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Pakistan Journal of Pharmaceutical Sciences

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https://www.readbyqxmd.com/read/27731836/review-glycyrrhiza-glabra-l-liquorice
#1
Ghulam Dastagir, Muhammad Afzal Rizvi
Medicinal plants are being used for treating various diseases. According to World Health Organization 80% of the world population depends on indigenous medicinal plant remedies. Herbal medicine employs fruits, vegetables, as dry materials or their extracts for the treatment of different diseases and health maintenance. Glycyrrhiza glabra (Liquorice) has been used in Europe since prehistoric times. It is well documented in written form starting with the ancient Greeks. Glycyrrhizin is the major active constituent obtained from liquorice roots, one of the most widely used in herbal preparations for the treatment of liver complaints...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731835/review-selenium-its-metabolism-and-relation-to-exercise
#2
Abdulkerim Kasim Baltaci, Rasim Mogulkoc, Mustafa Akil, Mursel Bicer
Selenium (Se), which is commonly found in nature, is one of the essential trace elements necessary for the normal development of human and animal organisms. Selenium was first defined in 1818 by the Swedish chemist Berzelius in sulfuric acid residues. At the end of 1960s, the role of selenium in human health began to attract attention and human diseases that resembled animal diseases responding to selenium was started to be investigated. Selenium, which is highly important for human health, is necessary for a variety of metabolic processes, including thyroid hormone metabolism, protection against oxidative stress and immunity functions...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731834/report-most-common-body-parts-infected-with-scabies-in-children-and-its-control
#3
Nasira Khatoon, Aly Khan, M Arshad Azmi, Adnan Khan, S Shahid Shaukat
Scabies a skin disease caused by mite Sarcoptes scabiei is common in Pakistan and spreads mostly where there is frequent skin to skin contact. In the present study children belonging to four age groups 0-3 years, 4-6 years, 7-9 years and 10-12 years attending Baqai Institute and Hospital Gadap from June-September 2013 were examined. The association between scabies of different human parts and age for boys was significant (p<0.01), while for girls it was highly significant (p<0.001). The most frequent body parts infected with scabies lesions were hands, head and feet...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731833/report-antibacterial-activity-of-sea-buckthorn-hippophae-rhamnoides-l-against-methicillin-resistant-staphylococcus-aureus-mrsa
#4
Muhammad Imran Qadir, Khizar Abbas, Adnan Younus, Rehan Sadiq Shaikh
Objective of the present study was to investigate the antibacterial activity of Sea buckthorn (Hippophae rhamnoides L.) berries and leaves against methicillin resistant Staphylococcus aureus (MRSA) by using the standard disc diffusion method. Chloroform, n-hexane and aqueous extract of the plant parts were used. Doses of 2mg/ml, 4 mg/ml and 6mg/ml were tested against the microorganism, and the zone of inhibition was compared against the standard drug vancomycin. Results indicated that n-hexane and chloroform extracts of berries and n-hexane extract leaves showed significant (p<0...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731832/report-renovation-of-a-traditional-ergh-al-nassa-pill-hab-to-a-standard-pharmaceutical-molded-tablet
#5
Arman Zargaran, Saeid Daneshamouz, Gholamreza Kordafshari, Abdolali Mohagheghzadeh
The Ergh-al-Nassa pill (Hab) is a traditional combination suggested as one of the most effective preparations useful for treatment of sciatica. Although traditional preparations can be applied as new therapeutic drugs for investigations and clinical trials, they need to be reformulated to achieve pharmacopoeial standards for modern medicine. In this research, based on seven traditional Persian pharmacopeias for Ergh-al-NassaHab, nine different molded tablets were reformulated. Each formulation comprised the same amount of colchicum, ginger, aloe and yellow myrobalan fruit...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731831/evaluation-of-aucklandia-lappa-decne-extracts-as-antiulcer-activity-in-animals
