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Pathology International

Yu Takahashi, Nobutake Yamamichi, Ken-Ichi Inada, Kazuya Shiogama, Kouhei Sakurai, Chihiro Takeuchi, Yasuyoshi Mizutani, Yutaka Tsutsumi, Kazuhiko Koike
Gastric cancer (GC) is rich in many different histological types, but how the histological pattern is defined remains to be proved. The relation between GC histological types and the expression of nectin1, which is one of the cell adhesion molecules that composes adherens junction, has not been reported. According to a publicly available database of 406 GC patients, the median overall survival of Nectin1 high expression patients was 55.4 months and that of low expression patients was 25.6 months (P = 0...
September 17, 2018: Pathology International
Yuuki Nishimura, Akihiko Yoshida, Kan Yonemori, Noriko Motoi, Kenji Tamura, Nobuyoshi Hiraoka, Taisuke Mori
SMARCB1-deficiency has been found in a variety of tumors. Here, we report a SMARCB1-deficient squamous cell carcinoma of a mediastinal cyst. A 53-year-old man was diagnosed with a cyst of the pericardial region in his twenties. As a symptom at this time, he complained of severe pain and dyspnea in the right chest. Following investigation using imaging and histological examination of the biopsy specimen, he was diagnosed with a SMARCB1 deficient malignant neoplasm. As tumor cells showed positive immunostaining for p40 and CK5/6, the immunophenotype of the tumor was consistent with squamous cell carcinoma (SCC)...
September 14, 2018: Pathology International
Burak Bahadır, Kemal Behzatoğlu, Ezgi Hacıhasanoğlu, Sevim Baykal Koca, Buket Bambul Sığırcı, Fatma Tokat
Lipomatous tumors accompanied by spindle cell component are not frequently encountered, and there are still problems regarding their differential diagnosis, nature, and nomenclature. To contribute to ongoing efforts, we present the clinical, histologic, and immunohistochemical characteristics of 20 cases of spindle cell lipomatous tumors with atypical features that may also be called atypical spindle cell/pleomorphic lipomatous tumors. Of the patients, 13 were men and 7 were women with an average age of 57...
September 9, 2018: Pathology International
Masayuki Shintaku, Yasuyuki Kamada, Masahiro Sumitomo
No abstract text is available yet for this article.
September 9, 2018: Pathology International
Tsunenori Kondo, Naoto Sasa, Hiroshi Yamada, Toshio Takagi, Junpei Iizuka, Hirohito Kobayashi, Kazuhiko Yoshida, Hironori Fukuda, Hiroki Ishihara, Kazunari Tanabe, Toyonori Tsuzuki
New pathological subtypes of renal cell carcinoma (RCC) were designated in the 2016 World Health Organization (WHO) classification corresponding to the features commonly seen in patients with end-stage renal disease (ESRD). To determine the clinicopathological findings of new subtypes, we reanalyzed all sections from 315 kidneys in 291 ESRD patients bearing RCC tumors surgically resected in three Japanese institutes by the central pathologist. Clear cell RCC was diagnosed in 144 kidneys (45.7%), acquired cystic disease (ACD)-associated RCC in 100 (31...
September 6, 2018: Pathology International
Tadashi Tabei, Yukio Tsuura, Kazuki Kobayashi
No abstract text is available yet for this article.
August 27, 2018: Pathology International
Shin Ichihara, Masashi Kawamura, Kingo Hirasawa, Kazuyoshi Yagi
No abstract text is available yet for this article.
August 22, 2018: Pathology International
Ayako Sakakibara, Emiko Takahashi, Eri Ishikawa, Kei Kohno, Naoko Asano, Shigeo Nakamura
No abstract text is available yet for this article.
August 9, 2018: Pathology International
Masayuki Shintaku, Toru Yoshida, Takanori Hirose
No abstract text is available yet for this article.
August 9, 2018: Pathology International
Vinod Gopalan, Kais Kasem, Suja Pillai, David Olveda, Armin Ariana, Melissa Leung, Alfred K Y Lam
This study aims to evaluate the impact on the implementation of multiple strategies to improve medical student's pathology learning experience. In two consecutive years, medical students after a whole year of enrolling in pathology teaching, were invited to complete questionnaires rating and commenting on the personal learning experience of multiple teaching resources delivered in pathology. In both years, the overall score was high (mean score = 4.57 ± 0.63 /5) for the newly introduced sessions, namely histology lectures, clinical integrations and virtual microscopy pre-practical sessions...
July 24, 2018: Pathology International
Tomoyuki Nakajima, Takeshi Uehara, Yukihiro Kobayashi, Yasuhiro Kinugawa, Kazuhiro Yamanoi, Yasuhiro Maruyama, Tomoaki Suga, Hiroyoshi Ota
LGR5 is expressed in various tumors and has been identified as a putative intestinal stem cell marker. Here we investigated LGR5 expression in colorectal neuroendocrine neoplasms and analyzed the correlation with pathological characteristics. We evaluated the clinicopathological features of 8 neuroendocrine tumor (NET) grade 1 (NET G1), 4 NET Grade 2 (NET G2), and 8 NET Grade 3 (NET G3; also termed neuroendocrine carcinoma, or NEC) cases. We examined LGR5 expression using an RNAscope, a newly developed RNA in situ hybridization technique, with a tissue microarray of the neuroendocrine neoplasm samples...
