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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/30413874/response-to-the-letter-by-dr-naoya-yamada-and-dr-koichi-mizuta-regarding-our-manuscript-mac-2-binding-protein-glycan-isomer-m2bpgi-is-a-new-serum-biomarker-for-assessing-liver-fibrosis-more-than-a-biomarker-of-liver-fibrosis
#1
LETTER
Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, Kenichiro Araki, Norihiro Ishii, Atsushi Kuno, Hisashi Narimatsu, Masashi Mizokami
No abstract text is available yet for this article.
November 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30413873/advanced-assessment-of-serum-mac-2-binding-protein-glycosylation-isomer-in-patients-with-biliary-atresia
#2
LETTER
Naoya Yamada, Koichi Mizuta
No abstract text is available yet for this article.
November 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30413872/short-and-long-term-outcomes-of-endoscopic-submucosal-dissection-for-early-gastric-cancer-in-the-remnant-stomach-after-gastrectomy
#3
Yohei Yabuuchi, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka, Noboru Kawata, Masao Yoshida, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Hirotoshi Ishiwatari, Kinichi Hotta, Hiroyuki Matsubayashi, Hiroyuki Ono
BACKGROUND: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in the remnant stomach is a minimally invasive treatment. Few studies compared the technical difficulty of ESD involving the suture line and anastomosis, and information on long-term outcomes is insufficient. This study aimed to elucidate the short- and long-term outcomes of ESD for EGC in the remnant stomach. METHODS: We investigated patients who underwent ESD for EGC in the remnant stomach between September 2002 and March 2016...
November 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30406847/diagnostic-efficacy-of-dual-focus-endoscopy-with-narrow-band-imaging-using-simplified-dyad-criteria-for-superficial-esophageal-squamous-cell-carcinoma
#4
Akira Dobashi, Kenichi Goda, Hiroto Furuhashi, Hiroaki Matsui, Yuko Hara, Shunsuke Kamba, Masakuni Kobayashi, Kazuki Sumiyama, Shinichi Hirooka, Shigeharu Hamatani, Elizabeth Rajan, Masahiro Ikegami, Hisao Tajiri
BACKGROUND: Our previous studies have shown the diagnostic utility of a newly developed dual-focus endoscope with narrow-band imaging (DF-NBI) and simplified dyad criteria for detection of superficial esophageal squamous cell carcinoma (SESCC). This clinical trial aimed to study the diagnostic efficacy of DF-NBI with dyad criteria for detecting SESCC compared to white light imaging (WLI). METHODS: This was a single-arm prospective comparative trial. We enrolled 170 consecutive high-risk patients for esophageal squamous cell carcinoma...
November 8, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30406288/impact-of-endoscopic-ultrasonography-on-diagnosis-of-pancreatic-cancer
#5
REVIEW
Masayuki Kitano, Takeichi Yoshida, Masahiro Itonaga, Takashi Tamura, Keiichi Hatamaru, Yasunobu Yamashita
Accumulated evidence has revealed that endoscopic ultrasonography (EUS) has had a great impact on the clinical evaluation of pancreatic cancers. EUS can provide high-resolution images of the pancreas with a quality regarded as far surpassing that achieved on transabdominal ultrasound (US), computed tomography (CT), or magnetic resonance imaging (MRI). EUS is particularly useful for the detection of small pancreatic lesions, while EUS and its related techniques such as contrast-enhanced EUS (CE-EUS), EUS elastography, and EUS-guided fine needle aspiration (EUS-FNA) are also useful in the differential diagnosis of solid or cystic pancreatic lesions and the staging (T-staging, N-staging, and M-staging) of pancreatic cancers...
November 7, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30392013/antimicrobial-proteins-intestinal-guards-to-protect-against-liver-disease
#6
REVIEW
Tim Hendrikx, Bernd Schnabl
Alterations of gut microbes play a role in the pathogenesis and progression of many disorders including liver and gastrointestinal diseases. Both qualitative and quantitative changes in gut microbiota have been associated with liver disease. Intestinal dysbiosis can disrupt the integrity of the intestinal barrier leading to pathological bacterial translocation and the initiation of an inflammatory response in the liver. In order to sustain symbiosis and protect from pathological bacterial translocation, antimicrobial proteins (AMPs) such as a-defensins and C-type lectins are expressed in the gastrointestinal tract...
