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Free Radical Research

Carlo Dani, Chiara Poggi, Simone Pratesi
Hyperbilirubinemia is the most frequent clinical problem neonatologists must deal with during the newborn period. It has been suggested that bilirubin is involved in the balance between antioxidant and pro-oxidant agents due to its antioxidant properties. However, the relevance of these effects in vivo in term and preterm infants is still debated. We performed a literature review of studies that investigated the association between total serum bilirubin (TSB) and oxidative stress in newborn infants. We found that studies in term infants give contradictory results, while studies in preterm infants suggest that the TSB increase is associated with an oxidative stress increase due to concurrent factors other than bilirubin level, such as heme oxygenase (HO) activity...
May 16, 2018: Free Radical Research
Xiaoling Liu, Xinyu Long, Weiwei Liu, Guodong Yao, Yeli Zhao, Toshihiko Hayashi, Shunji Hattori, Hitomi Fujisaki, Takaaki Ogura, Shin-Ichi Tashiro, Satoshi Onodera, Masayuki Yamato, Takashi Ikejima
Reactive oxygen species (ROS) participate in various cell responses in association with cell proliferation, migration, differentiation and death. Extracellular matrix (ECM) serves as cellular microenvironments for many kinds of cells, affecting cell activities. However, whether or not ECM influences cellular ROS levels has not been well studied. In this study, cells are cultured on collagen I molecule-coated (mol. coated) dishes and collagen I fibrous gel-covered (gel) dishes to explore their influence on cell behaviors...
May 16, 2018: Free Radical Research
Mehdi Ahmadian, Valiollah Dabidi Roshan, Anthony S Leicht
The aims of the current study were to investigate the oxidant and antioxidant status of liver tissue challenged by doxorubicin and to examine the possible protective effects of aerobic exercise on doxorubicin-induced oxidative stress. Seventy-two rats were divided into three age groups (Young, Adult, and Elderly) with three treatment subgroups consisting of eight rats per age group: doxorubicin, aerobic exercise + doxorubicin, and aerobic exercise + saline. The experimental groups performed regular treadmill running for 3 weeks...
May 16, 2018: Free Radical Research
Yung-Ting Kuo, Jhong-Huei Jheng, Mei-Chen Lo, Wei-Lu Chen, Shyang-Guang Wang, Horng-Mo Lee
Iron or oxygen regulates the stability of hypoxia inducible factor-1α (HIF-1α). We investigated whether ferrous glycinate would affect HIF-1α accumulation, aerobic glycolysis and mitochondrial energy metabolism in human A549 lung cancer cells. Incubation of A549 cells with ferrous glycinate decreased the protein levels of HIF-1α, which was abrogated by proteosome inhibitor, or prolyl hydroxylase inhibitor. Addition of ferrous glycinate decreased protein levels of glucose transporter-1, hexokinase-2, and lactate dehydrogenase A, and decreased pyruvate dehydrogenase kinase-1 (PDK-1) and pyruvate dehydrogenase (PDH) phosphorylation in A549 cells...
May 15, 2018: Free Radical Research
Alessandra das Graças Fedoce, Frederico Ferreira, Robert G Bota, Vicent Bonet-Costa, Patrick Y Sun, Kelvin J A Davies
Anxiety disorders are the most common mental illness in the USA affecting 18% of the population. The cause(s) of anxiety disorders is/are not completely clear, and research in the neurobiology of anxiety at the molecular level is still rather limited. Although mounting clinical and preclinical evidence now indicates that oxidative stress may be a major component of anxiety pathology, whether oxidative stress is the cause or consequence remains elusive. Studies conducted over the past few years suggest that anxiety disorders may be characterized by lowered antioxidant defenses and increased oxidative damage to proteins, lipids and nucleic acids...
May 9, 2018: Free Radical Research
Giancarlo Aldini, Alessandra Altomare, Giovanna Baron, Giulio Vistoli, Marina Carini, Luisa Borsani, Francesco Sergio
The main molecular mechanisms explaining the well-established antioxidant and reducing activity of N-acetylcysteine (NAC), the N-acetyl derivative of the natural amino acid l-cysteine, are summarised and critically reviewed. The antioxidant effect is due to the ability of NAC to act as a reduced glutathione (GSH) precursor; GSH is a well-known direct antioxidant and a substrate of several antioxidant enzymes. Moreover, in some conditions where a significant depletion of endogenous Cys and GSH occurs, NAC can act as a direct antioxidant for some oxidant species such as NO2 and HOX...
May 9, 2018: Free Radical Research
Wei Wang, Dongdong Chen, Xiaopei Zhang, Liu, Yingying Cheng, Fafu Shen
Plant respiratory burst oxidase homologs (Rbohs), which are also named nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), are the homologs of mammalian phagocyte gp91phox . As a unique among other reactive oxygen species (ROS) production mechanisms in plants, NADPH oxidases can integrate different signal transduction pathways, such as calcium, protein phosphorylation catalyzed by protein kinases, nitric oxide, and lipid messengers. Coupling with genetic studies, the ability of plant NADPH oxidases to integrate different signal transduction pathways with ROS production demonstrates their involvement in many important biological processes in cells, such as morphogenesis and development, and stress responses...