#6
Xian Yang, Xue Zhang, Shui-Ping Yang, Tao Le, Bin Chen
Aucklandialappa Decne (ALD) is one of the traditional herbs to treat various kinds of disorders including asthma, cough, vomit, diarrhea, hepatitis and cholecystitis. However, its effects on indigestion and particularly antiulcer activity of ethanol extract have not been studied. In the study, the Aucklandia lappa Decne extract (ALDE) was investigated to see if it againstgastric injury effects through traditional pathways. Ethyl alcohol and epinephrine hydrochloride were used to induce acute gastric mucous membrane damage in adult SD rats and Kunming mice, respectively...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731830/detection-of-antibiotic-residues-in-poultry-meat
#7
Abdul Sajid, Natasha Kashif, Nasira Kifayat, Shabeer Ahmad
The antibiotic residues in poultry meat can pose certain hazards to human health among them are sensitivity to antibiotics, allergic reactions, mutation in cells, imbalance of intestinal micro biota and bacterial resistance to antibiotics. The purpose of the present paper was to detect antibiotic residue in poultry meat. During the present study a total of 80 poultry kidney and liver samples were collected and tested for detection of different antibiotic residues at different pH levels Eschericha coli at pH 6, 7 and Staphyloccocus aureus at pH 8 & 9...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731829/quantitative-structure-activity-relationship-qsar-studies-on-nitazoxanide-based-analogues-against-clostridium-difficile-in-vitro
#8
Han Zhang, Xiwang Liu, Yajun Yang, Jianyong Li
Quantitative structure activity relationship (QSAR) has been established between the various physiochemical parameters of a series of nitazoxanide-based analogues and its antibacterial activity against Clostridium difficile. Genetic function approximation (GFA) and comparative molecular field analysis (CoMFA) techniques were used to identify the descriptors that have influence on biological activity. The most influencing molecular descriptors identified in 2D-QSAR include spatial, topological, and electronic descriptors, while electrostatic and stereoscopic fields were the most influencing molecular descriptors identified in 3D-QSAR...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731828/pharmacokinetic-and-bioequivalence-studies-of-immediate-release-diclofenac-potassium-tablets-50mg-in-healthy-volunteers
#9
Huma Ali, Muhammad Harris Shoaib, Farya Zafar, Muhammad Hanif, Rabia Bushra, Asia Naz, Raheela Khursheed
This study was conducted with the aim to determine the pharmacokinetic and bioequivalence of diclofenac potassium 50 mg test (F4) tablet formulation with reference product (Caflam). Present study was single dose, randomized, two phase cross over design, conducted in 12 healthy Pakistani volunteers and planned in accordance with FDA guidelines. In this study a simple, selective, sensitive and reproducible HPLC procedure was developed and validated for the estimation of diclofenac potassium in plasma. The process was validated in the range of 50 - 0...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731827/preparation-and-in-vitro-characterization-of-solid-dispersion-floating-tablet-by-effervescent-control-release-technique-with-improved-floating-capabilities
#10
Peeush Singhal, Rajneesh Dutt Kaushik, Vijay Jyoti Kumar, Anurag Verma, Pranav Gupta
In this Research, an effort has been done for the development of effervescent controlled release floating tablet (ECRFT) from solid dispersions (SDs) of diclofenac sodium (DS) for upsurge the solubility and dissolution rate. ECRFT of DS was prepared by using SDs of DS and its SDs prepared with PEG as carrier using thermal method (Simple fusion). SDs of DS were formulated in many ratio (1:1, 1:2, 1:3 and 1:4). Prepared SDs was optimized for its solubility, % drug content and % dissolution studies. Tablets were formulated by using optimized SDs products and all formulation was evaluated for various parameters...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731826/calculating-osmotic-pressure-of-glucose-solutions-according-to-asog-model-and-measuring-it-with-air-humidity-osmometry
