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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/30219994/capsule-endoscopy-findings-for-the-diagnosis-of-crohn-s-disease-a-nationwide-case-control-study
#1
Motohiro Esaki, Takayuki Matsumoto, Naoki Ohmiya, Ema Washio, Toshifumi Morishita, Kei Sakamoto, Hiroo Abe, Shojiro Yamamoto, Tetsu Kinjo, Kazutomo Togashi, Kenji Watanabe, Fumihito Hirai, Masanao Nakamura, Sadaharu Nouda, Shinya Ashizuka, Teppei Omori, Shuji Kochi, Shunichi Yanai, Yuta Fuyuno, Atsushi Hirano, Junji Umeno, Takanari Kitazono, Fukunori Kinjo, Mamoru Watanabe, Toshiyuki Matsui, Yasuo Suzuki
BACKGROUND: Capsule endoscopy can be used to identify the early stage of small bowel Crohn's disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. METHODS: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD...
September 15, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30203225/efficacy-and-safety-of-sofosbuvir-velpatasvir-with-or-without-ribavirin-in-hcv-infected-japanese-patients-with-decompensated-cirrhosis-an-open-label-phase-3-trial
#2
Tetsuo Takehara, Naoya Sakamoto, Shuhei Nishiguchi, Fusao Ikeda, Tomohide Tatsumi, Yoshiyuki Ueno, Hiroshi Yatsuhashi, Yasuhiro Takikawa, Tatsuo Kanda, Minoru Sakamoto, Akihiro Tamori, Eiji Mita, Kazuaki Chayama, Gulan Zhang, Shampa De-Oertel, Hadas Dvory-Sobol, Takuma Matsuda, Luisa M Stamm, Diana M Brainard, Yasuhito Tanaka, Masayuki Kurosaki
BACKGROUND: In Japan, hepatitis C virus (HCV)-infected patients with decompensated cirrhosis currently have no treatment options. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir with or without ribavirin for 12 weeks in patients with any HCV genotype and decompensated cirrhosis [Child-Pugh-Turcotte (CPT) class B or C] in Japan. METHODS: Patients were randomized 1:1 to receive sofosbuvir-velpatasvir with or without ribavirin for 12 weeks. Randomization was stratified by CPT class and genotype...
September 10, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30191312/correction-to-differences-in-gut-microbiota-associated-with-age-sex-and-stool-consistency-in-healthy-japanese-subjects
#3
Tomohisa Takagi, Yuji Naito, Ryo Inoue, Saori Kashiwagi, Kazuhiko Uchiyama, Katsura Mizushima, Saeko Tsuchiya, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Kayo Okuda, Yoshimasa Tsujimoto, Hiromu Ohnogi, Yoshito Itoh
The authors would like to correct the errors in the publication of the original article. The correction details are given below for your reading.
September 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30182219/a-single-arm-phase-ii-trial-of-neoadjuvant-gemcitabine-and-s1-in-patients-with-resectable-and-borderline-resectable-pancreatic-adenocarcinoma-prep-01-study
#4
Fuyuhiko Motoi, Sohei Satoi, Goro Honda, Keita Wada, Hiroyuki Shinchi, Ippei Matsumoto, Masayuki Sho, Akihiko Tsuchida, Michiaki Unno
BACKGROUND: Neoadjuvant chemotherapy (NAC) represents a promising alternative to pancreatic ductal adenocarcinoma (PDAC) planned resection, but the survival impact remains undefined. To assess the feasibility and survival outcomes of NAC with gemcitabine and S1 (GS) for PDAC planned resection by prospective study. METHODS: Patients with resectable or borderline resectable PDAC received 2 cycles of NAC-GS and were offered curative resection followed by gemcitabine adjuvant...
