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Veterinary Dermatology

Ichiro Imanishi, Shinpei Hattori, Junzo Hisatsune, Kaori Ide, Motoyuki Sugai, Koji Nishifuji
BACKGROUND: Impetigo is a bacterial skin disease characterized by intraepidermal neutrophilic pustules. Previous studies have demonstrated that exfoliative toxin producing staphylococci are isolated in the cutaneous lesions of human and canine impetigo. However, the mechanisms of intraepidermal splitting in impetigo remain poorly understood. OBJECTIVE: To determine how staphylococci penetrate the living epidermis and create intraepidermal pustules in vivo using a mouse model of impetigo...
November 13, 2016: Veterinary Dermatology
Elizabeth A Mauldin, Ping Wang, Thierry Olivry, Paula S Henthorn, Margret L Casal
BACKGROUND: Plectin, a large linker protein found in many tissues, acts to connect components of the cytoskeleton to each other. In the epidermis, plectin binds keratin intermediate filaments to hemidesmosomes. A deficiency of plectin in the skin leads to blister formation in the basal layer and the disease epidermolysis bullosa simplex (EBS). HYPOTHESIS/OBJECTIVES: To describe a novel blistering disease that arose spontaneously in a litter of puppies. ANIMALS: Two female and one male 20-day-old Eurasier puppies, from a litter of six, were presented for evaluation of failure to thrive and then euthanized due to poor prognosis...
November 7, 2016: Veterinary Dermatology
Bruna Meyrer, Simone Passos Bianchi, Saulo Petinatti Pavarini, Daniel Guimarães Gerardi
BACKGROUND: Melanocytic tumours are derived from melanocytes and are common in older dogs with dark pigmented skin. Primary congenital cutaneous melanoma has been described in domestic mammals although there are no reports in the dog. HYPOTHESIS/OBJECTIVE: We describe a case of canine congenital cutaneous melanoma with rapid progression to metastasis and death. ANIMAL: A male, mixed breed dog was born with a circular ulcerated lesion near the left ear...
November 4, 2016: Veterinary Dermatology
Gila Zur, Bella Gurevich, Daniel Elad
BACKGROUND: Antimicrobial resistance within bacteria continues to present therapeutic challenges. One presumed risk factor for increased rates of resistance is prior exposure to antimicrobial drugs. OBJECTIVES: To examine the impact of time since most recent exposure, the number of prior antimicrobial exposures and duration of use on antimicrobial resistance rates in Staphylococcus pseudintermedius isolates. METHODS: Inclusion of a case in the study required laboratory isolation of S...
December 2016: Veterinary Dermatology
Hock Siew Han, Chiara Noli, Tiziana Cena
BACKGROUND: Lynxacarus radovskyi has been observed in cats in Malaysia; previously treatment with fipronil and moxidectin/imidacloprid spot-on has been described. OBJECTIVES: To compare the efficacy of two spot-on treatments of moxidectin/imidacloprid, two weeks apart to a single oral dose of fluralaner against Lynxacarus radovskyi and evaluate time to re-infestation. METHODS: Thirty cats were assigned to three groups of ten cats each. Group 1 received one 250 mg fluralaner tablet...
December 2016: Veterinary Dermatology
Kenneth W Kwochka
No abstract text is available yet for this article.
December 2016: Veterinary Dermatology
Frane Banovic, Keith E Linder, Maarja Uri, Michael A Rossi, Thierry Olivry
BACKGROUND: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized. HYPOTHESIS/OBJECTIVES: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE. METHODS: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis)...
December 2016: Veterinary Dermatology
Gina M Michels, Deborah S Ramsey, Kelly F Walsh, Olivier M Martinon, Sean P Mahabir, Jacquelien D Hoevers, Rodney R Walters, Steven A Dunham
BACKGROUND: Pruritus is the hallmark clinical sign of atopic dermatitis (AD) in dogs. Lokivetmab, a caninized anti-canine IL-31 monoclonal antibody, reduced pruritus and associated inflammatory skin lesions in a proof-of-concept study in dogs with AD. HYPOTHESIS/OBJECTIVES: The objective was to describe lokivetmab dose response in a randomized, double blind, placebo-controlled trial. ANIMALS: Clinicians at 15 referral clinics enrolled 211 client owned dogs with a history of chronic AD...
