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Virchows Archiv: An International Journal of Pathology

Huiying He, Kiril Trpkov, Petr Martinek, Ozlem Tanas Isikci, Cristina Maggi-Galuzzi, Reza Alaghehbandan, Anthony J Gill, Maria Tretiakova, Jose Ignacio Lopez, Sean R Williamson, Delia Perez Montiel, Maris Sperga, Eva Comperat, Fadi Brimo, Ali Yilmaz, Kristyna Pivovarcikova, Kveta Michalova, David Slouka, Kristyna Prochazkova, Milan Hora, Michael Bonert, Michal Michal, Ondrej Hes
The spectrum of the renal oncocytic tumors has been expanded in recent years to include several novel and emerging entities. We describe a cohort of novel, hitherto unrecognized and morphologically distinct high-grade oncocytic tumors (HOT), currently diagnosed as "unclassified" in the WHO classification. We identified 14 HOT by searching multiple institutional archives. Morphologic, immunohistochemical (IHC), molecular genetic, and molecular karyotyping studies were performed to investigate these tumors...
September 19, 2018: Virchows Archiv: An International Journal of Pathology
Dina Tiniakos, Diana Jurk
No abstract text is available yet for this article.
September 17, 2018: Virchows Archiv: An International Journal of Pathology
Michele Simbolo, Caterina Vicentini, Andrea Mafficini, Matteo Fassan, Serena Pedron, Vincenzo Corbo, Luca Mastracci, Borislav Rusev, Corrado Pedrazzani, Luca Landoni, Federica Grillo, Sara Cingarlini, Guido Rindi, Claudio Luchini, Aldo Scarpa, Rita T Lawlor
Small intestine neuroendocrine tumors (SI-NETs) represent the most common histotype among small intestine neoplasms, and metastatic disease is usually present at diagnosis. A retrospective series of 52 sporadic primary surgically resected SI-NETs, which were metastatic at diagnosis, was analyzed by high-coverage target sequencing (HCTS) for the mutational status of 57 genes and copy number status of 40 genes selected from recently published genome sequencing data. Seven genes were found to be recurrently mutated: CDKN1B (9...
September 16, 2018: Virchows Archiv: An International Journal of Pathology
Larisa Zavalishina, Ilya Tsimafeyeu, Patrisia Povilaitite, Grigory Raskin, Yulia Andreeva, Alexey Petrov, Ekaterina Kharitonova, Alexey Rumyantsev, Inna Pugach, Georgy Frank, Sergei Tjulandin
In this collaborative study by the Russian Society of Clinical Oncology and the Russian Society of Pathology, we assessed the concordance among three validated, commercially available PD-L1 immunohistochemistry assays for patients with urothelial cancer. Tumors from 100 urothelial cancer patients were stained with the antibody clones 22C3 (Agilent), SP142 (Ventana Medical Systems), and SP263 (Ventana Medical Systems), which are used in clinical trials of second-line therapy with checkpoint inhibitors. Four trained pathologists independently evaluated the percentages of tumor cells (TC) and tumor-infiltrating immune cells (IC) that were stained at any intensity by each of the antibodies...
September 13, 2018: Virchows Archiv: An International Journal of Pathology
Magda Zanelli, Maria Cecilia Mengoli, Riccardo Valli, Elisabetta Froio, Alessandra Bisagni, Maurizio Zizzo, Loredana De Marco, Stefano Ascani
Primary classic Hodgkin lymphoma of the gastrointestinal tract represents a rare occurrence. A full patient's work-up is essential in order to exclude a secondary intestinal involvement. Histologically Epstein-Barr virus mucocutaneous ulcer closely resembles Hodgkin lymphoma. The differential diagnosis between these two entities is relevant, since both the therapeutic approach and the clinical behavior are different. Herein, we describe a case of primary classic Hodgkin lymphoma arising in the ileum and a case of Epstein-Barr virus mucocutaneous ulcer of the colon, focusing on the main clinicopathological differences...
September 7, 2018: Virchows Archiv: An International Journal of Pathology
Jaya Ruth Asirvatham, Julie M Jorns, Lili Zhao, Deborah O Jeffries, Angela J Wu
A diagnosis of papilloma with atypia on core biopsy (CB) requires excision, as the risk of associated malignancy is high (average 36.9%). The management of benign intraductal papillomas (IP) diagnosed on CB is controversial due to varying upgradation rates (0-29%, average 7%) reported on excision. Our aim was to study the clinical, radiological, and pathological features associated with benign IP upgradation at our institution. An electronic data base search (keyword papilloma), from Jan. 2000-Aug. 2015 identified 258 CBs...
