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Pakistan Journal of Pharmaceutical Sciences

Li-Wei Xue, Xiao Chen, Dan-Dan Yin, Xu-Xia Wang
Small cell neuroendocrine carcinoma (SCNEC) of the tongue is very rare. We here present a SCNEC impatient with distant metastasis. A 74-year-old Chinese male went to hospital to treat a tongue tumor, which was founded at a conventional physical examination in Weifang Stomatology Hospital. The check of positron emission tomography-computer tomography (PET-CT) by Weifang people's hospital revealed a tumor in the right root of tongue, and distant metastasis in the right submandibular area, neck, mediastinum, right hilar, abdominal, retroperitoneal multiple lymph nodes, left thyroid, right lower lung, right scapula and bilateral adrenal...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Yuhang Sun, Xiaohui Dong, Guofeng Zhang, Jing An, Haojun Yuan
The oral and maxillofacial region is rich in blood, and it is often difficult to stop bleeding during the operation of maxilla. Nitroglycerin is one of the most commonly used antihypertensive drugs in our hospital. We observed the effect of controlled hypotension in patients with maxillary resection. In group N, the patients had different degrees of tachycardia after using nitroglycerin only. In addition, nitroglycerin has the characteristics of rapid drug resistance. A combined reversed temporal muscle flap and random forehead flap technique was performed successfully to reconstruct the large defect after ipsilateral maxillectomy and orbit evisceration...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Jianguang Cai, Muhammad Aqeel Ashraf, Limei Luo, Hui Tang
This paper aims to observe and analyze effects of Codonopsis pilosula water extract on micro RNA (miRNA) expression profile in liver tissue of senile mice. The 110 Konminmice were randomly divided into five groups, including D-galactose-induced senile model group, normal control group, and low, middle and high dose intervention groups. Continuous modeling lasted 40 days. General symptoms and changes of body mass of the model mice were monitored and observed. The levels of serum glutamic pyruvic transaminase (ALT) and alkaline phosphatase (ALP) of mice were compared, and miRNA of differential expression during aging of D-galactose-induction and high-dose Codonopsis pilosula intervention was analyzed...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Jing An, Xingqi Chen, Yuhang Sun
Pentoxifylline is widely used in the treatment of cerebrovascular disease, at present, there are a variety of drugs in the clinical expansion of the role of the skin flap, by improving or promoting blood circulation, to ensure the survival of the flap. We designed scalping forehead flap to reconstruct large temporal cutaneous defects. This flap is reliable and can give us excellent postoperative result. This design has several advantages and is worth to be promoted. The scalping forehead flap we designed is reliable...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Chenghui Shao, Shuangshuang Xu, Yang Song, Dong Zhu
This paper based on the theory of radiopharmaceuticals and the theory of radiation risk prediction, the author mainly studies the dose distribution of F-FDG and its radiation risk. Through the assessment of the risk of radiation carcinogenesis, the effective dose range was 4.61mSv to 8.97mSv, and the range of radiation carcinogenic risk was 1.57 ×10(-3)-3.14×10(-3). Also, we reviewed the development trend of medical image processing techniques, and the development of medical imaging processing in three-dimensional (3D) medical imaging visualization and PACS-based medical imaging compression is introduced...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Jinyong Tao, Yanxia Wang
This study was designed to investigate the efficacy and safety of endoscopic submucosal dissection (ESD) for treatment of early gastric cancer. In this study, we evaluated the effects of antithrombotic drugs on bleeding risk in patients with ESD. Meta analysis showed that the use of antithrombotic drugs before ESD can reduce the risk of postoperative bleeding, but the early recovery of the use of antithrombotic drugs, or combined with a variety of antithrombotic drugs will increase the risk of bleeding. Twenty-four lesions in 524 patients were treated using ESD, and treatment status and efficacy were observed...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Jiang Hui
