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Virchows Archiv: An International Journal of Pathology

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https://www.readbyqxmd.com/read/28444451/new-tumor-entities-in-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumors-nasal-cavity-paranasal-sinuses-and-skull-base
#1
REVIEW
Lester D R Thompson, Alessandro Franchi
The World Health Organization recently published the 4th edition of the Classification of Head and Neck Tumors, including several new entities, emerging entities, and significant updates to the classification and characterization of tumor and tumor-like lesions, specifically as it relates to nasal cavity, paranasal sinuses, and skull base in this overview. Of note, three new entities (NUT carcinoma, seromucinous hamartoma, biphenotypic sinonasal sarcoma,) were added to this section, while emerging entities (SMARCB1-deficient carcinoma and HPV-related carcinoma with adenoid cystic-like features) and several tumor-like entities (respiratory epithelial adenomatoid hamartoma, chondromesenchymal hamartoma) were included as provisional diagnoses or discussed in the setting of the differential diagnosis...
April 25, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28432432/tgf%C3%AE-splicing-and-canonical-pathway-activation-in-high-grade-serous-carcinoma
#2
Neriya Gutgold, Ben Davidson, Liora Jacobs Catane, Arild Holth, Ellen Hellesylt, Claes G Tropé, Anne Dørum, Reuven Reich
The present study analyzed the expression and clinical role of the transforming growth factor-β (TGFβ) pathway in high-grade serous carcinoma (HGSC), with focus on malignant effusions. TGFβ1-3 and TGFβRI-III mRNA expression by qRT-PCR was analyzed in 70 HGSC effusions and 55 solid specimens (28 ovarian, 27 abdominal metastases). Protein expression of Smad2 and Smad3 and their phosphorylated forms by Western blotting was analyzed in 73 specimens (42 effusions, 13 ovarian carcinomas, 18 solid metastases)...
April 21, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28429075/toward-personalized-management-in-bladder-cancer-the-promise-of-novel-molecular-taxonomy
#3
REVIEW
Marie-Lisa Eich, Lars Dyrskjøt, George J Netto
Empowered by the recent advances in next generation sequencing and bioinformatics technology, an unprecedented wave of integrated transcriptomic and genomic studies have impacted the field of bladder cancer. These studies not only have confirmed previously charted genetic pathways in bladder cancer development but also have led to the discovery of numerous additional crucial driver genetic alterations. As a result, a novel genomic-based taxonomy is emerging that promises to better define clinically relevant intrinsic subtypes of bladder cancer...
April 21, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28429074/ultrastructure-of-pheochromocytoma-undescribed-morphologic-features
#4
A Beiras Fernandez, A Kornberger, M Fraga, C F Vahl, A Beiras
We examined samples of human pheochromocytoma from 11 patients aged 30-70 years including one case of malignant pheochromocytoma with a view to identifying previously unreported ultrastructural details.We identified two types of nuclear inclusions consisting of irregularly shaped singular or multiple granulofibrillar formations with a typical concentric halo, on the one hand, and accumulations of egg-shaped structures consisting of granules and microfilaments, on the other. In some of the tumor cells, membrane-covered inclusions containing parallel laminar elements arranged in a paracrystalline, periodic fashion, or mega-mitrochondriae characterized by increased electrodensity of their matrix, and fibrillary material in the spaces between the cristae were present...
April 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28424866/histopathological-findings-of-extra-ileal-manifestations-at-initial-diagnosis-of-crohn-s-disease-related-ileitis
#5
LETTER
Ian S Brown, Gregory Miller, Mark L Bettington, Christophe Rosty
No abstract text is available yet for this article.
