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Journal de Mycologie Médicale

T-A Vyzantiadis, E Yannaki, D A Oliver, A-M Markantonatou, Z Boussiou, A Louka, E Zachrou, E M Johnson
OBJECTIVE: The intention of the study was to assess whether a unique daily specimen is adequate for prophylactic posaconazole TDM in haematology patients and if bioassay and HPLC produce similar results and could be equally used in clinical setting. METHOD: Serum specimens from thirty haematology patients were collected at the end of the first and second week of treatment, just before the morning dose, 2 and 6 to 8hours afterwards. Levels were measured by bioassay in 157 specimens and additionally by HPLC in 51 of them...
January 6, 2018: Journal de Mycologie Médicale
H Moallaei, M J Namazi, J P Bouchara, S Pourhammed
BACKGROUND: Malassezia species, usually part of normal human skin microbiota, may also cause cutaneous infections, mainly pityriasis versicolor (PV) which may rapidly spread in crowded communities, particularly in students' dormitories and sport leisure centers. OBJECTIVE: Few studies have been conducted on PV in students in the Middle East. The present study was designed to determine prevalence of Malassezia species and related diseases in students from city of Sabzevar, Northeast Iran...
January 5, 2018: Journal de Mycologie Médicale
A Makarasen, N Reukngam, P Khlaychan, P Chuysinuan, M Isobe, S Techasakul
Both valinomycin and cereulide are cyclic depsipeptides and are known K+ ion-selective ionophores. Valinomycin and cereulide feature low minimum inhibitory concentration (MIC) values against Candida albicans and Cryptococcus albidus. This study aims at investigating the mode of action and verifying the efficacy of valinomycin or cereulide alone and in combination with amphotericin B (AmB) in vitro against both microorganisms. Based on the results from membrane permeability and fluidity assays for detection of plasma membrane permeabilization and membrane dynamics, the present study demonstrated that valinomycin and cereulide exhibit antifungal activity against C...
December 21, 2017: Journal de Mycologie Médicale
E Gonçalves Silva, S Marilia de Souza Silva, C Rodrigues Paula, L da Silva Ruiz, A Latercia Tranches Dias
Cryptococcosis is a subacute or chronic disease. For many years, amphotericin B has been used in severe fungal infections. Voriconazole is a triazole with high bioavailability, a large distribution volume, and excellent penetration of the central nervous system (CNS). The objective of this study was to evaluate the production of pro-inflammatory cytokines in the lungs during an experimental infection caused by C. neoformans in murine model (SCID) that was treated with amphotericin B and voriconazole. After intravenous inoculation with 3...
December 19, 2017: Journal de Mycologie Médicale
Y Liu, M Kang, H Ye, Z Zong, X Lv
OBJECTIVE OF THE STUDY: Candida parapsilosis has emerged as an important cause of bloodstream infections (BSI) in the health care setting. We aimed to describe the clinical characteristics and drug resistance of C. parapsilosis BSI in West China Hospital of Sichuan University in China and provide the basis for prevention and treatment of this disease. PATIENTS: We retrospectively collected and analyzed patients presented in our hospital reported with C. parapsilosis BSI from January 2012 to January 2015...
December 15, 2017: Journal de Mycologie Médicale
G Morán, B Uberti, A Ortloff, H Folch
Neutrophils are the predominant inflammatory cells that infiltrate airways during acute exacerbation of asthma. The importance of A. fumigatus sensitization, and IgE response in the airways in patients with acute asthma is unclear. Rockefeller (RK) mice were sensitized with A. fumigatus extract protein. The animals were subsequently challenged with different degrees of A. fumigatus contamination in the cage bedding. All groups of mice were euthanized to obtain bronchoalveolar lavage fluid (BALF) for cytological and Elisa assays, and lung tissue for histological analysis...
December 7, 2017: Journal de Mycologie Médicale
S K Swain, I C Behera, M C Sahu, A Das
INTRODUCTION: Otomycosis is a common clinical condition seen in outpatient department of otorhinolaryngology. The treatment of the otomycosis is also very simple. However, sometime it is difficult to treat otomycosis along with mastoid cavity, chronic suppurative otitis media, immunocompromised patient, etc. with conventional treatment, called recalcitrant otomycosis. Here, we describe a technique of treatment for recalcitrant otomycosis. MATERIALS AND METHODS: This is a prospective observational study/clinical trial carried out on 44 patients of recalcitrant otomycosis...
