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Pathology International

Toshiki Hyodo, Maki Kanzawa, Shigeo Hara, Kosuke Takahashi, Satoshi Ogawa, Junya Furukawa, Masato Fujisawa, Anna Kobayashi, Naoto Kuroda, Tomoo Itoh
Renal cell carcinoma (RCC) occasionally has sarcomatoid differentiation and rarely contains heterologous components. We report a case of chromophobe RCC with sarcomatoid differentiation that had various heterologous components including a unique lipomatous area. The patient was an 83-year-old woman with a palpable mass in the left lower abdomen. Grossly, the tumor was 14 cm in diameter and had yellowish-to-whitish color with focal necrosis and hemorrhage. Histologically, the tumor was composed of an eosinophilic subtype of chromophobe RCC with sarcomatoid differentiation including mainly chondrosarcoma, some osteosarcoma and a lipomatous area...
July 17, 2018: Pathology International
Junichi Kiyasu, Fumiko Arakawa, Shojiro Haji, Yoshimichi Tachikawa, Mariko Tsuda, Yasuhiro Tsukamoto, Motohiko Ikeda, Hiroki Muta, Takamitsu Matsushima, Hiroaki Miyoshi, Motoaki Shiratsuchi, Yoshihiro Ogawa, Kouichi Ohshima, Yuji Yufu
Although gamma heavy chain disease (γ-HCD) lesions occasionally morphologically resemble angioimmunoblastic T-cell lymphoma (AITL), no association has been described in detail due to the rarity of the disease. In this report, we present a rare manifestation of methotrexate (MTX)-associated lymphoproliferative disorders (LPDs) with AITL-like features accompanied by γ-HCD in a 75-year-old man with rheumatoid arthritis (RA). A biopsy specimen was evaluated using immunohistochemistry, clonal analyses of immunoglobulin VH and T-cell receptor γ gene rearrangements by polymerase chain reaction, and Sanger sequencing for confirmation of the structure of deleted γ-HCD clones...
July 10, 2018: Pathology International
Marini Stephanie, Rie Irie, Kengo Sasaki, Yoshihiro Hirata, Soichi Narumoto, Akinari Fukuda, Seisuke Sakamoto, Katsuhiro Arai, Takako Yoshioka, Mureo Kasahara
No abstract text is available yet for this article.
June 22, 2018: Pathology International
Vinicius Carrera Souza, Christiana de Freitas Vinhas, Diego Miguel, Daniel Abensur Athanazio, Kiril Trpkov
No abstract text is available yet for this article.
June 22, 2018: Pathology International
Jun Miyauchi, Masaharu Ogura, Michio Sato, Junichi Matsui
Esophageal carcinosarcoma is a rare neoplasm with components of squamous cell carcinoma and sarcomatous spindle cell stroma. The latter may show overt mesenchymal differentiation but is thought to be derived from carcinoma cells in most cases. Here, we report a case of esophageal carcinosarcoma that appeared to be comprised of different origins of epithelial and mesenchymal tumor cells. The sarcomatous component formed an intralumial pedunculated large mass lesion that consisted of pleomorphic atypical histiocyte-like cells...
June 22, 2018: Pathology International
Masakazu Fujimoto, Yusuke Yamashita, Hironori Haga, Takashi Akasaka, Yoshifumi Iwahashi, Kenji Warigaya, Fumiyoshi Kojima, Yuya Hama, Shinobu Tamura, Takashi Sonoki, Shin-Ichi Murata
No abstract text is available yet for this article.
June 19, 2018: Pathology International
Masato Komatsu, Tetsuya Hashimoto, Keisuke Hanioka, Tomoo Itoh, Takanori Hirose
No abstract text is available yet for this article.
