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Veterinary Dermatology

Amanda Blubaugh, Daniel Rissi, Deborah Elder, Tara Denley, Sitka Eguiluz-Hernandez, Frane Banovic
BACKGROUND: Topical Janus kinase (JAK) inhibition is a promising therapeutic target for several inflammatory skin diseases of humans. OBJECTIVES: To evaluate the anti-inflammatory effect of tofacitinib, a JAK 1/3 inhibitor, on immediate and late-phase skin reactions in dogs. ANIMALS: Five healthy laboratory beagle dogs. METHODS: Topical tofacitinib (total daily dosage: 0.5 mg/cm2 ) or its gel vehicle were applied on either the left or right lateral thorax of each dog for eight days...
March 6, 2018: Veterinary Dermatology
Ryota Asahina, Hidetaka Nishida, Hiroaki Kamishina, Sadatoshi Maeda
BACKGROUND: In humans, interleukin (IL)-33 plays a critical role in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL-33 is involved in the pathogenesis of canine atopic dermatitis (cAD). OBJECTIVES: To examine the expression of IL-33 in chronic lesional skin of cAD. ANIMALS: Eight dogs with spontaneous cAD and five healthy dogs were used. METHODS: The transcription of il-33 in chronic lesional skin of cAD was quantified by quantitative reverse transcription PCR...
March 2, 2018: Veterinary Dermatology
Britt J Levy, Douglas J DeBoer
BACKGROUND: Cross-reactive carbohydrate determinants (CCD) are defined carbohydrate portions of glycoprotein cell surface molecules common to many plant and insect species. Mammalian species recognize CCD as foreign antigens and can mount humoral immune responses against them. Approximately 20-37% of grass and venom allergic people possess circulating IgE against CCD; these antibodies are generally considered clinically irrelevant. Anti-CCD IgE is, however, recognized as a cause of false positive, clinically incongruent serum allergen test results in people; this phenomenon has not been investigated in animals...
March 1, 2018: Veterinary Dermatology
Marion Mosca, Murielle Vabret, Pia Randleff-Rasmussen, Didier Pin
BACKGROUND: The horn fly Haematobia irritans is known to cause problems in cattle including weight loss and decreased milk production; cutaneous lesions have not been widely reported and descriptions of the clinical manifestations are quite variable. HYPOTHESIS/OBJECTIVES: This study describes the clinical and histopathological lesions of several Aubrac cows that presented with focal to confluent areas of alopecia, skin scaling and thickening, suspected to be induced by H...
March 1, 2018: Veterinary Dermatology
Kayleigh E Mitchell, Jane F Turton, David H Lloyd
BACKGROUND: Acinetobacter species can exhibit widespread resistance to antimicrobial agents. They are already recognized as important nosocomial pathogens of humans, but are becoming increasingly recognized in opportunistic infections of animals. HYPOTHESIS/OBJECTIVES: This study aimed to determine whether Acinetobacter spp. are carried on skin of healthy dogs and, if present, to identify the species. ANIMALS: Forty dogs were sampled at veterinary practices and rescue centres...
February 11, 2018: Veterinary Dermatology
Lena L M N Zwickl, Deborah E Joekel, Nina M Fischer, Ana Rostaher, Kristian Thamsborg, Peter Deplazes, Claude Favrot
BACKGROUND: Total IgE concentrations are higher in dogs than in humans. Persistent Toxocara canis larval infection is prevalent in dogs and is associated with substantial specific antibody reactions. A correlation, however, between total IgE and T. canis-specific antibody levels in dogs has not been evaluated. OBJECTIVES: To determine the relationship between total IgE, T. canis-specific IgG and IgE, and allergen-specific IgE levels in atopic and non-atopic dogs, and to evaluate possible confounding factors...