May 7, 2018: Free Radical Research
Li Guo, Yiming Zhao, Dingxin Liu, Zhichao Liu, Chen Chen, Ruobing Xu, Miao Tian, Xiaohua Wang, Hailan Chen, Michael G Kong
Reactive oxygen and nitrogen species (ROS and RNS) generated by cold atmospheric-pressure plasma could damage genomic DNA, although the precise type of these DNA damage induced by plasma are poorly characterized. Understanding plasma-induced DNA damage will help to elucidate the biological effect of plasma and guide the application of plasma in ROS-based therapy. In this study, it was shown that ROS and RNS generated by physical plasma could efficiently induce DNA-protein crosslinks (DPCs) in bacteria, yeast, and human cells...
May 3, 2018: Free Radical Research
Xiaoyu Su, Longfei Xin, Zhuo Li, Huifang Zheng, Jun Mao, Qinghua Yang
To determine the role of melatonin in aging maize seeds ( Zea mays L.), we investigated the physiological characteristics and performance analysis of the transcriptome after applying melatonin to maize seeds as a response to aging. In this study, we demonstrated that applying exogenous melatonin alleviated aging-induced oxidative damage, improved the activity of aging seeds, promoted growth of the germ and radical, enhanced antioxidant enzyme activity and reduced membrane lipid peroxidation. In addition, transcriptome sequencing revealed that various metabolic processes were induced by exogenous melatonin application in aging maize seeds, including hormone signal transduction, cellular processes, carbohydrate metabolism, secondary metabolites, and amino acid metabolism...
May 3, 2018: Free Radical Research
Tomohisa Takagi, Yuji Naito, Makoto Tanaka, Katsura Mizushima, Chihiro Ushiroda, Yuki Toyokawa, Kazuhiko Uchiyama, Masahide Hamaguchi, Osamu Handa, Yoshito Itoh
Recent studies have identified carbon monoxide (CO) as a potential therapeutic molecule for the treatment of inflammatory diseases including intestinal inflammation. In the present study, we explored the efficacy and the mechanisms of action of CO-releasing molecule (CORM)-A1 in T-cell transfer induced colitis model in mice. In addition, the impact of CORM-A1 on the T helper (Th) cell differentiation was evaluated using naïve CD4+ T cells isolated from the spleens in Balb/c mice. The results showed that CORM-A1 conferred protection against the development of intestinal inflammation and attenuated Th17 cell differentiation...
April 26, 2018: Free Radical Research
Marija Pinterić, Iva I Podgorski, Sandra Sobočanec, Marijana Popović Hadžija, Mladen Paradžik, Ana Dekanić, Maja Marinović, Mirna Halasz, Robert Belužić, Grazia Davidović, Andreja Ambriović Ristov, Tihomir Balog
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its role as oncogene or tumour suppressor in different types of cancer. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction and age-related pathologies. Hyperoxic treatment (i.e. generator of ROS) was shown to support some tumourigenic properties, but finally suppresses growth of certain mammary carcinoma cells...
April 23, 2018: Free Radical Research
Chen Hou, Yunhua Peng, Chuan Qin, Fan Fan, Jiankang Liu, Jiangang Long
Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ injection-induced cognitive dysfunction. However, whether and how hydrogen affects AD pathogenesis remains uninvestigated...
April 23, 2018: Free Radical Research
Shinya Akatsuka, Guang Hua Li, Shinya Toyokuni
Evolution of the species and carcinogenesis are similar in that genomic alterations are the key events. Oxidative stress derived from various etiologies is one of the major causes of carcinogenesis by inducing mutations in the genome. Persistent oxidative stress in the renal proximal tubules through Fenton reaction catalyzed by ferric nitrilotriacetate (Fe-NTA) generates renal cell carcinoma (RCC) in mice and rats. Here, in order to observe the species difference in oxidative stress-induced carcinogenesis and to obtain an insight regarding the characteristics of each species, we compared the genomic alterations using array-based comparative genome hybridization among RCCs in Mutyh knockout/wild-type mice (C57BL/6 background) induced by Fe-NTA, RCCs in F1 hybrids of Brown-Norway/Fischer-344 wild-type rats and clear cell renal cell carcinoma (CCRCC)/papillary renal cell carcinoma (PRCC) of humans...
