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Pathology International

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https://www.readbyqxmd.com/read/28422378/cellular-retinoic-acid-bioavailability-in-various-pathologies-and-its-therapeutic-implication
#1
REVIEW
Makoto Osanai
Retinoic acid (RA), an active metabolite of vitamin A, is a critical signaling molecule in various cell types. We found that RA depletion caused by expression of the RA-metabolizing enzyme CYP26A1 promotes carcinogenesis, implicating CYP26A1 as a candidate oncogene. Several studies of CYP26s have suggested that the biological effect of RA on target cells is primarily determined by "cellular RA bioavailability", which is defined as the RA level in an individual cell, rather than by the serum concentration of RA...
April 19, 2017: Pathology International
https://www.readbyqxmd.com/read/28419636/a-case-of-solitary-pulmonary-capillary-hemangioma-indicating-true-gross-appearance
#2
LETTER
Hirotsugu Hashimoto, Masahiro Yanagiya, Yoshio Suzuki, Masashi Kusakabe, Genki Usui, Jun Matsumoto, Hajime Horiuchi
No abstract text is available yet for this article.
April 17, 2017: Pathology International
https://www.readbyqxmd.com/read/28393435/pathogenetic-significance-and-possibility-as-a-therapeutic-target-of-platelet-derived-growth-factor
#3
REVIEW
Yoko Ishii, Takeru Hamashima, Seiji Yamamoto, Masakiyo Sasahara
Platelet-derived growth factor (PDGF) is one of the major mitogens and chemoattractants for mesenchymal and glial cells. Nowadays, the expression of PDGFs are recognized widely in our body, and emerging data indicate the relevance of PDGFs in the homeostatic control of systemic connective tissue as well as parenchymal cells such as neurons. Aberrant PDGF signal is primarily tumorigenic, and also regulates tumor microenvironments. The roles of the PDGF signal in tumorigenesis are diverse depending on the type of cancer, and anti-PDGF therapy needs to be carefully designed based on the information of each tumor cell type and the surrounding microenvironment...
April 10, 2017: Pathology International
https://www.readbyqxmd.com/read/28370778/clinical-and-pathological-significance-of-myeloid-differentiation-factor-88-expression-in-human-hepatocellular-carcinoma-tissues
#4
Keiichi Kinowaki, Yurie Soejima, Arisa Kumagai, Fukuo Kondo, Keiji Sano, Takeshi Fujii, Masanobu Kitagawa, Toshio Fukusato
The innate immune system, which includes toll-like receptor (TLR) signaling, plays an important role in inflammation and oncogenesis. Although TLR common adaptor myeloid differentiation factor 88 (MyD88) is known to have multiple effects on carcinogenesis, the role of MyD88 in hepatocarcinogenesis remains unknown. In this study, MyD88 expression was examined in 105 samples of human hepatocellular carcinoma (HCC) tissue by immunohistochemistry, Western blot, and quantitative reverse-transcriptase polymerase chain reaction methods...
April 3, 2017: Pathology International
https://www.readbyqxmd.com/read/28371144/laminar-crystal-deposition-in-large-vessels-in-a-patient-with-crystalglobulinemia
#5
Yukako Shintani-Domoto, Aya Shinozaki-Ushiku, Hidemi Okuma, Mineo Kurokawa, Masashi Fukayama
Crystalglobulinemia is an extremely rare complication of monoclonal gammopathy and is characterized by crystal thrombi within systemic organs. We herein report the first described case of crystalglobulinemia accompanied by laminar crystal deposition in the large vessels. A 44-year-old man presented with a history of numbness, pain, and swelling of the left leg in addition to visual impairment. Renal and skin biopsies revealed crystal thrombi within the capillary lumens. The patient was finally diagnosed with crystalglobulinemia associated with multiple myeloma...
March 31, 2017: Pathology International
https://www.readbyqxmd.com/read/28370814/l-type-amino-acid-transporter-1-expression-in-esophageal-carcinogenesis-according-to-who-and-japanese-classifications-of-intraepithelial-neoplasia
#6
Hirotsugu Hashimoto, Atsushi Kurata, Hiroyuki Kikuchi, Yoshio Masuda, Koji Fujita, Rikiya Okuyama, Shigeru Inoue, Hajime Horiuchi, Masahiko Kuroda
L-type amino acid transporter 1 (LAT1) has an essential role in cell proliferation especially in neoplasms. Although immunohistochemical expression of LAT1 has been investigated in invasive esophageal carcinoma, its expression in intraepithelial neoplasia (IEN) has not been reported. Further, classification of esophageal IEN is currently different between the World Health Organization (WHO) and Japanese criteria. Therefore, in this study, immunohistochemical expressions of LAT1 along with Ki-67 were analyzed in 66 esophageal samples of endoscopic submucosal dissection...
