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Virchows Archiv: An International Journal of Pathology

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https://www.readbyqxmd.com/read/28547535/middle-ear-adenomatous-neuroendocrine-tumors-a-25-year-experience-at-md-anderson-cancer-center
#1
Diana Bell, Adel K El-Naggar, Paul W Gidley
Neuroendocrine tumors are extremely rare in the middle ear. We reviewed our institutional experience with middle ear adenomatous neuroendocrine tumors (MEANTs). We searched our institution's pathology files to identify patients treated from 1990 to 2015 who had lesions classified as middle ear adenomas, adenomatous tumors, adenomatous tumors with neuroendocrine differentiation, carcinoid tumors of the middle ear, low-grade neuroendocrine tumors of the middle ear, and neuroendocrine carcinomas of the middle ear and identified 14 such patients for whom follow-up information was available...
May 26, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28540450/high-neuronatin-nnat-expression-is-associated-with-poor-outcome-in-breast-cancer
#2
Norbert Nass, Sarah Walter, Dörthe Jechorek, Christine Weissenborn, Atanas Ignatov, Johannes Haybaeck, Saadettin Sel, Thomas Kalinski
Neuronatin (NNAT) is a proteolipid involved in cation homeostasis especially in the developing brain. Its expression has been associated with the progression of lung cancer, glioblastoma, and neuroblastoma as well as glucose induced apoptosis in pancreatic cells. We performed a retrospective study of 148 breast cancer specimens for NNAT expression by immunohistochemistry to evaluate this protein as a prognostic marker for breast cancer. We found a high NNAT immunoreactivity score (by multivariate cox regression) to be an independent prognostic marker for relapse-free (hazard ratio HR = 3...
May 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28540449/epidermoid-cysts-are-a-characteristic-feature-of-intrapancreatic-but-not-of-extrapancreatic-accessory-spleens
#3
Kenichi Hirabayashi, Misuzu Yamada, Hirotaka Kono, Atsuko Hadano, Aya Kawanishi, Yumi Takanashi, Yoshiaki Kawaguchi, Toshio Nakagohri, Tetsuya Mine, Naoya Nakamura
Accessory spleens (ASs), ectopic splenic tissue at intrapancreatic and extrapancreatic sites, rarely contain epidermoid cysts. Our aim was to analyze the incidence of epidermoid cysts in ASs and perform an immunohistochemical analysis of its epithelial lining. We included in the study 148 ASs from 135 patients, for which pathological data were available. Eleven were intrapancreatic ASs (IPASs) and 137 were extrapancreatic ASs (EPASs). Six of the eleven (55%) IPASs contained epidermoid cysts, but they were not detected in EPASs...
May 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28536779/the-association-between-microsatellite-instability-and-lymph-node-count-in-colorectal-cancer
#4
Alexander Arnold, Matthias Kloor, Lina Jansen, Jenny Chang-Claude, Hermann Brenner, Moritz von Winterfeld, Michael Hoffmeister, Hendrik Bläker
The number of lymph nodes retrieved from colorectal cancer (CRC) resection specimens is crucial for adequate diagnosis and therapy. Previous studies indicate that in addition to the extent of surgical resection and the quality of pathological lymph node examination, non-modifiable tumour parameters like microsatellite instability (MSI) are associated with higher lymph node count. In order to study the potential influence of MSI on lymph node count, we analysed a previously MSI-typed population of CRC patients (n = 1196) to determine the relationship between MSI and the frequency with which at least 12 lymph nodes were retrieved, as well as the mean and median number of retrieved lymph nodes...
