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Free Radical Research

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https://www.readbyqxmd.com/read/28095729/impact-of-reactive-oxygen-species-generation-on-helicobacter-pylori-related-extragastric-diseases-a-hypothesis
#1
Jannis Kountouras, Marina Boziki, Stergios A Polyzos, Panagiotis Katsinelos, Emmanouel Gavalas, Christos Zeglinas, Dimitri Tzivras, Iordanis Romiopoulos, Nikolaos Giorgakis, Kyriaki Anastasiadou, Elizabeth Vardaka, Constantinos Kountouras, Evangelos Kazakos, Georgia Xiromerisiou, Efthimios Dardiotis, Georgia Deretzi
Helicobacter pylori (H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety of H. pylori-related gastric diseases, as shown in animal and human studies. Helicobacter pylori infection is also associated with variety of systemic extragastric diseases in which H. pylori-related ROS production might also be involved in the pathogenesis of these systemic conditions. We proposed that Hp-related ROS may play a crucial role in the pathophysiology of Hp-related systemic diseases including Alzheimer's disease, multiple sclerosis, glaucoma and other relative neurodegenerative diseases, thereby suggesting introduction of relative ROS scavengers as therapeutic strategies against these diseases which are among the leading causes of disability and are associated with a large public health global burden...
January 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28090786/inorganic-nitrite-modulates-mirna-signatures-in-acute-myocardial-in-vivo-ischemia-reperfusion
#2
Ulrike B Hendgen-Cotta, Daniel Messiha, Sonja Esfeld, René Deenen, Tienush Rassaf, Matthias Totzeck
Acute myocardial infarction is the leading cause of mortality in the industrialized world. While it is essential to attempt an early reperfusion of ischemic myocardial territories, reperfusion itself adds damage to the heart, the ischemia-reperfusion (I/R) injury. Particularly the injury resulting from the very first minutes of reperfusion remains incompletely understood. MicroRNAs (miRNAs) are dynamic regulators in I/R injury. Nitric oxide (•NO) signaling, in turn, interacts with miRNA signaling. Our previous investigations showed that •NO signaling in I/R could be modulated by nitrite...
January 16, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28090788/selection-of-suitable-reference-genes-for-quantitative-real-time-pcr-in-trabecular-meshwork-cells-under-oxidative-stress
#3
Jing Zhao, HongYan Zhou, Lixia Sun, Ben Yang, Lin Zhang, Hongfeng Shi, Yajuan Zheng
Oxidative stress-induced dysfunction in trabecular meshwork (TM) cells is considered a major alteration that can lead to glaucoma. H2O2 is the most widely used agent for inducing oxidation in TM cells in vitro. Quantitative real-time PCR (qPCR) is an important method for studying alterations in gene expression, and suitable (i.e., invariant) reference genes must be defined to normalize expression levels. In this study, eight common reference genes, i.e., PRS18, ACTB, B2M, GAPDH, PPIA, HPRT1, YWHAZ, and TBP, were evaluated for use in studies of H2O2-induced dysfunction in TM cells...
January 15, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28081640/xct-deficiency-aggravates-acetaminophen-induced-hepatotoxicity-under-inhibition-of-the-transsulfuration-pathway
#4
Eun Sil Kang, Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Sho Kobayashi, Atsunori Nabeshima, Sohsuke Yamada, Han Geuk Seo, Satoshi Miyata, Hideyo Sato, Junichi Fujii
Cystine, an oxidized form of cysteine (Cys), is imported into cells via the protein xCT, which is also associated with the export of glutamate as the counter amino acid. In the current study, we attempted to rationalize roles of xCT in the livers of male mice. While xCT was not expressed in the livers of ordinary mice, it was induced under conditions of glutathione depletion, caused by the administration of acetaminophen (AAP). To differentiate the role between xCT and the transsulfuration pathway on the supply of Cys, we employed an inhibitor of the enzyme cystathionine γ-lyase, propargylglycine (PPG)...
January 12, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28074659/ferulic-acid-fa-abrogates-%C3%AE-radiation-induced-oxidative-stress-and-dna-damage-by-up-regulating-nuclear-translocation-of-nrf2-and-activation-of-nhej-pathway
#5
Ujjal Das, Krishnendu Manna, Amitava Khan, Mahuya Sinha, Sushobhan Biswas, Aaveri Sengupta, Anindita Chakraborty, Sanjit Dey
The present study was aimed to evaluate the radioprotective effect of ferulic acid (FA), a naturally occurring plant flavonoid in terms of DNA damage and damage related alterations of repair pathways by gamma radiation. FA was administered at a dose of 50 mg/kg body weight for five consecutive days prior to exposing the swiss albino mice to a single dose of 10 Gy gamma radiation. Ionising radiation induces oxidative damage manifested by decreased expression of Cu, Zn-SOD (SOD stands for super oxide dismutase), Mn-SOD and catalase...
