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Pakistan Journal of Pharmaceutical Sciences

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https://www.readbyqxmd.com/read/28167485/expression-of-th17-and-cd4-cd25-t-regulatory-cells-in-peripheral-blood-of-acute-leukemia-patients-and-their-prognostic-significance
#1
Mingli Xiang, Li Guo, Yan Ma, Yi Li
To discuss the expression of T helper cell 17 (Th17) cells and CD4+ CD25+ Foxp3+ regulatory T cells (Treg) in peripheral blood (PB) of patients with acute leukemia (AL), and to explore the relationship between them and disease prognosis. 40 patients diagnosed with acute leukemia in The First Affiliated Hospital of Zhengzhou University from July 2012 to August 2014 were selected as the observation group. Meanwhile, 40 healthy people were taken as the control group. Flow Cytometry Method (FCM) was used to detect the level of Th17 cells and CD4(+) CD25(+) Foxp3(+) cells in peripheral blood of the two groups, and enzyme-linked immuno sorbent assay (ELISA) method was used to test the level of IL17 and TGF-β in peripheral blood of two groups; reverse transcription-polymerase chain reaction (RT-PCR) was adopted to analyze the mRNA levels of RORγT and Foxp3 in peripheral blood...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167484/anti-proliferative-and-apoptosis-inducing-potential-of-hydroalcoholic-achillea-wilhelmsii-c-koch-extract-on-human-breast-adenocarcinoma-cell-lines-mcf-7-and-mda-mb-468
#2
Hamid Reza Galavi, Ramin Saravani, Ali Shahraki, Mojtaba Ashtiani
Achillea wilhelmsii C. Koch contains a variety of components such as flavonoid. The previous studies showed that flavonoid has anti-cancer properties. The aim of the present study was to determine the anti-proliferative and apoptosis-inducing potential of hydroalcoholic Achillea wilhelmsii C. Koch extract (HAWE) on MCF-7 and MDA-Mb-468 human breast carcinoma cell lines. The anti-proliferative activity of HAWE was evaluated using MTT, flowcytometry by annexin V/PI double staining, and caspase-3 activity. The results of MTT showed that the ED50 of MCF-7 and MDA-Mb-468 was 25μg/ml of HAWE, 48h after treatment...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167483/quercetin-inhibits-human-sperm-functions-by-reducing-sperm-ca2-i-and-tyrosine-phosphorylation
#3
Xiaolei Liang, Zhili Xia, Jiexi Yan, Yiqing Wang, Shilong Xue, Xuehong Zhang
Quercetin is widely known as potent natural antioxidant and scavenger of reactive oxygen species (ROS) and nitric oxide both in vitro and in vivo. Quercetin has a wide range of biological functions and health-promoting effects. There are more and more interests in the addition of this flavonol to various traditional food products. However, the in vitro toxicity of quercetin to mature human sperm remains unknown. In this study, we investigated the in vitro effects of quercetin on human sperm functions. The results showed that the total sperm motility were significantly inhibited compared to the controls following exposure to 100, 200 and 400µM quercetin for 6 and 12h; quercetin did not affect human sperm viability...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167482/beneficial-effects-of-sitagliptin-and-metformin-in-non-diabetic-hypertensive-and-dyslipidemic-patients
#4
Mazhar Hussain, Moazzam Ali Atif, Muhammad Bilal Ghafoor
Obesity, dyslipidemia and hypertension are major risk factors for cardiovascular disease and its associated complications. To evaluate the beneficial effects of sitagliptin and metformin in non-diabetic dyslipidemic and hypertensive patients. A prospective randomized clinical trial was conducted on 70 newly diagnosed dyslipidemic patients with BMI > 25 and blood pressure > 130/80 at outpatient clinic of medical unit-1 of Sheikh Medical College/Hospital, Rahim Yar Khan. They were divided in to three groups each containing 35 patients; First group served as a healthy control while second and third study groups were given tablet sitagliptin 50mg and tab metformin 850mg respectively twice a day for twelve weeks...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167481/3-chloromethylene-6-fluorothiochroman-4-one-a-novel-dna-topoisomerase-poison
#5
Yitian Wang, Juntao Chen, Rui Shen, Chunliu Yang, Zhengyue Ma, Yuxin Liu
