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Virchows Archiv: An International Journal of Pathology

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https://www.readbyqxmd.com/read/30426205/implementation-of-modern-tools-in-autopsy-practice-the-way-towards-contemporary-postmortal-diagnostics
#1
Rupert Langer, Alexandra Tröhler, Beat Schnüriger, Mafalda Trippel, Annika Blank, Yara Banz, Daniel Candinas, Aurel Perren, Alessandro Lugli
Medical, legal, and socioeconomic issues have contributed to the decline of autopsy rates. Pathology-related factors, however, with changing clinical duties on the one hand and decreasing interest and lack of substantial technical developments in this field on the other, may have contributed to this condition as well. We present our experience of a restructuring project that culminated in the introduction of a modernized postmortal diagnostic (PMD) unit: Workflows of PMD procedures and space organization were restructured according to LEAN management principles method...
November 13, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30406424/braf-mutation-testing-in-melanoma-results-from-a-german-observational-multicenter-study
#2
Arndt Hartmann, Peter Schirmacher, William Sterlacci, Winfried Koch, David B Liesenfeld, Birgit Schif, Claus Garbe
Quality control of BRAF mutation testing methods used in routine practice is crucial for optimal treatment selection. In this prospective study, we assessed the impact of patient/sample characteristics on BRAF mutation testing results in patients with melanoma, during clinical practice. Data were collected on routine testing practices and documented mutation status in patients with melanoma stages IIIB, IIIC, or IV across 28 diagnostic pathology centers in Germany. Patient/sample data collected included: patient age, location of primary melanoma and metastases, origin of sample, melanoma subtype, and quality of tissue...
November 7, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30377796/prognostic-role-of-bap-1-and-pbrm-1-expression-in-intrahepatic-cholangiocarcinoma
#3
Samantha Sarcognato, Enrico Gringeri, Matteo Fassan, Michela Di Giunta, Valeria Maffeis, Vincenza Guzzardo, Umberto Cillo, Maria Guido
Intrahepatic cholangiocarcinoma (ICC) has universally poor outcome, mainly due to its late clinical presentation. Identification of specific biomarkers and development of effective treatment are still urgently required. Mutations in PBRM-1 and BAP-1 genes, and the expression of S100P have been related to survival in ICC. miR-31 seems also to play important regulatory functions in ICC and it directly regulates BAP-1 expression in lung cancer. In this study, tissue expression of BAP-1, PBRM-1, S100P, and miR-31 was investigated in ICC and correlated with clinical-pathological features...
October 30, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30374798/immunosuppressive-circuits-in-tumor-microenvironment-and-their-influence-on-cancer-treatment-efficacy
#4
REVIEW
Alessandra Tuccitto, Eriomina Shahaj, Elisabetta Vergani, Simona Ferro, Veronica Huber, Monica Rodolfo, Chiara Castelli, Licia Rivoltini, Viviana Vallacchi
It has been for long conceived that hallmarks of cancer were intrinsic genetic features driving tumor development, proliferation, and progression, and that targeting such cell-autonomous pathways could be sufficient to achieve therapeutic cancer control. Clinical ex vivo data demonstrated that treatment efficacy often relied on the contribution of host immune responses, hence introducing the concept of tumor microenvironment (TME), namely the existence, along with tumor cells, of non-tumor components that could significantly influence tumor growth and survival...
October 29, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30368555/high-expression-of-ccl2-in-tumor-cells-and-abundant-infiltration-with-cd14-positive-macrophages-predict-early-relapse-in-breast-cancer
#5
Marja Heiskala, Marjut Leidenius, Kristiina Joensuu, Päivi Heikkilä
Macrophages are important for the function of the innate immune system, and in solid tumors, they represent a significant proportion of the tumor mass. Tumor-associated macrophages (TAM) have a M2 phenotype and show a multitude of pro-tumoral functions, promoting tumor cell survival, proliferation, and dissemination. CCL2, synthesized by tumor and stromal cells, initiates a chemokine cascade inducing these processes. We studied by immunohistochemistry (IHC) the frequency of TAMs and CCL2 expressing cells in three groups of primary tumor (PT)-recurrence (R) pairs, where relapse was recorded within 2 years (group 1), between 5 and 10 years (group 2), and after 10 years (group 3)...
