journal
MENU ▼
Read by QxMD icon Read
search

Free Radical Research

journal
https://www.readbyqxmd.com/read/27866421/the-development-of-1-3-diphenylisobenzofuran-as-a-highly-selective-probe-for-the-detection-and-quantitative-determination-of-hydrogen-peroxide
#1
Krzysztof Żamojć, Magdalena Zdrowowicz, Paweł Błażej Rudnicki-Velasquez, Karol Krzymiński, Bartłomiej Zaborowski, Paweł Niedziałkowski, Dagmara Jacewicz, Lech Chmurzyński
1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals. Under the action of these individuals DPBF has been rapidly transformed to 1,2-dibenzoylbenzene...
November 20, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27838938/methionine-sulfoxide-reductase-b1-deficiency-does-not-increase-high-fat-diet-induced-insulin-resistance-in-mice
#2
Jung-Yoon Heo, Hye-Na Cha, Ki Young Kim, Eujin Lee, Suk-Jeong Kim, Yong-Woon Kim, Jong-Yeon Kim, In-Kyu Lee, Vadim N Gladyshev, Hwa-Young Kim, So-Young Park
Methionine-S-sulfoxide reductase (MsrA) protects against high-fat diet-induced insulin resistance due to its antioxidant effects. To determine whether its counterpart, methionine-R-sulfoxide reductase (MsrB) has similar effects, we compared MsrB1 knockout and wild-type mice using a hyperinsulinemic-euglycemic clamp technique. High-fat feeding for 8 weeks increased body weights, fat masses, and plasma levels of glucose, insulin, and triglycerides to similar extents in wild-type and MsrB1 knockout mice. Intraperitoneal glucose tolerance test showed no difference in blood glucose levels between the two genotypes after 8 weeks on the high-fat diet...
November 13, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27817252/investigation-of-scavenging-activities-and-distribution-of-paramagnetic-species-in-zanthoxylum-limonella-seeds
#3
Kouichi Nakagawa, Apichet Promjareet, Aroonsri Priprem, Vassana Netweera, Hideyuki Hara
We investigated the scavenging activities of methanol-extracted oil and the distribution of paramagnetic species in Zanthoxylum limonella (ZL) seeds using non-invasive 9 GHz electron paramagnetic resonance (EPR) imaging and continuous wave (CW) EPR. EPR detected three different stable paramagnetic species that were assigned to stable organic radicals, Mn(2+), and other paramagnetic metal complexes. Two-dimensional EPR imaging showed that the stable paramagnetic species were located in the pigmented seed region with a strong intensity...
November 6, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27806645/oxidative-radical-cyclizations-of-diketopiperazines-bearing-an-amidomalonate-unit-heterointermediate-reaction-sequences-toward-the-asperparalines-and-stephacidins
#4
Tynchtyk Amatov, Martin Gebauer, Radek Pohl, Ivana Cisařová, Ullrich Jahn
A novel approach to the diazabicyclo[2.2.2]octane core of prenylated bridged diketopiperazine alkaloids is described by direct oxidative cyclizations of functionalized diketopiperazines mediated by ferrocenium hexafluorophosphate or the Mn(OAc)3•2H2O/Cu(OTf)2 system. Divergent reaction pathways take place depending on the substitution pattern of the substrates and the oxidation conditions such as temperature or the presence or absence of persistent radical TEMPO. For ester-substituted diketopiperazines, the ester group exerts a significant influence on the reaction outcome and stereochemistry of the radical cyclizations...
November 2, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27667096/quantitation-of-plasma-thiamine-related-metabolites-and-plasma-protein-oxidative-damage-markers-in-children-with-autism-spectrum-disorder-and-healthy-controls
#5
Attia Anwar, Marina Marini, Provvidenza Maria Abruzzo, Alessandra Bolotta, Alessandro Ghezzo, Paola Visconti, Paul J Thornalley, Naila Rabbani
AIMS/HYPOTHESIS: To assess thiamine and related metabolite status by analysis of plasma and urine in autistic children and healthy controls, correlations to clinical characteristics and link to plasma protein markers of oxidative damage. METHODS: 27 children with autism (21 males and 6 females) and 21 (15 males and 6 females) age-matched healthy control children were recruited. The concentration of thiamine and related phosphorylated metabolites in plasma and urine and plasma protein content of dityrosine, N-formylkynurenine and 3-nitrotyrosine was determined...
