journal
MENU ▼
Read by QxMD icon Read
search

International Journal of Clinical Pharmacology and Therapeutics

journal
https://www.readbyqxmd.com/read/29792395/how-are-patients-with-heart-failure-treated-in-primary-care
#1
Hélène Vaillant-Roussel, Bruno Pereira, Sylvaine Gibot-Boeuf, Romain Eschalier, Claude Dubray, Rémy Boussageon, Philippe Vorilhon
OBJECTIVE: The aim of this study was to assess the adherence of general practitioners (GPs) to guidelines in patients with heart failure with reduced ejection fraction (HFrEF) and to describe GPs' prescribing behavior regarding patients with heart failure with preserved ejection fraction (HFpEF). MATERIALS AND METHODS: Cross-sectional study as part of the ETIC trial. Five classes of drugs were described: angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs); β-blockers (BBs); mineralocorticoid receptor antagonists (MRAs); diuretics (thiazide or loop diuretics); and digoxin...
May 24, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29792394/concomitant-administration-of-candesartan-cilexetil-in-patients-on-paclitaxel-and-carboplatin-combination-therapy-increases-risk-of-severe-neutropenia
#2
Yurie Katsube, Daiki Hira, Masayuki Tsujimoto, Hiroyoshi Koide, Tetsuya Minegaki, Yoshito Ikeda, Shin-Ya Morita, Kohshi Nishiguchi, Tomohiro Terada
OBJECTIVE: Angiotensin receptor blockers (ARBs) are often used in patients on paclitaxel (PTX) and carboplatin combination (TC) therapy to treat hypertension caused by the co-administration of bevacizumab. The aim of this retrospective study was to analyze the association between co-administration of ARBs and the development of severe neutropenia in patients on TC therapy. MATERIALS AND METHODS: In this study, 211 concomitant medications were prescribed to 173 patients on TC therapy...
May 24, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29750634/effectiveness-of-febuxostat-in-patients-with-allopurinol-refractory-hyperuricemic-chronic-kidney-disease
#3
Chae Hee Kwak, Minji Sohn, Nayoung Han, Yoon-Sook Cho, Yon Su Kim, Jung Mi Oh
OBJECTIVE: As uncontrolled hyperuricemia has been associated with an increased risk of cardiovascular disease and the progression of chronic kidney disease (CKD), management of serum uric acid levels is important. The aim of this study was to evaluate the effectiveness of febuxostat in regulating uncontrolled hyperuricemia in patients with renal dysfunction. MATERIALS AND METHODS: We included patients with CKD and persistent uncontrolled hyperuricemia despite treatment with allopurinol...
May 11, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29701171/risk-factors-for-rhabdomyolysis-with-hmg-coa-reductase-inhibitors-identified-using-a-postmarketing-surveillance-database-in-japan
#4
Masayuki Hashiguchi, Jun Hakamata, Mikiko Shimizu, Junya Maruyama, Tsuyoshi Shiga, Mayumi Mochizuki
OBJECTIVE: To investigate quantitatively the risk factors for rhabdomyolysis or related symptoms associated with HMG-CoA reductase inhibitors (statins), we used the lipid-lowering drug database (32,157 patients) developed by the RAD-AR Council, Japan, based on the postmarketing surveillance (PMS) data of pharmaceutical companies to perform a nested case-control study. MATERIALS AND METHODS: Of 26,849 patients taking statins, the case group was composed of 51 patients who experienced rhabdomyolysis or related symptoms while taking statins, and the control group was 1,020 patients randomly selected from patients who did not experience rhabdomyolysis or related symptoms while taking statins...
April 27, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29701170/diagnosing-and-treating-dementia-in-german-primary-and-specialized-care-between-2011-and-2015
#5
Bernhard Michalowsky, Karel Kostev, Steve Iliffe, Wolfgang Hoffmann, Jens Bohlken
BACKGROUND: Whilst there was no upturn in detection rate of persons with dementia (PwD) in German general practitioner (GP) practices before 2012, dementia diagnoses markedly increased in 2013 and 2014. OBJECTIVE: (1) Verify the increase of dementia diagnoses in GP practices and neurologist/psychiatrist (NP) practices; (2) examine the subsequent prescription of antidementia drugs. MATERIALS AND METHODS: We performed a retrospective, longitudinal analysis of 874 GP and 141 NP practices collecting clinical data about 220,213 patients who received a dementia diagnosis (ICD-10: G30, F01, F03) between 2011 and 2015...