July 24, 2018: Pathology International
Junichi Kiyasu, Fumiko Arakawa, Shojiro Haji, Yoshimichi Tachikawa, Mariko Tsuda, Yasuhiro Tsukamoto, Motohiko Ikeda, Hiroki Muta, Takamitsu Matsushima, Hiroaki Miyoshi, Motoaki Shiratsuchi, Yoshihiro Ogawa, Kouichi Ohshima, Yuji Yufu
Although gamma heavy chain disease (γ-HCD) lesions occasionally morphologically resemble angioimmunoblastic T-cell lymphoma (AITL), no association has been described in detail due to the rarity of the disease. In this report, we present a rare manifestation of methotrexate (MTX)-associated lymphoproliferative disorders (LPDs) with AITL-like features accompanied by γ-HCD in a 75-year-old man with rheumatoid arthritis (RA). A biopsy specimen was evaluated using immunohistochemistry, clonal analyses of immunoglobulin VH and T-cell receptor γ gene rearrangements by polymerase chain reaction, and Sanger sequencing for confirmation of the structure of deleted γ-HCD clones...
July 10, 2018: Pathology International
Jun Miyauchi, Masaharu Ogura, Michio Sato, Junichi Matsui
Esophageal carcinosarcoma is a rare neoplasm with components of squamous cell carcinoma and sarcomatous spindle cell stroma. The latter may show overt mesenchymal differentiation but is thought to be derived from carcinoma cells in most cases. Here, we report a case of esophageal carcinosarcoma that appeared to be comprised of different origins of epithelial and mesenchymal tumor cells. The sarcomatous component formed an intralumial pedunculated large mass lesion that consisted of pleomorphic atypical histiocyte-like cells...
June 22, 2018: Pathology International
Yehonatan Gottlieb, Ronit Elhasid, Sivan Berger-Achituv, Eli Brazowski, Anat Yerushalmy-Feler, Shlomi Cohen
Neutrophil extracellular traps (NETs) are fibers composed of chromatin and neutrophil proteins released by activated neutrophils. NETs trap and kill microbes, activate dendritic and T cells, and are implicated in autoimmune and vascular diseases. The pathogenesis of inflammatory bowel disease (IBD) is multifactorial and characterized by chronic active mucosal inflammation with controversial contribution of neutrophils. Our aim is to describe the involvement of NETs in pediatric IBD. We retrospectively examined biopsies from the small bowel and colon of children at diagnosis of Crohn's disease (CD) or ulcerative colitis (UC)...
September 2018: Pathology International
Shinsuke Aida, Junko Aida, Miho Naoi, Mai Kato, Yukio Tsuura, Ichiro Natsume, Kaiyo Takubo
We estimated the telomere lengths of neoplastic and non-neoplastic mesothelial cells and examined their correlation with asbestos exposure and the expression of markers of mesothelial malignancy. Cell blocks of pleural effusion obtained from 35 cases of non-neoplastic disease (NN), 12 cases of malignant mesothelioma (MM) and 12 cases of carcinomatous effusion due to lung adenocarcinoma (LA) were examined. Fifteen of the 35 NN cases had pleural plaques (NNpp+) suggestive of asbestos exposure, and the other 20 cases had no pleural plaques (NNpp-)...
September 2018: Pathology International
Boram Song, Kyoungbun Lee, Cheol Lee, Kyung Chul Moon
Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) frequently display infiltrative growth into the adjacent normal soft tissue. In this study, we aimed to determine whether the microscopic extension into surrounding normal tissue can influence the local recurrence of MFS and UPS. A total of 42 cases (22 MFS and 20 UPS) were examined. The length of the microscopic extension was measured from the edge of the main tumor mass to the end of infiltration. The length of 5.5 mm was selected as the optimal cut-off value that could predict local recurrence using the receiver operating characteristic (ROC) curve and Youden index...
September 2018: Pathology International
Kosuke Miyai, Hiroaki Takeo, Takefumi Nakayama, Kiyohaya Obara, Shinsuke Aida, Kimiya Sato, Susumu Matsukuma
We report a case of a 67-year-old woman with an invasive ciliated muconodular papillary tumor (CMPT) that developed in her right middle lobe. The current tumor was incidentally detected during a follow-up imaging examination for a large cell carcinoma that was resected 10 years previously. Partial removal of the middle lobe showed a 2 cm-sized, solid and myxoid tumor located in the peripheral region. Histologically, this tumor primarily consisted of ciliated columnar cells, mucous cells, and basal cells, all of which had relatively swollen nuclei and were proliferating in a lepidic or papillary/micropapillary manner...
September 2018: Pathology International
Toshiki Hyodo, Maki Kanzawa, Shigeo Hara, Kosuke Takahashi, Satoshi Ogawa, Junya Furukawa, Masato Fujisawa, Anna Kobayashi, Naoto Kuroda, Tomoo Itoh
Renal cell carcinoma (RCC) occasionally has sarcomatoid differentiation and rarely contains heterologous components. We report a case of chromophobe RCC with sarcomatoid differentiation that had various heterologous components including a unique lipomatous area. The patient was an 83-year-old woman with a palpable mass in the left lower abdomen. Grossly, the tumor was 14 cm in diameter and had yellowish-to-whitish color with focal necrosis and hemorrhage. Histologically, the tumor was composed of an eosinophilic subtype of chromophobe RCC with sarcomatoid differentiation including mainly chondrosarcoma, some osteosarcoma and a lipomatous area...
September 2018: Pathology International
Marini Stephanie, Rie Irie, Kengo Sasaki, Yoshihiro Hirata, Soichi Narumoto, Akinari Fukuda, Seisuke Sakamoto, Katsuhiro Arai, Takako Yoshioka, Mureo Kasahara
No abstract text is available yet for this article.
September 2018: Pathology International
Vinicius Carrera Souza, Christiana de Freitas Vinhas, Diego Miguel, Daniel Abensur Athanazio, Kiril Trpkov
No abstract text is available yet for this article.
September 2018: Pathology International
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