3-Chloromethylene-6-fluorothiochroman-4-one (CMFT) is a novel thiochromanones derivative that has better anti-tumor activity. In this paper, we will compare the antitumor activity of the cis-trans isomers, and explore their inhibiting effects on human topoisomerase I and topoisomerase II in cell free reaction system. The MTT method was used to study inhibition rates; the AO/EB double staining and TUNEL assay was used to assess proportion of apoptotic cells. The inhibition of CMFT to Topo I and II could be identified by adding CMFT solutions to Topo-DNA reaction mixtures and observing the relative quantities of relaxed strands and supercoils in electrophoresis assay...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167480/effect-of-total-flavonoids-of-scutellaria-barbata-on-cognitive-function-and-nogo-a-expression-in-the-hippocampus-in-cerebral-ischemia-model-in-gerbils
#6
Yanping Zhang, Yanmei Li
To explore the effect of total flavonoids of Scutellaria barbata on cognitive function and nogo-A expression in the hippocampus region in cerebral ischemia model in gerbils. 30 gerbils were randomly divided into model group, sham operation group, large dose of total flavonoids of Scutellaria barbata group (large dose group), middle dose of total flavonoids of Scutellaria barbata group (middle dose group) and small dose of total flavonoids of Scutellaria barbata group (small dose group), with 6 cases in each group...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167479/evaluation-on-curative-effect-and-safety-of-interventional-treatment-for-patients-with-acute-myocardial-infarction
#7
Yinchuan Zhu, Jianmin Tang, Feifei Pei
To evaluate the effectiveness and recent safety of emergency and selective percutaneous coronary intervention (PCI) in elderly patients (>80 years old) with acute myocardial infarction (AMI). 120 elderly patients with coronary heart disease (CHD) were divided into AMI group (with 55 cases) and non-myocardial infarction group (control group with 65 cases). Among the AMI group, there were 18 cases underwent emergency PCI within 12 hours after the onset, (AMI emergency PCI group), the rest 37 cases were AMI selective PCI group...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167478/the-study-of-polyphenolic-compounds-profile-of-some-rosmarinus-officinalis-l-extracts
#8
Neli-Kinga Olah, Gyongyi Osser, Ramona Flavia Câmpean, Flavia Roxana Furtuna, Daniela Benedec, Lorena Filip, Oana Raita, Daniela Hanganu
The purpose of this study was to compare the polyphenol profile of different Rosemary (Rosmarinus officinalis) extracts obtained from dry and fresh herb and the evaluation of their antioxidant effect. There were studied the polyphenols from hydroalcoholic extracts (1:5- dry plant:solvent) obtained from fresh respectively dry plant and the gemmotherapic extract obtained from fresh plant (1:20- dry plant: solvent). The polyphenol profile was evaluated by UV-Vis spectrophotometry, TLC and HPLC. The total polyphenol respectively flavonoids content were determined by UV-V is spectrophotometry...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167477/efficacy-and-safety-of-entoban-for-the-treatment-of-chronic-diarrhea
#9
Sadia Shakeel, Khan Usmanghani, Hafiz Muhammad Asif
The current randomized clinical trial was conducted to assess the safety and effectiveness of Entoban for treating patients of chronic diarrhea. The study enrolled 150 patients fulfilling the inclusion criteria, among them 95 were males and 55 were females. Written informed consent was obtained from all study participants. Metronidazole tablets (400 mg) were used in a control group for 7-10 days. The test group received Entoban capsule 400mg every 8 hours for five days. Primary outcome of the study was daily bowel frequency evaluation; the secondary outcome was evaluation of clinical symptoms including abdominal pain, distention, stool consistency and sensation of incomplete evacuation...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167476/research-on-the-influence-factors-of-the-fall-efficiency-of-the-hospitalized-geriatric-patients-with-cerebrovascular-diseases
#10
Weili Li, Ruilian Cheng
To investigate the fall efficiency and its influence factors of the hospitalized geriatric patients with cerebrovascular diseases. The Modified Fall Efficacy Scale (MFES), Morse Fall Risk Assessment Scales (MFS), Berg Balance Scale (BBS) and Tinetti Gait Analysis (TGA) were adopted and the combined ways of questionnaires and observation were utilized to investigate the 113 hospitalized geriatric patients with cerebrovascular diseases. The fall efficiency of the geriatric patients with cerebrovascular diseases were 7...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167475/evaluation-of-acute-toxicity-sedative-and-analgesic-effects-of-taverniera-glabra-methanolic-extract-on-mice