April 27, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29648533/the-effect-of-fluconazole-on-the-pharmacokinetics-of-everolimus-and-tacrolimus-in-a-heart-transplant-recipient-a-case-report
#6
Kazuki Nakagita, Kyoichi Wada, Yuka Terada, Sachi Matsuda, Nobue Terakawa, Akira Oita, Mitsutaka Takada
OBJECTIVE: Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has been used in combination with calcineurin inhibitors (tacrolimus and cyclosporine) to prevent allograft rejection following organ transplantation. In heart transplant recipients, everolimus should be maintained at a target blood concentration of 3 - 8 ng/mL, in combination with reduced-dose calcineurin inhibitors and therefore, requires strict monitoring. Fluconazole, an azole antifungal agent, affects blood concentration of tacrolimus by inhibiting the cytochromes P450 (CYP) 3A4 and 3A5...
April 12, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29648532/bioequivalence-of-a-fixed-dose-repaglinide-metformin-combination-tablet-and-equivalent-doses-of-repaglinide-and-metformin-tablets
#7
Hea-Young Cho, Lien Ngo, Sang-Ki Kim, Yoonho Choi, Yong-Bok Lee
OBJECTIVE: This study was conducted to determine whether a fixed-dose combination (FDC) tablet of repaglinide/metformin (2/500 mg) is equivalent to coadministration of equivalent doses of individual (EDI) tablets of repaglinide (2 mg) and metformin (500 mg) in healthy Korean male subjects. MATERIALS AND METHODS: This study was conducted as an open-label, randomized, single-dose, two-period, two-sequence crossover design in 50 healthy Korean male subjects who received an FDC tablet or EDI tablets...
April 12, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29648531/propafenone-quantification-in-human-plasma-by-high-performance-liquid-chromatography-coupled-with-electrospray-tandem-mass-spectrometry-in-a-bioequivalence-study
#8
Beatrice Severino, Giancarlo Luisi, Renan Donomae Iwamoto, Ronilson Agnaldo Moreno, Victor Perez Teixeira, Paola Di Vaio, Irene Saccone, Elisa Magli, Vincenzo Santagada, Giuseppe Caliendo, Gustavo D Mendes, Gilberto De Nucci
Propafenone is an antiarrhythmic drug applied to ventricular arrhythmias, initially recognized as a sodium channel blocker. This study aims to evaluate the bioequivalence of two propafenone formulations (300 mg tablet) in healthy subjects under non-fasting conditions. The study was conducted as an open, randomized, 2-period design with a 2-sequence (RT, TR) with a 1-week washout interval. The subjects were selected for the study after having their health status previously assessed by a clinical evaluation and laboratory tests (biochemical and hematological parameters, and urinalysis)...
April 12, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29633699/pharmacokinetics-of-immediate-release-extended-release-and-gastric-retentive-gabapentin-formulations-in-healthy-adults
#9
Dennis Swearingen, Gerald M Aronoff, Sabrina Ciric, Ritu Lal
OBJECTIVE: Gabapentin immediate release (GBP-IR), gabapentin gastric retentive (GBP-GR), and the prodrug gabapentin enacarbil extended release formulation (GEn) have been approved for management of postherpetic neuralgia (PHN) in adults. This is the first pharmacokinetic (PK) comparison of all three formulations using FDA-recommended doses for PHN. MATERIALS: This study compared the steady-state PK of GBP-IR 600 mg t.i.d., GBP-GR 1,800 mg q.d., and GEn 600 mg b...
