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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/29766276/anti-ganglionic-achr-antibodies-in-japanese-patients-with-motility-disorders
#1
Akihiro Mukaino, Hitomi Minami, Hajime Isomoto, Hitomi Hamamoto, Eikichi Ihara, Yasuhiro Maeda, Osamu Higuchi, Tohru Okanishi, Yohei Kokudo, Kazushi Deguchi, Fumisato Sasaki, Toshihito Ueki, Ken-Ya Murata, Takeshi Yoshida, Mistuyo Kinjo, Yoshihiro Ogawa, Akio Ido, Hidenori Matsuo, Kazuhiko Nakao, Shunya Nakane
BACKGROUND: The existence of several autoantibodies suggests an autoimmune basis for gastrointestinal (GI) dysmotility. Whether GI motility disorders are features of autoimmune autonomic ganglionopathy (AAG) or are related to circulating anti-ganglionic acetylcholine receptor (gAChR) antibodies (Abs) is not known. The aim of this study was to determine the associations between autonomic dysfunction, anti-gAChR Abs, and clinical features in patients with GI motility disorders including achalasia and chronic intestinal pseudo-obstruction (CIPO)...
May 15, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29761234/prevalence-and-predictors-of-small-intestinal-bacterial-overgrowth-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#2
REVIEW
Binrui Chen, John Jae-Woo Kim, Yawen Zhang, Lijun Du, Ning Dai
BACKGROUND: The reported prevalence of small intestinal bacterial overgrowth (SIBO) among individuals with irritable bowel syndrome (IBS) is highly variable. The aim of the study is to estimate the prevalence and identify predictors of SIBO in IBS. METHODS: PubMed, Cochrane Library, and EMBASE through July 2017 were searched to identify studies evaluating the prevalence of SIBO in IBS. The pooled prevalence of SIBO among individuals with IBS and the pooled odds ratio (OR) of SIBO among those with IBS compared with healthy controls were calculated...
May 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29761233/liver-transplantation-japanese-contributions
#3
EDITORIAL
Susumu Eguchi, Taizo Hibi, Hiroto Egawa
No abstract text is available yet for this article.
May 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29754314/response-to-the-letter-by-dr-tomoyuki-kawada-regarding-our-manuscript-independent-association-between-prediabetes-and-future-pancreatic-fat-accumulation-a-5-year-japanese-cohort-study
#4
LETTER
Hajime Yamazaki, Shinichi Tauchi, Miho Kimachi, Mitsuru Dohke, Nagisa Hanawa, Yoshihisa Kodama, Akio Katanuma, Yosuke Yamamoto, Shunichi Fukuhara, Shingo Fukuma
No abstract text is available yet for this article.
May 12, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29754313/prediabetes-and-subsequent-pancreatic-fat-accumulation
#5
LETTER
Tomoyuki Kawada
No abstract text is available yet for this article.
May 12, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29749571/hepatic-irs1-and-%C3%A3-catenin-expression-is-associated-with-histological-progression-and-overt-diabetes-emergence-in-nafld-patients
#6
Kenichiro Enooku, Mayuko Kondo, Naoto Fujiwara, Takayoshi Sasako, Junji Shibahara, Akira Kado, Kazuya Okushin, Hidetaka Fujinaga, Takeya Tsutsumi, Ryo Nakagomi, Tatsuya Minami, Masaya Sato, Hayato Nakagawa, Yuji Kondo, Yoshinari Asaoka, Ryosuke Tateishi, Kohjiro Ueki, Hitoshi Ikeda, Haruhiko Yoshida, Kyoji Moriya, Hiroshi Yotsuyanagi, Takashi Kadowaki, Masashi Fukayama, Kazuhiko Koike
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes. Our aim was to investigate the relationship between NAFLD and impaired glucose metabolism in terms of insulin receptor substrate 1 and 2 (IRS1 and IRS2) expression in the liver. METHODS: Liver biopsy was performed at the University of Tokyo Hospital between November 2011 and March 2016 on 146 patients with NAFLD who were not being treated with any diabetes or dyslipidemia drugs...
May 10, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29744597/the-novel-cutoff-points-for-the-fib4-index-categorized-by-age-increase-the-diagnostic-accuracy-in-nafld-a-multi-center-study
#7
Hiroshi Ishiba, Yoshio Sumida, Saiyu Tanaka, Masato Yoneda, Hideyuki Hyogo, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Masashi Yoneda, Hirokazu Takahashi, Takashi Nakahara, Yuya Seko, Kojiro Mori, Kazuyuki Kanemasa, Keiji Shimada, Sunsuke Imai, Kento Imajo, Takumi Kawaguchi, Atsushi Nakajima, Kazuaki Chayama, Toshiji Saibara, Toshihide Shima, Kazuma Fujimoto, Takeshi Okanoue, Yoshito Itoh
BACKGROUND: The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan. METHODS: The FIB4 index was determined in biopsy-confirmed NAFLD patients (n = 1050) who were divided into four groups: ≤ 49, 50-59, 60-69, and ≥ 70 years. ROC analysis predicted advanced fibrosis in each age group; low and high cutoff points were defined by a sensitivity and specificity of 90%...
