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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/28534191/tgf-%C3%AE-in-inflammatory-bowel-disease-a-key-regulator-of-immune-cells-epithelium-and-the-intestinal-microbiota
#1
REVIEW
Sozaburo Ihara, Yoshihiro Hirata, Kazuhiko Koike
Inflammatory bowel disease (IBD) is defined as chronic intestinal inflammation, and includes ulcerative colitis and Crohn's disease. Multiple factors are involved in the pathogenesis of IBD, and the condition is characterized by aberrant mucosal immune reactions to intestinal microbes in genetically susceptible hosts. Transforming growth factor-β (TGF-β) is an immune-suppressive cytokine produced by many cell types and activated by integrins. Active TGF-β binds to its receptor and regulates mucosal immune reactions through the TGF-β signaling pathway...
May 22, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28501919/automated-cytological-detection-of-barrett-s-neoplasia-with-infrared-spectroscopy
#2
Oliver Old, Gavin Lloyd, Martin Isabelle, L Max Almond, Catherine Kendall, Karol Baxter, Neil Shepherd, Angela Shore, Nick Stone, Hugh Barr
BACKGROUND: Development of a nonendoscopic test for Barrett's esophagus would revolutionize population screening and surveillance for patients with Barrett's esophagus. Swallowed cell collection devices have recently been developed to obtain cytology brushings from the esophagus: automated detection of neoplasia in such samples would enable large-scale screening and surveillance. METHODS: Fourier transform infrared (FTIR) spectroscopy was used to develop an automated tool for detection of Barrett's esophagus and Barrett's neoplasia in esophageal cell samples...
May 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28493007/gastrointestinal-endoscopy-in-patients-receiving-novel-direct-oral-anticoagulants-results-from-the-prospective-dresden-noac-registry
#3
Vera Heublein, Sven Pannach, Katharina Daschkow, Luise Tittl, Jan Beyer-Westendorf
BACKGROUND: Patients receiving direct-acting, non-vitamin K oral anticoagulants (NOAC) frequently undergo gastrointestinal endoscopies (GIE) but little is known on the management and outcome of these interventions. METHODS: With use of data from an ongoing, prospective, noninterventional registry of NOAC patients, the management and outcome of GIE were evaluated with use of standard event definitions. Patients undergoing GIE were categorized into two subgroups: (1) scheduled GIE (scheduled appointment, no acute bleeding) and (2) unscheduled GIE (unscheduled including management of acute gastrointestinal bleeding)...
May 10, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28488114/a-simple-morphological-classification-to-estimate-the-malignant-potential-of-pancreatic-neuroendocrine-tumors
#4
Atsushi Oba, Atsushi Kudo, Keiichi Akahoshi, Mitsuhiro Kishino, Takumi Akashi, Eriko Katsuta, Yasuhito Iwao, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Shinji Tanaka, Yoshinobu Eishi, Ukihide Tateishi, Minoru Tanabe
BACKGROUND: A novel morphological classification using resected specimens predicted malignant potential and prognosis in patients with pancreatic neuroendocrine tumors (P-NETs). The aim of this study was to examine the predictive ability of morphological diagnoses made using non-invasive multi-detector computed tomography (MDCT) in P-NETs. METHODS: Between 2002 and 2015, 154 patients were diagnosed with P-NETs at the Tokyo Medical and Dental University, and 82 patients who underwent surgical treatment were enrolled...
May 9, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28478523/factors-associated-with-delayed-hemorrhage-after-endoscopic-sphincterotomy-japanese-large-single-center-experience
#5
Satoshi Ikarashi, Akio Katanuma, Toshifumi Kin, Kuniyuki Takahashi, Kei Yane, Itsuki Sano, Hajime Yamazaki, Hiroyuki Maguchi
BACKGROUND: Hemorrhage is one of the serious adverse events of endoscopic sphincterotomy (EST). However, the risk factors for delayed hemorrhage after EST have not been clarified. The aim of this study was to examine the risk factors for delayed hemorrhage after EST. METHODS: Consecutive patients who underwent EST between January 2011 and December 2015 were analyzed retrospectively. The incidence, treatment outcomes, and risk factors for delayed hemorrhage were evaluated...
