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European Journal of Endocrinology

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https://www.readbyqxmd.com/read/28193628/management-of-endocrine-disease-neuroendocrine-surveillance-and-management-of-neurosurgical-patients-non-pituitary
#1
Aoife Garrahy, Mark Sherlock, Chris J Thompson
Advances in the management of traumatic brain injury, subarachnoid haemorrhage and intracranial tumours have led to improved survival rates and an increased focus on quality of life of survivors. Endocrine sequelae of the acute brain insult and subsequent neurosurgery, peri-operative fluid administration and/or cranial irradiation are now well described. Unrecognized acute hypopituitarism, particularly ACTH/cortisol deficiency and diabetes insipidus, can be life-threatening. While hypopituitarism may be transient, up to 30% of survivors of TBI have chronic hypopituitarism, which can diminish quality of life and hamper rehabilitation...
February 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28188242/diagnosis-of-endocrine-disease-steroid-hormone-analysis-in-diagnosis-and-treatment-of-dsd-position-paper-of-eu-cost-action-bm-1303-dsdnet
#2
Alexandra Kulle, Nils Krone, Paul-Martin Holterhus, Gerhard Schuler, Ronda Greaves, Anders Juul, Yolanda de Rijke, Michaela Hartmann, Alessandro Saba, Olaf Hiort, Stefan Wudy
Disorders or differences in sex development (DSD) comprise a heterogeneous group of conditions with an atypical sex development. For optimal diagnosis highly specialized laboratory analyses are required across European countries. Working group 3 of EU COST (European Cooperation in Science and Technology) Action BM 1303 "DSDnet" "Harmonisation of Laboratory Assessment" has developed recommendations on laboratory assessment for DSD regarding the use of technologies and analytes to be investigated. This position paper on steroid hormone analysis in diagnosis and treatment of DSD was compiled by a group of specialists in DSD and/or hormonal analysis, either from participating European Countries or international partner countries...
February 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179453/gynaecomastia-in-786-adult-men-clinical-and-biochemical-findings
#3
Mikkel G Mieritz, Peter Christiansen, Martin Blomberg Jensen, Ulla N Joensen, Loa Nordkap, Inge A Olesen, A Kirstine Bang, Anders Juul, Niels Joergensen
Objective - Gynaecomastia is a benign proliferation of glandular tissue of the breast, however, it is an important clinical observation because it can be the first symptom of an underlying disease. Some controversy exists concerning the clinical importance of an in-depth investigation of men who develop gynaecomastia. We hypothesize that a thorough work-up is required in adult men with gynaecomastia. Design- All adult men (n=818) referred to a secondary level andrological department at Rigshospitalet in Copenhagen, Denmark in a four-year period (2008-2011) under the diagnosis of gynaecomastia (ICD-10: N62) were included...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179452/risk-factors-for-post-thyroidectomy-hemorrhage-a-meta-analysis
#4
Jinhao Liu, Wei Sun, Wenwu Dong, Zhihong Wang, Ping Zhang, Ting Zhang, Hao Zhang
Background Post-thyroidectomy haemorrhage is a rare but potentially life-threatening and unpredictable complication of thyroid surgery. In this study, we analysed the potential risk factors for the occurrence of post-thyroidectomy haemorrhage. Methods The PubMed and SCIE databases were comprehensively searched for studies published before June 30, 2016. In this study, all patients underwent an open thyroidectomy, and RevMan 5.3 software was used to analyse the data. Results Twenty-five studies and 455242 patients were included in this meta-analysis, and post-thyroidectomy haemorrhage occurred in 6573 patients (incidence rate=1...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179451/cushing-s-syndrome-in-children-and-adolescents-a-danish-nationwide-population-based-cohort-study
#5
Johanne Marie Holst, Erzsébet Horváth-Puhó, Rb Jensen, Mariane Rix, Niels Thomas Hertel, Olaf Dekkers, Henrik Toft Sørensen, Anders Juul, Jens Otto L Jorgensen
