journal
MENU ▼
Read by QxMD icon Read
search

Pathology International

journal
https://www.readbyqxmd.com/read/29222828/multiple-gastrointestinal-stromal-tumors-involving-extragastrointestinal-sites-in-neurofibromatosis-type-1
#1
LETTER
Keiko Segawa, Shintaro Sugita, Taro Sugawara, Yumika Ito, Mitsuhiro Tsujiwaki, Hiromi Fujita, Yusuke Ono, Kou Kobayashi, Megumi Hirobe, Makoto Yoshida, Tadashi Hasegawa
No abstract text is available yet for this article.
December 8, 2017: Pathology International
https://www.readbyqxmd.com/read/29222819/benign-mesothelial-nodules-reflux-within-acquired-cutaneous-lymphangiectasia-associated-with-huge-ovarian-clear-cell-carcinoma
#2
LETTER
Motona Kumagai, Sohsuke Yamada, Nozomu Kurose, Satoko Nakada, Akane Aikawa, Chizuru Futatsuya, Ken-Ichi Mizutani, Akihiro Shioya, Hiroshi Minato
No abstract text is available yet for this article.
December 8, 2017: Pathology International
https://www.readbyqxmd.com/read/29222812/spheroid-type-of-al-amyloid-deposition-associated-with-colonic-adenocarcinoma-a-case-report-with-literature-review
#3
Moon Joo Kim, Zulfia McCroskey, Yingchao Piao, Anna Belcheva, Luan Truong, Paul J Kurtin, Jae Y Ro
We report a colonic adenocarcinoma associated with diffuse submucosal deposition of a peculiar spheroid-type amyloid identified in the colon, terminal ileum, and appendix. A 65-year-old woman with past medical histories of hypertension, and chronic obstructive pulmonary disease, presented to the emergency room with cramping abdominal pain and nausea. A computed tomography (CT) scan of abdomen showed right colonic volvulus. Emergency right hemicolectomy was performed. The specimen showed colonic adenocarcinoma with focal submucosal invasion (pT1) arising from a villotubular adenoma...
December 8, 2017: Pathology International
https://www.readbyqxmd.com/read/29193597/mycotic-pseudoaneurysm-of-a-pulmonary-artery-branch-caused-by-cladosporium
#4
Keishin Sunagawa, Yoshihito Uchino, Shinichirou Ishimoto, Shigeki Nakamura, Taku Honma, Yoko Nakanishi, Yoshihiro Hatta, Yoshitsugu Miyazaki, Hiroyuki Sakurai, Hiroyuki Hao, Masahiko Sugitani
We report the case of a 53-year-old male with a history of acute myelogenous leukemia, who suffered the rupturing of a right-sided pulmonary artery pseudoaneurysm combined with pneumonia. He underwent a right-sided lower lobectomy. The resected lung tissue demonstrated a mycotic pseudoaneurysm of a pulmonary artery branch together with a filamentous fungal infection. Pseudoaneurysms are caused by the breaching of all layers of a blood vessel wall. The extravasated blood is trapped by the surrounding extravascular tissue or clots...
November 28, 2017: Pathology International
https://www.readbyqxmd.com/read/29154469/novel-non-alcoholic-steatohepatitis-model-with-histopathological-and-insulin-resistant-features
#5
Yohei Owada, Takafumi Tamura, Tomohito Tanoi, Yusuke Ozawa, Yoshio Shimizu, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Noriyuki Nakano, Shingo Sakashita, Toshiya Matsukawa, Hiroko Isoda, Nobuhiro Ohkohchi
Although several non-alcoholic steatohepatitis (NASH) models have been reported to date, few of these models fully reflect the histopathology and pathophysiology of human NASH. The aim of this study was to establish a novel NASH model by feeding a high-fat (HF) diet and administering both carbon tetrachloride (CCl4 ) and the Liver X receptor agonist T0901317. Male C57BL/6J mice were divided into four groups (each n = 5): HF, HF + CCl4 , HF + T0901317, and the novel NASH model (HF + CCl4  + T0901317)...