May 23, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28528511/met-overexpression-and-gene-amplification-prevalence-clinico-pathological-characteristics-and-prognostic-significance-in-a-large-cohort-of-patients-with-surgically-resected-nsclc
#5
William Sterlacci, Michael Fiegl, Mathias Gugger, Lukas Bubendorf, Spasenija Savic, Alexandar Tzankov
The prevalence of overexpression and amplification of the proto-oncogene mesenchymal epithelial transition (MET) in non-small cell lung cancer (NSCLC) varies greatly in the literature. Since MET is a potential treatment target, knowledge of its prevalence and prognostic importance is crucial. We investigated MET expression and gene status in 735 NSCLC cases using tissue microarrays. Prognostic significance as well as correlations with various clinico-pathological parameters were evaluated. The prevalence of MET overexpression was 17% and MET amplification was present in 2...
May 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28528510/immunogenomics-using-genomics-to-personalize-cancer-immunotherapy
#6
Rance C Siniard, Shuko Harada
While the use of genomic data has the potential to revolutionize patient care, there is still much work to be done with regard to the transformation of host-tumor interactions into favorable clinical outcomes for our patients. High-throughput technologies, such as next-generation sequencing (NGS), have rapidly advanced our understanding of oncology, and we are learning that most tumors do not simply possess consistently mutated genes that are responsible for tumorigenesis, facilitating the need for personalized cancer therapy...
May 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28528509/invasive-lobular-carcinoma-with-extracellular-mucin-production-a-novel-pattern-of-lobular-carcinomas-of-the-breast-clinico-pathological-description-of-eight-cases
#7
Gábor Cserni, Giuseppe Floris, Nektarios Koufopoulos, Anikó Kovács, Afroditi Nonni, Peter Regitnig, Anders Stahls, Zsuzsanna Varga
Invasive lobular carcinoma of the breast is known to produce intracellular mucin and has been recognized in single-case reports to show extracellular mucin production, as well. This latter morphology is not only rare but must also be under- or misdiagnosed. The aim was to better characterize this entity. Cases of lobular cancers demonstrating extracellular mucin formation were identified in a multi-institutional effort and their clinical and morphologic features were assessed. Immunohistochemistry was used to characterize the E-cadherin-membrane complex, neuroendocrine differentiation, and to some extent, mucin formation...
May 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28516197/optimized-immunohistochemistry-using-the-d5f3-antibody-provides-a-reliable-test-for-identification-of-alk-positive-lung-adenocarcinomas
#8
Gian Luca Rampioni Vinciguerra, Stefania Scarpino, Benedetto Pini, Claudia Cippitelli, Flavio Fochetti, Luigi Ruco
We used optimized immunohistochemistry (IHC) with the D5F3 antibody for detection of tumours in a prospective study of 307 pulmonary adenocarcinomas. Cases positive by IHC (1+, 2+, 3+) were further investigated by fluorescent in situ hybridization (FISH). Of 307 cases, 22 (7.2%) were moderately intensely positive (2+/3+); 18 of these (82%) were also positive by FISH. Of the four IHC-positive/FISH-negative cases, one was unsuitable for FISH and three had abnormalities of the ALK gene. All cases with weak reactivity with D5F3 (1+) were FISH-negative...
May 17, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28512674/preparing-pathology-for-precision-medicine-challenges-and-opportunities
#9
Karen L Kaul
No abstract text is available yet for this article.
May 16, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28501935/early-gastric-adenocarcinoma-arising-within-foveolar-type-dysplasia-in-a-patient-with-muir-torre-variant-lynch-syndrome
#10
Tristan F P McKnight, Amy E Noffsinger, Kara M Klingman, Ovais Ahmed, Rebecca Wilcox
No abstract text is available yet for this article.
May 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28497316/quality-assurance-trials-for-ki67-assessment-in-pathology
#11
M Raap, S Ließem, J Rüschoff, A Fisseler-Eckhoff, A Reiner, S Dirnhofer, R von Wasielewski, H Kreipe
Ki67 is a broadly used proliferation marker in surgical pathology with an obvious need for standardization to improve reproducibility of assessment. Here, we present results of the so far only existing round robin tests on Ki67, organized annually in Germany, Austria, and Switzerland from 2010 to 2015 with up to 160 participating laboratories (QuIP). In each quality assessment trial, eight probes from each breast cancer, neuroendocrine tumor, and malignant lymphoma were compiled on a tissue microarray (TMA)...