January 11, 2017: Free Radical Research
https://www.readbyqxmd.com/read/27866421/the-development-of-1-3-diphenylisobenzofuran-as-a-highly-selective-probe-for-the-detection-and-quantitative-determination-of-hydrogen-peroxide
#6
Krzysztof Żamojć, Magdalena Zdrowowicz, Paweł Błażej Rudnicki-Velasquez, Karol Krzymiński, Bartłomiej Zaborowski, Paweł Niedziałkowski, Dagmara Jacewicz, Lech Chmurzyński
1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species (ROS) such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals. Under the action of these individuals DPBF has been rapidly transformed to 1,2-dibenzoylbenzene (DBB)...
December 13, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27838938/methionine-sulfoxide-reductase-b1-deficiency-does-not-increase-high-fat-diet-induced-insulin-resistance-in-mice
#7
Jung-Yoon Heo, Hye-Na Cha, Ki Young Kim, Eujin Lee, Suk-Jeong Kim, Yong-Woon Kim, Jong-Yeon Kim, In-Kyu Lee, Vadim N Gladyshev, Hwa-Young Kim, So-Young Park
Methionine-S-sulfoxide reductase (MsrA) protects against high-fat diet-induced insulin resistance due to its antioxidant effects. To determine whether its counterpart, methionine-R-sulfoxide reductase (MsrB) has similar effects, we compared MsrB1 knockout and wild-type mice using a hyperinsulinemic-euglycemic clamp technique. High-fat feeding for eight weeks increased body weights, fat masses, and plasma levels of glucose, insulin, and triglycerides to similar extents in wild-type and MsrB1 knockout mice. Intraperitoneal glucose tolerance test showed no difference in blood glucose levels between the two genotypes after eight weeks on the high-fat diet...
December 9, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27931128/antioxidant-activities-of-ginsenoside-rg1-against-cisplatin-induced-hepatic-injury-through-nrf2-signaling-pathway-in-mice
#8
Yan Gao, Shifeng Chu, Qianhang Shao, Meijin Zhang, Congyuan Xia, Yingying Wang, Yueting Li, Yuxia Lou, Huiyong Huang, Naihong Chen
Oxidative stress is mainly caused by reactive oxygen species (ROS). The damage causes a net stress on normal organs, leading to a gradual loss of vital physiological function. ROS, such as free radicals, represent a class of molecules which are derived from the metabolism of oxygen and exist inherently. However, excessive produced ROS can damage all aerobic organisms. Ginseng is one of the most commonly used alternative herbal medicines, also as a traditional Chinese medicine. The aim of this study is to investigate the antioxidant potential function of ginsenoside Rg1 against cisplatin-caused hepatic damage...
December 8, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27919172/influence-of-glyco-oxidation-on-complexes-between-fibrin-ogen-and-insulin-like-growth-factor-binding-protein-1-in-patients-with-diabetes-mellitus-type-2
#9
Nikola Gligorijević, Ana Penezić, Olgica Nedić
Fibrinogen and insulin-like growth factor-binding protein (IGFBP-1) are tightly connected to metabolic changes and complications in patients with diabetes mellitus (DM), and since they mutually interact to form complexes in plasma, we investigated whether and to what extent IGFBP-1/fibrinogen complexes change due to glyco-oxidative processes in DM and whether they participate in fibrin clot formation. These complexes were determined by immunoblotting in plasma samples from healthy adults and patients with DM type 2...
