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Indian Journal of Hematology & Blood Transfusion

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https://www.readbyqxmd.com/read/27812273/packed-red-blood-cells-and-platelet-transfusion-support-in-patients-undergoing-bone-marrow-transplantation-analysis-of-82-cases
#1
Rahul Naithani, Mansi Sachdev, Reeta Rai, Manoj Singh
No abstract text is available yet for this article.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812272/autoimmune-haemolytic-anaemia-in-a-child-due-to-chickenpox
#2
Mukesh Kumar, Nirupama Kothari, B D Gupta
No abstract text is available yet for this article.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812271/peri-anal-paraneoplastic-pemphigus-heralding-the-relapse-of-follicular-lymphoma-and-its-successful-management-by-rituximab-a-short-correspondence
#3
Ankur Jain, Gaurav Prakash, Ram V Nampoothiri, Dipankar De, Amanjit Bal, Alka Khadwal, Deepesh Lad, Pankaj Malhotra, Subhash Varma
No abstract text is available yet for this article.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812270/the-mysterious-story-of-brown-blood-and-high-saturation-gap
#4
Hans Raj Pahadiya, Manoj Lakhotia, Ronak Gandhi, Gopal Raj Prajapati
No abstract text is available yet for this article.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812269/detection-of-hemoglobin-new-york-%C3%AE-113-g15-val%C3%A2-glu-gtg-gag-in-a-thai-woman-by-capillary-electrophoresis
#5
Sitthichai Panyasai, Sakorn Pornprasert
Hemoglobin (Hb) New York [β113 (G15) Val→Glu, GTG>GAG] is a very rare β-chain variant found in Thailand. This variant is often missed by routine laboratory testing because Hb New York and Hb A have the identical retention time on high performance liquid chromatography. We reported here for the first time that the detection of Hb New York in a Thai woman by using capillary electrophoresis (CE). A peak of Hb New York located ahead of Hb A at the electrophoretic zone 11 with a level of 42.8 %. The DNA sequencing revealed the GTG>GAG mutation at codon 113 for Hb New York on one allele of β-globin gene...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812268/strawberry-pink-blood
#6
Jayashree D Kulkarni, Puneeta Bhatia, Sanjay A Pai
Blood need not always be red. We report a case of a 3 month old boy whose blood was strawberry pink before centrifugation and white (profusely lipemic) after centrifugation. The differential diagnosis was familial hypercholesterolemia or familial combined hyperlipidemia.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812267/pulmonary-lymphoma-misdiagnosed-as-pneumonia
#7
Jungsil Lee, Hyunkyung Park, Yeon Wook Kim, Chul-Gyu Yoo
Pulmonary lymphoma is a very rare cause of lung tumors which occurs in less than one percent of primary malignant lung tumors. When seemingly pneumonia does not respond to treatment, the possibility of malignant lymphoma should always be considered. Here, we report two cases of pulmonary lymphoma misdiagnosed as pneumonia.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812266/knuckle-pigmentation-a-clue-to-systemic-illness
#8
Arjun Lakshman, Ram V Nampoothiri, Sreejesh Sreedharanunni, Pankaj Malhotra, Subhash Varma
No abstract text is available yet for this article.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812265/rhabdomyolysis-after-allogeneic-hematopoietic-stem-cell-transplantation
#9
Q Jiang, B H Zhang
No abstract text is available yet for this article.
