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Pathology International

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https://www.readbyqxmd.com/read/28271635/a-case-of-ovarian-steroid-cell-tumor-with-bizarre-nuclear-atypia-and-ctnnb1-mutation
#1
Masaki Suzuki, Jun Matsushima, Takuya Yazawa, Satoshi Ota, Takako Kiyokawa, Hiroki Sonehara, Shinsuke Hanawa, Akira Mitsuhashi, Makio Shozu, Yukio Nakatani
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28271590/bizarre-stromal-cells-mimicking-malignancy-in-chondro-osseous-respiratory-epithelial-adenomatoid-hamartoma
#2
LETTER
Kyriakos Chatzopoulos, Marios Stavrakas, Prodromos Hytiroglou, Stefanos Triaridis
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28271585/renal-angiomyolipoma-with-para-aortic-lymph-node-involvement
#3
LETTER
Koto Kon-Nanjo, Youichiro Baba, Yuko Yoshio, Ryuichi Suzuki, Tomio Araki, Tetsuya Murata
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28261941/plaque-formation-and-the-intraneuronal-accumulation-of-%C3%AE-amyloid-in-alzheimer-s-disease
#4
REVIEW
Reisuke H Takahashi, Toshitaka Nagao, Gunnar K Gouras
Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-prone forms of Aβ. The findings of familial AD mutations in the APP gene suggest that Aβ plays a central role in the pathophysiology of AD...
March 5, 2017: Pathology International
https://www.readbyqxmd.com/read/28261922/a-case-of-primary-aldosteronism-caused-by-unilateral-multiple-adrenocortical-micronodules-presenting-as-muscle-cramps-at-rest-the-importance-of-functional-histopathology-for-identifying-a-culprit-lesion
#5
Atsushi Ito, Yuto Yamazaki, Hironobu Sasano, Daisuke Matsubara, Noriyoshi Fukushima, Mio Tamba, Kenichi Tabata, Kentaro Ashizawa, Akihito Takei, Masaru Koizumi, Yasunaru Sakuma, Naohiro Sata, Hisashi Oshiro
Unilateral multiple adrenocortical micronodules (UMNs) constitute a rare subset of primary aldosteronism (PA) characterized by the hypersecretion of aldosterone derived from multiple small nodules in the zona glomerulosa of the unilateral adrenal grand. This case study describes a 49-year-old man with PA and UMNs who presented with muscle cramps at rest due to hypokalemia. The patient had a 6-year history of hypertension treated with antihypertensive drugs. Imaging studies revealed bilateral adrenal nodules as large as 5 mm...
March 5, 2017: Pathology International
https://www.readbyqxmd.com/read/28213917/solid-pseudopapillary-neoplasm-expresses-inhibin-%C3%AE-and-tcf-3
#6
LETTER
Shirai Et Al, Yoko Shirai, Yasunori Enomoto, Toru Harada, Koji Asai, Shuichi Ashizuka, Masahiro Ikegami, Kei Takahashi, Norikazu Shimizu, Takashi Sekine
No abstract text is available yet for this article.
February 18, 2017: Pathology International
https://www.readbyqxmd.com/read/28208226/a-rare-case-of-tfe-related-pigmented-renal-tumor-with-overlapping-features-between-melanotic-xp11-translocation-renal-cancer-and-xp11-renal-cell-carcinoma-with-melanotic-features
#7
Leonardo Cardili, Gregório Wrublevsky Pereira, Cristiano Ribeiro Viana
In recent years, an increasing number of TFE3 rearrangement-associated tumors with melanotic features have been reported as primary neoplasm in different anatomical sites, including the kidney. Melanotic Xp11 translocation renal cancer (MXTRC) and Xp11 renal cell carcinoma with melanotic features (XRCCM) have been proposed to be main categories for pigmented lesions in the microophthalmia-associated transcription factor (MiTF/TFE3) family of renal tumors that may show variable degrees of melanocytic differentiation...
