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Virchows Archiv: An International Journal of Pathology

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https://www.readbyqxmd.com/read/30030621/scoring-the-tumor-stroma-ratio-in-colon-cancer-procedure-and-recommendations
#1
G W van Pelt, S Kjær-Frifeldt, J H J M van Krieken, R Al Dieri, H Morreau, R A E M Tollenaar, F B Sørensen, W E Mesker
The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic parameter in colon cancer as well as in other epithelial cancer types, and may be implemented to routine pathology diagnostics. The TSR is an easy technique, based on routine hematoxylin and eosin stained histological sections, estimating the amount of stroma present in the primary tumor. It links tumors with high stromal content to poor prognosis. The analysis time is less than 2 min with a low inter-observer variation. Scoring of the TSR has been validated in a number of independent international studies...
July 20, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30014289/dendriform-pulmonary-ossification-leading-to-bilateral-lung-transplant-a-case-report
#2
John M Carney, Joseph G Mammarappallil, Thomas A Sporn, Elizabeth N Pavlisko
Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossification within the alveolar septa is a rare entity. Similarly, it is unusual to see overt, diffuse disease affecting the lung to the point of respiratory failure leading to lung transplant. We present a case of an adult male who underwent bilateral lung transplantation, with the native lung pathology showing diffuse, severe dendriform ossification of the bilateral upper and lower lung lobes...
July 17, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30014288/immunohistochemistry-for-pax7-is-a-useful-confirmatory-marker-for-ewing-sarcoma-in-decalcified-bone-marrow-core-biopsy-specimens
#3
Sebastian Fernandez-Pol, Matt van de Rijn, Yasodha Natkunam, Gregory W Charville
PAX7 has been recently demonstrated to be a highly sensitive marker for Ewing sarcoma, and thus far has only been shown to label a relatively small set of other mesenchymal neoplasms. Because the processing of bone marrow core biopsies can often hinder the performance of immunohistochemical stains, we set out to determine if our laboratory's PAX7 staining protocol effectively detects Ewing sarcoma in Bouin's fixed, decalcified bone marrow core biopsies. We stained ten core biopsies involved by Ewing sarcoma, nine non-involved core biopsies, and 13 core biopsies involved by histologic mimics of Ewing sarcoma...
July 17, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30006753/differential-expression-of-e-cadherin-and-p-cadherin-in-pt3-prostate-cancer-correlation-with-clinical-and-pathological-features
#4
Catarina Ferreira, João Lobo, Luís Antunes, Paula Lopes, Carmen Jerónimo, Rui Henrique
Cadherins seem to play and important role in prostate cancer (PCa) progression. E-cadherin loss of expression has been associated with poor prognosis; P-cadherin's role is still elusive. Although pT3 PCa is often considered "high-risk cancer," it does not exhibit an uniformly poor prognosis. Herein, we assessed the prognostic value and survival impact of E-cadherin and P-cadherin immunoexpression in pT3 PCa. Radical prostatectomy (RP) specimens from 102 pT3 PCa patients treated between 1991 and 2014 in a single institution were designated for E-cadherin and P-cadherin immunoexpression analysis...
July 13, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30003325/incidentally-detected-pancreatic-neuroendocrine-microadenoma-with-lymph-node-metastasis
#5
Jeong-Hwa Kwon, Hyoung Jung Kim, Do Hyun Park, Young-Joo Lee, Christopher M Heaphy, Günter Klöppel, Ralph H Hruban, Seung-Mo Hong
Pancreatic neuroendocrine microadenomas (NEMAs) are non-functioning neuroendocrine tumors < 0.5 cm with a low proliferation rate and are considered benign. We report on a pancreatic NEMA with lymph node metastasis. A male in his 70s had pylorus-preserving pancreaticoduodenectomy for a distal bile duct carcinoma, which was a 2.1 cm well-differentiated-infiltrating adenocarcinoma with invasion limited to the bile duct wall. An incidental separate 0.4 cm well-differentiated NEMA was found in the pancreatic head with metastatic well-differentiated neuroendocrine tumor in one peripancreatic lymph node...