December 2016: Veterinary Dermatology
Gina M Michels, Kelly F Walsh, Kristina A Kryda, Sean P Mahabir, Rodney R Walters, Jacquelien D Hoevers, Olivier M Martinon
BACKGROUND: Lokivetmab (ZTS-00103289) is a caninized anti-canine IL-31 monoclonal antibody that has demonstrated efficacy in reducing pruritus associated with atopic dermatitis (AD) in dogs in field trials. HYPOTHESIS/OBJECTIVES: This study evaluated the safety of lokivetmab in a randomized, double blind, placebo-controlled trial in client owned dogs with AD with minimal restrictions on concomitant medications and co-morbidities. ANIMALS: Clinicians at 14 veterinary clinics enrolled client owned dogs (n = 245) with chronic AD...
December 2016: Veterinary Dermatology
Catherine A Outerbridge, Stephen D White, Verena K Affolter
OBJECTIVE: To describe a case of testicular neoplasia and alopecia universalis in a dog, and successful treatment of the latter with ciclosporin. ANIMAL: Twelve-year-old intact male wirehaired fox terrier. METHODS: Castration, skin biopsy for histopathology, lymphocyte immunophenotyping and clonality analysis of the canine T-cell receptor gamma locus (TCRγ) rearrangement. RESULTS: The dog presented with symmetrical generalized alopecia...
December 2016: Veterinary Dermatology
Steve Bexton, Helen Nelson
BACKGROUND: Dermatophytosis caused by Trichophyton erinacei is a common scaling and crusting skin disease affecting European hedgehogs (Erinaceus europaeus) admitted to wildlife rescue centres. The application of topical therapy can be challenging because wild hedgehogs are subject to stress and often roll into a ball when handled. Systemic antifungal therapy is more convenient but has not been evaluated in this species. HYPOTHESIS/OBJECTIVES: To compare the efficacy of oral itraconazole versus oral terbinafine for the treatment of dermatophytosis affecting hedgehogs...
December 2016: Veterinary Dermatology
Jennifer J Bentley, Domenico Santoro, Dunbar W Gram, Mauricio Dujowich, Rosanna Marsella
BACKGROUND: The environment is important in transmission of bacteria. Textiles are difficult and time consuming to clean; ultraviolet light C (UVC) is germicidal and may be an effective disinfection method for textile surfaces. OBJECTIVE: This study evaluated the efficacy of UVC, a commercial quaternary ammonium compound antimicrobial spray (FAS) and UVC+FAS combined for reducing bacterial colonization on experimentally contaminated textiles. METHODS: Microfibre, cotton and polyester were inoculated with meticillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA), Staphylococcus pseudintermedius (MSSP and MRSP), Pseudomonas aeruginosa or Escherichia coli...
December 2016: Veterinary Dermatology
Chiara Caporali, Francesco Albanese, Diana Binanti, Francesca Abramo
BACKGROUND: Feline paraneoplastic alopecia (FPA) is a rare condition listed among the cutaneous paraneoplastic syndromes, which occurs in association with pancreatic carcinoma, cholangiocarcinoma, hepatocellular carcinoma and metastatic intestinal carcinoma. OBJECTIVES: To describe the clinicopathological findings of paraneoplastic alopecia in two cats each with an uncommon tumour not previously reported in association with FPA. ANIMALS: Paraneoplastic alopecia was associated with neuroendocrine pancreatic neoplasia in a Persian cat and with a hepatosplenic plasma cell tumour in a domestic short hair cat...
December 2016: Veterinary Dermatology
Emmanuel Bensignor, Lionel Fabriès, Lucie Bailleux
BACKGROUND: Bacterial pyoderma is a frequent presentation in dogs. Despite the widespread availability of effective systemic and topical antimicrobial products, good clinical practice currently recommends avoidance of long-term use to mitigate the development of bacterial resistance. HYPOTHESIS/OBJECTIVES: To evaluate the speed of resolution of clinical signs of bacterial pyoderma in dogs treated with a systemic antimicrobial agent with or without the use of an adjunctive spray with antimicrobial properties...
