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Journal of the Egyptian National Cancer Institute

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https://www.readbyqxmd.com/read/28673746/unilateral-proptosis-as-the-initial-manifestation-of-malignancy
#1
K Rakul Nambiar, P S Ajith, Asha Arjunan
Proptosis, a common sign with a broad differential diagnosis, is defined as anterior displacement and protrusion of one or both orbital globes. Patients can present with varying degrees of chronicity, visual loss and associated symptoms. The etiology of acquired unilateral proptosis is diverse, ranging from benign to life-threatening. The causes of unilateral proptosis include traumatic, vascular, endocrine, inflammatory, infective and malignant. Breast carcinoma is the most common metastatic cause of proptosis; however, proptosis has never been reported as the initial manifestation of breast carcinoma...
June 30, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28669452/metaplastic-breast-carcinoma-analysis-of-31-cases-from-a-single-institute
#2
Salah Fayaz, Gerges Attia Demian, Heba El-Sayed Eissa, Henney Amanguno, Sadeq Abuzalouf
PURPOSE: Metaplastic carcinoma of the breast (MBC) accounts for less than 1% of all mammary tumors. This study aimed at revision of the clinico-pathological features, treatment strategy and outcome for MBC patients presented to the Kuwait Cancer Control Center to define the clinical behavior and prognostic factors of these neoplasms in our population. PATIENT AND METHODS: Thirty-one patients were retrieved from our surgical pathology registry between January 2005 and December 2014...
June 29, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28669451/cancer-incidence-and-mortality-are-associated-with-human-development-index-and-health-setups-in-africa
#3
Ruqiya Pervaiz, Faisal Faisal
BACKGROUND: This study aimed to analyse the correlation between cancer incidence and mortality and the Human Development Index (HDI) in Africa. Furthermore, to analyse the variations in cancer Mortality to Incidence Ratio (MIR) based on health care systems in African countries. MATERIAL AND METHODS: Cancer incidence and mortality data for 53 countries were obtained from GLOBOCAN database. Country-wise data on National-HDI were obtained from Human Development Report 2015...
June 29, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28668495/toward-standardization-of-laparoscopic-resection-for-colorectal-cancer-in-developing-countries-a-step-by-step-module
#4
Ahmed Mostafa Ahmed Mahmoud, Manar Mohamed Moneer
BACKGROUND: Despite the proven benefits, laparoscopic colorectal surgery is still underutilized among surgeons especially in developing countries. Also a steep learning is one of the causes of its limited adoption. OBJECTIVE: To explore the learning curve of single surgeon experience in laparoscopic colectomy and feasibility of implementing a well standardized step by step operative technique to overcome the beginning technical obstacles. PATIENTS AND METHODS: This prospective study included 50 patients with carcinoma of the left colon and rectum recruited from the department of surgical oncology at National Cancer Institute, Cairo University in the period 2012-2016...
June 28, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28668494/lung-metastasis-in-primary-cutaneous-adenoid-cystic-carcinoma-clinicopathological-evaluation-of-a-rare-case-with-review-of-literature
#5
Gunjesh Kumar Singh, Pragya Singh, Jaspreet Kaur, Rakesh Kumar
Primary cutaneous adenoid cystic carcinoma (ACC) is an extremely rare and indolent cutaneous malignancy with very infrequent distant metastasis. We present a case of primary cutaneous ACC with bilateral lung metastases in a 57-year-old male along with literature review. To the best of our knowledge this is the tenth case of primary cutaneous ACC reported presenting with distant metastasis.
June 28, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28601426/corrigendum-to-risk-stratification-and-pattern-of-cardiotoxicity-in-pediatric-ewing-sarcoma-j-egypt-natl-cancer-instit-29-2017-53-56
#6
Emad Moussa, Manal Zamzam, Ahmed Kamel, Zeinab Salah, Iman Attia, Lina Gaber, Ranin Soliman, Sameera Ezzat
No abstract text is available yet for this article.
June 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28455004/editor-s-perspective-on-the-4th-edition-of-the-who-head-and-neck-tumor-classification
#7
EDITORIAL
Adel K El-Naggar
No abstract text is available yet for this article.
June 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28258915/resurrection-of-whole-liver-radiotherapy-a-case-report
#8
Sabeena Choudhary, Swarupa Mitra, Manoj Kumar Sharma, Pooja Khullar, Upasna Saxena
This is a case report of a patient of lymphoma with liver metastasis who had persistent pain and jaundice despite multiple lines of chemotherapy. She underwent palliative liver irradiation. This is an uncommon modality due to fear of radiation induced hepatitis. We reviewed literature available on the use of liver irradiation for palliation and concluded that it can be safely used with good results. A 33-year-old female with Non-Hodgkin's Lymphoma (NHL) presented with obstructive jaundice. She underwent stenting followed by chemotherapy...
