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Cell Research

Fan Yu, Song Guo, Te Li, Jie Ran, Wei Zhao, Dengwen Li, Min Liu, Xiumin Yan, Xiaoyong Yang, Xueliang Zhu, Jun Zhou
No abstract text is available yet for this article.
November 14, 2018: Cell Research
Shuai Zhao, Lingling Cheng, Yifei Gao, Baichao Zhang, Xiangdong Zheng, Liang Wang, Pilong Li, Qianwen Sun, Haitao Li
Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide with H3K27me3, and is the functional homolog of Polycomb protein. This raises the question whether genuine HP1 homologs exist in plants. Here, we report on the discovery of ADCP1, a plant-specific triple tandem Agenet protein, as a multivalent H3K9me reader in Arabidopsis, and establish that ADCP1 is essential for heterochromatin formation and transposon silencing through modulating H3K9 and DNA methylation levels...
November 13, 2018: Cell Research
Bo Zhang, Weiwei Ye, Yangmiao Ye, Huan Zhou, Abdullah F U H Saeed, Jing Chen, Jinying Lin, Vanja Perčulija, Qi Chen, Chun-Jung Chen, Ming-Xian Chang, Muhammad Iqbal Choudhary, Songying Ouyang
No abstract text is available yet for this article.
November 13, 2018: Cell Research
Tianzi Liuyu, Keying Yu, Liya Ye, Zhidong Zhang, Man Zhang, Yujie Ren, Zeng Cai, Qiyun Zhu, Dandan Lin, Bo Zhong
The activity and stability of the adapter protein MAVS (also known as VISA, Cardif and IPS-1), which critically mediates cellular antiviral responses, are extensively regulated by ubiquitination. However, the process whereby MAVS is deubiquitinated is unclear. Here, we report that the ovarian tumor family deubiquitinase 4 (OTUD4) targets MAVS for deubiquitination. Viral infection leads to the IRF3/7-dependent upregulation of OTUD4 which interacts with MAVS to remove K48-linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling...
November 8, 2018: Cell Research
Chaoyou Xue, Eric C Greene
No abstract text is available yet for this article.
October 26, 2018: Cell Research
Gong-Bo Fu, Wei-Jian Huang, Min Zeng, Xu Zhou, Hong-Ping Wu, Chang-Cheng Liu, Han Wu, Jun Weng, Hong-Dan Zhang, Yong-Chao Cai, Charles Ashton, Min Ding, Dan Tang, Bao-Hua Zhang, Yi Gao, Wei-Feng Yu, Bo Zhai, Zhi-Ying He, Hong-Yang Wang, He-Xin Yan
The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be converted to liver progenitor-like cells in vitro with defined chemical factors. Here we describe a protocol achieving efficient conversion of human primary hepatocytes into liver progenitor-like cells (HepLPCs) through delivery of developmentally relevant cues, including NAD +  -dependent deacetylase SIRT1 signaling...
October 25, 2018: Cell Research
Jingtao Guo, Edward J Grow, Hana Mlcochova, Geoffrey J Maher, Cecilia Lindskog, Xichen Nie, Yixuan Guo, Yodai Takei, Jina Yun, Long Cai, Robin Kim, Douglas T Carrell, Anne Goriely, James M Hotaling, Bradley R Cairns
Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility and faithful genome propagation. Here, we performed single-cell RNA sequencing of ~6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig, myoid, Sertoli, endothelial, macrophage), and observed germline-niche interactions and key human-mouse differences. Spermatogenesis, including meiosis, was reconstructed computationally, revealing sequential coding, non-coding, and repeat-element transcriptional signatures...
October 12, 2018: Cell Research
Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei, Yigong Shi
The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B complex) and followed by the activated spliceosome (Bact complex). The pre-B-to-B and B-to-Bact transitions are driven by the ATPase/helicases Prp28 and Brr2, respectively. In this study, we report the cryo-electron microscopy structures of the human pre-B complex and the human B complex at an average resolution of 5.7 and 3.8 Å, respectively. In the pre-B complex, U1 and U2 small nuclear ribonucleoproteins (snRNPs) associate with two edges of the tetrahedron-shaped U4/U6...
October 12, 2018: Cell Research
Yansong Xue, Si Ming Man
No abstract text is available yet for this article.
