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Pakistan Journal of Pharmaceutical Sciences

Jiangtao Cheng, Chuanyu Gao, Yuhao Liu, Zhongmin Wang, Xiaohui Zheng, Datun Qi
To compare and analyze the effect and the safety of the paclitaxel-eluting stents and paclitaxel-eluting balloon in the treatment for in-stent rest enosis. 120 cases, who had been undergone percutaneous coronary intervention (PCI) in the Department of Cardiology of Henan Provincial People's Hospital from January 2012 to January 2014 were selected. All the patients were randomly treated with paclitaxel-eluting balloon or paclitaxel-eluting stents. The former were divided into different groups that named group A and the later group B...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Farah Zeb, Sabira Naqvi, Razaur Rahman, Ahsana Dar Farooq
Depression is one of the leading causes of disability in developing countries including Pakistan. This study was designed to assess the frequency and severity of depressive symptoms, monoamines and their metabolite levels, MAO-B activities before and after treatment with antidepressants in a sub-set of Karachi population in Pakistan. Drug naive depressed subjects were evaluated before and after treatment with selective serotonin reuptake inhibitors. Symptoms of depressed mood and anxiety psychic (90%) were more frequent whereas, suicidal thoughts (~50%) and feelings of guilt (~30%) were less common...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Yuehui Su, Mengzhen Zhang, Weiwei Zhang, Huirong Shi
This paper aims to investigate the clinical curative effect and adverse reactions of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. 100 cases diagnosed with chronic cervicitis complicated with HPV infection from August 2014 to August 2015 in our hospital were selected and randomly divided into observation group (50 cases) and control group (50 cases). The preoperative and postoperative HPV-DNA changes were observed, and the vaginal discharge, time of decrustation and hemostasis, HPV negative conversion ratio and clinical efficacy were compared, to record the adverse reactions during treatment...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Guangli Sun, Gang Su, Yanhui Bai, Huiqin Yang
To explore the treatment method and preventive measures on epidemic keratoconjunctivitis. 108 patients with epidemic keratoconjunctivitis who received treatment in our hospital from January, 2015 to September, 2015.were selected. These patients were treated with interferon eye drops, Ganciclovir ophthalmic gel, and alternating eye treatment of tobramycin-dexamethasone eye drops and diclofenac sodium eye drops. Meanwhile, health education was also performed among patients, so as to promote the recovery of the disease as soon as possible and to prevent the spread of the disease Among the 108 patients, there were 101 patients recovered...
July 2017: Pakistan Journal of Pharmaceutical Sciences
HaiLi Wang, Chuchu Wang, Lei Sun, Shiyuan Zhou, Fengyu Wang
To investigate the effect of bilateral oophorectomy on bone mineral density, body composition and sex hormone of peri-menopause women. 33 cases of peri-menopause women patients performed bilateral oophorectomy were chosen from xxx gynaecology and obstetrics department of xxx hospital from January 1st,2014 to Dec31th, 2014. And the 33 cases were taken as ovariectomy group. 35 women who were the naturally postmenopausal after menopause collected in clinic and in the same period with the patients of ovariectomy group were taken in control group...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Ning Ma, Hua-En Xu, Zhifen Luo, Jianwei Zhou, Yun Zhou, Mingyue Liu
This paper aims to determine the expression and clinical significance of DDX43 in lung adenocarcinoma. Expression of DDX43 gene and protein of lung adenocarcinoma tissue and para-carcinoma tissues was observed in 27 cases by RT-PCR and immunohistochemistry. These patients were diagnosed as lung adenocarcinoma in the Huaihe Hospital of Henan University from February 2015 to December 2015. The relative ratio of DDX43 mRNA expression in lung adenocarcinoma and para-carcinoma tissues was 0.87±0.62 versus 0.21±0...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Mirza Tasawer Baig, Ali Akbar Sial, Ambreen Huma, Maryam Ahmed, Uzma Shahid, Nayel Syed
This study assessed the prescribing pattern of irrational use of antibiotic among children under age of 12 years in public and private sector hospitals in Pakistan. The prospective clinical evaluation of drug utilization pattern of antimicrobials from Patient Bedside File (PBF) of in-patients and Culture Sensitivity Test (CST) reports were evaluated to determine the antibiotic resistance. Two indicators recorded to assess antibiotic prescribing were; dose of prescribed antibiotic (low-dose, rational and high -dose) and Indication (valid or invalid)...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Lijuan Wei, Jinsong Zhang, Lixiao Zhou