November 3, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30382364/deletion-of-ip-3-r1-by-pdgfrb-cre-in-mice-results-in-intestinal-pseudo-obstruction-and-lethality
#7
Hong Wang, Ran Jing, Christa Trexler, Yali Li, Huayuan Tang, Zhixiang Pan, Siting Zhu, Beili Zhao, Xi Fang, Jie Liu, Ju Chen, Kunfu Ouyang
BACKGROUND: Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are a family of intracellular Ca2+ release channels located on the membrane of endoplasmic reticulum, which have been shown to play critical roles in various cellular and physiological functions. However, their function in regulating gastrointestinal (GI) tract motility in vivo remains unknown. Here, we investigated the physiological function of IP3 R1 in the GI tract using genetically engineered mouse models. METHODS: Pdgfrb-Cre mice were bred with homozygous Itpr1 floxed (Itpr1f/f ) mice to generate conditional IP3 R1 knockout (pcR1KO) mice...
October 31, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30382363/tll1-variant-associated-with-development-of-hepatocellular-carcinoma-after-eradication-of-hepatitis-c-virus-by-interferon-free-therapy
#8
Etsuko Iio, Kentaro Matsuura, Noritomo Shimada, Masanori Atsukawa, Norio Itokawa, Hiroshi Abe, Keizo Kato, Koichi Takaguchi, Tomonori Senoh, Yuichiro Eguchi, Hideyuki Nomura, Kai Yoshizawa, Jong-Hon Kang, Takeshi Matsui, Noboru Hirashima, Atsunori Kusakabe, Tomokatsu Miyaki, Kei Fujiwara, Kayoko Matsunami, Susumu Tsutsumi, Katsuhiko Iwakiri, Yasuhito Tanaka
BACKGROUND: The aim of this study is to ascertain whether the TLL1 variant at rs17047200 is associated with the development of HCC after achieving sustained virological response (SVR) by interferon (IFN)-free therapy for chronic hepatitis C (CHC). METHODS: A total of 1029 Japanese CHC patients with the following inclusion criteria were enrolled: (i) achieved SVR by IFN-free therapy, (ii) followed up at least 1 year from the end of treatment (EOT) (median 104 weeks), (iii) no history of hepatocellular carcinoma (HCC) by 1 year from the EOT...
October 31, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30374622/a-multicenter-observational-study-on-the-clinicopathological-features-of-gastric-cancer-in-young-patients
#9
Yoshiyasu Kono, Hiromitsu Kanzaki, Takao Tsuzuki, Masahiro Takatani, Junichirou Nasu, Daisuke Kawai, Ryuta Takenaka, Takehiro Tanaka, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Toshiyoshi Fujiwara, Hiroyuki Okada
BACKGROUND: The details of gastric cancer in young patients remain unclear because of the low prevalence of the disease. This study aimed to clarify the clinicopathological features and prognosis of gastric cancer in young patients. METHODS: From January 2007 to January 2016, patients in their 20s and 30s who were diagnosed with primary gastric cancer at 4 hospitals were enrolled. Their clinical characteristics and prognosis were evaluated. RESULTS: The total number of patients was 72...
October 29, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30334096/real-world-efficacy-of-glecaprevir-plus-pibrentasvir-for-chronic-hepatitis-c-patient-with-previous-direct-acting-antiviral-therapy-failures
#10
Mitsutaka Osawa, Michio Imamura, Yuji Teraoka, Takuro Uchida, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C Nelson Hayes, Kazuaki Chayama
BACKGROUND: Combination therapy with glecaprevir (GLE) and pibrentasvir (PIB) has high efficacy for pan-genotypic hepatitis C virus (HCV)-infected patients. However, the efficacy of the therapy for failures to prior direct-acting antiviral (DAA) regimens in real-world practice is not well known. METHODS: Thirty patients infected with HCV genotype 1b, 2a, 2b, or 3a who failed to respond during prior DAA therapies were treated with GLE/PIB for 12 weeks. HCV NS3 and NS5A drug resistance-associated variants (RAVs) were determined by direct sequencing...