June 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28462851/editor-s-perspective-how-rare-is-rare
#9
EDITORIAL
Emad Shash
No abstract text is available yet for this article.
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28462850/epstein-barr-virus-infection-and-breast-invasive-ductal-carcinoma-in-egyptian-women-a-single-center-experience
#10
Noha Ed Hassab El-Naby, Hameda Hassan Mohamed, Asmaa Mohamed Goda, Ahmed El Sayed Mohamed
BACKGROUND: A controversy of the role of Epstein-Barr virus (EBV) infection in breast carcinomas has been reported in the literature. OBJECTIVES: We carried on this research to explore possible association between EBV infection and breast invasive ductal carcinoma (IDC) in Egyptian women attending our center. STUDY DESIGN: This study carried out at Sohag university hospital on 84 paraffin embedded samples of breast tissue, of them 42 breast IDC as the case group and 42 breast fibroadenomas as the control group...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28462849/the-profile-of-extremity-and-trunk-soft-tissue-sarcoma-in-a-tertiary-referral-center
#11
Ahmed Mostafa Ahmed Mahmoud, Mohammed Mahmoud, Ahmed Charaf, Manar Mohamed Moneer
BACKGROUND: Proper surgery with adequate safety margin and adjuvant radiotherapy is the main line of treatment of extremity and trunk soft tissue sarcoma (STS). In spite of improved management, the long term follow up is still not satisfactory. OBJECTIVE: To evaluate long term outcome of STS of extremities and trunk regarding adequacy of resection, recurrence and survival. PATIENTS AND METHODS: This prospective study included 25 patients with STS involving extremity and trunk...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28462848/outcome-of-resectable-pediatric-ewing-sarcoma-of-the-ribs
#12
Gehad Ahmed, Manal Zamzam, Mohamed S Zaghloul, Ahmed Kamel, Ranin Soliman, Iman Zaky, Asmaa Salama, Nehal Kamal, Maged ElShafiey
PURPOSE: Was to evaluate the outcome of multimodality treatment in resectable primary Ewing sarcoma/primitive neuroectodermal tumor ES/PNET of the ribs and role of thoracoscopy in facilitating resection of these tumors. PATIENTS AND METHODS: This was a retrospective study including 22 patients with primary ES/PNET of the ribs surgically treated at Children's Cancer Hospital Egypt (CCHE) between January 2008 until the end of December 2014. RESULTS: Median age was 8...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28462847/breaking-the-ritual-metabolic-cycle-in-order-to-save-acetyl-coa-a-potential-role-for-mitochondrial-humanin-in-t2-bladder-cancer-aggressiveness
#13
Nesreen Nabil Omar, Reham Fathy Tash, Youssef Shoukry, Karim Omar ElSaeed
INTRODUCTION: Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis. Reduced mitochondrial respiration and accumulation of mitochondrial genome mutations are among metabolic transformations in this regard. Mitochondrial humanin (MT-RNR2) is a small peptide with anti-apoptotic activities attributed to binding some pro-apoptotic proteins. AIM OF THE WORK: The current study aims at investigating the expression of mitochondrial humanin in bladder tumor cells and the possible casting of humanin anti-apoptotic action through orchestrating some of the mitochondrial metabolic enzymes...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28284768/vulvar-cancer-in-tunisia-epidemiological-and-clinicopathological-features-multicentric-study
#14
Mehdi Kehila, Souad Harabi, Raoudha Mhiri, Omar Touhami, Hassine Saber Abouda, Abdeljalil Khlifi, Mohamed Hsairi, Dalenda Chelli, Mohamed Derbel, Sahbi Kebaili, Nadia Boujelbane, Kais Chaabene, Mohamed Badis Chanoufi
OBJECTIVE: To describe for the first time the epidemiologic and clinico-pathologic characteristics of vulvar cancer in Tunisia. DESIGN: Two parts are distinguished in this study: Part1: Multicentric retrospective study about the characteristics of all cancer cases diagnosed during a 17-years period (January 1998-December 2014) in three departments of Gynecology and Obstetrics: one in south Tunisia and two in the capital. Part 2: To determine the Incidence trend of invasive vulvar cancer in North Tunisia 1994-2009, on the basis of North Cancer Registry of Tunisia...