November 20, 2017: Pathology International
https://www.readbyqxmd.com/read/29131467/central-mucoepidermoid-carcinoma-arising-from-glandular-odontogenic-cyst-confirmed-by-analysis-of-maml2-rearrangement-a-case-report
#6
Atsuhiro Nagasaki, Ikuko Ogawa, Yukiko Sato, Kengo Takeuchi, Masae Kitagawa, Toshinori Ando, Shinnichi Sakamoto, Madhu Shrestha, Kaori Uchisako, Koichi Koizumi, Shigeaki Toratani, Masaru Konishi, Takashi Takata
Central mucoepidermoid carcinoma (MEC) poses a diagnostic challenge because of its rarity and histological overlap with glandular odontogenic cyst (GOC). In MEC of both salivary glands and jaws, MAML2 arrangement has been well known as the specific gene alteration. We report a case of central MEC arising from GOC diagnosed by MAML2 fusion gene. A 57-year-old male presented a multilocular cystic lesion in left molar region of the mandible. Histopathologically, multiple cysts lined by thin cuboidal or non-keratinized squamous epithelium with small duct-like structures, mucous cells and ciliated cells were present...
November 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29131458/image-analysis-is-an-excellent-tool-for-quantifying-ki-67-to-predict-the-prognosis-of-gastrointestinal-stromal-tumor-patients
#7
Shintaro Sugita, Hiroshi Hirano, Yutaka Hatanaka, Hiromi Fujita, Terufumi Kubo, Noriaki Kikuchi, Yumika Ito, Taro Sugawara, Keiko Segawa, Hiroyuki Hisai, Kentaro Yamashita, Takayuki Nobuoka, Yoshihiro Matsuno, Tadashi Hasegawa
We investigated the quantification of Ki-67 staining using digital image analysis (IA) as a complementary prognostic factor to the modified National Institutes of Health (NIH) classification in patients with gastrointestinal stromal tumor (GIST). We examined 92 patients, focusing on the correlation between age, sex, primary tumor site, tumor size, predominant histologic type, mitotic index, modified NIH classification (low/intermediate vs high), Ki-67 quantitation, and recurrence-free survival (RFS). We compared two IA processes for whole slide imaging (WSI) and manually captured image (MCI) methods...
November 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29127687/nuclear-inverse-polarity-papillary-lesions-lacking-myoepithelial-cells-a-report-of-two-cases
#8
Shinya Tajima, Ichiro Maeda, Yoshio Aida, Akio Kazama, Hirotaka Koizumi, Masatomo Doi, Akira Endo, Motohiro Chosokabe, Keiko Kishimoto, Takafumi Ono, Koichiro Tsugawa, Masayuki Takagi
Here, cases of a 68- (Case 1) and a 44-year-old (Case 2) female are presented. They had an abnormality in the breast, and came to our hospital for further examination and treatment. Radiologically, malignancy could not completely excluded so breast excision was performed. Histologically, both cases revealed papillary neoplastic lesions lined by fibrovascular core and nuclear inverse polarity without atypia. Loss of myoepithelial cells was observed by HE, p63, and calponin. Previous report indicate CK5/6, ER, p63 and MUC3 are important for distinguishing between papillary lesions according to the differential index (based on Allred score) of ([ER total score] + [MUC3 total score])/([CK5/6 total score] + [p63 total score] + 1)...
November 10, 2017: Pathology International
https://www.readbyqxmd.com/read/29090505/a-case-of-congenital-infantile-fibrosarcoma-of-the-bowel-presenting-as-a-neonatal-intussusception
#9
Juma Obayashi, Hirotaka Koizumi, Masahiro Hoshikawa, Munechika Wakisaka, Fujikawa Atsuko, Hiroaki Kitagawa, Masayuki Takagi
Neonatal intussusception of the intestinal tract is rare. However, most neonatal intussusceptions have an organic lead point. For the lead point to be a neoplasm is extremely rare. We report a case that presented with neonatal intussusception with a congenital infantile fibrosarcoma as the lead point. The detection of ETV6-NTRK3 gene fusion was useful, although the definitive diagnosis was achieved by a comprehensive evaluation including this gene analysis, standard histology and immunohistochemistry. Neonatal intussusception should be suspected to be caused by a neoplasm...
