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Cell Research

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https://www.readbyqxmd.com/read/27922618/macroautophagy-without-lc3-conjugation
#1
Maurizio Renna, David C Rubinsztein
A recent study makes the surprising observation that autophagosomes can still form in the absence of the core conjugation machinery. Furthermore, while such autophagosomes can fuse with lysosomes, their degradation is delayed, and this is associated with delayed destruction of the inner autophagosomal double membrane, highlighting a new role for proteins thought to act exclusively in the formation of autophagosomes in late stages of the autophagic itinerary within autolysosomes.
December 6, 2016: Cell Research
https://www.readbyqxmd.com/read/27922617/transfer-of-convalescent-serum-to-pregnant-mice-prevents-zika-virus-infection-and-microcephaly-in-offspring
#2
Shuo Wang, Shuai Hong, Yong-Qiang Deng, Qing Ye, Ling-Zhai Zhao, Fu-Chun Zhang, Cheng-Feng Qin, Zhiheng Xu
No abstract text is available yet for this article.
December 6, 2016: Cell Research
https://www.readbyqxmd.com/read/27910851/crispr-cas9-mediated-multiplex-gene-editing-in-car-t-cells
#3
Xiaojuan Liu, Yongping Zhang, Chen Cheng, Albert W Cheng, Xingying Zhang, Na Li, Changqing Xia, Xiaofei Wei, Xiang Liu, Haoyi Wang
No abstract text is available yet for this article.
December 2, 2016: Cell Research
https://www.readbyqxmd.com/read/27910850/the-guanine-nucleotide-exchange-factor-net1-facilitates-the-specification-of-dorsal-cell-fates-in-zebrafish-embryos-by-promoting-maternal-%C3%AE-catenin-activation
#4
Shi Wei, Miaomiao Dai, Zhaoting Liu, Yuanqing Ma, Hanqiao Shang, Yu Cao, Qiang Wang
Wnt/β-catenin signaling is essential for the initiation of dorsal-ventral patterning during vertebrate embryogenesis. Maternal β-catenin accumulates in dorsal marginal nuclei during cleavage stages, but its critical target genes essential for dorsalization are silent until mid-blastula transition (MBT). Here, we find that zebrafish net1, a guanine nucleotide exchange factor, is specifically expressed in dorsal marginal blastomeres after MBT, and acts as a zygotic factor to promote the specification of dorsal cell fates...
December 2, 2016: Cell Research
https://www.readbyqxmd.com/read/27886168/hitting-the-right-button-mavs-mediated-defense-against-hav-infection
#5
Percy A Knolle
Studying the immune response against infection with hepatitis viruses is hampered by the lack of suitable preclinical model systems. A recent publication in Science identifies the cytosolic adapter molecule MAVS as being responsible for species restriction of infection with hepatitis A virus as well as linking cytosolic immune sensing in infected hepatocytes with innate effector functions and protective adaptive immunity.
November 25, 2016: Cell Research
https://www.readbyqxmd.com/read/27834347/a-new-target-for-differentiation-therapy-in-aml
#6
Peilin Ma, Weihua Song, Jay L Hess
Despite major advances in understanding the genetics and epigenetics of acute myelogenous leukemia, there is still a great need to develop more specific and effective therapies. High throughput approaches involving either genetic approaches or small molecule inhibitor screens are beginning to identify promising new therapeutic targets.
November 11, 2016: Cell Research
https://www.readbyqxmd.com/read/27834345/the-glial-actin-cytoskeleton-regulates-neuronal-ciliogenesis
#7
Hao Zhu, Lianwan Chen, Yihong Yang, Zhiwen Zhu, Xianliang Zhang, Wei Li, Long Miao, Yan Zhang, Guangshuo Ou
No abstract text is available yet for this article.