April 18, 2018: Free Radical Research
Beata Jasiewicz, Arleta Sierakowska, Wojciech Jankowski, Marcin Hoffmann, Weronika Piorońska, Agnieszka Górnicka, Anna Bielawska, Krzysztof Bielawski, Lucyna Mrówczyńska
A series of new di- and polyamine-caffeine analogues were synthesized and characterized by NMR, FT-IR and MS spectroscopic methods. To access stability of the investigated caffeine analogues Molecular Dynamic simulations were performed in NAMD 2.9 assuming CHARMM36 force field. To evaluate the antioxidant capacity of new compounds, three different antioxidant assays were used, namely 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH• ) scavenging activity, ferrous ions (Fe2+ ) chelating activity and Fe3+ →Fe2+ reducing ability...
April 18, 2018: Free Radical Research
Soumita De, Sunanda Kundu, Uttara Chatterjee, Subrata Chattopadhyay, Mitali Chatterjee
The cornerstone of treatment for rheumatoid arthritis is low dose methotrexate (MTX), but its use is limited by concerns regarding its potential for hepatotoxicity. Allylpyrocatechol (APC), a phytoconstituent sourced from leaves of Piper betle demonstrated antioxidant, anti-inflammatory and antiarthritic properties. The present study aimed to evaluate the combined effect of APC and MTX on limiting progression of lipopolysaccharide accelerated collagen-induced arthritis, along with reduction of MTX-induced hepatic damage...
April 16, 2018: Free Radical Research
Farjam Goudarzi, Adel Mohammadalipour, Majid Bahabadi, Mohammad Taghi, Goodarzi, Arash Sarveazad, Iraj Khodadadi
Common protocols for chondrogenic differentiation of adipose-derived mesenchymal stem cells (ADSCs) are generally expensive and time-consuming and so far, have not successfully recreated pure chondrocytes. We hypothesize that a low level of H2 O2 may induce differentiation of ADSCs into chondrocytes in a shorter incubation time and relatively lower cost. Therefore, this study aimed to comparatively investigate the effectiveness of H2 O2 -containing or free medium in the induction of ADSCs to chondrocytes. ADSCs were isolated from the lipoaspirate of four healthy females and evaluated by immunophenotyping for their CD90, CD73, CD44, CD34, and CD45 cell surface markers...
April 15, 2018: Free Radical Research
Paulo E da Costa, Wagner L Batista, Miriam S Moraes, Arnold Stern, Hugo P Monteiro
Tumour progression involves the establishment of tumour metastases at distant sites. Resistance to anoikis, a form of cell death that occurs when cells lose contact with the extracellular matrix and with neighbouring cells, is essential for metastases. NO has been associated with anoikis. NO treated HeLa cells and murine melanoma cells in suspension triggered a nitric oxide (NO)-Src kinase signalling circuitry that enabled resistance to anoikis. Two NO donors, sodium nitroprusside (SNP) (500 µM) and DETANO (125 µM), protected against cell death derived from detachment of a growth permissive surface (experimental anoikis)...
April 13, 2018: Free Radical Research
Małgorzata Sztanke, Martyna Kandefer-Szerszeń, Krzysztof Sztanke
Biologically and chemically useful hydrazinoimidazolines were evaluated as antioxidant and antihaemolytic agents. 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH• ), galvinoxyl radical (GOR), nitric oxide (NO) and hydrogen peroxide (H2 O2 ) scavenging assays, ferric ions reducing power assay and ex vivo model of rat erythrocytes exposed to 2,2'-azobis(2-methylpropionamidine)dihydrochloride (AAPH) or H2 O2 were used. The most potent DPPH• scavengers proved to be hydrazinoimidazolines 3, 2 and 4, revealing excellent antiradical effects - superior or comparable to that of all antioxidant standards used...
April 12, 2018: Free Radical Research
Emmanuel Simon, P Aswini, V B Sameer Kumar, Gokuldas Mankadath
Curcumin is a polyphenol derived from the herb Curcuma longa, which has been extensively studied in terms of its antitumour, antioxidant, and chemopreventive activity as well as various other effects. In the present work we compared curcumin with its synthetic analogue dimethoxycurcumin (dimc) in terms of its antioxidant enzyme-modulating effects in human peripheral blood mononuclear cells (PBMC). We found that these compounds modulate antioxidant enzymes differentially. Both curcumin and dimethoxycurcumin effected a decrease in lipid peroxidation status in PBMC, however, curcumin had better activity in this regard...
April 6, 2018: Free Radical Research
Jiajia Shao, Christophe Glorieux, Jianwei Liao, Ping Chen, Wenhua Lu, Zhenhao Liang, Shijun Wen, Yumin Hu, Peng Huang
K-ras is one of the most common oncogenes in human cancers, and its aberrant activation may lead to malignant transformation associated with oxidative stress and activation of the transcription factor Nrf2 that regulates multiple detoxification enzymes. The purpose of this research was to use gene editing technology to evaluate the role of Nrf2 in affecting tumor growth and drug sensitivity of K-rasG12V -transformed cells. We showed that induction of K-rasG12V caused a significant activation of Nrf2 associated with increased expression of its target genes NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1)...
April 5, 2018: Free Radical Research
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