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Veterinary Dermatology

Frane Banovic, Jaime Tarigo, Hannah Gordon, James P Barber, Robert M Gogal
BACKGROUND: Oclacitinib is a Janus kinase inhibitor used to control pruritus and skin lesions in canine allergic skin disease; its effect on canine T cells is not well-characterized. HYPOTHESIS/OBJECTIVES: To evaluate the impact of oclacitinib on cultured T cells using peripheral blood mononuclear cells from dogs. ANIMALS: Six bluetick coonhounds. METHODS AND MATERIALS: Lymphocyte-enriched cells were incubated with or without the T-cell mitogen concanavalin A (Con A), oclacitinib (0...
November 12, 2018: Veterinary Dermatology
Jennifer Bexley, Nicola Kingswell, Thierry Olivry
BACKGROUND: In humans, a cross-reactive clinical allergy has been reported between three chicken and fish meat proteins: beta-enolase, aldolase A and parvalbumin. OBJECTIVE: To evaluate if IgE cross-reactivity between chicken and fish also existed in the dog. ANIMALS: Sera from dogs with suspected allergic skin disease and with IgE against chicken and fish. METHODS AND MATERIALS: Sera were analysed by ELISA and immunoblotting with chicken, white fish (haddock and cod) and salmon extracts...
October 30, 2018: Veterinary Dermatology
Mary Beth Spitznagel, Meghan Solc, Kimberly R Chapman, John Updegraff, Angela L Albers, Mark D Carlson
BACKGROUND: Skin disease in companion animals often requires long-term management which may contribute to caregiver burden in the dermatology client. HYPOTHESES/OBJECTIVES: We expected greater caregiver burden in dermatology clients relative to healthy control veterinary clients and that no difference would be present between healthy controls and dermatology clients reporting good skin disease control. Within the dermatology sample, we hypothesized that greater caregiver burden would correlate with client perception of the animal's severity of disease (ASD), animal skin disease quality of life (ASD-QoL), and client general quality of life (CG-QoL) and skin disease-related quality of life (CSD-QoL)...
October 29, 2018: Veterinary Dermatology
Lissandro G Conceição, Fabiana R Araújo, Fabricia H Loures, Virginia V Zanuncio
No abstract text is available yet for this article.
October 14, 2018: Veterinary Dermatology
Xiumin Chen, Yifeng Yang, Baozeng Xu, Haijun Wei
No abstract text is available yet for this article.
October 4, 2018: Veterinary Dermatology
Courtney Meason-Smith, Caitlin E Older, Roxanna Ocana, Brandon Dominguez, Sara D Lawhon, Jing Wu, Adam P Patterson, Aline Rodrigues Hoffmann
BACKGROUND: The pathogenesis and treatment of cutaneous malodour in dogs have not been investigated previously. Staphylococcus and Corynebacterium spp. are associated with human axillary malodour. HYPOTHESIS: Staphylococcus and Corynebacterium spp. are associated with cutaneous malodour in dogs, and treatment with a topical essential oil-based product will improve malodour and reduce the abundance of odour-causing bacteria. ANIMALS: Twenty seven bloodhound dogs from a south Texas boarding facility were enrolled in this study...
September 24, 2018: Veterinary Dermatology
Julius J Mwanandota, Mercy Macharia, Chanasa M Ngeleja, Raphael S Sallu, Mmeta G Yongolo, Charles Mayenga, Timothy A Holton
BACKGROUND: Lumpy skin disease (LSD) is caused by LSD virus which is a member of the Capripoxvirus (CaPV) genus. Although PCR provides for a rapid and sensitive diagnosis, it has limited use due to its complexity in terms of cost, time and equipment. Loop-mediated isothermal amplification (LAMP) is a simple, specific and cost-effective method with a diagnostic accuracy similar to PCR. OBJECTIVES/HYPOTHESIS: To compare the detection rate (DR) of two LAMP assays versus PCR for the detection of CaPV...
September 24, 2018: Veterinary Dermatology
Seulgi Bae, Kijung Kim, Taeho Oh
BACKGROUND: Canine atopic dermatitis (cAD) is associated with an imbalance between multiple T lymphocytes and cytokines. Ex vivo boosted immune cell (EBIC) therapy is the sequential administration of ex vivo cultured and activated lymphocytes to patients to improve immune function. OBJECTIVE: This pilot study aimed to assess the safety of EBIC therapy and demonstrate its efficacy as a novel treatment for cAD. ANIMALS: Ten dogs with AD. METHODS AND MATERIALS: The phenotypes of the immune cells before and after ex vivo culture were analysed by flow cytometry...
