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Journal of the Egyptian National Cancer Institute

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https://www.readbyqxmd.com/read/29429892/osteosarcoma-subtypes-magnetic-resonance-and-quantitative-diffusion-weighted-imaging-criteria
#1
Rania Zeitoun, Ahmed M Shokry, Sahar Ahmed Khaleel, Shaimaa M Mogahed
INTRODUCTION: Osteosarcoma (OS) is a primary bone malignancy, characterized by spindle cells producing osteoid. The objective of this study is to describe the magnetic resonance imaging (MRI) features of different OS subtypes, record their attenuation diffusion coefficient (ADC) values and to point to the relation of their pathologic base and their corresponding ADC value. PATIENTS AND METHODS: We performed a retrospective observational lesion-based analysis for 31 pathologically proven osteosarcoma subtypes: osteoblastic (n = 9), fibroblastic (n = 8), chondroblastic (n = 6), para-osteal (n = 3), periosteal (n = 1), telangiectatic (n = 2), small cell (n = 1) and extra-skeletal (n = 1)...
February 8, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29428373/first-line-paclitaxel-and-cisplatin-used-sequentially-or-in-combination-in-metastatic-breast-cancer-a-phase-ii-randomized-study
#2
Mostafa M Elserafi, Ahmed A Zeeneldin, Ibrahim M Abdelsalam, Hanan R Nassar, Manar M Moneer, Wafa H Buhoush
INTRODUCTION: Breast cancer (BC) is the commonest cancer among females worldwide. Some patients present initially at advanced stages and more than 50% of them will develop metastasis (MBC) at some point. Compared to single agents, combination chemotherapy produces higher response rates (RR), longer progression-free survival (PFS) than single agents. This is associated with remarkably higher toxicities. At the same time, overall survival (OS) is comparable. This study aimed to compare safety and efficacy of combination and sequential chemotherapy...
February 7, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29428372/comparative-study-on-the-analgesic-effect-of-acute-ipsilateral-shoulder-pain-after-open-thoracotomy-between-preoperative-ultrasound-guided-suprascapular-nerve-block-snb-and-intraoperative-phrenic-nerve-infiltration-pni-in-cancer-lung-patients
#3
Bassel M Elfokery, Sahar A Tawfic, Abdelrahman M Abdelrahman, Dina N Abbas, Ikramy M Abdelghaffar
INTRODUCTION: Acute ipsilateral shoulder pain (ISP) is a common complaint in patients after thoracotomy. The incidence ranges from 21% to 97%. Unfortunately, clinical studies did not put enough focus on ISP post thoracic surgery. AIM OF THE WORK: This study was designed to compare the effectiveness of suprascapular nerve block (SNB) and phrenic nerve infiltration (PNI) for controlling ISP. PATIENTS AND METHODS: One hundred and thirty-five lung cancer patients (135) scheduled for open-lung surgery were randomly allocated into three equal groups; control group: received thoracic epidural with general anesthesia, suprascapular group: (SNB) one hour before the operation with 10 ml bupivacaine plus thoracic epidural with general anesthesia and phrenic nerve group: (PNI) was performed by the operating surgeon with 10 ml bupivacaine plus thoracic epidural with general anesthesia...
February 7, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29428371/survival-outcome-of-intermediate-risk-neuroblastoma-at-children-cancer-hospital-egypt
#4
Hossam Elzomor, Gehad Ahmed, Salma Elmenawi, Naglaa Elkinaai, Amal Refaat, Sonya Soliman, Mai Amr Abdelwahab, Mohamed Saad Zaghloul, Mohamed Fawzy
AIM: The study aims to evaluate survival outcome in newly diagnosed pediatric intermediate risk neuroblastoma patients treated at the Children Cancer Hospital - Egypt and their relation to various clinical and pathological factors. METHODS: The study included stage 3 patients <1.5 years, children 1.5 years or older with stage 3 disease and favorable histopathological features, infants (<1 year) with International Neuroblastoma Staging System (INSS) stage 4 disease, stage 4 children 1-1...
