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European Journal of Endocrinology

Svenja Boekhoff, Agnieszka Bogusz, Anthe Suzan Sterkenburg, Maria Eveslage, Hermann L Müller
OBJECTIVE: Quality of survival, prognosis and long-term outcome are often severely impaired in childhood-onset craniopharyngioma patients (CP). Identification of risk factors for sequelae such as growth hormone (GH) deficiency is important for appropriate treatment and rehabilitation. DESIGN: In a cross-sectional study, 79 CP recruited in HIT-Endo before 2000 were analyzed according to GH substitution: a. CP never GH-treated (noGH); b. CP GH-treated only during childhood (pedGH); c...
August 23, 2018: European Journal of Endocrinology
Monica Marazuela, Ana María Ramos-Leví, Patricia Borges de Souza, Maria Chiara Zatelli
Medical treatment of pituitary tumours may present important challenges in the presence of resistance to first line therapy. In this setting, the availability of specific markers of responsiveness/resistance could be helpful to provide tailored patients' treatment. Pituitary receptor profiling has emerged as a potentially useful tool for predicting the response to specific pituitary-directed medical therapy, mainly somatostatin analogues and dopamine agonists. However, its utility is not always straightforward...
August 23, 2018: European Journal of Endocrinology
Peter Ebeling, Robert Adler, Glenville Jones, Uri A Liberman, Gherando Mazziotti, Salvatore Minisola, Craig Munns, Nicola Napoli, Anastassios Pittas, Andrea Giustina, John P Bilezikian, Rene Rizzoli
Objective The central role of vitamin D in bone health is well recognized. However, controversies regarding its clinical application remain. We therefore aimed to review the definition of hypovitaminosis D, the skeletal and extra-skeletal effects of vitamin D, and the available therapeutic modalities. Design Narrative and systematic literature review. Methods An international working group that reviewed the current evidence linking bone and extra-skeletal health and vitamin D therapy to identify knowledge gaps for future research...
August 21, 2018: European Journal of Endocrinology
Michelle Henry, Ian Louis Ross, Kevin Garth Flusk Thomas
OBJECTIVES: Cortisol plays a key role in initiating and maintaining different sleep stages. Patients with Addison's disease (AD) frequently report disrupted sleep, and their hydrocortisone medication regimes do not restore the natural diurnal rhythm of cortisol. However, few studies have investigated relations between sleep quality, especially as measured by polysomnographic equipment, and night-time cortisol concentrations in patients with AD. METHODS: We used sleep-adapted EEG to monitor a full night of sleep in 7 patients with AD and 7 healthy controls...
August 14, 2018: European Journal of Endocrinology
Flavia Maurice, Anne Dutour, Clara Vincentelli, Ines Abdesselam, Monique Bernard, Henry Dufour, Yann Le Fur, Thomas Graillon, Frank Kober, Pierre Cristofari, Elisabeth Jouve, Lauriane Pini, Remi Fernandez, Christophe Chagnaud, Thierry Brue, Frédéric Castinetti, Benedicte Gaborit
OBJECTIVE: Glucocorticoid excess is one of the most important causes of bone disorders. Bone marrow fat (BMF) has been identified as a l new mediator of bone metabolism. Cushing syndrome (CS), is a main regulator of adipose tissue distribution but its impact on BMF is unknown. The objective of the study was to evaluate the effect of chronic hypercortisolism on BMF. DESIGN: This was a cross-sectional study. Seventeen active and seventeen cured ACTH-dependent CS patients along with seventeen controls (matched with the active group for age and sex) were included...
August 14, 2018: European Journal of Endocrinology
Usman Arshad, Max Taubert, Max Kurlbaum, Sebastian Frechen, Sabine Herterich, Felix Megerle, Stefanie Hamacher, Martin Fassnacht, Uwe Fuhr, Matthias Kroiss
OBJECTIVE: Mitotane is used for the treatment of adrenocortical carcinoma. High oral daily doses of typically 1- 6 g are required to attain therapeutic concentrations. The drug has a narrow therapeutic index and patient management is difficult because of a high volume of distribution, very long elimination half-life, and drug interaction through induction of metabolizing enzymes. The present evaluation aimed at the development of a population pharmacokinetic model of mitotane to facilitate therapeutic drug monitoring...
