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Journal of the Egyptian National Cancer Institute

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https://www.readbyqxmd.com/read/30337185/programmed-cell-death-ligand-1-pd-l1-expression-combined-with-cd8-tumor-infiltrating-lymphocytes-density-in-non-small-cell-lung-cancer-patients
#1
Dina M El-Guindy, Duaa S Helal, Nesreen M Sabry, Mohamed Abo El-Nasr
Cancer immunotherapy targeting programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway has shown promising results in treatment of non-small cell lung cancer (NSCLC) patients. T cells play a major role in tumor-associated immune response. This study aimed to investigate PD-L1 expression alone and combined with CD8 tumor infiltrating lymphocytes (TILs) density in relation to clinicopathologic parameters and survival in NSCLC patients. Immunohistochemical analysis was used to evaluate PD-L1 expression and CD8 TILs density in 55 NSCLC patients...
October 15, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/30327215/axillary-metastasis-in-clinically-node-negative-breast-cancer
#2
Orhan Üreyen, Demet Kocatepe Çavdar, Zehra Hilal Adıbelli, Enver İlhan
AIM OF WORK: This study investigates the factors related to metastasis detection in a sentinel lymph node biopsy (SLN) in patients without clinical axillary involvement. PATIENTS AND METHODS: The medical records of patients who underwent an SLN biopsy after diagnosis with early-stage breast cancer were evaluated retrospectively. The study sample included 64 patients divided into two groups according to the histopathological examination of the SLN biopsy: Group I (positive for axillary metastasis) and Group II (negative for axillary metastasis)...
October 13, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/30177227/corrigendum-to-osteosarcoma-of-the-jaw-challenges-in-the-diagnosis-and-treatment-j-egypt-natl-cancer-inst-2018-7-11
#3
Mohamed Atef ElKordy, Tarek Sherif ElBaradie, Hisham Ismail ElSebai, Sheriff Mohamed Khairalla, Ayman AbdelWahab Amin
No abstract text is available yet for this article.
September 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/30145025/health-related-quality-of-life-after-urinary-diversion-which-technique-is-better
#4
Ahmed M Moeen, Ahmed S Safwat, Mohamed M Gadelmoula, Seham M Moeen, Ahmad Elbadry I Abonnoor, Walid M Abbas, Ehab O ElGanainy, Ahmed M El-Taher
OBJECTIVE: To compare quality of life (QoL) after urinary diversion (UD) following radical cystectomy (RC) using validated questionnaires. PATIENTS AND METHODS: Between January 2011 and June 2016, 150 patients (121 men [80.7%] and 29 women [19.3%]) with invasive bladder cancer who underwent RC and UD were included in this prospective study. Patients were divided into 2 groups; group I included the orthotopic neobladder 50 (33.3%) and uretro-sigmoidostomy 41 (27...
September 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/30143404/inter-observer-reproducibility-of-the-royal-college-system-for-reporting-thyroid-cytology-experience-of-the-egyptian-national-cancer-institute
#5
Noha E Ezzat, Eman S Abusinna, Nesreen H Hafez, Nelly H Alieldin
PURPOSE: To assess the inter-observer agreement between 3 cytopathologists of thyroid FNAC using Royal College of Pathology reporting system. PATIENTS AND METHODS: The study is a retrospective one conducted on 204 cases retrieved from the archives of the Cytology Unit, Pathology Department, National Cancer Institute, Cairo University during the time period from January 2016 to December 2016. Cases were diagnosed separately by 3 cytopathologists using the Royal College of Pathology classification system (RCPath), where Thy1, nondiagnostic; Thy2, nonneoplastic; Thy3a, atypical, Thy3f, follicular lesion; Thy4, suspicious of malignancy; and Thy5, malignant...
September 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/30143403/ultrasound-guided-venous-access-wire-loaded-puncture-technique-for-paediatric-cancer-patients
#6
Kareem Sallam, Ahmed Refaat, Marwa Romeih
Ultrasound-guided venous access is becoming a standard technique in many centers worldwide. In small veins and in the pediatric population, successful venous puncture is sometimes followed by resistance in passing the wire. The needle seems to miss the small vein during syringe dismounting, wire mounting and wire advancement through the needle. This work describes a "wire-loaded puncture" technique as a solution for this problem. PATIENTS AND METHODS: Paediatric cancer patients who needed venous access for different indications were included in the study...
September 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29960876/randomized-controlled-study-comparing-simultaneous-modulated-accelerated-radiotherapy-versus-simultaneous-integrated-boost-intensity-modulated-radiotherapy-in-the-treatment-of-locally-advanced-head-and-neck-cancer
#7
Sarthak Tandon, Munish Gairola, Parveen Ahlawat, Sheh Rawat, Archana Aggarwal, Kanika Sharma, Sandeep Tiwari, Ahmad M Karimi, Vinayakumar Muttagi, Nishtha Sachdeva, Manindra Bhushan
OBJECTIVES: Comparison of two fractionation schedules of intensity modulated radiotherapy (IMRT) for locally advanced head and neck cancer - simultaneous integrated boost (SIB-IMRT) and simultaneous modulated accelerated radiotherapy (SMART) boost in terms of toxicity and survival end-point measures. PATIENTS AND METHODS: Sixty patients with locally advanced head and neck cancer were randomized in two treatment arms (SIB-IMRT [control arm] and SMART boost arm [study arm])...
