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Cell Research

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https://www.readbyqxmd.com/read/30218061/staged-profiling-of-sperm-development-in-sync
#1
Navin B Ramakrishna, M Azim Surani
No abstract text is available yet for this article.
September 14, 2018: Cell Research
https://www.readbyqxmd.com/read/30218060/cgas-activation-in-phased-droplets
#2
Yongbo Liu, Hua-Bing Li, Richard A Flavell
No abstract text is available yet for this article.
September 14, 2018: Cell Research
https://www.readbyqxmd.com/read/30209352/a-post-ingestive-amino-acid-sensor-promotes-food-consumption-in-drosophila
#3
Zhe Yang, Rui Huang, Xin Fu, Gaohang Wang, Wei Qi, Decai Mao, Zhaomei Shi, Wei L Shen, Liming Wang
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By using a quantitative feeding assay, we show that three amino acids, L-glutamate (L-Glu), L-alanine (L-Ala) and L-aspartate (L-Asp), but not their D-enantiomers or the other 17 natural L-amino acids combined, rapidly promote food consumption in the fruit fly Drosophila melanogaster. This feeding-promoting effect of dietary amino acids is independent of mating experience and internal nutritional status...
September 12, 2018: Cell Research
https://www.readbyqxmd.com/read/30171189/guiding-a-mutator-in-antibody-diversification
#4
Ming Tian, Frederick W Alt
No abstract text is available yet for this article.
August 31, 2018: Cell Research
https://www.readbyqxmd.com/read/30150673/loss-of-ythdf2-mediated-m-6-a-dependent-mrna-clearance-facilitates-hematopoietic-stem-cell-regeneration
#5
LETTER
Hu Wang, Hongna Zuo, Jin Liu, Fei Wen, Yawei Gao, Xudong Zhu, Bo Liu, Feng Xiao, Wengong Wang, Gang Huang, Bin Shen, Zhenyu Ju
No abstract text is available yet for this article.
August 27, 2018: Cell Research
https://www.readbyqxmd.com/read/30150672/author-correction-suppression-of-m-6-a-reader-ythdf2-promotes-hematopoietic-stem-cell-expansion
#6
Zhenrui Li, Pengxu Qian, Wanqing Shao, Hailing Shi, Xi C He, Madelaine Gogol, Zulin Yu, Yongfu Wang, Meijie Qi, Yunfei Zhu, John M Perry, Kai Zhang, Fang Tao, Kun Zhou, Deqing Hu, Yingli Han, Chongbei Zhao, Richard Alexander, Hanzhang Xu, Shiyuan Chen, Allison Peak, Kathyrn Hall, Michael Peterson, Anoja Perera, Jeffrey S Haug, Tari Parmely, Hua Li, Bin Shen, Julia Zeitlinger, Chuan He, Linheng Li
In the initial published version of this article, there was an inadvertent omission from the Acknowledgements that this work was supported by Stowers Institute for Medical Research (SIMR-1004) and NIH National Cancer Institute grant to University of Kansas Cancer Center (P30 CA168524). This omission does not affect the description of the results or the conclusions of this work.
August 27, 2018: Cell Research
https://www.readbyqxmd.com/read/30143796/the-rna-binding-protein-rod1-ptbp3-cotranscriptionally-defines-aid-loading-sites-to-mediate-antibody-class-switch-in-mammalian-genomes
#7
Juan Chen, Zhaokui Cai, Meizhu Bai, Xiaohua Yu, Chao Zhang, Changchang Cao, Xihao Hu, Lei Wang, Ruibao Su, Di Wang, Lei Wang, Yingpeng Yao, Rong Ye, Baidong Hou, Yang Yu, Shuyang Yu, Jinsong Li, Yuanchao Xue
Activation-induced cytidine deaminase (AID) mediates class switching by binding to a small fraction of single-stranded DNA (ssDNA) to diversify the antibody repertoire. The precise mechanism for highly selective AID targeting in the genome has remained elusive. Here, we report an RNA-binding protein, ROD1 (also known as PTBP3), that is both required and sufficient to define AID-binding sites genome-wide in activated B cells. ROD1 interacts with AID via an ultraconserved loop, which proves to be critical for the recruitment of AID to ssDNA using bi-directionally transcribed nascent RNAs as stepping stones...