November 11, 2016: Cell Research
https://www.readbyqxmd.com/read/27824029/dna-methylation-and-chromatin-accessibility-profiling-of-mouse-and-human-fetal-germ-cells
#8
Hongshan Guo, Boqiang Hu, Liying Yan, Jun Yong, Yan Wu, Yun Gao, Fan Guo, Yu Hou, Xiaoying Fan, Ji Dong, Xiaoye Wang, Xiaohui Zhu, Jie Yan, Yuan Wei, Hongyan Jin, Wenxin Zhang, Lu Wen, Fuchou Tang, Jie Qiao
Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. We find 116 887 and 137 557 nucleosome-depleted regions (NDRs) in human and mouse FGCs, covering a large set of germline-specific and highly dynamic regulatory genomic elements, such as enhancers...
November 8, 2016: Cell Research
https://www.readbyqxmd.com/read/27767096/neuropeptide-signals-cell-non-autonomous-mitochondrial-unfolded-protein-response
#9
Li-Wa Shao, Rong Niu, Ying Liu
Neurons have a central role in the systemic coordination of mitochondrial unfolded protein response (UPR(mt)) and the cell non-autonomous modulation of longevity. However, the mechanism by which the nervous system senses mitochondrial stress and communicates to the distal tissues to induce UPR(mt) remains unclear. Here we employ the tissue-specific CRISPR-Cas9 approach to disrupt mitochondrial function only in the nervous system of Caenorhabditis elegans, and reveal a cell non-autonomous induction of UPR(mt) in peripheral cells...
October 21, 2016: Cell Research
https://www.readbyqxmd.com/read/27767095/inhibitory-phosphorylation-of-cdk1-mediates-prolonged-prophase-i-arrest-in-female-germ-cells-and-is-essential-for-female-reproductive-lifespan
#10
Deepak Adhikari, Kiran Busayavalasa, Jingjing Zhang, Mengwen Hu, Sanjiv Risal, Mustafa Bilal Bayazit, Meenakshi Singh, M Kasim Diril, Philipp Kaldis, Kui Liu
A unique feature of female germ cell development in mammals is their remarkably long arrest at the prophase of meiosis I, which lasts up to 50 years in humans. Both dormant and growing oocytes are arrested at prophase I and completely lack the ability to resume meiosis. Here, we show that the prolonged meiotic arrest of female germ cells is largely achieved via the inhibitory phosphorylation of Cdk1 (cyclin-dependent kinase 1). In two mouse models where we have introduced mutant Cdk1(T14AY15F) which cannot be inhibited by phosphorylation (Cdk1AF) in small meiotically incompetent oocytes, the prophase I arrest is interrupted, leading to a premature loss of female germ cells...
October 21, 2016: Cell Research
https://www.readbyqxmd.com/read/27767094/warm-feelings-for-trpm2
#11
Thomas Voets
Two recent studies reveal a crucial role for the cation channel TRPM2 in sensing warm temperatures, both in the thermoregulatory center of the brain and in the somatosensory system.
October 21, 2016: Cell Research
https://www.readbyqxmd.com/read/27767093/turning-rice-meiosis-into-mitosis
#12
Delphine Mieulet, Sylvie Jolivet, Maud Rivard, Laurence Cromer, Aurore Vernet, Pauline Mayonove, Lucie Pereira, Gaëtan Droc, Brigitte Courtois, Emmanuel Guiderdoni, Raphael Mercier
Introduction of clonal reproduction through seeds (apomixis) in crops has the potential to revolutionize agriculture by allowing self-propagation of any elite variety, in particular F1 hybrids. In the sexual model plant Arabidopsis thaliana synthetic clonal reproduction through seeds can be artificially implemented by (i) combining three mutations to turn meiosis into mitosis (MiMe) and (ii) crossing the obtained clonal gametes with a line expressing modified CENH3 and whose genome is eliminated in the zygote...
October 21, 2016: Cell Research
https://www.readbyqxmd.com/read/27752039/mechanisms-of-activation-and-inhibition-of-zika-virus-ns2b-ns3-protease
#13
Xia Chen, Kailin Yang, Chen Wu, Cheng Chen, Can Hu, Olga Buzovetsky, Zefang Wang, Xiaoyun Ji, Yong Xiong, Haitao Yang
No abstract text is available yet for this article.
