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Cell Research

Feng Wang, Dong-Bing Liu, Qi Zhao, Gang Chen, Xin-Ming Liu, Ying-Nan Wang, Hong Su, Yan-Ru Qin, Yi-Fu He, Qing-Feng Zou, Yan-Hui Liu, You-En Lin, Ze-Xian Liu, Jin-Xin Bei, Rui-Hua Xu
No abstract text is available yet for this article.
May 4, 2018: Cell Research
Qinglin Tang, Wenjun Guo, Li Zheng, Jing-Xiang Wu, Meng Liu, Xindi Zhou, Xiaolin Zhang, Lei Chen
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the family of canonical transient receptor potential (TRPC) channels. They are activated by diacylglycerol, a lipid second messenger. TRPC6 and TRPC3 are involved in many physiological processes and implicated in human genetic diseases. Here we present the structure of human TRPC6 homotetramer in complex with a newly identified high-affinity inhibitor BTDM solved by single-particle cryo-electron microscopy to 3.8 Å resolution...
April 26, 2018: Cell Research
Xiaolan Deng, Rui Su, Hengyou Weng, Huilin Huang, Zejuan Li, Jianjun Chen
N6 -methyladenosine (m6 A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell self-renewal and differentiation, heat shock or DNA damage response, and maternal-to-zygotic transition. The m6 A modification is deposited by the m6 A methyltransferase complex (MTC; i.e., writer) composed of METTL3, METTL14 and WTAP, and probably also VIRMA and RBM15, and can be removed by m6 A demethylases (i...
April 23, 2018: Cell Research
(no author information available yet)
No abstract text is available yet for this article.
April 20, 2018: Cell Research
Matthew C Hill, James F Martin
No abstract text is available yet for this article.
April 19, 2018: Cell Research
Chenwen Huang, Wanzhi Tu, Yanbin Fu, Jinxi Wang, Xin Xie
No abstract text is available yet for this article.
April 18, 2018: Cell Research
Shuangyan Tan, Qiheng Gou, Wenchen Pu, Chenglin Guo, Yun Yang, Ke Wu, Yaxin Liu, Lunxu Liu, Yu-Quan Wei, Yong Peng
No abstract text is available yet for this article.
April 8, 2018: Cell Research
Jonathan Pol, Guido Kroemer
No abstract text is available yet for this article.
March 28, 2018: Cell Research
Biao Qiu, Bingqing Xia, Qingtong Zhou, Yan Lu, Miaomiao He, Kazuya Hasegawa, Zhiqiang Ma, Fengyu Zhang, Lichuan Gu, Qionglei Mao, Feng Wang, Suwen Zhao, Zhaobing Gao, Jun Liao
Acetate is an important metabolite in metabolism and cell signaling. Succinate-Acetate Permease (SatP) superfamily proteins are known to be responsible for acetate transport across membranes, but the nature of this transport remains unknown. Here, we show that the SatP homolog from Citrobacter koseri (SatP_Ck) is an anion channel that can unidirectionally translocate acetate at rates of the order of ~107  ions/s. Crystal structures of SatP_Ck in complex with multiple acetates at 1.8 Å reveal that the acetate pathway consists of four acetate-binding sites aligned in a single file that are interrupted by three hydrophobic constrictions...
March 27, 2018: Cell Research
Fang Yu, Guang Shi, Shimeng Cheng, Jiwei Chen, Shwu-Yuan Wu, Zhiqiang Wang, Nansong Xia, Yunhao Zhai, Zhenxing Wang, Yu Peng, Dong Wang, James X Du, Lujian Liao, Sheng-Zhong Duan, Tieliu Shi, Jinke Cheng, Cheng-Ming Chiang, Jiwen Li, Jiemin Wong
Regulation of transcription is fundamental to the control of cellular gene expression and function. Although recent studies have revealed a role for the oncoprotein MYC in amplifying global transcription, little is known as to how the global transcription is suppressed. Here we report that SUMO and MYC mediate opposite effects upon global transcription by controlling the level of CDK9 sumoylation. On one hand, SUMO suppresses global transcription via sumoylation of CDK9, the catalytic subunit of P-TEFb kinase essential for productive transcriptional elongation...
March 27, 2018: Cell Research
Lina Herhaus, Ivan Dikic
No abstract text is available yet for this article.
March 23, 2018: Cell Research
Shan Wang, Zhiqiang Peng, Siying Wang, Lihua Yang, Yuhan Chen, Xue Kong, Shanshan Song, Pei Pei, Chunyan Tian, Hui Yan, Peipei Ding, Weiguo Hu, Cui Hua Liu, Xin Zhang, Fuchu He, Lingqiang Zhang
We apologize for an error that we just found in the paper published online on 21 February 2018. The 1st row/1st column of Figure 8G (PITA Normal) was inadvertently duplicated from 2nd row/1st column of Figure 8I (PISA Adjacent colonic mucosa). The 2nd row/1st column of Figure 8G (PISA Normal) was inadvertently duplicated from 2nd row/2nd column of Figure 8G (PISA Distal colonic mucosa). A corrected version of Figure 8G is provided below. No conclusion was affected by this error, but we apologize for not detecting it before publication and any inconvenience caused...
