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Pathology International

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https://www.readbyqxmd.com/read/27891686/implementation-of-a-real-time-reference-and-calibration-grid-platform-for-improved-screening-mapping-in-pap-test-slides
#1
Evangelos Tsiambas, Christos Riziotis
Cervical cancer screening based on the Papanicolaou (Pap) test is a widely applied but not always efficient practice for detecting Human Papillomavirus (HPV) mediated lesions, partially due to a non-systematic and inadequate screening process. Our aim was to introduce an inexpensive easy-to-use direct screening platform for improved detection of abnormal cells indicative of underlying cervical neoplasia as well as persisting HPV infection. By employing a novel, efficient technique of laser-based micromachining, we achieved the fabrication of spatial grids on commercially available coverslips allowing visual segmentation of the slide for efficient screening...
November 27, 2016: Pathology International
https://www.readbyqxmd.com/read/27886416/a-case-of-solitary-well-differentiated-papillary-mesothelioma-with-invasive-foci-in-the-pleura
#2
Shigeki Shimizu, Hyung-Eun Yoon, Norimasa Ito, Taisuke Tsuji, Yasunobu Funakoshi, Tomoki Utsumi, Masahiro Sakaguchi, Toru Tsujimura, Takahiko Kasai, Kenzo Hiroshima, Akihide Matsumura
Well-differentiated papillary mesothelioma (WDPM) is a rare, distinct tumor consisting of mesothelial cells with a papillary architecture, bland cytological features, and a tendency toward superficial spread without invasion. Rare cases with superficial invasion are termed WDPM with invasive foci. We report a case of solitary WDPM with invasive foci in the pleura. A 61-year-old woman presented with a lung adenocarcinoma. A small papillary lesion measuring 29 × 10 × 8 mm was incidentally found in the parietal pleura during a lobectomy for the lung adenocarcinoma...
November 25, 2016: Pathology International
https://www.readbyqxmd.com/read/27879024/a-newly-emerged-osteosarcomatous-dedifferentiation-of-liposarcoma-in-lung-metastasis-a-potential-diagnostic-pitfall
#3
LETTER
Jian Li, Noriko Motoi, Hiroaki Kanda, Yoshiya Sugiura, Hiroko Nagano, Junji Yonese, Sakae Okumura, Seiichi Matsumoto, Rikuo Machinami, Yuichi Ishikawa
No abstract text is available yet for this article.
November 23, 2016: Pathology International
https://www.readbyqxmd.com/read/27868293/clinical-features-of-diffuse-large-b-cell-lymphoma-with-polyploidy
#4
Joji Shimono, Hiroaki Miyoshi, Masao Seto, Takanori Teshima, Koichi Ohshima
Polyploidy, defined as more than two sets of homologous chromosomes, is found in a variety of malignant tumors and is thought to be related to disease pathogenesis. However, there have been no studies that have investigated polyploidy in diffuse large B-cell lymphoma (DLBCL). Here we reviewed clinicopathological features of 16 cases of DLBCL with polypoidy, which was defined as DLBCL with either near-tetraploid or greater number of chromosomes as detected by the G-band method. The frequency of polyploid DLBCL was 2...
November 21, 2016: Pathology International
https://www.readbyqxmd.com/read/27714899/ulcerated-plaque-of-coronary-artery-insights-from-ex-vivo-images-of-optical-frequency-domain-imaging-and-histopathology
#5
Akiko Fujino, Hiroyuki Hao, Rika Kawakami, Yasu-Aki Tsuchida, Takahiro Imanaka, Ten Saita, Kenichi Fujii, Masaharu Ishihara, Seiichi Hirota
No abstract text is available yet for this article.
October 7, 2016: Pathology International
https://www.readbyqxmd.com/read/27699925/gastric-heterotopic-pancreas-with-low-grade-dysplasia-of-the-ducts
#6
Ceren Boyaci, Esra Pasaoglu, Oguzhan Okcu, Nevra Dursun
No abstract text is available yet for this article.