March 8, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28268056/the-role-of-thoracodorsal-artery-perforator-flap-in-oncoplastic-breast-surgery
#15
Ayman A Amin, Mohamed Rifaat, Ahmed Farahat, Tarek Hashem
BACKGROUND AND AIM: Thoracodorsal artery perforator flap (TDAP) is one of the relatively new techniques in breast reconstruction. In this study, we try to evaluate the outcome of this flap in oncoplastic procedures. METHODS: This study included 40 patients of stage II breast cancer who underwent partial mastectomy with skin excision at the National Cancer Institute of Cairo University between 2011 and 2014. The resultant defects were immediately reconstructed using the thoracodorsal artery perforator flap...
March 3, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28343538/accelerated-hypofractionated-adjuvant-whole-breast-radiation-with-simultaneous-integrated-boost-using-volumetric-modulated-arc-therapy-for-early-breast-cancer-a-phase-i-ii-dosimetric-and-clinical-feasibility-study-from-a-tertiary-cancer-care-centre-of-india
#16
Dodul Mondal, Pramod Kumar Julka, Daya Nand Sharma, Manisha Jana, Macharla Anjaneyelu Laviraj, Suryanarayan Vs Deo, Soumyajit Roy, Randeep Guleria, Goura K Rath
BACKGROUND: Hypofractionation has become standard of care after Breast Conserving Therapy (BCT) in many European and few others western countries. Though still debatable, tumor cavity boost is routinely practised in our centre. Hypofractionation is not yet the current standard of practice in Asian countries. Employing hypofractionation and simultaneous integrated boost to lumpectomy cavity with conformal technique is not the current practice in this region. Hence the study was performed to see whether accelerated hypofractionation and simultaneous boost can be combined using volumetric modulated arc therapy (VMAT) in treating early breast cancer (EBC) patients...
March 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28259631/prognostic-significance-of-epithelial-stromal-caveolin-1-expression-in-prostatic-hyperplasia-high-grade-prostatic-intraepithelial-hyperplasia-and-prostatic-carcinoma-and-its-correlation-with-microvessel-density
#17
Dareen A Mohammed, Duaa S Helal
Caveolin-1 may play a role in cancer development and progression. The aim was to record the expression and localization of caveolin-1 in benign prostatic hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic carcinoma (PCa). Microvessel density was evaluated with CD34 immunostain. Correlations with known prognostic factors of PCa were recorded. Immunohistochemical expression of caveolin-1 and the MVD was evaluated in 65 cases; BPH (25), HGPIN (20) and PCa (20). Stromal caveolin-1expression was significantly higher in BPH than HGPIN and PCca...
March 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28258917/spectrum-of-fungal-infection-in-head-and-neck-cancer-patients-on-chemoradiotherapy
#18
Gunjesh Kumar Singh, Malini R Capoor, Deepthi Nair, K T Bhowmik
BACKGROUND: Radiotherapy for head and neck cancers (HNC) causes alteration of oral mucosal barrier predisposing it to colonization and infection. Such infections often result in pain and burning sensation thus contributing to major morbidity. OBJECTIVE: MATERIALS AND METHODS: Study was done on 50 patients of HNC treated with concurrent chemoradiotherapy. Three samples (throat, urine, blood) were collected for fungal culture and sensitivity. These samples were collected before the start of radiotherapy, during radiotherapy (2nd and 6th week) and post radiotherapy (10th week)...
March 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28258914/gene-expression-profiling-of-circulating-cd133-cells-of-hepatocellular-carcinoma-patients-associated-with-hcv-infection
#19
Abdel-Rahman N Zekri, Enas R El-Sisi, Zeinab F Abdallah, Alaa Ismail, Ahmed Barakat Barakat
AIM: Identifying the genetic expression profile of CD133(+) cells from HCC patients compared to CD133(+) cells from healthy volunteers that may contribute in hepatocarcinogenesis process. METHOD: Circulating CD133(+) cells were sorted from the peripheral blood of HCC patients as well as from healthy volunteers using magnetic activated cell sorting. The differential expression profile of stem cell related genes was performed using the Stem Cell PCR profiling assay...
March 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28258912/risk-stratification-and-pattern-of-cardiotoxicity-in-pediatric-ewing-sarcoma
#20
Emad Moussa, Manal Zamzam, Ahmed Kamel, Zeinab Salah, Iman Attia, Lina Gaber, Ranin Soliman, Sameera Ezzat
INTRODUCTION: Anthracycline chemotherapy contributes to improved outcomes in Ewing sarcoma; however, the most feared complication is cardiotoxicity. Echocardiograms were routinely used to monitor cardiac function after anthracycline treatment. Nevertheless, indices chosen to assess cardiac toxicity vary significantly among different centers, and no uniform protocol has been accepted as ideal. METHODS: This retrospective study included children with Ewing sarcoma treated at Children's Cancer Hospital Egypt over 4years...
March 2017: Journal of the Egyptian National Cancer Institute
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