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Cell Research

Li-Wa Shao, Rong Niu, Ying Liu
Neurons have a central role in the systemic coordination of mitochondrial unfolded protein response (UPR(mt)) and the cell non-autonomous modulation of longevity. However, the mechanism by which the nervous system senses mitochondrial stress and communicates to the distal tissues to induce UPR(mt) remains unclear. Here we employ the tissue-specific CRISPR-Cas9 approach to disrupt mitochondrial function only in the nervous system of Caenorhabditis elegans, and reveal a cell non-autonomous induction of UPR(mt) in peripheral cells...
October 21, 2016: Cell Research
Deepak Adhikari, Kiran Busayavalasa, Jingjing Zhang, Mengwen Hu, Sanjiv Risal, Mustafa Bilal Bayazit, Meenakshi Singh, M Kasim Diril, Philipp Kaldis, Kui Liu
A unique feature of female germ cell development in mammals is their remarkably long arrest at the prophase of meiosis I, which lasts up to 50 years in humans. Both dormant and growing oocytes are arrested at prophase I and completely lack the ability to resume meiosis. Here, we show that the prolonged meiotic arrest of female germ cells is largely achieved via the inhibitory phosphorylation of Cdk1 (cyclin-dependent kinase 1). In two mouse models where we have introduced mutant Cdk1(T14AY15F) which cannot be inhibited by phosphorylation (Cdk1AF) in small meiotically incompetent oocytes, the prophase I arrest is interrupted, leading to a premature loss of female germ cells...
October 21, 2016: Cell Research
Thomas Voets
Two recent studies reveal a crucial role for the cation channel TRPM2 in sensing warm temperatures, both in the thermoregulatory center of the brain and in the somatosensory system.
October 21, 2016: Cell Research
Delphine Mieulet, Sylvie Jolivet, Maud Rivard, Laurence Cromer, Aurore Vernet, Pauline Mayonove, Lucie Pereira, Gaëtan Droc, Brigitte Courtois, Emmanuel Guiderdoni, Raphael Mercier
Introduction of clonal reproduction through seeds (apomixis) in crops has the potential to revolutionize agriculture by allowing self-propagation of any elite variety, in particular F1 hybrids. In the sexual model plant Arabidopsis thaliana synthetic clonal reproduction through seeds can be artificially implemented by (i) combining three mutations to turn meiosis into mitosis (MiMe) and (ii) crossing the obtained clonal gametes with a line expressing modified CENH3 and whose genome is eliminated in the zygote...
October 21, 2016: Cell Research
Xia Chen, Kailin Yang, Chen Wu, Cheng Chen, Can Hu, Olga Buzovetsky, Zefang Wang, Xiaoyun Ji, Yong Xiong, Haitao Yang
No abstract text is available yet for this article.
October 18, 2016: Cell Research
Huiwu Tang, Xingmei Zheng, Chuliang Li, Xianrong Xie, Yuanling Chen, Letian Chen, Xiucai Zhao, Huiqi Zheng, Jiajian Zhou, Shan Ye, Jingxin Guo, Yao-Guang Liu
New gene origination is a major source of genomic innovations that confer phenotypic changes and biological diversity. Generation of new mitochondrial genes in plants may cause cytoplasmic male sterility (CMS), which can promote outcrossing and increase fitness. However, how mitochondrial genes originate and evolve in structure and function remains unclear. The rice Wild Abortive type of CMS is conferred by the mitochondrial gene WA352c (previously named WA352) and has been widely exploited in hybrid rice breeding...
October 11, 2016: Cell Research
Berthe Katrine Fiil, Mads Gyrd-Hansen
Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.
September 30, 2016: Cell Research
Zhi-Jian Song, Zachary J Reitman, Zeng-Yi Ma, Jian-Hua Chen, Qi-Lin Zhang, Xue-Fei Shou, Chuan-Xin Huang, Yong-Fei Wang, Shi-Qi Li, Ying Mao, Liang-Fu Zhou, Bao-Feng Lian, Hai Yan, Yong-Yong Shi, Yao Zhao
No abstract text is available yet for this article.
September 27, 2016: Cell Research
Jochem H Bernink, Hergen Spits, Wouter J de Jonge
A recent paper published in Nature demonstrates a multifaceted relation between enteric glial cells (EGC), intestinal epithelia, and ILC3, via the EGC release of neurotrophic factors, a structurally related group of ligands within the TGF-β superfamily of signaling molecules and IL-22 produced by ILC3.
September 16, 2016: Cell Research
Yan Li, Ming-Shan Wang, Newton O Otecko, Wen Wang, Peng Shi, Dong-Dong Wu, Ya-Ping Zhang
No abstract text is available yet for this article.
September 9, 2016: Cell Research
Rosalind F Roberts, Edward A Fon
In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.
