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Pakistan Journal of Pharmaceutical Sciences

Muhammad Kashif Riaz, Mohammad Riaz, Abida Latif
Medication errors occur every day causing injury to the patients and even deaths. The health care professionals are not fully aware of the damages done by medication errors in terms of patients' discomfort and economic burden. There is a need to provide information about medication errors to health care providers. This article reviews research done on the various aspects of medication errors. The research work done on prescribing errors, transcribing errors, dispensing errors, administration errors and discharged summaries errors have been examined...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Mingqing Peng, Chunbao Guo, Fang Gong, Min Li, Yuan Li, Qiang Peng, Lin Bo
The study aimed to investigate if the dynamic changes in cerebral electrical impedance (CEI) values could be used to monitor brain edema during cardiopulmonary bypass (CPB) in infants. Forty infants (mean age: 1.4±0.38y) with acyanotic congenital heart disease who underwent CPB open-heart surgery between September 2009 and March 2010 were prospectively enrolled, and divided into 2 groups based on aortic cross-clamping (ACC) time: CPB-A (ACC<50 min) and CPB-B (ACC<50 min). During the same period, twenty infants (aged 1-3y) who underwent surgery for indirect inguinal hernias were selected as controls...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Ahmad S Alkofahi, Khalid K Abdul-Razzak, Karem H Alzoubi, Omar F Khabour
Diabetes represents a group of common diseases that are characterized by dysregulation of blood glucose levels. Plants are traditionally used for management of diseases including diabetes. In this study, we screened the anti-diabetic effect of extracts of 21 plants grown in Jordan. Extracts of plants were screened for their antihyperglycemic activity. Diabetes was induced in Sprague Dawley rats using Alloxan. Plant extracts were dosed at 1gm/kg. Blood glucose was measured at baseline and at every hour for 3 hours...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Xueguo Chen, Dan Zhao
A robust gas chromatography-mass spectrometry method was utilized in the qualitative and quantitative analysis of designer drugs in human blood. Designer drugs, including methcathinone, 3, 4-methylenedioxymethcathinone, 4'-methyl-α-pyrrolidinopropiophenone and methylenedioxy-pyrovalerone were simultaneously analyzed by gas chromatography-mass spectrometry. Liquid-liquid small volume extraction was employed in the pretreatment of human blood sample, and the experimental results showed that the method was validated with high extraction efficiency, low limits of detection and good linearity throughout the studied concentration ranges...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Huma Ikram, Darakhshan J Haleem
Treatment-resistant depression is a major health problem worldwide. Restricted validity of the existing animal models of depression along with the need for the study of progressive development of resistance to antidepressants, demands the modeling of a progressive animal model of depression. Present study was designed to test the hypothesis that the repeated administration of reserpine could serve as a progressive animal model of depression. Animals were injected with reserpine (1.0mg/kg; once a day) for three weeks...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Sin Yeang Teow, Syed Atif Ali
This study evaluated the impact of pH (7.4 and 6.5), bovine serum albumin (BSA), and human serum albumin (HSA) on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus (S. aureus). Minimal inhibitory concentrations (MICs) of Curcumin against S. aureus were statistically indifferent (p>0.05) at pH7.4 and pH6.5. Activity of Curcumin against S. aureus was reduced by two folds in the presence of 1.25-5% BSA/HSA.
