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Cell Research

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https://www.readbyqxmd.com/read/29148543/endothelial-specific-m-6-a-modulates-mouse-hematopoietic-stem-and-progenitor-cell-development-via-notch-signaling
#1
Junhua Lv, Yifan Zhang, Suwei Gao, Chunxia Zhang, Yusheng Chen, Wei Li, Yun-Gui Yang, Qi Zhou, Feng Liu
No abstract text is available yet for this article.
November 17, 2017: Cell Research
https://www.readbyqxmd.com/read/29148542/prrt2-dependent-dyskinesia-cerebellar-paroxysmal-and-persistent
#2
Lieke Kros, Chris I De Zeeuw
In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity patterns of Purkinje cells, the sole output of the cerebellar cortex.
November 17, 2017: Cell Research
https://www.readbyqxmd.com/read/29148541/integrated-genomic-analysis-identifies-deregulated-jak-stat-myc-biosynthesis-axis-in-aggressive-nk-cell-leukemia
#3
Liang Huang, Dan Liu, Na Wang, Shaoping Ling, Yuting Tang, Jun Wu, Lingtong Hao, Hui Luo, Xuelian Hu, Lingshuang Sheng, Lijun Zhu, Di Wang, Yi Luo, Zhen Shang, Min Xiao, Xia Mao, Kuangguo Zhou, Lihua Cao, Lili Dong, Xinchang Zheng, Pinpin Sui, Jianlin He, Shanlan Mo, Jin Yan, Qilin Ao, Lugui Qiu, Hongsheng Zhou, Qifa Liu, Hongyu Zhang, Jianyong Li, Jie Jin, Li Fu, Weili Zhao, Jieping Chen, Xin Du, Guoliang Qing, Hudan Liu, Xin Liu, Gang Huang, Ding Ma, Jianfeng Zhou, Qian-Fei Wang
Aggressive NK-cell leukemia (ANKL) is a rare form of NK cell neoplasm that is more prevalent among people from Asia and Central and South America. Patients usually die within days to months, even after receiving prompt therapeutic management. Here we performed the first comprehensive study of ANKL by integrating whole genome, transcriptome and targeted sequencing, cytokine array as well as functional assays. Mutations in the JAK-STAT pathway were identified in 48% (14/29) of ANKL patients, while the extracellular STAT3 stimulator IL10 was elevated by an average of 56-fold (P < 0...
November 17, 2017: Cell Research
https://www.readbyqxmd.com/read/29134957/hunting-for-the-mutant-without-the-map-k
#4
Leon Tejwani, Janghoo Lim
In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington's disease (HD) pathology. The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.
November 14, 2017: Cell Research
https://www.readbyqxmd.com/read/29134956/the-11th-c2h2-zinc-finger-and-an-adjacent-c-terminal-arm-are-responsible-for-tzap-recognition-of-telomeric-dna
#5
Yaqing Zhao, Guang Zhang, Chao He, Yide Mei, Yunyu Shi, Fudong Li
No abstract text is available yet for this article.
November 14, 2017: Cell Research
https://www.readbyqxmd.com/read/29125140/mouse-embryonic-stem-cells-have-increased-capacity-for-replication-fork-restart-driven-by-the-specific-filia-floped-protein-complex
#6
Bo Zhao, Weidao Zhang, Yixian Cun, Jingzheng Li, Yan Liu, Jing Gao, Hongwen Zhu, Hu Zhou, Rugang Zhang, Ping Zheng
Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSCs. Here, we report that mouse embryonic stem cells (ESCs) are superior to differentiated cells in resolving replication stress. Specifically, ESCs utilize a unique Filia-Floped protein complex-dependent mechanism to efficiently promote the restart of stalled replication forks, therefore maintaining genomic stability...
November 10, 2017: Cell Research
https://www.readbyqxmd.com/read/29099092/human-embryonic-stem-cells-contribute-to-embryonic-and-extraembryonic-lineages-in-mouse-embryos-upon-inhibition-of-apoptosis
#7
Xuepeng Wang, Tianda Li, Tongtong Cui, Dawei Yu, Chao Liu, Liyuan Jiang, Guihai Feng, Lei Wang, Rui Fu, Xinxin Zhang, Jie Hao, Yukai Wang, Liu Wang, Qi Zhou, Wei Li, Baoyang Hu
No abstract text is available yet for this article.
