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Pathology International

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https://www.readbyqxmd.com/read/30417961/-integrated-diagnosis-of-pilocytic-astrocytoma-molecular-diagnostic-procedure-for-an-unusual-case
#1
Yusuke Ishida, Masumi Tsuda, Yutaka Sawamura, Kyoko Fujii, Hiroshi Murai, Naruyoshi Horiuchi, Yasuko Orba, Hirofumi Sawa, William W Hall, Kazuo Nagashima, Shinya Tanaka
A 24 year-old female presented with a mass lesion in the right temporal lobe. This case was difficult to diagnose using histological and immunological methods and therefore molecular analyses were applied to provide a definitive diagnosis. The tumor was well-demarcated, partially cystic, and irregularly-enhanced on gadolinium-enhanced T1-weighted magnetic resonance images. Pathologically, a large part of the tumor consisted of cells with fine cytoplasmic processes on a myxoid and mucinous background. Cells formed a microcystic structure around the mucinous tissue...
November 12, 2018: Pathology International
https://www.readbyqxmd.com/read/30417956/adenosquamous-carcinoma-of-the-papilla-of-vater-a-phenotypic-heterogeneity-characterized-by-a-common-molecular-landscape
#2
LETTER
Anna Caterina Milanetto, Liço Valbona, Rita Alaggio, Giada Munari, Sergio Pedrazzoli, Matteo Fassan, Claudio Pasquali
No abstract text is available yet for this article.
November 12, 2018: Pathology International
https://www.readbyqxmd.com/read/30402988/recurrent-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-with-aberrant-cd20-expression-an-implication-for-anti-cd20-rituximab-antibody-therapy
#3
LETTER
Pi-Han Liao, Shih-Cheng Chou, Wan-Ting Huang, Ying-Zhen Su, Ming-Chung Wang, Shih-Sung Chuang
No abstract text is available yet for this article.
November 6, 2018: Pathology International
https://www.readbyqxmd.com/read/30376202/aggressive-cribriform-morular-variant-of-papillary-thyroid-carcinoma-report-of-an-unusual-case-with-pulmonary-metastasis-displaying-poorly-differentiated-features
#4
Hiromi Tsuji, Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Takashi Hiroshima, Yasushi Sakamaki, Akira Miyauchi, Masahiko Tsujimoto
The cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity in which metastasis rarely occurs. Until now, only three cases of metastasis by CMV-PTC have been reported. We present a rare sporadic case of CMV-PTC with multiple lung metastases in a 28-year-old female, 3 years after total thyroidectomy. The lung tumor was not encapsulated but well-circumscribed and showed a mixture of cribriform, papillary, and solid patterns of growth with necrosis. The tall columnar carcinoma cells did not display the typical nuclear features of PTC...
October 30, 2018: Pathology International
https://www.readbyqxmd.com/read/30362654/nut-carcinoma-clinicopathologic-features-pathogenesis-and-treatment
#5
REVIEW
Christopher A French
NUT carcinoma (NC) is a rare, aggressive subtype of squamous cell carcinoma defined by rearrangement of the NUTM1 (aka NUT) gene. NC is driven by NUT-fusion oncoproteins resulting from chromosomal translocation, most commonly BRD4-NUT. This is a nearly uniformly lethal cancer affecting patients of all ages, but predominantly teens and young adults. The cell of origin is unknown, but NC most commonly arises within the thorax and head and neck. NC typically consists of sheets of monomorphic primitive round cells that can exhibit focal abrupt squamous differentiation...
November 2018: Pathology International
https://www.readbyqxmd.com/read/30350394/diagnostic-value-of-hbme-1-ck19-galectin-3-and-cd56-in-the-subtypes-of-follicular-variant-of-papillary-thyroid-carcinoma
#6
Haeyon Cho, Ji-Ye Kim, Young Lyun Oh
Our aim is to explore differences in Hector Battifora mesothelial-1 (HBME-1), cytokeratin-19 (CK19), Galectin-3 (Gal-3), and CD56 expression in infiltrative follicular variants of papillary carcinoma (IFVPTC) and encapsulated follicular variants of papillary carcinoma (EFVPTC) and to provide clues for distinguishing the two subtypes preoperatively. Tissue microarrays from 100 EFVPTC (45 non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) and 55 invasive EFVPTCs), 43 IFVPTCs, and 64 follicular neoplasms (FN) were immunostained with HBME-1, CK19, Gal-3, and CD56...
