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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/28791501/skeletal-muscle-mass-to-visceral-fat-area-ratio-is-an-important-determinant-affecting-hepatic-conditions-of-non-alcoholic-fatty-liver-disease
#1
Takashi Shida, Kentaro Akiyama, Sechang Oh, Akemi Sawai, Tomonori Isobe, Yoshikazu Okamoto, Kazunori Ishige, Yuji Mizokami, Kenji Yamagata, Kojiro Onizawa, Hironori Tanaka, Hiroko Iijima, Junichi Shoda
BACKGROUND: Not only obesity but also sarcopenia is associated with NAFLD. The influence of altered body composition on the pathophysiology of NAFLD has not been fully elucidated. The aim of this study is to determine whether skeletal muscle mass to visceral fat area ratio (SV ratio) affects NAFLD pathophysiology. METHODS: A total of 472 subjects were enrolled. The association between SV ratio and NAFLD pathophysiological factors was assessed in a cross-sectional nature by stratification analysis...
August 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28779419/complete-mucosal-healing-of-distal-lesions-induced-by-twice-daily-budesonide-2-mg-foam-promoted-clinical-remission-of-mild-to-moderate-ulcerative-colitis-with-distal-active-inflammation-double-blind-randomized-study
#2
Makoto Naganuma, Nobuo Aoyama, Tomohiro Tada, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Mamoru Watanabe, Toshifumi Hibi
BACKGROUND: Budesonide foam is used for the topical treatment of distal ulcerative colitis. This phase III study was performed to confirm mucosal healing and other therapeutic effects of twice-daily budesonide 2-mg foam in patients with mild-to-moderate ulcerative colitis including left-sided colitis and pancolitis. METHODS: This was a multicenter, randomized, placebo-controlled, double-blind trial. A total of 126 patients with mild-to-moderate ulcerative colitis with active inflammation in the distal colon were randomized to two groups receiving twice-daily budesonide 2 mg/25 ml foam or placebo foam...
August 4, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28770351/meta-analysis-proton-pump-inhibitors-moderately-increase-the-risk-of-small-intestinal-bacterial-overgrowth
#3
REVIEW
Tingting Su, Sanchuan Lai, Allen Lee, Xingkang He, Shujie Chen
The use of proton pump inhibitors (PPIs) may potentially predispose to the development of small intestinal bacterial overgrowth (SIBO), but this association is controversial due to conflicting results from studies conducted to date. The aim of this meta-analysis was to evaluate the association between the use of PPIs and the risk of SIBO. We systematically searched the online PubMed, Embase, and Cochrane Library databases and Web of Science for relevant articles published up to November 2016. Two researchers identified and extracted data independent of each other...
August 2, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28766016/transarterial-chemoembolization-with-miriplatin-vs-epirubicin-for-unresectable-hepatocellular-carcinoma-a-phase-iii-randomized-trial
#4
Masafumi Ikeda, Masatoshi Kudo, Hiroshi Aikata, Hiroaki Nagamatsu, Hiroshi Ishii, Osamu Yokosuka, Takuji Torimura, Manabu Morimoto, Kenji Ikeda, Hiromitsu Kumada, Tosiya Sato, Ikuko Kawai, Toru Yamashita, Hiroshi Horio, Takuji Okusaka
BACKGROUND: This prospective study investigated the superiority of transarterial chemoembolization (TACE) with miriplatin over TACE with epirubicin regarding overall survival (OS) in patients with unresectable hepatocellular carcinoma (HCC). METHODS: Patients with unresectable HCC were randomized 1:1 to receive TACE with miriplatin or epirubicin in lipiodol. The primary endpoint was OS; secondary endpoints were percentages of patients who achieved treatment effect (TE) 4 (100% necrotizing effect or tumor reduction), duration of time to TACE failure, and adverse events (AEs)...
August 1, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28744824/erratum-to-virological-and-clinical-characteristics-of-hepatitis-b-virus-genotype-a
#5
Kiyoaki Ito, Masashi Yoneda, Kazumasa Sakamoto, Masashi Mizokami
No abstract text is available yet for this article.