August 24, 2018: Cell Research
https://www.readbyqxmd.com/read/30127373/stat3-associates-with-vacuolar-h-atpase-and-regulates-cytosolic-and-lysosomal-ph
#8
Bin Liu, Johan Palmfeldt, Lin Lin, Alexandria Colaço, Knut K B Clemmensen, Jinrong Huang, Fengping Xu, Xin Liu, Kenji Maeda, Yonglun Luo, Marja Jäättelä
Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production, cancer cells maintain alkaline intracellular pH that promotes cancer progression by inhibiting apoptosis and increasing glycolysis, cell growth, migration, and invasion. Here we identify signal transducer and activator of transcription-3 (STAT3) as a key factor in the preservation of alkaline cytosol. STAT3 associates with the vacuolar H+ -ATPase in a coiled-coil domain-dependent manner and increases its activity in living cells and in vitro...
August 20, 2018: Cell Research
https://www.readbyqxmd.com/read/30108290/skeletal-muscle-mitochondrial-remodeling-in-exercise-and-diseases
#9
Zhenji Gan, Tingting Fu, Daniel P Kelly, Rick B Vega
Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial dysfunction has been implicated in the pathogenesis of many diseases, including muscular dystrophy, atrophy, type 2 diabetes, and aging-related sarcopenia. Notably, exercise counteracts the effects of many chronic diseases on skeletal muscle mitochondrial function...
August 14, 2018: Cell Research
https://www.readbyqxmd.com/read/30030519/structure-of-the-intact-14-subunit-human-cytochrome-c-oxidase
#10
Shuai Zong, Meng Wu, Jinke Gu, Tianya Liu, Runyu Guo, Maojun Yang
Respiration is one of the most basic features of living organisms, and the electron transport chain complexes are probably the most complicated protein system in mitochondria. Complex-IV is the terminal enzyme of the electron transport chain, existing either as randomly scattered complexes or as a component of supercomplexes. NDUFA4 was previously assumed as a subunit of complex-I, but recent biochemical data suggested it may be a subunit of complex-IV. However, no structural evidence supporting this notion was available till now...
July 20, 2018: Cell Research
https://www.readbyqxmd.com/read/30006613/mettl3-mettl14-methyltransferase-complex-regulates-the-quiescence-of-adult-hematopoietic-stem-cells
#11
LETTER
Qi Jason Yao, Lina Sang, Minghui Lin, Xiujuan Yin, Wenjie Dong, Yuping Gong, Bo O Zhou
No abstract text is available yet for this article.
July 13, 2018: Cell Research
https://www.readbyqxmd.com/read/29976953/threshold-for-neural-tube-defect-risk-by-accumulated-singleton-loss-of-function-variants
#12
LETTER
Zhongzhong Chen, Yunping Lei, Yufang Zheng, Vanessa Aguiar-Pulido, M Elizabeth Ross, Rui Peng, Li Jin, Ting Zhang, Richard H Finnell, Hongyan Wang
No abstract text is available yet for this article.
July 5, 2018: Cell Research
https://www.readbyqxmd.com/read/30140029/cryo-em-structure-of-the-human-%C3%AE-5%C3%AE-3-gaba-a-receptor
#13
LETTER
Si Liu, Lingyi Xu, Fenghui Guan, Yun-Tao Liu, Yanxiang Cui, Qing Zhang, Xiang Zheng, Guo-Qiang Bi, Z Hong Zhou, Xiaokang Zhang, Sheng Ye
No abstract text is available yet for this article.
September 2018: Cell Research
https://www.readbyqxmd.com/read/30135474/imbalance-of-the-reciprocally-inhibitory-loop-between-the-ubiquitin-specific-protease-usp43-and-egfr-pi3k-akt-drives-breast-carcinogenesis
#14
Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Chengjian Guan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Rong Liu, Luyang Sun, Yongfeng Shang
Hyperactivation of EGFR/PI3K/AKT is a prominent feature of various human cancers. Thus, understanding how this molecular cascade is balanced is of great importance. We report here that the ubiquitin-specific protease USP43 is physically associated with the chromatin remodeling NuRD complex and catalyzes H2BK120 deubiquitination. Functionally this coordinates the NuRD complex to repress a cohort of genes, including EGFR, which are critically involved in cell proliferation and carcinogenesis. We show that USP43 strongly suppresses the growth and metastasis of breast cancer in vivo...
