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International Journal of Clinical Pharmacology and Therapeutics

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https://www.readbyqxmd.com/read/29092734/predictors-of-functional-outcome-and-hemorrhagic-complications-in-acute-ischemic-stroke-patients-treated-with-intravenous-thrombolysis-a-retrospective-analysis%C3%A2
#1
Qinqin Zhao, Wenya Shan, Li Liu, Xuchun Fu, Ping Liu, Yunzhen Hu
Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) within 4.5 hours is an effective and routine therapy for acute ischemic stroke (AIS). The purpose of the study was to identify predictors of functional outcome at 3 months and hemorrhagic complications after IVT. A total of 123 AIS patients treated with intravenous alteplase within 4.5 hours after stroke were enrolled. Baseline clinical characteristics, medication and disease history, radiographic and laboratory data were collected...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29092733/bortezomib-induced-syndrome-of-inappropriate-antidiuresis-in-a-patient-with-multiple-myeloma-a-case-report-and-literature-review%C3%A2
#2
Bo Peng, Hu Chen, Xiao Lou
Bortezomib is a landmark drug in the therapeutic history of multiple myeloma as the first-generation proteasome inhibitor. It is widely used clinically, and its common adverse reaction is peripheral nerve lesion. We observed a severe syndrome of inappropriate antidiuresis (SIAD) in a female patient with multiple myeloma treated with bortezomib. This paper reviews the treatment process and relevant research progress regarding SIAD through a case report so as to improve the clinicians' ability to recognize and diagnose this rare complication...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29092732/searching-for-factors-that-may-reduce-the-use-of-benzodiazepines-in-hospitals-a-survey-of-hospital-doctors-and-nurses%C3%A2
#3
Stephanie Heinemann, Wolfgang Himmel
A chart review at a mid-sized German general hospital found a high usage of benzodiazepines among older patients. Therefore, all doctors and nurses of this hospital were surveyed about the benefits and risks of benzodiazepines that they considered to be the strongest and their own overall assessment of the risk-benefit ratio for their patients Response rate was 54% (63/116) for doctors and 30% (73/243) for nurses. "Reduced fear or agitation" was perceived by many doctors (71%) and nurses (49%) to be a strong benefit of benzodiazepines...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29092731/bioequivalence-of-cyclobenzaprine-hydrochloride-extended-release-capsule-taken%C3%A2-intact-or-sprinkled-over-applesauce%C3%A2
#4
Liat Adar, William Zarycranski, Jill B Conner, Jeffrey Dragone, Lindsay Janka, Laura Rabinovich-Guilatt
OBJECTIVE: Difficulty swallowing pills can compromise pain control in painful musculoskeletal disorders. This open-label, 2-period crossover study assessed pharmacokinetics and safety of cyclobenzaprine extended-release (CER) 30-mg capsule contents sprinkled over applesauce compared with intact capsules in healthy subjects. MATERIALS AND METHODS: 32 subjects were randomized to treatment sequences AB or BA (A = single CER intact capsule; B = single CER capsule contents sprinkled over applesauce (15 mL))...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29092730/bioequivalence-and-pharmacokinetic-pharmacodynamic-correlation-of-clopidogrel-in%C3%A2-healthy-thai-subjects%C3%A2
#5
Malinee Chunsangchan, Pajaree Chariyavilaskul, Wannarasmi Ketchart, Nantaporn Prompila, Supeecha Wittayalertpanya
Clopidogrel is an antiplatelet drug, selectively binding to the platelet P2Y12 receptor of adenosine diphosphate. Clopidogrel is a prodrug modified through active metabolite in the liver by two steps of CYP enzyme. The active metabolite is responsible for inhibiting platelet aggregation. OBJECTIVE: The study aimed to assess the bioequivalence of clopidogrel 75 mg generic and reference drugs and to investigate the correlation between pharmacokinetics of active metabolites and its antiplatelet activities...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29092729/bioequivalence-and-food-effect-study-of-two-zaltoprofen-preparations-in-healthy-chinese-volunteers%C3%A2
#6
