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Indian Journal of Hematology & Blood Transfusion

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https://www.readbyqxmd.com/read/29075088/t-lineage-acute-lymphoblastic-leukemia-with-granular-blasts
#1
Pulkit Rastogi, Shano Naseem, Deepak Bansal, Neelam Varma
No abstract text is available yet for this article.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075087/bcr-abl-and-jak2v617f-mutation-co-existence-rare-or-just-unexplored
#2
H S Darling, Rajiv Kumar, Rajan Kapoor, Jasjit Singh, Tarun Verma
Current hematology practice distinguishes chronic myeloid leukemia (CML) and other major chronic myeloproliferative neoplasms as different entities classically characterized by positivity of BCR-ABL fusion gene and JAK2V617F mutations. These are different in clinical presentation, molecular genetics, therapy and response to present treatments. Nevertheless, there have been occasional case reports of detection of both mutations in the same patient. Although some of these had been incidentally detected, most have manifested clinically while being treated for one disease...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075086/cd138-negative-plasma-cells-in-relapsed-cns-multiple-myeloma
#3
Neha Singh, Jatin S Gandhi, Narendra Agrawal, Ajit Panaych, Narender Tejwani, Anurag Mehta
No abstract text is available yet for this article.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075085/discrepancy-in-blood-grouping-subgroups-of-b-challenges-and-dilemma
#4
Rahul Chaurasia, Diptiranjan Rout, Kanchan Dogra, Poonam Coshic, Kabita Chatterjee
Though not very frequent, blood group discrepancies are of common occurrence which must be promptly resolved for safe transfusion practices. Blood group discrepancy is defined as the non-corroboration between cell grouping and serum grouping. Variable erythrocyte antigenic expressions (qualitative and/or quantitative difference) owing to allelic heterogeneity, give rise to subgroups. Problems during blood grouping due to weakened expression of antigens are a rare cause for ABO discrepancies. Of note, subgroups of 'B' with decreased expression of the B antigen are of very rare occurrence in the general population...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075084/dilemma-abo-incompatible-liver-transplant-in-a-patient-with-an-anaphylactic-reaction-to-fresh-frozen-plasma
#5
Shruti Gupta, Meenu Bajpai, Viniyendra Pamecha
No abstract text is available yet for this article.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075083/increasing-non-albicans-candida-in-hematological-patients-with-fluconazole-prophylaxis-a-case-series
#6
Areena Hoda Siddiqui, Sunil Dabadghao, Ashish Tewari, Vipul Kumar Srivastava
No abstract text is available yet for this article.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075082/response-to-alpha-interferon-treatment-of-the-congenital-dyserythropoietic-anemia-type-i-in-two-sicilian-beta-thalassemia-carriers
#7
V Agrigento, R Barone, S Sclafani, R Di Maggio, M Sacco, A Maggio, E D'Alcamo
Congenital dyserythropoietic anemia type I (CDAI) is an autosomal recessive inherited haematological disorder associated with moderate-to-severe anemia characterized by ineffective erythropoiesis with distinct morphological abnormalities in erythroid precursors. We present two case of congenital dyserythropoietic anemia type I in two Sicilian patients heterozygous for β(0) 39 globin gene cod 39 C > T with marked bone marrow abnormalities, responding to treatment with alpha interferon. The diagnosis was established using routine haematological and biochemical test, light and electron microscopy; molecular analysis of the CDAN1 gene associated to the CDAI disease was performed...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075081/co-inheritance-of-hb-j-kaohsiung-%C3%AE-59-e3-aag-acg-lys%C3%A2-thr-and-hbe-%C3%AE-26-b8-gag-aag-glu%C3%A2-lys-in-a-thai-woman
#8
Sitthichai Panyasai, Sakorn Pornprasert
No abstract text is available yet for this article.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075080/unusual-hypergranular-myelomatous-plasma-cells
#9
Giovanni D'Arena, Pellegrino Musto
No abstract text is available yet for this article.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075079/diagnostic-dilemma-in-the-morphological-detection-of-flower-cells-in-lymphomas
