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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/29318378/mac-2-binding-protein-glycan-isomer-m2bpgi-is-a-new-serum-biomarker-for-assessing-liver-fibrosis-more-than-a-biomarker-of-liver-fibrosis
#1
REVIEW
Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, Kenichiro Araki, Norihiro Ishii, Atsushi Kuno, Hisashi Narimatsu, Masashi Mizokami
Assessing liver fibrosis is important for predicting the efficacy of antiviral therapy and patient prognosis. Liver biopsy is the gold standard for diagnosing liver fibrosis, despite its invasiveness and problematic diagnostic accuracy. Although noninvasive techniques to assess liver fibrosis are becoming important, reliable serum surrogate markers are not available. A glycoproteomics study aimed at identifying such markers discovered Mac 2-Binding Protein Gylcan Isomer (M2BPGi), which is a reliable marker for assessing liver fibrosis in patients with viral hepatitis and other fibrotic liver diseases such as primary biliary cholangitis, biliary atresia, autoimmune hepatitis, and nonalcoholic fatty liver disease...
January 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29313109/clinical-features-of-chronic-enteropathy-associated-with-slco2a1-gene-a-new-entity-clinically-distinct-from-crohn-s-disease
#2
Junji Umeno, Motohiro Esaki, Atsushi Hirano, Yuta Fuyuno, Naoki Ohmiya, Shigeyoshi Yasukawa, Fumihito Hirai, Shuji Kochi, Koichi Kurahara, Shunichi Yanai, Keiichi Uchida, Shuhei Hosomi, Kenji Watanabe, Naoki Hosoe, Haruhiko Ogata, Tadakazu Hisamatsu, Manabu Nagayama, Hironori Yamamoto, Daiki Abukawa, Fumihiko Kakuta, Kei Onodera, Toshiyuki Matsui, Toshifumi Hibi, Tsuneyoshi Yao, Takanari Kitazono, Takayuki Matsumoto
BACKGROUND: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations in the SLCO2A1 gene and characterized by multiple small intestinal ulcers of nonspecific histology. SLCO2A1 is also a causal gene of primary hypertrophic osteoarthropathy (PHO). However, little is known about the clinical features of CEAS or PHO. METHODS: Sixty-five Japanese patients recruited by a nationwide survey of CEAS during 2012-2016 were enrolled in this present study...
January 8, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29305648/multicenter-observational-study-on-functional-bowel-disorders-diagnosed-using-rome-iii-diagnostic-criteria-in-japan
#3
Masayoshi Ono, Mototsugu Kato, Shuichi Miyamoto, Momoko Tsuda, Takeshi Mizushima, Shouko Ono, Manabu Nakagawa, Katsuhiro Mabe, Soichi Nakagawa, Shuichi Muto, Yuichi Shimizu, Mineo Kudo, Shinichi Katsuki, Takashi Meguro, Naoya Sakamoto
BACKGROUND: The Rome III diagnostic criteria had been used to diagnose functional gastrointestinal disorders (FGIDs) world wide, and functional bowel disorders (FBDs) including irritable bowel syndrome (IBS) have recently attracted the attention of Japanese physicians. However, there have been few reports on the prevalence of FBDs diagnosed by the Rome III diagnostic criteria. AIMS: The aim of this study was to determine the prevalence of FBDs diagnosed according to the diagnostic criteria of Rome III in Japan...
January 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29299684/treatment-of-hepatitis-c-in-special-populations
#4
REVIEW
Goki Suda, Koji Ogawa, Kenichi Morikawa, Naoya Sakamoto
Hepatitis C virus (HCV) infection is one of the primary causes of liver cirrhosis and hepatocellular carcinoma. In hemodialysis patients, the rate of HCV infection is high and is moreover associated with a poor prognosis. In liver transplantation patients with HCV infection, recurrent HCV infection is universal, and re-infected HCV causes rapid progression of liver fibrosis and graft loss. Additionally, in patients with HCV and human immunodeficiency virus (HIV) co-infection, liver fibrosis progresses rapidly...