May 11, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28488172/clear-cell-renal-cell-carcinoma-a-comparative-study-of-histological-and-chromosomal-characteristics-between-primary-tumors-and-their-corresponding-metastases
#12
Julien Dagher, Solène-Florence Kammerer-Jacquet, Frédéric Dugay, Marion Beaumont, Alexandra Lespagnol, Laurence Cornevin, Grégory Verhoest, Karim Bensalah, Nathalie Rioux-Leclercq, Marc-Antoine Belaud-Rotureau
Clear cell renal cell carcinoma (ccRCC) has a poor prognosis with a 50% risk of metastases. Little is known about the phenotypic and molecular profiles of metastases regarding their corresponding primary tumors. This study aimed to screen phenotypic and genotypic differences between metastases and their corresponding primary tumors. We selected four cases with available frozen material. The histological, immunohistochemical (VEGFA, CD31, SMA, Ki67, p53, PAR-3), FISH (VHL gene), next-generation sequencing (VHL and c-MET genes), multiplex ligation-dependent probe amplification, and array-(comparative genomic hybridization) CGH analyses were realized...
May 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28488171/clinical-and-pathological-characteristics-of-gastrointestinal-stromal-tumor-gist-metastatic-to-bone
#13
Kemal Kosemehmetoglu, Gulsah Kaygusuz, Karen Fritchie, Ovgu Aydin, Ozlem Yapicier, Oznur Coskun, Ersin Karatayli, Senay Boyacigil, Gulnur Guler, Sergulen Dervisoglu, Isinsu Kuzu
Our aim in this study was to describe the clinical, morphological, and molecular profile of gastrointestinal stromal tumor (GIST) metastatic to bone. We analyzed the morphological, phenotypic, and molecular characteristics of seven cases, and in addition reviewed 17 cases from literature. Sequence analysis of KIT and PDGFRA genes was possible for six cases. For the GIST cases with bone metastasis, the most common primaries were small intestine (29%), stomach (25%), and rectum (21%). Sites of bone metastases were vertebrae (11), pelvis (8), femur (8), ribs (6), humerus (5), skull (3), scapula (1), and mandible (1)...
May 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28488170/prognostic-role-of-bap1-in-pt1-clear-cell-carcinoma-in-partial-nephrectomy-specimens
#14
Daniele Minardi, Guendalina Lucarini, Giulio Milanese, Rodolfo Montironi, Roberto Di Primio
BAP1 is a gene situated on chromosome 3p in a region that can be modified in renal cell carcinomas (RCCs). Mutations that cause loss of expression of BAP1 frequently occur in primary clear cell renal carcinoma (ccRCC). In a previous work, we observed that loss of nuclear BAP1 expression was crucial in ccRCC progression; in the current study, we investigated BAP1 expression in a large series of small conventional ccRCCs treated with partial nephrectomy, to assess a possible role as biomarker and the prognostic value in terms of patients' survival at long-term follow-up...
May 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28484843/hoxb13-a-useful-marker-in-pleomorphic-giant-cell-adenocarcinoma-of-the-prostate-a-case-report-and-review-of-the-literature
#15
Laura Larnaudie, Eva Compérat, Pierre Conort, Justine Varinot
We report the case of an 81-year-old patient with a pleomorphic giant cell adenocarcinoma of the prostate. After diagnosis, he rapidly developed bone metastasis and died within 1 year. This variant of acinar adenocarcinoma is extremely rare and prognosis is poor. This entity has been included into the 2016 WHO classification. The principal differential diagnosis is urothelial carcinoma. To assess the prostatic origin, routine immunohistochemistry can be problematic. Loss of epitopes in this poorly differentiated entity can occur, such as loss of expression of PSA and p504s...