November 1, 2017: Pathology International
https://www.readbyqxmd.com/read/29090499/the-potential-significance-of-alpha-enolase-eno1-in-lung-adenocarcinomas-a-utility-of-the-immunohistochemical-expression-in-pathologic-diagnosis
#10
Koji Okudela, Hideaki Mitsui, Mai Matsumura, Hiromasa Arai, Kimihisa Shino, Akimasa Sekine, Tetsukan Woo, Takehisa Suzuki, Yoshihiro Ishikawa, Shigeaki Umeda, Michihiko Tajiri, Munetaka Masuda, Kenichi Ohashi
We herein analyzed the relationships among the immunohistochemical expression of alpha-enolase (ENO1) and clinicopathological factors in order to define the significance of ENO1 in lung adenocarcinomas (ADCs). ENO1 expression was detected in most of the ADCs examined (95.8%), but not in bronchial and alveolar epithelia. ENO1 expression was typically observed in the cytoplasm among most ADCs (95.8%), but was also detected in the nucleus (56.3%). The levels were significantly higher in terminal respiratory unit (TRU) cytological subtype ADCs...
November 1, 2017: Pathology International
https://www.readbyqxmd.com/read/29090496/primordial-odontogenic-tumor-a-case-report-with-histopathological-analyses
#11
Toshinari Mikami, Yu Ohashi, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Naoki Fujiwara, Naoko Tsunoda, Hiroyuki Yamada, Yasunori Takeda
Primordial odontogenic tumor (POT) is a benign mixed epithelial and mesenchymal odontogenic tumor included into the current World Health Organization (WHO) classification of Head and Neck tumours in 2017. As far as the authors have confirmed, only eight cases of this tumor have been reported so far. This paper reports a case of POT that occurred in the right mandible of a 5-year-old patient. Panoramic radiograph showed a well-defined homogeneous radiolucency displacing the unerupted second deciduous molar to the deep part of the mandible...
November 1, 2017: Pathology International
https://www.readbyqxmd.com/read/29086465/prognostic-significance-of-macroscopic-appearance-in-clear-cell-renal-cell-carcinoma-and-its-metastasis-predicting-model
#12
Se Un Jeong, Ja-Min Park, Su-Jin Shin, JungBok Lee, Cheryn Song, Heounjeong Go, Nam Hoon Cho, Jae Y Ro, Yong Mee Cho
Prognostic significance of macroscopic appearance of clear cell renal cell carcinoma (ccRCC) has not yet been studied. This study aimed to define the prognostic significance of macroscopic appearance and to propose a prognostic model for post-operative metastasis in ccRCC. A total of 1,025 patients with ccRCC were analyzed for the development dataset. A separate cohort of 399 such patients was used as an external validation dataset. Macroscopic appearances were initially divided into four groups, but were later divided into two groups: a simple nodular group (700 cases, 68...
October 30, 2017: Pathology International
https://www.readbyqxmd.com/read/29052290/pulmonary-langerhans-cell-histiocytosis-de-novo-after-lung-transplantation
#13
Javier Gómez-Román, María Teresa Zarrabeitia, Ana Santurtún, José Antonio Parra, Ainara Azueta Etxebarría, Jose M Cifrian, Javier Freire Salinas
A pulmonary Langerhans cell histiocytosis is presented in a 40 year-old woman two years after bilateral lung transplantation for emphysema without any signs of Langerhans cells proliferation in the explanted lungs. A microsatellite molecular analysis showed the proliferating cells were generated in a recipient cellular clone. The patient did not quit smoking after transplantation. No signs of disease were detected in the implanted lungs before surgery. Strict control of immunosupressive drug levels stabilized the disease...