November 2, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27785947/increased-non-protein-bound-iron-in-down-syndrome-contribution-to-lipid-peroxidation-and-cognitive-decline
#6
Caterina Manna, Arbace Officioso, Francesca Trojsi, Gioacchino Tedeschi, Silvia Leoncini, Cinzia Signorini, Lucia Ciccoli, Claudio De Felice
Down syndrome (DS, trisomy 21) is the leading cause of chromosomal-related intellectual disability. At an early age, adults with DS develop with the neuropathological hallmarks of Alzheimer's disease, associated with a chronic oxidative stress. To investigate if non-protein bound iron (NPBI) can contribute to building up a pro-oxidative microenvironment, we evaluated NPBI in both plasma and erythrocytes from DS and age-matched controls, together with in vivo markers of lipid peroxidation (F2-isoprostanes; F2-dihomo-isoprostanes; F4-neuroprostanes) and in vitro reactive oxygen species (ROS) formation in erythrocytes...
October 27, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27780373/p62-sqstm1-is-required-for-the-protection-against-endoplasmic-reticulum-stress-induced-apoptotic-cell-death
#7
Jeong Su Park, Sue Young Oh, Da Hyun Lee, Yu Seol Lee, Su Haeng Sung, Hye Won Ji, Moon Joo Lee, Yong-Ho Lee, Sue Goo Rhee, Soo Han Bae
Endoplasmic reticulum (ER) stress is triggered by various cellular stresses that disturb protein folding or calcium homeostasis in the ER. To cope with these stresses, ER stress activates the unfolded protein response (UPR) pathway, but unresolved ER stress induces reactive oxygen species (ROS) accumulation leading to apoptotic cell death. However, the mechanisms that underlie protection from ER stress-induced cell death are not clearly defined. The nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway plays a crucial role in the protection of cells against ROS-mediated oxidative damage...
October 26, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27778515/characterization-of-titanium-dioxide-nanoparticles-modified-with-polyacrylic-acid-and-h2o2-for-use-as-a-novel-radiosensitizer
#8
Kenta Morita, Serika Miyazaki, Chiya Numako, Shinya Ikeno, Ryohei Sasaki, Yuya Nishimura, Chiaki Ogino, Akihiko Kondo
An induction of polyacrylic acid-modified titanium dioxide with hydrogen peroxide nanoparticles (PAA-TiO2/H2O2 NPs) to a tumor exerted a therapeutic enhancement of X-ray irradiation in our previous study. To understand the mechanism of the radiosensitizing effect of PAA-TiO2/H2O2 NPs, analytical observations that included DLS, FE-SEM, FT-IR, XAFS, and Raman spectrometry were performed. In addition, highly reactive oxygen species (hROS) which PAA-TiO2/H2O2 NPs produced with X-ray irradiation were quantified by using a chemiluminescence method and a EPR spin-trapping method...
October 25, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27776460/the-influence-of-antioxidants-in-the-thiyl-radical-induced-lipid-peroxidation-and-geometrical-isomerization-in-micelles-of-linoleic-acid
#9
Ivana Tartaro Bujak, Branka Mihaljević, Carla Ferreri, Chryssostomos Chatgilialoglu
The biomimetic model of micelles of linoleic acid containing 2-mercaptoethanol and the antioxidant was examined under gamma irradiation up to 400 Gy in aerobic or deoxygenated conditions where thiyl radicals are the main reactive species. Lipid peroxidation was retarded by ascorbic acid and α-tocopherol, whereas this process was strongly inhibited by resveratrol as effectively as the ascorbic acid/α-tocopherol mixture. Furthermore, antioxidants have a much stronger inhibitory effect on the peroxidation in the presence of 2-mercaptoethanol, and at the same time show protective properties of the double bond, decreasing the cis-trans isomerization...