October 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30367239/can-the-classification-of-low-grade-endometrial-stromal-tumors-still-be-improved
#6
EDITORIAL
Xavier Matias-Guiu, Ben Davidson, Sigurd F Lax
No abstract text is available yet for this article.
October 26, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30357455/histopathology-of-livers-in-patients-with-congenital-portosystemic-shunts-abernethy-malformation-a-case-series-of-22-patients
#7
Claudio De Vito, Athanasios Tyraskis, Mark Davenport, Richard Thompson, Nigel Heaton, Alberto Quaglia
Congenital portosystemic shunt (CPSS) is a congenital anomaly resulting in partial or complete diversion of the portal blood into the systemic circulation. The literature on the histological changes in livers of patients with CPSS is limited. Liver histology of 22 consecutive patients managed in our institution between 2001 and 2016 was reviewed. Twenty-one patients were children at the time of diagnosis. Thirty-two specimens were available and consisted of three explant livers and 29 biopsy samples from 19 patients...
October 24, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30349952/evi1-expression-is-associated-with-aggressive-behavior-in-intrahepatic-cholangiocarcinoma
#8
Mariko Tanaka, Junji Shibahara, Shumpei Ishikawa, Tetsuo Ushiku, Teppei Morikawa, Aya Shinozaki-Ushiku, Akimasa Hayashi, Kento Misumi, Atsushi Tanaka, Hiroto Katoh, Kei Sakuma, Takashi Kokudo, Yoshinori Inagaki, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Masashi Fukayama
Ecotropic virus integration site 1 protein homolog (EVI1), a well-known oncogenic transcriptional factor of hematopoietic cells, contributes to pancreatic cancer oncogenicity through increased expression of KRAS. Because EVI1 was upregulated in cholangiocarcinoma by referring The Cancer Genome Atlas, we investigated the importance of EVI1 in intrahepatic cholangiocarcinoma (ICC) which has been regarded as a heterogeneous group of cancers. Immunohistochemical analysis results demonstrated that EVI1 was overexpressed in about half of ICC (53/101, 52...
October 23, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30338346/insulin-like-growth-factor-1-receptor-expression-in-upper-tract-urothelial-carcinoma
#9
Marie-Lisa Eich, Aline C Tregnago, Sheila F Faraj, Doreen N Palsgrove, Kazutoshi Fujita, Stephania M Bezerra, Enrico Munari, Rajni Sharma, Alcides Chaux, George J Netto
Insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase receptor that plays a crucial role in cell proliferation, growth, differentiation, and apoptosis. IGF1R overexpression has been observed in several cancers, including invasive bladder carcinomas, as a potential prognostic factor. Given known biologic differences between upper and lower urinary tract urothelial carcinoma, we assessed the expression status and prognostic significance of IGF1R in upper tract urothelial carcinoma (UTUC)...
October 18, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30328502/correction-to-abstracts-30th-european-congress-of-pathology
#10
N Nizyaeva, G Khlestova, A Yu Romanov, T Yu Ivanets, S Mullabaeva, S Pavlovich, O Baev
In Poster Sessions, the author name G. Khlestova was incorrectly presented as 'K. Galina' in the authorship group for Abstract PS-18-017 (page S151). The name has been corrected in the authorship group shown above.
