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European Journal of Endocrinology

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https://www.readbyqxmd.com/read/28100632/the-role-of-hepatic-trans-arterial-chemoembolization-in-metastatic-medullary-thyroid-carcinoma-a-specialist-center-experience-and-review-of-the-literature
#1
Simona Grozinsky-Glasberg, Allan Bloom, Naama Lev-Cohain, Alexander Klimov, Hashem Besiso, David Gross
BACKGROUND: Liver metastases are relatively common in patients with metastatic medullary thyroid carcinoma (MTC), carrying a negative impact on disease prognosis. The options for selective therapy of liver metastases in MTC patients are limited to catheter guided procedures such as trans-arterial chemoembolization (TACE). Data regarding the effectiveness and safety of this procedure in MTC is limited. AIM: To explore the clinical outcome, survival and safety profile of TACE for liver metastases in a group of MTC patients...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100631/association-of-triiodothyronine-levels-with-future-development-of-metabolic-syndrome-in-euthyroid-middle-aged-subjects-a-6-year-retrospective-longitudinal-study
#2
Hye Jeong Kim, Ji Cheol Bae, Hyeong Kyu Park, Dong Won Byun, Kyo Il Seo, Myung Hi Yoo, Jae Hwan Jee, Jae Hyeon Kim, Yong-Ki Min, Sun Wook Kim, Jae Hoon Chung
Background Several cross-sectional studies have reported that thyroid hormone levels are associated with cardiovascular risk markers and metabolic syndrome (MetS) even in euthyroid subjects. However, the prognostic role of serum thyroid hormone levels in the risk of incident MetS has not been elucidated. Aim We aimed to investigate the associations of baseline serum thyroid hormone levels with the development of MetS in healthy subjects. Methods This 6-year, cross-sectional, longitudinal and follow-up study was conducted in 12,037 euthyroid middle-aged subjects without MetS subjected to comprehensive health examinations...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100630/a-multivariable-prediction-model-for-pegvisomant-dosing-monotherapy-and-in-combination-with-long-acting-somatostatin-analogues
#3
Sanne Elisabeth Franck, Tim Korevaar, Patrick Petrossians, Adrian F Daly, Philippe Chanson, Marielise Jaffrian-Rea, Thierry Brue, Günter K Stalla, Davide Carvalho, Annamaria Anita Livia Colao, Vasik Hana, Brigitte Delemer, Carmen Fajardo Montañana, A J Van der Lely, Albert Beckers, Sebastian J C M M Neggers
BACKGROUND: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. OBJECTIVE: To identify predictors of the PEGV dose required to normalize insulin-like growth factor I (IGF-I) levels during PEGV monotherapy and in combination with long-acting somatostatin analogues (LA-SSAs)...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100629/impact-of-food-alcohol-and-ph-on-modified-release-hydrocortisone-developed-to-treat-congenital-adrenal-hyperplasia
#4
Nayananjani Karunasena, Daniel Margetson, Greg Neal, Martin Whitaker, Richard J Ross
BACKGROUND: We developed a modified-release hydrocortisone, Chronocort®, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug absorption and it is important to assess their impact when replicating a physiological rhythm. SUBJECTS AND METHODS: In vitro dissolution to study impact of alcohol and pH on Chronocort®. A Phase 1, three-period, cross over study in 18 volunteers to assess the impact of food on Chronocort® and to compare bioavailability to immediate-release hydrocortisone...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100628/external-validation-of-the-great-score-to-predict-relapse-risk-in-graves-disease-results-from-a-multicenter-retrospective-study-with-741-patients
#5
Tristan Struja, Marina Kaeslin, Fabienne Boesiger, Rebecca Jutzi, Noemi Imahorn, Alexander Kutz, Luca Bernasconi, Esther Mundwiler, Beat Mueller, Mirjam Christ-Crain, Fabian Meienberg, Fahim Ebrahimi, Christoph Henzen, Stefan Fischli, Marius Kraenzlin, Christian Meier, Philipp Schuetz
CONTEXT: First line treatment in Graves' disease is often done with antithyroid agents (ATD) but relapse rates remain high making definite treatment necessary. Predictors for relapse risk help guiding initial treatment decisions. OBJECTIVE: We aimed to externally validate the prognostic accuracy of the recently proposed Graves' Recurrent Events After Therapy [GREAT] score to predict relapse risk in Graves` disease. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed data (2004-2014) of patients with a first episode of Graves' hyperthyroidism from four Swiss endocrine outpatient clinics...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28089996/a-comparison-of-lobectomy-and-total-thyroidectomy-for-patients-with-papillary-thyroid-microcarcinoma-a-retrospective-individual-risk-factor-matched-cohort-study
#6
Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Suyeon Park, Mijin Kim, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Tae Yong Kim, Young-Kee Shong, Won Bae Kim
OBJECTIVE: Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in thyroid cancer in recent decades. We compared clinical outcomes and surgical complications of lobectomy and total thyroidectomy (TT) for PTMC patients. DESIGN AND METHODS: In this retrospective individual risk factor matched cohort study, 2031 patients with PTMC were initially included. Patients who underwent lobectomy or TT were one-to-one matched according to individual risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality, and cervical lymph node (LN) metastasis...