September 6, 2018: Virchows Archiv: An International Journal of Pathology
Shatavisha Dasgupta, Patricia C Ewing-Graham, Folkert J van Kemenade, Helena C van Doorn, Vincent Noordhoek Hegt, Senada Koljenović
Differentiated vulvar intraepithelial neoplasia (dVIN) is the precursor lesion of HPV-negative vulvar squamous cell carcinoma (VSCC). The histopathological diagnosis of dVIN can be challenging, as it often resembles vulvar non-neoplastic epithelial disorders (NNED), especially lichen sclerosus (LS). We aimed to establish the most specific and reproducible histological features of dVIN and assessed cytokeratin 13 (CK13) and cytokeratin 17 (CK17) immunohistochemistry as a diagnostic aid. Consecutive cases of dVIN (n = 180) and LS (n = 105) from the period 2010 to 2013 were reviewed using a checklist of histological features...
September 6, 2018: Virchows Archiv: An International Journal of Pathology
Matthias Tallegas, Sylvie Fraitag, Aurélien Binet, Daniel Orbach, Anne Jourdain, Stéphanie Reynaud, Gaëlle Pierron, Marie-Christine Machet, Annabel Maruani
Cutaneous spindle-cell neoplasms in adults as well as children represent a frequent dilemma for pathologists. Along this neoplasm spectrum, the differential diagnosis with CD34-positive proliferations can be challenging, particularly concerning neoplasms of fibrohistiocytic and fibroblastic lineages. In children, cutaneous and superficial soft-tissue neoplasms with CD34-positive spindle cells are associated with benign to intermediate malignancy potential and include lipofibromatosis, plaque-like CD34-positive dermal fibroma, fibroblastic connective tissue nevus, and congenital dermatofibrosarcoma protuberans...
September 6, 2018: Virchows Archiv: An International Journal of Pathology
Spasenija Savic Prince, Lukas Bubendorf
Checkpoint inhibitors targeting the PD-1/PD-L1 axis are a promising treatment option in several tumor types. PD-L1 expression detected by immunohistochemistry is the first clinically validated predictive biomarker for response to PD-1/PD-L1 inhibitors, though its predictive value varies significantly between tumor types. With the approval of pembrolizumab monotherapy for treatment-naïve, advanced non-small cell lung cancer, PD-L1 testing has to become broadly available in pathology laboratories. When PD-L1 testing started to be introduced in routine pathology practice, there were several open issues, which needed to be addressed in order to provide accurate results...
September 1, 2018: Virchows Archiv: An International Journal of Pathology
Isabela Werneck da Cunha, Walter Henriques da Costa, Mariana A Morini, Stephania Martins Bezerra, Dirce Maria Carraro, Giovana Tardin Torrezan, Maria Nirvana Cruz Formiga, Gustavo Cardoso Guimaraes, Stenio Cassio Zequi, Fernando Augusto Soares
Renal cell carcinoma (RCC) accounts for 2-3% of all malignant disease in adults. Hereditary RCC represents 5 to 8% of kidney tumors. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) represents an autosomal dominant syndrome that results from a germline mutation in fumarate hydratase gene (FH). HLRCC patients typically present with skin or uterine leiomyomas and renal neoplasms. HLRCC was recently recognized as a distinct renal tumor subtype by the WHO 2016 classification. Many morphological patterns such as papillary, solid, tubular, and cystic had been described as part of morphological aspects of HLRCC...
August 31, 2018: Virchows Archiv: An International Journal of Pathology
Judith V M G Bovée
No abstract text is available yet for this article.
August 29, 2018: Virchows Archiv: An International Journal of Pathology
Giuseppe Lo Bello, Ayse U Akarca, Maria Raffaella Ambrosio, Claudio Agostinelli, Hernan Molina-Kirsch, Alan Ramsay, Manuel Rodriguez-Justo, Matt Pugh, Shuchun Zhao, Monique DeLisser, Elena Sabattini, Stefan Dojcinov, Stefano A Pileri, Yasodha Natkunam, Lorenzo Leoncini, Teresa Marafioti
Granulysin is a cytolytic protein expressed in cytotoxic T and natural killer (NK) cells. Abnormal serum levels of granulysin in lymphomas with NK and cytotoxic phenotype have been shown to correlate with tumour progression. In this study, we investigated the expression pattern of granulysin in routine sections of normal and reactive lymphoid tissues as well as in a large series of lymphomas. In normal tissues, granulysin labelled a small population of cells that double immunostaining revealed to belong to the pool of cytotoxic T/NK cells...
August 27, 2018: Virchows Archiv: An International Journal of Pathology
Ben Davidson
The ability to detect cancer cells in the blood or in the bone marrow offers invaluable information which potentially impacts early diagnosis, monitoring of treatment, and prognosis. Accessing blood or other body fluids has the additional advantage of being less invasive than biopsy. Consequently, considerable effort has been invested in the last 20 years in optimizing assays which may identify malignant cells at these anatomic sites. Detection of nucleic acids has been applied as alternative approach in this context, first targeting single cancer-associated genes using PCR-based technology, and recently using assays which identify different DNA classes, as well as microRNAs and exosomes...