March 29, 2017: Pathology International
https://www.readbyqxmd.com/read/28337832/retroperitoneal-dedifferentiated-liposarcoma-with-huge-cystic-degeneration-a-case-report
#7
Kazuyoshi Uchihashi, Atsuji Matsuyama, Eisuke Shiba, Yoshizo Kimura, Toshiro Ogata, Kei Yabuki, Hiroshi Harada, Chisachi Kubo, Yojiro Tsuda, Mao Jotatsu, Masanori Hisaoka
Prominent cyst formation is an unusual feature of liposarcoma. We report here a case of dedifferentiated liposarcoma with huge cystic change without preoperative chemo- or radiation therapy. The lesion arose in the retroperitoneum juxtaposed to the right kidney of a 67-year-old woman. She underwent a surgical removal of the retroperitoneal cyst. The cystic tumor contained 1600 mL of old bloody fluid, and its wall was composed of edematous, inflamed or sclerosing fibrous tissue with fatty tissue containing abundant atypical stromal cells, which were immunohistochemically positive for MDM2 and CDK4, and demonstrated MDM2 gene amplification by fluorescence in situ hybridization...
March 23, 2017: Pathology International
https://www.readbyqxmd.com/read/28271635/a-case-of-ovarian-steroid-cell-tumor-with-bizarre-nuclear-atypia-and-ctnnb1-mutation
#8
Masaki Suzuki, Jun Matsushima, Takuya Yazawa, Satoshi Ota, Takako Kiyokawa, Hiroki Sonehara, Shinsuke Hanawa, Akira Mitsuhashi, Makio Shozu, Yukio Nakatani
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28271590/bizarre-stromal-cells-mimicking-malignancy-in-chondro-osseous-respiratory-epithelial-adenomatoid-hamartoma
#9
LETTER
Kyriakos Chatzopoulos, Marios Stavrakas, Prodromos Hytiroglou, Stefanos Triaridis
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28271585/renal-angiomyolipoma-with-para-aortic-lymph-node-involvement
#10
LETTER
Koto Kon-Nanjo, Youichiro Baba, Yuko Yoshio, Ryuichi Suzuki, Tomio Araki, Tetsuya Murata
No abstract text is available yet for this article.
March 8, 2017: Pathology International
https://www.readbyqxmd.com/read/28370983/corrigendum
#11
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Pathology International
https://www.readbyqxmd.com/read/28261941/plaque-formation-and-the-intraneuronal-accumulation-of-%C3%AE-amyloid-in-alzheimer-s-disease
#12
REVIEW
Reisuke H Takahashi, Toshitaka Nagao, Gunnar K Gouras
Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-prone forms of Aβ. The findings of familial AD mutations in the APP gene suggest that Aβ plays a central role in the pathophysiology of AD...
April 2017: Pathology International
https://www.readbyqxmd.com/read/28261922/a-case-of-primary-aldosteronism-caused-by-unilateral-multiple-adrenocortical-micronodules-presenting-as-muscle-cramps-at-rest-the-importance-of-functional-histopathology-for-identifying-a-culprit-lesion
#13
Atsushi Ito, Yuto Yamazaki, Hironobu Sasano, Daisuke Matsubara, Noriyoshi Fukushima, Mio Tamba, Kenichi Tabata, Kentaro Ashizawa, Akihito Takei, Masaru Koizumi, Yasunaru Sakuma, Naohiro Sata, Hisashi Oshiro
Unilateral multiple adrenocortical micronodules (UMNs) constitute a rare subset of primary aldosteronism (PA) characterized by the hypersecretion of aldosterone derived from multiple small nodules in the zona glomerulosa of the unilateral adrenal grand. This case study describes a 49-year-old man with PA and UMNs who presented with muscle cramps at rest due to hypokalemia. The patient had a 6-year history of hypertension treated with antihypertensive drugs. Imaging studies revealed bilateral adrenal nodules as large as 5 mm...