January 15, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28077500/distinct-inflammatory-gene-expression-in-extraocular-muscle-and-fat-from-patients-with-graves-orbitopathy
#7
Ivana Lopes Romero-Kusabara, José Vital Filho, Nilza Maria Scalissi, Keli Cardoso Melo, Giovanni Demartino, Carlos Alberto Longui, Murilo Rezende Melo, Adriano Namo Cury
OBJECTIVE: This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the GRα, IKK1, IκB, c-Fos (AP-1), NF-kB, and 11β-HSD1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS: A prospective study design was used to evaluate 34 TED patients and 38 healthy controls. OF was harvested from 33 TED patients and 27 controls. EOM biopsies were obtained from 32 TED patients and 18 controls...
January 11, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28077499/dynamic-gnrh-and-hcg-testing-establishment-of-new-diagnostic-reference-levels
#8
A Kirstine Bang, Loa Nordkap, Kristian Almstrup, Lærke Priskorn, Jørgen Holm Petersen, Ewa Rajpert-De Meyts, Anna-Maria Andersson, Anders Juul, Niels Joergensen
: 1. OBJECTIVE: Gonadotropin-releasing hormone (GnRH) and Human Chorionic Gonadotropin (hCG) stimulation-tests may be used to evaluate the pituitary and testicular capacity. Our aim was to evaluate changes in follicular-stimulating hormone (FSH), luteinizing hormone (LH) and Testosterone after GnRH and hCG stimulation in healthy men, and assess the impact of six single nucleotide polymorphisms on the responses. 2. DESIGN: GnRH- and hCG-stimulation tests were performed on 77 healthy men, 18-40 years (reference group) at a specialized andrology referral center...
January 11, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28077498/modulation-of-shbg-binding-to-testosterone-and-estradiol-by-sex-and-morbid-obesity
#9
Maria Del Mar Grasa, José Gulfo, Núria Camps, Rosa Alcalá, Laura Monserrat, José María Moreno-Navarrete, F Ortega, Montserrat Esteve, Xavier Remesar, José Antonio Fernández-López, José Manuel Fernández-Real, Marià Alemany
OBJECTIVE: Sex hormone-binding globulin (SHBG) binds and transports testosterone and estradiol in plasma. The possibility that SHBG is a mixture of transporting proteins has been postulated. We analyzed in parallel the effects of obesity status on the levels and binding capacity of circulating SHBG and their relationship with testosterone and estradiol. DESIGN: Anthropometric measures and plasma were obtained from apparently healthy young (i.e. 35 ± 7 years) premenopausal women (n=32) and men (n=30), with normal weight and obesity (BMI>30 kg·m(-2))...
January 11, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28077497/bone-material-strength-index-as-measured-by-impact-microindentation-is-altered-in-patients-with-acromegaly
#10
Frank Malgo, Neveen Hamdy, Ton J Rabelink, H Kroon, Kim M J A Claessen, Alberto M Pereira, N R Biermasz, Natasha M Appelman-Dijkstra
OBJECTIVE: Acromegaly is a rare disease caused by excess growth hormone (GH) production by a pituitary adenoma. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of relatively normal Bone Mineral Density (BMD). We aimed to evaluate tissue-level properties of bone using impact microindentation (IMI) in well-controlled patients with acromegaly aged ≥18 years compared to 44 controls from the outpatient clinic of the Centre for Bone Quality...