October 18, 2016: Cell Research
https://www.readbyqxmd.com/read/27725674/multi-step-formation-evolution-and-functionalization-of-new-cytoplasmic-male-sterility-genes-in-the-plant-mitochondrial-genomes
#14
Huiwu Tang, Xingmei Zheng, Chuliang Li, Xianrong Xie, Yuanling Chen, Letian Chen, Xiucai Zhao, Huiqi Zheng, Jiajian Zhou, Shan Ye, Jingxin Guo, Yao-Guang Liu
New gene origination is a major source of genomic innovations that confer phenotypic changes and biological diversity. Generation of new mitochondrial genes in plants may cause cytoplasmic male sterility (CMS), which can promote outcrossing and increase fitness. However, how mitochondrial genes originate and evolve in structure and function remains unclear. The rice Wild Abortive type of CMS is conferred by the mitochondrial gene WA352c (previously named WA352) and has been widely exploited in hybrid rice breeding...
October 11, 2016: Cell Research
https://www.readbyqxmd.com/read/27686184/otulin-deficiency-causes-auto-inflammatory-syndrome
#15
Berthe Katrine Fiil, Mads Gyrd-Hansen
Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.
September 30, 2016: Cell Research
https://www.readbyqxmd.com/read/27670697/the-genome-wide-mutational-landscape-of-pituitary-adenomas
#16
Zhi-Jian Song, Zachary J Reitman, Zeng-Yi Ma, Jian-Hua Chen, Qi-Lin Zhang, Xue-Fei Shou, Chuan-Xin Huang, Yong-Fei Wang, Shi-Qi Li, Ying Mao, Liang-Fu Zhou, Bao-Feng Lian, Hai Yan, Yong-Yong Shi, Yao Zhao
No abstract text is available yet for this article.
September 27, 2016: Cell Research
https://www.readbyqxmd.com/read/27633062/a-new-edge-to-immune-surveillance-by-the-neural-system
#17
Jochem H Bernink, Hergen Spits, Wouter J de Jonge
A recent paper published in Nature demonstrates a multifaceted relation between enteric glial cells (EGC), intestinal epithelia, and ILC3, via the EGC release of neurotrophic factors, a structurally related group of ligands within the TGF-β superfamily of signaling molecules and IL-22 produced by ILC3.
September 16, 2016: Cell Research
https://www.readbyqxmd.com/read/27909292/crystal-structures-of-the-tric-trimeric-intracellular-cation-channel-orthologues
#18
Go Kasuya, Masahiro Hiraizumi, Andrés D Maturana, Kaoru Kumazaki, Yuichiro Fujiwara, Keihong Liu, Yoshiko Nakada-Nakura, So Iwata, Keisuke Tsukada, Tomotaka Komori, Sotaro Uemura, Yuhei Goto, Takanori Nakane, Mizuki Takemoto, Hideaki E Kato, Keitaro Yamashita, Miki Wada, Koichi Ito, Ryuichiro Ishitani, Motoyuki Hattori, Osamu Nureki
Ca(2+) release from the sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) is crucial for muscle contraction, cell growth, apoptosis, learning and memory. The trimeric intracellular cation (TRIC) channels were recently identified as cation channels balancing the SR and ER membrane potentials, and are implicated in Ca(2+) signaling and homeostasis. Here we present the crystal structures of prokaryotic TRIC channels in the closed state and structure-based functional analyses of prokaryotic and eukaryotic TRIC channels...
December 2016: Cell Research
https://www.readbyqxmd.com/read/27886169/the-mitokine-quest-ion
#19
Pan Deng, Cole M Haynes
Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPR), which is regulated by mitochondrial-to-nuclear communication; and UPR activation can also be transmitted between different cell types suggesting a role in tissue coordination. Shao and colleagues now identify a neuronal circuit and a secreted neuropeptide required for cell non-autonomous UPR regulation.
December 2016: Cell Research
https://www.readbyqxmd.com/read/27886167/mapping-of-long-range-chromatin-interactions-by-proximity-ligation-assisted-chip-seq
#20
Rongxin Fang, Miao Yu, Guoqiang Li, Sora Chee, Tristin Liu, Anthony D Schmitt, Bing Ren
No abstract text is available yet for this article.
December 2016: Cell Research
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