December 6, 2017: Journal de Mycologie Médicale
J A da Rocha Curvelo, L F Reis de Sá, D C Clemente de Moraes, R M Soares, A Ferreira-Pereira
BACKGROUND: Candidiasis is a major opportunistic fungal infection in humans. The low number of antifungal drugs available to treat Candida infections and the increasing incidence of multidrug resistant (MDR) strains point to an urgent need of identifying new therapeutic options. The role of salivary components can provide insights for the development of new methodologies of control. OBJECTIVE: The aim of this study was to evaluate the ability of histatin-5, a constitutive immunological peptide present in saliva, in reversing fungal MDR phenotype, using a resistant Saccharomyces cerevisiae strain as model of study...
December 4, 2017: Journal de Mycologie Médicale
S Taghipour, N Kiasat, S Shafiei, M Halvaeezadeh, A Rezaei-Matehkolaei, A Zarei Mahmoudabadi
OBJECTIVE: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials...
November 29, 2017: Journal de Mycologie Médicale
N Khebizi, H Boudjella, C Bijani, N Bouras, H-P Klenk, F Pont, F Mathieu, N Sabaou
An actinobacterial strain, HG29, with potent activity against pathogenic, toxigenic and phytopathogenic fungi was isolated from a Saharan soil sample of Algeria. On the basis of morphological and chemotaxonomic characteristics, the strain was classified in the genus Streptomyces. Analysis of the 16S rRNA gene sequence showed a similarity level of 99.3% with Streptomyces gancidicus NBRC 15412(T). The comparison of its cultural and physiological characteristics with this species revealed significant differences...
November 17, 2017: Journal de Mycologie Médicale
K Diongue, M A Diallo, M Ndiaye, M C Seck, A S Badiane, D Ndiaye
INTRODUCTION: Fungal interdigital tinea pedis (ITP) is a common pathology mainly due to dermatophytes and yeasts. Fusarium sp. is rarely incriminated in the genesis of intertrigo. In Dakar, a recent study conducted in 2016 on fungal ITP showed that Fusarium were more involved in the etiology of ITP than dermatophytes, coming just after yeasts dominated by Candida. Following this, we wanted to draw attention to the increasing incidence of ITP resulting from Fusarium spp., in Dakar, Senegal, and to analyze the epidemiological and mycological particularities of these ITP due to Fusarium spp...
November 10, 2017: Journal de Mycologie Médicale
I Kara, F Yıldırım, Ö Özgen, S Erganiş, M Aydoğdu, M Dizbay, G Gürsel, A Kalkanci
Saccharomyces cerevisiae is a common colonizer of the human gastrointestinal system as a benign organism. Enteral supplementation of this yeast as a probiotic product is effective in the treatment of antibiotic associated diarrhae. In rare occasions it can cause invasive infections. We present two fungemia cases in an intensive care unit following probiotic treatment containing S. boulardii. We are warning the safety of probiotic treatment in critically ill patients.
November 10, 2017: Journal de Mycologie Médicale
J-R Zahar, S Jolivet, H Adam, C Dananché, J Lizon, S Alfandari, H Boulestreau, N Baghdadi, J-O Bay, A-M Bénéteau, M-E Bougnoux, M-P Brenier-Pinchart, J-H Dalle, S Fournier, J-G Fuzibet, C Kauffmann-Lacroix, I Le Guinche, D Lepelletier, N Loukili, A Lory, M Morvan, R Oumedaly, P Ribaud, P Rohrlich, P Vanhems, S Aho, D Vanjak, J-P Gangneux
The increase use of immunosuppressive treatments in patients with solid cancer and/or inflammatory diseases requires revisiting our practices for the prevention of infectious risk in the care setting. A review of the literature by a multidisciplinary working group at the beginning of 2014 wished to answer the following 4 questions to improve healthcare immunocompromised patients: (I) How can we define immunocompromised patients with high, intermediate and low infectious risk, (II) which air treatment should be recommended for this specific population? (III) What additional precautions should be recommended for immunocompromised patients at risk for infection? (IV) Which global environmental control should be recommended? Based on data from the literature and using the GRADE method, we propose 15 recommendations that could help to reduce the risk of infection in these exposed populations...
