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Virchows Archiv: An International Journal of Pathology

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https://www.readbyqxmd.com/read/28733884/paediatric-hepatocellular-carcinoma-in-tight-junction-protein-2-tjp2-deficiency
#1
Mukul Vij, Naresh P Shanmugam, Mettu Srinivas Reddy, Srinivas Sankaranarayanan, Mohamed Rela
No abstract text is available yet for this article.
July 21, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28730538/spectrum-of-lesions-derived-from-branchial-arches-occurring-in-the-thyroid-from-solid-cell-nests-to-tumors
#2
Kristyna Srbecka, Kvetoslava Michalova, Radmila Curcikova, Michael Michal, Magdalena Dubova, Marian Svajdler, Michal Michal, Ondrej Daum
There is a group of lesions in the head and neck region derived from branchial arches and related structures which, when inflamed, are characterized by the formation of cysts lined by squamous or glandular epithelium and surrounded by a heavy inflammatory infiltrate rich in germinal centers. In the thyroid, the main source of various structures which may cause diagnostic dilemma is the ultimobranchial body. To investigate the spectrum of such thyroid lesions, the consultation files were reviewed for thyroid samples containing pathological structures regarded to arise from the ultimobranchial body...
July 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28730537/lung-cancer-as-a-paradigm-for-precision-oncology-in-solid-tumours
#3
Simon Schallenberg, Sabine Merkelbach-Bruse, Reinhard Buettner
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the western world. However, the combination of molecular genotyping and subsequent systematic treatment of decoded target structures is a prime example of precision oncology in solid tumours. In this review, current targets of approved therapeutics and potential targets in clinical and preclinical trials are outlined. Furthermore, immune checkpoint inhibitors, as promising new therapeutic options, which have already been applied successfully in cases of lung cancer, are introduced...
July 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28725929/inverse-correlation-between-galectin-4-and-ttf-1-in-lung-adenocarcinoma
#4
Kieko Hara, Tsuyoshi Saito, Takuo Hayashi, Keiko Mitani, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki, Takashi Yao
We have previously shown that galectin-4 expression is an independent predictor for lymph node metastasis and serves as an adverse prognostic indicator in patients with acinar adenocarcinoma of the lung. In contrast, thyroid transcription factor-1 (TTF-1) expression in non-small cell lung carcinoma has been shown to be associated with a favorable prognosis. In the present study, 208 cases of acinar adenocarcinoma of the lung and 36 cases with distant metastatic lesions of lung adenocarcinoma were immunohistochemically examined for expression of galectin-4 and TTF-1 to elucidate their correlation with clinicopathological factors...
July 19, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28721490/foxa1-and-ck14-as-markers-of-luminal-and-basal-subtypes-in-histologic-variants-of-bladder-cancer-and-their-associated-conventional-urothelial-carcinoma
#5
Joshua I Warrick, Matthew Kaag, Jay D Raman, Wilson Chan, Truc Tran, Sudhir Kunchala, Lauren Shuman, David DeGraff, Guoli Chen
Invasive bladder cancer is diverse, and includes several named histomorphologies that differ from conventional urothelial carcinoma, termed "histologic variants." By transcriptional analysis, bladder cancers can be divided into luminal and basal subtypes. In this paper, we study associations between markers of transcriptional subtypes and variant histology in a retrospective cohort of 309 cystectomy specimens. Histology slides were methodically reviewed for all cases, and variant histology was documented. Immunohistochemistry for FOXA1 (luminal marker) and CK14 (basal maker) was performed on histologic variants and their associated conventional urothelial carcinomas...
July 18, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28721489/quality-in-pathology
#6
EDITORIAL
J H J M van Krieken
No abstract text is available yet for this article.
July 18, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28718031/newcomers-in-paediatric-gi-pathology-childhood-enteropathies-including-very-early-onset-monogenic-ibd
#7
Arzu Ensari, Judith Kelsen, Pierre Russo
Childhood enteropathies are a group of diseases causing severe chronic (>2-3 weeks) diarrhoea often starting in the first week of life with the potential for fatal complications for the affected infant. Early identification and accurate classification of childhood enteropathies are, therefore, crucial for making treatment decisions to prevent life-threatening complications. Childhood enteropathies are classified into four groups based on the underlying pathology: (i) conditions related to defective digestion, absorption and transport of nutrients and electrolytes; (ii) disorders related to enterocyte differentiation and polarization; (iii) defects of enteroendocrine cell differentiation; and (iv) disorders associated with defective modulation of intestinal immune response...
