journal
https://read.qxmd.com/read/38528286/exploring-epigenetic-and-genetic-modulation-in-animal-responses-to-thermal-stress
#1
REVIEW
Wang Jianfang, Sayed Haidar Abbas Raza, Sameer D Pant, Zhao Juan, Ajit Prakash, Sameh A Abdelnour, Bandar Hamad Aloufi, Zeinab M H Mahasneh, Ahmed A Amin, Borhan Shokrollahi, Linsen Zan
There is increasing evidence indicating that global temperatures are rising significantly, a phenomenon commonly referred to as 'global warming', which in turn is believed to be causing drastic changes to the global climate. Global warming (GW) directly impacts animal health, reproduction, production, and welfare, presenting several challenges to livestock enterprises. Thermal stress (TS) is one of the key consequences of GW, and all animal species, including livestock, have diverse physiological, epigenetic and genetic mechanisms to respond to TS...
March 25, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38526683/hypoxia-challenged-pancreatic-adenocarcinoma-cell-derived-exosomal-circr3hcc1l-drives-tumor-growth-via-upregulating-pkm2-through-sequestering-mir-873-5p
#2
JOURNAL ARTICLE
Luoluo Wang, Shuping Zhou, Yi Ruan, Xiang Wu, Xueming Zhang, Yi Li, Dongjian Ying, Yeting Lu, Yuan Tian, Gong Cheng, Jing Zhang, Kaiji Lv, Xinhua Zhou
Pancreatic adenocarcinoma (PAAD) is a fatal disease with poor survival. Increasing evidence show that hypoxia-induced exosomes are associated with cancer progression. Here, we aimed to investigate the function of hsa_circ_0007678 (circR3HCC1L) and hypoxic PAAD cell-derived exosomal circR3HCC1L in PAAD progression. Through the exoRBase 2.0 database, we screened for a circular RNA circR3HCC1L related to PAAD. Changes of circR3HCC1L in PAAD samples and cells were analyzed with real-time quantitative polymerase chain reaction (RT-qPCR)...
March 25, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38520499/identification-of-potential-hub-genes-related-to-acute-pancreatitis-and-chronic-pancreatitis-via-integrated-bioinformatics-analysis-and-in-vitro-analysis
#3
JOURNAL ARTICLE
Lu Yuan, Yiyuan Liu, Lingyan Fan, Cai Sun, Sha Ran, Kuilong Huang, Yan Shen
Acute pancreatitis (AP) and chronic pancreatitis (CP) are considered to be two separate pancreatic diseases in most studies, but some clinical retrospective analyses in recent years have found some degree of correlation between the two in actual treatment, however, the exact association is not clear. In this study, bioinformatics analysis was utilized to examine microarray sequencing data in mice, with the aim of elucidating the critical signaling pathways and genes involved in the progression from AP to CP...
March 23, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38514598/revealing-a-novel-methylated-integrin-alpha-8-related-to-extracellular-matrix-and-anoikis-resistance-using-proteomic-analysis-in-the-immune-microenvironment-of-lung-adenocarcinoma
#4
JOURNAL ARTICLE
Tingting Liu, Wen Ji, Xue Cheng, Lin Lv, Xiaohui Yu, Na Wang, Mengcong Li, Tinghua Hu, Zhihong Shi
Genomic epigenetics of extracellular matrix (ECM) play an important role in lung adenocarcinoma (LUAD). Our study identified a signature of potential prognostic genes associated with ECM and constructed immune risk-related prognosis model in LUAD. We downloaded mRNAs transcriptome data, miRNAs expression data, and clinical patient information for LUAD based on The Cancer Genome Atlas. "Limma, clusterProfiler, ggplot2" R packages and GSEA were used to analyze meaningful genes and explore potential biological function...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38512428/quantitative-proteomic-analysis-identifying-and-evaluating-traf6-and-il-8-as-potential-diagnostic-biomarkers-in-neonatal-patients-with-necrotizing-enterocolitis
#5
JOURNAL ARTICLE
Jing Wang, Minhan Qu, Aijuan Qiu, Lili Yang, Hui Xu, Shenglin Yu, Zhaojun Pan
Necrotizing enterocolitis (NEC) is a common gastrointestinal complication in premature infants, resulting in high morbidity and mortality, and its early detection is crucial for accurate treatment and outcome prediction. Extensive research has demonstrated a clear correlation between NEC and extremely low birth weight, degree of preterm, formula feeding, infection, hypoxic/ischemic damage, and intestinal dysbiosis. The development of noninvasive biomarkers of NEC from stool, urine, and serum has attracted a great deal of interest because to these clinical connections and the quest for a deeper knowledge of disease pathophysiology...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38512427/polylactic-co-glycolic-acid-polymer-based-nano-encapsulation-using-recombinant-maltoporin-of-aeromonas-hydrophila-as-potential-vaccine-candidate
