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Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society

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https://www.readbyqxmd.com/read/27930421/persistent-asymmetric-optic-disc-swelling-after-long-duration-space-flight-implications-for-pathogenesis
#1
Thomas H Mader, C Robert Gibson, Christian A Otto, Ashot E Sargsyan, Neil R Miller, Prem S Subramanian, Stephen F Hart, William Lipsky, Nimesh B Patel, Andrew G Lee
BACKGROUND: Several ophthalmic findings including optic disc swelling, globe flattening and choroidal folds have been observed in astronauts following long-duration space flight. The authors now report asymmetric choroidal expansion, disc swelling and optic disc morphologic changes in a 45-year-old astronaut which occurred during long-duration space flight and persisted following his space mission. METHODS: Case study of ocular findings in an astronaut documented during and after a long-duration space flight of approximately 6 months...
December 5, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27922461/ipsilateral-ophthalmic-and-cerebral-infarctions-after-cosmetic-polylactic-acid-injection-into-the-forehead
#2
Ashwinee Ragam, Steven A Agemy, Sarita B Dave, Azita S Khorsandi, Rudrani Banik
A 55-year-old woman developed no light perception vision in her right eye 5 days after an injection of polylactic acid cosmetic filler into her right forehead. Diffuse corneal edema and anterior chamber inflammation prohibited any view to the posterior segment to identify the cause of her profound vision loss. MRI of the orbits with diffusion-weighted imaging showed hyperintensity of the right optic nerve with signal reduction on apparent diffusion coefficient mapping, consistent with ischemia. Our patient also was found to have acute infarctions in the distribution of the right anterior cerebral artery on MRI of the brain despite having no permanent focal neurologic deficits aside from vision loss...
December 2, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27798429/leber-hereditary-optic-neuropathy-visual-recovery-in-a-patient-with-the-rare-m-3890g-a-point-mutation
#3
Jared J Murray, Kaitlyn W Nolan, Collin McClelland, Michael S Lee
A 15-year-old boy experienced painless vision loss in the left eye of unknown duration. Leber hereditary optic neuropathy (LHON) was suspected, despite negative testing for the 3 most common pathogenic gene mutations and idebenone 300 mg 3 times daily was prescribed. Nine months later, the patient developed right eye involvement. Complete mitochondrial genome analysis revealed 2 rare variants-m.3890G>A of the MT-ND1 gene and m.8417C>A of the MT-ATP8 gene. The former has been described in severe infantile Leigh syndrome and LHON; the latter is of unknown significance...
October 27, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27787462/comparing-hypertropia-in-upgaze-and-downgaze-distinguishes-congenital-from-acquired-fourth-nerve-palsies
#4
Yair Ivanir, Jonathan D Trobe
BACKGROUND: Isolated fourth nerve palsies are commonly caused by decompensation of a congenitally dysfunctional superior oblique muscle ("decompensated congenital palsies"). Distinguishing such palsies at initial presentation from palsies caused by presumed microvascular ischemia ("ischemic palsies") has value for patient reassurance and in forestalling ancillary testing. Abnormally large vertical fusional amplitudes traditionally have been used to identify decompensated congenital palsies, but that may not be a reliable distinguishing feature...
October 25, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27787461/temporary-lumbar-drain-as-treatment-for-pediatric-fulminant-idiopathic-intracranial-hypertension
#5
Kim Jiramongkolchai, Edward G Buckley, M Tariq Bhatti, Carrie R Muh, Robert E Wiggins, Pawina Jiramongkolchai, Mays A El-Dairi
Fulminant idiopathic intracranial hypertension (FIIH) is a subtype of idiopathic intracranial hypertension (IIH) characterized by rapid, severe, progressive vision loss. Surgical intervention is often performed either as a cerebrospinal fluid (CSF) shunt procedure or an optic nerve sheath fenestration or, at times, both. These surgical procedures carry a significant risk of morbidity and failure. We present 2 patients in whom a temporary lumbar drain was successfully used in the management of medically undertreated pediatric FIIH, and circumvented the need for surgical intervention...