April 19, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28424865/immunostaining-for-hu-c-d-and-cd56-is-useful-for-a-definitive-histopathological-diagnosis-of-congenital-and-acquired-isolated-hypoganglionosis
#6
Koichiro Yoshimaru, Tomoaki Taguchi, Satoshi Obata, Junkichi Takemoto, Yoshiaki Takahashi, Tsuyoshi Iwanaka, Yusuke Yanagi, Masaaki Kuda, Kina Miyoshi, Toshiharu Matsuura, Yoshiaki Kinoshita, Takako Yoshioka, Atsuko Nakazawa, Yoshinao Oda
Isolated hypoganglionosis (IHG) has been proposed as a distinct entity with two subtypes: congenital IHG (CIHG) and acquired IHG (AIHG). However, due to the rarity of the disease and the lack of defining histological criteria, the concept of IHG is not widely accepted. We studied paraffin-embedded intestinal specimens from 79 patients diagnosed with Hirschsprung's disease (HD) (n = 49), CIHG (n = 25), and AIHG (n = 5) collected between January 1996 and December 2015. Histopathological diagnosis of HD, CIHG, and AIHG was confirmed by hematoxylin and eosin staining and immunohistochemical staining using Hu C/D and CD56...
April 19, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28421340/is-tumor-cellularity-in-primary-invasive-breast-carcinoma-of-prognostic-significance
#7
Emily S Reisenbichler, William Dupont, W Dale Plummer, Omar Hameed
Many methods of analysis to predict survival of invasive mammary carcinoma in the post-neoadjuvant setting utilize tumor cellularity alone or in combination with other tumor features. The goal of this study was to evaluate the prognostic value of tumor cellularity in primary non-treated carcinoma. We used 366 cases of invasive breast carcinoma to determine invasive tumor cellularity (%) by reviewing a representative excisional tumor section and correlated this with breast cancer recurrence (BCR) and overall mortality (OM)...
April 19, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28421339/small-bowel-adenocarcinoma-complicating-crohn-s-disease-a-single-centre-experience-emphasizing-the-importance-of-screening-for-dysplasia
#8
Chloé Grolleau, Nicolas M Pote, Nathalie S Guedj, Magaly Zappa, Nathalie Theou-Anton, Yoram Bouhnik, Yves Panis, Dominique L Cazals-Hatem
Small bowel adenocarcinoma (SBA) complicating Crohn's disease (CD) is rare and generally found incidentally on surgical specimens. We report our experience in CD-associated SBA observed this last decade in a tertiary referral centre in order to update its incidence, clinical presentation and pathological features. All SBAs diagnosed in patients who underwent surgery for CD between 2006 and 2016 were retrospectively included. Clinico-pathological characteristics were reviewed, and follow-up was updated. SBA was diagnosed in 9 (1...
April 18, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28417200/hpv-related-carcinomas-of-the-head-and-neck-morphologic-features-variants-and-practical-considerations-for-the-surgical-pathologist
#9
REVIEW
Todd M Stevens, Justin A Bishop
Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma is a distinct tumor entity with clinical, epidemiologic, genetic, histologic, prognostic, and treatment differences from smoking- and alcohol-related head and neck squamous cell carcinoma. This is now well known by the pathology and medical community. What is not yet widely known is that several emerging variants of HPV-related carcinoma of the head and neck exist apart from the prototypical non-keratinizing morphology. Further, there is currently considerable variation in methodologies used and clinical scenarios in which to test for HPV-related head and neck squamous cell carcinoma, and no standard approach has emerged...
April 17, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28405833/interpathologist-concordance-in-the-histological-diagnosis-of-focal-prostatic-atrophy-lesions-acute-and-chronic-prostatitis-pin-and-prostate-cancer
#10
Francesca Giunchi, Kristina Jordahl, Enrico Bollito, Maurizio Colecchia, Carlo Patriarca, Antonietta D'Errico, Francesco Vasuri, Deborah Malvi, Alessandro Fornari, Luca Reggiani Bonetti, Barbara Corti, Mauro Papotti, Paolo DeGiuli, Massimo Loda, Rodolfo Montironi, Michelangelo Fiorentino, Jennifer R Rider
Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer...