#11
Guocui Wei, Tingting Zhan, Xiancheng Zhan, Lan Yu, Xiaolan Wang, Xiaoying Tan, Chengrong Li
The osmotic pressure of glucose solution at a wide concentration range was calculated using ASOG model and experimentally determined by our newly reported air humidity osmometry. The measurements from air humidity osmometry were compared with the well-established freezing point osmometry and ASOG model calculations at low concentrations and with only ASOG model calculations at high concentrations where no standard experimental method could serve as a reference for comparison. Results indicate that air humidity osmometry measurements are comparable to ASOG model calculations at a wide concentration range, while at low concentrations freezing point osmometry measurements provide better comparability with ASOG model calculations...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731825/anxiolytic-and-antidepressant-activity-of-different-methanolic-extracts-of-melia-azedarach-linn
#12
Humera Ishaq
Present study was planned to search for neuropharmacological properties of methanolic extracts of different parts of Melia azedarach Linn. because conventional medicine shows adverse effects. Recently natural products are studied worldwide, as safer alternatives, which are not duly supported with scientifically proved data. Melia azedarach (Bakayan, China berry tree) is medium sized tree belonging to family Meliaceae. Traditional use of plant is as anthelmintic, antilithic and diuretic. Topical application of oil for cramps and rheumatism is beneficial...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731824/microbial-and-chemical-analysis-of-illicit-drugs-samples-confiscated-from-different-areas-of-pakistanmicrobial-and-chemical-analysis-of-illicit-drugs-samples-confiscated-from-different-areas-of-pakistan
#13
Shahzad Hussain, Zainab Khattak, Sidra Mahmood, Farnaz Malik, Humayun Riaz, Syed Atif Raza, Samiullah Khan
The microbial and chemical analysis of illicit drug samples from different areas of Pakistan i.e. Quetta, Karachi, Lahore and Islamabad was conducted in a cross-sectional study at National Institute of Health, Islamabad. The drug samples were confiscated by Anti Narcotics Force (ANF), Pakistan. Microbial analysis was done by estimating bioburden which revealed the presence of gram negative and positive bacteria's, fungus, Streptococcus, Staphylococcus species. Trypton soya agar was used for total aerobic count, MacConkey agar for gram-negative bacteria, Sabouraud dextrose agar for fungus and Vogel-Johnson agar for Streptococcus and Staphylococcus species...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731823/does-porphyrin-suppres-the-apoptotic-and-necrotic-effects-of-bovine-herpes-virus-type-1-bohv-1-and-herpes-simplex-virus-type-1-hsv-1
#14
Beyza Yavuz, Zafer Yazici
In this study, antiviral effect of porphyrin was investigated. Cooper strain of Bovine Herpes Virus type 1(BoHV-1) and Kos strain of Herpes Simplex Virus type-1 (HSV-1) were used to determine the potential of porphyrins to inhibit infection in vitro (with morphological and cytopathological criteria). Apoptotic and necrotic changes were determined by using DAPI and propidium staining. The non-cytotoxic dose of porphyrin (NCD-p) was initially calculated as 312.50µg/mL on MDBK and Vero cells. The apoptotic cell (APC) count was found 10% with BoHV-1 while it was 5...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731822/effect-of-calcium-hypochlorite-and-chloramine-on-blood-biochemistry-and-sodium-pentobarbital-induced-sleeping-time-in-mice
#15
Sidra Ishaq, Muhammad Adil Rasheed, Muhammad Ashraf, Imran Altaf, Saima Rehmat, Ghulam Fatima