#6
JOURNAL ARTICLE
Mave Harshitha, Ruveena D'souza, Somanath Disha, Uchangi Satyaprasad Akshath, Saurabh Dubey, Hetron Mweemba Munang'andu, Anirban Chakraborty, Indrani Karunasagar, Biswajit Maiti
Aquaculture production has been incurring economic losses due to infectious diseases by opportunistic pathogens like Aeromonas hydrophila, a bacterial agent that commonly affects warm water aquacultured fish. Developing an effective vaccine with an appropriate delivery system can elicit an immune response that would be a useful disease management strategy through prevention. The most practical method of administration would be the oral delivery of vaccine developed through nano-biotechnology. In this study, the gene encoding an outer membrane protein, maltoporin, of A...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38512426/the-impact-of-microrna-snps-on-breast-cancer-potential-biomarkers-for-disease-detection
#7
REVIEW
Sakshi Chauhan, Runjhun Mathur, Abhimanyu Kumar Jha
Breast cancer is considered a significant health concern worldwide, with genetic predisposition playing a critical role in its etiology. Single nucleotide polymorphisms (SNPs), particularly those within the 3' untranslated regions (3'UTRs) of target genes, are emerging as key factors in breast cancer susceptibility. Specifically, miRNAs have been recognized as possible novel approach for biomarkers discovery for both prognosis and diagnosis due to their direct association with cancer progression. Regional disparities in breast cancer incidence underscore the need for precise interventions, considering socio-cultural and economic factors...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38509332/in-silico-identification-characterization-and-expression-analysis-of-genes-involved-in-resistant-starch-biosynthesis-in-potato-solanum-tuberosum-l-varieties
#8
JOURNAL ARTICLE
Jaspreet Kaur, Pooja Manchanda, Harleen Kaur, Pankaj Kumar, Anu Kalia, Sat Pal Sharma, Monica Sachdeva Taggar
Potato (Solanum tuberosum L.), an important horticultural crop is a member of the family Solanaceae and is mainly grown for consumption at global level. Starch, the principal component of tubers, is one of the significant elements for food and non-food-based applications. The genes associated with biosynthesis of starch have been investigated extensively over the last few decades. However, a complete regulation pathway of constituent of amylose and amylopectin are still not deeply explored. The current in-silico study of genes related to amylose and amylopectin synthesis and their genomic organization in potato is still lacking...
March 20, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38507018/phytochemistry-of-medicinal-herbs-belongs-to-asclepiadaceae-family-for-therapeutic-applications-a-critical-review
#9
REVIEW
Navytchmathra Gammatantrawet, Chuyên Thuận Nguyễn, Chanthana Susawaengsup, Aizi Nor Mazila Ramli, Krittiya Tongkoom, Tawan Chatsungnoen, Rapeephun Dangtungee, Prakash Bhuyar
The world of pharmaceutical research has been increasingly turning its gaze toward the treasure trove of natural products in search of novel drugs and therapeutic agents. Amidst the vast array of medicinal plants that dot our planet, the Asclepiadaceae family unexplored species have piqued the interest of researchers. Both medicinal plants are indigenous to specific regions and have been integral to traditional medicine systems for centuries. This systematic review aims to provide a comprehensive summary of the current knowledge regarding the phytochemical profile of these plants and their potential implications in the pharmaceutical industry...
March 20, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38502429/anti-proliferative-pro-apoptotic-and-chemosensitizing-potential-of-3-acetyl-11-keto-%C3%AE-boswellic-acid-akba-against-prostate-cancer-cells
#10
JOURNAL ARTICLE
Mahima Verma, Shireen Fatima, Mohd Saeed, Irfan Ahmad Ansari
Prostate cancer incidences are rising worldwide at an alarming rate. Drug resistance and relapse are two major challenges in the treatment of prostate cancer. Therefore, new multimodal, safe, and effective therapeutic agents are urgently required which could effectively mitigate the menace of tumor recurrence and chemo-resistance. Plant-derived products are increasingly being utilized due to their antioxidant, antibacterial, and anti-tumor potential. In the current study, 3-acetyl-11-keto-β-boswellic acid, a triterpenoid isolated from plant Boswellia, was utilized to ascertain its chemotherapeutic potential against human prostate cancer cells...