October 17, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30327882/pleuroparenchymal-fibroelastosis-as-a-histological-background-of-autoimmune-diseases
#11
Yoshiaki Kinoshita, Kentaro Watanabe, Hiroshi Ishii, Hisako Kushima, Makoto Hamasaki, Masaki Fujita, Kazuki Nabeshima
Patients with autoimmune disease-related interstitial lung disease (AID-ILD) occasionally develop radiologic pleuroparenchymal fibroelastosis (PPFE)-like lesions. However, the significance of AID as an etiology of PPFE has not been fully elucidated. The aim of this study is to verify the increase of elastic fibers in AID-ILD patients and evaluate the prevalence of histological PPFE in patients with AID-ILD. We selected cases of clinically diagnosed AID-ILD and idiopathic pulmonary fibrosis (IPF), in which an autopsy had been performed or in which the patient had undergone pneumonectomy for lung transplantation...
October 16, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30324235/trefoil-factor-family-2-protein-a-potential-immunohistochemical-marker-for-aiding-diagnosis-of-lobular-endocervical-glandular-hyperplasia-and-gastric-type-adenocarcinoma-of-the-uterine-cervix
#12
Shiho Asaka, Tomoyuki Nakajima, Masanobu Momose, Tsutomu Miyamoto, Takeshi Uehara, Hiroyoshi Ota
Gastric-type adenocarcinoma (GA) is an aggressive subtype of cancer of the uterine cervix. Several immunohistochemical markers for gastric mucins, such as mucin 6 (MUC6) and N-acetylglucosamine α1 → 4galactose → R (αGlcNAc-R), which is recognized by HIK1083 antibody, have been introduced for diagnosis of GA and lobular endocervical glandular hyperplasia (LEGH). However, MUC6 is also expressed in normal endocervical glands and HIK1083 antibody has limited availability. Trefoil factor family 2 protein (TFF2) is secreted by gastric, but not normal endocervical glands...
October 15, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30324234/recent-advances-in-the-histological-and-molecular-classification-of-endometrial-stromal-neoplasms
#13
REVIEW
Joana Ferreira, Ana Félix, Jochen K Lennerz, Esther Oliva
This review addresses known features and recent developments in the histological, immunohistochemical, and molecular characterization of endometrial stromal neoplasms. We discuss the spectrum of these tumors, from the benign endometrial stromal nodule to low-grade endometrial stromal sarcoma to uterine undifferentiated sarcomas with a special emphasis on the expanding group of high-grade stromal sarcomas, recently added to the 2014 WHO classification, not only discussing the well-established YWHAE-FAM22 tumors but also two new groups, presenting with BCOR alterations including those with BCOR tandem internal duplications or NTRK fusions...
October 15, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30315357/book-review-diagnostic-pathology-cardiovascular-2nd-edition
#14
Cristina Basso
No abstract text is available yet for this article.
October 12, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30310990/cic-fusion-positive-sarcoma-of-the-spermatic-cord
#15
Felix Bremmer, Alexander Fichtner, Ralph Triefenbach, Reinhard Inniger, Peter Mayer, Laura Lukat, Philipp Ströbel, Hans Ulrich Schildhaus
In addition to germ cell tumors and tumors of the sex cord stroma, the WHO classification of testis and paratesticular tumors also contains malignant soft tissue tumors. Among them, liposarcomas of the spermatic cord are the most common entities. Other mesenchymal tumors with smooth muscle, skeletal muscle, fibroblastic/myofibroblastic, or nerve sheath differentiation are rare. Ewing sarcoma is composed of uniform small round cells and typically characterized by translocations of the EWSR1 gene. In rare cases, Ewing sarcoma-like tumors lack an EWSR1 gene fusion...
October 11, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30306267/correction-to-gastrointestinal-juvenile-like-inflammatory-hyperplastic-mucosal-polyps-in-neurofibromatosis-type-1-with-no-concurrent-genetic-or-clinical-evidence-of-other-syndromes
#16
Gloria Ravegnini, Giuseppe Quero, Giulia Sammarini, Maria Cristina Giustiniani, Federica Castri, Maria Grazia Pomponi, Sabrina Angelini, Sergio Alfieri, Maurizio Genuardi, Giuseppe Zamboni, Riccardo Ricci
The authors regret that the original version of this article, unfortunately, contained an error. The values "1/3 (33%)" reported in the second to last sentence of the Discussion are wrong; the correct values are "2/2 (100%)". These are presented correctly in this article.