OBJECTIVE: Cushing's syndrome (CS) affects all age groups, but epidemiologic data in young pa-tients are very limited. We therefore examined the incidence, prevalence, and hospital morbidity of CS in children and adolescents. DESIGN: In a nationwide cohort study we included all Danish citizens aged 0-20 years from 1977 to 2012. Data were obtained from the Danish National Patient Registry using the International Classi-fication of Diseases (ICD) codes and the Danish Civil Registration System...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179450/prevalence-incidence-and-associated-co-morbidities-of-treated-hypothyroidism-an-update-from-a-european-population
#6
Carlo B Giorda, Paolo Carnà, Francesco Romeo, Giuseppe Costa, Barbara Tartaglino, Roberto Gnavi
OBJECTIVE: Estimates of the prevalence of hypothyroidism in unselected populations date from the late 1990s. We present an update on the prevalence and incidence of overt hypothyroidism in Piedmont, northwest Italy, and examine the association between hypothyroidism and multiple chronic comorbidities. DESIGN AND METHODS: Data were obtained from drug prescription and hospital discharge databases. Individuals who had received at least two levothyroxine prescriptions in 2012 were defined as having hypothyroidism; those who had undergone thyroidectomy or I131 irradiation in the previous 5 years were defined as having iatrogenic hypothyroidism; and those who had either obtained exemption from treatment co-payment or had been discharged from hospital with a chronic comorbidity (diabetes, connective tissue diseases) were identified as having one of these conditions...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179449/the-gip-gipr-axis-is-functionally-linked-to-gh-secretion-increase-in-a-significant-proportion-of-gsp-somatotropinomas
#7
Daniela Regazzo, Marco Losa, Nora Albiger, Maria Rosa Terreni, Giovanni Vazza, Filippo Ceccato, Enzo Emanuelli, Luca Denaro, Carla Scaroni, Gianluca Occhi
Objective: Glucose-dependent insulinotropic polypeptide receptor (GIPR) overexpression has been recently described in a proportion of gsp(-) somatotropinomas and suggested to be associated with the paradoxical increase of GH (GH-PI) during an oral glucose load. Design and Methods: This study was aimed at linking the GIP/GIPR pathway to GH secretion in 25 somatotropinomas-derived primary cultures and correlating molecular with clinical features in acromegalic patients. Given the impairment of the GIPR/GIPR axis in acromegaly, an additional aim was to assess the effect of GH/IGF-1 stimulation on GIP expression in the enteroendocrine cell line STC-1...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179448/the-igf-system-in-patients-with-type-2-diabetes-associations-with-markers-of-cardiovascular-target-organ-damage
#8
Rikke Hjortebjerg, Esben Laugesen, Pernille Høyem, Claus Oxvig, Brian Stausbøl-Grøn, Søren Tang Knudsen, Won Y Kim, Per Løgstrup Poulsen, Tk K Hansen, Mette Bjerre, Jan Frystyk
OBJECTIVE: Perturbations in the insulin-like growth factor (IGF) system may contribute to the accelerated cardiovascular disease (CVD) that occurs in patients with type 2 diabetes (T2D). However, it remains unknown whether the IGF system is also involved in the development of early, subclinical CVD. We characterised the IGF system in T2D patients and matched controls and examined associations with markers of subclinical target organ damage. METHODS: The study included 99 patients with recently diagnosed T2D and 99 age- and sex-matched controls...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28179447/diagnosis-of-endocrine-disease-differentiation-of-pathologic-neoplastic-hypercortisolism-cushing-syndrome-from-physiologic-non-neoplastic-hypercortisolism-formerly-known-as-pseudo-cushing-syndrome
#9
James Findling, Hershel Raff
Endogenous hypercortisolism (Cushing syndrome) usually implies the presence of a pathologic condition caused by either an ACTH-secreting neoplasm or autonomous cortisol secretion from a benign or malignant adrenal neoplasm. However, sustained or intermittent hypercortisolism may also accompany many medical disorders that stimulate physiologic/non-neoplastic activation of the HPA axis (formerly known as pseudo-Cushing syndrome); these two entities may share indistinguishable clinical and biochemical features...
February 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28153840/diagnosis-of-endocrine-disease-endocrine-late-effects-of-childhood-cancer-and-its-treatments
#10
Wassim Chemaitilly, Laurie Cohen
Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his / her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-effects include impairments of the hypothalamus / pituitary, thyroid, and gonads, as well as decreased bone mineral density and metabolic derangements leading to obesity and/or diabetes mellitus...