September 2018: Cell Research
https://www.readbyqxmd.com/read/30131512/m-6-a-reader-suppression-bolsters-hsc-expansion
#15
Xinxin Huang, Hal E Broxmeyer
No abstract text is available yet for this article.
September 2018: Cell Research
https://www.readbyqxmd.com/read/30065316/amyloid-fibril-structure-of-%C3%AE-synuclein-determined-by-cryo-electron-microscopy
#16
Yaowang Li, Chunyu Zhao, Feng Luo, Zhenying Liu, Xinrui Gui, Zhipu Luo, Xiang Zhang, Dan Li, Cong Liu, Xueming Li
α-Synuclein (α-syn) amyloid fibrils are the major component of Lewy bodies, which are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. High-resolution structure of α-syn fibril is important for understanding its assembly and pathological mechanism. Here, we determined a fibril structure of full-length α-syn (1-140) at the resolution of 3.07 Å by cryo-electron microscopy (cryo-EM). The fibrils are cytotoxic, and transmissible to induce endogenous α-syn aggregation in primary neurons...
September 2018: Cell Research
https://www.readbyqxmd.com/read/30065315/suppression-of-m-6-a-reader-ythdf2-promotes-hematopoietic-stem-cell-expansion
#17
Zhenrui Li, Pengxu Qian, Wanqing Shao, Hailing Shi, Xi C He, Madelaine Gogol, Zulin Yu, Yongfu Wang, Meijie Qi, Yunfei Zhu, John M Perry, Kai Zhang, Fang Tao, Kun Zhou, Deqing Hu, Yingli Han, Chongbei Zhao, Richard Alexander, Hanzhang Xu, Shiyuan Chen, Allison Peak, Kathyrn Hall, Michael Peterson, Anoja Perera, Jeffrey S Haug, Tari Parmely, Hua Li, Bin Shen, Julia Zeitlinger, Chuan He, Linheng Li
Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB) holds great promise for treating a broad spectrum of hematological disorders including cancer. However, the limited number of HSCs in a single hUCB unit restricts its widespread use. Although extensive efforts have led to multiple methods for ex vivo expansion of human HSCs by targeting single molecules or pathways, it remains unknown whether it is possible to simultaneously manipulate the large number of targets essential for stem cell self-renewal...
September 2018: Cell Research
https://www.readbyqxmd.com/read/30061742/single-cell-rna-seq-uncovers-dynamic-processes-and-critical-regulators-in-mouse-spermatogenesis
#18
Yao Chen, Yuxuan Zheng, Yun Gao, Zhen Lin, Suming Yang, Tongtong Wang, Qiu Wang, Nannan Xie, Rong Hua, Mingxi Liu, Jiahao Sha, Michael D Griswold, Jinsong Li, Fuchou Tang, Ming-Han Tong
A systematic interrogation of male germ cells is key to complete understanding of molecular mechanisms governing spermatogenesis and the development of new strategies for infertility therapies and male contraception. Here we develop an approach to purify all types of homogeneous spermatogenic cells by combining transgenic labeling and synchronization of the cycle of the seminiferous epithelium, and subsequent single-cell RNA-sequencing. We reveal extensive and previously uncharacterized dynamic processes and molecular signatures in gene expression, as well as specific patterns of alternative splicing, and novel regulators for specific stages of male germ cell development...
September 2018: Cell Research
https://www.readbyqxmd.com/read/30046135/m-6-a-rna-modification-controls-autophagy-through-upregulating-ulk1-protein-abundance
#19
LETTER
Shouheng Jin, Xiya Zhang, Yanyan Miao, Puping Liang, Kaiyu Zhu, Yuanchu She, Yaoxing Wu, Di-Ao Liu, Junjiu Huang, Jian Ren, Jun Cui
No abstract text is available yet for this article.
September 2018: Cell Research
https://www.readbyqxmd.com/read/30042383/p53-reeps-to-sow-er-mitochondrial-contacts
#20
Florian J Bock, Stephen W G Tait
No abstract text is available yet for this article.
September 2018: Cell Research
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