Disinfectants are chemical agents used to eradicate, deactivate or kill microorganisms. Chemical disinfectants especially chlorine compound are extensively used for water sanitization. Among these calcium hypochlorite and chloramines are commonly used now a day. Large number of chemical compounds, drugs and endogenous substances are metabolized by hepatic enzymes known as cytochrome P450 enzyme system. Many chemicals are capable of enzyme induction. Enzyme induction may change the metabolism of other drugs and endogenous substances which may alter the plasma concentration of these chemicals...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731821/rauwolfia-serpentina-improves-altered-glucose-and-lipid-homeostasis-in-fructose-induced-type-2-diabetic-mice
#16
Muhammad Bilal Azmi, Shamim A Qureshi
Rauwolfia serpentina is well-reported in traditional medicines for the treatment of hypertensive and neurological disorders. However, its antidiabetic potential has been currently described in both alloxan-treated and normoglycemic mice. Present effort was carried out to investigate the effect of methanol root extract (MREt) of R.serpentina in fructose-induced type 2 diabetic mice. Experimental mice were grouped into normal control (distilled water 1ml/kg) and fructose-induced type 2 diabetic groups (10% fructose 1 ml/kg)...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731820/effects-of-dexmedetomidine-on-the-deformability-of-erythrocyte-in-patients-with-laparoscopic-cholecystectomy
#17
Xming Yang, Jie Xie, Jun Liu, Tao Wang
This study aims to study the impact of dexmedetomidine on the deformability of erythrocyte in patients with laparoscopic cholecystectomy. 40 patients scheduled for laparoscopic cholecystectomy were randomly divided into 2 groups: Dexmedetomidine group (0.5µg/kg loading within 10 min and 0.5μg•kg-1•h-1maintenance to the end of pneumoperitoneum, n=20, Group A) and control group (normal saline at the identical, n=20, Group B). The induction and maintenance of anesthesia of two groups were identical. Erythrocyte deformability index (EI) and haematocrit (Hct) were assayed before anesthesia and after the operation...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731819/synthesis-antibacterial-and-antifungal-possession-of-amino-acids-containing-sulfonamide-moieties
#18
Muhammad Abdul Qadir, Mahmood Ahmed, Anum Khaleeq
Sulfonamides were developed by the simple reaction of amino acid with p-toluenesulfonyl chloride and structures of the new products (2a, 2b and 2c) were confirmed by elemental and spectral analysis (FT-IR, 1HNMR and13CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against two sensitive bacteria belonging to both gram positive and gram-negative types and two fungi. The synthesized sulfonamides (2a, 2b, 2c) exhibited excellent antifungal activities against the tested fungi...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731818/metal-ii-complexes-of-ethambutol-as-good-enzyme-inhibitor-and-promising-antioxidant
#19
Muhammad Jahangir, Ume Farwa, Farhana Mazhar, Afza Malik, Ejaz Ahmad
Ethambutoldihydrogenchloride (EMB) with chemical formula C10H24N2O2.2HCl is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogen is substituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is an FDA approved drug and has been used for treatment of tuberculosis since 1960's. Prolong use of EMB has a side effect of visual impairment and in literature it is related with the depletion of Zn metal from the body. As it is a good chelating agent, many metal II complexes have been synthesized with anti-tubercular activity...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27731817/gc-ms-analyses-of-the-volatiles-of-houttuynia-cordata-thunb
#20
Zhan-Nan Yang, Shi-Qiong Luo, Jing Ma, Dan Wu, Liang Hong, Zheng-Wen Yu
GC-MS is the basis of analysis of plant volatiles. Several protocols employed for the assay have resulted in inconsistent results in the literature. We developed a GC-MS method, which were applied to analyze 25 volatiles (α-pinene, camphene, β-pinene, 2-methyl-2-pentenal, myrcene, (+)-limonene, eucalyptol, trans-2-hexenal, γ-terpinene, cis-3-hexeneyl-acetate, 1-hexanol, α-pinene oxide, cis-3-hexen-1-ol, trans-2-hexen-1-ol, decanal, linalool, acetyl-borneol, β-caryophyllene, 2-undecanone, 4-terpineol, borneol, decanol, eugenol, isophytol and phytol) of Houttuynia cordata Thunb...
September 2016: Pakistan Journal of Pharmaceutical Sciences
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