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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/30006904/hepatocellular-carcinoma-as-a-leading-cause-of-cancer-related-deaths-in-japanese-type-2-diabetes-mellitus-patients
#1
Toshihide Shima, Hirofumi Uto, Kohjiro Ueki, Yutaka Kohgo, Kohichiroh Yasui, Naoto Nakamura, Tatsuaki Nakatou, Toshinari Takamura, Sumio Kawata, Kazuo Notsumata, Kyoko Sakai, Ryosuke Tateishi, Takeshi Okanoue
BACKGROUND: We reported a cross-sectional study on causes of liver injury in Japanese type 2 diabetes mellitus (T2D) patients (JG 2013). We assessed overall and cause-specific mortality risk during follow-up of patients enrolled in JG 2013. METHODS: This was a longitudinal, multicenter cohort study. Of the 5642 Japanese T2D patients who visited T2D clinics of nine hospitals in the original study, 3,999 patients were followed up for an average of 4.5 years. Expected deaths in T2D patients were estimated using age-specific mortality rates in the general population (GP) of Japan...
July 13, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30003334/microbial-biomarkers-for-immune-checkpoint-blockade-therapy-against-cancer
#2
REVIEW
Keishi Adachi, Koji Tamada
Three major standard treatments, i.e., surgery, chemotherapy, and radiotherapy, were traditionally applied to the treatment of cancer and saved many patients. Meanwhile, clinical studies as well as basic research of immunotherapy are being actively conducted for intractable or advanced malignancies that cannot be cured by the conventional standard treatments. Remarkable therapeutic efficacies have been recently reported in clinical trials on some cancer types, and immunotherapy is now being recognized as the "fourth" standard therapy against cancer...
July 12, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29980848/the-state-of-the-art-on-treatment-of-crohn-s-disease
#3
REVIEW
Hai Yun Shi, Siew Chien Ng
Crohn's disease (CD) is a chronic, progressive, and destructive disease of the gastrointestinal tract. Although its incidence appears to be stable or decreasing in most countries in the North America and Europe, the incidence is rising rapidly in Asian countries. Immunomodulators and biologics are increasingly used to avoid long-term bowel damage and subsequent disability. Therapeutic drug monitoring facilitates optimizing thiopurines and anti-TNFs use. New biologic agents targeting various pathological pathways of CD are blooming in recent years, and the high cost of biologics and expiration of patents for several biologic agents have driven the utility of biosimilars for CD treatment...
July 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29980847/the-real-world-efficacy-and-safety-of-daas-for-the-treatment-of-hcv-patients-throughout-japan
#4
EDITORIAL
Shinya Maekawa, Nobuyuki Enomoto
No abstract text is available yet for this article.
July 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29971498/a-genetic-variant-located-in-the-mir-532-5p-binding-site-of-tgfbr1-is-associated-with-the-colorectal-cancer-risk
#5
Dongying Gu, Shuwei Li, Mulong Du, Cuiju Tang, Haiyan Chu, Na Tong, Zhengdong Zhang, Meilin Wang, Jinfei Chen
BACKGROUND: Genome-wide association studies have identified genes in the transforming growth factor-β (TGFβ) signaling pathway that are responsible for regulating carcinogenesis. METHODS: We searched for single-nucleotide polymorphisms (SNPs) located within 3'-untranslated regions (3'-UTRs) that might affect the ability of miRNAs to bind genes in the TGFβ pathway for further analysis. We used TaqMan technology to genotype these SNPs in a population-based case-control study of 1147 colorectal cancer patients and 1203 matched controls in a Chinese population...
July 3, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29961130/endoscopic-diagnosis-and-treatment-of-esophageal-adenocarcinoma-introduction-of-japan-esophageal-society-classification-of-barrett-s-esophagus
#6
REVIEW
Ryu Ishihara, Kenichi Goda, Tsuneo Oyama
Endoscopic surveillance of Barrett's esophagus has become a foundation of the management of esophageal adenocarcinoma (EAC). Surveillance for Barrett's esophagus commonly involves periodic upper endoscopy with biopsies of suspicious areas and random four-quadrant biopsies. However, targeted biopsies using narrow-band imaging can detect more dysplastic areas and thus reduce the number of biopsies required. Several specific mucosal and vascular patterns characteristic of Barrett's esophagus have been described, but the proposed criteria are complex and diverse...