April 2017: Pathology International
https://www.readbyqxmd.com/read/28213917/solid-pseudopapillary-neoplasm-expresses-inhibin-%C3%AE-and-tcf-3
#14
LETTER
Shirai Et Al, Yoko Shirai, Yasunori Enomoto, Toru Harada, Koji Asai, Shuichi Ashizuka, Masahiro Ikegami, Kei Takahashi, Norikazu Shimizu, Takashi Sekine
No abstract text is available yet for this article.
April 2017: Pathology International
https://www.readbyqxmd.com/read/28208226/a-rare-case-of-tfe-related-pigmented-renal-tumor-with-overlapping-features-between-melanotic-xp11-translocation-renal-cancer-and-xp11-renal-cell-carcinoma-with-melanotic-features
#15
Leonardo Cardili, Gregório Wrublevsky Pereira, Cristiano Ribeiro Viana
In recent years, an increasing number of TFE3 rearrangement-associated tumors with melanotic features have been reported as primary neoplasm in different anatomical sites, including the kidney. Melanotic Xp11 translocation renal cancer (MXTRC) and Xp11 renal cell carcinoma with melanotic features (XRCCM) have been proposed to be main categories for pigmented lesions in the microophthalmia-associated transcription factor (MiTF/TFE3) family of renal tumors that may show variable degrees of melanocytic differentiation...
April 2017: Pathology International
https://www.readbyqxmd.com/read/28208222/a-case-of-aggressive-solid-pseudopapillary-neoplasm-comparison-of-clinical-and-pathologic-features-with-non-aggressive-cases
#16
Yukihiro Watanabe, Kojun Okamoto, Katsuya Okada, Masayasu Aikawa, Isamu Koyama, Hiroshi Yamaguchi
Solid pseudopapillary neoplasms (SPNs) may have an aggressive clinical course, but clinical predictors of this condition have not been thoroughly evaluated. We performed a retrospective study of 11 cases of SPN managed in our hospital between January 2007 and April 2015. Of these 11 cases, we encountered a single case with an aggressive clinical course. Histological, immunohistochemical, and clinical features were compared to identify predictors of poor prognosis. The 11 patients comprised four women and seven men with a median age of 41 years (range, 26-58 years)...
April 2017: Pathology International
https://www.readbyqxmd.com/read/28191697/composite-lymphoma-of-peripheral-t-cell-lymphoma-and-hodgkin-lymphoma-mixed-cellularity-type-pathological-and-molecular-analysis
#17
Ayako Ichikawa, Hiroaki Miyoshi, Takuji Yamauchi, Fumiko Arakawa, Riko Kawano, Hiroko Muta, Yasuo Sugita, Koichi Akashi, Koichi Ohshima
Composite lymphomas (CLs) are defined as two unrelated lymphomas occurring at the same time within the same tissue. The incidence of these tumors is low. Of all possible combinations between lymphomas, the least frequent are the ones combining peripheral T-cell lymphoma (PTCL) and Hodgkin lymphoma (HL). We recently identified five cases of CL composed of PTCL and classical HL, mixed cellularity type. We investigated histological and clinical features of these cases. Immunostaining was performed on paraffin sections...
April 2017: Pathology International
https://www.readbyqxmd.com/read/28105671/primary-giant-cell-tumor-of-the-common-bile-duct-no-mutation-h3f3a-found
#18
LETTER
Aurélie Beaufrère, Frédérique Larousserie, Safi Dokmak, Eric Pasmant, Janick Selves, Dominique Cazals-Hatem
No abstract text is available yet for this article.
April 2017: Pathology International
https://www.readbyqxmd.com/read/28078765/a-typical-presentation-of-primary-pulmonary-epithelioid-sarcoma-misdiagnosed-as-non-small-cell-lung-cancer
#19
LETTER
Makoto Emori, Mitsuharu Tamakawa, Mitsunori Kaya, Kohichi Takada, Kazuyuki Murase, Chisa Fujita, Sayuri Sato, Ryuji Takahashi, Kanako C Hatanaka, Shintaro Sugita, Hiroshi Hirano, Toshihiko Yamashita, Tadashi Hasegawa
No abstract text is available yet for this article.
April 2017: Pathology International
https://www.readbyqxmd.com/read/28251757/corrigendum
#20
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Pathology International
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