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Pakistan Journal of Pharmaceutical Sciences

Muhammad Mukhtiar, Syed Umer Jan, - IhsanUllah, Rahman Gul, Abid Hussain, Essa Ali, - IzharUllah, Abdul Jabbar, Muhammad Akram, Sibghat Mansoor, Muhammad Farid Khan
Glutathione is an essential antioxidant of living organism that provides a primary protection against metals toxicity. A significant amount of glutathione is present in blood erythrocytes, plasma and liver hepatocytes to protect them from oxidative damage from both external and internal oxidants. Metalo-element palladium has numerous pharmacological, clinical and toxicological compensations, like palladium is used as anti-viral, anti-bacterial, neuro-protective and anti-tumor agent. However studies have also indicated some mild to serious toxic effects of palladium metallo-elements...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Muhammad Ahsan, Muhammad Bilal Azmi, Syed Danish Haseen Ahmed, Sadia Ikhlaque Sheikh, Hina Akram Mudassir, Tehseen Iqbal, Fauzia Imtiaz
eart failure is a progressive, chronic disorder. Insulin resistance (IR) has been more and more involved as a preliminary metabolic perturbance predisposing to hyperglycemia, hyperlipidemia and atherosclerosis with others heart diseases. To investigate the relation of insulin resistance (IR) in non-diabetic heart failure patients this case-control study was carried out to ascertain the presence of IR with the aid of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in non-diabetic heart failure patients (NDHF patients) compared with healthy controls...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Ghulam Mustafa, Rawaba Arif, Shazia Anwer Bukhari, Muhammad Ali, Sumaira Sharif, Asia Atta
Citrate synthase (CS) is involved in citric acid biosynthesis which is a well-established metabolic pathway. The condensation of acetyl-CoA with oxaloacetate is catalyzed by CS. Citric acid (CA) has a number of applications in pharmaceutical industry. CA in combination with bicarbonates is used as an effervescent in the preparations of tablets and powders. It has also been used as an anticoagulant and acidulant to form mild astringent. In current study, detailed structural and functional analyses of CS protein were carried out using various bioinformatics tools...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Amna Ali Saddi, Azza Mostafa Mohamed, Abdulkader Mohamed Shaikh
The aim of this investigation was to study the antidiabetic impact of Cucumis melo var. flexuosus and/or Phoenix dactylifera fruit aqueous extracts and their mechanisms in repressing diabetes induced cardio-myopathy in diabetic rats. Type 2 diabetes was promoted in rats by a single intraperitoneal injection of streptozotocin (30mg/kg body wight). C. flexuosus and P. dactylifera extracts (200mg/kg body weight, each) were ingested to diabetic rats daily for a month. The results showed that ingestion of either plant extract or their combination to diabetic rats significantly diminished the glucose level and boosted the insulin concentration in the blood...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Huma Ali, Farya Zafar, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Ammara Manzoor, Ghazala R Naqvi, Riffat Yasmeen, Yousra Shafiq, Anum Tariq, Saba Zubair, Saima Saleem
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Muhammad Hassham Bin Asad, Arooj Fatima Asad, Sumbal Bibi, Kaleem Ullah, Tariq Javed, Majeed Ullah, Atif Ali, Ziaur Rahman Qureshi, Muhammad Imran Amirzada, Yasser Msa Al-Kahraman, Syed Muhammad Farid Hasan, Jean-Marc Sabatier, Albert Rizvanov
Recent recognition about snake bite envenomation on June, 2017 as neglected tropical disease under category-A by World Health Organization advocated again its undeniable importance. Present circumstances reasoned to work on a neglected subspecies of Naja naja, i.e., Naja naja karachiensis (N. n. karachensis) has been documented for frequent deaths in Pakistan. In this study median lethal toxic dose (LD50 ) was determined intraperitoneally in Swiss albino mice and was found to be 2.0µg/g (2.0mg/kg) equal in potency to Naja pallida (red spitting African cobra)...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Irina Ielciu, Daniela Hanganu, Ramona Păltinean, Laurian Vlase, Michel Frédérich, Ana-Maria Gheldiu, Daniela Benedec, Gianina Crişan
Echinocystis lobata (Michx.) Torr. et A.Gray is a spontaneous species in the Romanian flora, lesser studied by scientific literature, but which has proved significant activities in traditional medicine. The present study is aimed to provide data on the polyphenolic compounds in the composition of the flowers of this species and to test their biological potential. Polyphenols were identified and quantified using an HPLC-MS method. Tested biological activities were the cytotoxic, anti-plasmodial and antioxidant ones...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Hina Hasnain, Huma Ali, Farya Zafar, Ali Akbar Sial, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Mehwish Rizvi, Maqsood Ahmed Khan, Huma Shareef, Ghazala R Naqvi, Anum Tariq