June 19, 2018: Pathology International
Aya Sasaki, Hitoshi Abe, Satsuki Mochizuki, Masayuki Shimoda, Yasunori Okada
ADAM28 (a disintegrin and metalloproteinase 28) is abundantly expressed by carcinoma cells in the human breast and non-small cell lung carcinomas, and plays a role in carcinoma cell growth and metastasis. Although Src is an inducer of ADAM28 gene expression through the PI3K/AKT/mTOR and MEK/ERK pathways, direct transcriptional regulators for ADAM28 gene expression remain unknown. In this study, we performed the luciferase reporter assay and found that SOX4 (SRY-related HMG-box 4), an inducer of epithelial-mesenchymal transition (EMT), is a transcriptional activator for the ADAM28 gene...
June 7, 2018: Pathology International
Kana Matsumoto, Naoko Udaka, Hisashi Hasumi, Noboru Nakaigawa, Yoji Nagashima, Reiko Tanaka, Ikuma Kato, Masahiro Yao, Mitsuko Furuya
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder characterized by cutaneous and uterine leiomyomatosis with RCC. This disorder is caused by a germline mutation in the fumarate hydratase (FH) gene, which encodes an important enzyme of the tricarboxylic acid (TCA) cycle. This mutation distinguishes HLRCC from sporadic RCCs. Herein, we investigated a case of HLRCC in a 32-year-old man who underwent nephrectomy for treatment of a solid-cystic tumor in the left kidney. Histopathology demonstrated a variegated architecture of papillary, tubulocystic and cribriform patterns composed of high-grade tumor cells with enlarged nuclei and eosinophilic nucleoli...
May 24, 2018: Pathology International
Rin Yamada, Akiko Tonooka, Shin-Ichiro Horiguchi, Toru Motoi, Horio Hirotoshi, Tsunekazu Hishima
Pulmonary hamartoma (PH) is the most common benign lung tumor, comprising various amounts of mescenchymal components with entrapped epithelial components. We describe an unusual case of PH in the left lower lung lobe of a 60-year-old female. The tumor was 9 × 9 mm in size, light brown, weakly glistening, and microscopically found to be composed of well-developed epithelial and mesenchymal components without atypia. Both components were intermingled but without apparent transition. Epithelial components were occupied by predominant bronchial mucous glands...
May 16, 2018: Pathology International
Yusuke Okabayashi, Go Kanzaki, Nobuo Tsuboi, Kotaro Haruhara, Kentaro Koike, Masahiro Ikegami, Akira Shimizu, Takashi Yokoo
No abstract text is available yet for this article.
May 10, 2018: Pathology International
Atsushi Miyamoto, Amita Sharma, Michiya Nishino, Mari Mino-Kenudson, Osamu Matsubara, Eugene Jerome Mark
Acute exacerbation is uncommonly diagnosed in patients with nonspecific interstitial pneumonia (NSIP) and its pathologic features have received relatively little attention compared to idiopathic pulmonary fibrosis. We retrospectively studied 14 consecutive cases of histopathologically proven NSIP by surgical lung biopsy. The diagnosis of acute exacerbation was confirmed clinically. We analyzed whether four reported pathologic features, including organizing pneumonia lesion, alveolar hemorrhage, many fibroblastic foci, and focal hyaline membranes were present and suggestive of acute exacerbation of NSIP or not...
May 3, 2018: Pathology International
Shu Kato, Motoi Yanazaki, Kino Hayashi, Fumiko Satoh, Ichiro Isobe, Yutaka Tsutsumi
Five autopsy cases of fulminant group A streptococcal infection without gangrene in the extremities are presented. Clinical course of the fulminant illness was short (2-4 days). One pathological autopsy case was aged (86-years-old), and hemorrhagic cystitis was observed. The other four forensic autopsy cases were young (24-38 years-old) with the mean age of 32, and the primary infective lesions were located in the postpartum endometrium, tonsil and bronchus (2 cases). Systemic coccal dissemination with poor neutrophilic reaction was seen in two of five cases...
