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Osasenaga Macdonald Ighodaro, Abiola Mohammed Adeosun, Oluseyi Adeboye Akinloye
Glycemic homeostasis refers to glucose balance or control within circulation in living organisms. It is normally and largely compromised in diabetes. The compromise when exacerbated, leads to several complications including retinopathy, nephropathy and neuropathy which are collectively known as diabetic complications and are the principal actors in co-morbidity and eventual mortality often associated with diabetes. The ability of therapeutic compounds including medicinal plants to restore glycemic balance or homeostasis in hyperglycemic condition is an index of their antidiabetic function and relevance...
February 27, 2018: Medicina
Ingrida Ulozienė, Milda Totilienė, Andrius Paulauskas, Tomas Blažauskas, Vaidotas Marozas, Diego Kaski, Virgilijus Ulozas
BACKGROUND AND OBJECTIVE: The subjective visual vertical (SVV) is a measure of a subject's perceived verticality, and a sensitive test of vestibular dysfunction. Despite this, and consequent upon technical and logistical limitations, SVV has not entered mainstream clinical practice. The aim of the study was to develop a mobile virtual reality based system for SVV test, evaluate the suitability of different controllers and assess the system's usability in practical settings. MATERIALS AND METHODS: In this study, we describe a novel virtual reality based system that has been developed to test SVV using integrated software and hardware, and report normative values across healthy population...
February 19, 2018: Medicina
Greta Musteikienė, Skaidrius Miliauskas, Jurgita Zaveckienė, Marius Žemaitis, Astra Vitkauskienė
OBJECTIVE: The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment. MATERIALS AND METHODS: A total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), they were asked about smoking, alcohol use, living conditions and education. Body mass index (BMI) measurements, laboratory tests (C reactive protein [CRP], vitamin D, albumin) were performed, and chest X-ray was done...
February 9, 2018: Medicina
Bronius Žaliūnas, Daiva Bartkevičienė, Gražina Drąsutienė, Algirdas Utkus, Juozas Kurmanavičius
Ultrasound imaging in obstetrics and gynecology dates back to 1958 when The Lancet published the first article about the use of ultrasonography for fetal and gynecological assessments. It is now almost inconceivable, 60 years later, to think of effective performance in obstetrics and gynecology without the variety of ultrasound, for example, real time imaging, power and color Doppler, 3D/4D ultrasonography, etc. Such examinations facilitate the assessment of intrauterine fetal growth and development during pregnancy, provide alerts about the risk of pre-eclampsia and preterm birth, help identify anatomic reasons for infertility, diagnose ectopic pregnancies, uterine, ovary and tubal pathology...
February 9, 2018: Medicina
Aivara Urbutė, Marija Paulionytė, Domicelė Jonauskaitė, Eglė Machtejevienė, Rūta J Nadišauskienė, Žilvinas Dambrauskas, Paulius Dobožinskas, Mindaugas Kliučinskas
BACKGROUND AND OBJECTIVES: There are only few training programs in obstetric emergencies currently in use and only some of them were evaluated with an adequate sample of participants. Therefore, we present the evaluation of the novel Standardized Trainings in Obstetrical Emergencies (STrObE), conducted in Lithuania. The aim of this study was to analyze whether participants' self-reported knowledge and confidence increased after the trainings, and whether the impact of the trainings was long-lasting...
February 8, 2018: Medicina
Dario Piombino-Mascali, Rimantas Jankauskas, Justina Kozakaitė, M Linda Sutherland
An anthropogenic human mummy curated in the Museum of the History of Medicine, Vilnius University, was recently examined by means of computed tomography. Although the mummy lacked data regarding its specific context and historical information on its identity and chronology, the investigation focused on the embalming method adopted to preserve it. Some pathological alterations were also recorded. This research appears to suggest that this body was prepared for educational and/or scientific purposes rather than funerary purposes...
February 8, 2018: Medicina
Diana Obelienienė, Raminta Macaitytė, Renata Balnytė, Rūta Pėstininkaitė, Rymantė Gleiznienė, Jūratė Balčiūnienė
Susac syndrome is characterized by a clinical triad of encephalopathy, branch retinal artery occlusion, and hearing loss. Due to the absence of the whole complex of the triad in the majority of cases at disease presentation, the syndrome often remains underdiagnosed and untreated. Headache is estimated to affect up to 80% of Susac syndrome patients, but the relevance of headache characteristics and profile is not yet clear. The proposed diagnostic criteria of the European Susac Consortium acknowledge headache as a possible brain manifestation if it is new, described as migrainous or oppressive, and precedes the other symptoms by not more than 6 months...
