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Cell Research

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https://www.readbyqxmd.com/read/30006613/mettl3-mettl14-methyltransferase-complex-regulates-the-quiescence-of-adult-hematopoietic-stem-cells
#1
LETTER
Qi Jason Yao, Lina Sang, Minghui Lin, Xiujuan Yin, Wenjie Dong, Yuping Gong, Bo O Zhou
No abstract text is available yet for this article.
July 13, 2018: Cell Research
https://www.readbyqxmd.com/read/29980733/competing-for-enhancers-pvt1-fine-tunes-myc-expression
#2
Abhijit Parolia, Marcin Cieślik, Arul M Chinnaiyan
No abstract text is available yet for this article.
July 6, 2018: Cell Research
https://www.readbyqxmd.com/read/29976953/threshold-for-neural-tube-defect-risk-by-accumulated-singleton-loss-of-function-variants
#3
LETTER
Zhongzhong Chen, Yunping Lei, Yufang Zheng, Vanessa Aguiar-Pulido, M Elizabeth Ross, Rui Peng, Li Jin, Ting Zhang, Richard H Finnell, Hongyan Wang
No abstract text is available yet for this article.
July 5, 2018: Cell Research
https://www.readbyqxmd.com/read/29959401/exosomal-pd-l1-harbors-active-defense-function-to-suppress-t-cell-killing-of-breast-cancer-cells-and-promote-tumor-growth
#4
LETTER
Yi Yang, Chia-Wei Li, Li-Chuan Chan, Yongkun Wei, Jung-Mao Hsu, Weiya Xia, Jong-Ho Cha, Junwei Hou, Jennifer L Hsu, Linlin Sun, Mien-Chie Hung
No abstract text is available yet for this article.
June 29, 2018: Cell Research
https://www.readbyqxmd.com/read/29959400/author-correction-embryonic-senescent-cells-re-enter-cell-cycle-and-contribute-to-tissues-after-birth
#5
Yi Li, Huan Zhao, Xiuzhen Huang, Juan Tang, Shaohua Zhang, Yan Li, Xiuxiu Liu, Lingjuan He, Zhenyu Ju, Kathy O Lui, Bin Zhou
The authors apologized for the spelling mistake of author name for Zhengyu Ju. The correct form is Zhenyu Ju. We apologize for any hassle that may have been caused by our mistake.
June 29, 2018: Cell Research
https://www.readbyqxmd.com/read/29941926/necroptosis-of-tumor-cells-leads-to-tumor-necrosis-and-promotes-tumor-metastasis
#6
LETTER
Delong Jiao, Zhenyu Cai, Swati Choksi, Dan Ma, Moran Choe, Hyung-Joon Kwon, Jin Young Baik, Brian G Rowan, Chengyu Liu, Zheng-Gang Liu
No abstract text is available yet for this article.
June 25, 2018: Cell Research
https://www.readbyqxmd.com/read/29934617/glutaminase-gls1-senses-glutamine-availability-in-a-non-enzymatic-manner-triggering-mitochondrial-fusion
#7
LETTER
Wei-Feng Cai, Cixiong Zhang, Yu-Qing Wu, Gui Zhuang, Zhiyun Ye, Chen-Song Zhang, Sheng-Cai Lin
No abstract text is available yet for this article.
June 22, 2018: Cell Research
https://www.readbyqxmd.com/read/29934616/pten-l-is-a-novel-protein-phosphatase-for-ubiquitin-dephosphorylation-to-inhibit-pink1-parkin-mediated-mitophagy
#8
Liming Wang, Yik-Lam Cho, Yancheng Tang, Jigang Wang, Jung-Eun Park, Yajun Wu, Chunxin Wang, Yan Tong, Ritu Chawla, Jianbin Zhang, Yin Shi, Shuo Deng, Guang Lu, Yihua Wu, Hayden Weng-Siong Tan, Pornteera Pawijit, Grace Gui-Yin Lim, Hui-Ying Chan, Jingzi Zhang, Lei Fang, Hanry Yu, Yih-Cherng Liou, Mallilankaraman Karthik, Boon-Huat Bay, Kah-Leong Lim, Siu-Kwan Sze, Celestial T Yap, Han-Ming Shen
Mitophagy is an important type of selective autophagy for specific elimination of damaged mitochondria. PTEN-induced putative kinase protein 1 (PINK1)-catalyzed phosphorylation of ubiquitin (Ub) plays a critical role in the onset of PINK1-Parkin-mediated mitophagy. Phosphatase and tensin homolog (PTEN)-long (PTEN-L) is a newly identified isoform of PTEN, with addition of 173 amino acids to its N-terminus. Here we report that PTEN-L is a novel negative regulator of mitophagy via its protein phosphatase activity against phosphorylated ubiquitin...
