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European Journal of Endocrinology

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https://www.readbyqxmd.com/read/28325825/very-long-term-sequelae-of-craniopharyngioma
#1
Mark Wijnen, Marry M van den Heuvel-Eibrink, Joseph A M J L Janssen, Coriene E Catsman-Berrevoets, Erna M C Michiels, Marie-Lise C van Veelen-Vincent, Alof H G Dallenga, Jan H van den Berge, Carolien M van Rij, A J Van der Lely, Sebastian J C M M Neggers
OBJECTIVE: Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and do generally not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation...
March 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28325824/persistence-of-myopathy-in-cushing-s-syndrome-evaluation-of-the-german-cushing-s-registry
#2
Christina Maria Berr, Mareike R Stieg, Timo Deutschbein, Marcus Quinkler, Ralf Schmidmaier, Andrea Osswald, Nicole Reisch, Katrin Ritzel, Christina Dimopoulou, Julia Fazel, Stefanie Hahner, Gunter K Stalla, Felix Beuschlein, Martin Reincke
BACKGROUND: Cushing's syndrome (CS) is characterized by an excessive secretion of glucocorticoids that results in a characteristic clinical phenotype. One feature of clinical hypercortisolism is breakdown of protein metabolism translating into clinical consequences including glucocorticoid induced myopathy. While surgery is effective in control of cortisol excess, the effect of biochemical remission on muscular function is yet unclear. METHODS: In a cross-sectional study we analyzed 47 patients with CS during the florid phase (ActiveCS)...
March 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28325823/video-conferences-preceded-by-uploading-of-measurements-as-add-on-to-standard-care-among-patients-with-type-2-diabetes-not-responding-to-standard-regimens-a-randomized-controlled-trial
#3
Caroline Raun Hansen, Hans Perrild, Birgitte Gade Koefoed, Mette Zander
OBJECTIVE: To examine whether video consultations preceded by measurements of blood glucose, weight and blood pressure as add-on to standard care could contribute to achieving and maintaining good diabetes control among patients with poorly regulated type 2 diabetes (T2D). DESIGN: Randomized controlled trial. METHODS: 165 patients with T2D were randomized 1:1 to telemedicine intervention as add-on to clinic based care or control (clinic based care)...
March 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28298353/simultaneous-assay-of-cortisol-and-dexamethasone-improved-diagnostic-accuracy-of-the-dexamethasone-suppression-test
#4
Grethe Åstrøm Ueland, Paal Methlie, Ralf Kellmann, Marit R Bjørgaas, Bjorn O Asvold, Ketil Thorstensen, Oskar Kelp, Hrafnkell B Thordarson, Gunnar Mellgren, Kristian Løvås, Eystein Sverre Husebye
OBJECTIVES: The overnight dexamethasone (DXM)-suppression test (DST) has high sensitivity, but moderate specificity, for diagnosing hypercortisolism. We have evaluated if simultaneous measurement of S-DXM may correct for variable DXM bioavailability and increase diagnostic performance of DST, and if saliva (sa) is a feasible adjunct or alternative to serum. DESIGN AND METHODS: Prospective study of DST in suspected Cushing's syndrome (CS) (n= 49), incidentaloma (n= 152), and controls (n= 101)...
March 15, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28292927/long-term-safety-of-once-daily-dual-release-hydrocortisone-in-patients-with-adrenal-insufficiency-a-phase-3b-open-label-extension-study
#5
Anna G Nilsson, Ragnhildur Bergthorsdottir, Pia Burman, Per Dahlqvist, Bertil Ekman, Britt Edén Engstrom, Oskar Ragnarsson, Stanko Skrtic, Jeanette Wahlberg, Heinrich Achenbach, Sharif Uddin, Claudio Marelli, Gudmundur Johannsson
OBJECTIVE: To investigate the long-term safety and tolerability of a once-daily, dual-release hydrocortisone (DR-HC) tablet as oral glucocorticoid replacement therapy in patients with primary adrenal insufficiency (AI). DESIGN: Prospective, open-label, multicenter, 5-year extension study of DR-HC conducted at five university clinics in Sweden. METHODS: Seventy-one adult patients diagnosed with primary AI who were receiving stable glucocorticoid replacement therapy were recruited...
March 14, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28292926/management-of-endocrine-disease-acromegaly-and-pregnancy-a-contemporary-review
#6
Julio Abucham, M D Bronstein, Monike Lourenço Dias
Although fertility is frequently impaired in women with acromegaly, pregnancy is apparently becoming more common due to improvement in acromegaly treatment as well as in fertility therapy. As a result, several studies on pregnancy in patients with acromegaly have been published in recent years adding new and relevant information to the preexisting literature. Also, new GH assays with selective specificities and the knowledge of the expression of the various GH genes have allowed a better understanding of somatotrophic axis function during pregnancy...