September 4, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30167884/bowel-wall-healing-assessed-using-magnetic-resonance-imaging-predicts-sustained-clinical-remission-and-decreased-risk-of-surgery-in-crohn-s-disease
#5
Anthony Buisson, Constance Hordonneau, Felix Goutorbe, Christophe Allimant, Marion Goutte, Maud Reymond, Bruno Pereira, Gilles Bommelaer
BACKGROUND: Endoscopic mucosal healing is considered as the best therapeutic target in Crohn's disease (CD) as it is associated with better long-term outcomes. We investigated whether bowel wall healing (BWH) assessed using magnetic resonance imaging (MRI) could predict favorable outcomes and could be a potential therapeutic target. METHODS: We performed a post hoc analysis from two prospective studies (n = 174 patients). All the patients with previous objective signs of bowel inflammation and assessed by MRI for therapeutic efficacy had a standardized and blinded evaluation, and underwent MRI...
August 30, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30140950/adhesion-molecules-and-pancreatitis
#6
REVIEW
Takeshi Sato, Wataru Shibata, Shin Maeda
Acute and chronic pancreatitises are gastrointestinal inflammatory diseases, the incidence of which is increasing worldwide. Most (~ 80%) acute pancreatitis (AP) patients have mild disease, and about 20% have severe disease, which causes multiple organ failure and has a high mortality rate. Chronic pancreatitis (CP) is characterized by chronic inflammation and destruction of normal pancreatic parenchyma, which leads to loss of exocrine and endocrine tissues. Patients with CP also have a higher incidence of pancreatic ductal adenocarcinoma...
August 23, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30136216/long-term-outcome-of-entecavir-treatment-of-nucleos-t-ide-analogue-na%C3%A3-ve-chronic-hepatitis-b-patients-in-japan
#7
Fumitaka Suzuki, Tetsuya Hosaka, Yoshiyuki Suzuki, Hitomi Sezaki, Norio Akuta, Shunichiro Fujiyama, Yusuke Kawamura, Masahiro Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Rie Mineta, Yukiko Suzuki, Hiromitsu Kumada
BACKGROUND: We determined the antiviral potency and viral breakthrough rate after 10 years of continuous entecavir treatment in patients with chronic hepatitis B (CHB) infection. METHODS: The cumulative rates of undetectable hepatitis B virus DNA (HBV-DNA, < 2.1 log copies/mL), alanine aminotransferase (ALT) normalization, hepatitis B e antigen (HBeAg) seroclearance, hepatitis B surface antigen (HBsAg) seroclearance, and viral breakthrough of 1094 nucleos(t)ide analogue-naïve CHB patients (HBeAg-positive: 47%) who were on continuous entecavir treatment for 10 years were calculated...
August 22, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30109418/development-and-validation-of-a-web-based-questionnaire-to-identify-environmental-risk-factors-for-inflammatory-bowel-disease-the-groningen-ibd-environmental-questionnaire-gieq
#8
Kimberley Wilhelmina Johanna van der Sloot, Rinse Karel Weersma, Gerard Dijkstra, Behrooz Zaid Alizadeh
BACKGROUND: In the complex etiology of inflammatory bowel disease (IBD), the exposome is a major contributor. Though many environmental exposures have been identified, quality of evidence varies greatly and overall evidence for the exposome is inconclusive. A universal, precise, and reproducible measurement tool is needed to study the exposome in IBD. METHODS: We built the web-based Groningen IBD Environmental Questionnaire (GIEQ), an extensive and structured questionnaire measuring potentially involved environmental exposures, consisting of 848 items, subdivided into 15 categories...
August 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30105510/a-randomized-controlled-trial-of-lusutrombopag-in-japanese-patients-with-chronic-liver-disease-undergoing-radiofrequency-ablation
#9
Ryosuke Tateishi, Masataka Seike, Masatoshi Kudo, Hideyuki Tamai, Seiji Kawazoe, Takayuki Katsube, Toshimitsu Ochiai, Takahiro Fukuhara, Takeshi Kano, Katsuaki Tanaka, Mineo Kurokawa, Kazuhide Yamamoto, Yukio Osaki, Namiki Izumi, Michio Imawari
BACKGROUND: Thrombocytopenia represents an obstacle for invasive procedures in chronic liver disease (CLD) patients. We aimed to estimate the appropriate dose and evaluate the efficacy and safety of lusutrombopag for the treatment of thrombocytopenia before percutaneous liver radiofrequency ablation (RFA) for primary hepatic cancer in patients with CLD. METHODS: In this multicenter, randomized, double-blind, placebo-controlled study conducted in Japan, 61 CLD patients with platelet count < 50 × 103 /µL at screening were randomized to placebo or lusutrombopag 2, 3, or 4 mg once daily for 7 days, followed by a 28-day post-treatment assessment period...