June 30, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29951927/identification-of-marker-genes-and-pathways-specific-to-precancerous-duodenal-adenomas-and-early-stage-adenocarcinomas
#7
Yoshiki Sakaguchi, Nobutake Yamamichi, Shuta Tomida, Chihiro Takeuchi, Natsuko Kageyama-Yahara, Yu Takahashi, Kazuya Shiogama, Ken-Ichi Inada, Masao Ichinose, Mitsuhiro Fujishiro, Kazuhiko Koike
BACKGROUND: The mechanism behind the pathogenesis and carcinogenesis of these neoplasms is not fully understood. The objective of this study was to identify genetic markers and pathways specific to precancerous duodenal adenomas and early stage adenocarcinomas through gene expression analysis. METHODS: Gene expression profiling was performed in 4 pairs of duodenal adenoma/adenocarcinomas and corresponding matched normal tissue. Genes with consistent expression differences were identified and confirmed in 7 independent pairs...
June 28, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29951926/clinical-guidelines-for-primary-sclerosing-cholangitis-2017
#8
REVIEW
Hiroyuki Isayama, Susumu Tazuma, Norihiro Kokudo, Atsushi Tanaka, Toshio Tsuyuguchi, Takahiro Nakazawa, Kenji Notohara, Suguru Mizuno, Nobuhisa Akamatsu, Masahiro Serikawa, Itaru Naitoh, Yoshiki Hirooka, Toshifumi Wakai, Takao Itoi, Tomoki Ebata, Shinji Okaniwa, Terumi Kamisawa, Hiroki Kawashima, Atsushi Kanno, Keiichi Kubota, Masami Tabata, Michiaki Unno, Hajime Takikawa
BACKGROUND: Primary sclerosing cholangitis (PSC) is relatively rare disease and pathogenesis and methods of treatments were still not established. Then, we had conducted the making clinical guidelines to manage patients with PSC based on the literature review and expert opinions. These clinical guidelines were made for the medical doctors on the management of PSC, except child case of PSC. METHODS: We had employed modified Delphi method. The production committee decided guidelines, strength of recommendations and evidence level after reviewed literatures systematically, and The Expert panel evaluated those...
June 27, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29943163/efficacy-of-vonoprazan-in-prevention-of-bleeding-from-endoscopic-submucosal-dissection-induced-gastric-ulcers-a-prospective-randomized-phase-ii-study
#9
Kenta Hamada, Noriya Uedo, Yusuke Tonai, Masamichi Arao, Sho Suzuki, Taro Iwatsubo, Minoru Kato, Satoki Shichijo, Yasushi Yamasaki, Noriko Matsuura, Hiroko Nakahira, Takashi Kanesaka, Sachiko Yamamoto, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Ryu Ishihara, Hiroyuki Okada, Hiroyasu Iishi, Keisuke Fukui, Toshio Shimokawa
BACKGROUND: Vonoprazan, potassium-competitive acid blocker, is expected to reduce incidence of delayed bleeding after gastric endoscopic submucosal dissection (ESD); however, preliminary data to design a large-scale comparative study are lacking. This study aimed to assess the efficacy of vonoprazan in preventing delayed bleeding after gastric ESD. METHODS: In this single-center randomized phase II trial, a modified screened selection design was used with a threshold non-bleeding rate of 89% and an expected rate of 97%...
June 25, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29926167/differences-in-gut-microbiota-associated-with-age-sex-and-stool-consistency-in-healthy-japanese-subjects
#10
Tomohisa Takagi, Yuji Naito, Ryo Inoue, Saori Kashiwagi, Kazuhiko Uchiyama, Katsura Mizushima, Saeko Tsuchiya, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Kayo Okuda, Yoshimasa Tsujimoto, Hiromu Ohnogi, Yoshito Itoh
BACKGROUND: Human gut microbiota is involved in host health and disease development. Investigations of age-related and sex-related alterations in gut microbiota are limited, and the association between stool consistency and gut microbiota has not been fully investigated. We investigated gut microbiota differences related to age, sex, and stool consistency in healthy Japanese subjects. METHODS: Two-hundred and seventy-seven healthy Japanese subjects aged 20-89 years were enrolled...