Ying Song, Yi Ding, Yanyan Jia, Jinyi Zhao, Kai Gao, Chengtao Lu, Ruili Li, Aidong Wen
OBJECTIVE: Zaltoprofen, a propionic acid derivative of nonsteroidal anti-inflammatory drug (NSAID), has powerful anti-inflammatory and analgesic effects on inflammatory pain. This study was undertaken to investigate the effect of food on the pharmacokinetic parameters of zaltoprofen capsule (trial preparation, T) and tablet (reference preparation, R), and to assess the relative bioequivalence of two zaltoprofen preparations. MATERIALS AND METHODS: In this open-label, randomized, crossover, two-state, four-period study, 24 healthy Chinese volunteers were randomized to receive a single oral dose of zaltoprofen capsule/tablet (80 mg) under fasting and fed state...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29092728/extensive-gastric-mucosal-atrophy-is-a-possible-predictor-of-clinical-effectiveness-of%C3%A2-acotiamide-in-patients-with-functional-dyspepsia%C3%A2
#7
Atsushi Miki, Takatsugu Yamamoto, Kyohei Maruyama, Naohiro Nakamura, Hitoshi Aoyagi, Akari Isono, Koichiro Abe, Hiroto Kita
BACKGROUND: Acotiamide is known as an effective agent for functional dyspepsia. However, clinical factors related to its effectiveness have not been fully elucidated, so it is difficult to predict the drug's effectiveness prior to its administration in patients. AIMS: The present retrospective study was conducted to examine the relationship between clinical factors and the effectiveness of acotiamide for functional dyspepsia. MATERIALS AND METHODS: The study subjects were 149 patients with functional dyspepsia who were prescribed acotiamide...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28956529/absorption-kinetics-of-flurbiprofen-axetil-microspheres-in-cerebrospinal-fluid-a-pilot-study%C3%A2
#8
Hong Zhang, Jian Gu, Yi Feng, Haiyan An
OBJECTIVE: The purpose of this study is to investigate the absorption dynamics of flurbiprofen axetil in cerebrospinal fluid. MATERIALS AND METHODS: We analyzed the concentrations of flurbiprofen in peripheral venous blood and cerebrospinal fluid (CSF) to explore the absorption dynamics of flurbiprofen axetil loaded in lipid microspheres in CSF. 72 adult patients who planned to undergo selective operations under spinal anesthesia or combined spinal-epidural anesthesia were intravenously injected with flurbiprofen axetil (1 mg/kg) and randomly divided into nine groups according to the sampling time after administration: 5 (T5), 10 (T10), 15 (T15), 20 (T20), 25 (T25), 30 (T30), 35 (T35), 40 (T40), and 45 minutes (T45)...
September 28, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28933338/impact-of-lubiprostone-on-gastric-emptying-profile-and-the-possible-effect-of-concomitant-domperidone-in-healthy-adults%C3%A2
#9
Takayuki Okamura, Takatsugu Yamamoto, Satoshi Kimura, Atsushi Miki, Koichiro Abe, Hiroto Kita
BACKGROUND: Lubiprostone is effective for patients with chronic constipation. This agent sometimes causes upper gastrointestinal symptoms, such as nausea, which is one of the chief reasons for discontinuation. However, the etiology of and strategy against bothersome gastrointestinal symptoms of lubiprostone remain unclear. AIMS: The goal of this study was to investigate the influence of lubiprostone on the gastric-emptying profile of healthy adults. The effect of domperidone on gastric emptying and gastrointestinal symptoms after lubiprostone administration were also assessed...
September 21, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28933337/the-polymorphism-of-cyp2d6-affects-the-pharmacokinetics-and-dose-escalation-of-paroxetine-controlled-release-tablet-in-healthy-chinese-subjects%C3%A2
#10
Rui Chen, Kai Shen, Pei Hu
PURPOSE: This study evaluated the effects of CYP2D6 polymorphisms on the pharmacokinetics and dose escalation of controlled-release paroxetine over the dose range of 12.5 - 37.5 mg in healthy Chinese subjects. MATERIALS AND METHODS: This was a phase I, open-label, single-dose, three-period crossover study in which 12 healthy subjects received single oral doses of 12.5, 25, and 37.5 mg paroxetine controlled-release tablets with 10-day washout between doses. Serial venous blood samples were collected for 96 hours after study-drug administration and analyzed with LC-MS/MS...