September 2, 2016: Cell Research
Kefang Liu, Shuguang Tan, Yan Chai, Danqing Chen, Hao Song, Catherine Wei-Hong Zhang, Yi Shi, Jun Liu, Wenjie Tan, Jianxin Lyu, Shan Gao, Jinghua Yan, Jianxun Qi, George F Gao
No abstract text is available yet for this article.
August 30, 2016: Cell Research
Fei Li, Zhaoyuan Fang, Jian Zhang, Chen Li, Hongyan Liu, Jufeng Xia, Hongwen Zhu, Chenchen Guo, Zhen Qin, Fuming Li, Xiangkun Han, Yuetong Wang, Yan Feng, Ye Wang, Wenjing Zhang, Zuoyun Wang, Yujuan Jin, Yihua Sun, Wenyi Wei, Rong Zeng, Haiquan Chen, Hongbin Ji
Lung squamous cell carcinoma (SCC) is one of the major subtypes of lung cancer. Our current knowledge of oncogenic drivers in this specific subtype of lung cancer is largely limited compared with lung adenocarcinoma (ADC). Through exon array analyses, molecular analyses and functional studies, we here identify the TRA2B-DNAH5 fusion as a novel oncogenic driver in lung SCC. We found that this gene fusion occurs exclusively in lung SCC (3.1%, 5/163), but not in lung ADC (0/119). Through mechanistic studies, we further revealed that this TRA2B-DNAH5 fusion promotes lung SCC malignant progression through regulating a SIRT6-ERK1/2-MMP1 signaling axis...
October 2016: Cell Research
Sylvia Tielens, Sandra Huysseune, Juliette D Godin, Alain Chariot, Brigitte Malgrange, Laurent Nguyen
The migration of cortical interneurons is a fundamental process for the establishment of cortical connectivity and its impairment underlies several neurological disorders. During development, these neurons are born in the ganglionic eminences and they migrate tangentially to populate the cortical layers. This process relies on various morphological changes that are driven by dynamic cytoskeleton remodelings. By coupling time lapse imaging with molecular analyses, we show that the Elongator complex controls cortical interneuron migration in mouse embryos by regulating nucleokinesis and branching dynamics...
October 2016: Cell Research
Lorenzo Galluzzi, Guido Kroemer
At odds with their normal counterparts, hepatocellular carcinoma cells efficiently utilize ketone bodies to proliferate despite serum deprivation. These findings, which have been recently published in Cell Research, identify a novel metabolic circuitry through which tumors successfully cope with adverse microenvironmental conditions.
October 2016: Cell Research
De Huang, Tingting Li, Lin Wang, Long Zhang, Ronghui Yan, Kui Li, Songge Xing, Gongwei Wu, Lan Hu, Weidong Jia, Sheng-Cai Lin, Chi V Dang, Libing Song, Ping Gao, Huafeng Zhang
Cancer cells are known for their capacity to rewire metabolic pathways to support survival and proliferation under various stress conditions. Ketone bodies, though produced in the liver, are not consumed in normal adult liver cells. We find here that ketone catabolism or ketolysis is re-activated in hepatocellular carcinoma (HCC) cells under nutrition deprivation conditions. Mechanistically, 3-oxoacid CoA-transferase 1 (OXCT1), a rate-limiting ketolytic enzyme whose expression is suppressed in normal adult liver tissues, is re-induced by serum starvation-triggered mTORC2-AKT-SP1 signaling in HCC cells...
October 2016: Cell Research
Ping Lu, Fu-Chuang Zhang, Shu-Wen Qian, Xi Li, Zhao-Meng Cui, Yong-Jun Dang, Qi-Qun Tang
No abstract text is available yet for this article.
October 2016: Cell Research
Filip Van Petegem
Ryanodine Receptors are large ion channels responsible for the release of Ca from the Endoplasmic and Sarcoplasmic Reticulum, a prerequisite for muscle contraction. Recent cryo-electron microscopy data have allowed a direct visualization of allosteric motions within these membrane protein giants.
October 2016: Cell Research
Chang Xie, Ya-Ping Zhang, Lu Song, Jie Luo, Wei Qi, Jialu Hu, Danbo Lu, Zhen Yang, Jian Zhang, Jian Xiao, Bin Zhou, Jiu-Lin Du, Naihe Jing, Yong Liu, Yan Wang, Bo-Liang Li, Bao-Liang Song, Yan Yan
PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ventricular tachyarrhythmia and experience progressive heart failure that is refractory to medical treatment and requires cardiac transplantation. In this study, we identify a H530R mutation in PRKAG2 from patients with familial Wolff-Parkinson-White syndrome. By generating H530R PRKAG2 transgenic and knock-in mice, we show that both models recapitulate human symptoms including cardiac hypertrophy and glycogen storage, confirming that the H530R mutation is causally related to PRKAG2 cardiac syndrome...
October 2016: Cell Research
Ting Zhang, Yihong Ye
Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membrane-bound ubiquitin ligase complexes. Baldridge and Rapoport now reconstitute a key step of retrotranslocation, demonstrating a protein conduit gated by ubiquitination.
October 2016: Cell Research
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