August 7, 2018: European Journal of Endocrinology
Alina German, Mishael Shmoish, Jay Belsky, Zeev Hochberg
BACKGROUND: The relationship between pubertal onset and tempo and pubertal growth is controversial. We hypothesized that the age at onset of girls' puberty predicts pubertal tempo and the rate of pubertal progression. METHODS: We analysed the data of 380 girls from the prospective Study of Early Child Care and Youth Development (SECCYD), who were recruited in the USA from 1991-2006 and followed from birth to age 15.5 years. We used the following indicators: thelarche age (Tanner stage B2), pubarche age (P2), menarche age (M), the age when breast (B5) and pubic hair (P5) became fully mature, pubertal growth, pubertal duration (time from B2 to B5), pubertal progression (time from B2 to M)...
August 7, 2018: European Journal of Endocrinology
Ammar Muhammad, Eva C Coopmans, Patrick Delhanty, Alof H G Dallenga, Iain K Haitsma, Joseph A M J L Janssen, A J Van der Lely, Sebastian J C M M Neggers
OBJECTIVE: to assess the efficacy and safety after 48 weeks of treatment with pasireotide long-acting-release (PAS-LAR) alone or in combination with pegvisomant in patients with acromegaly. In addition, we assessed the relation between insulin secretion and pasireotide-induced hyperglycemia. DESIGN: The PAPE extension study is a prospective follow-up study until 48 weeks after the core study of 24 weeks. METHODS: 59 out of 61 patients entered the extension study...
August 3, 2018: European Journal of Endocrinology
Carmina Teresa Fuss, Marcus Treitl, Nada Rayes, Petr Podrabsky, Wiebke Kristin Fenske, Daniel Alexander Heinrich, Martin Reincke, Tim-Ole Petersen, Martin Fassnacht, Marcus Quinkler, Ralph Kickuth, Stefanie Hahner
OBJECTIVE: Adrenal vein sampling (AVS) represents the current diagnostic standard for subtype differentiation in primary aldosteronism (PA). However, AVS has its drawbacks. It is invasive, expensive, requires an experienced interventional radiologist, and comes with radiation exposure. However, exact radiation exposure of patients undergoing AVS has never been examined. DESIGN AND METHODS: We retrospectively analyzed radiation exposure of 656 AVS performed between 1999 and 2017 at four university hospitals...
August 1, 2018: European Journal of Endocrinology
Espen Nordheim, Kåre I Birkeland, Anders Åsberg, Anders Hartmann, Rune Horneland, Trond Jenssen
Objective Successful simultaneous pancreas and kidney transplantation (SPK) or pancreas transplantation alone (PTA) restores glycemic control. Diabetes and impaired kidney function are common side-effects of immunosuppressive therapy. This study addresses glucometabolic parameters and kidney function during the first year. Methods We examined 67 patients with functioning grafts (SPK n=30, PTA n=37) transplanted between September 2011 and November 2016 who underwent repeated oral glucose tolerance tests (OGTTs) 8 and 52 weeks after transplantation...
July 30, 2018: European Journal of Endocrinology
Liset E M Elstgeest, Elisa J de Koning, Ingeborg A Brouwer, Natasja M van Schoor, Brenda W J H Penninx, Marjolein Visser
OBJECTIVE: Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. DESIGN: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. METHODS: Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65-88y, n=173), and in 2002/2003 and 6 years later in the younger cohort (55-65y, n=450)...
July 27, 2018: European Journal of Endocrinology
Casper Hammarstrand, Oskar Ragnarsson, Olivia Bengtsson, Ing-Liss Bryngelsson, Gudmundur Johannsson, Daniel S Olsson
BACKGROUND: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumours in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT). METHOD: Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987-2014...
July 26, 2018: European Journal of Endocrinology
Laetitia Martinerie, Agnes Condat, Anne Bargiacchi, Catherine Bremont-Weill, Martine C de Vries, Sabine E Hannema
Over the past 20 years, the care for transgender adolescents has developed throughout many countries following the "Dutch Approach" initiated in the 90's in pioneer countries as the Netherlands, United States and Canada, with increasing numbers of children and adolescents seeking care in transgender clinics. This medical approach has considerable positive impacts on the psychological outcomes of these adolescents and several studies have been recently published underlining the relative safety of such treatments...