February 3, 2018: Medicina
Ícaro J S Ribeiro, Rafael Pereira, Paulo F Valença Neto, Ivna V Freire, Cezar A Casotti, Mitermayer Galvão Dos Reis
BACKGROUND AND OBJECTIVE: Diabetes mellitus is one of the most common non-communicable diseases (NCDs) and may influence the autonomic nervous system. This study aims to analyze the autonomic control, through heart rate variability (HRV), from community-dwelling elders with (DM+) and without diabetes mellitus (DM-). MATERIALS AND METHODS: This cross-sectional study, in which 205 elders (≥ 60 years old), from the urban area of Aiquara municipality gave their written consent to participate...
February 3, 2018: Medicina
In Wook Hwang, Yun Dan Kang, Bit Na Kwon, Jun Ho Hong, Seung Hun Han, Jong Soo Kim, Jin Wan Park, Han Jun Jin
BACKGROUND AND OBJECTIVE: The MTHFR gene encodes the methylenetetrahydrofolate reductase known to be involved in the homocysteine-methionine pathway. It has been reported that the deficiency of MTHFR activity may cause hyperhomocysteinemia which results in adverse pregnancy outcomes. Previous studies reported a correlation between the MTHFR gene polymorphisms (677 T/C and 1298 A/C) and lower MTHFR activity and its association with preterm birth in various populations. Since these results were conflicting, we analyzed the genetic association of MTHFR gene 677 T/C and 1298 A/C polymorphisms with preterm birth in Korean women...
February 3, 2018: Medicina
Juris Vanags, Renārs Erts, Guna Laganovska
BACKGROUND AND OBJECTIVE: This study sought to evaluate anterior capsulorhexis opening (ACO) reductions after surgery for a subluxated lens. Significant reduction of an ACO supports direct zonular involvement (capsular factors excluded by use of capsular tension rings [CTRs] and modern intraocular lens [IOLs]), and these findings question the long-term efficacy of subluxated lens surgery by means of cataract surgery. A small ACO due to lens mobility, non-enlargement of the ACO, and no lens epithelial cell washing due to an additional risk of further zonular damage were left as additional features to evaluate the possible outcomes of this simplified but still complicated surgery...
December 14, 2017: Medicina
Liudmyla M Sokurenko, M O Savchyna, V I Litus, R F Kaminsky, Yurii B Сhaikovsky
BACKGROUND AND OBJECTIVE: Mercury pollution is one of the most pressing environmental problems. Therefore, the impact of mercury on human body, the nervous system in particular, remains topical. The aim of the study was to identify the morphological characteristics of neurons and neuroglia in spinal ganglia of rats receiving antioxidants in the presence of small doses of mercury (II) chloride. MATERIALS AND METHODS: A total of 100 white Wistar rats were divided into 5 series (10 groups), with 10 animals in each group...
November 29, 2017: Medicina
Neringa Baranauskienė, Sandra Kilikevičienė, Loreta Stasiulė, Genuvaitė Civinskienė, Arvydas Stasiulis
BACKGROUND AND OBJECTIVE: Unaccustomed eccentric or eccentric-concentric exercise leaves us stiff and sore the next day and can cause muscle damage. The data about the residual effect of prior eccentric-concentric exercises on oxygen uptake (VO2) during constant cycling exercise in women or the data about differences of such effect between genders are scarce. Therefore, the aim of this study was to assess differences of the residual effect of PDJ on VO2 during HCE and indirect muscle damage parameters between women and men...
November 1, 2017: Medicina
Laima Bulotaitė, Dovilė Šorytė, Sigita Vičaitė, Rasa Šidagytė, Svetlana Lakiša, Ivars Vanadziņš, Lāsma Kozlova, Maija Eglīte, Leila Hopsu, Anne Salmi, Jaana Lerssi-Uskelin
BACKGROUND AND OBJECTIVE: Health care workers (HCWs) have a great background to promote their health - not only their professional knowledge on health but often also special equipment in their work environment. However, it is unclear if HCWs can use such infrastructure to promote their own health as well as what is their motivation to change their own lifestyles. Thus, the aim of the article was to describe workplace health promotion (WHP) situation in health care settings in Finland, Latvia, and Lithuania...
October 31, 2017: Medicina
Giovanni Piumatti
BACKGROUND AND OBJECTIVE: The relationship between income and health in late life is well established, but the link between subjective financial wellbeing (SFW) and self-rated health (SRH) has been relatively ignored, especially among elderly in Europe. Adopting a longitudinal person-oriented analytical approach this study investigates the relationship between SFW and SRH in late life in Italy. MATERIALS AND METHODS: Analysis of the European Statistics on Income and Living Conditions survey (EU-SILC) for the period 2010-2013 in Italy examined these relationships at ages 65-78 (N=1268)...