February 16, 2017: Pathology International
https://www.readbyqxmd.com/read/28208222/a-case-of-aggressive-solid-pseudopapillary-neoplasm-comparison-of-clinical-and-pathologic-features-with-non-aggressive-cases
#8
Yukihiro Watanabe, Kojun Okamoto, Katsuya Okada, Masayasu Aikawa, Isamu Koyama, Hiroshi Yamaguchi
Solid pseudopapillary neoplasms (SPNs) may have an aggressive clinical course, but clinical predictors of this condition have not been thoroughly evaluated. We performed a retrospective study of 11 cases of SPN managed in our hospital between January 2007 and April 2015. Of these 11 cases, we encountered a single case with an aggressive clinical course. Histological, immunohistochemical, and clinical features were compared to identify predictors of poor prognosis. The 11 patients comprised four women and seven men with a median age of 41 years (range, 26-58 years)...
February 16, 2017: Pathology International
https://www.readbyqxmd.com/read/28191697/composite-lymphoma-of-peripheral-t-cell-lymphoma-and-hodgkin-lymphoma-mixed-cellularity-type-pathological-and-molecular-analysis
#9
Ayako Ichikawa, Hiroaki Miyoshi, Takuji Yamauchi, Fumiko Arakawa, Riko Kawano, Hiroko Muta, Yasuo Sugita, Koichi Akashi, Koichi Ohshima
Composite lymphomas (CLs) are defined as two unrelated lymphomas occurring at the same time within the same tissue. The incidence of these tumors is low. Of all possible combinations between lymphomas, the least frequent are the ones combining peripheral T-cell lymphoma (PTCL) and Hodgkin lymphoma (HL). We recently identified five cases of CL composed of PTCL and classical HL, mixed cellularity type. We investigated histological and clinical features of these cases. Immunostaining was performed on paraffin sections...
February 13, 2017: Pathology International
https://www.readbyqxmd.com/read/28105671/primary-giant-cell-tumor-of-the-common-bile-duct-no-mutation-h3f3a-found
#10
EDITORIAL
Aurélie Beaufrère, Frédérique Larousserie, Safi Dokmak, Eric Pasmant, Janick Selves, Dominique Cazals-Hatem
No abstract text is available yet for this article.
January 20, 2017: Pathology International
https://www.readbyqxmd.com/read/28078765/a-typical-presentation-of-primary-pulmonary-epithelioid-sarcoma-misdiagnosed-as-non-small-cell-lung-cancer
#11
LETTER
Makoto Emori, Mitsuharu Tamakawa, Mitsunori Kaya, Kohichi Takada, Kazuyuki Murase, Chisa Fujita, Sayuri Sato, Ryuji Takahashi, Kanako C Hatanaka, Shintaro Sugita, Hiroshi Hirano, Toshihiko Yamashita, Tadashi Hasegawa
No abstract text is available yet for this article.
January 12, 2017: Pathology International
https://www.readbyqxmd.com/read/28066959/the-eight-year-evolution-of-an-osseous-pecoma
#12
LETTER
Georgia Karpathiou, Fabrice Guy Barral, Cyril Habougit, Vanessa Da Cruz, Fabien Forest, Olivier Collard, Michel Peoc'h
No abstract text is available yet for this article.
January 9, 2017: Pathology International
https://www.readbyqxmd.com/read/28251757/corrigendum
#13
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Pathology International
https://www.readbyqxmd.com/read/28150468/ciliated-muconodular-papillary-tumor-of-the-lung-harboring-alk-gene-rearrangement-case-report-and-review-of-the-literature
#14
REVIEW
Yan Jin, Xuxia Shen, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
Ciliated muconodular papillary tumor (CMPT) of the lung is an extremely rare peripheral tumor of the lung. The pathogenesis of CMPT is still unknown, and its nature as a benign tumor or reactive process is still open to discussion. Recent studies have identified BRAF, EGFR and AKT1 mutations in CMPT, which would support a true neoplastic process. Here for the first time, we report a case of morphologically typical CMPT harboring ALK gene rearrangement to further provide convincing evidence that CMPT is a neoplastic process rather than a reactive lesion...
March 2017: Pathology International
https://www.readbyqxmd.com/read/28145029/clinicopathological-importance-of-anterior-prostate-cancer-in-japanese-men
#15
Shun Sato, Hiroyuki Takahashi, Takahiro Kimura, Shin Egawa, Bungo Furusato, Masahiro Ikegami
Prostate cancer of transition zone origin or anterior location has been recognized as infrequent, smaller in size and indolent, whereas, our previous report showed that transition zone/anterior cancer was frequently experienced in Japanese men. The current study was conducted to show clinicopathological characteristics of transition zone/anterior cancer. A total of 201 radical prostatectomy specimens were categorized as cancer of anterior or posterior prostate where more than two thirds of the tumor existed in the specific area...
