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Neuroimmunomodulation

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https://www.readbyqxmd.com/read/28535535/inflammation-is-an-important-covariate-for-the-crosstalk-of-sleep-and-the-hpa-axis-in-rheumatoid-arthritis
#1
Rainer H Straub, Jaqueline Detert, René Dziurla, Ingo Fietze, Peter-Andreas Loeschmann, Gerd R Burmester, Frank Buttgereit
Rheumatoid arthritis (RA) patients have sleep problems, and inflammation influences sleep. We demonstrated that sleep quality improves during intensified treatment with methotrexate (MTX) or etanercept (ETA). Since the hypothalamic-pituitary-adrenal (HPA) axis is involved in sleep regulation, this study investigated the interrelation between sleep parameters, inflammation as objectified by C-reactive protein (CRP), and serum cortisol and adrenocorticotropic hormone (ACTH) levels. Thirty-one eligible patients (disease activity score, DAS28CRP ≥3...
May 24, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28478458/acute-lipopolysaccharide-switches-the-selection-of-maternal-behavior-to-predatory-behavior-in-female-rats
#2
Tiberiade Mendes-Lima, Thiago Berti Kirsten, Luciano Freitas Felicio, Elizabeth Teodorov, Nicolle Queiroz-Hazarbassanov, Maria Martha Bernardi
OBJECTIVES: A common problem during the postpartum period and during lactation is being affected by infection due to Gram-negative bacteria. In this situation, a sick mother needs to choose between caring for her pups or the need for survival. This study analyzed the effects of lipopolysaccharide (LPS)-induced sickness behavior on selection between maternal behavior (MB) and predatory behavior (PB) in lactating rats. To assess the LPS-induced sickness behavior, the plasma tumor necrosis factor-α (TNF-α) levels were measured...
May 6, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28445879/cytokine-and-chemokine-profiles-in-patients-with-neuromyelitis-optica-spectrum-disorder
#3
Yuge Wang, Yifan Zhou, Xiaobo Sun, Tingting Lu, Lei Wei, Ling Fang, Chen Chen, Qiao Huang, Xueqiang Hu, Zhengqi Lu, Lisheng Peng, Wei Qiu
OBJECTIVE: To screen cytokines and chemokines and determine their dynamic changes in the serum and cerebrospinal fluid (CSF) of patients with neuromyelitis optica spectrum disorder (NMOSD). METHODS: Eight NMOSD with seropositive aquaporin-4 antibody (AQP4-IgG) were enrolled, as well as 8 matched patients with multiple sclerosis (MS) and 8 with noninflammatory neurological diseases, who were included as controls. In total, 102 cytokines and 34 chemokines were detected in the CSF and serum of NMOSD patients and controls...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28433998/interferon-%C3%AE-1a-modulates-expression-of-rage-but-not-s100a12-and-nuclear-factor-%C3%AE%C2%BAb-in-multiple-sclerosis-patients
#4
Gholamreza Asadikaram, Saam Noroozi, Hossein Ali Ebrahimi Meimand, Mojgan Sanjari, Nahid Zainodini, Hossein Khoramdelazad, Nader Shahrokhi, Mohammad Kazemi Arababadi
OBJECTIVES: Interferon-β 1a (IFN-β 1a) is a common strategy therapy for multiple sclerosis (MS) with unknown mechanisms. S100A12 (S100 calcium-binding protein A12) is a damage-associated molecular pattern molecule which binds to its receptor, RAGE (receptor for advanced glycation end products), and activates nuclear factor-κB (NF-κB). NF-κB is transcribed from proinflammatory molecules, which may participate in the pathogenesis of MS. Therefore, the aims of this study were to compare mRNA levels of S100A12, RAGE, and NF-κB in newly diagnosed MS patients with healthy controls and determine whether IFN-β 1a therapy affects the expression of the molecules...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28427055/aquaporin-4-mediates-the-suppressive-effect-of-lipopolysaccharide-on-hippocampal-neurogenesis
#5
Rui Liang, Shoulei Yong, Xu Huang, Hui Kong, Gang Hu, Yi Fan
OBJECTIVE: Aquaporin-4 (AQP4), a key molecule for water homeostasis in the brain, is associated with adult neurogenesis, but its mechanisms regulating adult neural stem cells (aNSC) remain largely unexplored. Neuroinflammation has a relevant influence on adult neurogenesis, which is a common feature in various neurodegenerative diseases. Considering the possible link between neuroinflammation and AQP4, we speculate that AQP4 may mediate the synthesis and release of proinflammatory cytokines in glia and then indirectly regulate adult hippocampal neurogenesis...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28419991/effect-of-melatonin-and-resveratrol-against-memory-impairment-and-hippocampal-damage-in-a-rat-model-of-vascular-dementia
#6
Dongfang Shen, Xiaoyan Tian, Wenxu Sang, Rongrong Song
OBJECTIVES: This study was intended to investigate whether treatment with resveratrol and melatonin alone or in combination can exert neurorestorative effects in a rat model of vascular dementia. METHODS: Briefly, male Wistar rats were subjected to permanent bilateral common carotid artery occlusion (BCCAO) by surgery. After 4 weeks, the cognitive deficits were assessed using the Morris water maze and novel object recognition tests. The biochemical parameters of oxidative stress and inflammation were also assessed...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28395287/interleukin-1%C3%AE-plays-a-pivotal-role-via-the-pi3k-akt-mtor-signaling-pathway-in-the-chronicity-of-mesial-temporal-lobe-epilepsy
#7
Zhaohua Xiao, Jing Peng, Na Gan, Ahmed Arafat, Fei Yin