June 20, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29923122/nudt15-codon-139-is-the-best-pharmacogenetic-marker-for-predicting-thiopurine-induced-severe-adverse-events-in-japanese-patients-with-inflammatory-bowel-disease-a-multicenter-study
#11
Yoichi Kakuta, Yosuke Kawai, Daisuke Okamoto, Tetsuya Takagawa, Kentaro Ikeya, Hirotake Sakuraba, Atsushi Nishida, Shoko Nakagawa, Miki Miura, Takahiko Toyonaga, Kei Onodera, Masaru Shinozaki, Yoh Ishiguro, Shinta Mizuno, Masahiro Takahara, Shunichi Yanai, Ryota Hokari, Tomoo Nakagawa, Hiroshi Araki, Satoshi Motoya, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Katsuya Endo, Taku Kobayashi, Makoto Naganuma, Sakiko Hiraoka, Takayuki Matsumoto, Shiro Nakamura, Hiroshi Nakase, Tadakazu Hisamatsu, Makoto Sasaki, Hiroyuki Hanai, Akira Andoh, Masao Nagasaki, Yoshitaka Kinouchi, Tooru Shimosegawa, Atsushi Masamune, Yasuo Suzuki
BACKGROUND: Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs. To clarify the best pharmacogenetic test to be used clinically, we performed association studies of NUDT15 variants and haplotypes with AEs, genome-wide association study (GWAS) to discover additional variants, and ROC analysis to select the model to predict severe AEs...
June 19, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29948305/increase-in-the-skeletal-muscle-mass-to-body-fat-mass-ratio-predicts-the-decline-in-transaminase-in-patients-with-nonalcoholic-fatty-liver-disease
#12
Naoki Mizuno, Yuya Seko, Seita Kataoka, Keiichiroh Okuda, Mitsuhiro Furuta, Masashi Takemura, Hiroyoshi Taketani, Tasuku Hara, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Yoshito Itoh
BACKGROUND: The aim of this retrospective study was to determine the effect of skeletal muscle and body fat on liver function in patients with nonalcoholic fatty liver disease (NAFLD) diagnosed by liver biopsy. METHODS: Among the 219 patients with NAFLD enrolled in this study was a cohort of 139 patients who had their body composition measured with Inbody720 at baseline and at ≥ 1 year postbaseline, to elucidate the relationship between liver function and changes in skeletal muscle and body fat mass...
June 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29948304/a-case-control-study-of-the-risk-of-upper-gastrointestinal-mucosal-injuries-in-patients-prescribed-concurrent-nsaids-and-antithrombotic-drugs-based-on-data-from-the-japanese-national-claims-database-of-13-million-accumulated-patients
#13
Nobuyuki Sugisaki, Ryuichi Iwakiri, Nanae Tsuruoka, Yasuhisa Sakata, Ryo Shimoda, Shun Fujimoto, Yuichiro Eguchi, Kazuma Fujimoto
BACKGROUND: We aimed to identify the adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and antithrombotics on the upper gastrointestinal (GI) mucosa in a clinical setting as a case-control study using a large-scale medical database in Japan. METHODS: We evaluated the risk of upper GI mucosal injuries in patients receiving NSAIDs and antithrombotics using the Japan Medical Data Center claims database with data for 13 million accumulated patients, from January 2009 to December 2014...
June 12, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29948303/surface-microstructures-are-associated-with-mutational-intratumoral-heterogeneity-in-colorectal-tumors
#14
Taku Harada, Eiichiro Yamamoto, Hiro-O Yamano, Hironori Aoki, Hiro-O Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Yoshihito Tanaka, Yuko Yoshida, Makoto Eizuka, Akira Yorozu, Gota Sudo, Hiroshi Kitajima, Takeshi Niinuma, Masahiro Kai, Yasushi Sasaki, Takashi Tokino, Tamotsu Sugai, Hiroshi Nakase, Hiromu Suzuki
BACKGROUND: Recent studies revealed that colorectal tumors are composed of genetically diverse subclones. We aimed to clarify whether the surface microstructures of colorectal tumors are associated with genetic intratumoral heterogeneity (ITH). METHODS: The surface microstructures (pit patterns) of colorectal tumors were observed using magnifying endoscopy, and biopsy specimens were obtained from respective areas when tumors exhibited multiple pit patterns. A total of 711 specimens from 477 colorectal tumors were analyzed for BRAF, KRAS and TP53 mutations using pyrosequencing and direct sequencing...