April 10, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29628024/the-association-between-cyp2c9-2c19-polymorphisms-and-phenytoin-maintenance-doses-in-asian-epileptic-patients-a-systematic-review-and-meta-analysis
#10
Kai Liao, Yong Liu, Chun-Zhi Ai, Xi Yu, Wei Li
OBJECTIVE: Therapeutic response to phenytoin (PHT), a first-line antiepileptic drug (AED), is highly variable, in part likely due to genetic factors. Genetic polymorphisms in cytochrome P450 (CYP) 2C9 and CYP2C19 are expected to affect the metabolism of PHT and consequently affect its maintenance doses. We aimed to clarify the effects of genetic polymorphisms in both enzymes on daily PHT maintenance dosage in Asian epileptic patients by meta-analysis. MATERIALS AND METHODS: A systematic literature search was conducted in PubMed and EMBASE for relevant studies published prior to April 14, 2017...
April 9, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29628023/effects-of-erythropoietin-on-the-clinical-outcomes-of-patients-with-acute-st-segment-elevation-myocardial-infarction-after-percutaneous-coronary-intervention-a-meta-analysis
#11
Hai-Tao Yang, Wen-Juan Xiu, Ying-Ying Zheng, Yi-Tong Ma, Xiang Xie
AIMS: To investigate the effects of erythropoietin (EPO) on the clinical outcomes of patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). MATERIAL AND METHODS: We collected randomized controlled studies conducted before April 15, 2017, and performed a meta-analysis using RevMan5.3 software. RESULTS: Compared with the conventional revascularization group, mortality (RR = 0...
April 9, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29595123/investigation-of-potential-drug-drug-interaction-between-salbutamol-and-ambroxol-and-bioequivalence-of-a-new-fixed-dose-combination-formulation-containing-two-drugs-in-healthy-chinese-subjects
#12
Yan Wang, Jin Lu, Tengfei Li, Shunbo Zhao, Wen Yang, Lingye Liu, Xing Shi, Li Ding
OBJECTIVES: The aims of the study were to investigate the potential drug-drug interaction between salbutamol and ambroxol, the bioequivalence of the new fixed-dose combination containing salbutamol and ambroxol compared with co-administration of the two separate formulations, and to describe the safety and tolerability of the fixed-dose combination formulation in healthy Chinese volunteers. MATERIALS AND METHODS: An open-label, single-dose, four-treatment, four-period crossover study for evaluation of drug-drug interaction and bioequivalence (n = 24) was performed...
March 29, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29595122/population-pharmacokinetics-and-pharmacodynamics-of-fondaparinux-in-japanese-patients-after-artificial-total-knee-replacement
#13
Kazuhiko Hanada, Soichi Shibata, Yuki Takashima, Takuma Matsuo, Keisuke Iwa, Hajime Matsubara, Yasunori Tsukimura, Harumi Takahashi
OBJECTIVE: This study was designed to clarify the factors affecting the efficacy, adverse events, and pharmacokinetics of fondaparinux in Japanese patients undergoing artificial knee replacement surgery. MATERIALS AND METHODS: Fondaparinux (1.5 mg/d) was administered subcutaneously to patients (n = 30) at 24 hours after surgery, and blood samples were taken at various time points thereafter. Venous thromboembolism (VTE), presence of bleeding, and pharmacokinetics were evaluated...
March 29, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29578394/comparative-efficacy-and-safety-of-tumor-necrosis-factor-inhibitor-plus-methotrexate-versus-oral-triple-therapy-in-patients-with-active-rheumatoid-arthritis-that-inadequately-responds-to-methotrexate-a-meta-analysis-of-randomized-controlled-trials
#14
Sang-Cheol Bae, Young Ho Lee
AIMS: The study aimed to assess the efficacy and safety of tumor necrosis factor inhibitor (TNFI) with methotrexate (MTX) vs. oral triple therapy in patients with active rheumatoid arthritis (RA), showing inadequate response to MTX. MATERIALS AND METHODS: We performed a meta-analysis of three randomized controlled trials (RCTs) (913 MTX-resistant RA patients) to examine the relative efficacy and safety of TNFI+MTX compared to triple therapy (hydroxychloroquine, sulfasalazine, MTX) in patients with RA responding inadequately to MTX...