February 2, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28137737/evidence-for-the-founder-effect-of-ret533-as-the-common-greek-and-brazilian-ancestor-spreading-multiple-endocrine-neoplasia-2a
#11
Lucas Leite Cunha, Susan Chow Lindsey, Maria Inez França, Leda Sarika, Alexandra Papathoma, Ilda S Kunii, Janete Maria Cerutti, Magnus R Dias-da-Silva, Maria Alevizaki, Rui M B Maciel
OBJECTIVES: About one quarter of patients with medullary thyroid cancer (MTC) have inherited disease due to mutations in the RET gene. A rare mutation in exon 8 (G533C) of RET, previously described in a large Brazilian family with MEN2A, appeared to be clustering also in Greece while it was rarely reported in other ethnic groups. The aim of this study was to identify a possible common ancestry between these carriers. PATIENTS AND METHODS: Twelve RET G533C mutation carriers, four randomly selected from the Brazilian cohort and eight from apparently unrelated Greek families, were studied for a possible common ancestral origin...
January 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28137736/high-sensitive-basal-serum-thyroglobulin-6-12-months-after-thyroid-ablation-is-strongly-associated-with-early-response-to-therapy-and-event-free-survival-in-patients-with-low-to-intermediate-risk-differentiated-thyroid-carcinomas
#12
Pierpaolo Trimboli, Valentina Zilioli, Mauro Imperiali, Luca Ceriani, Luca Giovanella
OBJECTIVE: High sensitive thyroglobulin assays (hsTg) has decreased the need for stimulated Tg measurements in patients with differentiated thyroid carcinoma (DTC). However, multiple assays analyzing the same samples may report different values. Accordingly, appropriate assay-specific cut-off levels should be selected in representative patients series. Here we evaluate the role of a new hsTg assay in low to intermediate risk DTC patients and select appropriate assay-specific clinical cut-off limits...
January 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28137735/contact-system-activation-and-high-thrombin-generation-in-hyperthyroidism
#13
Namhee Kim, Ja-Yoon Gu, Hyun Ju Yoo, Se Eun Han, Young Il Kim, Il Seong Nam-Goong, Eun Sook Kim, Hyun Kyung Kim
Background Hyperthyroidism is associated with increased thrombotic risk. Since contact system activation through formation of neutrophil extracellular traps (NET) has emerged as an important trigger of thrombosis, we hypothesized that the contact system is activated along with active NET formation in hyperthyroidism and that their markers correlate with disease severity. Materials and Methods In 61 patients with hyperthyroidism and 40 normal controls, the levels of coagulation factors (fibrinogen, and factor VII, VIII, IX, XI, and XII), D-dimer, thrombin generation assay (TGA) markers, NET formation markers (histone-DNA complex, double-stranded DNA, neutrophil elastase), and contact system markers (activated factor XII [XIIa], high-molecular-weight kininogen [HMWK], prekallikrein, and bradykinin) were measured...
January 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28137734/early-thyroxine-treatment-in-down-syndrome-and-thyroid-function-later-in-life
#14
Nitash Zwaveling-Soonawala, Emma Witteveen, Jan Pieter Marchal, Femke Klouwer, Nadine Ikelaar, Anne Smets, Rick van Rijn, E Endert, Eric Fliers, Paul van Trotsenburg
OBJECTIVE: The hypothalamus-pituitary-thyroid (HPT) axis set point develops during the fetal period and first two years of life. We hypothesized that thyroxine treatment during these first two years, in the context of a randomized controlled trial (RCT) in children with Down syndrome, may have influenced the HPT-axis set point and may also have influenced the development of Down syndrome associated autoimmune thyroiditis. METHODS: We included 123 children with Down syndrome 8...
January 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28122810/testosterone-prevents-protein-loss-via-the-hepatic-urea-cycle-in-human
#15
Teresa Lam, Anne Poljak, Mark McLean, Neha Bahl, Ken K Y Ho, Vita Birzniece
CONTEXT: The urea cycle is a rate limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE: To determine whether testosterone reduces hepatic urea production. DESIGN: an open label study Patients and Intervention: Eight hypogonadal men were studied at baseline, and after two weeks of transdermal testosterone replacement (Testogel, 100 mg/day)...