October 25, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27759576/paraneoplastic-optic-neuropathy-associated-with-purkinje-cell-antibody-2-in-a-patient-with-small-cell-lung-cancer
#6
Jonathan A Micieli, Edward A Margolin
Paraneoplastic optic neuropathy (PON) is a rare cause of vision loss usually associated with small cell lung cancer. Patients with this condition usually test positive for anti-collapsin response mediating protein-5 (CRMP-5). We describe a case of a 57-year-old woman with bilateral vision loss with the characteristic features of CRMP-5 PON including bilateral optic disc edema and vitreous cells. However, she was negative for anti-CRMP-5 including a negative Western blot on two occasions, but positive for Purkinje Cell Antibody (PCA)-2...
October 17, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27749786/detection-of-thyroid-abnormalities-in-aquaporin-4-antibody-seropositive-optic-neuritis-patients
#7
Shuo Zhao, Huanfen Zhou, Xudong Peng, Shaoying Tan, Zihao Liu, Tingjun Chen, Quangang Xu, Shihui Wei
OBJECTIVE: This study retrospectively analyzed the frequency of anti-thyroid antibodies (ATAs) and thyroid disease in patients with optic neuritis (ON). METHODS: Tests of serum thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies and thyroid function were performed in 97 ON patients. Blood also was drawn to test for AQP4-Ab using cell-based and enzyme-linked immunosorbent assays. Comparisons of the frequencies of ATAs, thyroid diseases and thyroid function were performed based on AQP4-Ab status...
October 4, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27749773/horizontal-gaze-palsy-and-progressive-scoliosis-with-robo-3-mutations-in-patients-from-cape-verde
#8
Nadine B P S Mendes Marques, Sandra R Barros, Ana F Miranda, João Nobre Cardoso, Sónia Parreira, Teresa Fonseca, Nelvia M Donaire, Nuno Campos
Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare and autosomal recessive syndrome. We describe 2 cases of HGPPS which are the first documented in patients of African ancestry from an isolated population in Cape Verde. They demonstrated typical findings on neuro-ophthalmic examination and brain magnetic resonance imaging. One patient had novel heterozymous mutations of the ROB0 3 gene.
October 3, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27749399/transient-monocular-vision-loss-on-awakening-a-benign-amaurotic-phenomenon
#9
Marc A Bouffard, Wayne T Cornblath, Joseph F Rizzo, Michael S Lee, Lindsey B DeLott, Eric R Eggenberger, Nurhan Torun
BACKGROUND: Transient monocular vision loss (TMVL) is an alarming symptom owing to potentially serious etiologies such as thromboembolism or giant cell arteritis. Our objective is to describe the phenomenon of TMVL present on awakening, which may represent a distinct and benign entity. METHODS: We performed a retrospective observational case series of 29 patients who experienced TMVL on awakening. Patients who described monocular dimming or blackout of vision were included, and those with blurred vision, concurrent eye pain, and binocular vision loss were excluded...
September 29, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27749398/ocular-and-cerebral-emboli-from-an-atrial-myxoma
#10
Anne Kuonen, François-Xavier Borruat
Emboli from an atrial myxoma resulted in asymptomatic segmental retinal and choroidal arterial hyperfluorescent lesions on retinal angiography, mimicking an arteritis. The retinal lesions disappeared after removal of the atrial myxoma. Endothelial trauma by embolic material appears to be the mechanism of the angiographic findings.
September 29, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27669329/ciliary-body-iris-appositioning-producing-mechanical-pupillary-defects-in-carotid-cavernous-sinus-fistula-an-overlooked-pathophysiologic-mechanism
#11
Margarita G Todorova, Cameron F Parsa
BACKGROUND: Variable pupillary responses have been described with carotid-cavernous sinus fistulas. These often are associated with a decrease in visual acuity and attributed to retinal ischemia. We propose a novel pathophysiologic mechanism for changes in pupillary reactivity involving anatomic changes secondary to choroidal effusion. METHODS: To demonstrate proof-of-concept, we investigated 2 consecutive patients with carotid-cavernous sinus fistulas and pupillary disturbances using repeated refractions and anterior segment ultrasound biomicroscopy...