March 23, 2018: Cell Research
Mrinal M Patnaik, Omar Abdel-Wahab
No abstract text is available yet for this article.
March 23, 2018: Cell Research
Xizi Chen, Mengjie Liu, Yuan Tian, Jiabei Li, Yilun Qi, Dan Zhao, Zihan Wu, Min Huang, Catherine C L Wong, Hong-Wei Wang, Jiawei Wang, Huirong Yang, Yanhui Xu
Mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) plays an essential role in regulating cell proliferation through phosphorylating AGC protein kinase family members, including AKT, PKC and SGK1. The functional core complex consists of mTOR, mLST8, and two mTORC2-specific components, Rictor and mSin1. Here we investigated the intermolecular interactions within mTORC2 complex and determined its cryo-electron microscopy structure at 4.9 Å resolution. The structure reveals a hollow rhombohedral fold with a 2-fold symmetry...
March 22, 2018: Cell Research
Monika L Burness, Max S Wicha
No abstract text is available yet for this article.
March 21, 2018: Cell Research
Jérôme Barbier, Xin Chen, Gabriel Sanchez, Muyan Cai, Marion Helsmoortel, Takuma Higuchi, Pierre Giraud, Xavier Contreras, Gangjun Yuan, Zihao Feng, Rima Nait-Saidi, Olivier Deas, Lisa Bluy, Jean-Gabriel Judde, Sylvie Rouquier, William Ritchie, Shuji Sakamoto, Dan Xie, Rosemary Kiernan
Reduced expression of DICER, a key enzyme in the miRNA pathway, is frequently associated with aggressive, invasive disease, and poor survival in various malignancies. Regulation of DICER expression is, however, poorly understood. Here, we show that NF90/NF110 facilitates DICER expression by controlling the processing of a miRNA, miR-3173, which is embedded in DICER pre-mRNA. As miR-3173 in turn targets NF90, a feedback amplification loop controlling DICER expression is established. In a nude mouse model, NF90 overexpression reduced proliferation of ovarian cancer cells and significantly reduced tumor size and metastasis, whereas overexpression of miR-3173 dramatically increased metastasis in an NF90- and DICER-dependent manner...
March 21, 2018: Cell Research
Xiangxiu Liang, Miaomiao Ma, Zhaoyang Zhou, Jinlong Wang, Xinru Yang, Shaofei Rao, Guozhi Bi, Lin Li, Xiaojuan Zhang, Jijie Chai, She Chen, Jian-Min Zhou
Arabidopsis heterotrimeric G proteins regulate diverse processes by coupling to single-transmembrane receptors. One such receptor is the FLS2 receptor kinase, which perceives bacterial flagellin epitope flg22 to activate immunity through a class of cytoplasmic kinases called BIK1/PBLs. Unlike animal and fungal heterotrimeric G proteins that are activated by a ligand-induced guanine nucleotide exchange activity of seven-transmembrane G protein-coupled receptors (GPCRs), plant heterotrimeric G proteins are self-activating...
March 15, 2018: Cell Research
Yannan Zhao, Lilan Luo, Jiesi Xu, Peiyong Xin, Hongyan Guo, Jian Wu, Lin Bai, Guodong Wang, Jinfang Chu, Jianru Zuo, Hong Yu, Xun Huang, Jiayang Li
Programmed cell death (PCD) is a fundamental biological process. Deficiency in MOSAIC DEATH 1 (MOD1), a plastid-localized enoyl-ACP reductase, leads to the accumulation of reactive oxygen species (ROS) and PCD, which can be suppressed by mitochondrial complex I mutations, indicating a signal from chloroplasts to mitochondria. However, this signal remains to be elucidated. In this study, through cloning and analyzing a series of mod1 suppressors, we reveal a comprehensive organelle communication pathway that regulates the generation of mitochondrial ROS and triggers PCD...
March 14, 2018: Cell Research
Shi-Yuan Li, Qiu-Xiang Cheng, Jia-Kun Liu, Xiao-Qun Nie, Guo-Ping Zhao, Jin Wang
No abstract text is available yet for this article.
March 12, 2018: Cell Research
Yuan-Liang Zhang, Jie-Wen Sun, Yin-Yin Xie, Yan Zhou, Ping Liu, Jia-Chun Song, Chun-Hui Xu, Lan Wang, Dan Liu, Ai-Ning Xu, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, Qiu-Hua Huang
The histone H3 lysine 36 methyltransferase SETD2 is frequently mutated in various cancers, including leukemia. However, there has not been any functional model to show the contribution of SETD2 in hematopoiesis or the causal role of SETD2 mutation in tumorigenesis. In this study, using a conditional Setd2 knockout mouse model, we show that Setd2 deficiency skews hematopoietic differentiation and reduces the number of multipotent progenitors; although the number of phenotypic hematopoietic stem cells (HSCs) in Setd2-deleted mice is unchanged, functional assays, including serial BM transplantation, reveal that the self-renewal and competitiveness of HSCs are impaired...
March 12, 2018: Cell Research
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