May 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29740665/real-world-virological-efficacy-and-safety-of-elbasvir-and-grazoprevir-in-patients-with-chronic-hepatitis-c-virus-genotype-1-infection-in-japan
#8
Hidenori Toyoda, Masanori Atsukawa, Koichi Takaguchi, Tomonori Senoh, Kojiro Michitaka, Atsushi Hiraoka, Shinichi Fujioka, Chisa Kondo, Tomomi Okubo, Haruki Uojima, Toshifumi Tada, Hirohito Yoneyama, Tsunamasa Watanabe, Toru Asano, Toru Ishikawa, Hideyuki Tamai, Hiroshi Abe, Keizo Kato, Kunihiko Tsuji, Chikara Ogawa, Noritomo Shimada, Etsuko Iio, Akihiro Deguchi, Ei Itobayashi, Shigeru Mikami, Akio Moriya, Hironao Okubo, Joji Tani, Akihito Tsubota, Yasuhito Tanaka, Tsutomu Masaki, Katsuhiko Iwakiri, Takashi Kumada
BACKGROUND: The real-world virological efficacy and safety of an interferon (IFN)-free direct-acting antiviral (DAA) therapy with elbasvir (EBR) and grazoprevir (GZR) were evaluated in Japanese patients chronically infected with hepatitis C virus (HCV) genotype 1. METHODS: The rate of sustained virologic response (SVR) and safety were analyzed in patients who started the EBR/GZR regimen between November 2016 and July 2017. SVR rates were compared based on patient baseline characteristics...
May 8, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29721628/impact-of-tumor-localization-on-the-outcomes-of-surgery-for-an-intrahepatic-cholangiocarcinoma
#9
Tatsuya Orimo, Toshiya Kamiyama, Tomoko Mitsuhashi, Hirofumi Kamachi, Hideki Yokoo, Kenji Wakayama, Shingo Shimada, Akihisa Nagatsu, Akinobu Taketomi
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) shows differing clinical outcomes depending on its localization. METHODS: We reviewed the surgical outcomes of 104 ICC patients who underwent liver resection at our institution. We divided ICC into hilar type (HICC) and peripheral type (PICC) depending on positive contact with the hepatic hilum on preoperative computed tomography (CT). RESULTS: The survival outcomes were significantly poorer in HICC patients...
May 2, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29693194/response-to-the-letter-by-poddighe-et-al-regarding-our-manuscript-basophils-activated-via-tlr-signaling-may-contribute-to-pathophysiology-of-type-1-autoimmune-pancreatitis
#10
LETTER
Kazushige Uchida, Masato Ynagawa, Kazuichi Okazaki
No abstract text is available yet for this article.
April 24, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29680867/evaluation-of-ballooned-hepatocytes-as-a-risk-factor-for-future-progression-of-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#11
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Tamami Abe, Miki Yonezawa, Hidekatsu Kuroda, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
BACKGROUND: The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased. Non-alcoholic steatohepatitis (NASH) shows progression of liver fibrosis in NAFLD. It remains unclear which patients with NAFLD will show progression of liver fibrosis. Therefore, we aimed to investigate the risk factor associated with the progression of liver fibrosis among patients with NAFLD. METHODS: This observational study enrolled 157 patients with biopsy-proven NAFLD. Thirty-two patients were excluded because of lack of data...
April 21, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29675604/long-term-natural-history-of-liver-disease-in-patients-with-chronic-hepatitis-b-virus-infection-an-analysis-using-the-markov-chain-model
#12
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Masayuki Ohisa, Tomoyuki Akita, Junko Tanaka
BACKGROUND: The relationship between the hepatitis B e antigen (HBeAg) seroconversion and the long-term natural history of liver disease has not been sufficiently investigated. METHODS: A total of 408 [4352 person-year (PY) units] patients with chronic hepatitis B virus (HBV) without antiviral therapy were enrolled. The study patients were divided into three groups, as follows: Group A (2666 PY units), seroconverted of HBeAg at age < 40; Group B (413 PY units), seroconverted of HBeAg at age ≥ 40; Group C (1273 PY units), persistently HBeAg positive...
April 19, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29667044/germline-variants-in-pancreatic-cancer-patients-with-a-personal-or-family-history-of-cancer-fulfilling-the-revised-bethesda-guidelines
#13
Akihiro Ohmoto, Chigusa Morizane, Emi Kubo, Erina Takai, Hiroko Hosoi, Yasunari Sakamoto, Shunsuke Kondo, Hideki Ueno, Kazuaki Shimada, Shinichi Yachida, Takuji Okusaka
BACKGROUND: Pancreatic cancer (PC) is categorized as a neoplasm associated with Lynch syndrome; however, the precise proportion of PC patients harboring DNA mismatch repair genes (MMR genes) remains unclear, especially in the Asian population. METHODS: Among 304 Japanese patients with pathologically proven pancreatic ductal adenocarcinoma, we selected 20 (6.6%) patients with a personal or family history involving first- or second-degree relatives fulfilling the revised Bethesda guidelines (RBG), defined as RBG-compatible cases...