January 25, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28115464/management-of-endocrine-disease-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency-update-in-management-of-adult-patients-and-prenatal-treatment
#16
Anne Bachelot, Virginie Grouthier, Carine Courtillot, Jerome Dulon, Philippe Touraine
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is characterized by cortisol and in some cases aldosterone deficiency associated with androgen excess. Goals of treatment are to replace deficient hormones and control androgen excess, while avoiding the adverse effects of exogenous glucocorticoid (GC). Over the last 5 years, cohorts of adults with CAH due to 21hydroxylase deficiency from Europe and the United States have been described, allowing us to have a better knowledge of long-term complications of the disease and its treatment...
January 23, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100632/the-role-of-hepatic-trans-arterial-chemoembolization-in-metastatic-medullary-thyroid-carcinoma-a-specialist-center-experience-and-review-of-the-literature
#17
Simona Grozinsky-Glasberg, Allan Bloom, Naama Lev-Cohain, Alexander Klimov, Hashem Besiso, David Gross
BACKGROUND: Liver metastases are relatively common in patients with metastatic medullary thyroid carcinoma (MTC), carrying a negative impact on disease prognosis. The options for selective therapy of liver metastases in MTC patients are limited to catheter guided procedures such as trans-arterial chemoembolization (TACE). Data regarding the effectiveness and safety of this procedure in MTC is limited. AIM: To explore the clinical outcome, survival and safety profile of TACE for liver metastases in a group of MTC patients...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100631/association-of-triiodothyronine-levels-with-future-development-of-metabolic-syndrome-in-euthyroid-middle-aged-subjects-a-6-year-retrospective-longitudinal-study
#18
Hye Jeong Kim, Ji Cheol Bae, Hyeong Kyu Park, Dong Won Byun, Kyo Il Seo, Myung Hi Yoo, Jae Hwan Jee, Jae Hyeon Kim, Yong-Ki Min, Sun Wook Kim, Jae Hoon Chung
Background Several cross-sectional studies have reported that thyroid hormone levels are associated with cardiovascular risk markers and metabolic syndrome (MetS) even in euthyroid subjects. However, the prognostic role of serum thyroid hormone levels in the risk of incident MetS has not been elucidated. Aim We aimed to investigate the associations of baseline serum thyroid hormone levels with the development of MetS in healthy subjects. Methods This 6-year, cross-sectional, longitudinal and follow-up study was conducted in 12,037 euthyroid middle-aged subjects without MetS subjected to comprehensive health examinations...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100629/impact-of-food-alcohol-and-ph-on-modified-release-hydrocortisone-developed-to-treat-congenital-adrenal-hyperplasia
#19
Nayananjani Karunasena, Daniel Margetson, Greg Neal, Martin Whitaker, Richard J Ross
BACKGROUND: We developed a modified-release hydrocortisone, Chronocort®, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug absorption and it is important to assess their impact when replicating a physiological rhythm. SUBJECTS AND METHODS: In vitro dissolution to study impact of alcohol and pH on Chronocort®. A Phase 1, three-period, cross over study in 18 volunteers to assess the impact of food on Chronocort® and to compare bioavailability to immediate-release hydrocortisone...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28100628/external-validation-of-the-great-score-to-predict-relapse-risk-in-graves-disease-results-from-a-multicenter-retrospective-study-with-741-patients
#20
Tristan Struja, Marina Kaeslin, Fabienne Boesiger, Rebecca Jutzi, Noemi Imahorn, Alexander Kutz, Luca Bernasconi, Esther Mundwiler, Beat Mueller, Mirjam Christ-Crain, Fabian Meienberg, Fahim Ebrahimi, Christoph Henzen, Stefan Fischli, Marius Kraenzlin, Christian Meier, Philipp Schuetz
CONTEXT: First line treatment in Graves' disease is often done with antithyroid agents (ATD) but relapse rates remain high making definite treatment necessary. Predictors for relapse risk help guiding initial treatment decisions. OBJECTIVE: We aimed to externally validate the prognostic accuracy of the recently proposed Graves' Recurrent Events After Therapy [GREAT] score to predict relapse risk in Graves` disease. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed data (2004-2014) of patients with a first episode of Graves' hyperthyroidism from four Swiss endocrine outpatient clinics...
January 18, 2017: European Journal of Endocrinology
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