February 7, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29428370/reinforcing-the-utility-of-chick-embryo-model-to-in-vivo-evaluate-engraftment-of-human-leukemic-stem-cells
#5
Arwa Farhat, Eiad Ali-Deeb, Amin Sulaiman, Majd Aljamali
BACKGROUND AND OBJECTIVE: Development of appropriate translational in vivo models is a prerequisite for personalized management of leukemic patients. Indeed, several immunodeficient mice models were developed for leukemias with main limitations due to their high cost, demanding management, and elongated assessment intervals. In this report, we aimed at evaluating the engraftment of CD34+ cells, isolated from an acute myeloid leukemia (AML) patient, in naturally immunodeficient chick embryo model...
February 7, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29428369/radiotherapeutic-factors-affecting-the-incidence-of-developing-hypothyroidism-after-radiotherapy-for-head-and-neck-squamous-cell-cancer
#6
Mohamed El-Shebiney, Nehal El-Mashad, Wael El-Mashad, Ahmed A El-Ebiary, Abdallah E Kotkat
PURPOSE: The purpose of this study is to determine radiotherapy (RT) dose-volumetric threshold of radiation-induced hypothyroidism (HT) in head and neck squamous cell carcinoma (HNSCC) patients. PATIENTS AND METHODS: The diagnosis of HT in 78 HNSCC patients treated with RT was based on a thyroid stimulating hormone (TSH) level greater than the maximum value of laboratory range. In all patients, dose-volumetric parameters were analyzed according to their relation to development of HT, and thyroid volumes spared from doses ≥10, 20, 30, 40 and 50 Gy (V10, V20, V30, V40 and V50) were analyzed from the dose volume histograms (DVHs)...
February 7, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29233453/cytological-diagnosis-of-a-rare-case-of-cutaneous-metastasis-from-transitional-cell-carcinoma-renal-pelvis
#7
Pragya Singh, Sachin Kolte, Gunjesh Kumar Singh
Transitional cell carcinoma (TCC) arising from renal pelvis rarely gives rise to cutaneous metastasis. Due to the insufficient literature, the exact incidence is not known till date. Moreover, the diagnosis is confirmed on histopathological examination with the aid of immunohistochemistry wherever needed. We are presenting a case of a 70-year-old female with metastatic TCC from the renal pelvis to the abdominal skin, which was diagnosed on cytology alone along with the cell block preparation. We also highlight the important cytomorphological and immunohistochemical features noted, which need to be known to avoid any diagnostic delay...
December 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29233452/downregulation-of-caspase-8-in-a-group-of-iranian-breast-cancer-patients-a-pilot-study
#8
Masoumeh Aghababazadeh, Najmeh Dorraki, Fahimeh Afzal Javan, Asieh Sadat Fattahi, Masoumeh Gharib, Alireza Pasdar
PURPOSE: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis. As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been found to be an important gene regarding breast cancer susceptibility. The alterations of the expression of this gene have been reported in breast cancer cell lines. Given that in previous studies expression analysis of this gene had only been done in breast cancer cell lines, in this study we aimed to evaluate the expression of this gene in breast cancer tissues versus adjacent normal tissues, using real-time quantitative method...
December 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29233454/does-radiotherapy-prior-to-surgery-improve-long-term-prognosis-in-pediatric-colorectal-cancer-in-lower-and-upper-middle-income-countries-with-limited-resources-our-experience-and-literature-review
#9
Yacoob Omar Carrim, Luvo Gaxa, Francisca van der Schyff, Nndweleni Meshack Bida, Fareed Omar, Zarina Lockhat
Colorectal carcinoma in children and adolescents is extremely rare, with an annual incidence <0.3 cases per million, most frequently reported in the second decade of life. It accounts for severe morbidity and poor prognosis owing to the low index of suspicion, delayed diagnosis, advanced stage at presentation and the aggressive tumor nature. Patients present with abdominal pain, vomiting, constipation, abdominal distension, rectal tenesmus, iron-deficiency anemia, change in bowel habit and weight loss...