July 25, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28744823/combination-of-pnpla3-and-tll1-polymorphism-can-predict-advanced-fibrosis-in-japanese-patients-with-nonalcoholic-fatty-liver-disease
#6
Yuya Seko, Kanji Yamaguchi, Naoki Mizuno, Keiichiro Okuda, Masashi Takemura, Hiroyoshi Taketani, Tasuku Hara, Atsushi Umemura, Taichiro Nishikawa, Michihisa Moriguchi, Kohichiroh Yasui, Mai Kamaguchi, Kenichi Nishioji, Naomi Mochizuki, Masao Kobayashi, Kojiroh Mori, Saiyu Tanaka, Kentaro Matsuura, Yasuhito Tanaka, Yoshito Itoh
BACKGROUND: Hepatic fibrosis is an independent risk factor for mortality and liver-related events in patients with nonalcoholic fatty liver disease (NAFLD). PNPLA3 rs738409 has been associated with fibrosis in viral and non-viral hepatitis. TLL1 rs17047200 also has been associated with developing hepatocellular carcinoma probably via hepatic fibrogenesis. We estimated the impact of these genetic polymorphisms on hepatic fibrosis in Japanese patients with NAFLD. METHODS: We analyzed the association between these genetic variants and the backgrounds of 817 individuals who received health checkups (health check cohort) from 2012 to 2014...
July 25, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28744822/magnitude-and-direction-of-the-association-between-clostridium-difficile-infection-and-proton-pump-inhibitors-in-adults-and-pediatric-patients-a-systematic-review-and-meta-analysis
#7
Tadayuki Oshima, Liping Wu, Min Li, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
BACKGROUND: Clostridium difficile infection (CDI) is a cause of increased morbidity and health care costs among hospitalized patients. Proton pump inhibitors (PPIs) are mainly used for the treatment of acid-related upper gastrointestinal diseases. The aim of the study was to assess the risks associated with initial and recurrent CDI in adult and pediatric patients treated with PPIs. METHODS: A systematic search was performed using PubMed (Medline), Embase, and Web of Science with the following search terms: ("proton pump inhibitor," "PPI," or "acid suppression") AND ("infection," "diarrhea," "diarrhoea," "colitis," or "disease") AND ("Clostridium difficile")...
July 25, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28741271/supplementation-with-branched-chain-amino-acids-ameliorates-hypoalbuminemia-prevents-sarcopenia-and-reduces-fat-accumulation-in-the-skeletal-muscles-of-patients-with-liver-cirrhosis
#8
Yoichiro Kitajima, Hirokazu Takahashi, Takumi Akiyama, Kenichiro Murayama, Shinji Iwane, Takuya Kuwashiro, Kenichi Tanaka, Seiji Kawazoe, Naofumi Ono, Takahisa Eguchi, Keizo Anzai, Yuichiro Eguchi
BACKGROUND: Liver cirrhosis induces marked metabolic disorders, protein-energy malnutrition, and sarcopenia. The objective of the study reported here was to investigate the effects of dietary branched-chain amino acids (BCAAs) on systemic glucose metabolism, skeletal muscle, and prognosis of patients with liver cirrhosis. METHODS: Japanese patients with liver cirrhosis (n = 21) were enrolled into a longitudinal study in which their diets were supplemented with BCAAs...
July 24, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28741270/involvement-of-porphyromonas-gingivalis-in-the-progression-of-non-alcoholic-fatty-liver-disease
#9
Takashi Nakahara, Hideyuki Hyogo, Atsushi Ono, Yuko Nagaoki, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Nobuhiko Hiraga, Clair Nelson Hayes, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Hidenori Ochi, Hiromi Abe-Chayama, Hisako Furusho, Tomoaki Shintani, Hidemi Kurihara, Mutsumi Miyauchi, Takashi Takata, Koji Arihiro, Kazuaki Chayama
BACKGROUND AND AIMS: The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g infection on risk of progression to NASH. METHODS: (1) Serum IgG antibody titers against P.g fimbriae (fimA) in 200 biopsy-proven NAFLD patients were measured by ELISA and compared with histological findings...
July 24, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28687901/virological-and-clinical-characteristics-of-hepatitis-b-virus-genotype-a
#10
REVIEW
Kiyoaki Ito, Masashi Yoneda, Kazumasa Sakamoto, Masashi Mizokami
Hepatitis B virus (HBV) infection is one of the most prevalent chronic viral infections in humans. The overall prevalence of hepatitis B surface antigen (HBsAg) is reported to be 3.6%; however, it varies depending upon the geographic area. HBV is classified into ten genotypes (A through J) on the basis of an intergroup genomic divergence of > 8%. Specifically, HBV genotype A exhibits several unique virological and clinical characteristics and can be further classified into seven subtypes. Among them, subtype A2 or Ae (A2/[e]) is occasionally responsible for nosocomial infection and among homosexual males...
