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Pathology International

Mitsuko Furuya, Yukio Nakatani
Birt-Hogg-Dubé (BHD) syndrome is a rare genetic disorder characterized by cutaneous fibrofolliculomas, pulmonary cysts and renal cell carcinomas. Affected individuals inherit germline mutations in the folliculin gene (FLCN). Approximately 150 pathogenic FLCN variants have been identified worldwide. Many Japanese probands of BHD syndrome were first identified by pulmonologists and/or radiologists during treatment of pneumothoraces. Lung specimens obtained through video-assisted thoracoscopic surgery (VATS) have characteristic features unique to BHD syndrome; however, pathologists often miss key findings and diagnose patients with "bullae/blebs"...
January 11, 2019: Pathology International
Fumiyoshi Kojima, Naoto Kuroda, Ibu Matsuzaki, Haruka Miyai, Isao Hara, Shin-Ichi Murata, Ondrej Hes
No abstract text is available yet for this article.
January 8, 2019: Pathology International
Akira Satou, Shogo Banno, Ichiro Hanamura, Emiko Takahashi, Taishi Takahara, Hironobu Nobata, Takayuki Katsuno, Akiyoshi Takami, Yasuhiko Ito, Ryuzo Ueda, Shigeo Nakamura, Toyonori Tsuzuki
Methotrexate (MTX) is currently used as first-line anchor drug for rheumatoid arthritis (RA). Therefore, the number of MTX-associated lymphoproliferative disorders, including Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU), has increased. Some aspects of MTX-associated EBVMCU (MTX-EBVMCU), particularly clinical behavior and treatment for RA after MTX cessation, have not been well described. Herein, we report nine cases of MTX-EBVMCU with clinical information regarding RA. Seven of nine patients showed spontaneous regression (SR) after immunosuppressive (IS) cessation...
January 7, 2019: Pathology International
Sumi Yun, Se Hyun Kim, Hwan Seong Cho, Gheeyoung Choe, Kyu Sang Lee
Intraosseous myoepithelial tumors are very rare. Due to the low incidence and diverse histologic features, accurate diagnosis is challenging, necessitating ancillary immunohistochemistry. Moreover, genetic abnormality in this tumor was not revealed until recently. Although EWSR1 translocation is involved in half of the cases of intraosseous myoepithelioma, only a few cases have indicated its counterpart gene. We herein describe a case of intraosseous myoepithelioma with a novel localization in the fourth metatarsal bone of a 36-year-old female...
January 3, 2019: Pathology International
Yuka Suzuki, Ayako Sakakibara, Kazuyuki Shimada, Satoko Shimada, Eri Ishikawa, Shigeo Nakamura, Seiichi Kato, Taishi Takahara, Naoko Asano, Akira Satou, Kei Kohno
We identified six patients with Epstein-Barr virus (EBV)-negative extranodal diffuse large B-cell lymphoma (DLBCL) and immunohistochemical expression of PD-L1 on their tumor cells by examining 283 DLBCL cases with the PD-L1 SP142 clone between 2015 and 2017. They consisted of two men and four women with a median age of 71 years, and were examined in an autopsy (n = 1) and biopsies from the adrenal gland (n = 2), skin (n = 1), pelvic cavity (n = 1), and kidney (n = 1). All showed a monomorphic population of large transformed B-cells leading to diagnoses of DLBCL with two intravascular large B-cell lymphoma (IVLBCL) and one de novo CD5+ type and were featured by an invariable immunephenotype: CD3-, CD20+, BCL-2+, and MUM1+...
January 2, 2019: Pathology International
Naoko Tsuyama, Masahiro Yokoyama, Junko Fujisaki, Masahiko Oguchi, Yasuhito Terui, Kengo Takeuchi
No abstract text is available yet for this article.
December 24, 2018: Pathology International
Sakura Tomita, Yara Yukie Kikuti, Joaquim Carreras, Naoya Nakamura
No abstract text is available yet for this article.
December 21, 2018: Pathology International
Kennichi Kakudo, Andrey Bychkov, Yanhua Bai, Yaqiong Li, Zhiyan Liu, Chan Kwon Jung
No abstract text is available yet for this article.
December 7, 2018: Pathology International
Hiroto Takeya, Takuya Shiota, Taisuke Yagi, Koji Ohnishi, Yoshifumi Baba, Yuko Miyasato, Yuki Kiyozumi, Naoya Yoshida, Motohiro Takeya, Hideo Baba, Yoshihiro Komohara
Recent findings indicate CD169-positive lymph node sinus macrophages (LySMs) in the regional lymph nodes (RLNs) play an important role in anti-cancer immunity. In the present study, we investigated the correlation between CD169 expression in RLNs and clinicopathologic factors. Higher CD169 expression in LySMs was significantly associated with longer cancer-specific survival (CSS). The density of tumor-infiltrating lymphocytes (TILs) in the cancer nest and CD169 expression on LySMs were positively associated in patients who underwent pretreatment...
December 5, 2018: Pathology International
Tadashi Yoshino, Katsuyoshi Takata, Takehiro Tanaka, Yasuharu Sato, Akira Tari, Hiroyuki Okada
The incidence of lymphoma has rapidly increased over the last 40 years in Japan, following a trend that is very similar to that of breast cancer. In particular, the relative frequency of follicular lymphoma (FL) has reached that in Western countries. Given its indolence, a "watch-and-wait" approach is often applied to FL patients. We have shown that FL is often detected in the second portion of the duodenum and has a distinct follicular dendritic cell distribution and heavy chain variable usage similar to mucosa-associated lymphoid tissue (MALT) lymphoma...
