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Journal of Gastroenterology

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https://www.readbyqxmd.com/read/30643982/efficacy-and-safety-of-a-crystalline-lactulose-preparation-sk-1202-in-japanese-patients-with-chronic-constipation-a-randomized-double-blind-placebo-controlled-dose-finding-study
#1
Kunio Kasugai, Hisakazu Iwai, Noboru Kuboyama, Aya Yoshikawa, Shin Fukudo
BACKGROUND: Clinical evidence of lactulose for chronic constipation in Japan was lacking. We performed a randomized, double-blind, placebo-controlled, dose-finding study in Japanese patients with chronic constipation to estimate the optimal clinical dose of lactulose. METHODS: Overall, 250 patients were randomized to receive SK-1202 (13, 26, or 39 g/day, as crystalline lactulose dosage) or placebo twice daily (morning and evening) orally for 2 weeks. The primary endpoint was the change from baseline frequency of spontaneous bowel movements (SBMs) at Week 1...
January 14, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30643981/alcoholic-and-non-alcoholic-steatohepatitis-global-perspective-and-emerging-science
#2
REVIEW
Gurmehr Brar, Hidekazu Tsukamoto
Alcohol and high-fat diet are two major risk factors responsible for metabolic diseases, which are manifested as steatohepatitis and liver cancer in the liver, and chronic pancreatitis and pancreatic adenocarcinoma (PDAC) in the pancreas. These metabolic diseases are becoming increasingly prevalent around the globe, and more importantly, their two major etiologies commonly coexist to precipitate the disease processes. To highlight the importance of these metabolic diseases, Japanese Society of Gastroenterology (JSGE) and National Institute on Alcoholism and Alcohol Abuse of National Institute of Health cosponsored the JSGE's 7th International Forum jointly held with the 12th International Symposium on ALPD and Cirrhosis...
January 14, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30612205/ns5a-p32-deletion-as-a-factor-involved-in-virologic-failure-in-patients-receiving-glecaprevir-and-pibrentasvir
#3
Hayato Uemura, Yoshihito Uchida, Jun-Ichi Kouyama, Kayoko Naiki, Shohei Tsuji, Kayoko Sugawara, Masamitsu Nakao, Daisuke Motoya, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya, Satoshi Mochida
BACKGROUND: This study sought to clarify the factors involved in virologic failure in patients with HCV receiving retreatment with glecaprevir/pibrentasvir (GLE/PIB) in real-world practice. METHODS: Forty-two patients who had previously received direct-acting antivirals (DAAs) therapies consisting of 35, 3, 3, and 1 patient(s) with genotype (GT)-1b, GT-2a, GT-2b, and GT-3b HCV, respectively, received GLE/PIB for 12 weeks. Resistance-associated substitutions (RASs) at baseline were evaluated, and the dynamics of NS5A-RASs were assessed by deep sequencing in patients showing virologic failure...
January 5, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30607612/epidemiological-analysis-of-achalasia-in-japan-using-a-large-scale-claims-database
#4
Hiroki Sato, Hiroshi Yokomichi, Kazuya Takahashi, Kentaro Tominaga, Takeshi Mizusawa, Naruhiro Kimura, Yuzo Kawata, Shuji Terai
BACKGROUND: Achalasia is a well-known esophageal motility disorder, but epidemiological studies in Japan are lacking. We investigated the incidence and period prevalence of achalasia in Japan, including the rate of coexistence of esophageal carcinoma, and evaluated treatment trends. METHODS: To estimate the nationwide number of patients with achalasia, a large-scale insurance claims database from 2005 to 2017 were used for our analyses. Patients with achalasia and coexistence of esophageal carcinoma were identified based on the diagnosis code registered...