October 3, 2016: Pathology International
https://www.readbyqxmd.com/read/27678343/quantitative-pcr-for-htlv-1-provirus-in-adult-t-cell-leukemia-lymphoma-using-paraffin-tumor-sections
#7
Junki Kato, Ayako Masaki, Keiichiro Fujii, Hisashi Takino, Takayuki Murase, Kentaro Yonekura, Atae Utsunomiya, Takashi Ishida, Shinsuke Iida, Hiroshi Inagaki
Detection of HTLV-1 provirus using paraffin tumor sections may assist the diagnosis of adult T-cell leukemia/lymphoma (ATLL). For the detection, non-quantitative PCR assay has been reported, but its usefulness and limitations remain unclear. To our knowledge, quantitative PCR assay using paraffin tumor sections has not been reported. Using paraffin sections from ATLLs and non-ATLL T-cell lymphomas, we first performed non-quantitative PCR for HTLV-1 provirus. Next, we determined tumor ratios and carried out quantitative PCR to obtain provirus copy numbers...
September 27, 2016: Pathology International
https://www.readbyqxmd.com/read/27671927/notch-signaling-in-oral-squamous-neoplasia
#8
Kei Sakamoto
Notch signaling is involved in cell-cell communication. It is an evolutionarily ancient mechanism and plays a fundamental role in development. The typical function of Notch signaling is the regulation of cell fate segregation at asymmetric division; however, a role in tumorigenesis has also been suggested. Inactivating mutations of NOTCH1 are present in about 10 % of cases of squamous cell carcinoma of the skin, oral cavity, esophagus, and lung, rendering it one of the most frequently mutated genes in squamous cell carcinoma...
September 26, 2016: Pathology International
https://www.readbyqxmd.com/read/27671838/ciliated-muconodular-papillary-tumor-of-the-lung-a-report-of-five-cases
#9
Tetsuo Kon, Youichiro Baba, Ichiro Fukai, Gen Watanabe, Tomoko Uchiyama, Tetsuya Murata
Ciliated muconodular papillary tumor (CMPT) of the lung is a newly defined and extremely rare tumor characterized by a papillary growth pattern, consisting of ciliated columnar cells, mucous cells, and basal cells with abundant mucin production. Tumor definitions and clinicopathological features continue to be debated. Herein, we report five surgical cases of CMPT to characterize its radiographic, gross, and microscopic features. The five cases involved three male patients aged 80, 67, and 66 years, and two female patients aged 73 and 70 years...
September 26, 2016: Pathology International
https://www.readbyqxmd.com/read/27663997/bile-duct-adenoma-in-patient-with-chronic-hepatitis-c-as-a-benign-neoplasm-by-pathological-and-imaging-studies
#10
Soo Ki Kim, Soo Ryang Kim, Susumu Imoto, Chi Wan Kim, Toshiyuki Matsuoka, Osamu Nakashima, Motoko Sasaki, Tsutomu Kumabe, Masatoshi Kudo, Toshio Fukusato, Fukuo Kondo
No abstract text is available yet for this article.