May 2017: Pakistan Journal of Pharmaceutical Sciences
Khizar Abbas, Ghazala H Rizwani, Hina Zahid, M Imran Qadir
The objective of the study was to investigate the nephroprotective activity of methanolic extract of different morphological parts (bract, flower, trachea and tracheal fluid) of Musa paradisiaca L. (Family: Musaceae) against gentamicin-induced nephrotoxicity in mice. Gentamicin produced significant changes in biochemical (increased levels of blood urea nitrogen level, blood urea, and serum creatinine), and histological parameters in mice. Treatment with methanolic extract of bract (100 and 250mg/kg, b.w) and flowering stalk (trachea) (250 and 500mg/kg, b...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Ghosia Lutfullah, Azizur Rahman, Aftab Ahmad, Taufiq Ahmad, Amjad Ali, Jan Alam
Present work is aimed to compare the physicochemical characterization and biochemical effects of oil extracted from Silybum Marianum and Sunflower oil, collected from Peshawar (Pakistan). To investigate the comparative effects on the body weight, organ weight and lipid profile, the crude oil of Silybum marianum, edible sunflower oil and vegetable ghee were given to three groups of rabbits under study. Percent proximate composition and food consumption of all rabbits were determined which showed no significant statistical variation...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Songwut Yotsawimonwat, Suporn Charumanee, Sayam Kaewvichit, Jakkapan Sirithunyalug, Panee Sirisa-Ard, Sirivipa Piyamongkol, Kulthawat Siangwong
Irvingia malayana wax (IW) is majorly composed of esters of medium chain fatty acids. Its melting point is low and closed to the body temperature. This study aimed at investigating the potential of IW as a matrix-forming agent and evaluate the effect of soluble channeling agents on the release of diclofenac sodium (DS) from IW matrix tablets. The preformulation study by infrared spectroscopy and differential scanning calorimetry showed no incompatibility between IW and DS or soluble channeling agents, namely PEG 4000, PEG 6000 and lactose...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Sabahat Jabeen, Fouzia Hassan, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Fozia Israr, S M Farid Hasan, Rehana Saeed, Sadaf Farooqi
Cefpodoxime proxetil is a third generation cephalosporin antibiotic demonstrates pH dependent solubility and is highly soluble only in acidic pH. The purpose of this investigation was to design and develop immediate release tablets of cefpodoxime proxetil by direct compression method and determine the effect of different solid buffers (organic acids) such as fumaric acid (formulations F1-F4), maleic acid (formulations M1-M4) and citric acid (formulations C1-C4) by using cefpodoxime and acid in the ratios of 4:1, 2:1, 1:1 and 1:2 to achieve pH-independent release of the drug...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Muhammad Naseem Khan, Hong Lin, Meng Li, Jingxue Wang, Zulfiqar Ali Mirani, Seema Ismat Khan, Muhammad Aslam Buzdar, Imran Ali, Khalid Jamil
Control of harmful bacteria in food, aquaculture, pharmaceuticals, agriculture, hospitals and recreation water pools are of great global concern. Marine bacteria are an enormous source of bio-controlling agents. The aim of this study was to identify and optimize the growth conditions including effect of different biotic and abiotic factors on antimicrobial activity of strain DK1-SA11 isolated from Qingdao Bay of China Yellow Sea. Microscopic characterization, API® 20E and 50 CHB kit base carbohydrates utilization, 16S rDNA and DNA gyrB gene sequencing studies identified the bacterium as Bacillus subtilis subsp...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Abd El-Galil E Amr, Mohamed A Al-Omar, Mohamed M Abdalla
In this work, twenty-one thiopyrimidine (1-21) candidates containing a pyrane, pyrazoline and thiazolopyrimidine ring screened for their ED50 and 5α-reductase inhibitors comparable to that of Anastrozole as positive drug. Some of the tested product showed moderate 5α-reductase inhibitors with lower toxicity. The detailed ED50 and 5α-reductase inhibitor activities of the synthesized compounds were studied.