September 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29958780/combined-percutaneous-radiofrequency-ablation-and-cementoplasty-for-the-treatment-of-extraspinal-painful-bone-metastases-a-prospective-study
#8
Andrew Fares, Mohamed H Shaaban, Raafat M Reyad, Ahmed S Ragab, Mohga A Sami
INTRODUCTION: About 50% of patients with cancer develop bone metastasis mainly presenting with distressing, drug-resistant pain. AIM OF THE WORK: The study evaluated efficacy and safety of combined cementoplasty and bony radiofrequency ablation in palliation of intractable pain and disability in cancer patients with bony metastases. PATIENTS AND METHODS: The study included 30 adult patients suffering from localized bony metastases causing refractory moderate to severe pain...
September 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29779939/endometrial-carcinoma-in-a-single-horn-of-a-bicornuate-uterus-a-case-report
#9
Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni Scambia
We discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy. The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn showed a neoplastic growth of 10 cm with infiltration of about 1,8 cm of the myometrium from whole thickness of 1...
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29779938/expression-of-truncated-her2-and-its-prognostic-value-in-her2-positive-breast-cancer-patients
#10
Alaa Mohamed Maria, Mohamed El-Shebiney, Ayman Mohamed El-Saka, Yomna Zamzam
PURPOSE: The purpose of this work was to assess the truncated form of human epidermal growth factor receptor 2 (HER2) such as p95-HER2 expression in HER2-positive breast cancer (BC) patients who developed metastatic disease after adjuvant treatment with a trastuzumab-containing regimen. PATIENTS AND METHODS: Thirty-two histologically diagnosed HER2-positive BC patients who developed distant failure after treatment with trastuzumab-based chemotherapy (CT) regimen as an adjuvant therapy were included in the study...
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29779937/estrogen-receptor-positive-breast-tumors-resist-chemotherapy-by-the-overexpression-of-p53-in-cancer-stem-cells
#11
Fatma Ashour, Mohammed H Awwad, Hayam E L Sharawy, Mohamed Kamal
BACKGROUND AND OBJECTIVES: Breast cancer (BC) is classified according to estrogen receptor (ER) status into ER+ and ER- tumors. ER+ tumors have a worse response to chemotherapy compared to ER- tumors. BCL-2, TP53, BAX and NF-ΚB are involved in drug resistance in the ER+ tumors. Recently it was shown that Cancer Stem Cells (CSCs) play an important role in drug resistance. In this study we tested the hypothesis that CSCs of the ER+ tumors resist drug through the overexpression of BCL-2, TP53, BAX and NF-ΚB...
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29699873/report-of-a-unique-case-of-myoepithelial-carcinoma-of-left-parotid-gland-with-metachronous-bilateral-cavernous-sinus-metastasis
#12
Rambha Pandey, Rituparna Biswas, Mukurdipi Ray, Prashant P Ramteke, Ekta Dhamija, Anirban Halder
Myoepithelial carcinoma (MC) is a rare, locally aggressive malignant neoplasm of the salivary glands. Only few evidences on its metastatic behavior are available in the literature. We herein present a unique case of MC of left parotid gland which metastasized to bilateral cavernous sinuses. The patient was successfully treated with palliative radiotherapy and chemotherapy.
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29691096/prevalence-of-lung-cancer-in-isfahan-province-iran
#13
Zahra Tolou Ghamari
OBJECTIVE: To describe for the first time period prevalence (PP) and incidence rate (Ir) for patients with lung cancer in Isfahan Province/Iran. DESIGN: Data associated to the Surveillance, Epidemiology, and End Results; (SEER) was collected from the Isfahan Cancer Registry from March 2011 to March 2015. Lung cancer was distinguished by the related established topography code. PP and Ir were calculated and expressed per 100,000 persons. RESULTS: In all, 548 females and 1399 males were identified...
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29691095/role-of-hydroxyurea-as-an-adjuvant-treatment-after-gamma-knife-radiosurgery-for-atypical-who-grade-ii-meningiomas
#14
Khalid Abdel Karim, Amr El Shehaby, Reem Emad, Wael Reda, Manal El Mahdy, Ramy Ghali, Ahmed Nabeel
No abstract text is available yet for this article.
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29691094/first-experience-of-the-egyptian-national-cancer-institute-using-the-robot-assisted-laparoscopic-approach-in-radical-hysterectomies-for-cervical-cancer
#15
Ashraf Saad Zaghloul, Ahmed Mahmoud El-Minawi, Mohamed Atef ElKordy, Amr Kamal Younes, Ahmed Mostafa Mahmoud, Waleed Mohamed Fadlalla, Gamal Amira Mohamed
AIM OF WORK: Robotics in surgery led to an improvement of visualization, a better handling of tissues and better suturing. This study aimed to document the first experience of the Egyptian National Cancer Institute (NCI) using the robot-assisted laparoscopic approach in radical hysterectomies for cervical cancer and to highlight observed advantages, disadvantages, morbidity and oncological outcomes. PATIENTS AND METHODS: Data of cases that had either early cervical cancer (stage IB-IIA1 with a tumor ≥2 cm) or locally advanced cervical cancer (Stage IIA2-IIB after chemo-radiotherapy) were collected prospectively...