July 12, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29998424/primary-small-bowel-adenomas-and-adenocarcinomas-recent-advances
#6
REVIEW
Aoife Maguire, Kieran Sheahan
The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive system cancers occur at this site. Adenocarcinoma accounts for half of small bowel malignancies. There have been a number of important recent advances in our understanding, classification and treatment of small bowel tumours. Over recent years, ampullary tumours have become recognised as a form of small bowel carcinoma, distinct from head of pancreas and lower biliary tract tumours...
July 11, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29987614/eosinophils-in-the-gastrointestinal-tract-how-much-is-normal
#7
Jorge Silva, Pedro Canão, Maria Céu Espinheira, Eunice Trindade, Fátima Carneiro, Jorge Amil Dias
The normal density of eosinophils in the digestive mucosa of children has been rarely addressed despite being important to provide baseline counts for the diagnosis of eosinophilic gastrointestinal disorders (EGID). Histopathological criteria for EGID remain undefined and there has been little consistency of results in different populations. We aimed to establish the eosinophil density of the normal digestive mucosa in a paediatric population submitted to endoscopic procedures with normal histological features...
July 10, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29984379/histological-changes-secondary-to-wire-coil-placement-in-breast-tissue-and-lymph-nodes
#8
Ignacio Pinilla-Pagnon, Belén Pérez-Mies, María Eugenia Reguero, Marco-Tulio Martinez, Miguel Chiva, Silvia Pérez-Rodrigo, Odile Ajuria Illarramendi, Maria Eugenia Rioja Martin, Maria Vicenta Collado, Maria Concepción Sanchez, Juan Manuel Rosa-Rosa, José Palacios
We describe the histological and immunohistochemical features of the changes produced by spiral coil localization wires in the breast parenchyma and lymph nodes of a total of 100 patients undergoing surgery for different breast lesions. Coil wires produced cystic lesions containing a hyaline, mucous-like, PAS-negative fluid. Cavities were lined by cells of variable morphology ranging from synovial-like cells (with a conspicuous epithelial appearance) to mononuclear or multinucleate histiocytic cells that expressed CD68, but were negative for keratins...
July 8, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29984378/head-and-neck-manifestations-of-an-undiagnosed-mccune-albright-syndrome-clinicopathological-description-and-literature-review
#9
Beatriz Lecumberri, José Juan Pozo-Kreilinger, Isabel Esteban, Mariana Gomes, Aránzazu Royo, Álvaro Gómez de la Riva, Guiomar Pérez de Nanclares
Craniofacial fibrous dysplasia, characteristic of McCune-Albright syndrome (MAS), is usually present in patients with MAS-related acromegaly. We report here the first case of a patient with an undiagnosed MAS presenting with an acute hydrocephalus. A 21-year-old male with gigantism and craniofacial fibrous dysplasia consulted for rapidly progressive headache. An acute obstructive hydrocephalus due to a 39 × 35-mm cystic lesion in the third ventricle was discovered and operated, obtaining hydrocephalus resolution...
July 8, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29980856/response-to-aberrant-expression-of-tdt-in-seminomatous-germ-cell-neoplasia
#10
LETTER
Alexander Brobeil, Florian Wagenlehner, Stefan Gattenlöhner
No abstract text is available yet for this article.
July 6, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29968181/aberrant-expression-of-tdt-in-seminomatous-germ-cell-neoplasia
#11
LETTER
Matthew George Gayhart, Hope Richard, Austin Blackburn Wiles, Steven Christopher Smith
No abstract text is available yet for this article.
July 3, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29951866/novel-steps-forward-in-the-histopathology-of-non-celiac-gluten-sensitivity-authors-reply
#12
LETTER
Barbara Zanini, Vincenzo Villanacci, Monica Marullo, Moris Cadei, Francesco Lanzarotto, Anna Bozzola, Chiara Ricci
No abstract text is available yet for this article.
June 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29938394/neuroendocrine-tumor-of-the-pancreas-with-rhabdoid-feature
#13
Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, Yuichiro Kubo, Yasuhiro Ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Takao Ohtsuka, Masafumi Nakamura, Yoshinao Oda
Imaging of a 53-year-old Japanese man revealed two tumors in the liver and a tumor in the head of the pancreas with a swelling lymph node. A needle biopsy for the liver tumors was performed, revealing a neuroendocrine tumor. Enucleation, lymphadenectomy, and partial hepatectomy were performed. The microscopic examination identified many tumor cells with intracytoplasmic inclusions arranged in a nested, cord, or tubular fashion. The intracytoplasmic inclusions displayed densely eosinophilic globules and displaced the nuclei toward the periphery, which constitutes "rhabdoid" features...