March 14, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28289104/scalp-hair-cortisol-for-diagnosis-of-cushing-s-syndrome
#7
Vincent L Wester, Martin Reincke, Jan Koper, Erica van den Akker, Laura Manenschijn, Christina Maria Berr, Julia Fazel, Yolanda de Rijke, Richard A Feelders, Elisabeth F C van Rossum
OBJECTIVE: Current first-line screening tests for Cushing's syndrome (CS) only measure time-point or short-term cortisol. Hair cortisol content (HCC) offers a non-invasive way to measure long-term cortisol exposure over several months of time. We aimed to evaluate HCC as a screening tool for CS. DESIGN: case-control study in two academic referral centers for CS Methods: Between 2009 and 2016, we collected scalp hair from patients suspected of CS and healthy controls...
March 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28289103/bone-structural-changes-after-gastric-bypass-surgery-evaluated-by-hr-pqct-a-two-year-longitudinal-study
#8
Vikram Vinod Shanbhogue, René Klinkby Støving, Katrine Diemer Frederiksen, Stine Hanson, Kim Brixen, Jeppe Gram, Niklas Rye Jorgensen, Stinus Hansen
Objective, design and methods: Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease. To assess impact on bone mass and structure, we measured areal bone mineral density at the hip and spine by dual-energy x-ray absorptiometry, and volumetric BMD (vBMD) and bone microarchitecture at the distal radius and tibia by high-resolution peripheral quantitative CT in 25 morbidly obese subjects (15 females, 10 males) at 0, 12 and 24 months after RYGB...
March 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28283537/increased-osteoclastogenesis-in-patients-with-vertebral-fractures-following-discontinuation-of-denosumab-treatment
#9
Athanasios D Anastasilakis, Maria P Yavropoulou, Polyzois Makras, Grigorios T Sakellariou, Foteini Papadopoulou, Spyridon Gerou, Socrates Papapoulos
OBJECTIVE: To test the hypothesis that rebound of bone remodeling is responsible for clinical vertebral fractures reported in a few patients with osteoporosis after cessation of denosumab treatment. DESIGN: In this case-control study we compared clinical and biochemical characteristics of postmenopausal women with clinical vertebral fractures 8 to 16 months after the last injection of denosumab (Dmab/Fx+, n=5) with those of treatment-naïve women with such fractures (Fx+, n=5)...
March 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28274950/management-of-endocrine-disease-diagnostic-and-therapeutic-approach-of-tall-stature
#10
Edoarda Vasco de Albuquerque Albuquerque, Renata C Scalco, Alexander Augusto de Lima Jorge
Tall stature is defined as a height of more than 2 standard deviations (SD) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitutional advance of growth (generally associated with obesity), both of which are diagnoses of exclusion. It is necessary to have familiarity with a large number of rarer overgrowth syndromes, especially because some of them may have severe complications such as aortic aneurysm, thromboembolism and tumor predisposition and demand specific follow-up approaches...
March 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28274949/management-of-endocrine-disease-subclinical-thyrotoxicosis-prevalence-causes-and-choice-of-therapy
#11
Allan Carle, Stine Linding Andersen, Kristien Boelaert, Peter Laurberg
Subclinical thyrotoxicosis is a condition affecting up to 10% of the population in some studies. We have reviewed literature and identified studies describing prevalences, causes and outcomes of this condition. Treatment should be considered in all subjects if this biochemical abnormality is persistent, especially in case of symptoms of thyrotoxicosis or in the presence of any complication. In particular, treatment should be offered in those subclinically thyrotoxic patients with a sustained serum TSH below 0...
March 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28264815/mechanisms-in-endocrinology-aging-and-anti-aging-endocrinology-a-combo-overview
#12
Evanthia Diamanti-Kandarakis, Maurizio Datillo, Djuro Macut, Leonidas H Duntas, Efstathios Gonos, Dimitrios Goulis, Christina Kanaka-Gantenbein, Marianna Kapetanou, Eftychia G Koukkou, Irene Lambrinoudaki, Marina Michalaki, Shahla Nader-Eftekhari, Renato Pasquali, Melpomeni Peppa, Marinella Tzanela, Evangeline Vassilatou, Andromachi Vryonidou
Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogenous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during ageing, as well...
March 6, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28258132/mortality-in-graves-orbitopathy-is-increased-and-influenced-by-gender-age-and-pre-existing-morbidity-a-nationwide-danish-register-study
#13
Charlotte F Schwensen, Frans Brandt, Laszlo Hegedüs, Thomas Heiberg Brix
INTRODUCTION: It is unclear whether the excess mortality associated with Graves' disease differs between individuals with Graves' orbitopathy (GO) and without (GD). SUBJECTS AND METHODS: A nation-wide, register-based cohort study in which all adult Danes diagnosed with GD (n=28,461) and GO (n=3,965) between 1995-2012 were matched for age and gender with four control subjects. Median follow-up time was 7.9 years (range 0-17.5). Mortality risk in GO patients compared to the control population, and compared to GD patients were calculated using Cox regression analyses, adjusting for pre-existing morbidity using the Charlson score...