June 11, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29948302/crohn-s-disease-specific-mortality-a-30-year-cohort-study-at-a-tertiary-referral-center-in-japan
#15
Shigeyoshi Yasukawa, Toshiyuki Matsui, Yutaka Yano, Yuho Sato, Yasumichi Takada, Masahiro Kishi, Yoichiro Ono, Noritaka Takatsu, Takashi Nagahama, Takashi Hisabe, Fumihito Hirai, Kenshi Yao, Toshiharu Ueki, Daijiro Higashi, Kitaro Futami, Suketo Sou, Toshihiro Sakurai, Tsuneyoshi Yao, Hiroshi Tanabe, Akinori Iwashita, Masakazu Washio
BACKGROUND: In this study, survival and cause of death were investigated in patients with Crohn's disease (CD) at a tertiary referral center. METHODS: A database was created based on the medical records of 1108 CD patients who had a history of visiting our hospital to investigate background characteristics, cumulative survival rates from diagnosis, causes of death, and the standardized mortality ratio (SMR) for each cause of death. A follow-up questionnaire survey of patients followed up inadequately was also conducted...
June 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29869016/systematic-review-with-meta-analysis-real-world-effectiveness-and-safety-of-vedolizumab-in-patients-with-inflammatory-bowel-disease
#16
Stefan Schreiber, Axel Dignass, Laurent Peyrin-Biroulet, Greg Hather, Dirk Demuth, Mahmoud Mosli, Rebecca Curtis, Javaria Mona Khalid, Edward Vincent Loftus
BACKGROUND: Selective patient recruitment can produce discrepancies between clinical trial results and real-world effectiveness. METHODS: A systematic literature review and meta-analysis were conducted to assess vedolizumab real-world effectiveness and safety in patients with ulcerative colitis (UC) or Crohn's disease (CD). MEDLINE, MEDLINE In-Process, EMBASE, and Cochrane databases were searched for real-world studies of vedolizumab in adult patients with UC/CD reporting clinical response, remission, corticosteroid-free remission, UC/CD-related surgery or hospitalization, mucosal healing, or safety published from May 1, 2014-June 22, 2017...
June 4, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29802457/correction-to-the-novel-cutoff-points-for-the-fib4-index-categorized-by-age-increase-the-diagnostic-accuracy-in-nafld-a-multi-center-study
#17
Hiroshi Ishiba, Yoshio Sumida, Saiyu Tanaka, Masato Yoneda, Hideyuki Hyogo, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Masashi Yoneda, Hirokazu Takahashi, Takashi Nakahara, Yuya Seko, Kojiro Mori, Kazuyuki Kanemasa, Keiji Shimada, Sunsuke Imai, Kento Imajo, Takumi Kawaguchi, Atsushi Nakajima, Kazuaki Chayama, Toshiji Saibara, Toshihide Shima, Kazuma Fujimoto, Takeshi Okanoue, Yoshito Itoh
The coauthor Masashi Yoneda's affiliation has been incorrectly published in the original publication of the article. The correct affiliation is provided in this correction.
May 25, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29766276/anti-ganglionic-achr-antibodies-in-japanese-patients-with-motility-disorders
#18
Akihiro Mukaino, Hitomi Minami, Hajime Isomoto, Hitomi Hamamoto, Eikichi Ihara, Yasuhiro Maeda, Osamu Higuchi, Tohru Okanishi, Yohei Kokudo, Kazushi Deguchi, Fumisato Sasaki, Toshihito Ueki, Ken-Ya Murata, Takeshi Yoshida, Mistuyo Kinjo, Yoshihiro Ogawa, Akio Ido, Hidenori Matsuo, Kazuhiko Nakao, Shunya Nakane
BACKGROUND: The existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO)...
May 15, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29761234/prevalence-and-predictors-of-small-intestinal-bacterial-overgrowth-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#19
REVIEW
Binrui Chen, John Jae-Woo Kim, Yawen Zhang, Lijun Du, Ning Dai
BACKGROUND: The reported prevalence of small intestinal bacterial overgrowth (SIBO) among individuals with irritable bowel syndrome (IBS) is highly variable. The aim of the study is to estimate the prevalence and identify predictors of SIBO in IBS. METHODS: PubMed, Cochrane Library, and EMBASE through July 2017 were searched to identify studies evaluating the prevalence of SIBO in IBS. The pooled prevalence of SIBO among individuals with IBS and the pooled odds ratio (OR) of SIBO among those with IBS compared with healthy controls were calculated...
May 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29761233/liver-transplantation-japanese-contributions
#20
EDITORIAL
Susumu Eguchi, Taizo Hibi, Hiroto Egawa
No abstract text is available yet for this article.
May 14, 2018: Journal of Gastroenterology
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