June 24, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29934658/letter-to-the-editor-reply-to-valeria-barresi-hoxb13-is-not-expressed-in-pleomorphic-giant-cell-carcinoma-of-the-bladder
#14
LETTER
Justine Varinot, Eva Compérat
No abstract text is available yet for this article.
June 22, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29934657/a-case-of-multiple-familial-trichoepitheliomas-responding-to-treatment-with-the-hedgehog-signaling-pathway-inhibitor-vismodegib
#15
Vera Baur, Thomas Papadopoulos, Dmitry V Kazakov, Abbas Agaimy, Arndt Hartmann, Georg Isbary, Ralph M Wirtz, Erwin S Schultz
Multiple familial trichoepitheliomas (MFT) is an autosomal dominantly inherited disease characterized by multiple skin appendage tumors. We describe a patient showing a continuous spectrum of follicular differentiated neoplasms including classical trichoepitheliomas but also infiltrative growing and finally metastasizing malignant follicular differentiated tumors. Germline mutation analysis revealed a nonsense mutation in the cylindromatosis (CYLD) gene. Gene expression analysis by real-time PCR of tumor tissue showed overexpression of glioma-associated oncogene Gli1 mRNA...
June 22, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29931470/how-to-standardize-the-evaluation-of-tumor-regression-grading-of-gastrointestinal-cancers-after-neoadjuvant-therapy
#16
LETTER
Anna Nasierowska-Guttmejer, Andrzej Szawłowski
No abstract text is available yet for this article.
June 21, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29931469/cytogenetic-and-immunohistochemical-study-of-42-pigmented-microcystic-chromophobe-renal-cell-carcinoma-pmchrcc
#17
Francisco Javier Queipo Gutiérrez, Ángel Panizo, Antonio Tienza, Irene Rodriguez, Jesús Javier Sola, Jordi Temprana-Salvador, Inés de Torres, Javier Pardo-Mindán
Pigmented microcystic chromophobe renal cell carcinoma (PMChRCC) is a recently described morphologic variant of ChRCC. We have identified 42 cases in 40 patients in the last 24 years. We have investigated their clinical, morphologic, immunohistochemical, and cytogenetic features. Chromosomal abnormalities of chromosomes 7 and 17 were evaluated by automated dual-color silver-enhanced in situ hybridization on paraffin-embedded tissue. Chromosomal imbalance was defined on the basis of changes in both chromosomal index and signal distribution...
June 21, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29926186/reply-to-the-letter-how-to-standardize-the-evaluation-of-tumor-regression-grading-of-gastrointestinal-cancers-after-neoadjuvant-therapy-by-dr-nasierowska-guttmejer-and-dr-szawlowski-viar-d-18-00181
#18
LETTER
Rupert Langer, Karen Becker
No abstract text is available yet for this article.
June 21, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29926185/hoxb13-is-not-expressed-in-pleomorphic-giant-cell-carcinoma-of-the-bladder
#19
LETTER
Valeria Barresi
No abstract text is available yet for this article.
June 21, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29926184/comparison-of-targeted-next-generation-sequencing-ngs-versus-isolated-braf-v600e-analysis-in-patients-with-metastatic-melanoma
#20
Meng-Lei Zhu, Lan Zhou, Navid Sadri
Molecular testing on advanced metastatic melanoma is critical for guiding targeted therapy. Traditionally, this analysis has relied on isolated BRAF V600E analysis; however, more recently targeted next generation sequencing (NGS) is being utilized. The clinical utility of BRAF V600E allele-specific PCR and targeted NGS were compared for metastatic melanoma samples sent to UHCMC pathology during a two and half year span. In two thirds of cases, negative for BRAF V600E, additional mutations were detected that may stratify patients for potential or approved targeted therapies...
June 21, 2018: Virchows Archiv: An International Journal of Pathology
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