October 25, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27776459/plant-sterol-enriched-soy-milk-consumption-modulates-5-lipoxygenase-12-lipoxygenase-and-myeloperoxidase-activities-in-healthy-adults-a-randomised-controlled-trial-%C3%A2-%C3%A2
#10
Xing Lin Ho, Jonathan Jia He Liu, Wai Mun Loke
A randomized, double blind, placebo-controlled and crossover study was conducted to simultaneously measure the effects, after 3-hour and 4-week daily exposure to plant sterols-enriched food product, on inflammation, oxidative status, 5-lipoxygenase, 12-lipoxygenase and myeloperoxidase activities in healthy adults. Eighteen healthy participants (67% female, 35.3 (mean)±9.5 (SD) years, mean body mass index 22.8 kg m(-2)) received 2 soy milk (20g) treatments daily: placebo and one containing 2.0g free plant sterols equivalent of their palmitates (β-sitosterol, 55%; campesterol, 29% and stigmasterol, 23%)...
October 24, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27776433/inhibition-of-the-heme-induced-hemolysis-of-red-blood-cells-by-the-chlorite-based-drug-wf10
#11
J Flemmig, D Schlorke, F-W Kühne, J Arnhold
Excessive release of hemoglobin from red blood cells markedly disturbs the health status of patients due to cytotoxic effects of free hemoglobin and heme. The latter component is able to initiate novel hemolytic events in unperturbed red blood cells. We modelled this process by incubation of ferric protoporphyrin IX with freshly isolated red blood cells from healthy volunteers. The heme-induced hemolysis was inhibited in a concentration-dependent manner by the chlorite-based drug WF10, whereby the hemolysis degree was totally abolished at a molar ratio of 1: 2 between chlorite and heme...
October 24, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27750460/cost-action-cm1201-biomimetic-radical-chemistry-free-radical-chemistry-successfully-meets-many-disciplines
#12
Carla Ferreri, Bernard T Golding, Ullrich Jahn, Jean-Luc Ravanat
The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for four years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defences, WG4 - Bio-inspired synthetic strategies. International collaborations have been established among the participating 80 research groups with brilliant interdisciplinary achievements. Free radical research with a biomimetic approach has been realized in the COST Action and are summarized in this overview by the four WG leaders...
October 17, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27750456/f2-isoprostanes-in-hdl-are-bound-to-neutral-lipids-and-phospholipids
#13
Julie M Proudfoot, Anne E Barden, Kevin D Croft, Jean-M Galano, Thierry Durand, Valerie Bultel-Ponce, Martin Giera, Trevor A Mori
Low HDL cholesterol (HDL-C) is a risk factor for coronary artery disease (CAD). However, interventions that raise HDL-C have failed to reduce cardiovascular events. We previously reported that HDL is the main carrier of plasma F2-isoprostanes (F2-IsoPs) that are markers of oxidative stress formed upon oxidation of arachidonic acid. F2-IsoPs are predominantly associated with phospholipids. However, there is evidence that F2-IsoPs in the liver of rats treated with carbon tetrachloride associate with the neutral lipids...
October 17, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27733084/radical-induced-purine-lesion-formation-is-dependent-on-dna-helical-topology
#14
Michael A Terzidis, Andreea Prisecaru, Zara Molphy, Niall Barron, Antonio Randazzo, Elise Dumont, Marios G Krokidis, Andrew Kellett, Chryssostomos Chatgilialoglu
Herein we report the quantification of purine lesions arising from gamma-radiation sourced hydroxyl radicals (HO(•)) on tertiary dsDNA helical forms of supercoiled (SC), open circular (OC) and linear (L) conformation, along with single-stranded folded and non-folded sequences of guanine rich DNA in selected G-quadruplex structures. We identify that DNA helical topology and folding plays major, and unexpected, roles in the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and 8-oxo-7,8-dihydro-2'-deoxyadenosine (8-oxo-dA), along with tandem-type purine lesions 5',8-cyclo-2'-deoxyguanosine (5',8-cdG) and 5',8-cyclo-2'-deoxyadenosine (5',8-cdA)...
October 13, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27733076/free-radical-reactions-of-isoxazole-and-pyrazole-derivatives-of-hispolon-kinetics-correlated-with-molecular-descriptors
#15
Shaukat Ali M Shaikh, Atanu Barik, Beena G Singh, Ramani V Madukuri, Neduri V Balaji, Gottumukkal V Subbaraju, Devidas B Naik, K Indira Priyadarsini
Hispolon (HS), a natural polyphenol found in medicinal mushrooms, and its isoxazole (HI) and pyrazole (HP) derivatives have been examined for free radical reactions and in vitro antioxidant activity. Reaction of these compounds with one-electron oxidant, azide radicals (N3(•)) and trichloromethyl peroxyl radicals (CCl3O2(•)), model peroxyl radicals, studied by nanosecond pulse radiolysis technique, indicated formation of phenoxyl radicals absorbing at 420 nm with half life of few hundred microseconds (µs)...