September 22, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27643747/cerebellar-control-of-eye-movements
#12
Shin C Beh, Teresa C Frohman, Elliot M Frohman
BACKGROUND: The cerebellum plays a central role in the online, real-time control, and long-term modulation of eye movements. EVIDENCE ACQUISITION: We reviewed the latest (fifth) edition of Leigh and Zee's textbook, The Neurology of Eye Movements, and literature in PUBMED using the following terms: cerebellum, flocculus, paraflocculus, vermis, oculomotor vermis, dorsal vermis, caudal fastigial nucleus, fastigial oculomotor region, uvula, nodulus, ansiform lobule, eye movements, saccades, ipsipulsion, contrapulsion, smooth pursuit, vergence, convergence, divergence, gaze-holding, down beat nystagmus, vestibulo-ocular reflex (VOR), angular VOR, translational VOR, skew deviation, velocity storage...
September 16, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27855129/temporal-arteritis-with-arteritic-anterior-ischemic-optic-neuropathy-is-bilateral-until-proven-otherwise-response
#13
Neil R Miller, Tin Yan Alvin Liu
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27855128/giant-cell-arteritis-with-arteritic-anterior-ischemic-optic-neuropathy-is-bilateral-until-proven-otherwise
#14
Nandini Singh, Adarsh George, Jeremy Tan, Shaun Y P Ewe, Ian C Francis
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27851718/food-and-drug-administration-adverse-event-reports-of-retinal-vascular-occlusions-associated-with-phosphodiesterase-type-5-inhibitor-use
#15
Albert S Li, Howard D Pomeranz
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27851717/central-trochlear-palsy-report-of-two-patients-with-ipsilesional-palsy-and-review-of-the-literature
#16
Seong-Hae Jeong, Sung-Hee Kim, Seung-Han Lee, Seong-Ho Park, Hyo-Jung Kim, Ji-Soo Kim
BACKGROUND: The trochlear (fourth) nerve is the only cranial nerve that decussates before emerging from the posterior aspect of the brainstem. Lesions involving the trochlear nucleus or fascicles mostly give rise to contralesional superior oblique palsy (SOP). METHODS: We report 2 patients with SOP on the side of intraaxial lesions with a literature review on central trochlear palsy. RESULTS: The lesions are more commonly located posterior to the cerebral aqueduct in patients with ipsilesional SOP than in those with contralesional SOP...
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27851716/optical-coherence-tomography-in-neuro-ophthalmology-do-we-really-need-it
#17
Mario L R Monteiro
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27798428/optic-gliomas-past-present-and-future
#18
Neil R Miller
No abstract text is available yet for this article.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27787463/literature-commentary
#19
(no author information available yet)
In this issue of Journal of Neuro-Ophthalmology, Tariq Bhatti, MD and Mark Moster, MD, will discuss the following 6 articles.
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27636747/avoiding-clinical-misinterpretation-and-artifacts-of-optical-coherence-tomography-analysis-of-the-optic-nerve-retinal-nerve-fiber-layer-and-ganglion-cell-layer
#20
John J Chen, Randy H Kardon
BACKGROUND: Optical coherence tomography (OCT) has become an important tool for diagnosing optic nerve disease. The structural details and reproducibility of OCT continues to improve with further advances in technology. However, artifacts and misinterpretation of OCT can lead to clinical misdiagnosis of diseases if they go unrecognized. EVIDENCE ACQUISITION: A literature review using PubMed combined with clinical and research experience. RESULTS: We describe the most common artifacts and errors in interpretation seen on OCT in both optic nerve and ganglion cell analyses...
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
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