This paper aimed to evaluate the clinical application value of vitrectomy combined with intraocular drug injection on treatment of severe endophthalmitis. Retrospective analyzed the 28 eyes for the 28 cases of patients suffering severe endophthalmitis, and with treatment of pars plana vitrectomy combined with intraocular drug injection, and foreign matter removal surgery. This study also analyzed the whole body and local application of antibiotics data, and clinical data of corticosteroid drug treatment. This study had followed up 6 to 12 months, 28 intraocular infected eyes of the 28 cases all had got controlled...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Jingge Chen, Yumin Cheng, Xinxiang Ma, Yuanyuan Cao
This paper aims to observe the effect of Shenqi Fuzheng Injection combined with cefoxitin sodium after cesarean section. Clinical data of 126 puerperae were retrospectively analyzed. They randomized into control group and treatment group, and there were 63 cases in each group. Patients in control group were given Cefoxitin Sodium treatment. And patients in treatment group were given Shenqi Fuzheng Injection on the basis of control group. After 7 days of treatment, the clinical curative effect of the two groups was observed and compared...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Yuxiao Yuan
The objective of this paper is to study the global DNA Methylation in monozygotic (MZ) twins with cerebral palsy. Two pairs of twins (a cerebral palsy children, a normal child) admitted to the First Affiliated Hospital of Zhengzhou University were selected as subjects. The phenol-chloroform method was used to extract DNA from venous blood and micro satellite DNA genotyping technique was used to identify the eggs of the twins. DNA methylation fragments were enriched by MBD affinity column chromatography, followed by Solexa sequencing and bioinformatics analysis...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Tingting Li, Yanyan Hao, Yu Zhu
This paper aims to observe the relevance of 24-hour intraocular pressure (IOP) monitoring and water drinking test (WDT) in patient with primary open angle glaucoma (POAG). 55 patients (90 eyes) with POAG was selected and randomly divided into operation group and drug group. Operation group, with 30 cases (48 eyes), were treat with trabeculectomy. And the other 25 cases (42 eyes) were treated with antiglaucoma medication. 24-hour intraocular pressure and WDT were measured before treatment and 6 months after treatment...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Huimin Zhang, Juan Sun, Haiyang Zhang, Yuhua Zhu, Xujie Mao Xujie Mao, Fang Ai, Siyuan Tang, Rong Li
This paper aims to understand the blood pressure control status for hypertension patients, and discuss the relationship between social support, medication compliance and blood pressure for hypertensive patients. The survey objective was the hypertensive patients in chronic disease management system in Xinxiang city. The survey was conducted as the questionnaire survey filled by objectives. Social support rating scale and medication therapy compliance questionnaire was utilized to evaluate the patients' social support and medication therapy compliance...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Bing Han, Hua Li, Qiaoli Ma
Aim of the present study is to investigate the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) and dopamine combination treatment in patients with cardiorenal syndrome type 4 (CRS4) combined with hypotension. A total of 160 CRS4 patients admitted to our hospital from July 2010 to December 2014 were recruited, and were randomly divided into two groups, the observational group (n=80) and the control group (n=80). CRS4 patients treated with dopamine were recruited into the control group...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Li Zhang, Na Liu, Jinying Zhang, Hui Zhang, Ying Zhang
Aim of the present research work was to study the relationship between the degree of dementia and the serum levels of homocysteine(Hcy), high-sensitive C-reactive protein(hs-CRP), D-Dimer and vascular dementia(VaD) of patients, and to investigate the mechanism of Hcy, hs-CRP and D-Dimer in the vascular dementia. Subjects were divided into normal group and VaD group. CRP and D-Dimer protein of each sample were detected by nephelometry method, and the serum Hcy level was detected by Fluorescent labeling immunoassay method...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Neli-Kinga Olah, Daniela Benedec, Sonia Socaci, Claudia Crina Toma, Lorena Filip, Claudiu Morgovan, Daniela Hanganu