November 3, 2017: Cell Research
https://www.readbyqxmd.com/read/29086765/endothelial-cell-derived-gaba-signaling-modulates-neuronal-migration-and-postnatal-behavior
#8
Suyan Li, Peeyush Kumar T, Sampada Joshee, Timo Kirschstein, Sivan Subburaju, Jahan S Khalili, Jonas Kloepper, Chuang Du, Abdallah Elkhal, Gábor Szabó, Rakesh K Jain, Rüdiger Köhling, Anju Vasudevan
The cerebral cortex is essential for integration and processing of information that is required for most behaviors. The exquisitely precise laminar organization of the cerebral cortex arises during embryonic development when neurons migrate successively from ventricular zones to coalesce into specific cortical layers. While radial glia act as guide rails for projection neuron migration, pre-formed vascular networks provide support and guidance cues for GABAergic interneuron migration. This study provides novel conceptual and mechanistic insights into this paradigm of vascular-neuronal interactions, revealing new mechanisms of GABA and its receptor-mediated signaling via embryonic forebrain endothelial cells...
October 31, 2017: Cell Research
https://www.readbyqxmd.com/read/29086764/a-circular-twist-on-microrna-regulation
#9
Marco Bezzi, Jlenia Guarnerio, Pier Paolo Pandolfi
Circular RNAs (circRNAs) are a novel class of RNA whose physiological function has yet to be investigated. A recent publication in Science provides the first evidence of the biological relevance of a circRNA in an in vivo model and unveils an unexpected twist on their crosstalk with miRNAs.
October 31, 2017: Cell Research
https://www.readbyqxmd.com/read/29076503/excessive-ube3a-dosage-impairs-retinoic-acid-signaling-and-synaptic-plasticity-in-autism-spectrum-disorders
#10
Xingxing Xu, Chuanyin Li, Xiaobo Gao, Kun Xia, Hui Guo, Yali Li, Zijian Hao, Lei Zhang, Daming Gao, Chenfan Xu, Huatai Xu, Zhi-Qi Xiong, Zilong Qiu, Ling Mei, Xiaoduo Xie, Kangcheng Ruan, Ronggui Hu
The autism spectrum disorders (ASDs) are a collection of human neurological disorders with heterogeneous etiologies. Hyperactivity of E3 ubiquitin (Ub) ligase UBE3A, stemming from 15q11-q13 copy number variations, accounts for 1%-3% of ASD cases worldwide, but the underlying mechanisms remain incompletely characterized. Here we report that the functionality of ALDH1A2, the rate-limiting enzyme of retinoic acid (RA) synthesis, is negatively regulated by UBE3A in a ubiquitylation-dependent manner. Excessive UBE3A dosage was found to impair RA-mediated neuronal homeostatic synaptic plasticity...
October 27, 2017: Cell Research
https://www.readbyqxmd.com/read/29076502/derivation-of-hypermethylated-pluripotent-embryonic-stem-cells-with-high-potency
#11
Siqin Bao, Walfred Wc Tang, Baojiang Wu, Shinseog Kim, Jingyun Li, Lin Li, Toshihiro Kobayashi, Caroline Lee, Yanglin Chen, Mengyi Wei, Shudong Li, Sabine Dietmann, Fuchou Tang, Xihe Li, M Azim Surani
Naive hypomethylated embryonic pluripotent stem cells (ESCs) are developmentally closest to the preimplantation epiblast of blastocysts, with the potential to contribute to all embryonic tissues and the germline, excepting the extra-embryonic tissues in chimeric embryos. By contrast, epiblast stem cells (EpiSCs) resembling postimplantation epiblast are relatively more methylated and show a limited potential for chimerism. Here, for the first time, we reveal advanced pluripotent stem cells (ASCs), which are developmentally beyond the pluripotent cells in the inner cell mass but with higher potency than EpiSCs...
October 27, 2017: Cell Research
https://www.readbyqxmd.com/read/29076500/plasma-membrane-changes-during-programmed-cell-deaths
#12
REVIEW
Yingying Zhang, Xin Chen, Cyril Gueydan, Jiahuai Han
Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic and apoptotic cell death, respectively. As such, apoptosis is usually considered a non-inflammatory process while necrosis triggers inflammation. Recent studies on necroptosis and pyroptosis, two types of programmed necrosis, revealed that plasma membrane rupture is mediated by MLKL channels during necroptosis but depends on non-selective gasdermin D (GSDMD) pores during pyroptosis. Importantly, the morphology of dying cells executed by MLKL channels can be distinguished from that executed by GSDMD pores...
October 27, 2017: Cell Research
https://www.readbyqxmd.com/read/29056748/wnt-induced-vangl2-phosphorylation-is-dose-dependently-required-for-planar-cell-polarity-in-mammalian-development
#13
Wei Yang, Lisa Garrett, Di Feng, Gene Elliott, Xilin Liu, Ni Wang, Yu Ming Wong, Nga Ting Choi, Yingzi Yang, Bo Gao
Planar cell polarity (PCP) is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behavior during embryonic development. Disruption of PCP leads to severe morphological defects in vertebrates and its dysregulation results in a variety of human diseases such as neural tube defects and skeletal dysplasia. PCP is governed by a set of highly conserved core proteins that are asymmetrically localized at the cell surface throughout the polarized tissues...