#10
Neha Singh, Jatin Gandhi, Narendra Agrawal, Ajit Panaych, Narender Tejwani, Anurag Mehta
"Flower cells" are described typically in HTLV-1 induced adult T cell leukemia. Very few case reports have been published documenting flower cells in B cell lymphomas. We herein present a case of Burkitt lymphoma proven on the basis of immunophenotyping and FISH studies, with "flower cells" morphology.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075078/a-novel-double-heterozygous-hb-d-punjab-hb-j-meerut-hemoglobinopathy
#11
Dinesh Chandra, Seema Tyagi, Roopam Deka, Richa Chauhan, Tulika Seth, Renu Saxena, H P Pati
A comprehensive laboratory diagnosis of hemoglobinopathies forms an integral part in workup of disorders of globin chain synthesis. Clinical findings, complete blood counts, peripheral smear examination along with hemoglobin (Hb) electrophoresis and/or cation exchange high performance liquid chromatography findings and parental study helps to clinch a final diagnosis. Compound heterozygous hemoglobinopathy presents with variable clinical findings and some of them are picked up on screening tests done as part of routine antenatal workup...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075077/bone-histo-morphology-in-chronic-kidney-disease-mineral-bone-disorder
#12
Khuraijam Bembem, Tejinder Singh, Narinder Pal Singh, Alpana Saxena, Shyama Lata Jain
Chronic Kidney Disease-Mineral Bone Disorder(CKD-MBD) is a systemic disorder of the mineral and bone metabolism seen in patients with Chronic Kidney Disease(CKD). It is manifested by either one or a combination of the following: (a) Abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism. (b) Abnormalities in bone turnover, mineralization, volume, linear growth, or strength. (c) Vascular or other soft- tissue calcification. Renal osteodystrophy measures the skeletal component of CKD-MBD. To study the histomorphology of bone marrow biopsy in patients with CKD-MBD and correlate the histological features of bone biopsy with the clinicobiochemical parameters...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075076/study-of-hemolysis-during-storage-of-blood-in-the-blood-bank-of-a-tertiary-health-care-centre
#13
Sayeedul Hasan Arif, Neha Yadav, Suhailur Rehman, Ghazala Mehdi
The aim of RBC storage system in a blood bank is to counteract damage to the metabolic machinery and the membrane, to improve post-transfusion viability. In recent years, the need for strict control over the quality of blood has been emphasised. Such quality indicator includes extend of hemolysis and morphological changes of RBC during storage. This study was design to see extend of hemolysis and level of plasma lactate dehydrogenase (LDH) and plasma potassium, during processing and storage at different intervals under blood bank condition...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075075/a-study-on-the-effect-of-pre-donation-salt-loading-on-vasovagal-reactions-in-young-college-going-whole-blood-donors
#14
Suchet Sachdev, Lakhvinder Singh, Ratti Ram Sharma, Neelam Marwaha
INTRODUCTION: The pathophysiology of vasovagal reactions (VVRs) involves both psychological and physiological components. Strategies which could allay physiological changes include interventions like pre-donation water intake and applied muscle tension have been published, however salt loading has not been tested. MATERIALS AND METHODS: Cross sectional study enrolling 1000 young college going whole blood donors with intervention 250 ml of salted loaded water or plain water as placebo...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075074/percentage-of-memory-b-lymphocytes-and-regulatory-t-lymphocytes-in-peripheral-blood-are-low-but-not-predictive-of-therapy-outcomes-in-newly-diagnosed-adult-patients-with-primary-immune-thrombocytopenia
#15
Mustafa Yilmaz, Semiha Ayhan
Although changes in the number and function of regulatory T lymphocytes have been reported in primary immune thrombocytopenia (ITP), no study has investigated whether quantification of these cell types in peripheral blood could be used as early predictive marker of treatment outcome. And, it is not clear whether any change occurs in peripheral blood memory B lymphocyte levels in ITP. Hence, the aim of this study was to investigate the percentage of regulatory T lymphocytes and memory B lymphocytes in peripheral blood of ITP patients compared to controls, and also examine whether these levels have any significant predictive value for therapy outcome...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075073/moderate-to-severe-thrombocytopenia-during-pregnancy-a-single-institutional-experience