December 5, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27817252/investigation-of-scavenging-activities-and-distribution-of-paramagnetic-species-in-zanthoxylum-limonella-seeds
#10
Kouichi Nakagawa, Apichet Promjareet, Aroonsri Priprem, Vassana Netweera, Hideyuki Hara
We investigated the scavenging activities of methanol-extracted oil and the distribution of paramagnetic species in Zanthoxylum limonella (ZL) seeds using noninvasive 9 GHz electron paramagnetic resonance (EPR) imaging and continuous wave EPR. EPR detected three different stable paramagnetic species that were assigned to stable organic radicals, Mn(2+), and other paramagnetic metal complexes. Two-dimensional EPR imaging showed that the stable paramagnetic species were located in the pigmented seed region with a strong intensity...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27785947/increased-non-protein-bound-iron-in-down-syndrome-contribution-to-lipid-peroxidation-and-cognitive-decline
#11
Caterina Manna, Arbace Officioso, Francesca Trojsi, Gioacchino Tedeschi, Silvia Leoncini, Cinzia Signorini, Lucia Ciccoli, Claudio De Felice
Down syndrome (DS, trisomy 21) is the leading cause of chromosomal-related intellectual disability. At an early age, adults with DS develop with the neuropathological hallmarks of Alzheimer's disease, associated with a chronic oxidative stress. To investigate if non-protein bound iron (NPBI) can contribute to building up a pro-oxidative microenvironment, we evaluated NPBI in both plasma and erythrocytes from DS and age-matched controls, together with in vivo markers of lipid peroxidation (F2-isoprostanes, F2-dihomo-isoprostanes, F4-neuroprostanes) and in vitro reactive oxygen species (ROS) formation in erythrocytes...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27780373/p62-sqstm1-is-required-for-the-protection-against-endoplasmic-reticulum-stress-induced-apoptotic-cell-death
#12
Jeong Su Park, Sue Young Oh, Da Hyun Lee, Yu Seol Lee, Su Haeng Sung, Hye Won Ji, Moon Joo Lee, Yong-Ho Lee, Sue Goo Rhee, Soo Han Bae
Endoplasmic reticulum (ER) stress is triggered by various cellular stresses that disturb protein folding or calcium homeostasis in the ER. To cope with these stresses, ER stress activates the unfolded protein response (UPR) pathway, but unresolved ER stress induces reactive oxygen species (ROS) accumulation leading to apoptotic cell death. However, the mechanisms that underlie protection from ER stress-induced cell death are not clearly defined. The nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway plays a crucial role in the protection of cells against ROS-mediated oxidative damage...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27778515/characterization-of-titanium-dioxide-nanoparticles-modified-with-polyacrylic-acid-and-h2o2-for-use-as-a-novel-radiosensitizer
#13
Kenta Morita, Serika Miyazaki, Chiya Numako, Shinya Ikeno, Ryohei Sasaki, Yuya Nishimura, Chiaki Ogino, Akihiko Kondo
An induction of polyacrylic acid-modified titanium dioxide with hydrogen peroxide nanoparticles (PAA-TiO2/H2O2 NPs) to a tumor exerted a therapeutic enhancement of X-ray irradiation in our previous study. To understand the mechanism of the radiosensitizing effect of PAA-TiO2/H2O2 NPs, analytical observations that included DLS, FE-SEM, FT-IR, XAFS, and Raman spectrometry were performed. In addition, highly reactive oxygen species (hROS) which PAA-TiO2/H2O2 NPs produced with X-ray irradiation were quantified by using a chemiluminescence method and a EPR spin-trapping method...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27776459/plant-sterol-enriched-soy-milk-consumption-modulates-5-lipoxygenase-12-lipoxygenase-and-myeloperoxidase-activities-in-healthy-adults-a-randomized-controlled-trial
#14
Xing Lin Ho, Jonathan Jia He Liu, Wai Mun Loke
A randomized, double blind, placebo-controlled and crossover study was conducted to simultaneously measure the effects, after 3-h and 4-week daily exposure to plant sterols-enriched food product, on inflammation, oxidative status, 5-lipoxygenase, 12-lipoxygenase, and myeloperoxidase activities in healthy adults. Eighteen healthy participants (67% female, 35.3 (mean) ± 9.5 (SD) years, mean body mass index 22.8 kg m(-2)) received two soy milk (20g) treatments daily: placebo and one containing 2.0 g free plant sterols equivalent of their palmitates (β-sitosterol, 55%; campesterol, 29%; stigmasterol, 23%)...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27776433/inhibition-of-the-heme-induced-hemolysis-of-red-blood-cells-by-thechlorite-based-drug-wf10
#15
J Flemmig, D Schlorke, F-W Kühne, J Arnhold