September 21, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28933336/bioavailability-of-oxycodone-after-administration-of-a-new-prolonged-release-once-daily-tablet-formulation-in-healthy-subjects-in-comparison-to-an-established-twice-daily-tablet%C3%A2
#11
Bernhard Scheidel, Martina A Maritz, Yves J Gschwind, Kerstin Steigerwald, Volker Guth, Peter Kovacs, Helene Rey
OBJECTIVE: To evaluate and to compare the bioavailability, the influence of food intake on the bioavailability, and the safety and tolerability of a newly-developed oxycodone once-daily (OOD) prolonged-release tablet with an established oxycodone twice-daily (OTD) prolonged-release tablet after single-dose administration under fasting or fed conditions as well as after multiple-dose administration. MATERIALS AND METHODS: Three single-center, open-label, randomized, balanced, two-treatment, two-period, two-sequence crossover studies were conducted...
September 21, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28853698/prioritization-of-diseases-for-the-development-of-a-pharmaceutical-care-service-model-in-south-korea-using-the-analytic-hierarchy-process%C3%A2
#12
Kiyon Rhew, Nayoung Han, Keun-Tae Cho, Jeong-Hyun Yoon, Jung Mi Oh
OBJECTIVE: Drug therapy plays a critical role in most chronic diseases. Effectiveness of pharmaceutical care services in the improvement of clinical, social, or economic outcomes has been scientifically proven through numerous studies. In South Korea, to optimize and standardize pharmaceutical care for patients with chronic metabolic diseases, the development of a pharmaceutical care service model is needed. MATERIALS: To determine the priority of diseases in developing pharmaceutical care service models, analytic hierarchny process (AHP)analysis was used...
August 30, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28853697/analysis-of-inappropriate-medication-use-and-drug-interactions-in-older-people-in-south-korea%C3%A2
#13
Hyunah Kim, Hun-Sung Kim, Hyerang Ko, Jia Choi, Nam Cho
OBJECTIVES: Medication use in older people has been increasing as the incidence of chronic diseases increases worldwide. The objective of this study was to assess potentially inappropriate medications (PIMs) and potential drug-drug interactions (pDDIs) to improve the rational use of medications in this population. MATERIALS AND METHODS: In this large, cross-sectional study, data on older people from a regional community obtained during health examinations in 2013 - 2014 were analyzed...
August 30, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28816111/updated-2014-stopp-criteria-to-identify-potentially-inappropriate-prescribing-in-community-dwelling-elderly-patients%C3%A2
#14
María Luisa Nicieza-Garcia, Gloria Manso, Esther Salgueiro
OBJECTIVE: To analyze potentially inappropriate prescribing (PIP) using the 2014 version of STOPP criteria. MATERIALS AND METHODS: Prescriptions were analyzed by using invoicing data and electronic medical records. RESULTS: At least one STOPP criterion was observed in 9 out of every 10 patients. The most common STOPP criteria found were: "any drug prescribed without an evidence-based clinical indication" and "any drug prescribed beyond the recommended duration, where treatment duration is well defined"...
October 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28793958/pharmacokinetics-and-relative-bioavailability-of-a-generic-amisulpride-tablet-in-healthy-chinese-volunteers%C3%A2
#15
Si-Si Cao, Yan-Xia Ma, Ping-Fei Fang, Hua-Lin Cai, Yang Deng, Zhen-Yan Hou, Ying Chen, Miao Yan, Bi-Kui Zhang
OBJECTIVE: To assess and compare the pharmacokinetic properties and bioavailability of a newly developed formulation of amisulpride with those of a conventional formulation in healthy Chinese volunteers under fasting state. MATERIALS AND METHODS: A single-dose, two-sequence crossover study was designed. 20 healthy subjects (14 males and 6 females) were randomized into two groups. A single oral dose of amisulpride (200 mg) was given after an overnight fast of 12 hours...
