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Virchows Archiv: An International Journal of Pathology

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https://www.readbyqxmd.com/read/28083673/erratum-to-abstracts-xxxi-international-congress-of-the-iap-and-28th-congress-of-the-esp
#1
S De Rosa, L Libera, F Magnoli, C Capella, F Sessa, A M Chiaravalli
No abstract text is available yet for this article.
January 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28078436/adhering-to-the-2014-who-terminology-on-borderline-ovarian-tumors
#2
Jaime Prat
No abstract text is available yet for this article.
January 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28074276/in-stage-pt1-non-muscle-invasive-bladder-cancer-nmibc-high-krt20-and-low-krt5-mrna-expression-identify-the-luminal-subtype-and-predict-recurrence-and-survival
#3
Johannes Breyer, Ralph M Wirtz, Wolfgang Otto, Philipp Erben, Maximilian C Kriegmair, Robert Stoehr, Markus Eckstein, Sebastian Eidt, Stefan Denzinger, Maximilian Burger, Arndt Hartmann
Differential expression of cytokeratins (CK) is a characteristic feature of chemoresistant luminal (KRT20) and chemosensitive intrinsic aggressive basal (KRT5) subtypes in muscle-invasive bladder cancer (MIBC). We investigated mRNA expression of KRT5 and KRT20 and its predictive value in stage pT1 bladder cancer. In retrospective analysis of clinical data and formalin-fixed paraffin-embedded tissues (FFPE) of patients with stage pT1 NMIBC who underwent transurethral resection of the bladder, a single-step RT-qPCR was used to measure mRNA expression...
January 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28070642/distinct-expression-profile-of-stem-cell-markers-lgr5-and-lgr6-in-basaloid-skin-tumors
#4
Bo Gun Jang, Cheol Lee, Hye Sung Kim, Myung Soo Shin, Min Seok Cheon, Jae Wang Kim, Woo Ho Kim
Mammalian epidermis, which is composed of hair follicles, sebaceous glands, and interfollicular epidermis, is maintained by discrete stem cells. In vivo lineage tracing demonstrated that murine LGR5 cells are mainly responsible for hair follicle regeneration whereas LGR6 cells generate sebaceous glands and interfollicular epidermis. However, little is known about their expression in the human skin tumors. In this study, we investigated the expression profile of LGR5 and LGR6 in a variety of human skin tumors including basaloid tumors with follicular differentiation (94 basal cell carcinomas, 18 trichoepitheliomas, 3 basaloid follicular hamartomas, and 12 pilomatricomas) and tumors with ductal differentiation (7 eccrine poromas, 8 hidradenomas, and 5 spiradenomas)...
January 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28062918/glycine-decarboxylase-and-hif-1%C3%AE-expression-are-negative-prognostic-factors-in-primary-resected-early-stage-non-small-cell-lung-cancer
#5
Sabina Berezowska, José A Galván, Rupert Langer, Lukas Bubendorf, Spasenija Savic, Mathias Gugger, Ralph A Schmid, Thomas M Marti
Glycine decarboxylase (GLDC) was recently described as a critical enzyme of tumor-initiating cells and, thus, a driver of tumorigenesis in lung non-small cell cancer (NSCC). It is important in metabolism under hypoxic conditions. Hypoxia-inducible factor 1-alpha (HIF-1α) is the unique subunit that determines HIF system activity, thereby regulating the adverse effects of hypoxia on cancer outcome. We examined the expression and prognostic significance of GLDC and HIF-1α in primary resected stage I/II NSCC...
January 7, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28062917/the-enteric-nervous-system-and-the-musculature-of-the-colon-are-altered-in-patients-with-spina-bifida-and-spinal-cord-injury
#6
Marjanne den Braber-Ymker, Martin Lammens, Michel J A M van Putten, Iris D Nagtegaal
Neurogenic bowel dysfunction occurs in a large percentage of adult patients with spina bifida (SB) and spinal cord injury (SCI), significantly affecting their quality of life. Although bowel motility is autonomously regulated by the enteric nervous system (ENS), disruption of the modulation of the ENS by extrinsic innervation as present in many patients with SB and SCI might lead to motility disorders. In order to gain insight in the pathophysiology, we studied histological changes of the neuromuscular structures in the colon of SB and SCI patients...
January 6, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28054151/immunoplasticity-in-cutaneous-melanoma-beyond-pure-morphology
#7
REVIEW
Francesca Maria Bosisio, Joost J van den Oord
No abstract text is available yet for this article.
January 5, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28054150/ki-67-labeling-index-of-neuroendocrine-tumors-of-the-lung-has-a-high-level-of-correspondence-between-biopsy-samples-and-surgical-specimens-when-strict-counting-guidelines-are-applied
#8
Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Mauro Papotti, Luisella Righi, Gaia Gatti, Patrick Maisonneuve, Barbara Valeri, Ugo Pastorino, Giuseppe Pelosi
Optimal histopathological analysis of biopsies from metastases of neuroendocrine tumor (NET) of the lung requires more than morphology only. Additional parameters such as Ki-67 labeling index are required for adequate diagnosis, but few studies have compared reproducibility of different counting protocols and modalities of reporting on biopsies of lung NET. We compared the results of four different manual counting techniques to establish Ki-67 LI. On 47 paired biopsies and surgical specimens from 22 typical carcinoids (TCs), 14 atypical carcinoids (ACs), six large cell neuroendocrine carcinomas (LCNECs), and five small cell carcinomas (SCCs) immunohistochemical staining of Ki-67 antigen was performed...