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812264/revisiting-a-complex-rearrangement-involving-a-619-base-pairs-deletion-6-nucleotide-insertion-followed-by-a-a%C3%A2-%C3%A2-g-substitution-causing-%C3%AE-%C3%A2-thalassemia
#10
Samira DabbaghBagheri, Shirin Ghadami, Faeze Mollazadeh, Ameneh Saadat, Sirous Zeinali
One of the prevalent inherited blood disorders is thalassemia syndrome that characterized by reduction (β+) or absence (β0) of β globin chain synthesis. The β globin (HBB) gene map in the short arm of chromosome 11 and most of the mutations in this gene are single nucleotide substitutions, insertions or deletions of nucleotides. Nucleotide sequence analysis of a partially deleted β-globin gene from an Iranian carrier of β-thalassemia displayed a complex rearrangement involving a 619 base pairs (bp) deletion...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812263/clinical-significance-of-rare-maternal-anti-jk-a-antibody
#11
Kshitija Mittal, Tanvi Sood, Naveen Bansal, Ravneet Kaur Bedi, Paramjit Kaur, Gagandeep Kaur
We hereby report a rare case of HDFN because of antibody to Kidd (Jk) blood group system-anti Jk(a). An EDTA sample of a baby along with mother's sample was received in the Department for Direct Antiglobulin Test (DAT) alongwith blood requisition for double volume exchange transfusion. On blood grouping, baby's and mother's blood group was found to be B Rh D positive. DAT with polyspecific anti human globulin (AHG) was positive. Screening of mother's serum for irregular antibodies showed anti-Jk(a) antibody...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812262/membranoproliferative-glomerulonephritis-secondary-to-a-low-grade-lymphoproliferative-disorder-a-rare-cause-of-renal-dysfunction
#12
Tushar Sehgal, Nidhi Jain, Gaurav Prakash, Ritambhra Duseja, Neelam Varma
Chronic lymphocytic leukemia is a B-cell neoplasm with an indolent clinical course. Most patients are asymptomatic and are diagnosed incidentally on a routine blood count. The malignant cells of this low-grade neoplasm infiltrate various organs and tissues. However, the resultant end organ damage is a rare phenomenon. Here we describe a case of chronic lymphocytic leukemia that presented with an unusual cause of acute renal dysfunction. The patient had deranged renal parameters with a nephrotic range proteinuria...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812261/clinical-characteristics-and-prognostic-factors-in-hemophiliacs-with-intracranial-hemorrhage-a-single-center-retrospective-experience
#13
Jung Yoon Cho, Won Seok Lee, Young Shil Park, Seung Hwan Lee, Jun Seok Koh
Intracranial hemorrhage (ICH) is the most serious bleeding event that occurs in patients with hemophilia; its estimated mortality rate is approximately 20 %, accounting for the largest number of deaths from bleeding. We conducted this single-center, retrospective study to examine the characteristics of and prognostic factors in patients with hemophilia. A comprehensive review of 12 cases of intracranial hemorrhage (ICH) among 10 patients. All 12 cases of ICH in the 10 patients were treated with clotting factor concentrates...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812260/red-cell-distribution-width-has-a-predictable-value-for-differentiation-of-provoked-and-unprovoked-venous-thromboembolism
#14
Sehmus Ertop, Muammer Bilici, Huseyin Engin, Cagatay Buyukuysal, Muzeyyen Arslaner, Bilal Toka, Ishak Ozel Tekin
Venous thromboembolism (VTE) is generally classified as provoked or unprovoked. This dichotomy is important for following patients, mortality rate, prognosis and whether more efficient therapy is needed. In VTE patients, during initial diagnosis, it is not known exactly whether red cell distribution width (RDW) have a predictable value for this differentiation and pathogenesis. In this study, 298 patients with VTE and 197 control subjects were included. Patients with VTE were defined as provoked or unprovoked with respect to physical examination findings and laboratory values...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812259/genotyping-of-intron-inversions-and-point-mutations-in-exon-14-of-the-fviii-gene-in-iranian-azeri-turkish-families-with-hemophilia-a
#15
Mahmoud Shekari Khaniani, Abdollah Ebrahimi, Setareh Daraei, Sima Mansoori Derakhshan
Hemophilia A (HA) is an inherited X-linked bleeding disorder caused by a variety of mutations that are distributed throughout the large FVIII gene (F8). The most common mutations in studied populations with severe HA are introns 22 and 1 inversions, gross exon deletions and point mutations in exon 14. The aim of this study was to define the frequency of these common mutations in Iranian population of Azeri Turkish in North West of Iran. Fifty patients with severe HA and forty-three female potential carriers were genotyped by inverse shifting polymerase chain reaction (IS-PCR), long-range PCR, multiplex PCR, and sequencing methods for the detection of Intron 22 and 1 inversions, gross exon deletions, and exon 14 point mutations, respectively...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812258/presentation-and-outcome-of-castleman-s-disease-in-immunocompetent-hosts