March 2017: Pathology International
https://www.readbyqxmd.com/read/28139862/the-pd-1-pd-l1-axis-may-be-aberrantly-activated-in-occupational-cholangiocarcinoma
#16
Yasunori Sato, Masahiko Kinoshita, Shigekazu Takemura, Shogo Tanaka, Genya Hamano, Shoji Nakamori, Masahiro Fujikawa, Yasuhiko Sugawara, Takatsugu Yamamoto, Akira Arimoto, Minako Yamamura, Motoko Sasaki, Kenichi Harada, Yasuni Nakanuma, Shoji Kubo
An outbreak of cholangiocarcinoma in a printing company was reported in Japan, and these cases were regarded as an occupational disease (occupational cholangiocarcinoma). This study examined the expression status of programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) in occupational cholangiocarcinoma. Immunostaining of PD-1, PD-L1, CD3, CD8, and CD163 was performed using tissue sections of occupational cholangiocarcinoma (n = 10), and the results were compared with those of control cases consisting of intrahepatic (n = 23) and extrahepatic (n = 45) cholangiocarcinoma...
March 2017: Pathology International
https://www.readbyqxmd.com/read/28110490/high-expression-of-wls-is-associated-with-lymph-node-metastasis-and-advanced-tnm-stage-in-gastric-carcinomas
#17
Wei Zhang, Hong Tao, Xiao Chen, Haruhiko Sugimura, Jiandong Wang, Ping Zhou
The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in gastric carcinoma. We hypothesized that Wls may play a role in the development and progression of gastric carcinoma. In this study, three gastric cancer cell lines MGC-803, SGC-7901, and AGS, and a set of gastric carcinoma tissue specimens were subjected to immunohistochemistry...
March 2017: Pathology International
https://www.readbyqxmd.com/read/28105693/epigenetic-regulation-of-wnt-%C3%AE-catenin-signal-associated-genes-in-gastric-neoplasia-of-the-fundic-gland-chief-cell-predominant-type
#18
Takashi Murakami, Hiroyuki Mitomi, Takashi Yao, Tsuyoshi Saito, Tomoyoshi Shibuya, Sumio Watanabe
Gastric neoplasia of the fundic gland (chief cell-predominant) type (GNCCP) is a rare variant of gastric tumor. This tumor is associated with activation of the Wnt/β-catenin signaling pathway; however, the mechanisms underlying this activation remain unknown. To elucidate potential roles of Wnt/β-catenin signal-associated gene methylation in GNCCP, we performed β-catenin immunostaining and methylation-specific polymerase chain reaction (PCR) for their associated genes, including SFRPs, APC, AXIN2, and MCC, in 26 GNCCPs [i...
March 2017: Pathology International
https://www.readbyqxmd.com/read/28102575/bcl-2-family-in-non-small-cell-lung-cancer-its-prognostic-and-therapeutic-implications
#19
Ping-Li Sun, Hironobu Sasano, Hongwen Gao
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Despite significant advances in its research of tumor biology and therapy, the prognosis for this neoplasm has still remained poor. The great majority of anticancer agents, regardless of their mechanisms of action, exert their lethal actions on cancer cells by inducing apoptosis following drug-induced cellular damage. Many reported studies have evaluated the prognostic and therapeutic implications of apoptosis in lung cancer, but their exact clinical value has remained unclear...
March 2017: Pathology International
https://www.readbyqxmd.com/read/28088838/re-evaluation-of-phenotypic-expression-in-differentiated-type-early-adenocarcinoma-of-the-stomach
#20
Masato Hayakawa, Ken Nishikura, Yoichi Ajioka, Yutaka Aoyagi, Shuji Terai
A total of 313 cases of differentiated-type early gastric adenocarcinomas, including 113 cases of small-sized carcinoma (5< × ≤10 mm) and 121 cases of microcarcinoma (0< × ≤5 mm), were examined immunohistochemically to clarify the phenotypic expressions. They were classified into four categories (gastric phenotype (G-type), intestinal phenotype, gastrointestinal phenotype, and null phenotype) by a two-step process: the phenotype based on an immunoprofile of mucin core proteins (MUCs) with CDX2 (w/...
March 2017: Pathology International
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