May 3, 2018: Pathology International
Yuko Kitawaki, Fumiyoshi Fujishima, Shinji Taniuchi, Ryoko Saito, Yasuhiro Nakamura, Ryoko Sato, Yayoi Aoyama, Yoshiaki Onodera, Naoko Inoshita, Yasushi Matsuda, Mika Watanabe, Hironobu Sasano
Both glandular papilloma (GP) and sclerosing pneumocytoma (SP) are rare tumors in the lung. We herein report an extremely rare case of coexistence of these two uncommon tumors. The patient was a 40-year-old Japanese woman with no chief complaint. A solitary nodule of the lung was detected using chest computed tomography. The transbronchial biopsy revealed that the tumor histologically corresponded to GP. The patient subsequently underwent partial resection of the right upper lobe. Histological examination of the resected specimens further revealed that the mass contained two different and independent elements and displayed typically histological features of GP and SP...
April 25, 2018: Pathology International
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Pathology International
Mari Fujii, Yasuyoshi Mizutani, Takahiko Sakuma, Kouichiro Tagami, Kiichiro Okamoto, Yasushi Kuno, Michihiko Harada, Koichi Kubouchi, Yutaka Tsutsumi
Granulomatous mastitis (GM) is a rare inflammatory disease of the post-lactation breast, clinically mimicking breast cancer. GM is microscopically characterized by formation of epithelioid granulomas and abscess (suppurative granulomas) with lipid droplet-centered inflammation. Corynebacterium kroppenstedtii (Ck) is known as a causative bacterium of GM, and identification of Ck infection within the lesion should thus be essential for confirming the diagnosis. In the present study, we analyzed formalin-fixed, paraffin-embedded (FFPE) biopsy specimens of a total of 18 GM lesions with immunostaining and real-time PCR for Ck genome...
July 2018: Pathology International
Kennichi Kakudo, Adel K El-Naggar, Steven P Hodak, Elham Khanafshar, Yuri E Nikiforov, Vania Nosé, Lester D R Thompson
No abstract text is available yet for this article.
June 2018: Pathology International
Hiroshi Yokozaki, Yu-Ichiro Koma, Manabu Shigeoka, Mari Nishio
We review the significance of cancer-stromal interactions (CSIs) in the development, morphogenesis and progression of human gastric and esophageal cancer based on the data obtained from co-culture experiments. Orthotopic fibroblasts in the gastric cancer stroma not only promoted their growth by cancer cells but were also responsible for the mobility, morphogenesis and epithelial-to-mesenchymal transition (EMT) of the cancer cells through CSI. Bone marrow-derived mesenchymal stem cells could be part of the origin of cancer-associated fibroblasts (CAFs) of the gastric cancer providing an advantageous microenvironment for the restoration of cancer stem cells with the induction of the EMT...
June 2018: Pathology International
Misa Song, Hayato Kimura, Hideharu Ogiyama, Takayuki Nishigami
Multiple system atrophy (MSA) is a spinocerebellar degenerative disease characterized by cerebellar ataxia, parkinsonism, and autonomic failure. A 75-year-old woman who had suffered from dysphagia and dysuria under a diagnosis of probable MSA with predominant cerebellar ataxia underwent autopsy. Eosinophilia was seen extensively in the muscle layer of the esophagus and urinary bladder. Eosinophilic infiltration to the esophagus was localized in the smooth muscle layer and could be considered as "eosinophilic esophageal myositis" identified in patients with nutcracker esophagus and jackhammer esophagus...
June 2018: Pathology International
Yoshie Obata, Yoriko Yamashita, Koji Takahashi, Kouki Yasuda, Tomomi Kato, Masanori Yasuda, Aya Naiki-Ito, Satoru Takahashi, Tetsuro Nagasaka
Endometrial clear-cell carcinoma (ECC) is relatively rare. The expression of diagnostic markers in this disease is similar to that of clear-cell carcinoma, but the molecular carcinogenic events and therapeutic targets are mostly unknown. MET gene amplification has been reported in various cancers, including ovarian clear-cell carcinomas; however, the MET gene status has not previously been examined in ECC. We performed real-time quantitative PCR (QPCR) and fluorescence in situ hybridization (FISH) to analyze the MET gene statuses of 12 ECC cases...
June 2018: Pathology International
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