September 18, 2018: Veterinary Dermatology
Dario d'Ovidio, Emilio Noviello, Domenico Santoro
BACKGROUND: Exotic companion mammals are popular pets worldwide. They are a potential source of zoonotic infections transmissible to their owners. HYPOTHESIS/OBJECTIVES: To determine the prevalence and zoonotic risks of tropical rat mite (Ornithonyssus bacoti) in exotic companion mammals in Italy. ANIMALS: The records of 782 exotic pet mammals seen in multiple veterinary clinics (n = 20), pet shops (n = 10) and private breeders (n = 2) around Naples (Italy) were searched...
September 6, 2018: Veterinary Dermatology
Anette Loeffler, Desiree Herrick, Serena Allen, Janet D Littlewood
BACKGROUND: Allergic pruritus and urticaria in the horse are challenging for veterinarians and owners; little is known about their long-term management. OBJECTIVES: To summarize intradermal allergen test results (IDT), and to assess owners' perceptions of skin disease and the effects of medical treatment and management changes in their atopic horses over time. ANIMALS: Eighty two horses with atopic dermatitis in southeastern England between 2006 and 2011...
September 3, 2018: Veterinary Dermatology
Stephanie B Abrams, Guy N Brock, Marilly Palettas, Michelle L Bolner, Tricia Moore-Sowers, Greg A Plunkett, Lynette K Cole, Sandra F Diaz, Gwendolen Lorch
BACKGROUND: Limited information is available for dogs on threshold concentrations (TCs), and the protein composition of common allergenic extracts produced by different manufacturers. HYPOTHESIS/OBJECTIVES: To characterize the protein heterogeneity of tree, grass, weed and mite allergens from different lots of allergenic extracts, and to determine intradermal TCs for healthy dogs using extracts from two manufacturers. ANIMALS: Twenty five privately owned, clinically healthy dogs and ten purpose-bred beagle dogs...
September 3, 2018: Veterinary Dermatology
Miho Ikeuchi, Ryota Asahina, Hidetaka Nishida, Hiroaki Kamishina, Katsuya Kitoh, Hiroki Sakai, Sadatoshi Maeda
BACKGROUND: In canine epitheliotropic cutaneous T-cell lymphoma (ECTCL), neoplastic cells cause skin lesions and potentially metastasize to lymph nodes, blood and other organs. Murine models are potentially valuable for elucidating the molecular mechanisms responsible for regulation of ECTCL cell migration. HYPOTHESIS/OBJECTIVES: To describe a phenotype of mice xenografted with canine ECTCL cells (EO-1 cells). ANIMALS: Four NOD.CB17-Prkdcscid /J (NOD SCID) mice were used...
August 30, 2018: Veterinary Dermatology
Clarissa P Souza, Jennifer R Schissler, Elena T Contreras, Steven W Dow, Leone S Hopkins, Jonathan W Coy, Rod A W Rosychuk, Jennifer R Hawley, Michael R Lappin
BACKGROUND: Juvenile onset generalized demodicosis (JOGD) is thought to occur due to immunological abnormalities and is over-represented in pit bull terrier-type dogs. ANIMALS: Twelve pit bull terrier-type dogs with JOGD and 12 age-matched healthy pit bull terrier-type dogs. OBJECTIVE: To investigate immunological differences between age-matched healthy and JOGD pit bull terrier-type dogs by flow cytometry, multiplex, molecular and serological assays...
August 23, 2018: Veterinary Dermatology
Clarissa P Souza, Rod A W Rosychuk, Elena T Contreras, Jennifer R Schissler, Andrew C Simpson
BACKGROUND: Lokivetmab neutralizes IL-31, a cytokine that plays an important role in the pathogenesis of atopic dermatitis (AD) in dogs. OBJECTIVE: To review experience of one year of treatment with lokivetmab for the control of pruritus in dogs with allergic dermatitis. ANIMALS: Eighty dogs diagnosed with AD, ten with concurrent adverse food reaction and AD and 45 with allergic dermatitis of undetermined cause. Three dogs were lost to follow- up...