July 17, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28714037/preparing-pathology-for-the-molecular-era
#8
EDITORIAL
Fred T Bosman, George J Netto
No abstract text is available yet for this article.
July 17, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28711990/assessment-of-braf-v600e-mutation-in-pulmonary-langerhans-cell-histiocytosis-in-tissue-biopsies-and-bronchoalveolar-lavages-by-droplet-digital-polymerase-chain-reaction
#9
Clémence Pierry, Charline Caumont, Elodie Blanchard, Camille Brochet, Gael Dournes, Audrey Gros, Thomas Bandres, Séverine Verdon, Marion Marty, Hugues Bégueret, Jean-Philippe Merlio
The neoplastic nature of pulmonary Langerhans cell histiocytosis (PLCH) is still debated. As the detection of BRAF (V600E) and MAP2K1 mutations in patients with PCLH is now considered for such assessment, the aim of our study was to evaluate digital droplet polymerase chain reaction (ddPCR) in PCLH diagnosis. We retrospectively analyzed BRAF(V600E) detection in a cohort of 42 PCLH tissues and 18 bronchoalveolar lavages (BALs) by ddPCR, immunohistochemistry, high-resolution melting PCR (HRM), and next-generation sequencing (NGS)...
July 15, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28707056/comparison-of-oncotype-dx%C3%A2-recurrence-score%C3%A2-with-other-risk-assessment-tools-including-the-nottingham-prognostic-index-in-the-identification-of-patients-with-low-risk-invasive-breast-cancer
#10
Maura Bríd Cotter, Alex Dakin, Aoife Maguire, Janice M Walshe, M John Kennedy, Barbara Dunne, Ciarán Ó Riain, Cecily M Quinn
Oncotype DX® is a gene expression assay that quantifies the risk of distant recurrence in patients with hormone receptor positive early breast cancer, publicly funded in Ireland since 2011. The aim of this study was to correlate Oncotype DX® risk groupings with traditional histopathological parameters and the results of other risk assessment tools including Recurrence Score-Pathology-Clinical (RSPC), Adjuvant Risk Index (Adj RI), Nottingham Prognostic Index (NPI) and the Adjuvant! Online 10-year score (AO)...
July 14, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28707055/histological-heterogeneity-in-primary-and-metastatic-classic-combined-hepatocellular-cholangiocarcinoma-a-case-series
#11
Claudio De Vito, Debashis Sarker, Paul Ross, Nigel Heaton, Alberto Quaglia
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare and aggressive primary liver cancer with both hepatocellular and cholangiocellular differentiation. Due to its bi-phenotypic component, cHCC-CC is a heterogeneous tumour and histopathological analysis of metastatic deposits is poorly characterized. In this retrospective study, we describe four patients in whom the histology from resected specimens of both primary and recurrent and/or metastatic tumour was available for comparison and immunohistochemical characterization...
July 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28702779/clinicopathological-characteristics-of-fallopian-tube-metastases-from-primary-endometrial-cervical-and-nongynecological-malignancies-a-single-institutional-experience
#12
Kiyong Na, Hyun-Soo Kim
This study was aimed at investigating the clinicopathological characteristics of tubal metastases originating from primary endometrial, cervical, and nongynecological malignancies. We performed a 4-year retrospective study in which fallopian tube tissues obtained from 60 patients with tubal metastases were examined. In addition, we compared the number of tubal metastasis cases detected during periods of representative or whole tubal sampling. Twenty-three and 37 tubal metastases were found in cases examined after representative and whole tubal sampling techniques, respectively...
July 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28702778/characterization-of-her2-gene-amplification-heterogeneity-in-invasive-and-in-situ-breast-cancer-using-bright-field-in-situ-hybridization
#13
António Polónia, Guilherme Oliveira, Fernando Schmitt
The aims of this study were to evaluate and compare the HER2 gene amplification status in invasive and adjacent in situ breast carcinoma, using bright-field in situ hybridization, and to document the possible presence of HER2 genetic heterogeneity (HER2-GH) in both components. A cohort of 100 primary invasive carcinomas (IC) associated with carcinoma in situ (CIS) were evaluated for HER2 gene amplification by SISH according to the 2013 ASCO/CAP HER2 guideline. A second cohort of all the cases with HER2-GH since the introduction of the updated ASCO/CAP HER2 guideline was also characterized, and an evaluation of the HER2 gene amplification in the CIS component, if present, was also done...