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29680448/the-role-of-intraoperative-radiotherapy-iort-in-the-management-of-patients-with-pancreatic-and-periampullary-cancer-a-single-center-experience
#16
Ayman Zaki Azzam, Ahmed Alqarni, Tarek Mahmoud Amin
BACKGROUND: In spite of the advances in modern surgery, the outcome for patients suffering from pancreatic adenocarcinoma or periampullary adenocarcinoma is still bad. Recently, introperative radiotherapy (IORT) was introduced into the multimodality management approach to improve both tumor control and patient' survival. AIM OF WORK: To evaluate our initial experience in combined surgical resection and IORT, and to evaluate the feasibility of the application of IORT and its effect on morbidity, mortality and local recurrence...
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29490886/osteosarcoma-of-the-jaw-challenges-in-the-diagnosis-and-treatment
#17
Mohamed Atef ElKordy, Tarek Sherif ElBaradie, Hisham Ismael ElSebai, Ayman Abd ElWahab Amin, Sheriff Mohamed KhairAlla
PURPOSE: Osteosarcomas rarely affect jaw bones. Patients are usually older than those who suffer long bone sarcomas, with a rare incidence of metastasis. This is suggestive of a different pattern of behavior compared with long bone sarcomas. This study aimed to present NCI, Cairo University experience in treating patients diagnosed with osteosarcomas of the jaw, including the diagnostic challenges and treatment outcome. PATIENTS AND METHODS: This is a retrospective case series study of all cases of osteosarcomas of mandible and maxilla that were treated at the NCI, in the period between 2006 and 2013...
March 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29429892/osteosarcoma-subtypes-magnetic-resonance-and-quantitative-diffusion-weighted-imaging-criteria
#18
Rania Zeitoun, Ahmed M Shokry, Sahar Ahmed Khaleel, Shaimaa M Mogahed
INTRODUCTION: Osteosarcoma (OS) is a primary bone malignancy, characterized by spindle cells producing osteoid. The objective of this study is to describe the magnetic resonance imaging (MRI) features of different OS subtypes, record their attenuation diffusion coefficient (ADC) values and to point to the relation of their pathologic base and their corresponding ADC value. PATIENTS AND METHODS: We performed a retrospective observational lesion-based analysis for 31 pathologically proven osteosarcoma subtypes: osteoblastic (n = 9), fibroblastic (n = 8), chondroblastic (n = 6), para-osteal (n = 3), periosteal (n = 1), telangiectatic (n = 2), small cell (n = 1) and extra-skeletal (n = 1)...
March 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29428373/first-line-paclitaxel-and-cisplatin-used-sequentially-or-in-combination-in-metastatic-breast-cancer-a-phase-ii-randomized-study
#19
RANDOMIZED CONTROLLED TRIAL
Mostafa M Elserafi, Ahmed A Zeeneldin, Ibrahim M Abdelsalam, Hanan R Nassar, Manar M Moneer, Wafa H Buhoush
INTRODUCTION: Breast cancer (BC) is the commonest cancer among females worldwide. Some patients present initially at advanced stages and more than 50% of them will develop metastasis (MBC) at some point. Compared to single agents, combination chemotherapy produces higher response rates (RR), longer progression-free survival (PFS) than single agents. This is associated with remarkably higher toxicities. At the same time, overall survival (OS) is comparable. This study aimed to compare safety and efficacy of combination and sequential chemotherapy...
March 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29428372/comparative-study-on-the-analgesic-effect-of-acute-ipsilateral-shoulder-pain-after-open-thoracotomy-between-preoperative-ultrasound-guided-suprascapular-nerve-block-snb-and-intraoperative-phrenic-nerve-infiltration-pni-in-cancer-lung-patients
#20
Bassel M Elfokery, Sahar A Tawfic, Abdelrahman M Abdelrahman, Dina N Abbas, Ikramy M Abdelghaffar
INTRODUCTION: Acute ipsilateral shoulder pain (ISP) is a common complaint in patients after thoracotomy. The incidence ranges from 21% to 97%. Unfortunately, clinical studies did not put enough focus on ISP post thoracic surgery. AIM OF THE WORK: This study was designed to compare the effectiveness of suprascapular nerve block (SNB) and phrenic nerve infiltration (PNI) for controlling ISP. PATIENTS AND METHODS: One hundred and thirty-five lung cancer patients (135) scheduled for open-lung surgery were randomly allocated into three equal groups; control group: received thoracic epidural with general anesthesia, suprascapular group: (SNB) one hour before the operation with 10 ml bupivacaine plus thoracic epidural with general anesthesia and phrenic nerve group: (PNI) was performed by the operating surgeon with 10 ml bupivacaine plus thoracic epidural with general anesthesia...
March 2018: Journal of the Egyptian National Cancer Institute
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