February 9, 2018: Veterinary Dermatology
Lerpen Duangkaew, Lawan Larsuprom, Pojnicha Anukkul, Chalermpol Lekcharoensuk, Charles Chen
BACKGROUND: Generalized demodicosis in dogs can be challenging to manage, especially in adult-onset cases. HYPOTHESIS/OBJECTIVES: This study evaluated the efficacy of oral fluralaner at the dose of 25-50 mg/kg for the treatment of canine generalized demodicosis. ANIMALS: Client-owned dogs from Bangkok, Thailand, diagnosed with generalized demodicosis according to published criteria. METHODS: Deep skin scrapings were performed at three to five affected areas to evaluate numbers of mites...
February 8, 2018: Veterinary Dermatology
Csilla Becskei, Otto Cuppens, Sean P Mahabir
BACKGROUND: Treatment of canine demodicosis can be challenging; new treatments are always being sought. OBJECTIVE: The efficacy of sarolaner was evaluated in comparison with a moxidectin/imidacloprid topical product against generalized demodicosis in dogs in a randomized, single-masked, multi-centre field study. ANIMALS: Client-owned dogs were treated monthly with oral sarolaner (n = 53) or with weekly/monthly topical moxidectin/imidacloprid (n = 28)...
February 8, 2018: Veterinary Dermatology
Stephanne L Schwartz, Anthea E Schick, Thomas P Lewis, Diana Loeffler
BACKGROUND: Prolonged sun exposure in high ambient temperatures has been recognized as a cause of thermal burns on the dorsal skin of dogs, termed dorsal thermal necrosis (DTN). HYPOTHESES/OBJECTIVES: To characterize the clinical presentation, histopathology and outcomes of 16 dogs diagnosed with DTN and to identify associated risk factors. ANIMALS: Sixteen dogs diagnosed with DTN. METHODS: Medical records from 2009 to 2016 were reviewed retrospectively...
February 1, 2018: Veterinary Dermatology
Ramón M Almela, Camila P Rubio, José J Cerón, Agustina Ansón, Alexander Tichy, Ursula Mayer
BACKGROUND: Oxidative stress (OS) has been shown to be involved in the pathogenesis of human and canine atopic dermatitis (AD) through several distinct mechanisms. Selected serum biomarkers of OS (sbOS) have been validated in normal dogs and studied in several canine diseases. To the best of the authors' knowledge, the sbOS evaluated in this study have not previously been described in canine AD. HYPOTHESIS/OBJECTIVES: The aims of the study were to evaluate a panel of sbOS in dogs with food-induced (FIAD) and non-food-induced (NFIAD) AD: cupric reducing antioxidant capacity (CUPRAC), ferrous oxidation-xylenol orange (FOX), ferric reducing ability of the plasma (FRAP), paraoxonase-1 (PON1), trolox equivalent antioxidant capacity (TEAC) and serum total thiol (THIOL)...
February 1, 2018: Veterinary Dermatology
Csilla Becskei, Otto Cuppens, Sean P Mahabir
BACKGROUND: Various treatments are available for ear mite infestations in dogs. OBJECTIVE: The efficacy of sarolaner was evaluated against ear mite infestation caused by Otodectes cynotis in dogs and compared with topical moxidectin/imidacloprid in a single-masked, multi-centre field study. ANIMALS: Client-owned dogs with O. cynotis infestation were treated monthly with oral sarolaner (n = 163) or topical moxidectin/imidacloprid (n = 78). METHODS: The presence of mites in the ear canals and the clinical signs associated with otoacariasis (including head shaking, pruritus/ear scratching, trauma or alopecia of the pinnae, and erythema, ulceration and debris in the ear canals) was evaluated on days 0, 14 and 30, and, if applicable, on day 60...