September 23, 2016: Pathology International
https://www.readbyqxmd.com/read/27910266/subject-index
#11
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Pathology International
https://www.readbyqxmd.com/read/27910265/acknowledgments
#12
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Pathology International
https://www.readbyqxmd.com/read/27910264/vaccination-against-h9n2-avian-influenza-virus-reduces-bronchus-associated-lymphoid-tissue-formation-in-cynomolgus-macaques-after-intranasal-virus-challenge-infection
#13
Misako Nakayama, Hiroichi Ozaki, Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Chun-Ho Park, Hideaki Tsuchiya, Hiroshi Kida, Kazumasa Ogasawara
H9N2 avian influenza virus causes sporadic human infection. Since humans do not possess acquired immunity specific to this virus, we examined the pathogenicity of an H9N2 virus isolated from a human and then analyzed protective effects of a vaccine in cynomolgus macaques. After intranasal challenge with A/Hong Kong/1073/1999 (H9N2) (HK1073) isolated from a human patient, viruses were isolated from nasal and tracheal swabs in unvaccinated macaques with mild fever and body weight loss. A formalin-inactivated H9N2 whole particle vaccine derived from our virus library was subcutaneously inoculated to macaques...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27910263/author-index
#14
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Pathology International
https://www.readbyqxmd.com/read/27873390/analysis-of-multiple-primary-cancer-autopsy-cases-associated-with-breast-cancer-2002-2010
#15
Yukiko Shibahara, Yumi Sugawara, Yasuhiro Miki, Shuko Hata, Hiroaki Takahashi, Yasuhiro Nakamura, Takashi Suzuki, Noriaki Ohuchi, Ichiro Tsuji, Hironobu Sasano
Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 2010 were analyzed for multiple primary cancer (MPC). Female MPC cases (4222 cases) were selected. We investigated the cancer incidence observed in breast cancer associated MPC. The Chi-squared test was used for analysis...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27862693/gli1-a-master-regulator-of-the-hallmark-of-pancreatic-cancer
#16
REVIEW
Kenji Kasai
Hedgehog signaling is highly conserved across species and governs proper embryonic development. Germline gene mutations that reduce this signaling activity cause a variety of developmental abnormalities such as holoprosencephaly, while those that enhance Hedgehog signaling activity induce a tumor-predisposition condition Nevoid basal cell carcinoma syndrome. Furthermore, dysregulated activation of Hedgehog signaling has been recognized in various sporadic malignancies, including pancreatic adenocarcinoma. Pancreatic adenocarcinoma develops through a multistep carcinogenesis starting with oncogenic mutation of the KRAS gene...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27862661/well-differentiated-neuroendocrine-tumor-of-the-breast-with-extensive-lymphatic-and-vascular-infiltration
#17
LETTER
Tokiko Nakai, Tomonori Kawasaki, Takashi Tada, Motoo Ishida, Akari Iwakoshi, Atsushi Enomoto, Satoshi Okuda, Masahide Takahashi, Jun-Ichi Ambo, Tamotsu Sugai, Chiho Ohbayashi, Shu Ichihara
No abstract text is available yet for this article.
December 2016: Pathology International
https://www.readbyqxmd.com/read/27862649/positivity-rate-of-ttf-1-on-immunohistochemistry-in-pancreatic-neuroendocrine-tumors
#18
LETTER
Jayson Wang, Pritesh Trivedi, Mona El-Bahrawy
No abstract text is available yet for this article.
December 2016: Pathology International
https://www.readbyqxmd.com/read/27862647/tumor-endothelial-cells-express-high-pentraxin-3-levels
#19
Kyoko Hida, Nako Maishi, Taisuke Kawamoto, Kosuke Akiyama, Noritaka Ohga, Yasuhiro Hida, Kenji Yamada, Takayuki Hojo, Hiroshi Kikuchi, Masumi Sato, Chisaho Torii, Nobuo Shinohara, Masanobu Shindoh
It has been described that tumor progression has many similarities to inflammation and wound healing in terms of the signaling processes involved. Among biological responses, angiogenesis, which is necessary for tumor progression and metastasis, is a common hallmark; therefore, tumor blood vessels have been considered as important therapeutic targets in anticancer therapy. We focused on pentraxin 3 (PTX3), which is a marker of cancer-related inflammation, but we found no reports on its expression and function in tumor blood vessels...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27860077/critical-in-vivo-roles-of-histamine-and-histamine-receptor-signaling-in-animal-models-of-metabolic-syndrome
#20
REVIEW
Sohsuke Yamada, Akihide Tanimoto, Yasuyuki Sasaguri
Histamine, a classic low-molecular-weight amine, is synthesized from L-histidine by histidine decarboxylase (HDC), and histamine-specific receptors (HRs) are essential for its actions. Our serial in vivo studies have uniquely reported that expression of histamine/HRs is variably identified in atherosclerotic lesions, and that HDC-gene knockout mice without histamine/HRs signaling show a marked reduction of atherosclerotic progression. These data have convinced us that histamine plays a pivotal role in the pathogenesis of atherosclerosis...
December 2016: Pathology International
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