May 6, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28477171/wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-level-increases-in-patients-with-acute-liver-injury
#6
Kei Morio, Michio Imamura, Kana Daijo, Yuji Teraoka, Fumi Honda, Yuki Nakamura, Tomoki Kobayashi, Takashi Nakahara, Yuko Nagaoki, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Yoshiiku Kawakami, Hiroshi Aikata, Clair Nelson Hayes, Kazuko Tsugawa, Michiya Yokozaki, Kazuaki Chayama
BACKGROUND: Wisteria floribunda agglutinin positive human Mac-2-binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker for liver fibrosis. However, it is not known whether or not M2BPGi reflects only liver fibrosis. We measured serum M2BPGi levels in patients with acute liver injury. METHODS: Fifty-one patients with acute liver injury were enrolled. M2BPGi levels were measured at the initial visit and at achievement of recovery. The relationship between M2BPGi values at the initial visit and clinical outcomes was analyzed...
May 5, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28474222/serum-hmgb1-concentrations-at-4%C3%A2-weeks-is-a-useful-predictor-of-extreme-poor-prognosis-for-advanced-hepatocellular-carcinoma-treated-with-sorafenib-and-hepatic-arterial-infusion-chemotherapy
#7
Kazuhiko Masuda, Atsushi Ono, Hiroshi Aikata, Tomokazu Kawaoka, C Nelson Hayes, Yuji Teraoka, Kana Daijo, Yuki Nakamura-Inagaki, Kei Morio, Hatsue Fujino, Hiromi Kan, Takuro Uchida, Keiichi Masaki, Tomoki Kobayashi, Takashi Nakahara, Grace Naswa Makokha, Yizhou Zhang, Yuko Nagaoki, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiromi Abe-Chayama, Yoshiiku Kawakami, Hidenori Ochi, Kazuaki Chayama
BACKGROUND: Biomarkers predicting the response to the anticancer treatment and prognosis in patients with advanced hepatocellular carcinoma (HCC) are required. Recently, high mobility group box 1 (HMGB1) was reported to promote HCC progression and be associated with poor prognosis for patients with HCC. The purpose of this study was to assess serum HMGB1 concentrations before and during sorafenib treatment or hepatic arterial infusion chemotherapy (HAIC) and to explore the ability of serum HMGB1 concentrations to predict prognosis...
May 4, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28451845/reflux-esophagitis-and-its-role-in-the-pathogenesis-of-barrett-s-metaplasia
#8
REVIEW
Rhonda Frances Souza
Reflux esophagitis damages the squamous epithelium that normally lines the esophagus, and promotes replacement of the damaged squamous lining by the intestinal metaplasia of Barrett's esophagus, the precursor of esophageal adenocarcinoma. Therefore, to prevent the development of Barrett's metaplasia and esophageal adenocarcinoma, the pathogenesis of reflux esophagitis must be understood. We have reported that reflux esophagitis, both in a rat model and in humans, develops as a cytokine-mediated inflammatory injury (i...
April 27, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28447174/erratum-to-early-diagnosis-of-pancreatic-necrosis-based-on-perfusion-ct-to-predict-the-severity-of-acute-pancreatitis
#9
Yoshihisa Tsuji, Naoki Takahashi, Hiroyoshi Isoda, Koji Koizumi, Sho Koyasu, Miho Sekimoto, Yuichi Imanaka, Shujiro Yazumi, Masanori Asada, Yoshihiro Nishikawa, Hiroshi Yamamoto, Osamu Kikuchi, Tsukasa Yoshida, Tetsuro Inokuma, Shinji Katsushima, Naoki Esaka, Akihiro Okano, Chiharu Kawanami, Nobuyuki Kakiuchi, Masahiro Shiokawa, Yuzo Kodama, Ichiro Moriyama, Takafumi Kajitani, Yoshikazu Kinoshita, Tsutomu Chiba
No abstract text is available yet for this article.
April 26, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28424989/t-lymphocyte-derived-enkephalins-reduce-th1-th17-colitis-and-associated-pain-in-mice
#10
Lilian Basso, Laure Garnier, Arnaud Bessac, Jérôme Boué, Catherine Blanpied, Nicolas Cenac, Sophie Laffont, Gilles Dietrich
BACKGROUND: Endogenous opioids, including enkephalins, are fundamental regulators of pain. In inflammatory conditions, the local release of opioids by leukocytes at the inflammatory site inhibits nociceptor firing, thereby inducing analgesia. Accordingly, in chronic intestinal Th1/Th17-associated inflammation, enkephalins released by colitogenic CD4(+) T lymphocytes relieve inflammation-induced visceral pain. The present study aims to investigate whether mucosal T-cell-derived enkephalins also exhibit a potent anti-inflammatory activity as described for exogenous opioid drugs in Th1/Th17-associated colitis...