October 10, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30302546/urachal-carcinoma-from-gross-specimen-to-morphologic-immunohistochemical-and-molecular-analysis
#17
Giulio Riva, Christine Mian, Claudio Luchini, Ilaria Girolami, Claudio Ghimenton, Luca Cima, Luca Novelli, Esther Hanspeter, Guido Mazzoleni, Christine Schwienbacher, Stefan Pycha, Carolina D'Elia, Emanuela Trenti, Armin Pycha, Guido Martignoni, Ondrej Hes, Albino Eccher, Gabriella Nesi, Matteo Brunelli
Urachal carcinoma (UrC) is an exceedingly rare neoplasm that develops from the urachus, an embryologic remnant of the urogenital sinus and allantois. The most commonly encountered histologic subtype is adenocarcinoma. The aim of this study is to characterize a series of UrC by morphology, immunohistochemistry, and molecular analysis. We retrospectively investigated seven cases of UrCs and assessed patient symptoms, imaging, histologic features, immunohistochemical profile, molecular characteristics, pathologic stages, and type of treatment...
October 9, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30284611/progression-of-ductal-carcinoma-in-situ-to-invasive-breast-cancer-comparative-genomic-sequencing
#18
S C Doebar, N M Krol, R van Marion, R W W Brouwer, W F J van Ijcken, J M Martens, W N M Dinjens, C H M van Deurzen
Several models have been described as potential mechanisms for the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC). The aim of our study was to increase our understanding of DCIS progression by using massive parallel sequencing of synchronous DCIS and IBC. We included patients with synchronous DCIS and IBC (n = 4). Initially, IBC and normal tissue were subjected to whole exome sequencing. Subsequently, targeted sequencing was performed to validate those tumor-specific variants identified by whole exome sequencing...
October 4, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30276464/gastrointestinal-juvenile-like-inflammatory-hyperplastic-mucosal-polyps-in-neurofibromatosis-type-1-with-no-concurrent-genetic-or-clinical-evidence-of-other-syndromes
#19
Gloria Ravegnini, Giuseppe Quero, Giulia Sammarini, Maria Cristina Giustiniani, Federica Castri, Maria Grazia Pomponi, Sabrina Angelini, Sergio Alfieri, Maurizio Genuardi, Giuseppe Zamboni, Riccardo Ricci
Gastrointestinal "juvenile-like (inflammatory/hyperplastic) mucosal polyps" (JLIHMPs) have been proposed as a neurofibromatosis type 1 (NF1)-specific gastrointestinal manifestation. Juvenile polyposis syndrome (JPS) has also been reported in a NF1 patient, harboring concurrent NF1 and SMAD4 germline mutations. Additionally, NF1-like cafe-au-lait spots have been described in biallelic mismatch repair deficiency, another condition featuring gastrointestinal polyps. The SMAD4 and BMPR1A genes that are involved in 50-60% of JPS cases have not been investigated in the ~ 20 published cases of NF1-associated JLIHMPs with the exception of the abovementioned patient with concomitant JPS and NF1...
October 1, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30267303/rab14-overexpression-regulates-gemcitabine-sensitivity-through-regulation-of-bcl-2-and-mitochondrial-function-in-pancreatic-cancer
#20
Jinnian Ge, Chunlin Ge
Rab family protein Rab14 has been implicated in the development of human cancers. To date, its expression pattern, biological function, and potential mechanism in pancreatic cancer have not been explored. In this study, we analyzed Rab14 expression in 103 cases of pancreatic cancer tissues using immunohistochemistry (IHC) and found that Rab14 was overexpressed in 41/103 cases (39.8%). Rab14 overexpression correlated with the advanced stage. Moreover, elevated Rab14 levels indicated poor prognosis of patients with pancreatic cancers...
September 29, 2018: Virchows Archiv: An International Journal of Pathology
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