January 3, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29288305/high-levels-of-serum-mac-2-binding-protein-glycosylation-isomer-m2bpgi-predict-the-development-of-hepatocellular-carcinoma-in-hepatitis-b-patients-treated-with-nucleot-s-ide-analogues
#5
Noboru Shinkai, Masanori Nojima, Etsuko Iio, Kayoko Matsunami, Hidenori Toyoda, Shuko Murakami, Takako Inoue, Shintaro Ogawa, Takashi Kumada, Yasuhito Tanaka
BACKGROUND: Nucleot(s)ide analogues (NA) can reduce the risk of hepatocellular carcinoma (HCC), but not completely prevent its development. METHODS: Two hundred and thirty-four chronic hepatitis B patients virologically well controlled with entecavir or tenofovir disoproxil fumarate for more than 1 year were enrolled in this study. Over the median observation period of 51 (12-142) months, 24 of 234 patients developed HCC. We quantified HBV markers, alpha-fetoprotein (AFP) and Mac-2-binding protein glycosylation isomer (M2BPGi) at baseline and 48 weeks after therapy...
December 29, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29260300/the-recovery-of-the-pt-inr-to-less-than-1-3-predicts-survival-in-patients-with-severe-acute-liver-injury
#6
Seiichi Mawatari, Akihiro Moriuchi, Fuminori Ohba, Tetsu Kawano, Kohei Oda, Yasuhiro Takikawa, Hajime Takikawa, Akio Ido, Hirohito Tsubouchi
BACKGROUND: Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to predict "survival" has not been extensively conducted. In this study, we investigate the medical history of patients in two distinct areas of Japan with the aim of identifying the predictors of survival in patients with acute liver injury (ALI)...
December 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29247356/current-and-future-pharmacological-therapies-for-nafld-nash
#7
REVIEW
Yoshio Sumida, Masashi Yoneda
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and there is no approved pharmacotherapy. The efficacy of vitamin E and pioglitazone has been established in nonalcoholic steatohepatitis (NASH), a progressive form of NAFLD. GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have beneficial cardiovascular or renal effects. Innovative NASH therapies include four main pathways. The first approach is targeting hepatic fat accumulation...
December 16, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29238877/cryptogenic-cholestasis-in-young-and-adults-atp8b1-abcb11-abcb4-and-tjp2-gene-variants-analysis-by-high-throughput-sequencing
#8
Giovanni Vitale, Stefano Gitto, Francesco Raimondi, Alessandro Mattiaccio, Vilma Mantovani, Ranka Vukotic, Antonietta D'Errico, Marco Seri, Robert B Russell, Pietro Andreone
BACKGROUND: Mutations in ATP-transporters ATPB81, ABCB11, and ABCB4 are responsible for progressive familial intrahepatic cholestasis (PFIC) 1, 2 and 3, and recently the gene for tight junction protein-2 (TJP2) has been linked to PFIC4. AIM: As these four genes have been poorly studied in young people and adults, we investigated them in this context here. METHODS: In patients with cryptogenic cholestasis, we analyzed the presence of mutations by high-throughput sequencing...
December 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29238876/independent-association-between-prediabetes-and-future-pancreatic-fat-accumulation-a-5-year-japanese-cohort-study
#9
Hajime Yamazaki, Shinichi Tauchi, Miho Kimachi, Mitsuru Dohke, Nagisa Hanawa, Yoshihisa Kodama, Akio Katanuma, Yosuke Yamamoto, Shunichi Fukuhara, Shingo Fukuma
BACKGROUND: The association between pancreatic fat and glucose dysmetabolism has been reported in several cross-sectional studies; however, a recent longitudinal study showed that baseline pancreatic fat did not cause subsequent diabetes mellitus. We hypothesized that pancreatic fat is not a cause but a manifestation of glucose dysmetabolism and aimed to investigate the association between baseline prediabetes and future pancreatic fat accumulation. METHODS: Between 2008 and 2015, 198 nondiabetic participants, who underwent a health check-up via unenhanced computed tomography (CT) twice with CT intervals ≥ 5 years, were enrolled as prediabetes (n = 48) and non-prediabetes participants (n = 150)...
December 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29222587/gastrointestinal-manifestation-of-immunoglobulin-g4-related-disease-clarification-through-a-multicenter-survey
#10
Kenji Notohara, Terumi Kamisawa, Kazushige Uchida, Yoh Zen, Mitsuhiro Kawano, Satomi Kasashima, Yasuharu Sato, Masahiro Shiokawa, Takeshi Uehara, Hajime Yoshifuji, Hiroko Hayashi, Koichi Inoue, Keisuke Iwasaki, Hiroo Kawano, Hiroyuki Matsubayashi, Yukitoshi Moritani, Katsuhiko Murakawa, Yoshio Oka, Masatoshi Tateno, Kazuichi Okazaki, Tsutomu Chiba
BACKGROUND: Several reports on immunoglobulin (Ig)G4-related disease (IgG4-RD) with gastrointestinal involvement (IgG4-related gastrointestinal disease; IgG4-GID) have been published, although this entity has not been fully established clinicopathologically. Thus, we carried out a multicenter survey. METHODS: Patients with possible IgG4-GID who underwent resection were collected. Histologic slides were reevaluated, and eight cases with diffuse lymphoplasmacytic infiltration but without numerous neutrophils, granulations or epithelioid granulomas were further analyzed...