November 10, 2017: Journal de Mycologie Médicale
S Chadli, M Aghrouch, N Taqarort, M Malmoussi, Z Ouagari, F Moustaoui, M Bourouache, S Oulkheir
INTRODUCTION: Neuromeningeal cryptococcosis (NMC) is a severe and fatal opportunistic infection. Lethality is frequent in the absence of treatment, especially in the presence of HIV co-infection. OBJECTIVE: To determine the prevalence, epidemiological, clinical, biological and therapeutic aspects as well as the evolution of NMC for patients infected with HIV. PATIENTS AND METHODS: This is a retrospective study of 40 cases of neuromeningeal cryptococcosis diagnosed in HIV-infected patients...
November 10, 2017: Journal de Mycologie Médicale
K E Angora, A Ira-Bonouman, A H Vanga-Bosson, A Konaté, F K Kassi, K Tuo, K Sylla-Thanon, P C Kiki-Barro, S Miezan, A V Bedia-Tanoh, V Djohan, W Yavo, E H Menan, A T Offianan
OBJECTIVE: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire. PATIENTS AND METHODS: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded. RESULTS: In this study, 1898 patient files were selected...
November 7, 2017: Journal de Mycologie Médicale
A Seghir, Z Boucherit-Otmani, K Boucherit, L Sari-Belkharroubi
Yeasts can adhere to medical implants and cause infections responsible for high morbidity and mortality among hospitalized patients. The objective of this study is to investigate the infectivity on peripheral vascular catheters collected from general surgery and cardiology in University Hospital of Tlemcen. The results showed that from 29 samples altered by yeast, 35 Candida sp. strains were isolated. However, Candida albicans is the most isolated species in an infectious context. Risk factors that accompanied the infections are the duration of implantation, male gender, and bacterial presence...
November 6, 2017: Journal de Mycologie Médicale
Y Cheng, Y Gao, X Y Liu, G Y Wang, G Q Zhang, S Q Gao
Mucormycosis is a rare life-threatening opportunistic infection caused by fungi of the order Mucorales. We report a case of rhinocerebral mucormycosis caused by Rhizopus arrhizus var. tonkinensis, the first formally reported case in the literature. Early diagnosis, reversal of predisposing factors, surgical debridement and prompt administration of antifungal therapy are critical for good outcome.
November 6, 2017: Journal de Mycologie Médicale
S Agha Kuchak Afshari, H Rahimi, S J Hashemi, R Daie Ghazvini, H Badali, S Aghaei Gharehbolagh, S Rezaie
BACKGROUND: In immunocompromised patients suffering from invasive fungal infections, rapid identification of fungal species is important since the appropriate treatment is usually related to the responsible species. We describe here, an assay based on combination of PCR and reverse line blot hybridization (PCR/RLB) for differentiation causative agent of fungal infections. MATERIALS AND METHODS: We performed PCR/RLB assay on 10 reference strains, which include Aspergillus species (A...
October 31, 2017: Journal de Mycologie Médicale
H Trablesi, I Hadrich, S Neji, N Fendri, D Ghorbel, F Makni, H Ayadi, S Kammoun, A Ayadi
The aim of the present study was to investigate the epidemiological and fungal environmental profile in asthmatic patients. We conducted a prospective study involving 49 patients with allergic asthma. One hundred and forty-five clinical samples and 289 environmental samples were performed. Only 30 patients accepted to participate to the environmental study at their home. For specific IgE antibodies, ELISA assay was conducted for 21 patients. Molecular ITS sequencing was performed for 37 isolates. The frequency of attacks was significantly associated with the seasonality, which was closely related to climate (P=0...
October 25, 2017: Journal de Mycologie Médicale
S Zayet, I Chaabane, B Kilani, M Bouaziz, F Ladeb, H B Tiouiri
Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involvement in a 27 years-old male patient, followed for S-β-thalassemia and with a history of candidemia. The fungus was isolated from a needle biopsy of the vertebral disk. The outcome was favorable under antifungal treatment by amphotericin B and voriconazole...
October 25, 2017: Journal de Mycologie Médicale
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