August 25, 2018: Virchows Archiv: An International Journal of Pathology
Heinz Läubli, Stefan Dirnhofer, Alfred Zippelius
Recent progress in the understanding of immune responses to cancer and how tumor cells evade immune control have led to the successful introduction of cancer immunotherapy, in particular immune checkpoint inhibitors (ICI). Treatment of cancer patients with immunotherapy such as ICIs has led to new challenges, including starting and stopping rules for immunotherapy, the management of immune-related adverse events, and logistic issues for the production of cellular therapies and viral delivery vectors. These challenges are not disease- or organ-specific and several potential biomarkers to predict response to ICI are under investigation...
August 25, 2018: Virchows Archiv: An International Journal of Pathology
Cristina Díaz Del Arco, Lourdes Estrada Muñoz, Elena Molina Roldán, Mª Ángeles Cerón Nieto, Luis Ortega Medina, Soledad García Gómez de Las Heras, Mª Jesús Fernández Aceñero
Several classification systems have been described for stratifying patients with gastric carcinoma (GC). However, their prognostic value is low, and there is an urgent need for identification of molecular markers and development of new classifications. Retrospective study of 206 cases of GC diagnosed and surgically resected in our hospital between 2000 and 2017. Clinicopathological features of all cases were assessed and tissue microarrays were constructed for immunohistochemical (IHC) study. Patients were stratified based on IHC results...
August 23, 2018: Virchows Archiv: An International Journal of Pathology
Mac Versluis, A Plat, M de Bruyn, X Matias-Guiu, J Trovic, C Krakstad, H W Nijman, T Bosse, G H de Bock, H Hollema
Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial-mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAM is an adhesion molecule that has been involved in EMT as a marker for mesenchymal phenotype. We examined expression of L1CAM in UCS in a cohort of 90 cases from four different centers. Slides were immunohistochemically stained for L1CAM and scored in four categories (0%, < 10%, 10-50%, and > 50%)...
August 23, 2018: Virchows Archiv: An International Journal of Pathology
Julius-Valentin Baumgart, Christiane Stuhlmann-Laeisz, Ute Hegenbart, Johanna Nattenmüller, Stefan Schönland, Sandra Krüger, Hans-Michael Behrens, Christoph Röcken
Immunoglobulin-derived light-chain (AL) amyloidosis of lungs and bronchi can appear as a systemic and a local form. While systemic AL amyloidosis may need haemato-oncological care, the localised form can be treated restrained. We re-evaluated 207 specimens of lungs and bronchi sent in for amyloid diagnostics. Amyloid was diagnosed by polarization microscopy using Congo red-stained tissue specimens and classified immunohistochemically. Histoanatomical amyloid distribution patterns were documented as well as additional histological findings...
August 22, 2018: Virchows Archiv: An International Journal of Pathology
Thomas Menter, Alexandar Tzankov
Chromosome 9 harbors several relevant oncogenes related to hematolymphoid malignancies and one specific region, 9p24, has come into the focus of attention in the last years as it contains recurrently mutant genes of therapeutic interest. The most prominent genes of this locus are programmed death ligands 1 and 2 (PDL1/PDL2), with the amplification of PDL1 being a hallmark of both classical Hodgkin and primary mediastinal B cell lymphoma, and Janus kinase 2 (JAK2), which is point-mutated in myeloproliferative neoplasms and other myeloid malignancies, and rearranged in PCM1-JAK2-positive myeloid/lymphoid neoplasms with eosinophila...
August 21, 2018: Virchows Archiv: An International Journal of Pathology
Rita T Lawlor, Valentina Daprà, Ilaria Girolami, Antonio Pea, Camilla Pilati, Alessia Nottegar, Paola Piccoli, Claudia Parolini, Nicola Sperandio, Paola Capelli, Aldo Scarpa, Claudio Luchini
CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests...
August 21, 2018: Virchows Archiv: An International Journal of Pathology
Kazuki Kanayama, Hiroshi Imai, Eri Usugi, Taizo Shiraishi, Yoshifumi S Hirokawa, Masatoshi Watanabe
Overexpression of human epidermal growth factor receptor 2 (HER2) protein in association with HER2 gene amplification is found in 7-34% of gastric cancers. In breast cancer, HER2 overexpression is a prognostic factor in advanced cases and is associated with tumor progression in ductal carcinoma in situ. However, the biological and clinical significance of HER2 status in early gastric cancer is unknown. Here, we aimed to examine the correlation between HER2 gene amplification and tumor progression in early gastric cancer...
August 17, 2018: Virchows Archiv: An International Journal of Pathology
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