#16
Gaurav Prakash, Amanjeet Bal, Pankaj Malhotra, Vaishali Aggarwal, Alka Khadwal, Vikas Suri, Sanjay Jain, Savita Kumari, Radhika Srinivasan, Ashim Das, Neelam Varma, Subhash Varma
Castleman's disease (CD) is a heterogeneous lymphoproliferative disorder of unknown aetiology. Mostly, this disorder is seen in immunocompromised hosts. It is known to be associated with systemic disorders like HIV, HHV-8, lymphoma, and Kaposi sarcoma. As of today, the clinical behaviour and outcome of CD in immunocompetent host remains suboptimally studied. We analyzed consecutively treated cases of CD presented to our centre in last 12 years. Case record files were studied for patient's characteristics, clinical presentation, baseline laboratory and pathologic parameters, therapy and outcome...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812257/differential-expression-of-t-bet-and-gata3-in-egyptian-children-with-idiopathic-thrombocytopenic-purpura
#17
Amira Ahmed Hammam, Dina Ahmed Ezzat, Marwa Hamed Abd Elwahab
GATA3 and T-box (T-bet) expressed in T-cells are transcriptional factors that play a critical role in development of Th2 and Th1 immunity respectively. GATA3 is expressed during Th2 differentiation and T-bet is expressed exclusively in Th1 cells. Thus, a balance between GATA3 and T-bet is believed to control Th2/Th1 polarization. Therefore, the high expression of T-bet and low expression of GATA3 indicate the existence of Th1 polarization in children with acute immune thrombocytopenic purpura (ITP). This might be related to the regulation of T-bet and GATA3...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812256/detection-of-%C3%AE-thalassemia-by-using-multiplex-ligation-dependent-probe-amplification-as-an-additional-method-for-rare-mutations-in-southern-turkey
#18
Ozge Ozalp Yuregir, Akif Ayaz, Sinem Yalcintepe, Sezin Canbek, Didar Yanardag Acik, Basak Taburoglu Yilmaz, Tugce B Balci
α-thalassemia is the most common single gene disorder in the Cukurova Region in Turkey. It is therefore routinely screened, including premaritally, in our region. The heterogeneous molecular basis of the disease makes α-thalassemia mutation detection difficult and complex. Besides well established methods, multiplex ligation dependent probe amplification (MLPA) is known as an effective, simple and specific method for the detection and characterization of deletions and duplications. We employed MLPA testing to 30 patients with hematological parameters suggestive of α-thalassemia carrier status but was negative for α-thalassemia with conventional reverse dot blot hybridization (RDB)...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812255/fetal-rhd-genotyping-from-circulating-cell-free-fetal-dna-in-plasma-of-rh-negative-pregnant-women-in-iran
#19
Mohammad Hossein Ahmadi, Sedigheh Hantuoshzadeh, Mohammad Ali Okhovat, Nahid Nasiri, Azita Azarkeivan, Naser Amirizadeh
The prenatal determination of the fetal Rh genotype could lead to a substantial reduction in the use of anti-D immunoglobulin and prevention of unnecessary exposure of pregnant women carrying RhD negative fetus. The aim of this study was fetal RHD genotyping through the analysis of cffDNA in plasma samples of RhD negative pregnant women by real-time PCR technique. In this experiment, 30 plasma samples were collected from RhD negative pregnant women. DNA were extracted and real-time PCR reactions were done by specific primers for RHD, SRY and beta-globin (GLO) genes...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27812254/evaluation-of-magnetized-erythrocyte-group-antigens-to-detect-abo-antibodies
#20
O Nathalang, K Intharanut, P Sriwanitchrak, M Setthakarn, S Duan, H Wang, S Ding, Y Li
Screening for IgM titers of anti-A and anti-B is recommended when providing ABO incompatible platelet transfusion. The life-time of reagent cells depends upon the preservative diluents. We aimed to evaluate the IgM titers of anti-A and anti-B testing with magnetized-erythrocyte group antigens (MEGA) and fresh RBCs and study the relationship of ABO antibody titers between both techniques. Altogether, 100 serum samples from group O donors at the National Blood Centre, Thai Red Cross Society, Bangkok, Thailand were included...
December 2016: Indian Journal of Hematology & Blood Transfusion
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