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Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti

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https://www.readbyqxmd.com/read/29708359/diagnostic-prognostic-and-predictive-immunohistochemistry-in-malignant-melanoma-of-the-skin
#1
Roncati Luca
No abstract text is available yet for this article.
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708358/cutaneous-and-subcutaneous-metastases-of-adenocarcinoma-as-a-dominant-clinical-manifestation-of-malignancy-of-unknown-origin-a-case-report
#2
Vladimír Bartoš, Kamila Hamarová
BACKGROUND: Cutaneous metastases occur in 0.6-10.4% of all patients with underlying malignancy. Among them, the site of origin remains unknown in 4.4-14.5% of all cases. CASE: The authors describe a 68-year-old man with widespread skin and soft tissue metastases appearing as the first and dominant clinical manifestation of oncologic disease. Physical examination and CT scans revealed multiple cutaneous and subcutaneous tumor nodules arising in the neck, chest, abdomen, lumbar region and right forearm, as well as in the gluteal and iliacus muscles and in the proximal part of the left thigh...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708357/recent-trends-in-survival-of-testicular-cancer-patients-nation-wide-population-based-study
#3
Dalibor Ondrus, Martina Ondrusova, Martin Suchansky
INTRODUCTION AND AIM: Survival of germ cell testicular cancer (TC) patients is better than for other malignancies and has not yet been exactly studied in the Slovak Republic. The aim of the study, based on the analyses of epidemiological data over time, was to present 5-year survival trends for germ cell TC patients. PATIENTS AND METHODS: Survival is assessed within the framework of a nation-wide retroprospective study among TC patients newly diagnosed between 1993-2007 (divided to three 5-year periods according the time of diagnosis - 1993-1997, 1998-2002 and 2003-2007)...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708356/mapk-erk-signal-pathway-alterations-in-patients-with-langerhans-cell-histiocytosis
#4
Olga Novosad, Tanya Skrypets, Yan Pastushenko, Iryna Titorenko, Arina Martynchyk, Oksana Skachkova, Mariia Inomistova, Alex Gorbach, Nataliia Khranovska, Irina Kryachok
BACKGROUND: Clinical outcomes of Langerhans cell histiocytosis (LCH) are highly variable. It has been suggested that mitogen-activated protein kinase (MAPK) /extracellular signal-regulated kinases (ERK) signaling pathway might be activated in LCH patients. MATERIALS AND METHODS: We investigated KRAS, BRAF and NRAS mutations in patients with LCH by qPCR. RESULTS: Eight adult patients with LCH were treated at the National Cancer Institute, Kiev, Ukraine...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708355/-quality-of-life-after-high-dose-brachytherapy-in-patients-with-early-oral-carcinoma
#5
Helena Doležalová, Nicole Blechová, Jiří Petera
BACKGROUND: The prevalence of head and neck tumors has continually increased over the past decades, which is a serious medical and social problem. This study retrospectively assessed the quality of life of patients with early-stage oral cavity tumors after high-dose rate (HDR) brachytherapy. MATERIAL AND METHODS: Quality of life was evaluated in 14 patients with early-onset oral cavity tumors who underwent HDR brachytherapy at the Department of Oncology and Radiotherapy, University Hospital Hradec Kralove...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708354/-new-approaches-for-chemosensitivity-testing-in-malignant-diseases
#6
Lucia Sommerová, Eva Michalová, Roman Hrstka
BACKGROUND: Due to the irreplaceable role of chemotherapy in cancer treatment, research has focused on improving the efficacies of individual drugs and minimizing, or completely suppressing, their negative side effects. Based on long-term experience and the results of clinical trials, the selection of appropriate treatment is currently based on classical clinical diagnostic criteria, such as tumor size, grade, and the presence or absence of standard markers. However, complications arise due to variability between patients and tumor heterogeneity...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708353/-treatment-of-metastatic-renal-cell-carcinoma
#7
Igor Richter, Josef Dvořák
INTRODUCTION: Renal cell cancer accounts for approximately 2-3% of all cases of malignancy. The incidence of kidney cancer in the Czech Republic is the highest in the world. Approximately 70% of renal cell carcinomas are clear-cell renal cancer. Various treatment options for metastatic renal cell cancer (mRCC) have been developed. Treatment regimens comprise antiangiogenic drugs in combination with vascular endothelial growth factor receptor inhibitors, mTOR inhibitors, and immunotherapy...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708352/-anogenital-hpv-infection-as-the-potential-risk-factor-for-oropharyngeal-carcinoma
#8