April 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28401338/serum-he4-is-correlated-to-prognostic-factors-and-survival-in-patients-with-endometrial-cancer
#11
A Stiekema, Car Lok, C M Korse, W J van Driel, V van der Noort, G G Kenter, K K Van de Vijver
The extent of surgery and the decision for adjuvant treatment in patients with endometrial cancer (EC) depend on the presence of risk factors for lymph node metastases and disease recurrence. Postoperative markers such as myometrial infiltration and specific mutations can select patients for adjuvant treatment but will not influence surgical planning. A biomarker stratifying patients into low-risk and high-risk groups before surgery could identify patients who benefit from more extensive surgery. Therefore, we evaluated the correlation of serum biomarker HE4 with clinical and recently identified prognostic pathological variables and survival...
April 11, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28391557/cutaneous-basal-cell-carcinoma-with-distant-metastasis-to-thorax-and-bone-a-clinicopathological-and-immunohistochemical-study-of-15-cases
#12
Annikka Weissferdt, Neda Kalhor, Cesar A Moran
Basal cell carcinoma (BCC) is the most common cutaneous malignancy and is characterized by a high cure rate after local excision. Metastatic BCC (mBCC) is an exceedingly rare event, associated with poor prognosis. We report clinicopathological and immunohistochemical features of 15 mBCC metastatic to the thorax and bone. The patients were 14 males and one female with a mean age at diagnosis of cutaneous BCC of 53 years and at metastasis of 64 years. Primary BCC were primarily located in the head and neck or torso and microscopically included five nodular, three basosquamous, three mixed, and one each of superficial, infiltrative, micronodular, and morpheaform types...
April 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28357490/annexin-a10-optimally-differentiates-between-intrahepatic-cholangiocarcinoma-and-hepatic-metastases-of-pancreatic-ductal-adenocarcinoma-a-comparative-study-of-immunohistochemical-markers-and-panels
#13
Julia Kälsch, Juliet Padden, Stefanie Bertram, Leona L Pott, Henning Reis, Daniela Westerwick, Christoph M Schaefer, Jan-P Sowa, Dorothe Möllmann, Christian Fingas, Alexander Dechȇne, Barbara Sitek, Martin Eisenacher, Ali Canbay, Maike Ahrens, Hideo A Baba
Discriminating intrahepatic cholangiocarcinoma (ICC) from hepatic metastases of pancreatic ductal adenocarcinoma (mPDAC) can be challenging. While pathologists might depend on clinical information regarding a primary tumor, their diagnosis will lead the patient either to potentially curative surgery (for ICC) or to palliation (for mPDAC). Beyond the validation of recently published potential biomarkers for PDAC (primary or metastatic) in a large cohort, we assessed diagnostic performance of the most promising candidates in the challenging task of discriminating metastatic PDAC (mPDAC) from ICC...
March 29, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28357489/molecular-genetic-and-immunotherapeutic-targets-in-metastatic-melanoma
#14
REVIEW
C Melis, A Rogiers, O Bechter, Joost J van den Oord
In recent years, melanoma treatment has radically changed with the emergence of targeted therapies and immunotherapies. Both have led to improved survival for patients with advanced or unresectable melanoma. Targeted therapies with BRAF inhibitors in the lead use the presence of activating driver mutations to inhibit tumour growth. Forty to 60% of melanomas harbour BRAF mutations, which makes them susceptible to treatment with BRAF and/or MEK inhibitors. In parallel, the development of immunotherapeutic agents has also expanded...
March 29, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28353089/histological-immunohistological-and-molecular-characteristics-of-intraductal-precursor-of-carcinoma-ex-pleomorphic-adenoma-support-a-multistep-carcinogenic-process
#15
Stephan Ihrler, Orlando Guntinas-Lichius, Abbas Agaimy, Agnes Wolf, Martin Mollenhauer
In recent years, multistep carcinogenesis of carcinoma ex pleomorphic adenoma (CEPA) has been identified, starting with intraductal neoplasia within pre-existent pleomorphic adenoma (PA). However, as yet there is no consensus regarding clinical relevance and appropriate terminology of precursor lesions in CEPA. We therefore decided to investigate precursor lesions, especially intraductal carcinoma, in a series of 85 cases of CEPA. Intraductal carcinoma confined by benign myoepithelial cells was found in 60 cases and mostly exhibited high-grade cellular atypia, increased cellular proliferation and frequent genetic alterations (TP53, Her2-neu, androgen receptor)...