May 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28477272/hif-1%C3%AE-mdm2-cdk4-and-p16-expression-in-ischemic-fasciitis-focusing-on-its-ischemic-condition
#16
Yuichi Yamada, Izumi Kinoshita, Kenichi Kohashi, Hidetaka Yamamoto, Yuki Kuma, Takamichi Ito, Kenji Koda, Atsushi Kisanuki, Manabu Kurosawa, Michiko Yoshimura, Masutaka Furue, Yoshinao Oda
Ischemic fasciitis is a benign myofibroblastic lesion, occurring in the sacral region or proximal thigh of elderly or bedridden individuals. The pathogenesis of ischemic fasciitis is thought to be based on ischemic condition; however, it has never been demonstrated. In this study, we examined the expression of ischemia-associated proteins in ischemic fasciitis by immunohistochemical and genetic methods. Specifically, this study aimed to reveal the expression of HIF-1α, MDM2, CDK4, p16, and gene amplification of MDM2 gene...
May 6, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28474092/intravascular-large-b-cell-lymphoma-diagnosed-in-random-duodenal-biopsies-a-case-report-and-a-literature-review
#17
Yevgeniy Linnik, Janne Rand, Prabhjot Kaur, Xiaoying Liu
No abstract text is available yet for this article.
May 4, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28474091/cardiac-intimal-sarcoma-with-pdgfr%C3%AE-mutation-and-co-amplification-of-pdgfr%C3%AE-and-mdm2-an-autopsy-case-analyzed-by-whole-exome-sequencing
#18
Yukinobu Ito, Daichi Maeda, Makoto Yoshida, Akihiko Yoshida, Yukitsugu Kudo-Asabe, Hiroshi Nanjyo, Chikako Izumi, Fumio Yamamoto, Masahiro Inoue, Hiroyuki Shibata, Hiroto Katoh, Shumpei Ishikawa, Hiromi Nakamura, Yasushi Totoki, Tatsuhiro Shibata, Shinichi Yachida, Akiteru Goto
No abstract text is available yet for this article.
May 4, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28466157/liquid-biopsy-unlocking-the-potentials-of-cell-free-dna
#19
David Chu, Ben Ho Park
Circulating tumor DNA (ctDNA) has garnered much excitement over the past few years for its potential clinical utility as a surrogate for tumor biopsies in early cancer detection and prognosis. Numerous studies have demonstrated that ctDNA is shed into the circulation and is elevated in disease states such as cancer. Despite the low levels of ctDNA in the "sea" of normal DNA, advances in next generation sequencing (NGS) and digital polymerase chain reaction (PCR) technologies have led to dramatic improvements in variant detection sensitivity and specificity...
May 2, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28466156/mirna-regulation-is-important-for-dna-damage-repair-and-recognition-in-malignant-pleural-mesothelioma
#20
Fabian Dominik Mairinger, Robert Werner, Elena Flom, Jan Schmeller, Sabrina Borchert, Michael Wessolly, Jeremias Wohlschlaeger, Thomas Hager, Thomas Mairinger, Jens Kollmeier, Daniel Christian Christoph, Kurt Werner Schmid, Robert Fred Henry Walter
Platin-containing regimes are currently considered as state-of-the-art therapies in malignant pleural mesotheliomas (MPM) but show dissatisfying response rates ranging from 6 to 16% only. Still, the reasons for the rather poor efficacy remain largely unknown. A clear stratification of patients based on new biomarkers seems to be a promising approach to enhance clinical management, which would be a long-needed improvement for MPM patients but does not seem likely soon unless new biomarkers can be validated. Twenty-four formalin-fixed, paraffin-embedded (FFPE) tumour specimens were subjected to a miRNA expression screening of 800 important miRNAs using digital quantification via the nCounter technique (NanoString)...
May 2, 2017: Virchows Archiv: An International Journal of Pathology
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