November 20, 2018: Pathology International
Teerada Daroontum, Kei Kohno, Yoko Inaguma, Akinao Okamoto, Masataka Okamoto, Yoshihiro Kimura, Masato Nagahama, Ayako Sakakibara, Akira Satou, Shigeo Nakamura
Elderly patients with Epstein-Barr virus (EBV) infection are at increased risk for developing B-cell lymphoproliferative disorder (B-LPD) due to immunosenescence. Here, we describe a case of a 75-year-old man who developed an EBV-positive (EBV+) mucocutaneous ulcer (EBVMCU) in the gingiva with spontaneous regression. Eighteen months after regression, he had a cervical lymph node enlargement that was diagnosed as EBV+ nodal polymorphous B-LPD, Ann Arbor stage IA. Clinicians decided to observe his clinical course without any treatment...
November 19, 2018: Pathology International
Yoshiki Iemura, Yosuke Yamada, Masahiro Hirata, Tatsuki R Kataoka, Sachiko Minamiguchi, Hinonori Haga
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare but occasionally fatal limbic encephalitis that may be accompanied by ovarian teratoma. Since the neuroglial tissue within the teratoma may be involved in the pathogenesis of this encephalitis, we attempted morphological and immunohistochemical characterization of the neuroglial tissue in four cases of ovarian teratoma associated with anti-NMDA receptor encephalitis and 12 control cases, i.e., six consecutive cases of immature teratoma and six cases of mature teratoma with an abundant neuronal component, focusing mainly on NMDA receptor-expressing neurons...
November 14, 2018: Pathology International
Yusuke Ishida, Masumi Tsuda, Yutaka Sawamura, Kyoko Fujii, Hiroshi Murai, Naruyoshi Horiuchi, Yasuko Orba, Hirofumi Sawa, William W Hall, Kazuo Nagashima, Shinya Tanaka
A 24 year-old female presented with a mass lesion in the right temporal lobe. This case was difficult to diagnose using histological and immunological methods and therefore molecular analyses were applied to provide a definitive diagnosis. The tumor was well-demarcated, partially cystic, and irregularly-enhanced on gadolinium-enhanced T1-weighted magnetic resonance images. Pathologically, a large part of the tumor consisted of cells with fine cytoplasmic processes on a myxoid and mucinous background. Cells formed a microcystic structure around the mucinous tissue...
November 12, 2018: Pathology International
Anna Caterina Milanetto, Liço Valbona, Rita Alaggio, Giada Munari, Sergio Pedrazzoli, Matteo Fassan, Claudio Pasquali
No abstract text is available yet for this article.
November 12, 2018: Pathology International
Pi-Han Liao, Shih-Cheng Chou, Wan-Ting Huang, Ying-Zhen Su, Ming-Chung Wang, Shih-Sung Chuang
No abstract text is available yet for this article.
November 6, 2018: Pathology International
Hiromi Tsuji, Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Takashi Hiroshima, Yasushi Sakamaki, Akira Miyauchi, Masahiko Tsujimoto
The cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare morphologic entity in which metastasis rarely occurs. Until now, only three cases of metastasis by CMV-PTC have been reported. We present a rare sporadic case of CMV-PTC with multiple lung metastases in a 28-year-old female, 3 years after total thyroidectomy. The lung tumor was not encapsulated but well-circumscribed and showed a mixture of cribriform, papillary, and solid patterns of growth with necrosis. The tall columnar carcinoma cells did not display the typical nuclear features of PTC...
October 30, 2018: Pathology International
(no author information available yet)
No abstract text is available yet for this article.
December 2018: Pathology International
(no author information available yet)
No abstract text is available yet for this article.
December 2018: Pathology International
Masahide Fukuda, Hirohito Ishigaki, Hiromitsu Ban, Mitsushige Sugimoto, Eri Tanaka, Junpei Yonemaru, Shinobu Kuroe, Tomo Namura, Akiko Matsubara, Suzuko Moritani, Kazunari Murakami, Akira Andoh, Ryoji Kushima
A fundic gland polyp (FGP) is a common gastric polyp. Intraepithelial neoplasia in FGPs, referred to as FGP with dysplasia, is often seen in patients with familial adenomatous polyposis (FAP). In sporadic FGPs, low-grade dysplasia (LGD) is rare, and high-grade dysplasia (HGD) or carcinoma arising from sporadic FGPs is extremely rare. Because of this rarity, the prognosis and appropriate management of these lesions have not been clarified. In the present case, a sporadic FGP with LGD did not develop into invasive carcinoma, but contained foci of HGD 14 years after diagnosis...
December 2018: Pathology International
Christopher A French
NUT carcinoma (NC) is a rare, aggressive subtype of squamous cell carcinoma defined by rearrangement of the NUTM1 (aka NUT) gene. NC is driven by NUT-fusion oncoproteins resulting from chromosomal translocation, most commonly BRD4-NUT. This is a nearly uniformly lethal cancer affecting patients of all ages, but predominantly teens and young adults. The cell of origin is unknown, but NC most commonly arises within the thorax and head and neck. NC typically consists of sheets of monomorphic primitive round cells that can exhibit focal abrupt squamous differentiation...
November 2018: Pathology International
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