February 1, 2018: Veterinary Dermatology
Amélie Nicolau, Karin Lemberger, Marion Mosca, Antoine Leclerc, Alexis Lécu, Didier Pin
BACKGROUND: Captive Andean bears (Tremarctos ornatus) develop a distinct alopecic syndrome of unknown aetiology. HYPOTHESIS/OBJECTIVES: To describe the histological features of healthy Andean bear skin, to define the clinical and histopathological features of Andean bears with signs of alopecia, and to propose an aetiopathogenesis. ANIMALS: Eighteen healthy Andean bears housed in 12 European zoos and 13 Andean bears with mild to severe alopecia housed in nine European zoos...
January 31, 2018: Veterinary Dermatology
Lerpen Duangkaew, Heather Hoffman
No abstract text is available yet for this article.
January 31, 2018: Veterinary Dermatology
Wei Yee Chan, Elizabeth E Hickey, Manouchehr Khazandi, Stephen W Page, Darren J Trott, Peter B Hill
BACKGROUND: Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Re-purposing of old drugs that are not used in human medicine is one approach that addresses the emergence of multidrug resistance in canine skin and ear infections, and can reduce the use of critically important human antibiotic classes. HYPOTHESIS/OBJECTIVES: To determine the antimicrobial activity of narasin, a polyether ionophore conventionally used as a rumen modifier and anticoccidial agent in production animals, against common clinical isolates of canine otitis externa (OE)...
January 24, 2018: Veterinary Dermatology
Melissa Eisenschenk
No abstract text is available yet for this article.
January 24, 2018: Veterinary Dermatology
Anette Loeffler, Daniel O Morris, Meghan F Davis, Luca Guardabassi, Scott Weese
No abstract text is available yet for this article.
January 24, 2018: Veterinary Dermatology
Ji-Hyung Park, Jung-Hun Kang, Jae-Eun Hyun, Cheol-Yong Hwang
BACKGROUND: Mupirocin is a topical antibacterial drug used for the treatment of staphylococcal infections, including meticillin-resistant Staphylococcus pseudintermedius (MRSP). The recent emergence of resistance to mupirocin is a major concern in many countries. OBJECTIVES: This study investigated the prevalence and genotype of mupirocin-resistant S. pseudintermedius isolated from pet dogs with pyoderma. SAMPLES: A total of 110 clinical isolates of S...
January 23, 2018: Veterinary Dermatology
Katrin Timm, Ralf S Mueller, Claudia S Nett-Mettler
BACKGROUND: Subcutaneous allergen immunotherapy (SCIT) is an established and efficacious therapy for canine atopic dermatitis (AD). In humans, intralymphatic immunotherapy (ILIT) was reported to be associated with fewer and less severe adverse effects than subcutaneous allergen immunotherapy and to be efficacious for several years after three intralymphatic injections. OBJECTIVE: To evaluate safety and effects of ILIT in a case series of dogs with (AD). ANIMALS: Fifty one privately owned dogs with AD...
January 12, 2018: Veterinary Dermatology
Matthew J H Carnett, Jon D Plant
BACKGROUND: Percutaneous testing (PT) is preferred to intradermal testing in humans for the in vivo identification of allergen hypersensitivity, but the methodology has not been well described for use in dogs with atopic dermatitis. HYPOTHESIS/OBJECTIVES: To identify the irritant threshold concentrations (ITC) of eight aeroallergens using a commercial prick test device in normal dogs. ANIMALS: Twenty healthy, privately owned dogs. METHODS: Percutaneous testing was performed using the GREER® Pick® System (Stallergenes Greer; Lenoir, NC, USA)...
January 8, 2018: Veterinary Dermatology
Alberto M Cordero, Simon Quek, Ralf S Mueller
BACKGROUND: Generalized demodicosis is a common disease in dogs and doramectin has been reported as a successful treatment. Different treatment protocols using doramectin have not been previously evaluated. OBJECTIVE: To evaluate whether oral administration of doramectin twice a week is more effective than administration by subcutaneous injection once a week. ANIMALS: Twenty nine privately owned dogs affected with generalized demodicosis. METHODS: Dogs randomly received one of two treatments...
December 29, 2017: Veterinary Dermatology
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