December 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29129577/pelvic-bone-anatomy-vs-implanted-gold-seed-marker-registration-for-image-guided-intensity-modulated-radiotherapy-for-prostate-carcinoma-comparative-analysis-of-inter-fraction-motion-and-toxicities
#10
Madhup Rastogi, Sambit Swarup Nanda, Ajeet Kumar Gandhi, Divakar Dalela, Rohini Khurana, Surendra Prasad Mishra, Anoop Srivastava, S Farzana, Madan Lal Brahma Bhatt, Nuzhat Husain
OBJECTIVES: We compared the prostate motion variability and toxicities between patients treated with gold marker registration based IG-IMRT (IG-IMRT-M) and bony landmark registration based IG-IMRT (IG-IMRT-B). METHODS: T1c-T3b (node negative), intermediate and high risk (non-metastatic) adenocarcinoma of prostate, age ≥18years, Karnofsky Performance Status of ≥70 were included in this retrospective study. The prostate motion variability, acute and late radiation toxicities between the two treatment arms (IG-IMRT-M versus IG-IMRT-B) were compared...
November 9, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29126758/maspin-expression-and-subcellular-localization-in-invasive-ductal-carcinoma-of-the-breast-prognostic-significance-and-relation-to-microvessel-density
#11
Duaa S Helal, Dina M El-Guindy
Maspin (Mammary serine protease inhibitor) is a tumor suppressor serine. Its clinical significance and role in breast carcinoma are contradictory and inconclusive. Researches demonstrated that the function of maspin differs according to its subcellular localization. This study was conducted to investigate the expression of maspin in invasive ductal carcinoma (IDC) of the breast with special emphasis on its subcellular localization and to evaluate its prognostic role in relation to clinicopathological parameters and microvessel density (MVD) of the tumor...
November 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29122511/from-bench-to-clinical-trials-the-eortc-experience-in-biology-based-clinical-cancer-research
#12
REVIEW
Konstantinos Tryfonidis, Katherine Hartmann, Marie Morfouace, Denis Lacombe
For over 50years the European Organization for Research and Treatment of Cancer (EORTC) has delivered major advances in cancer clinical research and cancer therapeutics. The introduction of molecularly targeted agents has led to significant improvements in outcome for patients with specific tumor types; however conventional chemotherapy remains the mainstay of treatment for the majority of patients. Due to increasing knowledge about the diversity of molecular pathways driving malignant progression, strategies to integrate biology into clinical research and development are continuously evolving...
November 6, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28844589/impact-of-cyp1a1-gstp1-and-xrcc1-genes-polymorphisms-on-toxicity-and-response-to-chemotherapy-in-childhood-acute-lymphoblastic-leukemia
#13
Asmaa Abo-Bakr, Ghada Mossallam, Nevin El Azhary, Hanafy Hafez, Ragia Badawy
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The interindividual genetic variations in drug metabolizing enzymes and DNA repair genes influence the efficacy and toxicity of numerous chemotherapeutic drugs affecting the treatment outcome. AIM OF THE WORK: The aim of the study was to investigate the impact of drug metabolizing CYP1, GSTP1 and DNA repair (XRCC1) genes polymorphisms on the toxicity and response to chemotherapy in childhood ALL...
September 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28669452/metaplastic-breast-carcinoma-analysis-of-31-cases-from-a-single-institute
#14
Salah Fayaz, Gerges Attia Demian, Heba El-Sayed Eissa, Henney Amanguno, Sadeq Abuzalouf
PURPOSE: Metaplastic carcinoma of the breast (MBC) accounts for less than 1% of all mammary tumors. This study aimed at revision of the clinico-pathological features, treatment strategy and outcome for MBC patients presented to the Kuwait Cancer Control Center to define the clinical behavior and prognostic factors of these neoplasms in our population. PATIENT AND METHODS: Thirty-one patients were retrieved from our surgical pathology registry between January 2005 and December 2014...