October 20, 2017: Pathology International
https://www.readbyqxmd.com/read/29047227/telomerase-reverse-transcriptase-tert-promoter-mutations-are-rare-in-urachal-cancer
#14
Sebastian Thiem, Thomas Herold, Ulrich Krafft, Felix Bremmer, Yuri Tolkach, Attila M Szász, Joerg Kriegsmann, Nadine T Gaisa, Christian Niedworok, Tibor Szarvas, Henning Reis
High rates of telomerase reverse transcriptase (TERT) promoter mutations have recently been described in urothelial carcinoma (UC). Unlike UC in the bladder, adenocarcinomas account for the majority of urachal cancer (UrC) cases. As data in UrC is unclear, we analyzed TERT promoter mutations in a large cohort of UrC for its differential diagnostic, clinicopathological and prognostic significance. UrC cases from six academic centers were analyzed for c.-146C>T (C250T) and c.-124C>T (C228T) TERT promoter mutations by PCR and Sanger sequencing...
October 19, 2017: Pathology International
https://www.readbyqxmd.com/read/29047190/relationship-between-gastric-lanthanum-deposition-and-helicobacter-pylori-associated-chronic-gastritis-is-it-rare-or-common
#15
LETTER
Masaya Iwamuro, Haruo Urata, Hiroyuki Okada
No abstract text is available yet for this article.
October 19, 2017: Pathology International
https://www.readbyqxmd.com/read/29027306/fenton-reaction-induced-renal-carcinogenesis-in-mutyh-deficient-mice-exhibits-less-chromosomal-aberrations-than-the-rat-model
#16
Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26...
October 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29027312/cyclophilin-a-expression-and-its-prognostic-significance-in-lung-adenocarcinoma
#17
Noriyuki Nakano, Shingo Sakashita, Ryota Matsuoka, Yoshihiko Murata, Aya Shiba-Ishii, Naohiro Kobayashi, Yukio Sato, Masayuki Noguchi
Cyclophilin A (CypA) has been reported to be upregulated in malignant tumors. CypA expression is thought to be associated with acquisition of tumor growth and anti-apoptotic function. Although upregulation of CypA has been reported in lung adenocarcinoma, its clinicopathological significance and roles in malignant progression remain unclear. Here we investigated the implications of CypA expression for outcome in patients with lung adenocarcinoma. Lung adenocarcinoma specimens from 198 cases were selected and reclassified according to the World Health Organization classification (4th edition) and the Noguchi classification...
October 12, 2017: Pathology International
https://www.readbyqxmd.com/read/29027308/animal-models-for-analyzing-metabolic-syndrome-associated-liver-diseases
#18
REVIEW
Koichi Tsuneyama, Kazuchika Nishitsuji, Minoru Matsumoto, Tomoko Kobayashi, Yuki Morimoto, Takaaki Tsunematsu, Hirohisa Ogawa
Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases affecting the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH). NASH is known to progress to liver cirrhosis and hepatocellular carcinoma (HCC). Excellent animal models for determining the mechanism of pathogenesis and establishing therapeutic treatment of NASH/HCC are strongly required worldwide...
October 12, 2017: Pathology International
https://www.readbyqxmd.com/read/29027302/the-re-emerging-importance-of-radiologic-pathologic-correlation-in-reaching-the-pathology-diagnosis
#19
EDITORIAL
Monica Sze Man Chan, Ryoko Saito, Kei Takase, Yasuhiro Nakamura, Hironobu Sasano
No abstract text is available yet for this article.
October 12, 2017: Pathology International
https://www.readbyqxmd.com/read/29024210/a-case-of-anaplastic-lymphoma-kinase-positive-renal-cell-carcinoma-coincident-with-hodgkin-lymphoma
#20
Yuzo Oyama, Haruto Nishida, Takahiro Kusaba, Hiroko Kadowaki, Motoki Arakane, Tsutomu Daa, Dai Watanabe, Yasuyuki Akita, Fuminori Sato, Hiromitsu Mimata, Shigeo Yokoyama
We report a case of ALK-positive renal cell carcinoma coincident with Hodgkin lymphoma. The patient was a 19 year-old-girl without sickle cell trait. The right renal tumor was discovered concomitantly with Hodgkin lymphoma (HL). After chemotherapy for HL, right nephrectomy was performed. Microscopically, the tumor showed a solid and focally pseudo-papillary growth pattern studded with tubular structures. Most tumor cells were small bland eosinophilic cells, but rhabdoid cells, vacuolated cells, pleomorphic multinucleated giant cells were also admixed...
October 12, 2017: Pathology International
journal
journal
31934
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"