October 17, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30327875/sequential-h-pylori-eradication-and-radiation-therapy-with-reduced-dose-compared-to-standard-dose-for-gastric-malt-lymphoma-stages-ie-ii1e-a-prospective-randomized-trial
#11
Renate Schmelz, Stephan Miehlke, Christian Thiede, Stefan Brueckner, Monic Dawel, Matthias Kuhn, Agnes Ruskoné-Formestraux, Manfred Stolte, Christina Jentsch, Jochen Hampe, Andrea Morgner
BACKGROUND: In Helicobacter pylori (H. pylori) positive stage I gastric low-grade MALT lymphoma, eradication is the accepted first-line therapy. The role of eradication therapy in lymphoma > stage IE is still unclear. However, about 20% of patients show persistent lymphoma following successful eradication or primary H. pylori-negative lymphoma. A prospective study for salvage radiation therapy with standard 36 Gy in comparison to a reduced dose of 25.2 Gy is still missing. METHODS: A prospective, multicentre study investigated the efficacy of eradication in H...
October 16, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30298469/predictive-factors-of-the-treatment-outcome-in-patients-with-advanced-biliary-tract-cancer-receiving-gemcitabine-plus-cisplatin-as-first-line-chemotherapy
#12
Yuko Suzuki, Motoyasu Kan, Gen Kimura, Kumiko Umemoto, Kazuo Watanabe, Mitsuhito Sasaki, Hideaki Takahashi, Yusuke Hashimoto, Hiroshi Imaoka, Izumi Ohno, Shuichi Mitsunaga, Masafumi Ikeda
BACKGROUND: Few studies have clearly identified the prognostic factors in patients with advanced biliary tract cancer (BTC) receiving gemcitabine plus cisplatin (GC) which is acknowledged as standard chemotherapy regimen. OBJECTIVES: The aim of this study was to identify predictive factors of the overall survival (OS) in advanced BTC patients receiving GC therapy. METHODS: Data of 307 patients with advanced BTC who received GC therapy as the first-line chemotherapy at our institution from January 2007 to June 2017 were reviewed retrospectively...
October 8, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30291440/linked-color-imaging-can-enhance-recognition-of-early-gastric-cancer-by-high-color-contrast-to-surrounding-gastric-intestinal-metaplasia
#13
Hisashi Fukuda, Yoshimasa Miura, Hiroyuki Osawa, Takahito Takezawa, Yuji Ino, Masahiro Okada, Tsevelnorov Khurelbaatar, Alan Kawarai Lefor, Hironori Yamamoto
BACKGROUND: Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesions by color differences and color component values using LCI. METHODS: Fifty-two patients with early gastric cancer were enrolled. Color differences were calculated prospectively in malignant lesions and adjacent mucosa and compared with histological findings in resected specimens...
October 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30284617/clinical-significance-of-hepatic-steatosis-according-to-coronary-plaque-morphology-assessment-using-controlled-attenuation-parameter
#14
Hyo Eun Park, Heesun Lee, Su-Yeon Choi, Min-Sun Kwak, Jong In Yang, Jeong Yoon Yim, Goh Eun Chung
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) plays a significant role in coronary atherosclerosis, independent of shared metabolic risk factors. The measurement of the controlled attenuation parameter (CAP) has shown to allow early and noninvasive detection of NAFLD at subclinical stage. We evaluated the significance of CAP-defined NAFLD in association with the presence of any type of coronary plaques and different plaque compositions. METHODS: We conducted a retrospective cohort of apparently healthy subjects who had liver Fibroscan and coronary computed tomography during health screening exams...
October 4, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30284046/detection-of-gastritis-by-a-deep-convolutional-neural-network-from-double-contrast-upper-gastrointestinal-barium-x-ray-radiography
#15
Ren Togo, Nobutake Yamamichi, Katsuhiro Mabe, Yu Takahashi, Chihiro Takeuchi, Mototsugu Kato, Naoya Sakamoto, Kenta Ishihara, Takahiro Ogawa, Miki Haseyama
BACKGROUND: Deep learning has become a new trend of image recognition tasks in the field of medicine. We developed an automated gastritis detection system using double-contrast upper gastrointestinal barium X-ray radiography. METHODS: A total of 6520 gastric X-ray images obtained from 815 subjects were analyzed. We designed a deep convolutional neural network (DCNN)-based gastritis detection scheme and evaluated the effectiveness of our method. The detection performance of our method was compared with that of ABC (D) stratification...