Drug-drug interactions (DDIs) are extremely significant concern, particularly in sensitive population including pediatric and geriatric. Propensity for the development of DDIs is high in patients admitted at intensive care units (ICU). This study was conducted to evaluate the DDIs incidence, facts and measures in ICU. From a total of 150 cases studied for ICU patients, with the mean age of 56.37±12.45 years, 55.33% were male and the rest were female 44.66%. The demographic information like age, gender and main diagnosis details of study participants that were extracted from the patients' clinical record...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Muhammad Bilal Azmi, Shamim A Qureshi, Syed Danish Haseen Ahmed, Hina Akram Mudassir, Fauzia Imtiaz, Sumera Rais, Auwais Ahmed Khan, Muhammad Ahsan
Present work seeks to investigate the biochemical parameters in terms of hypoglycemic and hypolipidemic effects of hydro-methanolic roots extract (HyMREt) of Rauwolfia serpentina in type 1 (alloxan induced) diabetic mice. Animals were divided into seven groups, four control groups, and three were test groups (HyMREt at 50, 100, & 150mg/kg). Each treatment was repeated for 14 days regularly in all seven respective groups and afterwards the body weights, fasting blood glucose (FBG), insulin, and serum lipid levels were determined...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Mehboob Alam, Naqab Khan, Khurram Rehman, Samiullah Khan, Zahid Rasul Niazi, Kifayatullah Shah, Natasha Baloch, Barkat Ali Khan
The untreated surface water for drinking and domestic use is an alarming situation to public health especially in prevalence of antibiotics resistant bacteria. This investigation aimed to isolate and identify the antibiotic resistance bacteria in underground water samples in district Dera Ismail Khan, Pakistan. The underground water samples were collected from four different places using hand pumps (Khyber town, riverside, Gomal University and united town). Cultured on nutrient agar media, identified by Gam staining and biochemical tests...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Wei Zhang, Lili Zheng
Through castrated rats osteoporosis models, this study aims to explore whether the intraperitoneal injection of Scutellaria baicalensis extract could prevent the occurrence of osteoporosis and slow down/reverse osteoporosis or not, and further explore the influence on BMMSCs extracted by Scutellaria baicalensis extract. Scutellaria baicalensis extracts on the prevention and treatment of oestrogen shortage and osteoporosis. After the screening of appropriate concentration, in the model of castrated female rats with osteoporosis, rats in prevent group were given intraperitoneal injection of Scutellaria baicalensis extract within 1 week after the castration, and the rats in treatment group were injected Scutellaria baicalensis extract at the abdominal cavity in two months of castration...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Attaur Rehman, Rabia Bushra, Anwar Ejaz Beg, Huma Ali, Farya Zafar, Maria Ashfaq, Shazia Alam, Omer Mustapha, Shumaila Shafique
The initiation of newer techniques and development of mouth dissolving (MD) products has created new avenues of higher patients' compliance. MD formulations are actually lessen the difficulties associated with solid swallowing with better bioavailability of especially poorly soluble drugs. In the current study mouth dissolving tablet (MDT) formulations of cinitapride (1 mg) were prepared by direct compression method using various proportion and combination of superdisintegrants. Nine formulations in three batches were compressed by incorporating low (2%), intermediate (6%) and higher (10%) levels of crospovidone, croscarmellose sodium, sodium starch glycolate...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Syed Ali Raza, Ayoub Rashid Chaudhary, Muhammad Waseem Mumtaz, Abdul Ghaffar, Ahmad Adnan, Abdul Waheed
Synthetic drugs have widely been helpful in management of diabetes mellitus type 2. However, side effects associated with synthetic drugs serve as an impetus to explore plants as alternate mode of treatment. The hydroethanolic leaf extracts of Conocarpus erectus were evaluated for phenolic contents, flavonoid distribution, antioxidant activity and antidiabetic potential. The maximum extract yield, total phenolic and flavonoid contents were exposed by 60% ethanolic extract. The Antioxidant and anti α-glucosidase tendency of 60% ethanolic extract was the most promising and complemented by in-vivo antihyperglycemic impact on mice...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Muhammad Jihad Sandikapura, Shaik Nyamathulla, Mohamed Ibrahim Noordin
The study was aimed to perform aqueous extraction of two plants using different extraction methods, and evaluate their antioxidant and antidiabetic potential. Plant materials were extracted by maceration, soxhlet, sonication and fresh juice methods to produce aqueous extracts. In vitro antioxidant DPPH (1,1-diphenyl-2- picrylhydrazyl) and FRAP (Ferric reducing antioxidant power), antidiabetic α-amylase and α-glucosidase enzyme inhibitory assays were carried out on the extracts. Extracts of Syzygium polyanthum demonstrated better free radical scavenging and antidiabetic activity than Momordica charantia...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Saleha Sadeeqa, Mariam Maqsood, Maqsood Ahmad