#16
Bum Jun Kim, Hyeong Su Kim, Jung Han Kim, Keun Young Lee
Most of thrombocytopenic pregnant women present mild decrease of platelet counts and have favorable outcome. However, small portion of these cases can show moderate to severe thrombocytopenia and may increase the risk of bleeding during delivery. We investigated the prevalence, causes, and outcomes of pregnancies complicated by moderate to severe thrombocytopenia. We reviewed medical records of pregnant women who were diagnosed with moderate to severe thrombocytopenia (<100 × 10(9)/L) during their pregnancies...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075072/evaluation-of-coagulation-profile-in-children-with-type-1-diabetes-mellitus-using-rotational-thromboelastometry
#17
Cigdem Binay, Ayse Bozkurt Turhan, Enver Simsek, Ozcan Bor, Olga Meltem Akay
The prothrombotic state in type 1 diabetes mellitus (T1DM) has been reported as a plausible cause of vascular complications. Rotational thromboelastometry (ROTEM) assay enables the global assessment of coagulation status. This study aimed to assess hypercoagulability in children with T1DM using ROTEM. A total of 43 T1DM children (20 females and 23 males) aged 2-18 years and age- and sex-matched 30 healthy control subjects were enrolled in the study group. ROTEM assays [intrinsic TEM (INTEM) and extrinsic TEM (EXTEM)] were used to measure and analyze coagulation time (CT), clot formation time, maximum clot firmness (MCF)...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075071/low-dose-rituximab-in-chronic-itp-still-an-option-in-resource-limited-settings
#18
Rajan Kapoor, Rajiv Kumar, M Mahapatra, H P Pati, Suman Kumar Pramanik
The etiology of ITP remains unknown but its pathogenesis consists of loss of tolerance to platelet antigens. There is a complex dysregulation of the immune system involving both the B cells and the T cells. Splenectomy is the standard second line option in steroid refractory chronic ITP patients. However, costs of surgery and reluctance for surgery in severely thrombocytopenic patients on part of surgeons are major obstacles in resource limited settings. Rituximab has been used in both the standard doses of 375 mg/m(2) and low doses of 100 mg/m(2) with similar results...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075070/validity-of-estimation-of-haemoglobin-content-in-dried-blood-spot-samples
#19
Aakriti Gupta, Umesh Kapil, Lakshmy Ramakrishnan, Preetika Khenduja, Chandra Prakash Yadav, Nighat Yaseen Sofi, Ritika Khandelwal
The ability to use indirect cyanmethemoglobin method using 20 µl of dried blood spots (DBSs) on filter paper for the analysis of haemoglobin (Hb) levels could be an important diagnostic tool for areas that have limited access to laboratory facilities. We assessed the validity of a method for Hb estimation in which a single drop of whole blood was directly taken on the filter paper. We collected 124 DBSs containing 20 µl of blood (filter paper A) and single drop of whole blood (filter paper B) from subjects living in Nainital, Uttrakhand...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29075069/buccal-mucosa-exfoliative-cell-prussian-blue-stain-co-relates-with-iron-overload-in-%C3%AE-thalassemia-major-patients
#20
Pooja K Gajaria, Ujwala M Maheshwari, D B Borkar, Reeta Dhar, Varsha Pancholi
Thalassemics require regular blood transfusion therapy leading to iron overload in the body tissues, which is a major cause of morbidity and mortality in these patients. We hereby attempted to measure this iron overload by means of exfoliative cytology, a non-invasive and inexpensive technique. The aims and objectives of our study were: 1. To detect iron overload by oral exfoliative cytology using Perl's Prussian blue stain in β-thalassemia major patients. 2. To correlate staining positivity with serum ferritin levels...
December 2017: Indian Journal of Hematology & Blood Transfusion
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