The Rosemary (Rosmarinus officinalis L.), a well-known medicinal and culinary herb, was studied to compare the terpenic profile of different extracts obtained from dry and fresh herb. There were studied the volatile oil extracted by hydro distillation from dry plant, the hydroalcoholic extracts obtained from fresh respectively dry plant and the glycerol macerate obtained from fresh plant, by GC-MS using headspace injection. The separated compounds were identified using a MS spectra library. The quantitative determination was performed by normalization respectively by calibration curve method for 1,8-cineole, alpha-pinene and D-limonene...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Noreen Samad, Farzana Yasmin, Suad Naheed, Abu Zeeshan Bari, M Mazhar Ayaz, Aqal Zaman, Atif Akbar, Saima Saeed, Najeeb Ullah
Obesity is an important risk factor for sleep disorders. This study aimed to evaluate the association of leptin, zinc and tryptophan (TRP) in obese subjects with sleep deficits [sleep apnea (SA), insomnia (IN)]. In this cross sectional case control, with the verbal and written consent 206, obese with sleep deficits and 30, non-obese/normal identified from various areas of Karachi, Pakistan. The socio-demographic data including; age, body mass index (BMI), education and residence, of participants was collected...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Jie Xu, Feng Li, Fengling Chang
This paper aims to 137 cases of breast malignant tumors confirmed by surgery and pathology were collected. All patients received ultrasound examination and were not treated by radiotherapy or chemotherapy before operation. The preoperative ultrasound images of breast cancer patients and postoperative pathological characteristics of paraffin sections were retrospectively observed. Ultrasound indicators included tumor size, shape, ratio of the longest/shortest dimension, edge of the spiculation and peripheral hyperechoic halo sign, internal echo types, micro calcification, posterior echo types, blood flow and signs of lymph node metastasis...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Segueni Narimane, Evren Demircan, Akkal Salah, Beraat Özçelik Ozcelik, Rhouati Salah
We aimed in the reported study to investigate the impact of using various solvents in the extraction of potentially active compounds from Algerian propolis. Phenolic and flavonoids contents in association with antioxidant activity of the tested extracts were evaluated. Moreover phenolic composition was determined using UFLC-MS/MS. The tested parameters varied according to the used solvent. Total phenolic and flavononid contents ranged from 0.81±0.16 to 8.97±0.25 EGA mg/g and from 0.57±0.01 to 3.53±0.84 EQ mg/g respectively...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Yanping Zhu
To investigate the changes of tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) in the serum and their effects on organ function in patients with severe acute pancreatitis (SAP) during infected stage, aiming to provide a reference to individual treatment. 32 patients with SAP during infected stage admitted to the Digestive Department of The Second Affiliated Hospital of Zhengzhou University from April 2014 to May 2015 and also 30 volunteer normal people were recruited in this study. And 26 patients detected with positive pathogenic bacteria were grouped into group A and another 6 patients with negative pathogenic bacteria into group B and 30 normal people into group C...
July 2017: Pakistan Journal of Pharmaceutical Sciences
Masoud Parsania, Mohammad-Bagher Rezaee, Seyed Hamidreza Monavari, Kamkar Jaimand, Seyed Milad Mousavi-Jazayeri, Mehdi Razazian, Mohammad Hossein Nadjarha
Herpes simplex virus type 1 (HSV-1) causes serious infections particularly in immunocompromised patients. Methanolic extract of four plants were evaluated for their anti-viral effects against acyclovir resistant HSV-1 in HeLa cell line. The 50% cytotoxic concentration (CC50) as well as the effective minimal cytotoxic concentration of each plant extract were evaluated by MTT assay. Antiviral effects of the plant extracts on HSV-1 were examined at different concentrations of the extract. The effective minimal cytotoxic concentration was evaluated at different times of virus replication after infection...
July 2017: Pakistan Journal of Pharmaceutical Sciences
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