January 4, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28025670/ovarian-borderline-tumors-in-the-2014-who-classification-evolving-concepts-and-diagnostic-criteria
#9
REVIEW
Steffen Hauptmann, Katrin Friedrich, Raymond Redline, Stefanie Avril
Borderline ovarian tumors (BOT) are uncommon but not rare epithelial ovarian neoplasms, intermediate between benign and malignant categories. Since BOT were first identified >40 years ago, they have inspired controversies disproportionate to their incidence. This review discusses diagnostic criteria for the histologic subtypes of BOT, highlighting areas of diagnostic challenges, ongoing controversies, and changes in terminology implemented by the recent 2014 WHO Classification of Tumours of the Female Genital Organs...
December 27, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28012069/virchows-archiv-an-update-and-plans-for-the-future
#10
EDITORIAL
Daniela Massi
No abstract text is available yet for this article.
December 24, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28004187/erratum-to-abstracts-xxxi-international-congress-of-the-iap-and-28th-congress-of-the-esp
#11
Bianca Machado, Catarina Meireles, Ana Pires-Luís, Manuel Jácome
No abstract text is available yet for this article.
December 22, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27981346/altered-expression-of-apoptosis-regulating-mirnas-in-salivary-gland-tumors-suggests-their-involvement-in-salivary-gland-tumorigenesis
#12
Bianca de Cássia Troncarelli de Campos Parra Flores, Silvia Vanessa Lourenço, Aline Santos Damascena, Luiz Paulo Kowaslki, Fernando Augusto Soares, Cláudia Malheiros Coutinho-Camillo
Salivary gland tumors comprise a heterogeneous group of lesions with different histological features and diverse clinical pathophysiology. They account for about 3% of all head and neck tumors. Apoptosis plays an important role during morphogenesis of glandular structures, including that of the salivary gland. Recent studies have demonstrated that several microRNAs (miRNAs) are involved in the control of apoptosis. The aim of the present study was to determine the expression of apoptosis-related miRNAs (miR-15a, miR-16, miR-17-5p, miR-20a, miR-21, miR-29, and miR-34) and their target mRNAs in 25 pleomorphic adenomas, 23 mucoepidermoid carcinomas, and 10 non-neoplastic salivary gland samples by real-time RT-PCR...
December 15, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27975126/value-of-postmortem-studies-in-deceased-neonatal-and-pediatric-intensive-care-unit-patients
#13
Raphael Widmann, Rosmarie Caduff, Luca Giudici, Qing Zhong, Alexander Vogetseder, Romaine Arlettaz, Bernhard Frey, Holger Moch, Peter K Bode
Worldwide, various autopsy studies have shown a decrease in the diagnostic error rate over the last years. The cause of this positive development is mainly due to the improvement of modern medicine. However, intensive care unit patients are thought to have a higher risk for diagnostic errors, which is documented in several studies in the adult population. In contrast, there is only limited information about diagnostic errors in pediatrics, particularly in pediatric and neonatal intensive care units. The aims of this study were to analyze the spectrum of childhood death, determine the prevalence and distribution of autopsy-confirmed diagnostic errors, and describe patient characteristics that might have influenced the discordance between antemortem and postmortem findings...
December 14, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27933386/endoscopic-submucosal-dissection-specimens-in-early-colorectal-cancer-lateral-margins-macroscopic-techniques-and-possible-pitfalls
#14
Alicia Dessain, Christophe Snauwaert, Pamela Baldin, Pierre Deprez, Louis Libbrecht, Hubert Piessevaux, Anne Jouret-Mourin
Endoscopic submucosal dissection (ESD) allows en-bloc resection of superficial gastrointestinal tumors, providing specimens on which lateral margin analysis can be performed reliably. Positive lateral margins have been linked to higher rates of recurrence/residual tumor. There are no guidelines for macroscopic processing of lateral margins. Currently, most institutions use parallel lateral sections, which are difficult to interpret. We use perpendicular lateral sections, hypothesizing that it decreases potential artifactually positive lateral margins...
December 8, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27915441/ovarian-metastasis-from-uveal-melanoma-with-mlh1-pms2-protein-loss-in-a-patient-with-germline-mlh1-mutated-lynch-syndrome-consequence-or-coincidence
#15
João Lobo, Carla Pinto, Micaela Freitas, Manuela Pinheiro, Rámon Vizcaino, Esther Oliva, Manuel R Teixeira, Carmen Jerónimo, Carla Bartosch
Currently, uveal melanoma is not considered within the Lynch syndrome tumor spectrum. However, there are studies suggesting a contribution of microsatellite instability in sporadic uveal melanoma tumorigenesis. We report a 45-year-old woman who was referred for genetic counseling due to a family history of Lynch syndrome caused by a MLH1 mutation. She originally underwent enucleation of the right eye secondary to a uveal spindle cell melanoma diagnosed at age 25. The tumor recurred 22 years later presenting as an ovarian metastasis and concurrently a microscopic endometrial endometrioid carcinoma, grade 1/3 was diagnosed...