January 3, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30603885/feasibility-of-a-simplified-narrow-band-imaging-classification-system-for-barrett-s-esophagus-for-novice-endoscopists
#5
Hiroto Furuhashi, Kenichi Goda, Yuichi Shimizu, Masayuki Kato, Masakazu Takahashi, Akira Dobashi, Koji Hirata, Ayane Oba, Taku Shigesawa, Masaki Inoue, Hiroaki Matsui, Chika Kinoshita, Yoshitaka Ando, Masahiro Ikegami, Tadakazu Shimoda, Mototsugu Kato
BACKGROUND: Narrow-band imaging (NBI) classifications for Barrett's esophagus have been proposed for the detection of early esophageal adenocarcinoma. We developed a simplified classification system with demonstrated high diagnostic accuracy and reproducibility among experienced endoscopists, but the feasibility of this system among novice endoscopists was unclear. METHODS: In the present study, eight novice endoscopists with no experience of magnification endoscopy were asked to review 248 images of Barrett's esophagus (72 dysplastic, 176 non-dysplastic) obtained using high-definition magnification endoscopy with NBI 6 weeks before (1st test), immediately after (2nd test), and 6 weeks after (3rd test) being taught the simplified classification system...
January 2, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30607613/marked-impact-of-tumor-location-on-the-appropriate-cutoff-values-and-the-prognostic-significance-of-the-lymph-node-ratio-in-stage-iii-colon-cancer-a-multi-institutional-retrospective-analysis
#6
Eiji Shinto, Hideyuki Ike, Jin-Ichi Hida, Hirotoshi Kobayashi, Yojiro Hashiguchi, Yoshiki Kajiwara, Kazuo Hase, Hideki Ueno, Kenichi Sugihara
BACKGROUND: The prognostic significance of lymph node ratio (LNR) is not constant among studies. Exploration of appropriate location-specific cutoffs might be necessary because the number of lymph nodes harvested is generally higher in right than in left colon cancer. We aimed to determine appropriate cutoff values of LNR in right and left colon cancer and to clarify its clinical significance. METHODS: The clinicopathologic data of 5463 patients with stage III colon cancer were collected...
January 1, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30599053/establishment-of-a-system-to-evaluate-the-therapeutic-effect-and-the-dynamics-of-an-investigational-drug-on-ulcerative-colitis-using-human-colonic-organoids
#7
Ryu Nishimura, Tomoaki Shirasaki, Kiichiro Tsuchiya, Yoshihide Miyake, Yusuke Watanabe, Shuji Hibiya, Sho Watanabe, Tetsuya Nakamura, Mamoru Watanabe
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with an intractable, recurrent course. The goal of UC therapy is to target mucosal healing because immune-suppressive therapy for UC frequently results in relapse. However, few drugs directly target mucosal healing. We, therefore, aim to evaluate the therapeutic effect of an investigational drug on intestinal epithelial cells in an in vitro UC model using human colonic organoids. METHODS: Colonic organoids were isolated from human colon and cultured...
January 1, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30599052/long-awaited-treatment-for-hepatitis-c-virus-decompensated-cirrhosis
#8
EDITORIAL
Kiminori Kimura
No abstract text is available yet for this article.
January 1, 2019: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30519748/gut-microbiota-dysbiosis-worsens-the-severity-of-acute-pancreatitis-in-patients-and-mice
#9
Yin Zhu, Cong He, Xueyang Li, Yan Cai, Jinxiang Hu, Yuanhang Liao, Jianhua Zhao, Liang Xia, Wenhua He, Linmeng Liu, Chun Luo, Xu Shu, Qiang Cai, Youxiang Chen, Nonghua Lu
BACKGROUND: The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the infectious complications of AP are commonly associated with enteric bacteria, yet whether gut microbiota dysbiosis participants in AP severity remains largely unknown. METHODS: We collected clinical information and fecal samples from 165 adult participants, including 41 with mild AP (MAP), 59 with moderately severe AP (MSAP), 30 with severe AP (SAP) and 35 healthy controls (HC)...
December 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30519747/usefulness-of-transabdominal-ultrasonography-for-assessing-ulcerative-colitis-a-prospective-multicenter-study
#10
Kenji Kinoshita, Takehiko Katsurada, Mutsumi Nishida, Satomi Omotehara, Reizo Onishi, Katsuhiro Mabe, Aki Onodera, Mami Sato, Kazunori Eto, Mitsutoshi Suya, Atsuo Maemoto, Toru Hasegawa, Junji Yamamoto, Daiki Mitsumori, Shinji Yoshii, Kota Ono, Naoya Sakamoto
BACKGROUND: Transabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn's disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC. METHODS: Altogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. All patients underwent US and CS within 2 days at five facilities...