September 21, 2017: Medicina
Sonja Smiljic
Endocardial endothelium (EE) is essential in the embryonic development of the heart, the optimal contractility and rhythm as well as the remodeling of the heart. Endocardial endothelium affect the contractility of cardiomyocytes through paracrine signaling substances such as nitric oxide (NO), endothelin (ET-1), prostaglandins (PGI2, PGF2, PGE2) and angiotensin II (ANG II). Typical lesions of endocardial endothelium have been described in atrial fibrillation, ischemia/reperfusion injury, cardiac hypertrophy, heart failure, sepsis, myocardial infarction, inflammation and thrombosis...
September 21, 2017: Medicina
Eglė Vaižgėlienė, Žilvinas Padaiga, Daiva Rastenytė, Algimantas Tamelis, Kęstutis Petrikonis, Cornelia Fluit
BACKGROUND AND AIM: In 2013, all residency programs at the Lithuanian University of Health Sciences were renewed into the competency-based medical education curriculum (CBME). In 2015, we implemented the validated EFFECT questionnaire together with the EFFECT-System for quality assessment of clinical teaching in residency training. The aim of this study was to investigate the influence of characteristics of the resident (year of training) and clinical teacher (gender, age, and type of academic position) on teaching quality, as well as to assess areas for teaching quality improvement...
September 7, 2017: Medicina
Giedrimantas Bernotas, Karolis Simaitis, Adomas Bunevičius, Arimantas Tamašauskas
OBJECTIVE: The aim of this study was to evaluate feasibility and safety of stereotactic aspiration with fibrinolysis of deep-seated intracerebral hemorrhages (ICH). MATERIALS AND METHODS: From March 1995 until December 2016, 58 adult patients (34 men and 24 women; mean age of 56.8±11.8 years) presenting with deep-seated spontaneous supratentorial ICH were treated using a minimally invasive technique. Intracerebral hematomas were aspirated until obvious resistance to free-hand suction and subsequent clot fibrinolysis was done using either streptokinase or recombinant tissue-type plasminogen activator...
August 3, 2017: Medicina
Aurelija Noreikaitė, Ieva Antanavičiūtė, Valeryia Mikalayeva, Adas Darinskas, Tomas Tamulevičius, Erika Adomavičiūtė, Linas Šimatonis, Dalia Akramienė, Edgaras Stankevičius
OBJECTIVE: The aim of this study was to test polymeric materials (collagen, fibrin, polyimide film, and polylactic acid) for single- and multi-layer scaffold formation. MATERIALS AND METHODS: In our study, we used rabbit bone marrow stem cells (rBMSCs) and human mesenchymal stem cells (hMSCs) with materials of a different origin for the formation of an artificial scaffold, such as a collagen scaffold, fibrin scaffold produced from clotted rabbit plasma, electrospun poly(lactic acid) (PLA) mats, polyimide film (PI), and the combination of the latter two...
July 13, 2017: Medicina
Laura Tamašauskienė, Edita Hansted, Astra Vitkauskienė, Skaidrius Miliauskas, Albinas Naudžiūnas, Brigita Šitkauskienė
BACKGROUND AND OBJECTIVE: Lithuania belongs to the group of countries with a high-incidence of tuberculosis (TB). Some scientific studies show that the interferon-gamma release assay is more accurate and correlates more highly with TB exposure as compared to the tuberculin skin test (TST). This study aimed at comparing the efficacy between the T SPOT TB and TST for diagnosing TB among Lithuanian adults. MATERIALS AND METHODS: Individuals with diagnosed TB, healthcare workers with known risk for TB and individuals without any known risk for TB underwent clinical examinations, interviews about their history of TB exposure and chest radiography...
July 3, 2017: Medicina
Łukasz Dobrek, Beata Skowron, Agnieszka Baranowska, Klaudia Płoszaj, Dorota Bądziul, Piotr Thor
BACKGROUND AND OBJECTIVE: The application of cytostatic oxazaphosphorines such as cyclophosphamide (CP) and ifosfamide (IF) is associated with the risk of kidney damage that, depending on the type of drug, dose and route of administration, adopts a different clinical entity and severity. The aim of our study was to assess the influence of CP and IF on the kidney histology and function in rats intraperitoneally treated with four doses of either CP or IF. MATERIALS AND METHODS: A total of 30 rats were divided into three groups (10 in each group): group 1 (control), sham treated with saline solution, group 2 (treated with 75mg/kg b...
July 2, 2017: Medicina
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