October 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28793956/hypersensitivity-reaction-to-%C3%AE-lactam-antibiotics-in-patients-with-adult-t-cell-leukemia-lymphoma-treated-with-mogamulizumab%C3%A2
#16
Takeo Yasu, Yoichi Imai, Nobuhiro Ohno, Kaoru Uchimaru, Yosuke Kurokawa, Arinobu Tojo
Mogamulizumab (MOG) is a humanized anti-CCR4 monoclonal antibody that is highly cytotoxic for adult T-cell leukemia/lymphoma (ATL) cells. Most non-hematological adverse events are cutaneous adverse reactions in ATL patients. We reviewed the medical records of 24 patients with CCR4-positive aggressive ATL who had received MOG treatment. The incidence of MOG-induced cutaneous adverse reactions (MCARs) was 25% (6 patients). Four patients with MCAR had an interesting clinical course, compared with MCARs reported in previous reports...
October 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28766500/a-bioequivalence-study-of-two-memantine-formulations-in-healthy-chinese-male-volunteers%C3%A2
#17
Ying Deng, Jialang Zhuang, Jingguo Wu, Jiangying Chen, Liang Ding, Xueding Wang, Lihui Huang, Guixiong Zeng, Jie Chen, Zhongfu Ma, Xiao Chen, Guoping Zhong, Min Huang, Xianglan Zhao
OBJECTIVE: The aim of the current study is to evaluate the bioequivalence between the test and reference formulations of memantine in a single-dose, two-period and two-sequence crossover study with a 44-day washout interval. MATERIALS AND METHODS: A total of 20 healthy Chinese male volunteers were enrolled and completed the study, after oral administration of single doses of 10 mg test and reference formulations of memantine. The blood samples were collected at different time points and memantine concentrations were determined by a fully validated HPLC-MS/MS method...
October 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28766499/association-between-platelet-function-and-recurrent-ischemic-vascular-events-after-tia%C3%A2-and-minor-stroke%C3%A2
#18
Jinbiao Zhang, Jiangshan Zhang, Hairong Sun, Tan Ming, Xinwu Liu, Yannan Cong, Fang Li, Zhenguang Li
Platelet activation and aggregation play an important role in the pathological and physiological processes of recurrent ischemic vascular events in stroke patients. The purpose of this study is to determine the association between platelet function measured in the acute period and recurrent ischemic vascular events in patients with transient ischemic attack (TIA) or minor stroke. A total of 417 patients who were within the 24-hour period of clopidogrel-aspirin therapy after onset of a minor stroke or high-risk transient ischemic attack according to the Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial were included in this study...
October 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28766498/comparison-of-first-and-second-generation-antihistamine-prescribing-in-elderly-outpatients-a-health-insurance-database-study-in-2013
#19
Young-Mi Lee, Inmyung Song, Eui-Kyung Lee, Ju-Young Shin
BACKGROUND: This descriptive study analyzed the scale of first- and second-generation antihistamine prescription in elderly outpatients in Korea and the characteristics associated with this prescription. MATERIALS AND METHODS: We conducted a drug utilization study using the Korea Health Insurance Review and Assessment Service-Aged Patient Sample (HIRA-APS) database from January 1 to December 31, 2013. The study subjects were elderly outpatients aged 65 years and older who were prescribed antihistamines...
October 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28766497/predictive-factors-for-the-effect-of-acid-reducing-agents-on-drug-exposure
#20
Masahiko Sato, Mamoru Narukawa
OBJECTIVES: Acid-reducing agents (ARAs) may affect drug exposure for orally-administered drugs exhibiting pH-dependent solubility. The aim of this research was to investigate factors predicting the effect of ARAs on drug exposure. Dose (mg)/250 mL/solubility at neutral pH and ratio of solubility at acidic pH to that at neutral pH were investigated as potential factors. MATERIALS AND METHODS: Drug-drug interaction (DDI) study results with ARAs were selected based on PubMed search from 2007 to 2016 and novel drug approvals at the US Food and Drug Administration (FDA) from 2014 to 2016...
October 2017: International Journal of Clinical Pharmacology and Therapeutics
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