December 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30515563/pancreatic-cancer-arising-from-the-remnant-pancreas-after-pancreatectomy-a-multicenter-retrospective-study-by-the-kyushu-study-group-of-clinical-cancer
#11
Daisuke Hashimoto, Kota Arima, Shigeki Nakagawa, Yuji Negoro, Toshihiko Hirata, Masahiko Hirota, Masafumi Inomata, Kengo Fukuzawa, Takefumi Ohga, Hiroshi Saeki, Eiji Oki, Yo-Ichi Yamashita, Akira Chikamoto, Hideo Baba, Yoshihiko Maehara
BACKGROUND: After initial pancreatic resection, local recurrence of pancreatic cancer (PC) or new primary PC can develop in the remnant. There are limited data available regarding this so-called remnant PC. The aim of this retrospective study was to clarify the clinical features and establish a treatment strategy for remnant PC. METHODS: A multicenter retrospective study with the Kyushu Study Group of Clinical Cancer was carried out. Clinical data from 50 patients who developed remnant PC were analyzed...
December 4, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30506232/independent-and-additive-effects-of-pnpla3-and-tm6sf2-polymorphisms-on-the-development-of-non-b-non-c-hepatocellular-carcinoma
#12
Maneerat Raksayot, Natthaya Chuaypen, Apichaya Khlaiphuengsin, Nutcha Pinjaroen, Sombat Treeprasertsuk, Yong Poovorawan, Yasuhito Tanaka, Pisit Tangkijvanich
BACKGROUND: This study was aimed at evaluating the association between single nucleotide polymorphisms (SNPs) in the PNPLA3, NCAN, TM6SF2 and MBOAT7 and hepatocellular carcinoma (HCC) development in Thai patients according to underlying etiologies of liver disease. METHODS: These SNPs were determined by allelic discrimination in blood samples of 105 healthy controls and 530 patients with HCC [270 with hepatitis B virus (HBV-HCC), 131 with hepatitis C virus (HCV-HCC), and 129 with non-B, non-C HCC (NBNC-HCC) matched for age and gender]...
November 30, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30498904/a-nationwide-survey-on-non-b-non-c-hepatocellular-carcinoma-in-japan-2011-2015-update
#13
Ryosuke Tateishi, Koji Uchino, Naoto Fujiwara, Tetsuo Takehara, Takeshi Okanoue, Masataka Seike, Hitoshi Yoshiji, Hiroshi Yatsuhashi, Masahito Shimizu, Takuji Torimura, Mitsuhiko Moriyama, Isao Sakaida, Hiroyuki Okada, Tetsuhiro Chiba, Makoto Chuma, Kazuhiko Nakao, Hajime Isomoto, Yutaka Sasaki, Shuichi Kaneko, Tsutomu Masaki, Kazuaki Chayama, Kazuhiko Koike
BACKGROUND: We previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan. METHODS: To update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption...
November 29, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30478724/characterization-of-fungal-dysbiosis-in-japanese-patients-with-inflammatory-bowel-disease
#14
Takayuki Imai, Ryo Inoue, Yuki Kawada, Yasuhiro Morita, Osamu Inatomi, Atsushi Nishida, Shigeki Bamba, Masahiro Kawahara, Akira Andoh
BACKGROUND AND AIMS: There are no previous reports describing the fecal fungal microbiome of a Japanese population using advanced molecular techniques. In this study, we performed a molecular analysis on the fungal microbial community of a healthy Japanese population and patients with inflammatory bowel diseases (IBDs). PATIENTS AND METHODS: Fecal samples were obtained from 18 patients with inactive ulcerative colitis (UC, n = 18), Crohn's disease (CD, n = 20) and healthy volunteers (n = 20)...