March 26, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29578393/prevalence-and-predictors-of-tricyclic-antidepressant-use-in-primary-care-and-specialty-clinics-among-the-korean-elderly
#15
Jung Eun Hwang, Inmyung Song, Eui-Kyung Lee, Dongmun Ha, Ju-Young Shin
OBJECTIVES: Tricyclic antidepressants (TCAs) are prescribed with caution in the elderly due to diverse side effects. We analyzed the patterns of TCA use in elderly patients in primary-care and specialty clinics and investigated factors influencing TCA prescriptions. MATERIALS AND METHODS: Elderly patients (≥ 65 years old) prescribed antidepressants in primary-care clinics in 2013 were included from the Health Insurance Review and Assessment Service-Aged Patient Sample (HIRA-APS)...
March 26, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29451470/use-of-integrated-clinical-trial-protocols-a-survey-in-early-medicines-development
#16
Katharina Erb-Zohar, Hildegard Sourgens, Kerstin Breithaupt-Groegler
PURPOSE: To collect information on the use of integrated protocols in early clinical medicines development. MATERIALS AND METHODS: The questionnaire was mailed in fall 2014 to members of human pharmacology societies in Europe for anonymous responses via the online tool SurveyMonkey<sup>®</sup>. RESULTS: 97 respondents reported on 164 integrated protocols overall. In general, integrated protocols comprised 2 or 3 trial elements...
May 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29393850/voriconazole-therapeutic-drug-monitoring-factors-associated-with-supratherapeutic-and-subtherapeutic-voriconazole-concentrations
#17
Haisheng You, Yuzhu Dong, Yamin Zou, Tao Zhang, Jin'e Lei, Limei Chen, Xue Wang, Yalin Dong, Taotao Wang
OBJECTIVE: The voriconazole trough concentration (C<sub>min</sub>) varies widely, and C<sub>min</sub> outside the therapeutic range (COTR) is associated with response failure and toxicity. The objective of this study was to identify potential factors associated with COTR in patients, and specifically the population at a high risk of COTR. MATERIALS AND METHODS: We performed a retrospective study of patients who received voriconazole from 2009 to 2016...
May 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29393849/prevalence-and-treatment-of-sexually-transmitted-diseases-in-gynecological-practices-in-germany-a-retrospective-study-with-more-than-1-000-000-patients
#18
Louis Jacob, Franziska Böhler, Matthias Kalder, Karel Kostev
BACKGROUND: The aim of this study was to analyze the prevalence and treatment of sexually transmitted diseases (STDs) in gynecological practices in Germany. MATERIALS AND METHODS: This study included women who were followed in gynecological practices in Germany between 2013 and 2015. The first outcome was the prevalence of women diagnosed with STDs during this time period. Eight different types of STD infections were included in the analysis: chlamydial infection, gonococcal infection, anogenital warts, anogenital herpes infection, trichomoniasis, ulcus molle, phthiriasis, and syphilis...
May 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29393846/population-pharmacokinetic-model-of-levetiracetam-in-korean-neonates-with-seizures
#19
Yun Seob Jung, Soon Min Lee, Min Soo Park, Kyungsoo Park
OBJECTIVE: This study was conducted to develop a population pharmacokinetic (PK) model of levetiracetam in Korean neonates with seizures. MATERIALS AND METHODS: Data were obtained from a retrospective study of 18 neonates with seizures admitted to the Neonatal Intensive Care Unit (NICU) of Severance Children's Hospital for the period of from 2013 to 2015. Sampling and dosing times were recorded by clinical research coordinators on case report forms. Demographic factors and laboratory results were tested as potential covariates for PK parameters...
May 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29451469/evaluation-of-the-warming-sensation-acceptability-and-local-tolerability-of-an-acetylcysteine-oral-solution-containing-the-flavoring-agent-iff-flavor-316282-in-the-treatment-of-productive-cough
#20
Frank Donath, Anna Grinienko, Pascal Mallefet, Michel Jean-Pierre Ozun, Lucy Shneyer
OBJECTIVE: This open-label study sought to evaluate the warming sensation produced by IFF flavor 316282 in an acetylcysteine oral solution in subjects with productive cough. MATERIALS: 2% ace-tylcysteine oral solution (200 mg per 10 mL) containing IFF flavor 316282. METHODS: Subjects (N = 57; mean age 38.7 years; 58% female) with a productive cough lasting < 7 days and rated as mild to moderate in severity received 10 mL of study product...
April 2018: International Journal of Clinical Pharmacology and Therapeutics
journal
journal
31654
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"