October 13, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27733068/elucidating-the-role-of-oxidative-stress-in-the-therapeutic-effect-of-rutin-on-experimental-acute-pancreatitis
#16
Fabíula Francisca Abreu, Ana Carla Araujó de Souza, Simone Aparecida Teixeira, Antônio Garcia Soares, Daiane Franco Teixeira, Rosilene Calazans Soares, Marilia Trindade Santana, Sandra Lauton Santos, Soraia Kátia Pereira Costa, Marcelo Nicolas Muscará, Enilton Aparecido Camargo
INTRODUCTION: Acute pancreatitis (AP) may be severe and cause hospitalization or death, and the available treatment is insufficient to control pancreatic inflammation and pain. Rutin is a natural flavonoid with the potential to treat AP via anti-inflammatory, antinociceptive and antioxidant activities. AIM: This study investigated the beneficial effects of rutin on experimental AP induced by L-arginine administration in mice. METHODS: The L-arginine-induced AP model was used in Swiss mice (n = 6-8)...
October 13, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27733067/special-issue-for-the-7th-biennial-meeting-of-society-for-free-radical-research-asia-sfrr-asia-2015-thailand
#17
Shinya Toyokuni
No abstract text is available yet for this article.
October 13, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27629563/impact-of-cyanogen-iodide-in-killing-of-escherichia-coli-by-the-lactoperoxidase-hydrogen-peroxide-pseudo-halide-system
#18
D Schlorke, J Atosuo, J Flemmig, E-M Lilius, J Arnhold
In the presence of hydrogen peroxide, the heme protein lactoperoxidase is able to oxidize thiocyanate and iodide to hypothiocyanite, reactive iodine species, and the inter(pseudo)halogen cyanogen iodide. The killing efficiency of these oxidants and of the lactoperoxidase-H2O2-SCN(-)/I(-) system was investigated on the bioluminescent Escherichia coli K12 strain that allows time-resolved determination of cell viability. Among the tested oxidants, cyanogen iodide was most efficient in killing E. coli, followed by reactive iodine species and hypothiocyanite...
October 12, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27629782/roles-of-aldo-keto-reductases-1b10-and-1c3-and-atp-binding-cassette-transporter-in-docetaxel-tolerance
#19
Toshiyuki Matsunaga, Haruhi Saito, Satoshi Endo, Kazuhiro Iguchi, Midori Soda, Ossama El-Kabbani, Akira Hara, Akira Ikari
Docetaxel (DTX) is widely used for treatment of inveterate lung and prostate cancers, but its continuous administration elicits the hyposensitivity. Here, we established the DTX-resistant variants of human lung cancer A549 and androgen-independent prostate cancer Du145 cells and found that the resistance development provoked aberrant up-regulations of aldo-keto reductase (AKR) 1B10 and AKR1C3 in A549 and Du145 cells, respectively. In addition, the sensitivity to the DTX toxicity was significantly decreased and increased by overexpression and knockdown of the two AKR isoforms, respectively...
October 11, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27701922/myeloperoxidase-deficiency-enhances-zymosan-phagocytosis-associated-with-up-regulation-of-surface-expression-of-cd11b-in-mouse-neutrophils
#20
Kenta Fujimoto, Takehiro Motowaki, Naoya Tamura, Yasuaki Aratani
Myeloperoxidase (MPO), a major component of neutrophils, catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride anion. Phagocytosis is a critical event induced by neutrophils for host defense and inflammation. Interestingly, we found that MPO-deficient (MPO(-/-)) neutrophils engulfed larger amounts of zymosan than wild-type neutrophils. Blocking of the CD11b subunit of complement receptor 3 (CR3) as well as inhibition of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) dramatically reduced zymosan phagocytosis...
October 4, 2016: Free Radical Research
journal
journal
31674
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"