June 22, 2018: Cell Research
https://www.readbyqxmd.com/read/29921919/author-correction-immp2l-a-mitochondrial-protease-suppressing-cellular-senescence
#9
Valentina Sica, Guido Kroemer
We apologize for an error we just found in the paper published online on 29 May 2018. The protein SERPINB4 is mistakenly indicated as SERPIN4B for three times in the main text and once in Fig. 1. The corrected sentences and Fig. 1 are provided below.   This paragraph is the same with the one below. Is it redundant? The pdf file is correct.
June 19, 2018: Cell Research
https://www.readbyqxmd.com/read/29875397/protac-induced-btk-degradation-as-a-novel-therapy-for-mutated-btk-c481s-induced-ibrutinib-resistant-b-cell-malignancies
#10
LETTER
Yonghui Sun, Xingwang Zhao, Ning Ding, Hongying Gao, Yue Wu, Yiqing Yang, Meng Zhao, Jinseok Hwang, Yuqin Song, Wanli Liu, Yu Rao
No abstract text is available yet for this article.
June 6, 2018: Cell Research
https://www.readbyqxmd.com/read/29875396/be-plus-a-new-base-editing-tool-with-broadened-editing-window-and-enhanced-fidelity
#11
Wen Jiang, Songjie Feng, Shisheng Huang, Wenxia Yu, Guanglei Li, Guang Yang, Yajing Liu, Yu Zhang, Lei Zhang, Yu Hou, Jia Chen, Jieping Chen, Xingxu Huang
Base editor (BE), containing a cytidine deaminase and catalytically defective Cas9, has been widely used to perform base editing. However, the narrow editing window of BE limits its utility. Here, we developed a new editing technology named as base editor for programming larger C to U (T) scope (BE-PLUS) by fusing 10 copies of GCN4 peptide to nCas9(D10A) for recruiting scFv-APOBEC-UGI-GB1 to the target sites. The new system achieves base editing with a broadened window, resulting in an increased genome-targeting scope...
June 6, 2018: Cell Research
https://www.readbyqxmd.com/read/29875395/ribophagy-new-receptor-discovered
#12
Donna Denton, Sharad Kumar
No abstract text is available yet for this article.
June 6, 2018: Cell Research
https://www.readbyqxmd.com/read/29872106/embryonic-senescent-cells-re-enter-cell-cycle-and-contribute-to-tissues-after-birth
#13
LETTER
Yi Li, Huan Zhao, Xiuzhen Huang, Juan Tang, Shaohua Zhang, Yan Li, Xiuxiu Liu, Lingjuan He, Zhengyu Ju, Kathy O Lui, Bin Zhou
No abstract text is available yet for this article.
June 5, 2018: Cell Research
https://www.readbyqxmd.com/read/29844583/tissue-clearing-of-both-hard-and-soft-tissue-organs-with-the-pegasos-method
#14
Dian Jing, Shiwen Zhang, Wenjing Luo, Xiaofei Gao, Yi Men, Chi Ma, Xiaohua Liu, Yating Yi, Abhijit Bugde, Bo O Zhou, Zhihe Zhao, Quan Yuan, Jian Q Feng, Liang Gao, Woo-Ping Ge, Hu Zhao
Tissue clearing technique enables visualization of opaque organs and tissues in 3-dimensions (3-D) by turning tissue transparent. Current tissue clearing methods are restricted by limited types of tissues that can be cleared with each individual protocol, which inevitably led to the presence of blind-spots within whole body or body parts imaging. Hard tissues including bones and teeth are still the most difficult organs to be cleared. In addition, loss of endogenous fluorescence remains a major concern for solvent-based clearing methods...
May 29, 2018: Cell Research
https://www.readbyqxmd.com/read/29728688/the-genomic-landscape-of-small-cell-carcinoma-of-the-esophagus
#15
LETTER
Feng Wang, Dong-Bing Liu, Qi Zhao, Gang Chen, Xin-Ming Liu, Ying-Nan Wang, Hong Su, Yan-Ru Qin, Yi-Fu He, Qing-Feng Zou, Yan-Hui Liu, You-En Lin, Ze-Xian Liu, Jin-Xin Bei, Rui-Hua Xu
No abstract text is available yet for this article.