July 26, 2018: European Journal of Endocrinology
Martin Fassnacht, Olaf Dekkers, Tobias Else, Eric Baudin, Alfredo Berruti, Ronald R de Krijger, H R Haak, Radu Mihai, Guillaume Assie, Massimo Terzolo
Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone producing tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. We predefined four main clinical questions, which we judged as particularly important for the management of ACC patients and performed systematic literature searches: (A) What is needed to diagnose an ACC by histopathology? (B) Which are the best prognostic markers in ACC? (C) Is adjuvant therapy able to prevent recurrent disease or reduce mortality after radical resection? (D) What is the best treatment option for macroscopically incompletely resected, recurrent or metastatic disease? Other relevant questions were discussed within the group...
July 24, 2018: European Journal of Endocrinology
Vince Kornél Grolmusz, Annamária Kövesdi, Katalin Borka, Peter Igaz, Attila Patocs
Objective Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas, however their prognosis differs significantly upon their proliferative state which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expression. Our aim was to identify miRNAs with altered expression upon proliferation which can be used as prognostic biomarkers in PanNENs. Methods MiRNA expression profiles of 40 PanNENs were downloaded from Gene Expression Omnibus and were reanalyzed upon tumor grades (discovery cohort)...
July 13, 2018: European Journal of Endocrinology
Nicolas Nicolaides, George Chrousos
Glucocorticoids signal through their cognate, ubiquitously expressed glucocorticoid receptor (GR), which influences the transcription of a large number of target genes. Several genetic defects, including point mutations, deletions or insertions in the NR3C1 gene that encodes the GR, have been associated with familial or sporadic generalized glucocorticoid resistance or Chrousos syndrome. One of the clinical manifestations of this rare endocrine condition is bilateral adrenal hyperplasia due to compensatory elevations of plasma ACTH concentrations...
July 13, 2018: European Journal of Endocrinology
Anjana Radhakutty, Morton G Burt
Glucocorticoids are frequently prescribed to patients with a wide range of inflammatory and autoimmune diseases. The semi-synthetic glucocorticoid prednisolone is most commonly prescribed and in two main patterns. Prednisolone is prescribed short-term at medium-high doses to treat an acute inflammatory illness or long-term at lower doses to attenuate chronic inflammatory disease progression. In hospitalized patients with acute prednisolone-induced hyperglycaemia there is a distinct circadian pattern of glucose elevation, which occurs predominantly in the afternoon and evening...
July 10, 2018: European Journal of Endocrinology
Laura Audí, S Faisal Ahmed, Nils Krone, Martine Cools, Ken McElreavey, Paul-Martin Holterhus, Andy Greenfield, Anu Bashamboo, Olaf Hiort, Stefan A Wudy, Ruth McGowan
The differential diagnosis of differences or disorders of sex development (DSD) belongs to the most complex fields in medicine. It requires a multidisciplinary team conducting a synoptic and complementary approach consisting of thorough clinical, hormonal and genetic workups. This position paper of EU COST (European Cooperation in Science and Technology) Action BM1303 "DSDnet" was written by leading experts in the field and focuses on current best practice in genetic diagnosis in DSD patients. Ascertainment of the karyotpye defines one of the three major diagnostic DSD subclasses and is therefore the mandatory initial step...
July 4, 2018: European Journal of Endocrinology
Athanasios Fountas, Shu Teng Chai, Chrysoula Kourkouti, Niki Karavitaki
The use of opioids has grown substantially over the past two decades reaching the dimensions of a global epidemic. These drugs have effects on multiple levels of the endocrine system through mechanisms which are still not fully elucidated, and awareness of their endocrine sequelae is vital for all specialists prescribing or managing patients on them. Hypogonadism is the most well recognised consequence of opioid use (prevalence 21-86%) which, however, may remain undiagnosed with potential adverse outcomes for the patients...
July 4, 2018: European Journal of Endocrinology
Tareck Rharass, Stephanie Lucas
Bone marrow adipocytes (BMA) constitute an original and heterogeneous fat depot whose development appears interlinked with bone status throughout life. The gradual replacement of the hematopoietic tissue by BMA arises in a well-ordered way during childhood and adolescence concomitantly to bone growth and continues at a slower rate throughout the adult life. Importantly, BM adiposity quantity is found well associated with BMD (Bone Mineral Density) loss at different skeletal sites in primary osteoporosis such as in ageing or menopause but also in secondary osteoporosis consecutive to anorexia nervosa...
July 4, 2018: European Journal of Endocrinology
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