July 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28669071/effects-of-canagliflozin-an-sglt2-inhibitor-on-hepatic-function-in-japanese-patients-with-type-2-diabetes-mellitus-pooled-and-subgroup-analyses-of-clinical-trials
#11
Yuya Seko, Yoshio Sumida, Kazuyo Sasaki, Yoshito Itoh, Hiroaki Iijima, Toshio Hashimoto, Shinichi Ishii, Nobuya Inagaki
BACKGROUND: We aimed to investigate the efficacy of canagliflozin (based on its effect on liver function and blood glucose levels) and its safety in high alanine aminotransferase (ALT) patients (ALT >30 U/L). METHODS: This post hoc analysis of canagliflozin in type 2 diabetes mellitus (T2DM) patients was divided into Study 1 (pooled analysis of 12- and 24-week placebo-controlled, monotherapy studies) and Study 2 (52-week monotherapy/combination therapy study)...
July 1, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28664229/response-criteria-of-tolvaptan-for-the-treatment-of-hepatic-edema
#12
Yasunari Hiramine, Haruki Uojima, Hiroyuki Nakanishi, Akira Hiramatsu, Takuya Iwamoto, Mutsuumi Kimura, Hideto Kawaratani, Shuji Terai, Hitoshi Yoshiji, Hirofumi Uto, Isao Sakaida, Namiki Izumi, Kiwamu Okita, Kazuhiko Koike
BACKGROUND: Although tolvaptan is an effective treatment for hepatic edema, there are no established criteria for assessment of the therapeutic effect. The present study evaluates the association between body weight change and clinical symptoms to identify an effective indicator of tolvaptan response. METHODS: The study comprised 460 patients. The first data set contained 147 patients with hepatic edema who received tolvaptan in Kagoshima Kouseiren Hospital, a representative institution of this study...
June 29, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28660344/response-to-the-letter-by-lucijanic-et-al-regarding-our-manuscript-management-and-outcome-of-gastro-intestinal-bleeding-in-patients-taking-oral-anticoagulants-or-antiplatelet-drugs
#13
LETTER
https://www.readbyqxmd.com/read/28653082/clinical-practice-guideline-for-post-ercp-pancreatitis
#14
REVIEW
Tetsuya Mine, Toshio Morizane, Yoshiaki Kawaguchi, Ryukichi Akashi, Keiji Hanada, Tetsuhide Ito, Atsushi Kanno, Mitsuhiro Kida, Hiroyuki Miyagawa, Taketo Yamaguchi, Toshihiko Mayumi, Yoshifumi Takeyama, Tooru Shimosegawa
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERPC) is used for the diagnosis and treatment of pancreatic and biliary diseases. Post-ERCP pancreatitis (PEP) is a complication which needs special care and clinical practice guideline for this morbidity is also needed. METHODS: The key clinical issues of diagnosis and treatment of PEP were listed and checked, and then the clinical questions were formulated. PubMed (MEDLINE) and Ichushi-web (Japanese medical literature) were used as databases...
June 26, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28646417/mesenchymal-stem-cell-therapy-for-acute-and-chronic-pancreatitis
#15
REVIEW
Kazumichi Kawakubo, Shunsuke Ohnishi, Masaki Kuwatani, Naoya Sakamoto
Mesenchymal stem cells (MSCs) have attracted attention as a cell source for regenerative medicine. In particular, MSCs have an anti-inflammatory effect by secreting several kinds of bioactive molecules. MSC therapy is now being applied to various gastrointestinal diseases, such as graft-versus-host disease, inflammatory bowel disease, and liver cirrhosis. Therefore, MSC therapy has the potential to be a novel treatment for acute and chronic pancreatitis by suppressing inflammation. Several studies have investigated the effect of MSC therapy on acute and chronic pancreatitis, but the underlying mechanisms remain unknown...