January 11, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28073908/the-neuroendocrine-sequelae-of-paediatric-craniopharyngioma-a-40-year-meta-data-analysis-of-185-cases-from-three-uk-centres
#11
Timothy Shao Ern Tan, Leena Patel, Jaya Sujatha Gopal-Kothandapani, Sarah Ehtisham, Esieza Clare Ikazoboh, Richard Hayward, Kristian Aquilina, Mars Skae, Nicky Thorp, Barry Pizer, Mohammed Didi, Conor Mallucci, Joanne C Blair, Mark N Gaze, Ian Kamaly-Asl, Helen Spoudeas, Peter E Clayton
Objectives The management of paediatric craniopharyngiomas was traditionally complete resection (CR), with better reported tumour control compared to partial resection (PR) or limited surgery (LS). The subsequent shift towards hypothalamic-sparing, conservative surgery with adjuvant radiotherapy (RT) to any residual tumour, aimed at reducing neuroendocrine morbidity, has not been systematically studied. Hence, we reviewed the sequelae of differing management strategies in paediatric craniopharyngioma across three UK tertiary centres over four decades...
January 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28073907/metformin-prevents-metabolic-side-effects-during-systemic-glucocorticod-treatment
#12
Eleonora Seelig, Stefanie Meyer, Katharina Timper, Nicole Nigro, Martina Bally, Ida Pernicova, Philipp Schuetz, Beat Muller, Marta Korbonits, Mirjam Christ-Crain
Objectives Patients receiving glucocorticoid treatment are prone to develop metabolic complications. In preclinical studies metformin prevented the development of the metabolic syndrome during glucocorticoid excess. We herein investigated the metabolic effect of metformin during glucocorticoid treatment in non-diabetic patients. Methods In a double-blind, placebo-controlled trial, patients starting glucocorticoid treatment (prednisone, prednisolone or methylprednisolone) for four weeks were randomized to concomitantly receive metformin (850mg once daily for one week followed by 850mg twice daily for three weeks) or placebo...
January 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28073906/mri-follow-up-is-unnecessary-in-patients-with-macroprolactinomas-and-long-term-normal-prolactin-levels-on-dopamine-agonist-treatment
#13
Juliette Eroukhmanoff, Isabelle Tejedor, Iulia Potorac, Thomas Cuny, Jean Francois Bonneville, Henry Dufour, Georges Weryha, Albert Beckers, Philippe Touraine, Thierry Brue, Frédéric Castinetti
OBJECTIVE Both antitumor and antisecretory efficacies of dopamine agonists (DA) make them the first line treatment of macroprolactinomas. However, there is no guideline for MRI follow-up once prolactin is controlled. The aim of our study was to determine whether a regular MRI follow-up was necessary in patients with long-term normal prolactin levels under DA. PATIENTS AND METHODS We conducted a retrospective multicenter study (Marseille, Paris La Pitie Salpetriere and Nancy, France; Liege, Belgium) including patients with macroprolactinomas (largest diameter > 10 mm, baseline prolactin level > 100 ng/mL) treated by dopamine agonists, and regularly followed (pituitary MRI and prolactin levels) during at least 48 months once normal prolactin level was obtained...
January 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28007845/cabergoline-for-cushing-s-disease-a-large-retrospective-multicenter-study
#14
Amandine Ferriere, Christine Cortet, Philippe Chanson, Brigitte Delemer, Philippe Caron, Olivier Chabre, Yves Reznik, Jerome Bertherat, Vincent Rohmer, Claire Briet, Isabelle Raingeard, Frédéric Castinetti, Albert Beckers, Laurent Vroonen, Dominique Maiter, Fritzline Cephise-Velayoudom, Marie-Laure Nunes, Magalie Haissaguerre, Antoine Tabarin
OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received carbergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism, and adverse effects were recorded...
December 22, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28007843/clinical-characteristics-and-management-of-growth-hormone-excess-in-patients-with-mccune-albright-syndrome
#15
Yong Yao, Yang Liu, Lin Jie Wang, Kan Deng, Hongbo Yang, Lin Lu, Feng Feng, Bing Xing, Hui You, Zimeng Jin, Renzhi Wang, Hui Pan, Shi Chen, Hui Juan Zhu
OBJECTIVE: McCune-Albright syndrome (MAS) is a sporadic, postzygotic disease presenting with fibrous dysplasia, cafe-au-lait spots and multiple endocrinopathies. Growth hormone (GH) excess is an uncommon but potentially severe complication of MAS. This study aims to describe the clinical manifestations of GH excess in the context of MAS, and analyze the responses of these patients to treatments. DESIGN: Retrospective clinical study. METHODS: Clinical data from 52 MAS patients were analyzed...