November 2018: Pathology International
https://www.readbyqxmd.com/read/30320419/high-expression-of-ovarian-cancer-immunoreactive-antigen-domain-containing-2-ociad2-is-associated-with-poor-prognosis-in-lung-adenocarcinoma
#7
Mai Sakashita, Shingo Sakashita, Yoshihiko Murata, Aya Shiba-Ishii, Yunjung Kim, Ryota Matsuoka, Noriyuki Nakano, Yukio Sato, Masayuki Noguchi
The clinicopathological implications of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) in lung adenocarcinoma were investigated. The expression of OCIAD2 in 191 surgically resected lung adenocarcinomas was examined using immunohistochemistry. OCIAD2 expression was quantified using the H-score and dichotomized as high or low. High OCIAD2 protein expression was significantly correlated with vascular invasion (P = 0.0018), lymphatic permeation (P = 0.049), T factor (P = 0.0024), and pathological stage (P = 0...
November 2018: Pathology International
https://www.readbyqxmd.com/read/30311995/a-case-of-combined-small-cell-lung-carcinoma-with-unique-morphology-investigation-of-tumorigenesis
#8
Miki Asahina, Yuki Fukumura, Osman Mamat, Tsuyoshi Saito, Takuo Hayashi, Toshimasa Uekusa, Kenji Suzuki, Takashi Yao
Small cell lung carcinoma (SCLC) usually grows in a pure form with no other associated histological components. However, combined small cell lung carcinoma (cSCLC), which is accompanied by other histological components (cSCLCs) may sometimes occur. Herein, we analyzed the tumorigenesis of cSCLC containing a demarcated area of pure SCLC. A 76-year-old man had a 25-mm mass in the perihilar portion of his right upper lung. Histologically, the cSCLC contained two relatively demarcated areas: one area composed of pure SCLC cells and another area of SCLC, squamous-like component (SLC), and spindle cell carcinoma (SpCC) cells...
November 2018: Pathology International
https://www.readbyqxmd.com/read/30255584/synchronous-case-of-follicular-lymphoma-and-langerhans-cell-sarcoma-in-the-same-lymph-node
#9
Joji Shimono, Hiroaki Miyoshi, Fumiko Arakawa, Hideyuki Abe, Takuto Miyagishima, Jun Akiba, Takanori Teshima, Koichi Ohshima
Langerhans cell sarcoma (LCS) is a very rare histiocytic and dendritic cell neoplasm originating from Langerhans cells. There are case reports of histiocytic and dendritic cell neoplasms synchronously or sequentially observed in patients with malignant lymphoma. We present a case in which LCS and follicular lymphoma (FL) grade 3a were observed within the same lymph node. A 66-year-old male visited our hospital with a general malaise. Pleural effusion and systemic lymph adenopathy were detected. Biopsy of an inguinal lymph node was performed...
November 2018: Pathology International
https://www.readbyqxmd.com/read/30239063/feasibility-of-methylome-analysis-using-small-amounts-of-genomic-dna-from-formalin-fixed-paraffin-embedded-tissue
#10
LETTER
Kentaro Ohara, Eri Arai, Yoriko Takahashi, Yukihiro Fukamachi, Nanako Ito, Akiko Miyagi Maeshima, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai
No abstract text is available yet for this article.
November 2018: Pathology International
https://www.readbyqxmd.com/read/30198090/m%C3%A3-llerian-carcinosarcoma-with-neuroendocrine-differentiation-arising-in-hydrocele-of-the-canal-of-nuck
#11
LETTER
Masayuki Shintaku, Yasuyuki Kamada, Masahiro Sumitomo
No abstract text is available yet for this article.
November 2018: Pathology International
https://www.readbyqxmd.com/read/30151940/pseudoprogression-a-case-of-metastatic-renal-clear-cell-carcinoma-treated-with-nivolumab
#12
LETTER
Tadashi Tabei, Yukio Tsuura, Kazuki Kobayashi
No abstract text is available yet for this article.
November 2018: Pathology International
https://www.readbyqxmd.com/read/30136360/muc6-positive-cell-proliferation-in-the-glandular-neck-zone-of-low-grade-well-differentiated-carcinoma
#13
LETTER
Shin Ichihara, Masashi Kawamura, Kingo Hirasawa, Kazuyoshi Yagi
No abstract text is available yet for this article.
November 2018: Pathology International
https://www.readbyqxmd.com/read/30246385/gliosarcoma-arising-from-oligodendroglioma-oligosarcoma-a-case-report-with-genetic-analyses
#14
Shunya Tanaka, Tsutomu Hitotsumatsu, Yasuo Sugita, Katsuya Ishido, Osamu Ito, Ryusuke Hatae, Yojiro Akagi, Koji Yoshimoto, Koji Iihara
Gliosarcomas are a type of bimorphic tumor composed of glial and sarcomatous elements, and are considered to be a variant of glioblastoma, WHO grade IV. To date, only rare cases of gliosarcoma with oligodendroglial components (oligosarcoma) have been reported. We report a case of oligosarcoma consisting of gliosarcoma arising from recurrent oligodendroglioma. A 53-year-old man, who had undergone a gross total resection of oligodendroglioma (WHO grade II) 11 years earlier, presented with a local tumor recurrence...
