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Pathology International

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https://www.readbyqxmd.com/read/29465792/uterine-adenomatoid-tumor-containing-epithelioid-oxyphilic-cells-showing-prominent-down-expression-of-hbme1-and-increased-ki-67-labeling-index
#1
LETTER
Hirotsugu Hashimoto, Yuko Sasajima, Tamaki Miura, Hironori Ninomiya, Masashi Kusakabe, Hajime Tsunoda, Hajime Horiuchi
No abstract text is available yet for this article.
February 21, 2018: Pathology International
https://www.readbyqxmd.com/read/29465761/tumor-deposits-in-salivary-gland-tumors
#2
Sulen Sarioglu, Emel Kilicarslan, Barbaros Aydin, Melih Arif Kozen, Fadime Akman, Ilhan Oztop, Emel Ada, Ahmet Omer Ikiz
Tumor deposits (TDs), identified in different types of carcinomas are associated with poor prognosis. Salivary gland tumors were evaluated for the first time for TDs in this series. Pathological and clinical features of 25 salivary gland carcinomas primarily treated surgically including neck dissection were determined and all cases were evaluated for TDs in dissection specimens. Seven patients (28%) had TDs. There was no difference for TDs when histological type, tumor grade, tumor localization, pT, pN stage, surgical margin, lymphovascular, perineural invasion, local recurrence, distant metastatic disease and overall survival were considered...
February 21, 2018: Pathology International
https://www.readbyqxmd.com/read/29465759/development-of-a-method-to-preliminarily-embed-tissue-samples-using-low-melting-temperature-fish-gelatin-before-sectioning-a-technical-note
#3
Kaori Ushida, Naoya Asai, Kozo Uchiyama, Atsushi Enomoto, Masahide Takahashi
Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap-freezing followed by microtome or cryostat sectioning; and (ii) agarose embedding followed by cutting on a vibrating microslicer. Although these methods are useful for routine laboratory work, preparation of small and fragile tissues such as mouse organs, small human biopsy samples, and cultured floating spheres is difficult and requires special skills...
February 21, 2018: Pathology International
https://www.readbyqxmd.com/read/29457859/post-infectious-acute-glomerulonephritis-with-podocytopathy-induced-by-parvovirus-b19-infection
#4
Satoshi Hara, Masayoshi Hirata, Kiyoaki Ito, Ichiro Mizushima, Hiroshi Fujii, Kazunori Yamada, Michio Nagata, Mitsuhiro Kawano
Human parvovirus B19 infection causes a variety of glomerular diseases such as post-infectious acute glomerulonephritis and collapsing glomerulopathy. Although each of these appears independently, it has not been fully determined why parvovirus B19 provokes such a variety of different glomerular phenotypes. Here, we report a 68-year-old Japanese man who showed endocapillary proliferative glomerulonephritis admixed with podocytopathy in association with parvovirus B19 infection. The patient showed acute onset of heavy proteinuria, microscopic hematuria and kidney dysfunction with arthralgia and oliguria after close contact with a person suffering from erythema infectiosum...
February 19, 2018: Pathology International
https://www.readbyqxmd.com/read/29457853/mesenchymal-epithelial-transition-of-pancreatic-cancer-cells-at-perineural-invasion-sites-is-induced-by-schwann-cells
#5
Yoko Fujii-Nishimura, Ken Yamazaki, Yohei Masugi, Junya Douguchi, Yutaka Kurebayashi, Naoto Kubota, Hidenori Ojima, Minoru Kitago, Masahiro Shinoda, Akinori Hashiguchi, Michiie Sakamoto
Epithelial-mesenchymal transition (EMT) promotes invasion and metastasis of pancreatic ductal adenocarcinoma (PDAC). However, the importance of its reverse process, mesenchymal-epithelial transition (MET), for PDAC remains unclear. We aimed to characterize the histological finding "focal differentiation" in PDAC at perineural invasion sites in the context of MET and to investigate the role of Schwann cells in inducing tumor MET. Tumor differentiation and immunohistochemical expressions of E-cadherin, SMAD3, and vimentin at perineural invasion sites were examined in 168 PDAC tissues...