April 17, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29663078/basophils-activated-via-tlr-signaling-may-contribute-to-pathophysiology-of-type-i-autoimmune-pancreatitis
#14
LETTER
Dimitri Poddighe, Ilaria Brambilla, Gian Luigi Marseglia
No abstract text is available yet for this article.
April 16, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29663077/is-patient-reported-outcome-improved-by-nalfurafine-hydrochloride-in-patients-with-primary-biliary-cholangitis-and-refractory-pruritus-a-post-marketing-single-arm-prospective-study
#15
Minami Yagi, Atsushi Tanaka, Tadashi Namisaki, Atsushi Takahashi, Masanori Abe, Akira Honda, Yasushi Matsuzaki, Hiromasa Ohira, Hitoshi Yoshiji, Hajime Takikawa
BACKGROUND: Patients with primary biliary cholangitis (PBC) frequently suffer from pruritus, which can severely impair their health-related quality of life (HRQOL). Nalfurafine hydrochloride, a selective κ-opioid receptor agonist, was recently approved in Japan for refractory pruritus in patients with chronic liver diseases, but it still remains unclear whether this treatment improves the patient-reported outcome (PRO) in PBC patients with refractory pruritus. Herein, we conducted a multicenter, post-marketing, single-arm prospective study to investigate the efficacy of nalfurafine in terms of PRO, and the associations of the efficacy with any clinical characteristics...
April 16, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29633013/clinical-impact-of-intratumoral-her2-heterogeneity-on-trastuzumab-efficacy-in-patients-with-her2-positive-gastric-cancer
#16
Takeru Wakatsuki, Noriko Yamamoto, Takeshi Sano, Keisho Chin, Hiroshi Kawachi, Daisuke Takahari, Mariko Ogura, Takashi Ichimura, Izuma Nakayama, Hiroki Osumi, Tomohiro Matsushima, Mitsukuni Suenaga, Eiji Shinozaki, Naoki Hiki, Yuichi Ishikawa, Kensei Yamaguchi
BACKGROUND: There is growing interest in the clinical significance of intratumoral HER2 heterogeneity. Its prognostic and predictive impacts on trastuzumab efficacy were demonstrated in breast cancer. However, its clinical significance in gastric cancer is still unclear. METHODS: Twenty-eight HER2-positive gastric cancer patients who had gastrectomy prior to trastuzumab-based chemotherapy were consecutively enrolled. Intratumoral HER heterogeneity was evaluated using whole-tissue sections by immunohistochemistry...
April 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29626296/real-world-efficacy-and-safety-of-ledipasvir-and-sofosbuvir-in-patients-with-hepatitis-c-virus-genotype-1-infection-a-nationwide-multicenter-study-by-the-japanese-red-cross-liver-study-group
#17
Keiji Tsuji, Masayuki Kurosaki, Jun Itakura, Nami Mori, Shintaro Takaki, Chitomi Hasebe, Takehiro Akahane, Kouji Joko, Hitoshi Yagisawa, Jirou Takezawa, Ryou Nakata, Atsunori Kusakabe, Yuji Kojima, Hiroyuki Kimura, Takashi Tamada, Haruhiko Kobashi, Akeri Mitsuda, Masahiko Kondou, Chikara Ogawa, Yasushi Uchida, Tetsuro Sohda, Ryouichi Narita, Namiki Izumi
BACKGROUND: We aimed to describe the real-world efficacy and safety of combination therapy with ledipasvir and sofosbuvir (LDV/SOF) for chronic hepatitis C virus (HCV) genotype 1 (GT1) infection. METHODS: This retrospective analysis of a prospective, nationwide, multicenter registry included GT1-infected patients treated with LDV/SOF for 12 weeks. We assessed the rate of sustained virological response at 12 weeks post-treatment (SVR12), incidence of adverse events, and serum markers of hepatocellular carcinoma (HCC)...
April 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29623439/potential-clinical-application-of-strain-elastography-in-chronic-liver-diseases
#18
LETTER
Rui Huang, Jian Wang, Juan Xia, Yingying Hao, Chao Wu
No abstract text is available yet for this article.
April 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29623438/reply-to-letter-to-editor-submitted-by-rui-huang-et-al-entitled-potential-clinical-application-of-strain-elastography-in-chronic-liver-diseases
#19
LETTER
Kazuto Tajiri, Kengo Kawai, Toshiro Sugiyama
No abstract text is available yet for this article.
April 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29616332/author-s-reply-can-budesonide-form-be-alterative-treatment-for-ulcerative-proctosigmoiditis
#20
LETTER
Makoto Naganuma
No abstract text is available yet for this article.
April 3, 2018: Journal of Gastroenterology
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