April 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28405767/erratum-to-four-year-maintenance-treatment-with-adalimumab-in-japanese-patients-with-moderately-to-severely-active-ulcerative-colitis
#11
Yasuo Suzuki, Satoshi Motoya, Hiroyuki Hanai, Toshifumi Hibi, Shiro Nakamura, Andreas Lazar, Anne Martin Robinson, Martha Skup, Nael Mohamed Mostafa, Bidan Huang, Roopal Thakkar, Mamoru Watanabe
No abstract text is available yet for this article.
April 12, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28396998/operative-and-medical-treatment-of-chronic-anal-fissures-a-review-and-network-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Sabrina Maria Ebinger, Julia Hardt, René Warschkow, Bruno Martin Schmied, Alexander Herold, Stefan Post, Lukas Marti
Anal fissures are a common problem and have a cumulative lifetime incidence of 11%. Previous reviews on anal fissures show inconsistent results regarding post-interventional healing and incontinence rates. In this review our aim was to compare the treatments for chronic anal fissures by incorporating indirect comparisons using network meta-analysis. The PubMed database was searched for randomized controlled trials (RCTs) published between 1975 and 2015. The primary outcome measures were healing and incontinence rates after lateral internal sphincterotomy (LIS), anal dilatation (DILA), anoplasty and/or fissurectomy (FIAP), botulinum toxin (BT) and noninvasive treatment (NIT)...
April 10, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28389733/celiac-disease-in-non-clinical-populations-of-japan
#13
Mai Fukunaga, Norihisa Ishimura, Chika Fukuyama, Daisuke Izumi, Nahoko Ishikawa, Asuka Araki, Akihiko Oka, Tomoko Mishiro, Shunji Ishihara, Riruke Maruyama, Kyoichi Adachi, Yoshikazu Kinoshita
BACKGROUND: Celiac disease is a chronic autoimmune enteropathy caused by gluten ingestion. While its prevalence in Western countries is reported to be as high as 1%, the prevalence has not been evaluated in a large-scale study of a Japanese population. The aim of our study was to clarify the possible presence of celiac disease in a Japanese non-clinical population as well as in patients showing symptoms suggestive of the disease. METHODS: Serum samples were collected from 2008 non-clinical adults and 47 patients with chronic unexplained abdominal symptoms between April 2014 and June 2016...
April 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28389732/clinical-and-microbiological-features-of-infection-in-alcoholic-hepatitis-an-international-cohort-study
#14
Richard Parker, Gene Im, Fiona Jones, Onan Pérez Hernández, Jonathan Nahas, Aditi Kumar, Daniel Wheatley, Ashish Sinha, Emilio Gonzalez-Reimers, María Sanchez-Pérez, Antonella Ghezzi, Miruna Delia David, Christopher Corbett, Anne McCune, Guruprasad Padur Aithal, Andrew Holt, Stephen Stewart
BACKGROUND: Previous studies have described the clinical impact of infection in alcoholic hepatitis (AH) but none have comprehensively explored the aetiopathogenesis of infection in this setting. We examined the causes, consequences and treatment of infection in a cohort of patients with AH. METHODS: We undertook a retrospective cohort study of patients with AH admitted between 2009 and 2014 to seven centres in Europe and the USA. Clinical and microbiological data were extracted from medical records...
April 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28389731/esophageal-cancer-stem-cells-are-suppressed-by-tranilast-a-trpv2-channel-inhibitor
#15
Atsushi Shiozaki, Michihiro Kudou, Daisuke Ichikawa, Hitoshi Fujiwara, Hiroki Shimizu, Takeshi Ishimoto, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Shuhei Komatsu, Kazuma Okamoto, Yoshinori Marunaka, Eigo Otsuji
BACKGROUND: Recent evidence suggests that the targeting of membrane proteins specifically activated in cancer stem cells (CSCs) is an important strategy for cancer therapy. The objectives of the present study were to investigate the expression and activity of ion-transport-related molecules in the CSCs of esophageal squamous cell carcinoma. METHODS: Cells exhibiting strong aldehyde dehydrogenase 1 family member A1 (ALDH1A1) activity were isolated from TE8 cells by fluorescence-activated cell sorting, and CSCs were then generated with the sphere formation assay...