Borek Sehnal, Tomáš Podlešák, Emanuela Kmoníčková, Monika Nipčová, Daniel Driák, Jiří Sláma, Michal Zikán
BACKGROUND: Human papillomavirus (HPV) can cause cervical, other genital, anal, head, and neck cancers. The incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer most commonly caused by HPV infection, is increasing. The prevalence of oral HPV infections is considerably lower than that of genital HPV infections; however, infection of both sites is strongly associated with sexual behavior. Although the natural histories of cervical and oral HPV infections do not markedly differ, the virus seems to rarely infect oral and genital sites simultaneously...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708351/long-non-coding-rnas-as-regulators-of-the-mitogen-activated-protein-kinase-mapk-pathway-in-cancer
#9
Behnoosh Tasharrofi, Soudeh Ghafouri-Fard
BACKGROUND: The mitogen-activated protein kinase (MAPK) pathway contributes to regulation of many cellular functions, such as cell proliferation and differentiation, mobility and apoptosis. Extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK) /p38 and ERK5 construct the three main modules in this pathway. The Raf-ERK1/2 and JNK cascades contribute in cell proliferation, migration, and survival and are principal regulators of malignant phenotype. This pathway is itself regulated by several outside signals as well as lateral signals from other pathways, which construct a complex network...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29708350/-human-papillomavirus-role-in-cervical-carcinogenesis-and-methods-of-detection
#10
Martin Bartošík, Roman Hrstka, Ludmila Jiráková
BACKGROUND: Persistent infection with high-risk human papillomavirus (HPV) strains, especially HPV 16 and HPV 18, is associated with the onset of various malignant diseases, including cervical carcinoma in women. HPV DNA testing is thus being implemented as a complementary method to standard cytological examination, mainly due to its increased sensitivity. AIM: This review outlines the role of HPV in cervical carcinogenesis, with a focus on the formation of cervical intraepithelial neoplasias (CIN1-3) and the molecular mechanism underlying cellular transformation...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488780/-pedicled-flaps-for-reconstruction-of-head-and-neck-region
#11
Richard Pink, Zdeněk Dvořák, Petr Heinz, Petr Michl, Petr Tvrdý, Bsel Azar
BACKGROUND: There has been a consistent increase in the number of publications on pedicled flaps for the reconstruction of post ablation defects in the oropharyngeal area. In principle, tissue is lifted from a donor site and moved to a recipient site without disruption of blood supply. The donor site is an exact anatomically defined region of tissue that is capable of sustaining its own blood supply. The benefits of pedicled flaps include lower technical demands that obviate the need for microsurgical anastomosis and shorter operating times...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488779/-patient-with-three-egfr-mutations-gradual-development-of-resistance-to-previous-targeted-treatment
#12
Martin Svatoň, Miloš Pešek, Jan Baxa, Petr Mukenšnabl, Lucie Benešová, Marek Minárik
BACKGROUND: Patients with sensitive EGFR mutations are already being treated with first and second generation tyrosine kinase inhibitors (TKIs). However, resistance to these drugs occurs over time, and over half of all cases is caused by a mutation (T790M) in the EGFR kinase domain. Osimertinib offers a new treatment option that overcomes this problem. Unfortunately, resistance to this drug also develops after several months of treatment and is caused by another mutation (C797S) in EGFR...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488778/surgical-treatment-of-ampullary-adenocarcinoma-single-center-experience-and-a-review-of-literature
#13
Lumír Kunovský, Zdeněk Kala, Vladimír Procházka, Martin Potrusil, Milan Dastych, Ivo Novotný, Tomáš Andrasina, Zdeněk Pavlovský, Michal Eid, Petr Moravcik
BACKGROUND: Adenocarcinomas of ampulla of the Vater are relatively uncommon tumors of the gastrointestinal tract. In premalignant lesions endoscopic treatment predominate. According to some authors even early adenocarcinomas (limited to mucosa) can be solved endoscopically. In malignant lesions affecting deeper layers (including submucosa) surgical therapy is the most important. The article summarises the current view for a surgical treatment of ampullary adenocarcinomas and presents results concerning our group of patients...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488777/non-melanoma-skin-cancer-a-clinicopathological-study-of-patients-with-basal-cell-carcinoma-and-squamous-cell-carcinoma
#14
Vladimír Bartoš, Milada Kullová