September 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28668495/toward-standardization-of-laparoscopic-resection-for-colorectal-cancer-in-developing-countries-a-step-by-step-module
#15
Ahmed Mostafa Ahmed Mahmoud, Manar Mohamed Moneer
BACKGROUND: Despite the proven benefits, laparoscopic colorectal surgery is still underutilized among surgeons especially in developing countries. Also a steep learning is one of the causes of its limited adoption. OBJECTIVE: To explore the learning curve of single surgeon experience in laparoscopic colectomy and feasibility of implementing a well standardized step by step operative technique to overcome the beginning technical obstacles. PATIENTS AND METHODS: This prospective study included 50 patients with carcinoma of the left colon and rectum recruited from the department of surgical oncology at National Cancer Institute, Cairo University in the period 2012-2016...
September 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28844593/alveolar-soft-part-sarcoma-of-orbit-a-rare-diagnosis
#16
Pritee B Chaudhari, Sushmita Pathy, Suryanarayana S V Deo, Bhavna Chawla, Asit Ranjan Mridha
OBJECTIVE: Alveolar soft part sarcoma (ASPS) is an aggressive, rare tumour with unique morphological and histopathological features. METHODS: We report a rare case of orbital ASPS and its management in a young male who presented with painless proptosis and progressive loss of vision. RESULT: Twenty-two year male presented with a history of gradually increasing proptosis with loss of vision since 12months. He underwent radical re-excision of mass with right orbital exenteration and reconstruction using temporalis muscle flap...
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28844592/adjuvant-radiotherapy-after-radical-cystectomy-and-ileal-orthotopic-neobladder
#17
EDITORIAL
Mohmed S Zaghloul, Tarek M Zaghloul
No abstract text is available yet for this article.
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28844591/addition-of-3-day-aprepitant-to-ondansetron-and-dexamethasone-for-prophylaxis-of-chemotherapy-induced-nausea-and-vomiting-among-patients-with-diffuse-large-b-cell-lymphoma-receiving-5-day-cisplatin-based-chemotherapy
#18
Raafat Abdel-Malek, Noha Abbas, Kyrillus S Shohdy, Mohamed Ismail, Radwa Fawzy, Dalal S Salem, Ezzat Safwat
BACKGROUND: Neurokinin-1 receptor antagonists, such as aprepitant are currently emerging as powerful prophylactic agents for chemotherapy-induced nausea and vomiting (CINV). Therefore, it is important to adjust the anti-emetic regimens based on personal risk factors of the patient, duration of the chemotherapy regimen and cost-effectiveness. PURPOSE: To determine the efficacy of the 3-day aprepitant along with ondansetron and dexamethasone in controlling CINV in patients with large B cell lymphoma receiving multiday-cisplatin regimen chemotherapy...
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28844590/surgical-approaches-anaesthetic-management-and-outcome-in-pediatric-superior-mediastinal-tumors
#19
Gehad Ahmed, Mohammed M Hegazy, Tarek Raafat, Hanafy Hafez, Sayed Fadel, Maged Elshafiey
BACKGROUND: Pediatric superior mediastinal tumors are a heterogeneous group of tumors with marked variation in pathology and extension. We reviewed our experience with different surgical approaches to tumors originating from or extending to superior mediastinum in pediatrics. PATIENTS AND METHODS: The medical records of all patients who had undergone resection for superior mediastinal tumors in Children's Cancer Hospital - Egypt, between January 2008 to December 2015, were reviewed for demographic data, clinico-pathological features, radiologic findings, operative techniques and outcome...
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28673746/unilateral-proptosis-as-the-initial-manifestation-of-malignancy
#20
K Rakul Nambiar, P S Ajith, Asha Arjunan
Proptosis, a common sign with a broad differential diagnosis, is defined as anterior displacement and protrusion of one or both orbital globes. Patients can present with varying degrees of chronicity, visual loss and associated symptoms. The etiology of acquired unilateral proptosis is diverse, ranging from benign to life-threatening. The causes of unilateral proptosis include traumatic, vascular, endocrine, inflammatory, infective and malignant. Breast carcinoma is the most common metastatic cause of proptosis; however, proptosis has never been reported as the initial manifestation of breast carcinoma...
June 30, 2017: Journal of the Egyptian National Cancer Institute
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