December 3, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27915440/liver-steatosis-in-pre-transplant-liver-biopsies-can-be-quantified-rapidly-and-accurately-by-nuclear-magnetic-resonance-analysis
#16
Stefanie Bertram, Cathrin Myland, Sandra Swoboda, Anja Gallinat, Thomas Minor, Nils Lehmann, Michael Thie, Julia Kälsch, Leona Pott, Ali Canbay, Thomas Bajanowski, Henning Reis, Andreas Paul, Hideo A Baba
Donor livers marginally acceptable or acceptable according to extended criteria are more frequently transplanted due to the growing discrepancy between demand and availability of donor organs. One type of marginally acceptable graft is a steatotic donor liver, because it is more sensitive to ischemia-reperfusion injury. Thus, quantitative assessment of steatosis is crucial prior to liver transplantation. Extent of steatosis of 49 pre-reperfusion liver biopsies from patients who received orthotopic liver transplantation was assessed by three techniques: semi-quantitative histological evaluation, computerized histomorphometry, and NMR-based estimation of fat content...
December 3, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27913862/prognostic-impact-of-her3-based-on-protein-and-mrna-expression-in-high-grade-serous-ovarian-carcinoma
#17
Ulrike Unger, Carsten Denkert, Ioana Braicu, Jalid Sehouli, Manfred Dietel, Sibylle Loibl, Silvia Darb-Esfahani
HER3 is a member of the epidermal growth factor family and was predominantly described as a negative prognostic factor in various solid tumors as well as in ovarian cancer. In this study, we investigated HER3 on protein and mRNA expression in histologically defined subtypes of ovarian cancer looking for an influence on patient's survival. Altogether, we examined HER3 in ovarian high-grade serous (HGSC, n = 320), low-grade serous (LGSC, n = 55), endometrioid (EC, n = 33), and clear cell (CCC, n = 48) carcinomas using immunohistochemistry (IHC) and quantitative real-time reverse transcription PCR (qRT-PCR)...
December 2, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27913861/cxcl12-expression-and-pd-l1-expression-serve-as-prognostic-biomarkers-in-hcc-and-are-induced-by-hypoxia
#18
Alexander Semaan, Dimo Dietrich, Dominik Bergheim, Jörn Dietrich, Jörg C Kalff, Vittorio Branchi, Hanno Matthaei, Glen Kristiansen, Hans-Peter Fischer, Diane Goltz
Anti-PD-1 treatment increases anti-tumour immune responses in animal models of hepatocellular carcinoma (HCC). Sorafenib, the mainstay of treatment of HCC patients, however, leads to tumour hypoxia and thereby abrogates the efficacy of anti-PD-1 treatment. This served as a rationale to implement CXCR4 inhibition as adjunct to sorafenib and anti-PD-1 treatment in murine HCC models. We studied the relationship between tumour hypoxia, PD-L1 and CXCL12 expression in human HCC, aiming to test the rationale for triple therapy combining sorafenib, PD-1 immune checkpoint inhibitors and CXCR4 inhibitors...
December 2, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27909812/in-phyllodes-tumors-of-the-breast-expression-of-sparc-osteonectin-bm40-mrna-by-in-situ-hybridization-correlates-with-protein-expression-by-immunohistochemistry-and-is-associated-with-tumor-progression
#19
Nah Ihm Kim, Ga-Eon Kim, Ji Shin Lee, Min Ho Park
Secreted protein acidic and rich in cysteine (SPARC) plays an essential role in tumor invasion and metastasis. The present work was undertaken to detect expression of SPARC mRNA in phyllodes tumors (PTs) and its association with SPARC protein expression. This study also evaluated expression of SPARC mRNA and its correlation between grade and clinical behavior of PTs. In addition, we assessed in PTs the association of expression of SPARC with that of matrix metalloproteinase (MMP)-2 and of MMP-9. SPARC mRNA expression was determined by RNAscope in situ hybridization (ISH) in 50 benign, 22 borderline, and 10 malignant PTs using a tissue microarray...
December 1, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27888357/aberrant-cytoplasmic-expression-of-mhcii-confers-worse-progression-free-survival-in-diffuse-large-b-cell-lymphoma
#20
Samantha Kendrick, Lisa M Rimsza, David W Scott, Graham W Slack, Pedro Farinha, King L Tan, Daniel Persky, Soham Puvvada, Joseph M Connors, Laurie Sehn, Randy D Gascoyne, Monika Schmelz
No abstract text is available yet for this article.
November 25, 2016: Virchows Archiv: An International Journal of Pathology
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