March 19, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38498284/importance-of-inter-residue-contacts-for-understanding-protein-folding-and-unfolding-rates-remote-homology-and-drug-design
#11
REVIEW
Balasubramanian Harihar, Konda Mani Saravanan, Michael M Gromiha, Samuel Selvaraj
Inter-residue interactions in protein structures provide valuable insights into protein folding and stability. Understanding these interactions can be helpful in many crucial applications, including rational design of therapeutic small molecules and biologics, locating functional protein sites, and predicting protein-protein and protein-ligand interactions. The process of developing machine learning models incorporating inter-residue interactions has been improved recently. This review highlights the theoretical models incorporating inter-residue interactions in predicting folding and unfolding rates of proteins...
March 18, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38498283/understanding-propofol-s-protective-mechanism-in-tubular-epithelial-cells-mitigating-pyroptosis-via-the-mir-143-3p-atpase-na%C3%A2-%C3%A2-k%C3%A2-%C3%A2-transporting-subunit-alpha-2-pathway-in-renal-ischemia-reperfusion
#12
JOURNAL ARTICLE
Hongjun Kan, Miaomiao Zhao, Wei Wang, Baozhong Sun
Propofol (Pro), a prevalent intravenous anesthetic, has recently been recognized for its potential in mitigating ischemia-reperfusion (I/R) injuries. Despite a plethora of evidence suggesting the beneficial effects of low-dose Pro in renal I/R injury (RI/R), its role in modulating pyroptosis in renal tubular epithelial cells consequent to RI/R has not been thoroughly elucidated. In our investigation, we explored the therapeutic potential of Pro against pyroptosis in renal tubular epithelial cells under the duress of RI/R, employing both in vivo and in vitro models, while deciphering the intricate molecular pathways involved...
March 18, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38492118/yy1-contributes-to-the-inflammatory-responses-of-mycobacterium-tuberculosis-infected-macrophages-through-transcription-activation-mediated-upregulation-tlr4
#13
JOURNAL ARTICLE
Xing Yang, Yu Chen, Bingshuang Pu, Xuan Yuan, Jiaojiao Wang, Chun Chen
Tuberculosis (TB) is a chronic respiratory infectious disease and is induced by Mycobacterium tuberculosis (M.tb) infection. Macrophages serve as the cellular home in immunoreaction against M.tb infection, which is tightly regulated through Toll-like receptor 4 (TLR4) expression. Therefore, this study is designed to explore the role and mechanism of TLR4 in mycobacterial injury in human macrophages (THP-1 cells) after M.tb infection. Cell proliferation and apoptosis were assessed using MTT, EdU, and flow cytometry assays...
March 16, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38491245/plant-produced-therapeutic-crizanlizumab-monoclonal-antibody-binds-p-selectin-to-alleviate-vaso-occlusive-pain-crises-in-sickle-cell-disease
#14
REVIEW
Taewon Yang, Hyunjoo Hwang, Kibum Kim, Yerin Kim, Richard D Cummings, Yong Kyoo Shin, Taejin Lee, Kisung Ko
Sickle Cell Disease (SCD) is a severe genetic disorder causing vascular occlusion and pain by upregulating the adhesion molecule P-selectin on endothelial cells and platelets. It primarily affects infants and children, causing chronic pain, circulatory problems, organ damage, and complications. Thus, effective treatment and management are crucial to reduce SCD-related risks. Anti-P-selectin antibody Crizanlizumab (Crimab) has been used to treat SCD. In this study, the heavy and light chain (HC and LC) genes of anti-P-Selectin antibody Crimab were cloned into a plant expression binary vector...
March 15, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38489015/computational-analysis-of-non-synonymous-snps-in-atm-kinase-structural-insights-functional-implications-and-inhibitor-discovery
#15
JOURNAL ARTICLE
Nagesh Kishan Panchal, Poorva Samdani, Tiasa Sengupta, Sabina Evan Prince
Ataxia telangiectasia-mutated (ATM) protein kinase, a key player in cellular integrity regulation, is known for its role in DNA damage response. This study investigates the broader impact of ATM on cellular processes and potential clinical manifestations arising from mutations, aiming to expand our understanding of ATM's diverse functions beyond conventional roles. The research employs a comprehensive set of computational techniques for a thorough analysis of ATM mutations. The mutation data are curated from dbSNP and HuVarBase databases...