Excessive release of hemoglobin from red blood cells markedly disturbs the health status of patients due to cytotoxic effects of free hemoglobin and heme. The latter component is able to initiate novel hemolytic events in unperturbed red blood cells. We modeled this process by incubation of ferric protoporphyrin IX with freshly isolated red blood cells from healthy volunteers. The heme-induced hemolysis was inhibited in a concentration-dependent manner by the chlorite-based drug WF10, whereby the hemolysis degree was totally abolished at a molar ratio of 1:2 between chlorite and heme...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27750456/f2-isoprostanes-in-hdl-are-bound-to-neutral-lipids-and-phospholipids
#16
Julie M Proudfoot, Anne E Barden, Kevin D Croft, Jean-Marie Galano, Thierry Durand, Valérie Bultel-Poncé, Martin Giera, Trevor A Mori
Low HDL cholesterol (HDL-C) is a risk factor for coronary artery disease (CAD). However, interventions that raise HDL-C have failed to reduce cardiovascular events. We previously reported that HDL is the main carrier of plasma F2-isoprostanes (F2-IsoPs) that are markers of oxidative stress formed upon oxidation of arachidonic acid. F2-IsoPs are predominantly associated with phospholipids. However, there is evidence that F2-IsoPs in the liver of rats treated with carbon tetrachloride associate with the neutral lipids...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27733076/free-radical-reactions-of-isoxazole-and-pyrazole-derivatives-of-hispolon-kinetics-correlated-with-molecular-descriptors
#17
Shaukat Ali M Shaikh, Atanu Barik, Beena G Singh, Ramani V Modukuri, Neduri V Balaji, Gottumukkala V Subbaraju, Devidas B Naik, K Indira Priyadarsini
Hispolon (HS), a natural polyphenol found in medicinal mushrooms, and its isoxazole (HI) and pyrazole (HP) derivatives have been examined for free radical reactions and in vitro antioxidant activity. Reaction of these compounds with one-electron oxidant, azide radicals ([Formula: see text]) and trichloromethyl peroxyl radicals ([Formula: see text]), model peroxyl radicals, studied by nanosecond pulse radiolysis technique, indicated formation of phenoxyl radicals absorbing at 420 nm with half life of few hundred microseconds (μs)...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27733068/elucidating-the-role-of-oxidative-stress-in-the-therapeutic-effect-of-rutin-on-experimental-acute-pancreatitis
#18
Fabíula Francisca Abreu, Ana Carla Araújo Souza, Simone Aparecida Teixeira, Antônio Garcia Soares, Daiane Franco Teixeira, Rosilene Calazans Soares, Marilia Trindade Santana, Sandra Lauton Santos, Soraia Kátia Pereira Costa, Marcelo Nicolas Muscará, Enilton Aparecido Camargo
INTRODUCTION: Acute pancreatitis (AP) may be severe and cause hospitalization or death, and the available treatment is insufficient to control pancreatic inflammation and pain. Rutin is a natural flavonoid with the potential to treat AP via anti-inflammatory, antinociceptive, and antioxidant activities. AIM: This study investigated the beneficial effects of rutin on experimental AP induced by l-arginine administration in mice. METHODS: The l-arginine-induced AP model was used in Swiss mice (n = 6-8)...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27701922/myeloperoxidase-deficiency-enhances-zymosan-phagocytosis-associated-with-up-regulation-of-surface-expression-of-cd11b-in-mouse-neutrophils
#19
Kenta Fujimoto, Takehiro Motowaki, Naoya Tamura, Yasuaki Aratani
Myeloperoxidase (MPO), a major component of neutrophils, catalyzes the production of hypochlorous acid (HOCl) from hydrogen peroxide and chloride anion. Phagocytosis is a critical event induced by neutrophils for host defense and inflammation. Interestingly, we found that MPO-deficient (MPO(-/-)) neutrophils engulfed larger amounts of zymosan than wild-type neutrophils. Blocking of the CD11b subunit of complement receptor 3 (CR3) as well as inhibition of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) dramatically reduced zymosan phagocytosis...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27677384/interactions-between-peroxiredoxin-2-hemichrome-and-the-erythrocyte-membrane
#20
Simone B Bayer, Felicia M Low, Mark B Hampton, Christine C Winterbourn
Peroxiredoxin 2 (Prx2) is an abundant antioxidant protein in erythrocytes that protects against hemolytic anemia resulting from hemoglobin oxidation and Heinz body formation. A small fraction of Prx2 is bound to the cell membrane, but the mechanism and relevance of binding are not clear. We have investigated Prx2 interactions with the erythrocyte membrane and oxidized hemoglobin and whether these interactions are dependent on Prx2 redox state. Membrane binding of Prx2 in erythrocytes decreased when the cells were treated with H2O2, but studies with purified Prx2 and isolated ghosts showed that the interaction was independent of Prx2 redox state...
December 2016: Free Radical Research
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