December 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29209839/correction-to-telomere-length-of-gallbladder-epithelium-is-shortened-in-patients-with-congenital-biliary-dilatation-measurement-by-quantitative-fluorescence-in-situ-hybridization
#11
Yuto Aoki, Junko Aida, Youichi Kawano, Ken-Ichi Nakamura, Naotaka Izumiyama-Shimomura, Naoshi Ishikawa, Tomio Arai, Yoshiharu Nakamura, Nobuhiko Taniai, Eiji Uchida, Kaiyo Takubo, Toshiyuki Ishiwata
In the original publication of this article, Fig. 5 was published with incorrect color of the approximate lines of CBD and Control.
December 5, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29192348/a-nationwide-population-based-study-of-common-bile-duct-stone-recurrence-after-endoscopic-stone-removal-in-korea
#12
Byung Kyu Park, Jeong Hun Seo, Han Ho Jeon, Jong Won Choi, Sun Young Won, Yong Suk Cho, Chun Kyon Lee, Haeyong Park, Dong Wook Kim
BACKGROUND: There is no consensus whether patients who underwent endoscopic common bile duct (CBD) stone removal should be followed up periodically and whether patients with gallbladder (GB) stones should undergo cholecystectomy. Thus, this study aimed to investigate the recurrence rate of CBD stones and the difference in recurrence rate according to cholecystectomy. METHODS: We conducted a population-based study using the National Health Insurance database. Patients diagnosed with CBD stones and with procedure registry of endoscopic stone removal were included...
November 30, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29192347/pharmacogenetics-of-thiopurines-for-inflammatory-bowel-disease-in-east-asia-prospects-for-clinical-application-of-nudt15-genotyping
#13
REVIEW
Yoichi Kakuta, Yoshitaka Kinouchi, Tooru Shimosegawa
The thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely used to treat inflammatory bowel disease. However, the incidence of adverse reactions is high, particularly in Asia, and the mechanisms of toxicity in Asian populations remain unclear. Thiopurine S-methyltransferase (TPMT) is a well-known enzyme that inactivates AZA or 6-MP through methylation and is one of the few pharmacogenetic predictors used in clinical settings in Western countries. Individuals carrying TPMT-deficient genetic variants require reduced drug doses, but this treatment modification is are not applicable to East Asian populations...
November 30, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29188387/efficacy-and-safety-of-twice-daily-rabeprazole-maintenance-therapy-for-patients-with-reflux-esophagitis-refractory-to-standard-once-daily-proton-pump-inhibitor-the-japan-based-extend-study
#14
Yoshikazu Kinoshita, Mototsugu Kato, Mitsuhiro Fujishiro, Hironori Masuyama, Ryo Nakata, Hisanori Abe, Shinji Kumagai, Yasushi Fukushima, Yoshiumi Okubo, Seiichiro Hojo, Motoyasu Kusano
BACKGROUND: Rabeprazole at 10 or 20 mg twice daily (b.i.d.) has been reported to be highly effective in the treatment of proton pump inhibitor (PPI)-resistant reflux esophagitis (RE) that is refractory to the standard once-daily PPI regimen. We evaluated the efficacy and safety of rabeprazole maintenance therapy at 10 mg once daily (q.d.) or b.i.d. for longer than 8 weeks. METHODS: Patients with RE refractory to standard PPI regimens for at least 8 weeks were enrolled...
November 29, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29177681/clinical-strategy-of-diagnosing-and-following-patients-with-nonalcoholic-fatty-liver-disease-based-on-invasive-and-noninvasive-methods
#15
REVIEW
Masato Yoneda, Kento Imajo, Hirokazu Takahashi, Yuji Ogawa, Yuichiro Eguchi, Yoshio Sumida, Masashi Yoneda, Miwa Kawanaka, Satoru Saito, Katsutoshi Tokushige, Atsushi Nakajima
Nonalcoholic fatty liver disease (NAFLD) is an important cause of chronic liver injury in many countries. The incidence of NAFLD is rising rapidly in both adults and children, because of the currently ongoing epidemics of obesity and type 2 diabetes. Notably, histological liver fibrosis is recognized as the main predictive factor for the overall long-term outcome of NAFLD, including cardiovascular disease and liver-related mortality. Thus, staging of liver fibrosis is essential in determining the prognosis and optimal treatment for patients with NAFLD and in guiding surveillance for the development of hepatocellular carcinoma (HCC)...