August 13, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30101408/epithelial-stromal-crosstalk-and-fibrosis-in-eosinophilic-esophagitis
#10
REVIEW
Amanda B Muir, Joshua X Wang, Hiroshi Nakagawa
Eosinophilic esophagitis (EoE) is a food allergen-induced inflammatory disorder. EoE is increasingly recognized as a cause of swallowing dysfunction, food impaction and esophageal stricture. Inflammation of the esophageal mucosa involves immune cell infiltrate, reactive epithelial changes and fibroblast activation, culminating in robust tissue remodeling toward esophageal fibrosis characterized by excess collagen deposition in the subepithelial lamina propria. Fibrosis contributes to a unique mechanical property of the EoE-affected esophagus that is substantially stiffer than the normal esophagus...
August 12, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30056494/reply-to-sarcopenia-definition-in-patients-with-nafld
#11
LETTER
Yuya Seko
No abstract text is available yet for this article.
July 28, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30043173/sarcopenia-definition-in-patients-with-nafld
#12
LETTER
Tao-Chun Peng
No abstract text is available yet for this article.
July 24, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30019127/safety-and-efficacy-of-elbasvir-and-grazoprevir-in-japanese-hemodialysis-patients-with-genotype-1b-hepatitis-c-virus-infection
#13
Goki Suda, Masayuki Kurosaki, Jun Itakura, Namiki Izumi, Yoshihito Uchida, Satoshi Mochida, Chitomi Hasebe, Masami Abe, Hiroaki Haga, Yoshiyuki Ueno, Ikuto Masakane, Kazumichi Abe, Atsushi Takahashi, Hiromasa Ohira, Ken Furuya, Masaru Baba, Yoshiya Yamamoto, Tomoe Kobayashi, Atsuhiko Kawakami, Kenichi Kumagai, Katsumi Terasita, Masatsugu Ohara, Naoki Kawagishi, Machiko Umemura, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
BACKGROUND: The prevalence of hepatitis C virus (HCV) infection in hemodialysis patients is high and results in a poor prognosis. Thus, safer and more effective treatment regimens are required. In this prospective multicenter study, we investigated the efficacy and safety of the novel HCV-NS5A-inhibitor, elbasvir, and protease inhibitor, grazoprevir in Japanese hemodialysis patients with genotype 1b HCV infection. METHODS: This study is registered at the UMIN Clinical Trials Registry as UMIN00002578...
July 17, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30006904/hepatocellular-carcinoma-as-a-leading-cause-of-cancer-related-deaths-in-japanese-type-2-diabetes-mellitus-patients
#14
Toshihide Shima, Hirofumi Uto, Kohjiro Ueki, Yutaka Kohgo, Kohichiroh Yasui, Naoto Nakamura, Tatsuaki Nakatou, Toshinari Takamura, Sumio Kawata, Kazuo Notsumata, Kyoko Sakai, Ryosuke Tateishi, Takeshi Okanoue
BACKGROUND: We reported a cross-sectional study on causes of liver injury in Japanese type 2 diabetes mellitus (T2D) patients (JG 2013). We assessed overall and cause-specific mortality risk during follow-up of patients enrolled in JG 2013. METHODS: This was a longitudinal, multicenter cohort study. Of the 5642 Japanese T2D patients who visited T2D clinics of nine hospitals in the original study, 3,999 patients were followed up for an average of 4.5 years. Expected deaths in T2D patients were estimated using age-specific mortality rates in the general population (GP) of Japan...
July 13, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30003334/microbial-biomarkers-for-immune-checkpoint-blockade-therapy-against-cancer
#15
REVIEW
Keishi Adachi, Koji Tamada
Three major standard treatments, i.e., surgery, chemotherapy, and radiotherapy, were traditionally applied to the treatment of cancer and saved many patients. Meanwhile, clinical studies as well as basic research of immunotherapy are being actively conducted for intractable or advanced malignancies that cannot be cured by the conventional standard treatments. Remarkable therapeutic efficacies have been recently reported in clinical trials on some cancer types, and immunotherapy is now being recognized as the "fourth" standard therapy against cancer...