February 19, 2018: Pathology International
https://www.readbyqxmd.com/read/29451347/a-rare-case-of-ectopic-papillary-thyroid-carcinoma-transformed-into-squamous-cell-carcinoma
#6
Hironao Yasuoka, Yasushi Nakamura, Ken-Ichi Yoshida, Toshiro Shimo, Masayuki Tori, Yuuki Matsui, Yasushi Sakamaki, Masahiko Tsujimoto
A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. During the post-operative follow-up period, a rapidly growing 2 cm nodular lesion in the lower left lobe of the lung was detected...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29451344/a-case-of-microscopic-multiple-sclerosing-pneumocytoma
#7
Hitomi Kawai, Norio Takayashiki, Haruo Otani, Shingo Sakashita, Masayuki Noguchi
Sclerosing pneumocytoma is a rare tumor of the lung, commonly affecting middle-aged women, and is mostly isolated. Although this tumor is thought to be derived from primitive respiratory epithelial cells, the characteristics of the precursor cells are still unknown. A 19-year-old woman presented with multiple nodules in the right lung. Partial resection of the right middle lobe was performed, and seven sclerosing pneumocytomas, including four that were microscopic, were detected. The latter showed a simple papillary pattern, and three of them consisted of only round cell-like cells (single population)...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29446862/primary-enteric-type-tubulovillous-adenocarcinoma-arising-in-the-renal-pelvis
#8
LETTER
Akihiro Shioya, Katsuhiko Saito, Nozomu Kurose, Yasukazu Takase, Koichi Kodama, Hiroshi Minato, Takayuki Nojima, Sohsuke Yamada
No abstract text is available yet for this article.
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29446856/thyroid-carcinoma-producing-%C3%AE-human-chorionic-gonadotropin-shows-different-clinical-behavior
#9
Haiyan Gu, Shaofeng Sui, Xiujie Cui, Bo Han, Chunyan Zhang, Mei Qi, Congcong Li, Zhiyan Liu
Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. On the contrary, positive immunoreaction with β-hCG was proved in three anaplastic thyroid carcinoma patients showing aggressive clinical courses...
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29446522/a-dedifferentiated-liposarcoma-with-inflammatory-myofibroblastic-tumor-like-features
#10
LETTER
Keita Kai, Kazuma Udo, Ken Yamaguchi, Shohei Tobu, Mitsuru Noguchi, Shinichi Aishima
No abstract text is available yet for this article.
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29446516/a-rare-case-of-uterine-tumor-resembling-ovarian-sex-cord-tumor-with-necrosis-and-increased-mitotic-activity
#11
LETTER
Nomoto Kazuhiro
No abstract text is available yet for this article.
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29446514/giant-cell-rich-osteosarcoma-of-the-vertebra-with-murine-double-minute-chromosome-2-and-cyclin-dependent-kinase-4-positive-and-histone-h3f3a-mutant-p-gly34trp-negative-immunophenotypes
#12
LETTER
Yumika Ito, Shintaro Sugita, Keiko Segawa, Taro Sugawara, Mitsuhiro Tsujiwaki, Hiromi Fujita, Yusuke Ono, Tomonori Morita, Makoto Emori, Tadashi Hasegawa
No abstract text is available yet for this article.
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29437276/editorial-comment-on-validation-of-the-digital-pcr-system-for-use-in-tyrosine-kinase-inhibitor-resistant-egfr-mutant-non-small-cell-lung-cancer
#13
EDITORIAL
Haruhiko Sugimura, Tomoaki Kahyo
No abstract text is available yet for this article.
February 13, 2018: Pathology International
https://www.readbyqxmd.com/read/29431273/hepatocyte-growth-factor-activator-inhibitors-hai-1-and-hai-2-emerging-key-players-in-epithelial-integrity-and-cancer
#14
REVIEW
Hiroaki Kataoka, Makiko Kawaguchi, Tsuyoshi Fukushima, Takeshi Shimomura
The growth, survival, and metabolic activities of multicellular organisms at the cellular level are regulated by intracellular signaling, systemic homeostasis and the pericellular microenvironment. Pericellular proteolysis has a crucial role in processing bioactive molecules in the microenvironment and thereby has profound effects on cellular functions. Hepatocyte growth factor activator inhibitor type 1 (HAI-1) and HAI-2 are type I transmembrane serine protease inhibitors expressed by most epithelial cells...
February 12, 2018: Pathology International
https://www.readbyqxmd.com/read/29431240/the-prognostic-significance-of-n-myc-downregulated-gene-1-in-lung-adenocarcinoma
#15
Tomoko Dai, Yuichi Dai, Yoshihiko Murata, Ryan Edbert Husni, Noriyuki Nakano, Shingo Sakashita, Masayuki Noguchi
It has been reported that N-myc downstream regulated gene 1 (NDRG1) is related to the prognosis of non-small cell lung cancer (NSCLC), and associated with c-Myc degradation in NSCLC cell lines. However, the relationship of NDRG1 to prognosis or c-Myc expression in lung adenocarcinoma has not been well clarified. The present study was designed to investigate the prognostic significance of NDRG1 and/or c-Myc expression in lung adenocarcinoma using immunohistochemistry with a tissue microarray. We examined 184 lung adenocarcinomas and observed low expression of NDRG1 in adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), whereas high expression of NDRG1 was seen in invasive adenocarcinoma...