December 22, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27932411/mod-4023-a-long-acting-carboxy-terminal-peptide-ctp-modified-human-growth-hormone-results-of-a-phase-2-study-in-growth-hormone-deficient-adults
#16
Christian J Strasburger, Peter Vanuga, Juraj Payer, Marija Pfeifer, Vera Popović, Laszlo Bajnok, Miklós I Góth, Věra Olšovská, Ľudmila Trejbalová, Janos Vadasz, Eyal Fima, Ronit Koren, Leanne Amitzi, Martin Bidlingmaier, Gili Hart, Beverly M K Biller
OBJECTIVE: Growth hormone (GH) replacement therapy currently requires daily injections, which may cause distress and low compliance. C-terminal peptide (CTP)-modified growth hormone (MOD-4023) is being developed as a once-weekly dosing regimen in patients with GH deficiency (GHD). This study's objective is to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of MOD-4023 administered once weekly in GHD adults. DESIGN: 54 adults with GHD currently treated with daily GH were normalized and randomized into 4 weekly dosing cohorts of MOD-4023 at 18...
December 8, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27932409/increased-prevalence-of-obstructive-sleep-apnea-in-patients-with-cushing-s-syndrome-compared-to-weight-and-age-matched-controls
#17
Feyzi Gokosmanoglu, Aygül Güzel, Elif Kilic Kan, Hulusi Atmaca
OBJECTIVE: Diabetes mellitus and obesity are well-known risk factors associated with obstructive sleep apnea(OSA). Cushing's syndrome (CS) is also characterised by obesity and diabetes mellitus. However, the association between CS and OSA remains unclear. Therefore, we investigated the possible associations between CS and OSA in this study. PATIENTS AND METHODS: Thirty female patients with newly diagnosed active CS and 30 age-, gender and body mass index (BMI)-matched female controls were included in this study...
December 8, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28049653/mechanisms-in-endocrinology-diabetes-mellitus-a-state-of-low-bone-turnover-a-systematic-review-and-meta-analysis
#18
REVIEW
Katrine Hygum, Jakob Starup-Linde, Torben Harsløf, Peter Vestergaard, Bente L Langdahl
OBJECTIVE: To investigate the differences in bone turnover between diabetic patients and controls. DESIGN: A systematic review and meta-analysis. METHODS: A literature search was conducted using the databases Medline at PubMed and EMBASE. The free text search terms 'diabetes mellitus' and 'bone turnover', 'sclerostin', 'RANKL', 'osteoprotegerin', 'tartrate-resistant acid' and 'TRAP' were used. Studies were eligible if they investigated bone turnover markers in patients with diabetes compared with controls...
March 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28049652/association-of-adrenal-insufficiency-with-insulin-dependent-diabetes-mellitus-in-a-patient-with-inactivating-mutations-in-nicotinamide-nucleotide-transhydrogenase-a-phenocopy-of-the-animal-model
#19
Rachel Scott, Guy Van Vliet, Johnny Deladoëy
No abstract text is available yet for this article.
March 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28007844/measurement-of-immunofunctional-leptin-to-detect-and-monitor-patients-with-functional-leptin-deficiency
#20
Martin Wabitsch, Lutz Pridzun, Michael Ranke, Julia von Schnurbein, Anja Moss, Stephanie Brandt, Katja Kohlsdorf, Barbara Moepps, Michael Schaab, Jan-Bernd Funcke, Peter Gierschik, Pamela Fischer-Posovszky, Bertram Flehmig, Jürgen Kratzsch
CONTEXT AND AIMS: Functional leptin deficiency is characterized by high levels of circulating immunoreactive leptin (irLep), but a reduced bioactivity of the hormone due to defective receptor binding. As a result of the fact that affected patients can be successfully treated with metreleptin, it was aimed to develop and validate a diagnostic tool to detect functional leptin deficiency. METHODS: An immunoassay capable of recognizing the functionally relevant receptor-binding complex with leptin was developed (bioLep)...
March 2017: European Journal of Endocrinology
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