July 12, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29980847/the-real-world-efficacy-and-safety-of-daas-for-the-treatment-of-hcv-patients-throughout-japan
#16
EDITORIAL
Shinya Maekawa, Nobuyuki Enomoto
No abstract text is available yet for this article.
July 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29971498/a-genetic-variant-located-in-the-mir-532-5p-binding-site-of-tgfbr1-is-associated-with-the-colorectal-cancer-risk
#17
Dongying Gu, Shuwei Li, Mulong Du, Cuiju Tang, Haiyan Chu, Na Tong, Zhengdong Zhang, Meilin Wang, Jinfei Chen
BACKGROUND: Genome-wide association studies have identified genes in the transforming growth factor-β (TGFβ) signaling pathway that are responsible for regulating carcinogenesis. METHODS: We searched for single-nucleotide polymorphisms (SNPs) located within 3'-untranslated regions (3'-UTRs) that might affect the ability of miRNAs to bind genes in the TGFβ pathway for further analysis. We used TaqMan technology to genotype these SNPs in a population-based case-control study of 1147 colorectal cancer patients and 1203 matched controls in a Chinese population...
July 3, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29961130/endoscopic-diagnosis-and-treatment-of-esophageal-adenocarcinoma-introduction-of-japan-esophageal-society-classification-of-barrett-s-esophagus
#18
REVIEW
Ryu Ishihara, Kenichi Goda, Tsuneo Oyama
Endoscopic surveillance of Barrett's esophagus has become a foundation of the management of esophageal adenocarcinoma (EAC). Surveillance for Barrett's esophagus commonly involves periodic upper endoscopy with biopsies of suspicious areas and random four-quadrant biopsies. However, targeted biopsies using narrow-band imaging can detect more dysplastic areas and thus reduce the number of biopsies required. Several specific mucosal and vascular patterns characteristic of Barrett's esophagus have been described, but the proposed criteria are complex and diverse...
June 30, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29951927/identification-of-marker-genes-and-pathways-specific-to-precancerous-duodenal-adenomas-and-early-stage-adenocarcinomas
#19
Yoshiki Sakaguchi, Nobutake Yamamichi, Shuta Tomida, Chihiro Takeuchi, Natsuko Kageyama-Yahara, Yu Takahashi, Kazuya Shiogama, Ken-Ichi Inada, Masao Ichinose, Mitsuhiro Fujishiro, Kazuhiko Koike
BACKGROUND: The mechanism behind the pathogenesis and carcinogenesis of these neoplasms is not fully understood. The objective of this study was to identify genetic markers and pathways specific to precancerous duodenal adenomas and early stage adenocarcinomas through gene expression analysis. METHODS: Gene expression profiling was performed in 4 pairs of duodenal adenoma/adenocarcinomas and corresponding matched normal tissue. Genes with consistent expression differences were identified and confirmed in 7 independent pairs...
June 28, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29943163/efficacy-of-vonoprazan-in-prevention-of-bleeding-from-endoscopic-submucosal-dissection-induced-gastric-ulcers-a-prospective-randomized-phase-ii-study
#20
Kenta Hamada, Noriya Uedo, Yusuke Tonai, Masamichi Arao, Sho Suzuki, Taro Iwatsubo, Minoru Kato, Satoki Shichijo, Yasushi Yamasaki, Noriko Matsuura, Hiroko Nakahira, Takashi Kanesaka, Sachiko Yamamoto, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Ryu Ishihara, Hiroyuki Okada, Hiroyasu Iishi, Keisuke Fukui, Toshio Shimokawa
BACKGROUND: Vonoprazan, potassium-competitive acid blocker, is expected to reduce incidence of delayed bleeding after gastric endoscopic submucosal dissection (ESD); however, preliminary data to design a large-scale comparative study are lacking. This study aimed to assess the efficacy of vonoprazan in preventing delayed bleeding after gastric ESD. METHODS: In this single-center randomized phase II trial, a modified screened selection design was used with a threshold non-bleeding rate of 89% and an expected rate of 97%...
June 25, 2018: Journal of Gastroenterology
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