February 12, 2018: Pathology International
https://www.readbyqxmd.com/read/29431238/basigin-expression-as-a-prognostic-indicator-in-stage-i-pulmonary-adenocarcinoma
#16
Toshihide Matsumoto, Ryo Nagashio, Shinichiro Ryuge, Satoshi Igawa, Makoto Kobayashi, Eriko Fukuda, Naoki Goshima, Masaaki Ichinoe, Shi-Xu Jiang, Yukitoshi Satoh, Noriyuki Masuda, Yoshiki Murakumo, Makoto Saegusa, Yuichi Sato
We established the KU-Lu-8 monoclonal antibody (MoAb) using a lung cancer cell line as an antigen and a random immunization method. The KU-Lu-8 MoAb recognizes basigin (BSG), which is a transmembrane-type glycoprotein that is strongly expressed on the cell membranes of lung cancer cells. This study aimed to clarify the relationships between BSG expression and clinicopathological parameters and determine the prognostic significance of BSG expression in pulmonary adenocarcinoma (AC) patients. To evaluate the significance of BSG expression in lung cancer, we immunohistochemically analyzed 113 surgically resected pulmonary adenocarcinomas, and the associations between BSG expression and various clinicopathological parameters were evaluated...
February 12, 2018: Pathology International
https://www.readbyqxmd.com/read/29393583/mitosis-count-and-number-of-cancer-cells-in-cases-of-primary-pulmonary-adenocarcinoma-correlations-among-phosphorylated-histone-3-number-of-cancer-cells-nuclear-grade-pathologic-features-and-prognosis
#17
Takashi Inoue, Yoshimasa Nakazato, Yoko Karube, Sumiko Maeda, Satoru Kobayashi, Masayuki Chida
Immunohistochemistry findings for the phosphorylated form of histone 3 (pHH3) have been shown to be a reliable mitosis-specific marker. We evaluated the correlation between pHH3-stained mitotic figures (PHMFs) and clinical outcome, and compared the results with findings for numbers of PHMFs and cancer cells. The primary tumor was obtained from 113 patients with pulmonary adenocarcinomas (≤2 cm maximum dimension). All specimens were stained with pHH3, then the number of cancer cells in each was determined...
February 2, 2018: Pathology International
https://www.readbyqxmd.com/read/29393560/histopathology-of-immature-ongoing-squamous-metaplasia-of-the-stomach
#18
LETTER
Takashi Oide, Motoyasu Kan, Atsuko Masunaga, Takayoshi Nishino, Kenzo Hiroshima
No abstract text is available yet for this article.
February 2, 2018: Pathology International
https://www.readbyqxmd.com/read/29377340/nuclear-pseudoinclusions-in-melanoma-cells-prognostic-fact-or-artifact-the-possible-role-of-golgi-phosphoprotein-3-overexpression-in-nuclear-pseudoinclusions-generation
#19
Piotr Donizy, Maciej Kaczorowski, Przemyslaw Biecek, Agnieszka Halon, Rafal Matkowski
Nuclear pseudoinclusions (NPIs) are classically found in papillary thyroid carcinoma and meningioma. Although NPIs have been described in melanocytic lesions, there is no systematic analysis of potential relationship between NPIs and other clinicopathological characteristics of melanoma. We examined the presence of NPIs in H&E-stained tissue sections form 96 melanomas and analyzed statistical associations with important clinicopathological parameters and tissue immunoreactivity for selected proteins involved in epithelial-mesenchymal transition (SPARC, N-cadherin), cell adhesion and mobility (ALCAM, ADAM-10), regulation of mitosis (PLK1), cell survival (FOXP1) and functioning of Golgi apparatus (GOLPH3, GP73)...
January 29, 2018: Pathology International
https://www.readbyqxmd.com/read/29368414/stromal-tiny-black-dots-like-sugar-coated-of-von-kossa-stain-is-a-diagnostic-clue-to-hyalinizing-trabecular-tumor-of-the-thyroid-gland
#20
Rumi Hino, Noriko Motoi, Kazutoshi Toda, Aya Ebina, Keiko Yamada, Miyoko Higuchi, Mitsuyoshi Hirokawa, Yuichi Ishikawa
Hyalinizing trabecular tumor (HTT) is a rare low-grade tumor, and a prominent feature is the basement membranous stroma. We assume that such characteristic stromal findings of HTT are related to calcium deposition, and examined HTT samples by von Kossa special staining. There has been no report describing von Kossa special staining for such stroma. We collected 12 cases of HTT and 30 cases of papillary thyroid carcinoma (PTC) that had matched age, gender, tumor size, and surgical procedure characteristics as a control group...
January 24, 2018: Pathology International
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