March 3, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28258131/diagnosis-of-endocrine-disease-expanding-the-cause-of-hypopituitarism
#14
Sandra Pekic, Vera Popovic
Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of hypopituitarism associated with a sellar mass is a pituitary adenoma. A high index of suspicion is required for diagnosing hypopituitarism in several other conditions such as: other massess in the sellar and parasellar region, brain damage caused by radiation and by traumatic brain injury, vascular lesions, infiltrative/immunological/inflammatory diseases (lymphocytic hypophysitis, sarcoidosis, hemochromatosis), infectious diseases and genetic disorders...
March 3, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28249955/clinical-and-biochemical-characteristics-and-bone-mineral-density-of-homozygous-compound-heterozygous-and-heterozygous-carriers-of-three-novel-igfals-mutations
#15
Emregül Işık, Belma Haliloglu, Jaap Van Doorn, Huseyin Demirbilek, Sitha A Scheltinga, Monique Losekoot, Jan M Wit
OBJECTIVE: Acid Labile Subunit (ALS) deficiency (ACLSD), caused by homozygous or compound heterozygous IGFALS mutations, is associated with moderate short stature, delayed puberty, low serum IGF-I and ALS and extremely low serum IGFBP-3. The effect on birth weight, head circumference, bone mineral density (BMD), serum IGF-II and IGFBP-2 is uncertain, as well as the phenotype of heterozygous carriers of IGFALS mutations (partial ACLSD). DESIGN: From all available members of five Turkish families, carrying three novel mutations in exon 2 of IGFALS (c...
March 1, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28246151/mechanisms-in-endocrinology-endocannabinoids-and-metabolism-past-present-and-future
#16
Vincent Simon, Daniela Cota
The endocannabinoid system (ECS), including cannabinoid type 1 and type 2 receptors (CB1R and CB2R), endogenous ligands called endocannabinoids and their related enzymatic machinery, is known to have a role in the regulation of energy balance. Past information generated on the ECS, mainly focused on the involvement of this system in the central nervous system regulation of food intake, while at the same time clinical studies pointed out the therapeutic efficacy of brain-penetrant CB1R antagonists like rimonabant for obesity and metabolic disorders...
February 28, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28246150/changes-in-the-management-and-comorbidities-of-acromegaly-over-three-decades-the-french-acromegaly-registry
#17
Luigi Maione, Thierry Brue, Albert Beckers, Brigitte Delemer, Patrick Petrossians, Francoise Borson-Chazot, Olivier Chabre, Patrick Francois, Jerome Bertherat, Christine Cortet, Philippe Chanson
CONTEXT: Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN: The French registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and prospectively from 1999 until 2012. RESULTS: Data could be analyzed for 999 of the 1034 patients included in the registry (46% males)...
February 28, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28246149/associations-between-serum-levels-of-calcium-parathyroid-hormone-and-future-risk-of-venous-thromboembolism-the-troms%C3%A3-study
#18
Gunhild Lerstad, Ellen Brodin, Johan Svartberg, Rolf Jorde, Jan Brox, Sigrid Brækkan, John-Bjarne Hansen
OBJECTIVE: The relationship between serum levels of calcium, parathyroid hormone (PTH) and risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the associations between serum levels of calcium and PTH, with future risk of VTE in a general adult population. DESIGN: Population-based cohort Methods: A total of 27,712 subjects (25-87 years) who participated in Tromsø 4 (1994-95) and Tromsø 5 (2001-02) surveys were included in the study, and total calcium and PTH were measured in 27,685 and 8,547 subjects, respectively...
February 28, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28232370/eje-prize-2017-hypothalamic-ampk-a-golden-target-against-obesity
#19
Miguel Lopez
AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions of low energy, increasing energy production and reducing energy waste. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, with neuronal networks. Current evidence links hypothalamic AMPK with feeding, brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT), as well as muscle metabolism, hepatic function and glucose homeostasis...
February 23, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28232369/mechanisms-in-endocrinology-epigenetic-modifications-and-gestational-diabetes-a-systematic-review-of-published-literature
#20
Gunn-Helen Moen, Christine Sommer, Rashmi Prasad, Line Sletner, Leif Groop, Elisabeth Qvigstad, Kåre I Birkeland
OBJECTIVE: To summarize the current knowledge on epigenetic alterations in mother and offspring subjected to gestational diabetes (GDM), and indicate future topics for research. DESIGN: Systematic review. METHODS: We performed extensive searches in PubMed, EMBASE and Google scholar, using a combination of the search terms: GDM, gestational diabetes, epigenetic(s), methylation, histone modification, histone methylation, histone acetylation, microRNA and miRNA...
February 23, 2017: European Journal of Endocrinology
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