November 26, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30478723/fluid-sequestration-is-a-useful-parameter-in-the-early-identification-of-severe-disease-of-acute-pancreatitis
#15
Tsuyoshi Takeda, Yousuke Nakai, Suguru Mizuno, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Takeo Watanabe, Naminatsu Takahara, Dai Mouri, Hirofumi Kogure, Yukiko Ito, Kenji Hirano, Minoru Tada, Hiroyuki Isayama, Kazuhiko Koike
BACKGROUND: Early identification of severe disease of acute pancreatitis (AP) is of critical importance to improve the prognosis. Fluid sequestration (FS), calculated from administrated fluid and fluid output, is a simple prognostic parameter. We examined its utility in the early phase of AP. METHODS: We retrospectively investigated AP patients between January 2009 and April 2017. We compared FS in the first 24 h (FS24) with FS in the first 48 h (FS48) and administrated fluid volume within the first 24 h (FV24)...
November 26, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30413874/response-to-the-letter-by-dr-naoya-yamada-and-dr-koichi-mizuta-regarding-our-manuscript-mac-2-binding-protein-glycan-isomer-m2bpgi-is-a-new-serum-biomarker-for-assessing-liver-fibrosis-more-than-a-biomarker-of-liver-fibrosis
#16
LETTER
Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, Kenichiro Araki, Norihiro Ishii, Atsushi Kuno, Hisashi Narimatsu, Masashi Mizokami
No abstract text is available yet for this article.
November 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30413873/advanced-assessment-of-serum-mac-2-binding-protein-glycosylation-isomer-in-patients-with-biliary-atresia
#17
LETTER
Naoya Yamada, Koichi Mizuta
No abstract text is available yet for this article.
November 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30413872/short-and-long-term-outcomes-of-endoscopic-submucosal-dissection-for-early-gastric-cancer-in-the-remnant-stomach-after-gastrectomy
#18
Yohei Yabuuchi, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka, Noboru Kawata, Masao Yoshida, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Hirotoshi Ishiwatari, Kinichi Hotta, Hiroyuki Matsubayashi, Hiroyuki Ono
BACKGROUND: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in the remnant stomach is a minimally invasive treatment. Few studies compared the technical difficulty of ESD involving the suture line and anastomosis, and information on long-term outcomes is insufficient. This study aimed to elucidate the short- and long-term outcomes of ESD for EGC in the remnant stomach. METHODS: We investigated patients who underwent ESD for EGC in the remnant stomach between September 2002 and March 2016...
November 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30406847/diagnostic-efficacy-of-dual-focus-endoscopy-with-narrow-band-imaging-using-simplified-dyad-criteria-for-superficial-esophageal-squamous-cell-carcinoma
#19
Akira Dobashi, Kenichi Goda, Hiroto Furuhashi, Hiroaki Matsui, Yuko Hara, Shunsuke Kamba, Masakuni Kobayashi, Kazuki Sumiyama, Shinichi Hirooka, Shigeharu Hamatani, Elizabeth Rajan, Masahiro Ikegami, Hisao Tajiri
BACKGROUND: Our previous studies have shown the diagnostic utility of a newly developed dual-focus endoscope with narrow-band imaging (DF-NBI) and simplified dyad criteria for detection of superficial esophageal squamous cell carcinoma (SESCC). This clinical trial aimed to study the diagnostic efficacy of DF-NBI with dyad criteria for detecting SESCC compared to white light imaging (WLI). METHODS: This was a single-arm prospective comparative trial. We enrolled 170 consecutive high-risk patients for esophageal squamous cell carcinoma...
November 8, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30406288/impact-of-endoscopic-ultrasonography-on-diagnosis-of-pancreatic-cancer
#20
REVIEW
Masayuki Kitano, Takeichi Yoshida, Masahiro Itonaga, Takashi Tamura, Keiichi Hatamaru, Yasunobu Yamashita
Accumulated evidence has revealed that endoscopic ultrasonography (EUS) has had a great impact on the clinical evaluation of pancreatic cancers. EUS can provide high-resolution images of the pancreas with a quality regarded as far surpassing that achieved on transabdominal ultrasound (US), computed tomography (CT), or magnetic resonance imaging (MRI). EUS is particularly useful for the detection of small pancreatic lesions, while EUS and its related techniques such as contrast-enhanced EUS (CE-EUS), EUS elastography, and EUS-guided fine needle aspiration (EUS-FNA) are also useful in the differential diagnosis of solid or cystic pancreatic lesions and the staging (T-staging, N-staging, and M-staging) of pancreatic cancers...
November 7, 2018: Journal of Gastroenterology
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