October 20, 2017: Cell Research
https://www.readbyqxmd.com/read/29056747/prrt2-deficiency-induces-paroxysmal-kinesigenic-dyskinesia-by-regulating-synaptic-transmission-in-cerebellum
#14
Guo-He Tan, Yuan-Yuan Liu, Lu Wang, Kui Li, Ze-Qiang Zhang, Hong-Fu Li, Zhong-Fei Yang, Yang Li, Dan Li, Ming-Yue Wu, Chun-Lei Yu, Juan-Juan Long, Ren-Chao Chen, Li-Xi Li, Lu-Ping Yin, Ji-Wei Liu, Xue-Wen Cheng, Qi Shen, You-Sheng Shu, Kenji Sakimura, Lu-Jian Liao, Zhi-Ying Wu, Zhi-Qi Xiong
Mutations in the proline-rich transmembrane protein 2 (PRRT2) are associated with paroxysmal kinesigenic dyskinesia (PKD) and several other paroxysmal neurological diseases, but the PRRT2 function and pathogenic mechanisms remain largely obscure. Here we show that PRRT2 is a presynaptic protein that interacts with components of the SNARE complex and downregulates its formation. Loss-of-function mutant mice showed PKD-like phenotypes triggered by generalized seizures, hyperthermia, or optogenetic stimulation of the cerebellum...
October 20, 2017: Cell Research
https://www.readbyqxmd.com/read/28961230/structural-basis-for-bir1-mediated-negative-regulation-of-plant-immunity
#15
Cuiyan Ma, Yanan Liu, Bing Bai, Zhifu Han, Jiao Tang, Heqiao Zhang, Hoda Yaghmaiean, Yuelin Zhang, Jijie Chai
No abstract text is available yet for this article.
September 29, 2017: Cell Research
https://www.readbyqxmd.com/read/28925385/fine-tuning-type-i-ifn-signaling-a-new-chapter-in-the-ifn-saga
#16
Hideyuki Yanai, Tadatsugu Taniguchi
Type I interferon (IFN) signaling is critical for intracellular antimicrobial programmes, affecting both innate and adaptive immune responses. The paper recently published in Cell demonstrates a new regulatory mechanism of the type I IFN signaling pathway by histone-lysine N-methyltransferase SETD2.
September 19, 2017: Cell Research
https://www.readbyqxmd.com/read/29097740/white-adipose-tissue-coloring-by-intermittent-fasting
#17
Riikka Kivelä, Kari Alitalo
Intermittent fasting (IF) has been shown to promote metabolic health in several organisms. Two recent papers show that IF induces white adipose tissue beiging and increases thermogenesis, which improves metabolic health in mice.
November 2017: Cell Research
https://www.readbyqxmd.com/read/29097739/sanofi-cell-research-outstanding-paper-award-of-2016
#18
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Cell Research
https://www.readbyqxmd.com/read/29076501/molecular-mechanism-of-directional-ctcf-recognition-of-a-diverse-range-of-genomic-sites
#19
Maolu Yin, Jiuyu Wang, Min Wang, Xinmei Li, Mo Zhang, Qiang Wu, Yanli Wang
CTCF, a conserved 3D genome architecture protein, determines proper genome-wide chromatin looping interactions through directional binding to specific sequence elements of four modules within numerous CTCF-binding sites (CBSs) by its 11 zinc fingers (ZFs). Here, we report four crystal structures of human CTCF in complex with CBSs of the protocadherin (Pcdh) clusters. We show that directional CTCF binding to cognate CBSs of the Pcdh enhancers and promoters is achieved through inserting its ZF3, ZFs 4-7, and ZFs 9-11 into the major groove along CBSs, resulting in a sequence-specific recognition of module 4, modules 3 and 2, and module 1, respectively; and ZF8 serves as a spacer element for variable distances between modules 1 and 2...
November 2017: Cell Research
https://www.readbyqxmd.com/read/29039412/intermittent-fasting-promotes-adipose-thermogenesis-and-metabolic-homeostasis-via-vegf-mediated-alternative-activation-of-macrophage
#20
Kyoung-Han Kim, Yun Hye Kim, Joe Eun Son, Ju Hee Lee, Sarah Kim, Min Seon Choe, Joon Ho Moon, Jian Zhong, Kiya Fu, Florine Lenglin, Jeong-Ah Yoo, Philip J Bilan, Amira Klip, Andras Nagy, Jae-Ryong Kim, Jin Gyoon Park, Samer Mi Hussein, Kyung-Oh Doh, Chi-Chung Hui, Hoon-Ki Sung
Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT)...
November 2017: Cell Research
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