This paper was aimed to analyze whether the U.S. strict export control to China affects the technological innovation of Chinese pharmaceutical industry. This paper selected the data of technological innovation and the expenditure of high and new technology adoption in China's pharmaceutical industry from 1995 to 2014, created panel regression model to study the impact of export controls on technology spillovers and the impact of technology spillovers on innovation capacity. The results show that US export control has a significant impact on technology spillovers, but foreign technology spillovers have no significant impact on the innovation of Chinese pharmaceutical industry...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Zheng Wang, Lian Liu, Xiaoxin Jiang, Hui Zhou, Yong Zeng, Leping Zeng
With the abuse of antibiotics, pathogenic bacteria more resistant to infection, prevention and control of postoperative, we conducted a systematic analysis of the pathogenic bacteria and drug resistance in patients with infection after surgery. At the same time, we evaluate long-term outcomes between laparoscopy-assisted and open approaches to total gastrectomy for upper gastric cancer. Overall survival (OS) and disease-free survival (DFS) was evaluated using the Kaplan-Meier method. We matched all 246 laparoscopic cases 1:1 with open cases according to age, sex, body mass index and clinical TNM stage...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Dinghui Zheng, Xian Yang
The effect of citrate to Desloratadine Citrate Disodium set in the treatment of chronic urticaria in patients with IL4, IL18, and IL23, IL33 levels was investigated. 100 cases of chronic urticaria treated in our hospital from January 2013 to January 2015 were divided into study group and control group by random number table method. Patients in the study group with chloric thunder of citric acid treatment, the control group were treated with mizolastine in the treatment, the treatment time for 2 weeks. The difference of curative effect between the two groups and the changes of IL4, IL18, IL23, IL 33 before and after treatment in two groups were compared...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Li Jia, Jiang Yongmei, Peng Leiwen, Yang Yi
The purpose of the present research was to establish reference intervals for renal function indexes (Cystatin C, Blood Urea Nitrogen Creatinine and Uric Acid) in pregnant women in China. Blood samples were collected from 203 healthy non-pregnant women and 623 healthy pregnant women in different trimesters. Samples from 23 healthy consecutive pregnant women were collected to validate. Serum Cystatin C was measured by latex particle enhanced immune turbidity assay (Dade Behring, Germany) using Centaur 2400 (Siemens, New York, USA)...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Hao Chen, Qing Zhou, Jinlian Liu
To analyze and evaluate the clinical efficacy of the combination of locking plate and anti-osteoporosis drug for the patients with senior osteoporotic proximal humerus fractures. 120 patients with senior osteoporotic proximal humerus fractures were selected as research objects. According to the differences of treatment options, they were divided into two groups, i.e., 60 patients in observation group accepting the treatment of combination of locking plate and anti-osteoporosis drug, the other 60 patients in the control group accepting simple locking plate treatment...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Chen Zhao, Jiaqi Zhao, Wanying Wang, Yening Fan, Chunping Ma, Donghong Zhang, Yang Lv
To construct the pIRES2-MLAA34-HSP70 recombinant vector and express the MLAA34-HSP70 recombinant proteins in Escherichia coli (E. coli). The MLAA34 and the HSP70 genes were extracted from U937 cells by RT-PCR, and then we amplified the fusion gene MLAA34-HSP70 by SOE-PCR and inserted it into the pIRES2-EGFP vector to construct the pIRES2-MLAA34-HSP70 recombinant vector. We amplified the fusion gene MLAA34-HSP70 successfully and identified the correctness of pIRES2-MLAA34-HSP70 recombinant vector by PCR and restriction endonuclease...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Ma Quanqing
In this study of long term curative effect of chronic obstructive pulmonary disease in remission stage treated with TCM, we have selected 79 patients from January 2013 to January 2015 in our hospital with chronic obstructive pulmonary disease as the research object, we have divided into observation group (40 cases) and control group (39 cases) randomly, the control group received routine treatment, observation group received TCM pulmonary rehabilitation therapy, compare pulmonary function and clinical curative effect of 2 groups of patients, and dyspnea index (Brog index), blood oxygen saturation after 6 and 12 months' treatment...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Yongsheng Xu, Jing Ning, Zhulai Zhang
