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Cell Research

Yongting Luo, Hongxia Duan, Yining Qian, Liqun Feng, Zhenzhen Wu, Fei Wang, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan
The persistence of cholesterol-engorged macrophages (foam cells) in the artery wall fuels the development of atherosclerosis. However, the mechanism that regulates the formation of macrophage foam cells and impedes their emigration out of inflamed plaques is still elusive. Here, we report that adhesion receptor CD146 controls the formation of macrophage foam cells and their retention within the plaque during atherosclerosis exacerbation. CD146 is expressed on the macrophages in human and mouse atheroma and can be upregulated by oxidized low-density lipoprotein (oxLDL)...
January 13, 2017: Cell Research
Li Zhang, Xiaojing Wang, Fenghui Fan, Hong-Wei Wang, Jiawei Wang, Xueming Li, Sen-Fang Sui
No abstract text is available yet for this article.
January 13, 2017: Cell Research
Blake Wiedenheft, Joseph Bondy-Denomy
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes (cas) are essential components of an adaptive immune system that protects bacteria and archaea from viral infection. Now a recent paper published in Cell Research suggests that the Type I-F immune system in Pseudomonas aeruginosa may also be involved in post-transcriptional regulation of virulence.
January 13, 2017: Cell Research
Feng Wang, Xing Fu, Peng Chen, Ping Wu, Xiaojuan Fan, Na Li, Hong Zhu, Ting-Ting Jia, Hongbin Ji, Zefeng Wang, Catherine C L Wong, Ronggui Hu, Jingyi Hui
Extracellular signals have been shown to impact on alternative pre-mRNA splicing; however, the molecular mechanisms and biological significance of signal-induced splicing regulation remain largely unknown. Here, we report that epidermal growth factor (EGF) induces splicing changes through ubiquitylation of a well-known splicing regulator, hnRNP A1. EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked polyUb chains onto hnRNP A1...
January 13, 2017: Cell Research
Yuexin Zhou, Ping Wang, Feng Tian, Ge Gao, Lei Huang, Wensheng Wei, X Sunney Xie
No abstract text is available yet for this article.
January 13, 2017: Cell Research
Yuchen Feng, Daniel J Klionsky
One of the key questions regarding macroautophagy/autophagy is the mechanism through which the transmembrane protein ATG9 functions in delivering membrane to the expanding phagophore, the sequestering compartment that matures into an autophagosome. In a recent study, Zhou et al. identified a novel mechanism that regulates ATG9 trafficking from the plasma membrane and trans-Golgi network, which involves two conserved sorting signals required for ATG9 interaction with the AP1/2 adaptor complex and phosphorylation of ATG9 at Tyr8 by SRC kinase and at Ser14 by ULK1 for proper function during basal and starvation-induced autophagy...
January 10, 2017: Cell Research
Dewei Wu, Tiancong Qi, Wan-Xiang Li, Haixia Tian, Hua Gao, Jiaojiao Wang, Jin Ge, Ruifeng Yao, Chunmei Ren, Xian-Bing Wang, Yule Liu, Le Kang, Shou-Wei Ding, Daoxin Xie
Some plant and animal pathogens can manipulate their hosts to cause them to release odors that are attractive to the pathogens' arthropod vectors. However, the molecular mechanism underlying this process is largely unexplored, and the specific effectors the pathogens employ as well as the pathways within the hosts they target are currently unknown. Here we reveal that the aphid-borne cucumber mosaic virus (CMV) employs its 2b protein, a well-characterized viral suppressor of host RNA interference (VSR), to target the host's jasmonate (JA) hormone pathway, thus acting as a viral inducer of host attractiveness to insect vectors (VIA)...
January 6, 2017: Cell Research
Ruifeng Yao, Fei Wang, Zhenhua Ming, Xiaoxi Du, Li Chen, Yupei Wang, Wenhao Zhang, Haiteng Deng, Daoxin Xie
No abstract text is available yet for this article.
January 6, 2017: Cell Research
Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yang
Pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays an important role in tumor cell proliferation. Recent studies have reported that PKM2 also regulates apoptosis. However, the mechanisms underlying such a role of PKM2 remain elusive. Here we show that PKM2 translocates to mitochondria under oxidative stress. In the mitochondria, PKM2 interacts with and phosphorylates Bcl2 at threonine (T) 69. This phosphorylation prevents the binding of Cul3-based E3 ligase to Bcl2 and subsequent degradation of Bcl2...
December 30, 2016: Cell Research
Fan Xu, Mingshu Zhang, Wenting He, Renmin Han, Fudong Xue, Zhiyong Liu, Fa Zhang, Jennifer Lippincott-Schwartz, Pingyong Xu
No abstract text is available yet for this article.
December 30, 2016: Cell Research
Chao-Hui Li, Lan-Zhen Yan, Wen-Zan Ban, Qiu Tu, Yong Wu, Lin Wang, Rui Bi, Shuang Ji, Yu-Hua Ma, Wen-Hui Nie, Long-Bao Lv, Yong-Gang Yao, Xu-Dong Zhao, Ping Zheng
Tree shrews have a close relationship to primates and have many advantages over rodents in biomedical research. However, the lack of gene manipulation methods has hindered the wider use of this animal. Spermatogonial stem cells (SSCs) have been successfully expanded in culture to permit sophisticated gene editing in the mouse and rat. Here, we describe a culture system for the long-term expansion of tree shrew SSCs without the loss of stem cell properties. In our study, thymus cell antigen 1 was used to enrich tree shrew SSCs...