March 28, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28349238/strong-association-of-insulin-like-growth-factor-1-receptor-expression-with-histologic-grade-subtype-and-hpv-status-in-penile-squamous-cell-carcinomas-a-tissue-microarray-study-of-112-cases
#16
Sheila F Faraj, Nilda Gonzalez-Roibon, Enrico Munari, Rajni Sharma, Arthur L Burnett, Antonio L Cubilla, George J Netto, Alcides Chaux
Insulin-like growth factor-1 receptor (IGF1R) plays a key role in cell growth and transformation. It is overexpressed in several solid tumors. This study evaluates IGF1R immunoexpression in penile squamous cell carcinoma (SCC). Four tissue microarrays were built from formalin-fixed, paraffin-embedded blocks of 112 penile SCC from Paraguay. Membranous IGF1R expression was evaluated by immunohistochemistry using two different approaches. An H-score was calculated in each spot (stain intensity by extent), and a median score per tumor was obtained...
March 27, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28349237/histopathologic-features-predict-survival-in-diffuse-pleural-malignant-mesothelioma-on-pleural-biopsies
#17
Cyril Habougit, Béatrice Trombert-Paviot, Georgia Karpathiou, François Casteillo, Sophie Bayle-Bleuez, Pierre Fournel, Jean-Michel Vergnon, Olivier Tiffet, Michel Péoc'h, Fabien Forest
Malignant pleural mesothelioma is a rare tumor with a poor prognosis. The only universally recognized pathological prognostic factor is histopathological subtype with a shorter survival in non-epithelioid subtypes. Recently, a grading of epithelioid mesothelioma on surgical resection has been proposed. The aim of our work is to assess the prognostic role of several histopathological factors on a retrospective cohort of 116 patients diagnosed as a pleural mesothelioma for more than 95% of patients on pleural biopsy...
March 27, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28343306/the-ins-and-outs-of-molecular-pathology-reporting
#18
REVIEW
Véronique Tack, Kelly Dufraing, Zandra C Deans, Han J van Krieken, Elisabeth M C Dequeker
The raid evolution in molecular pathology resulting in an increasing complexity requires careful reporting. The need for standardisation is clearer than ever. While synoptic reporting was first used for reporting hereditary genetic diseases, it is becoming more frequent in pathology, especially molecular pathology reports too. The narrative approach is no longer feasible with the growing amount of essential data present on the report, although narrative components are still necessary for interpretation in molecular pathology...
March 26, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28343305/clinicopathologic-and-genetic-features-of-primary-bronchopulmonary-mucoepidermoid-carcinoma-the-md-anderson-cancer-center-experience-and-comprehensive-review-of-the-literature
#19
Alireza Salem, Diana Bell, Boris Sepesi, Vassiliki Papadimitrakopoulou, Adel El-Naggar, Cesar A Moran, Neda Kalhor
Primary bronchopulmonary mucoepidermoid carcinoma (BPMEC) is a rare tumor. The fusion protein MECT1-MAML2 has been implicated as a causative genetic event in salivary and BPMECs. Several studies have shown the impact of MECT1-MAML2 on the diagnosis and prognosis of salivary gland mucoepidermoid carcinoma; however, few studies have been published regarding MECT1-MAML2 in the context of primary BPMEC. We describe the clinicopathologic, genetic, and outcome data of 16 patients with BPMEC. Clinicopathologic features were recorded from the electronic medical records...
March 25, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28326441/protuberant-fibro-osseous-lesion-of-the-skull-two-cases-with-occipital-lesions
#20
Naoko Sato, Takatoshi Aoki, Nobuhiko Mukai, Shinji Yotsumoto, Koji Irie, Masanori Hisaoka
No abstract text is available yet for this article.
March 22, 2017: Virchows Archiv: An International Journal of Pathology
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