Cardiovascular diseases are considered to be the leading cause of disability and deaths in the whole world. The major cause behind this disease is the formation of lipid plagues in the form of thrombus. The statins (HMG-CoA reductase inhibitors) are used for the treatment and prevention of hyperlipidemia. Myopathy is the major side effect caused by statins. The purpose of this study was to determine the prevalence of statin induced myopathy. A cross-sectional study design was adopted using convenient random sampling technique at Punjab Institute of Cardiology, Lahore Pakistan from November 2016 to February 2017...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Shamaila Zafar, Muhammad Mudassar Ashraf, Asghar Ali, Nosheen Aslam, Asma Ashraf, Sara Zafar, Rahat Andleeb, Muhammad Waqas Khadam, Imtiaz Mahmood Tahir, Muhammad Akram, Syed Muhammad Ali Shah, Muhammad Daniyal
Drug-drug interactions are most commonly occurring phenomenon in clinical practice. Many physicians are afraid of being involved in an allegation of malpractices due to the occurrence of any severe interaction. These interactions not only occur between drugs but also between any kind of food, tobacco smoke, caffeine and alcohol etc. Therefore, the present study was directed to inspect the effect of caffeine on the anticoagulation activity of warfarin in healthy adult male albino rabbits. Blank blood samples were collected from each rabbit...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Naureen Shehzadi, Khalid Hussain, Muhammad Islam, Nadeem Irfan Bukhari, Noman Asif, Muhammad Tanveer Khan, Muhammad Salman, Shaista Qamar, Sajida Parveen, Fakhra Zahid, Arshad Ali Shah, Abida Bilal, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Azizur Rehman
The present study describes the development and validation of a simple high performance liquid chromatographic method for the determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1, 3, 4-oxadiazole-2-thiol. The stability-indicating capacity of the method was evaluated by subjecting the compound's solution to hydrolytic, oxidative, photolytic, transition metal- and thermal- stress. The chromatographic separation was achieved over a C18 column (Promosil, 5 µm, 4.60 × 250 mm), maintained at 25°C, using an isocratic mobile phase comprising a mixture of acetonitrile and acidified water of pH 2...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Meng Zhao, Xiangqun Xu, Shaolong Yang, Tianming Liu, Bo Liu
The maltooligosyl trehalose synthase gene from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7 was cloned and the recombinant peotein was expressed in E. coli. The protein was purified to homogeneity by nickel column chromatography. The archaeal enzyme could catalyze an intramolecular transglycosylation reaction and convert the glycosidic bond at the reducing end of dextrins from α-1, 4 (reducing end) into α-1, 1 (non-reducing end). The most suitable temperature was 75°C and the optimal pH was 5...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Sajid Umar, Ana Triana Maiyah, Mehwish Shareef, Hajra Qadir, Qamarun Nisa, Seema Abbas
Antibiotic resistance in avian pathogenic Escherichia coli (APEC) is a common problem in the Indonesian poultry industry. Zoo birds have been postulated as sentinels, reservoirs, and potential spreaders of antibiotic resistance, although much is still unknown about the strains of zoo birds. Disinfection can reduce the infection burden. However, little is known about the presence of resistance against these products. Sixty one APEC strains were isolated from Indonesian zoo birds. The resistance to different classes of antibiotics as well as the minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of five disinfectants most often used in the poultry industry was determined...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Mansoor Ahmed, Mohsin Ali, Seyed Abdulmajid Ayatollahi, Marjan Esfahanizadeh, Farzad Kobarfard, Ameer Hasan, Khalid Mohammed Khan, Syed Moazzam Haider
During the past few decades the emergence of inorganic medicinal chemistry has been developed novel therapeutic agents. Researcher's perseverance in this branch of chemistry has led them to explore further valuable chemical spaces by synthesizing metal complexes already known pharmacological agents for their potential use. However, it is in its early stage, this methodology has demonstrated metal complexes with better bioactivities than the parent ligand molecules. In this study, transition metal complexes of pyrazinamide (PZ), isoniazid (INH), fluconazole (FCZ), metformin (dimethylbiguanide, DMBG) and losartan potassium (LS-K) were selected to evaluate for their possible anti-platelets aggregation in the light of reports on divalent and trivalent cations like calcium, copper, manganese, magnesium, and cadmium may influence the process of thrombocytic activity and aggregation...
March 2018: Pakistan Journal of Pharmaceutical Sciences
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