Pertussis infection can mimick the clinical manifestations of lower airway infection, while the symptoms and signs in some cases are like Bronchiolitis. The paper carried out retrospective analysis of infant pertussis bordetella infected cases admitted by the Respiratory Dept. of Tianjin Children's Hospital for "capillary bronchitis" from Sept. 2015 to Feb. 2016. It analyzed its clinical features, radiological features, laboratory characteristics and outcome through comparing the capillary bronchitis cases induced by the non-bordetella pertussis...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Song Lili, Zhao Song
This paper was aimed to further analyze the concrete clinical efficacy of dezocine as an anesthetic for peritoneal gynecology operation and to offer a scientific guidance for future surgical treatments. This paper randomly selected 1000 peritoneal gynecology operation patients in 5 hospitals from January to December 2015 as research objects in the observation group, who were mainly applied with dezocine in operative anesthesia. By analyzing data of cases, it concluded efficacy characteristics of dezocine in various phases, and thus provide scientific guidance for future surgical treatments...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Wen Yu
This study is to analyze the effects and variations on cognitive function for elderly patients undergoing general thoracic surgery, who accepted the anesthesia with propofol and sevoflurane. A total of 500 elderly general thoracic surgical patients were selected randomly, all receiving the propofol anesthesia (Propofol group). Meanwhile, another totality of 500 patients in the same condition and period were selected and accepted the sevoflurane anesthesia (Sevoflurane group). Mini-mental state examination (MMSE) and recovery quality after anesthesia were compared among the patients in both groups respectively at the time of pre-operation and 1 h, 6 h and 12 h after surgery...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Akebaier Sulaiman, Xuefeng Wan, Junwei Fan, Hadiliya Kasimu, Xiaoyang Dong, Xiaodong Wang, Lijuan Zhang, Paride Abliz, Halmurat Upur
The paper is intended to analyze and evaluate the specific curative effect and safety of 2% liranaftate ointment in treating patients with tinea pedis and tinea cruris. 1,100 cases of patients with tinea pedis and tinea corporis & cruris were selected as research objects and were divided into two groups according to the random number table method. They were treated with different methods: 550 cases of patients were treated with 2% liranaftate ointment for external use in the observation group and the rest 550 cases of patients were treated with 1% bifonazole cream in the control group...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Wen Li, Cunfang Ban, Junxia Zhang, Yingying Hu, Bingjuan Han, Bingchao Han
Cough variant asthma (CVA), as one of bronchitis diseases, features with repeated cough. In clinics, CAV does not show significant abnormal signs, therefore antibiotic therapy can hardly achieve satisfactory treatment effect. With the development of scientific technologies, the correlation between mycoplasma pneumoniae infection and CVA has become a hot research topic in clinics. In clinics, mycoplasma pneumoniae is extensively regarded as major cause for CVA, with complex pathogenic mechanism. The symptoms of CVA is characterized by chronic non abnormal inflammation, normally accompanied with bronchospasm and intestinal infection...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Yi Zeng, Kai Huang, Weiwei Huang
The purpose of the present research work was to study the CYP2D6 gene polymorphism survival outcome after breast cancer patient received the toremifene and tamoxifen treatment. Seventy-eight patients who received radical mastectomy and toremifene and tamoxifen treatment after operation were divided into three groups: CYP2D6*1/*1 group (13 cases), CYP2D6*1/*10 group (28cases) and CYP2D6*10/*10 group (35 cases), according to the gene polymorphism of blood serum CYP2D6. The results of treatment of three groups were compared...
May 2017: Pakistan Journal of Pharmaceutical Sciences
Yanting Geng, Yuanhui Hu, Huan Wang, Shuai Shi, Jingjing Shi, Zhiling Qiu
Mitochondrial dysfunction plays an important role in the progress of heart failure (HF). A pronounced variability of defects in mitochondrial subpopulations is reported to occur in various disease models. The aim of the study was to define the defects in the ultra structure and bioenergetic function of cardiac mitochondria in acute myocardial infarction-induced HF. AMI-induced HF rats were treated with saline (4.0ml/kg) for 8weeks. The ultra structure of myocardial mitochondrial subpopulations was assessed by electron microscope...
May 2017: Pakistan Journal of Pharmaceutical Sciences
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