December 2016: Veterinary Dermatology
Fiona F Lee, Charles W Bradley, Christine L Cain, Stephen D White, Catherine A Outerbridge, Lisa A Murphy, Elizabeth A Mauldin
BACKGROUND: Although zinc responsive dermatosis is typically a disorder of Arctic breed dogs, this study identifies similar cutaneous lesions on the face and pressure points of Boston terrier dogs. HYPOTHESIS/OBJECTIVES: To document the clinical and histological features of localized parakeratotic hyperkeratosis of Boston terrier dogs, to determine if the lesions respond to zinc supplementation and to determine whether tissue zinc levels were decreased in affected versus unaffected dogs...
October 2016: Veterinary Dermatology
Lyn M Wise, Christa J Bodaan, Andrew A Mercer, Christopher B Riley, Christine L Theoret
BACKGROUND: Wounds in horses often exhibit sustained inflammation and inefficient vascularization, leading to excessive fibrosis and clinical complications such as "proud flesh". Orf virus-derived proteins, vascular endothelial growth factor (VEGF)-E and interleukin (ovIL)-10, enhance angiogenesis and control inflammation and fibrosis in skin wounds of laboratory animals. HYPOTHESIS/OBJECTIVES: The study aimed to determine if equine dermal cells respond to VEGF-E and ovIL-10...
October 2016: Veterinary Dermatology
Yasmine H Tartor, Hend M El Damaty, Yasser S Mahmmod
BACKGROUND: Rapid and accurate identification of dermatophytes is crucial for the effective control of disease outbreaks. Current methods based on culture and microscopic characteristics may require weeks before positive identification is made. OBJECTIVES: To (i) identify the most common pathogenic dermatophytes affecting Arabian horses; (ii) compare the performance of direct microscopy (DM), culture, PCR using hair samples (PCRhair ) and PCR based on culture isolates (PCRculture ) for the diagnosis of dermatophytosis...
October 2016: Veterinary Dermatology
Giovanni Ghibaudo, Davide Santospirito, Andrea Sala, Sara Flisi, Simone Taddei, Sandro Cavirani, Clotilde Silvia Cabassi
BACKGROUND: Pseudomonas aeruginosa (PA) may cause suppurative otitis externa with severe inflammation and ulceration in dogs. Multidrug resistance is commonly reported for this organism, creating a difficult therapeutic challenge. OBJECTIVE: The aim of this study was to evaluate the in vitro antimicrobial activity of a gel containing 0.5 μg/mL of antimicrobial peptide AMP2041, 0.07% chlorhexidine digluconate (CLX), 0.4% Tris and 0.1% EDTA on 30 clinical isolates of PA from canine otitis externa...
October 2016: Veterinary Dermatology
Camilo Romero, Rafael Heredia, Jocelyn Pineda, Jonathan A Serrano, Germán D Mendoza, Porfirio Trápala, Alberto M Cordero
BACKGROUND: There are few licensed options for the treatment of canine sarcoptic mange. OBJECTIVE: To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation. ANIMALS: Seventeen dogs with a diagnosis of Sarcoptes scabiei based on positive skin scrapings. METHODS: A single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month...
October 2016: Veterinary Dermatology
Vincent Bruet, Henri Dumon, Patrick Bourdeau, Jean-Claude Desfontis, Lucile Martin
BACKGROUND: The diagnosis of canine atopic dermatitis (CAD) remains challenging due to the lack of a simple biomarker or metabolic profile. In human medicine, Fourier transform infrared spectroscopy (FTIR) is an analytical technique used for several diseases. It requires a small amount of sample and allows the identification of structural moieties of biomolecules on the basis of their infrared absorption, with limited sample pretreatment. HYPOTHESIS/OBJECTIVES: The aim of the study was to evaluate the diagnostic value of FTIR...
October 2016: Veterinary Dermatology
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