May 2017: Pakistan Journal of Pharmaceutical Sciences
Mohsin Ali, Shah Aliul Qader, Faiza Shahid, M Saeed Arayne, Majid Mumtaz
The present paper deals with synthesis, characterization and amylase inhibitory activity of pyrazinamide (PYZ) with iron in its both (II) and (III) oxidation states. The synthesized complexes were characterized on the basis of IR, UV, (1)H-NMR, (13)C-NMR, elemental analysis and SEM. Changes in IR data shows that PYZ form complex with octahedral geometry and binding sites are ring nitrogen and carbonyl group, wherein two sides are satisfied with two chloride ions. SEM images indicate the crystalline state and surface morphology of PYZ and its complexes...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Iqbal A Muhammad Khyani, Masood A Qureshi, Talat Mirza, M Umar Farooq
Oral cancer is at rise in our population due to increasing use of areca nut (Betel nut) with or without tobacco. It is the second frequent malignant tumour for both the gender in Pakistan. This non-interventional case control study was carried out with the aim to explore saliva as diagnostic medium for detecting interleukins (IL) 6 and 8 as biomarkers of pre-malignant lesions (PML) and oral carcinoma. Total 105 subjects were recruited and were divided into three groups "A", "B" and "C" each comprising of 35 subjects...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Bo Hong, Wenjing Li, Miaoxian Dong, Yingcai Niu
Curdione is a main active component of curcuma rhizomes (Ezhu), which shows an excellent antithrombotic activity. In this study, the concentration of Curdione in pregnant rats and their offspring brain was determined using ultra-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UPLC-Q-TOF-MS) method. The water extraction then alcohol precipitation extract from Ezhu was administered through tail intravenous injection. The pharmacokinetic parameters were analyzed to compare the differences between the blood stasis group rats and normal group rats...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Sadaf Naeem, Rahila Ikram, Saira Saeed Khan, Sadia Saleem Rao
Parkinson's disease (PD) is a long-lasting neurodegenerative brain disease. It is characterized by a gradual decline in motor and non motor symptoms especially postural instability, tremors and memory impairment with localized loss of neurons mainly in the Substantia nigra. In the current research we evaluated the effects of Non-steroidal anti inflammatory drugs (NSAIDs) on motor coordination and memory in chlorpromazine (CPZ) induced Parkinson's experimental model. Intraperitoneal (i.p.) injection of CPZ (3 mg/kg) was given to all rats for 21 days to induce Parkinson like symptoms; ibuprofen (40mg/kg/day) and celecoxib (20mg/kg) were administered 30 minutes after CPZ injection...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Bilal Muhammad Khan, Jehan Bakht, Mohammad Shafi
The current research investigates the anti-microbial activities of different solvent extracted samples from the leaves of Calamus aromaticus against Gram positive, Gram negative bacteria and fungi using 500, 1000 and 2000 μg disc(-1) concentrations. Escherichia coli, Citorbacter freundii and Candida albicans showed resistivity to crude methanolic extract and the same microbes were more susceptible to water extracted fractions. Maximum activity was measured by hexane extracted fractions against Pseudomonas aeruginosa, Bacillus subtilis and Xanthomonas campestris and minimum growth inhibition by water extracted fractions...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Gunpreet Kaur, Vikas Gupta, Ajay Francis Christopher, Renu Bansal, Parveen Bansal
Bacterial resistance to antibiotics is increasingly becoming a concern to public health. Current antibiotics have failed to bring desirable results to many bacterial infections due to multi-resistant strains. So, concerted efforts are being made to curve this with the help of dietary phytohemicals. A number of dietary phytochemical are being put to trials for antimicrobial activity; however it is worthwhile to search such a part of diet that is very frequently used by major population. Keeping this view in mind an effort has been made to evaluate the antimicrobial activity of most common vegetable component Allium cepa...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Tahira S Khokhar, Shahabuddin Memon, Qadeer K Panhwar, Fakhar N Memon, Ayaz A Memon, Muhammad Qasim Samejo, Saba Muneer, Metin Tulu
Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. δG, ΔH and δS have been found as -24...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Sajjad Hussain, Ghulam Murtaza, Ansar Mehmood, Rizwana Aleem Qureshi
The aim of present was to document indigenous knowledge of medicinal plants traditionally used by inhabitants of Rawalakot Azad Kashmir and to screen selected medicinal plants for their antibacterial potential. Several field surveys were conducted to document indigenous knowledge of medicinal plants through interviews from local inhabitants during 2010-2013. During the study, 58 plant species, belonging to 37 families, were identified and their medicinal uses were recorded. Ethnobotanical data indicates that inhabitants of Rawalakot use medicinal plant mainly for the treatment of stomach, liver and sexual disorders...
May 2017: Pakistan Journal of Pharmaceutical Sciences
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