July 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28702777/a-cell-line-thought-to-represent-mucinous-breast-cancer-probably-represents-lobular-carcinoma-with-extracellular-mucin-production
#14
LETTER
Gábor Cserni
No abstract text is available yet for this article.
July 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28699109/malignant-mesenchymal-neoplasms-of-the-dermis-and-subcutis-mimicking-benign-lesions-a-case-based-review
#15
Thomas Mentzel, Thomas Brenn
In this short review, malignant mesenchymal neoplasms of the dermis and subcutis mimicking benign lesions and their differential diagnoses are discussed. These include plaque-like dermatofibrosarcoma protuberans, superficial low-grade fibromyxoid sarcoma, low-grade superficial malignant peripheral nerve sheath tumour, epithelioid sarcoma, pseudomyogenic haemangioendothelioma, Kaposi sarcoma mimicking cavernous haemangioma and benign lymphangioendothelioma, and rare forms of angiosarcoma mimicking a benign vascular lesion...
July 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28699108/the-role-of-epithelial-mesenchymal-transition-in-squamous-cell-carcinoma-of-the-oral-cavity
#16
Nina Zidar, Emanuela Boštjančič, Marija Malgaj, Nina Gale, Tadej Dovšak, Vojko Didanovič
Epithelial-mesenchymal transition (EMT) has emerged as a possible mechanism of cancer metastasizing, but strong evidence for EMT involvement in human cancer is lacking. Our aim was to compare oral spindle cell carcinoma (SpCC) as an example of EMT with oral conventional squamous cell carcinoma (SCC) with and without nodal metastases to test the hypothesis that EMT contributes to metastasizing in oral SCC. Thirty cases of oral SCC with and without nodal metastasis and 15 cases of SpCC were included. Epithelial (cytokeratin, E-cadherin), mesenchymal (vimentin, N-cadherin), and stem cell markers (ALDH-1, CD44, Nanog, Sox-2) and transcription repressors (Snail, Slug, Twist) were analyzed immunohistochemically...
July 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28699107/primary-pure-lymphoepithelioma-like-carcinoma-of-the-ureter
#17
LETTER
J Fernando Val-Bernal
No abstract text is available yet for this article.
July 11, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28695297/histiocytic-and-dendritic-cell-neoplasms-what-have-we-learnt-by-studying-67-cases
#18
Fabio Facchetti, Stefano Aldo Pileri, Luisa Lorenzi, Valentina Tabanelli, Lisa Rimsza, Stefania Pittaluga, Stephan Dirnhofer, Christiane Copie-Bergman, Laurence de Leval, Andreas Rosenwald, Andrew Wotherspoon, Falko Fend
Tumors derived from histiocytic and dendritic cells encompass a large and heterogeneous group of neoplastic and reactive conditions, and their diagnosis is challenging both for pathologists and clinicians. Diagnosis is based on morphological and phenotypical findings, but hybrid features are not uncommon. Furthermore, recent studies uncovered the molecular mechanisms driving some of these tumors, improving diagnostic adequacy, and providing the basis for effective therapeutic breakthroughs.Sixty-seven cases were submitted to the accessory cell and histiocytic neoplasms session at the European Association of Haematopathology/Society for Hematopathology workshop 2016 held in Basel, Switzerland...
July 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28689224/mixed-papillary-sarcomatoid-carcinoma-of-the-penis-report-of-an-aggressive-subtype
#19
Graziele Bovolim, Walter Henriques da Costa, Gustavo Cardoso Guimaraes, Fernando Augusto Soares, Isabela Werneck da Cunha
Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis. The association of two histological subtypes (mixed tumors) can be observed in one third of the cases. The most common association is of warty and basaloid tumors, two HPV-related carcinomas. Here, we described a mixed papillary-sarcomatoid carcinoma, never reported before. Although it is a clinical aspect of a low-grade verruciform tumor, its prognosis showed it to be very aggressive due to the sarcomatoid component hidden above the papillary component...
July 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28674742/characterization-of-gliomas-from-morphology-to-molecules
#20
Sean P Ferris, Jeffrey W Hofmann, David A Solomon, Arie Perry
This article reviews the histologic and molecular characterization of gliomas, including the new "integrated diagnoses" of the World Health Organization Classification, 2016 edition. The entities reviewed within include diffuse gliomas (astrocytoma, oligodendroglioma, glioblastoma), as well as circumscribed and low-grade gliomas (angiocentric glioma, pilocytic astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, pilomyxoid astrocytoma, ependymoma, myxopapillary ependymoma, and subependymoma)...
July 4, 2017: Virchows Archiv: An International Journal of Pathology
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