#11
- Marvi, Javeid Iqbal, Shafi Muhammad, Mansoor Ahmad
Present study was conducted on crude methanolic extract of stem and root of Taverniera glabra. In Pakistan T. glabra is found in the region of Balochistan only. T. glabra has numerous therapeutic uses in traditional medicine and it is also used for the pain relief. Current study was carried out to evaluate acute toxicity, analgesic and CNS depressant activity of the plant. Acute toxicity was carried out by oral administration of the T. glabra extract from 250 to 2000mg/kg oral dose. Analgesic activity was carried out by acetic acid induced writhing test and formalin test...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167474/regulatory-effect-of-caspase-11-on-interleukin-1%C3%AE-in-the-fungal-keratitis
#12
Keke Zhu, Hongmei Mu, Baimu Pi
Caused by fungus, fungal keratitis is a kind of infections corneal disease with high rate of blindness, which patients are mainly farmers in developing countries. Interleukin, as important proinflammatory cytokines, involve in immune defense process against fungal infection of cornea. The expression of interleukin in the pathogenesis of fungal keratitis, especially the main source of its cells, is not clear and the cell signaling pathways which regulate the synthesis and modification of interleukin is still unknown...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167473/therapeutic-effect-of-atorvastatin-on-kidney-functions-and-urinary-excretion-of-glimepiride-in-healthy-adult-human-male-subjects
#13
Tayyaba Sana, Bilal Aslam, Nosheen Aslam, Muhammad Mudassar Ashraf, Asma Ashraf, Tahir Aqeel Malik, Sammia Gul Niazi, Imtiaz Mahmood Tahir, Muhammad RiazurRehman, Hamad Ahmed
Glimepiride and atorvastatin in combination are commonly employed for treating the hyperglycemia and dyslipidemia, respectively, in patients of type 2 diabetes. The present study was designed to find out the influence of atorvastatin on urinary excretion and renal clearance of Glimepiride in healthy adult male volunteers. In each experimental subject, Glimepiride 2mg was given orally after an overnight fasting. Samples of blood and urine were taken at different specific time intervals. After a washout period of ten days, Glimepiride 2mg was co-administered with atorvastatin 20mg orally...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167472/mri-and-clinical-manifestations-of-delayed-encephalopathy-after-carbon-monoxide-poisoning
#14
Xiahong Wang, Zhenyu Li, Jacqueline Berglass, Wenlong He, Jianmin Zhao, Min Zhang, Chongyang Gao, Caixia Zhang, Huimin Zhang, Xuewei Yi
To explore the relationship between the clinical manifestations and functional magnetic resonance images of delayed encephalopathy after carbon monoxide intoxication. Six patients received the MRI were diagnosed with delayed encephalopathy after carbon monoxide (CO) poisoning. Clinical manifestations were observed in each patient. MRI revealed multiple lesions. The majority of the lesions were located in the globus pallidus, sub cortical white matter, and basal ganglia. The cognitive injury, akinetic mutism, fecal and uroclepsia, forced crying, forced laughing and extra pyramidal syndromes such as chorea and parkinsonism were manifested in clinic...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167471/effect-of-viscum-schimperi-on-advanced-glycation-endproducts-formation
#15
Hossam Mohamed Abdallah, Doha Omar ALGhamdi, Maab Siddiq Al-Salem, Maryam Alattas, Hany Mohamed El-Bassossy, Abdulrahman Mohammed Alahdal, Ibrahim Ateya Shehata, Essam Abdel-Sattar
Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts (AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167470/effect-of-shexiang-baoxin-pills-on-clopidogrel-resistance-in-patients-with-acute-coronary-syndrome
#16
Li Zhang, Na Liu, Jinying Zhang, Hui Zhang