October 2018: Pathology International
https://www.readbyqxmd.com/read/30221498/nectin1-expression-is-frequently-decreased-in-gastric-cancers
#15
Yu Takahashi, Nobutake Yamamichi, Ken-Ichi Inada, Kazuya Shiogama, Kouhei Sakurai, Chihiro Takeuchi, Yasuyoshi Mizutani, Yutaka Tsutsumi, Kazuhiko Koike
Gastric cancer (GC) is rich in many different histological types, but how the histological pattern is defined remains to be proved. The relation between GC histological types and the expression of nectin1, which is one of the cell adhesion molecules that composes adherens junction, has not been reported. According to a publicly available database of 406 GC patients, the median overall survival of Nectin1 high expression patients was 55.4 months and that of low expression patients was 25.6 months (P = 0...
October 2018: Pathology International
https://www.readbyqxmd.com/read/30216599/smarcb-1-deficient-squamous-cell-carcinoma-of-a-mediastinal-cyst
#16
Yuuki Nishimura, Akihiko Yoshida, Kan Yonemori, Noriko Motoi, Kenji Tamura, Nobuyoshi Hiraoka, Taisuke Mori
SMARCB1-deficiency has been found in a variety of tumors. Here, we report a SMARCB1-deficient squamous cell carcinoma of a mediastinal cyst. A 53-year-old man was diagnosed with a cyst of the pericardial region in his twenties. As a symptom at this time, he complained of severe pain and dyspnea in the right chest. Following investigation using imaging and histological examination of the biopsy specimen, he was diagnosed with a SMARCB1 deficient malignant neoplasm. As tumor cells showed positive immunostaining for p40 and CK5/6, the immunophenotype of the tumor was consistent with squamous cell carcinoma (SCC)...
October 2018: Pathology International
https://www.readbyqxmd.com/read/30198097/atypical-spindle-cell-pleomorphic-lipomatous-tumor-a-clinicopathologic-immunohistochemical-and-molecular-study-of-20-cases
#17
Burak Bahadır, Kemal Behzatoğlu, Ezgi Hacıhasanoğlu, Sevim Baykal Koca, Buket Bambul Sığırcı, Fatma Tokat
Lipomatous tumors accompanied by spindle cell component are not frequently encountered, and there are still problems regarding their differential diagnosis, nature, and nomenclature. To contribute to ongoing efforts, we present the clinical, histologic, and immunohistochemical characteristics of 20 cases of spindle cell lipomatous tumors with atypical features that may also be called atypical spindle cell/pleomorphic lipomatous tumors. Of the patients, 13 were men and 7 were women with an average age of 57...
October 2018: Pathology International
https://www.readbyqxmd.com/read/30187581/acquired-cystic-disease-associated-renal-cell-carcinoma-is-the-most-common-subtype-in-long-term-dialyzed-patients-central-pathology-results-according-to-the-2016-who-classification-in-a-multi-institutional-study
#18
Tsunenori Kondo, Naoto Sasa, Hiroshi Yamada, Toshio Takagi, Junpei Iizuka, Hirohito Kobayashi, Kazuhiko Yoshida, Hironori Fukuda, Hiroki Ishihara, Kazunari Tanabe, Toyonori Tsuzuki
New pathological subtypes of renal cell carcinoma (RCC) were designated in the 2016 World Health Organization (WHO) classification corresponding to the features commonly seen in patients with end-stage renal disease (ESRD). To determine the clinicopathological findings of new subtypes, we reanalyzed all sections from 315 kidneys in 291 ESRD patients bearing RCC tumors surgically resected in three Japanese institutes by the central pathologist. Clear cell RCC was diagnosed in 144 kidneys (45.7%), acquired cystic disease (ACD)-associated RCC in 100 (31...
October 2018: Pathology International
https://www.readbyqxmd.com/read/30094900/neoplastic-pd-l1-expression-on-interdigitating-dendritic-cell-sarcoma-a-supplementary-study-of-a-case-report
#19
LETTER
Ayako Sakakibara, Emiko Takahashi, Eri Ishikawa, Kei Kohno, Naoko Asano, Shigeo Nakamura
No abstract text is available yet for this article.
October 2018: Pathology International
https://www.readbyqxmd.com/read/30094897/dedifferentiated-liposarcoma-of-the-spermatic-cord-with-features-of-epithelioid-rhabdomyosarcoma-and-a-rapidly-fatal-outcome
#20
LETTER
Masayuki Shintaku, Toru Yoshida, Takanori Hirose
No abstract text is available yet for this article.
October 2018: Pathology International
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