August 23, 2018: Veterinary Dermatology
Brittany L Southern, Pradeep Neupane, Marna E Ericson, Jamie C Dencklau, Keith E Linder, Julie M Bradley, Gabriel P McKeon, Charles T Long, Edward B Breitschwerdt
BACKGROUND: Bartonella henselae, a Gram-negative, zoonotic, alpha-proteobacteria has been previously implicated in association with cutaneous vasoproliferative lesions (bacillary angiomatosis), nodular panniculitis and multifocal erythema (erythema multiforme) in dogs. OBJECTIVE: Describe clinical, microbiological and histological lesions in a dog with ear margin vasculitis and B. henselae infection. ANIMALS: A 12-month-old, specific pathogen-free intact female beagle dog maintained in a vector-free laboratory animal resource facility...
December 2018: Veterinary Dermatology
Ana Rostaher, Nina M Fischer, Adrian Urwyler, Claude Favrot
BACKGROUND: The pathogenesis of canine atopic dermatitis (cAD) is characterized immunologically by an imbalanced T-cell response. Mechanisms of immune regulation in cAD have not yet been completely elucidated. OBJECTIVES: To investigate peripheral blood T regulatory (Treg) cells and their associated cytokines (TGF-β and IL-10) in an experimental model of cAD. ANIMALS: Eight beagle dogs that were initially naïve and subsequently sensitized to house dust mites (HDM)...
December 2018: Veterinary Dermatology
Magdalena Siemieniuk, Katarzyna Sosnowska, Jan Czerniecki, Urszula Czyzewska, Katarzyna Winnicka, Adam Tylicki
BACKGROUND: Malassezia pachydermatis is an opportunistic yeast involved in skin and ear canal infections of dogs and cats. Reports suggest that strains of M. pachydermatis resistant to commonly used antifungal agents may be emerging. Therefore, new therapeutic strategies should be explored. OBJECTIVES: The synergistic effect of oxythiamine (OT) and ketoconazole (KTC) was analysed using a reference strain and field isolates (n = 66) of M. pachydermatis. Hydrogel formulations containing these components also were evaluated...
December 2018: Veterinary Dermatology
José-Luis González, Vicente Zalve, Enrique Fernández-Caldas, Bárbara Cases, José-Luis Subiza, Miguel Casanovas
BACKGROUND: Polymerized allergoids coupled to nonoxidized mannan (PM-allergoids) are novel allergen preparations used for immunotherapy. OBJECTIVE: To evaluate PM-allergoids as an alternative immunotherapy for dogs with canine atopic dermatitis (cAD) associated with serological responses to Dermatophagoides farinae allergens. ANIMALS: Sixteen dogs with history and clinical signs of cAD; positive on serum allergen specific IgE testing to D...
October 2018: Veterinary Dermatology
Irina Matricoti, Chiara Noli
BACKGROUND: The diagnosis of adverse food reaction (AFR) is based on an eight week elimination diet (ED) and is confirmed by relapse upon re-challenge with the previously fed diet. Hydrolysed EDs are commonly used for this purpose. OBJECTIVE: To evaluate a commercially available hydrolysed fish protein and rice starch ED for the diagnosis of AFR. ANIMALS: Fifty nonseasonally pruritic dogs. METHODS AND MATERIALS: Pruritus was assessed with a Visual Analog Scale, lesions with the Canine Atopic Dermatitis Lesions Index and quality of life with a validated questionnaire on days 0 and 56...
October 2018: Veterinary Dermatology
Maria K Ierace, Michael S Canfield, Jeanine Peters-Kennedy, Curtis W Kane
BACKGROUND: Squamous cell carcinoma (SCC) is the most commonly reported neoplasm of the nasal planum and treatment is focused on localized disease. Rostral maxillectomy and/or nasal planectomy are considered standard of care for excision of nasal planum SCC; however, the cosmetic outcome of these procedures can be deemed unacceptable by many pet owners. OBJECTIVES: The study aim was to evaluate the efficacy of combination carbon dioxide (CO2 ) laser surgery and cryosurgery as a palliative treatment modality in dogs with nasal SCCs...
October 2018: Veterinary Dermatology
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