To explore the effect of Shexiang baoxin pills on clopidogrel resistance in patients with acute coronary syndrome (ACS). 131 cases with ACS combining with clopidogrel resistance admitted to our hospital during March 2013 to November 2015 were recruited in this study and were divided into observation group (66 cases) and control group (65 cases) according to the random number table method. And the patients in observation group were given clopidogrel with Shexiang baoxin pills therapy while the control group clopidogrel therapy to observe the platelet aggregation rate, heart rate variability (HRV), and serum level of matrix metalloproteinase-2 (MMP-2)...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167469/relationship-of-oxidative-stress-with-elevated-level-of-dna-damage-and-homocysteine-in-cardiovascular-disease-patients
#17
Muhammad Qasim, Shazia Anwer Bukhari, Madiha Javeed Ghani, Muhammad Shareef Masoud, Tayyabah Huma, Muhammad Arshad, Asma Haque, Zubair Ibrahim, Sadia Javed, Muhammad Ibrahim Rajoka
Amounts of DNA damage and homocysteine (Hcy) in heart patients blood may have strong function in the causation of cardiovascular disease (CVD). The main objective of this work was to know experimentally the role of total oxidants (produced by Reactive Oxygen species (ROS), clinical biochemical indices, their oxidized products and total antioxidant status (TAS) among such patients to find the association of homocysteine, total oxidation status (TOS) and oxidative DNA damage with other clinical parameters in sixty positive CVD patients compared with those of 60 normal subjects...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167468/the-study-of-early-intravenous-nutrition-therapy-in-very-low-birth-weight-infants
#18
Lang Dongming, Zhou Fengran, Zhang Zhaojun
To analyze the clinical effect of early intravenous nutrition therapy for very low birth weight infants. 80 cases of very low birth weight infants referred to our hospital from June 2013 to June 2015 were randomly and evenly divided into two groups. The infants in group A were treated with early intravenous nutrition, while with late parenteral nutrition for those in group B. The intravenous nutrition time, proportion of body weight loss, time consumption for recovery to birth weight and full enteral nutrition and complication rate between the two groups were compared...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167467/clinical-efficacy-and-safety-of-herbal-medicine-dermidoc-in-the-management-of-atopic-dermatitis-versus-allopathic-medicine-polymixinb-bacitrin-ointment
#19
Muhammad Osama Alam, Ejaz Mohiuddin, - Shahab-Ud-Din, Muhammad Daniyal, Khan Usmanghani
Atopic dermatitis (AD) commonly identified as eczema. AD is an inflammatory, long-lasting, highly pruritic reverting disease of the skin. AD is classified by disease of outer skin layer barrier function. AD is progress with Immunoglobulin E facilitated sensitization to food and environmental allergens. One study stated that more than 59.6% of teen-agers with AD are at high risk of develop asthma or rhinitis. Interaction between genes and environment increase the prevalence of AD. AD have three standard stages: infantile, childhood, and adulthood...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28167466/the-curative-effect-analysis-and-nursing-measures-of-the-transvaginal-myomectomy-and-transabdominal-myomectomy
#20
Lingping Meng, Wanxia Li
To analyze the curative effects of the transvaginal myomectomy (TVM) and the traditional transabdominal myomectomy (TAM). The group with traditional TAM received routine preoperative nursing guidance and postoperative care. While the group with TVM received preoperative strengthened psychological care, vaginal preparation and postoperative strengthened vagina nursing, paying attention to the prevention and treatment of complications, and maintaining effective pelvic draining and other nursing measures. After that, the statistical processing and analysis were used to compared the intraoperative blood loss, operating time, postoperative infusion time, hospitalization time, postoperative eating, postoperative ambulation, the usage rate of postoperative analgesic, postoperative morbidity and postoperative complications between the two groups Comparison between TVM group and TAM group showed that the difference of the operating time, postoperative infusion time, hospitalization time, postoperative eating, postoperative ambulation, the usage rate of postoperative analgesic, postoperative morbidity and postoperative complications between the two groups were statistically significant (P<0...
November 2016: Pakistan Journal of Pharmaceutical Sciences
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