May 4, 2018: Cell Research
https://www.readbyqxmd.com/read/29700422/structure-of-the-receptor-activated-human-trpc6-and-trpc3-ion-channels
#16
Qinglin Tang, Wenjun Guo, Li Zheng, Jing-Xiang Wu, Meng Liu, Xindi Zhou, Xiaolin Zhang, Lei Chen
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the family of canonical transient receptor potential (TRPC) channels. They are activated by diacylglycerol, a lipid second messenger. TRPC6 and TRPC3 are involved in many physiological processes and implicated in human genetic diseases. Here we present the structure of human TRPC6 homotetramer in complex with a newly identified high-affinity inhibitor BTDM solved by single-particle cryo-electron microscopy to 3.8 Å resolution...
April 26, 2018: Cell Research
https://www.readbyqxmd.com/read/29867213/spatial-transcriptomic-survey-of-human-embryonic-cerebral-cortex-by-single-cell-rna-seq-analysis
#17
Xiaoying Fan, Ji Dong, Suijuan Zhong, Yuan Wei, Qian Wu, Liying Yan, Jun Yong, Le Sun, Xiaoye Wang, Yangyu Zhao, Wei Wang, Jie Yan, Xiaoqun Wang, Jie Qiao, Fuchou Tang
The cellular complexity of human brain development has been intensively investigated, although a regional characterization of the entire human cerebral cortex based on single-cell transcriptome analysis has not been reported. Here, we performed RNA-seq on over 4,000 individual cells from 22 brain regions of human mid-gestation embryos. We identified 29 cell sub-clusters, which showed different proportions in each region and the pons showed especially high percentage of astrocytes. Embryonic neurons were not as diverse as adult neurons, although they possessed important features of their destinies in adults...
July 2018: Cell Research
https://www.readbyqxmd.com/read/29844582/plant-g-protein-activation-connecting-to-plant-receptor-kinases
#18
Kyle W Bender, Cyril Zipfel
No abstract text is available yet for this article.
July 2018: Cell Research
https://www.readbyqxmd.com/read/29844578/destabilization-of-linker-histone-h1-2-is-essential-for-atm-activation-and-dna-damage-repair
#19
Zhiming Li, Yinglu Li, Ming Tang, Bin Peng, Xiaopeng Lu, Qiaoyan Yang, Qian Zhu, Tianyun Hou, Meiting Li, Chaohua Liu, Lina Wang, Xingzhi Xu, Ying Zhao, Haiying Wang, Yang Yang, Wei-Guo Zhu
Linker histone H1 is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair is unclear. Here, we report that linker histone H1.2 is an essential regulator of ataxia telangiectasia mutated (ATM) activation. We show that H1.2 protects chromatin from aberrant ATM activation through direct interaction with the ATM HEAT repeat domain and inhibition of MRE11-RAD50-NBS1 (MRN) complex-dependent ATM recruitment. Upon DNA damage, H1.2 undergoes rapid PARP1-dependent chromatin dissociation through poly-ADP-ribosylation (PARylation) of its C terminus and further proteasomal degradation...
July 2018: Cell Research
https://www.readbyqxmd.com/read/29795446/the-bh3-only-protein-bad-mediates-tnf%C3%AE-cytotoxicity-despite-concurrent-activation-of-ikk-and-nf-%C3%AE%C2%BAb-in-septic-shock
#20
Jie Yan, Hao Zhang, Jialing Xiang, Yu Zhao, Xiang Yuan, Beicheng Sun, Anning Lin
The inflammatory cytokine TNFα plays a crucial role in the pathology of many inflammatory and infectious diseases. However, the mechanism underlying TNFα cytotoxicity in these diseases is incompletely understood. Here we report that the pro-apoptotic BCL-2 family member BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in vitro by inducing apoptosis in cultured cells and in vivo by eliciting tissue damage of multiple organs and contributing to mortality in septic shock. At high doses, TNFα significantly inactivates RhoA through activation of the Src-p190GAP pathway, resulting in massive actin stress fiber destabilization, followed by substantial BAD release from the cytoskeleton to the cytosol...
July 2018: Cell Research
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