November 24, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29143121/telomere-length-of-gallbladder-epithelium-is-shortened-in-patients-with-congenital-biliary-dilatation-measurement-by-quantitative-fluorescence-in-situ-hybridization
#16
Yuto Aoki, Junko Aida, Youichi Kawano, Ken-Ichi Nakamura, Naotaka Izumiyama-Shimomura, Naoshi Ishikawa, Tomio Arai, Yoshiharu Nakamura, Nobuhiko Taniai, Eiji Uchida, Kaiyo Takubo, Toshiyuki Ishiwata
BACKGROUND: Congenital biliary dilatation (CBD) is a congenital malformation involving both dilatation of the extrahepatic bile duct and pancreaticobiliary maljunction. Persistent reflux of pancreatic juice injures the biliary tract mucosa, resulting in chronic inflammation and higher rates of carcinogenesis in the biliary tract, including the gallbladder. Telomeres are repetitive DNA sequences located at the ends of chromosomes. Chromosomal instability due to telomere dysfunction plays an important role in the carcinogenesis of many organs...
November 15, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29138921/world-trends-for-h-pylori-eradication-therapy-and-gastric-cancer-prevention-strategy-by-h-pylori-test-and-treat
#17
REVIEW
Hidekazu Suzuki, Hideki Mori
Helicobacter pylori-associated gastritis leads to the development of gastric cancer. Kyoto global consensus report on H. pylori gastritis recommended H. pylori eradication therapy to prevent gastric cancer. To manage H. pylori infection, it is important to choose the appropriate regimen considering regional differences in resistance to clarithromycin and metronidazole. Quinolones and rifabutin-containing regimens are useful as third- and fourth-line rescue therapies.
November 14, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29134330/is-the-incidence-of-esophageal-adenocarcinoma-increasing-in-japan-trends-from-the-data-of-a-hospital-based-registration-system-in-akita-prefecture-japan
#18
Shigeto Koizumi, Satoru Motoyama, Katsunori Iijima
BACKGROUND: At present, squamous cell carcinoma accounts for most esophageal cancers in Japan; however, there is concern that the incidence of esophageal adenocarcinoma in Japan is increasing in comparison to Western countries. Akita Prefecture, with a population of 1 million, has the highest rate of esophageal cancer-associated mortality in Japan; the vast majority of these cases are squamous cell carcinoma. The aim of the present study was to investigate the latest trends in the incidence of esophageal adenocarcinoma in Akita Prefecture using a registration system...
November 14, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29134329/esophageal-motility-disorders-new-perspectives-from-high-resolution-manometry-and-histopathology
#19
REVIEW
Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Go Hasegawa, Shuji Terai
High-resolution manometry (HRM) and peroral endoscopic myotomy (POEM) have contributed significantly to the field of esophageal motility disorders in recent years. The development of HRM has categorized various esophageal motility disorders with a focus on a diverse range of manometric anomalies. Additionally, the Chicago classification criteria is widely used for manometric diagnosis. Moreover, POEM was introduced as a minimally invasive radical therapy for achalasia and shows promise for other spastic esophageal motility disorders as well...
November 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29134328/correction-to-efficacy-and-safety-of-glecaprevir-pibrentasvir-in-hcv-infected-japanese-patients-with-prior-daa-experience-severe-renal-impairment-or-genotype-3-infection
#20
Hiromitsu Kumada, Tsunamasa Watanabe, Fumitaka Suzuki, Kenji Ikeda, Ken Sato, Hidenori Toyoda, Masanori Atsukawa, Akio Ido, Akinobu Takaki, Nobuyuki Enomoto, Koji Kato, Katia Alves, Margaret Burroughs, Rebecca Redman, David Pugatch, Tami J Pilot-Matias, Preethi Krishnan, Rajneet K Oberoi, Wangang Xie, Kazuaki Chayama
Unfortunately, in the original publication of this article, the copyright line was incorrectly published in PDF as "© The Author(s) 2017" instead of "©The Author(s) 2017 This article is an open access publication" and also the CC-BY description was not included. The description should be as follows.
November 13, 2017: Journal of Gastroenterology
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