April 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28382402/a-cohort-study-on-helicobacter-pylori-infection-associated-with-nonalcoholic-fatty-liver-disease
#16
Tae Jun Kim, Dong Hyun Sinn, Yang Won Min, Hee Jung Son, Jae J Kim, Yoosoo Chang, Sun-Young Baek, Soo Hyun Ahn, Hyuk Lee, Seungho Ryu
BACKGROUND: Previous studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet large-scale longitudinal studies are lacking to elucidate this association. METHODS: A cohort study of 17,028 adults without NAFLD at baseline, who participated in a repeated health screening examination including an H. pylori-specific immunoglobulin G antibody test, was conducted to evaluate the association between H...
April 5, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28374057/early-diagnosis-of-pancreatic-necrosis-based-on-perfusion-ct-to-predict-the-severity-of-acute-pancreatitis
#17
Yoshihisa Tsuji, Naoki Takahashi, Hiroyoshi Isoda, Koji Koizumi, Sho Koyasu, Miho Sekimoto, Yuichi Imanaka, Shujiro Yazumi, Masanori Asada, Yoshihiro Nishikawa, Hiroshi Yamamoto, Osamu Kikuchi, Tsukasa Yoshida, Tetsuro Inokuma, Shinji Katsushima, Naoki Esaka, Akihiro Okano, Chiharu Kawanami, Nobuyuki Kakiuchi, Masahiro Shiokawa, Yuzo Kodama, Ichiro Moriyama, Takafumi Kajitani, Yoshikazu Kinoshita, Tsutomu Chiba
BACKGROUND: Perfusion CT can diagnose pancreatic necrosis in early stage of severe acute pancreatitis, accurately. However, no study to date has examined whether early diagnosis of pancreatic necrosis is useful in predicting persistent organ failure (POF). METHODS: We performed a multi-center prospective observational cohort study to investigate whether perfusion CT can predict the development of POF in the early stage of AP, based on early diagnosis of the development of pancreatic necrosis (PN)...
April 3, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28365879/geoepidemiology-and-changing-mortality-in-primary-biliary-cholangitis
#18
REVIEW
Annarosa Floreani, Atsushi Tanaka, Christopher Bowlus, Merrill Eric Gershwin
Primary biliary cholangitis (PBC), formerly called primary biliary cirrhosis, is a chronic cholestatic disease characterized by an autoimmune-mediated destruction of small and medium-sized intrahepatic bile ducts. Originally PBC was considered to be rare and almost invariably fatal, mainly because the diagnosis was made in patients presenting with advanced symptomatic disease (jaundice and decompensated cirrhosis). However, the development of a reproducible indirect immunofluorescence assay for antimitochondrial antibody made it possible to diagnose the disease at an earlier stage, and introduction of ursodeoxycholic acid therapy as the first-line therapy for PBC drastically changed PBC-related mortality...
April 1, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28364190/pu-erh-tea-extract-mediated-protection-against-hepatosteatosis-and-insulin-resistance-in-mice-with-diet-induced-obesity-is-associated-with-the-induction-of-de-novo-lipogenesis-in-visceral-adipose-tissue
#19
Xianbin Cai, Shuhei Hayashi, Chongye Fang, Shumei Hao, Xuanjun Wang, Shuhei Nishiguchi, Hiroko Tsutsui, Jun Sheng
BACKGROUND: White adipose tissue (WAT) is important for the maintenance of metabolic homeostasis, and metabolic syndrome is sometimes associated with WAT dysfunction in humans and animals. WAT reportedly plays a key, beneficial role in the maintenance of glucose and lipid homeostasis during de novo lipogenesis (DNL). Pu'erh tea extract (PTE) can inhibit harmful, ectopic DNL in the liver, thus protecting against hepatosteatosis, in mice with diet-induced obesity. We examined whether PTE could induce DNL in WAT and consequently protect against hepatosteatosis...
March 31, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28353014/deep-sequencing-analysis-of-quasispecies-in-the-hbv-pre-s-region-and-its-association-with-hepatocellular-carcinoma
#20
An-Ye Zhang, Ching-Lung Lai, Fung-Yu Huang, Wai-Kay Seto, James Fung, Danny Ka-Ho Wong, Man-Fung Yuen
BACKGROUND: The association between the evolution of hepatitis B virus (HBV) quasispecies and the development of hepatocellular carcinoma (HCC) is unknown. METHODS: We used deep sequencing to examine the dynamics of HBV quasispecies and their relationship to HCC development. Thirty-two chronic hepatitis B (CHB) patients with HCC (HCC group) and 32 matched CHB patients without HCC (controls) were recruited. Fourteen patients from each group had serial sera available up to 9 years before the time of the present study...
March 28, 2017: Journal of Gastroenterology
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