December 23, 2016: Cell Research
Chong Li, Song Wu, Zhao Yang, Xiaolong Zhang, Qi Zheng, Ling Lin, Zexiong Niu, Ruiqiang Li, Zhiming Cai, Lei Li
No abstract text is available yet for this article.
December 16, 2016: Cell Research
Jung Jin Kim, Seung Baek Lee, Sang-Yeop Yi, Sang-Ah Han, Sun-Hyun Kim, Jong-Min Lee, Seo-Yun Tong, Ping Yin, Bowen Gao, Jun Zhang, Zhenkun Lou
Oncogene-induced senescence (OIS) or apoptosis through the DNA-damage response is an important barrier of tumorigenesis. Overcoming this barrier leads to abnormal cell proliferation, genomic instability, and cellular transformation, and finally allows cancers to develop. However, it remains unclear how the OIS barrier is overcome. Here, we show that the E3 ubiquitin ligase WD repeat and SOCS box-containing protein 1 (WSB1) plays a role in overcoming OIS. WSB1 expression in primary cells helps the bypass of OIS, leading to abnormal proliferation and cellular transformation...
December 13, 2016: Cell Research
Cheng-Guo Duan, Xingang Wang, Shaojun Xie, Li Pan, Daisuke Miki, Kai Tang, Chuan-Chih Hsu, Mingguang Lei, Yingli Zhong, Yueh-Ju Hou, Zhijuan Wang, Zhengjing Zhang, Satendra K Mangrauthia, Huawei Xu, Heng Zhang, Brian Dilkes, W Andy Tao, Jian-Kang Zhu
Transposons are generally kept silent by epigenetic mechanisms including DNA methylation. Here, we identified a pair of Harbinger transposon-derived proteins (HDPs), HDP1 and HDP2, as anti-silencing factors in Arabidopsis. hdp1 and hdp2 mutants displayed an enhanced silencing of transgenes and some transposons. Phylogenetic analyses revealed that HDP1 and HDP2 were co-domesticated from the Harbinger transposon-encoded transposase and DNA-binding protein, respectively. HDP1 interacts with HDP2 in the nucleus, analogous to their transposon counterparts...
December 9, 2016: Cell Research
Changqian Zhou, Kaili Ma, Ruize Gao, Chenglong Mu, Linbo Chen, Qiangqiang Liu, Qian Luo, Du Feng, Yushan Zhu, Quan Chen
Autophagy requires diverse membrane sources and involves membrane trafficking of mATG9, the only membrane protein in the ATG family. However, the molecular regulation of mATG9 trafficking for autophagy initiation remains unclear. Here we identified two conserved classic adaptor protein sorting signals within the cytosolic N-terminus of mATG9, which mediate trafficking of mATG9 from the plasma membrane and trans-Golgi network (TGN) via interaction with the AP1/2 complex. Src phosphorylates mATG9 at Tyr8 to maintain its endocytic and constitutive trafficking in unstressed conditions...
December 9, 2016: Cell Research
Yuting Chen, Ji Ma, Wenqing Lu, Meilin Tian, Marion Thauvin, Chonggang Yuan, Michel Volovitch, Qian Wang, Jeff Holst, Mingyao Liu, Sophie Vriz, Shixin Ye, Lei Wang, Dali Li
No abstract text is available yet for this article.
December 9, 2016: Cell Research
Shi Wei, Miaomiao Dai, Zhaoting Liu, Yuanqing Ma, Hanqiao Shang, Yu Cao, Qiang Wang
Wnt/β-catenin signaling is essential for the initiation of dorsal-ventral patterning during vertebrate embryogenesis. Maternal β-catenin accumulates in dorsal marginal nuclei during cleavage stages, but its critical target genes essential for dorsalization are silent until mid-blastula transition (MBT). Here, we find that zebrafish net1, a guanine nucleotide exchange factor, is specifically expressed in dorsal marginal blastomeres after MBT, and acts as a zygotic factor to promote the specification of dorsal cell fates...
December 2, 2016: Cell Research
Hao Zhu, Lianwan Chen, Yihong Yang, Zhiwen Zhu, Xianliang Zhang, Wei Li, Long Miao, Yan Zhang, Guangshuo Ou
No abstract text is available yet for this article.
November 11, 2016: Cell Research
Hongshan Guo, Boqiang Hu, Liying Yan, Jun Yong, Yan Wu, Yun Gao, Fan Guo, Yu Hou, Xiaoying Fan, Ji Dong, Xiaoye Wang, Xiaohui Zhu, Jie Yan, Yuan Wei, Hongyan Jin, Wenxin Zhang, Lu Wen, Fuchou Tang, Jie Qiao
Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. We find 116 887 and 137 557 nucleosome-depleted regions (NDRs) in human and mouse FGCs, covering a large set of germline-specific and highly dynamic regulatory genomic elements, such as enhancers...
November 8, 2016: Cell Research
Rong-Fu Wang
No abstract text is available yet for this article.
January 2017: Cell Research
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