October 8, 2018: Cell Research
Bo Zhou, Jia-Yuan Zhang, Xian-Shuo Liu, Hang-Zi Chen, Yuan-Li Ai, Kang Cheng, Ru-Yue Sun, Dawang Zhou, Jiahuai Han, Qiao Wu
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death, such as ferroptosis, apoptosis and necroptosis. However, whether iron-elevated ROS is also linked to pyroptosis has not been reported. Here, we demonstrate that iron-activated ROS can induce pyroptosis via a Tom20-Bax-caspase-GSDME pathway. In melanoma cells, iron enhanced ROS signaling initiated by CCCP, causing the oxidation and oligomerization of the mitochondrial outer membrane protein Tom20...
October 4, 2018: Cell Research
Yiwei Wang, Yuxuan Jiang, Shan Ding, Jiawang Li, Ningjing Song, Yujing Ren, Danning Hong, Cai Wu, Bin Li, Feng Wang, Wei He, Jiawei Wang, Ziqing Mei
The ubiquitin system is important for drug discovery, and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions, previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs, resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However, the molecular mechanism for this selectivity was elusive...
September 25, 2018: Cell Research
Editorial Office
No abstract text is available yet for this article.
November 2018: Cell Research
Bin Zhao, Wenqi Xu, Bowen Rong, Guoyu Chen, Xuanjia Ye, Ruofei Dai, Wenjing Li, Jiajia Chen, Jiajun Cai, Lei Song, Zhao-Qing Luo, Rong Zeng, Yang Shi, Jing-Dong J Han, Fei Lan
No abstract text is available yet for this article.
November 2018: Cell Research
Yangyang Feng, Yuan Tian, Zihan Wu, Yanhui Xu
No abstract text is available yet for this article.
November 2018: Cell Research
Yu-Chieh David Chen, Anupama Dahanukar
No abstract text is available yet for this article.
November 2018: Cell Research
Jingyi Li, Shijun Shen, Jiayu Chen, Wenqiang Liu, Xiaocui Li, Qianshu Zhu, Beiying Wang, Xiaolong Chen, Li Wu, Mingzhu Wang, Liang Gu, Hong Wang, Jiqing Yin, Cizhong Jiang, Shaorong Gao
Extensive and accurate chromatin remodeling is essential during primordial germ cell (PGC) development for the perpetuation of genetic information across generations. Here, we report that distal cis-regulatory elements (CREs) marked by DNase I-hypersensitive sites (DHSs) show temporally restricted activities during mouse and human PGC development. Using DHS maps as proxy, we accurately locate the genome-wide binding sites of pluripotency transcription factors in mouse PGCs. Unexpectedly, we found that mouse female meiotic recombination hotspots can be captured by DHSs, and for the first time, we identified 12,211 recombination hotspots in mouse female PGCs...
November 2018: Cell Research
Yuxin Wang, George R Stark
No abstract text is available yet for this article.
November 2018: Cell Research
Fei Yan, Aref Al-Kali, Zijie Zhang, Jun Liu, Jiuxia Pang, Na Zhao, Chuan He, Mark R Litzow, Shujun Liu
N6 -methyladenosine (m6 A) on mRNAs is critical for various biological processes, yet whether m6 A regulates drug resistance remains unknown. Here we show that developing resistant phenotypes during tyrosine kinase inhibitor (TKI) therapy depends on m6 A reduction resulting from FTO overexpression in leukemia cells. This deregulated FTO-m6 A axis pre-exists in naïve cell populations that are genetically homogeneous and is inducible/reversible in response to TKI treatment. Cells with mRNA m6 A hypomethylation and FTO upregulation demonstrate more TKI tolerance and higher growth rates in mice...
November 2018: Cell Research
Zeyu Zhang, Meng Wang, Dongfang Xie, Zenghui Huang, Lisha Zhang, Ying Yang, Dongxue Ma, Wenguang Li, Qi Zhou, Yun-Gui Yang, Xiu-Jie Wang
The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6 -methyladenosine (m6 A) methyltransferase, through promoting the translation of neuronal early-response genes. Such effect is exquisitely dependent on the m6 A methyltransferase function of METTL3. Depleting METTL3 in mouse hippocampus reduces memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m6 A methyltransferase function of METTL3 was restored...
November 2018: Cell Research
Chao Wang, Jiahuan Chen, Qianfei Zhang, Wang Li, Shengbo Zhang, Yanjie Xu, Fang Wang, Bing Zhang, Yan Zhang, Wei-Qiang Gao
Androgen deprivation therapy (ADT) is a main treatment for prostate cancer (PCa) but the disease often recurs and becomes castration-resistant in nearly all patients. Recent data implicate the involvement of immune cells in the development of this castration-resistant prostate cancer (CRPC). In particular, T cells have been found to be expanded in both PCa patients and mouse models shortly after androgen deprivation. However, whether or which of the T cell subtypes play an important role during the development of CRPC is unknown...
November 2018: Cell Research
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