June 23, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28634723/combinational-use-of-hepatitis-b-viral-antigens-predicts-responses-to-nucleos-t-ide-analogue-peg-interferon-sequential-therapy
#16
Akihiro Matsumoto, Shuhei Nishiguchi, Hirayuki Enomoto, Jong-Hon Kang, Yasuhito Tanaka, Noboru Shinkai, Masayuki Kurosaki, Masaru Enomoto, Tatsuo Kanda, Osamu Yokosuka, Hiroshi Yatsuhashi, Shinya Nagaoka, Chiaki Okuse, Tatehiro Kagawa, Tetsuya Mine, Koichi Takaguchi, Satoru Saito, Keisuke Hino, Fusao Ikeda, Shotaro Sakisaka, Daisuke Morihara, Shiho Miyase, Masataka Tsuge, Kazuaki Chayama, Naoki Hiramatsu, Yoshiyuki Suzuki, Kazumoto Murata, Eiji Tanaka
BACKGROUND: This prospective cohort study searched for factors associated with a response to nucleos(t)ide analogue/peg-interferon (NUC/peg-IFN) sequential therapy. METHODS: A total of 95 patients with chronic hepatitis B being treated with NUCs were enrolled. Immediately following NUC cessation, peg-IFN was administered at 180 µg/dose weekly for 48 weeks. RESULTS: Twenty-six patients (27%) were judged to be responders at 48 weeks after the completion of peg-IFN...
June 20, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28631049/novel-probiotics-isolated-from-a-japanese-traditional-fermented-food-funazushi-attenuates-dss-induced-colitis-by-increasing-the-induction-of-high-integrin-%C3%AE-v-%C3%AE-8-expressing-dendritic-cells
#17
Yoshikiyo Okada, Yoshikazu Tsuzuki, Takajo Takeshi, Hirotaka Furuhashi, Masaaki Higashiyama, Chikako Watanabe, Kazuhiko Shirakabe, Chie Kurihara, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Ryota Hokari
BACKGROUND: We isolated two novel probiotics strains (s193 and s292) from Funazushi, which is a traditional Japanese fermented food, and evaluated its effects on DSS-induced colitis to determine the possible underlying mechanisms. METHODS: A single colony from homogenized Funazushi was isolated by its ability to suppress TNF-α in RAW 264.7. Effect of probiotics on colonic inflammation induced by DSS was evaluated. Effect of probiotics on Treg induction by CD11c(+) dendritic cells (DCs) of MLNs were analyzed...
June 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28631048/celiac-disease-from-etiological-factors-to-evolving-diagnostic-approaches
#18
REVIEW
Anantdeep Kaur, Olga Shimoni, Michael Wallach
Celiac disease has advanced from a medical rarity to a highly prevalent disorder. Patients with the disease show varying degrees of chronic inflammation within the small intestine due to an aberrant immune response to the digestion of gliadin found in wheat. As a result, cytokines and antibodies are produced in celiac patients that can be used as specific biomarkers for developing diagnostic tests. This review paper describes celiac disease in terms of its etiological cause, pathological effects, current diagnostic tests based on mucosal biopsy, and the genetic basis for the disease...
June 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28623413/comment-to-management-and-outcome-of-gastrointestinal-bleeding-in-patients-taking-oral-anticoagulants-or-antiplatelet-drugs
#19
LETTER
Marko Lucijanic, Sead Ziga, Ivica Grgurevic
No abstract text is available yet for this article.
June 16, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28600597/comparison-of-propofol-with-midazolam-in-endoscopic-submucosal-dissection-for-esophageal-squamous-cell-carcinoma-a-randomized-controlled-trial
#20
Masaki Ominami, Yasuaki Nagami, Masatsugu Shiba, Kazunari Tominaga, Taishi Sakai, Hirotsugu Maruyama, Kunihiro Kato, Hiroaki Minamino, Shusei Fukunaga, Fumio Tanaka, Satoshi Sugimori, Noriko Kamata, Hirohisa Machida, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
BACKGROUND: Interruption of sedation due to a poor response to modified neuroleptanalgesia (m-NLA) with midazolam often occurs during endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma (ESCC) because most patients have a history of heavy alcohol intake. Recently, propofol has been used feasibly and safely during endoscopic procedures. The aim of this study was to clarify the efficacy and safety of propofol compared with that of midazolam during ESD for ESCC...
June 9, 2017: Journal of Gastroenterology
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