd.com/read/28337832/retroperitoneal-dedifferentiated-liposarcoma-with-huge-cystic-degeneration-a-case-report
#13
Kazuyoshi Uchihashi, Atsuji Matsuyama, Eisuke Shiba, Yoshizo Kimura, Toshiro Ogata, Kei Yabuki, Hiroshi Harada, Chisachi Kubo, Yojiro Tsuda, Mao Jotatsu, Masanori Hisaoka
Prominent cyst formation is an unusual feature of liposarcoma. We report here a case of dedifferentiated liposarcoma with huge cystic change without preoperative chemo- or radiation therapy. The lesion arose in the retroperitoneum juxtaposed to the right kidney of a 67-year-old woman. She underwent a surgical removal of the retroperitoneal cyst. The cystic tumor contained 1600 mL of old bloody fluid, and its wall was composed of edematous, inflamed or sclerosing fibrous tissue with fatty tissue containing abundant atypical stromal cells, which were immunohistochemically positive for MDM2 and CDK4, and demonstrated MDM2 gene amplification by fluorescence in situ hybridization...
March 23, 2017: Pathology International
https://www.readbyqxmd.com/read/28271635/a-case-of-ovarian-steroid-cell-tumor-with-bizarre-nuclear-atypia-and-ctnnb1-mutation
#14
Masaki Suzuki, Jun Matsushima, Takuya Yazawa, Satoshi Ota, Takako Kiyokawa, Hiroki Sonehara, Shinsuke Hanawa, Akira Mitsuhashi, Makio Shozu, Yukio Nakatani
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28271590/bizarre-stromal-cells-mimicking-malignancy-in-chondro-osseous-respiratory-epithelial-adenomatoid-hamartoma
#15
LETTER
Kyriakos Chatzopoulos, Marios Stavrakas, Prodromos Hytiroglou, Stefanos Triaridis
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28271585/renal-angiomyolipoma-with-para-aortic-lymph-node-involvement
#16
LETTER
Koto Kon-Nanjo, Youichiro Baba, Yuko Yoshio, Ryuichi Suzuki, Tomio Araki, Tetsuya Murata
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28370983/corrigendum
#17
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Pathology International
https://www.readbyqxmd.com/read/28261941/plaque-formation-and-the-intraneuronal-accumulation-of-%C3%AE-amyloid-in-alzheimer-s-disease
#18
REVIEW
Reisuke H Takahashi, Toshitaka Nagao, Gunnar K Gouras
Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-prone forms of Aβ. The findings of familial AD mutations in the APP gene suggest that Aβ plays a central role in the pathophysiology of AD...
April 2017: Pathology International
https://www.readbyqxmd.com/read/28261922/a-case-of-primary-aldosteronism-caused-by-unilateral-multiple-adrenocortical-micronodules-presenting-as-muscle-cramps-at-rest-the-importance-of-functional-histopathology-for-identifying-a-culprit-lesion
#19
Atsushi Ito, Yuto Yamazaki, Hironobu Sasano, Daisuke Matsubara, Noriyoshi Fukushima, Mio Tamba, Kenichi Tabata, Kentaro Ashizawa, Akihito Takei, Masaru Koizumi, Yasunaru Sakuma, Naohiro Sata, Hisashi Oshiro
Unilateral multiple adrenocortical micronodules (UMNs) constitute a rare subset of primary aldosteronism (PA) characterized by the hypersecretion of aldosterone derived from multiple small nodules in the zona glomerulosa of the unilateral adrenal grand. This case study describes a 49-year-old man with PA and UMNs who presented with muscle cramps at rest due to hypokalemia. The patient had a 6-year history of hypertension treated with antihypertensive drugs. Imaging studies revealed bilateral adrenal nodules as large as 5 mm...
April 2017: Pathology International
https://www.readbyqxmd.com/read/28213917/solid-pseudopapillary-neoplasm-expresses-inhibin-%C3%AE-and-tcf-3
#20
LETTER
Shirai Et Al, Yoko Shirai, Yasunori Enomoto, Toru Harada, Koji Asai, Shuichi Ashizuka, Masahiro Ikegami, Kei Takahashi, Norikazu Shimizu, Takashi Sekine
No abstract text is available yet for this article.
April 2017: Pathology International
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