BACKGROUND: Non-melanoma skin cancer (NMSC) is the most common malignancy in Caucasians. It mainly includes two major keratinocyte tumors - basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The objective of the study was to analyze and compare the clinicopathological differences between patients with BCC and SCC of the skin. MATERIAL AND METHODS: A cohort of 541 patients with a total of 719 BCCs, and 126 patients with a total of 162 SCCs were retrospectively analyzed...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488776/-current-status-of-checkpoint-inhibitors-in-the-treatment-of-esophageal-and-gastric-tumors-overview-of-studies
#15
David Vrána, Marcel Matzenauer, Bohuslav Melichar
BACKGROUND: Despite recent advances in oncological treatment, gastric and esophageal cancer remain neoplastic diseases with poor prognoses. The only potential curative treatment is surgical resection with adjuvant or neoadjuvant chemotherapy/chemoradiotherapy. Targeted therapy of metastatic disease unfortunately does not provide better outcomes than for other tumor types, with the exception of trastuzumab and ramucirumab, which have relatively limited efficacy. Immunotherapy is a rapidly evolving treatment that has influenced the treatment guidelines for many tumors...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488775/-cancer-treatment-induced-changes-in-renal-function-in-patients-with-tumors-update-on-current-knowledge
#16
Tomáš Pokrivčák, Alexandr Poprach
BACKGROUND: Renal abnormalities associated with malignancy are common with renal impairment occurring in about 60% of patients with tumors. Kidney disease may occur as a result of direct or indirect effects of tumors on kidneys and the urinary tract. Systematic oncology treatment can affect renal function in two ways, via direct toxic effects on kidney structure and indirectly via dehydration or tumor lysis syndrome. Since 2004, the Food and Drug Administration has approved a number of potentially nephrotoxic chemotherapeutics, targeted drugs, and immunotherapeutics for the treatment of solid tumors...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488774/-controversy-over-the-use-of-proton-therapy-for-the-treatment-of-tumors-of-central-nervous-system
#17
Jiří Petera
BACKGROUND: Proton beam therapy (PBT) is one of the most discussed topics in contemporary oncology. PBT is characterized by certain physical properties that make it theoretically better as a treatment than standard photon therapy. On the other hand, there are some uncertainties regarding the localization of the dose peak (Bragg peak) in real clinical situations and the value of radiobiological effectiveness at the end of proton beam. Unfortunately, the high expectations of PBT have not been fulfilled in published clinical studies...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488773/-curcumine-turmeric-curcuma-longa-as-a-supportive-phytotherapeutic-treatment-in-oncology
#18
Z Frassová, J Rudá-Kučerová
BACKGROUND: Turmeric (Curcuma longa) is mainly known as a constituent of curry spice. The main active ingredient, responsible for most of its biological effects, is the polyphenol curcumin. AIM: This review aims to provide a comprehensive overview of studies evaluating the benefits of therapeutic curcumin use in oncology. Preclinical studies provide information on the mechanism of action and potential toxicity of curcumin. Clinical studies have so far focused mainly on safety, pharmacokinetics, and determination of the optimal dose of curcumin...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29488772/-ar-v7-androgen-receptor-variant-as-a-predictor-of-response-to-androgen-receptor-targeting-agents-used-to-treat-castration-refractory-metastatic-prostate-cancer
#19
Tomáš Büchler, Vladimír Bobek, Katarína Kološtová
BACKGROUND: Several systemic treatment options are currently available for patients with metastatic castration-refractory prostate cancer (mCRPC), including the androgen-receptor targeting agents (ARTA) enzalutamide and abiraterone, the taxanes docetaxel and cabazitaxel, and the radioisotope drug 223-radium dichloride. In some patients with mCRCP, alternative splicing of androgen receptor (AR) mRNA occurs, resulting in the formation of a truncated AR lacking the androgen-binding domain...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29271218/the-role-of-adjuvant-radiotherapy-in-the-treatment-of-papillary-tumors-of-the-pineal-region-some-general-considerations-and-a-case-report
#20
A Lancia, G Ingrosso, R Santoni
BACKGROUND: Papillary tumor of the pineal region (PTPR) is a recently defined tumor entity. Its clinical course is characterized by frequent local recurrence, and patients may experience the burden of symptoms due to the anatomical location of the growing mass. Guidelines for treatment protocols, and the role of radiotherapy are still being investigated. CASE: We report the case of a 27-year old woman who was referred to our department after she was diagnosed with PTPR and had undergone multiple surgical interventions...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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