October 3, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30251121/helicobacter-pylori-status-and-risks-of-metachronous-recurrence-after-endoscopic-resection-of-early-gastric-cancer-a-systematic-review-and-meta-analysis
#16
REVIEW
Shiyu Xiao, Sizhu Li, Liya Zhou, Wenjun Jiang, Jinzhe Liu
The impact of different Helicobacter pylori (H. pylori) status (H. pylori negative, H. pylori eradication and H. pylori persistence) on the development of metachronous gastric lesions after endoscopic resection of early gastric cancer is not well defined. Thus, a systematic review and meta-analysis was performed to investigate this relationship. Two authors independently searched the electronic databases (Pubmed, Embase, the Cochrane Library and Web of Science) through March 2018, without language restriction...
September 24, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30244399/progress-in-characterizing-the-linkage-between-fusobacterium-nucleatum-and-gastrointestinal-cancer
#17
REVIEW
Yang Liu, Yoshifumi Baba, Takatsugu Ishimoto, Masaaki Iwatsuki, Yukiharu Hiyoshi, Yuji Miyamoto, Naoya Yoshida, Rong Wu, Hideo Baba
Microbiome research is a rapidly advancing field in human cancers. Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. Recent studies have found that F. nucleatum can promote gastrointestinal tumor progression and affect the prognosis of the disease. In addition, F. nucleatum may contribute to the chemo-resistance of gastrointestinal cancers. This review summarizes recent progress in the pathogenesis of F. nucleatum and its impact on gastrointestinal cancer...
September 22, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30244398/anti-tumor-necrosis-factor-therapy-decreases-the-risk-of-initial-intestinal-surgery-after-diagnosis-of-crohn-s-disease-of-inflammatory-type
#18
Yutaka Nagata, Motohiro Esaki, Tomohiko Moriyama, Atsushi Hirano, Junji Umeno, Yuji Maehata, Takehiro Torisu, Takayuki Matsumoto, Takanari Kitazono
BACKGROUND: Anti-tumor necrosis factor (TNF) therapy induces and maintains clinical remission in patients with Crohn's disease (CD). However, the effect of anti-TNF therapy on the natural course of CD remains controversial. We aimed to investigate the effect of anti-TNF therapy on the initial intestinal surgery for CD. METHODS: In this single-center retrospective cohort study, clinical course of 199 CD patients of inflammatory type at the initial diagnosis (the period between 1973 and 2014) was precisely reviewed until the end of 2016...
September 22, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30242476/tumor-specific-genetic-aberrations-in-cell-free-dna-of-gastroesophageal-cancer-patients
#19
REVIEW
Kristina Magaard Koldby, Michael Bau Mortensen, Sönke Detlefsen, Per Pfeiffer, Mads Thomassen, Torben A Kruse
The applicability of liquid biopsies is studied intensively in all types of cancer and analysis of circulating tumor DNA (ctDNA) has recently been implemented clinically for mutation detection in lung cancer. ctDNA may provide information about tumor quantity and mutations present in the tumor, and as such have many potential applications in diagnosis and treatment of cancer. It has been suggested that ctDNA analysis may overcome the issue of intra-tumor heterogeneity faced by tissue biopsies and serve as an additional diagnostic tool...
September 21, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30232597/the-role-of-small-intestinal-bacterial-overgrowth-in-cystic-fibrosis-a-randomized-case-controlled-clinical-trial-with-rifaximin
#20
Manuele Furnari, Alessandra De Alessandri, Federico Cresta, Maria Haupt, Marta Bassi, Angela Calvi, Riccardo Haupt, Giorgia Bodini, Iftikhar Ahmed, Francesca Bagnasco, Edoardo Giovanni Giannini, Rosaria Casciaro
BACKGROUND: Scientific literature shows a high prevalence of Small Intestinal Bacterial Overgrowth (SIBO) in patients with Cystic Fibrosis (CF). The role of SIBO in nutritional status and gastrointestinal symptoms in CF is not known. Our aim was to study epidemiology and clinical impact of SIBO while assessing the efficacy of rifaximin in eradicating SIBO in CF patients. METHODS: Symptoms questionnaire and Glucose Breath Test (GBT) were given to 79 CF patients (median age 19...
September 19, 2018: Journal of Gastroenterology
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