March 15, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38478260/hells-knockdown-inhibits-the-malignant-progression-of-lung-adenocarcinoma-via-blocking-akt-creb-pathway-by-downregulating-kif11
#16
JOURNAL ARTICLE
Gang Yang, Jinsong Fu, Jiawei Wang, Mei Ding
Lung adenocarcinoma (LUAD) is a malignant tumor with the characteristics of progressive advancement and high mortality rate worldwide. We aimed to explore the role and mechanism of helicase Lymphoid-Specific (HELLS) in LUAD. Bioinformatics databases were applied to predict HELLS and kinesin family member (KIF)11 expression in LUAD tissues. The expressions of HELLS and KIF11 before and after HELLS knockdown were detected by RT-qPCR and western blot. After HELLS was knocked down, the proliferative, migratory, and invasive capabilities of A549 cells were evaluated...
March 13, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38472694/identification-of-key-lncrnas-in-gout-under-copper-death-and-iron-death-mechanisms-a-study-based-on-cerna-network-analysis-and-random-forest-algorithm
#17
JOURNAL ARTICLE
Zi-Chen Shao, Wei-Kang Sun, Qin-Qin Deng, Ling Cheng, Xin Huang, Lie-Kui Hu, Hua-Nan Li
This study focused on identifying potential key lncRNAs associated with gout under the mechanisms of copper death and iron death through ceRNA network analysis and Random Forest (RF) algorithm, which aimed to provide new insights into the molecular mechanisms of gout, and potential molecular targets for future therapeutic strategies of gout. Initially, we conducted an in-depth bioinformatics analysis of gout microarray chips to screen the key cuproptosis-related genes (CRGs) and key ferroptosis-related genes (FRGs)...
March 12, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38470557/sufentanil-suppresses-cell-carcinogenesis-via-targeting-mir-186-5p-hmgb1-axis-and-wnt-%C3%AE-catenin-pathway-in-non-small-cell-lung-cancer
#18
JOURNAL ARTICLE
Di Liu, Ye Huang, You Shang
Sufentanil is a common opioid anesthetic agent, which exerts anti-cancer properties in several cancer types. However, its action mechanisms in non-small cell lung cancer (NSCLC) are unclear. Therefore, the present study investigated the pharmacological effect of sufentanil on miRNAs in NSCLC treatment. In this study, after treatment with sufentanil, the proliferation, migration, invasion and apoptosis of A549 and H1299 NSCLC cell lines were measured by cell counting kit-8 (CCK-8) assay, colony formation assay, transwell assays and flow cytometry...
March 12, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38466505/platelet-derived-microvesicles-mediate-cardiomyocyte-ferroptosis-by-transferring-acsl1-during-acute-myocardial-infarction
#19
JOURNAL ARTICLE
Yunfeng Zhao, Rui Cui, Ran Du, Chunmei Song, Fei Xie, Lin Ren, Junquan Li
Acute myocardial infarction (AMI) is one of the critical health conditions often caused by the rupture of unstable coronary artery plaque, triggering a series of events, such as platelet activation, thrombus formation, coronary artery blockage, lasted severe ischemia, and hypoxia in cardiomyocytes, and culminating in cell death. Platelet-derived microvesicles (PMVs) act as intermediates for cellular communication. Nevertheless, the role of PMVs in myocardial infarction remains unclear. Initially, AMI-related messenger ribose nucleic acid (mRNA) and micro RNA (miRNA) datasets from the Gene Expression Omnibus (GEO) database were analyzed, specifically focusing on the expressed genes associated with Ferroptosis...
March 11, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38461181/abridgement-of-microbial-esterases-and-their-eminent-industrial-endeavors
#20
REVIEW
Fatima Akram, Taseer Fatima, Ifrah Shabbir, Ikram Ul Haq, Ramesha Ibrar, Hamid Mukhtar
Esterases are hydrolases that contribute to the hydrolysis of ester bonds into both water-soluble acyl esters and emulsified glycerol-esters containing short-chain acyl groups. They have garnered significant attention from biotechnologists and organic chemists due to their immense commercial value. Esterases, with their diverse and significant properties, have become highly sought after for various industrial applications. Synthesized ubiquitously by a wide range of living organisms, including animals, plants, and microorganisms, these enzymes have found microbial esterases to be the preferred choice in industrial settings...
March 9, 2024: Molecular Biotechnology
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