OBJECTIVE: Mesial temporal lobe epilepsy (MTLE) is the most common type of refractory epilepsy. It is often associated with hippocampal sclerosis, which is histopathologically characterized by selective neuron loss, mossy fiber sprouting, and synapse reconstruction, and is the primary cause of refractory epilepsy. Its mechanism has not been fully elucidated. Substantial evidence now supports that inflammatory pathways are activated in epilepsy foci. We have confirmed that the interleukin-1β (IL-1β) level is involved in the epileptogenesis of MTLE, and we further investigated how it works in its chronicity in this study...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28395279/serum-lymphocyte-associated-cytokine-concentrations-change-more-rapidly-over-time-in-multiple-system-atrophy-compared-to-parkinson-disease
#8
Keri Csencsits-Smith, Jessika Suescun, Kan Li, Sheng Luo, Diane L Bick, Mya Schiess
OBJECTIVE: Chronic inflammatory processes contribute to the eventual death of motor neurons and the development of symptoms in both idiopathic Parkinson disease (PD) and multiple system atrophy (MSA). Given the faster rate of progression and more severe symptoms associated with MSA, we hypothesized that markers of inflammation would be more evident in the peripheral blood of MSA than PD patients, and that evidence of this inflammation might assist early diagnosis of MSA versus PD. METHODS: We performed multiplex analysis to determine the concentrations of 37 immune-associated cytokines and chemokines isolated from the plasma of patients with PD (n = 25) and MSA (n = 14) and compared our results to those of age-matched controls (n = 15)...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28391264/anti-kir4-1-antibodies-in-chinese-patients-with-central-nervous-system-inflammatory-demyelinating-disorders
#9
Rong Zhong, Junyan Liang, Ailin Tao, Linzhan Wu, Xinguang Yang, Huiming Xu, Qingmei Huang, Shunzhi Zhuang, Youming Long, Cong Gao
OBJECTIVES: The aim of this study was to explore the frequency of KIR4.1 antibodies in patients with multiple sclerosis (MS) and in control groups using a cell-based assay. MATERIALS AND METHODS: A transfected HEK-293A cell line expressing KIR4.1 was established to test for the presence of KIR4.1 antibodies in blood serum. We tested 904 subjects, including 188 patients with MS, 264 patients with neuromyelitis optica spectrum disorders (NMOSD), 209 patients with other inflammatory neurologic disease (OIND), 203 patients with other noninflammatory neurological disease (OND), and 40 healthy controls...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28249276/hair-cortisol-concentrations-are-associated-with-hair-growth-rate
#10
Lianbin Xiang, Imran Sunesara, Kristina E Rehm, Gailen D Marshall
There is a growing interest in hair cortisol concentrations as a valuable biomarker for the assessment of metabolic diseases and chronic psychological stress. Fifty-three volunteers were recruited, and hair segments proximal to the scalp were collected from each individual. A cost-effective ball mill was used for the preparation of hair samples, and ELISA was performed to analyze cortisol concentrations. Results indicate that the frequency of hair washing affects the hair cortisol concentration. The group that washed their hair every day had significantly lower cortisol concentrations than the group that washed it less often...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28208151/bacillus-calmette-gu%C3%A3-rin-confers-neuroprotection-in-a-murine-model-of-japanese-encephalitis
#11
Sahil Kulkarni, Sandeepan Mukherjee, Anupama Pandey, Ritwik Dahake, Usha Padmanabhan, Abhay S Chowdhary
OBJECTIVE: Japanese encephalitis (JE) is a debilitating disease caused by infection with the JE virus (JEV; family: Flaviviridae), which leaves neurological sequelae in survivors but more often leads to mortality. Neurodegeneration caused by inflammation is the primary pathology behind the clinical manifestation of encephalitis caused by JEV. Bacillus Calmette-Guérin (BCG) has been used in immunoprophylaxis for tuberculosis and in the adjuvant therapy of many malignancies, and has exhibited neuroprotective activities in experimental models of Parkinson and Alzheimer disease...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28095390/hydrogen-sulfide-promotes-learning-and-memory-and-suppresses-proinflammatory-cytokines-in-repetitive-febrile-seizures
#12
Fei Zhuang, Xuhong Zhou, Hong Li, Xiaochun Yang, Zewu Dong, Wendi Zhou, Jian Chen
OBJECTIVE: Hydrogen sulfide (H2S), as a novel gasotransmitter, plays important roles in a number of physiological and pathological processes. Its effectiveness has been demonstrated in different types of brain disorders but not in repetitive febrile seizure (febrile status epilepticus; FSE) models. This study aims to test whether a donor of H2S sodium sulfhydrate (NaHS) is also effective for FSE in rats. METHODS: FSE was induced in rat pups on postnatal day 10 in water at 45...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28030866/increase-of-mast-cell-nerve-association-and-neuropeptide-receptor-expression-on-mast-cells-in-perennial-allergic-rhinitis
#13
Duc Dung Le, David Schmit, Sebastian Heck, Albert Joachim Omlor, Martina Sester, Christian Herr, Bernhard Schick, François Daubeuf, Sebastian Fähndrich, Robert Bals, Nelly Frossard, Basel Al Kadah, Quoc Thai Dinh
OBJECTIVES: Mast cells (MCs) and nerves play an important role in allergic rhinitis (AR), but little is known about their crosstalk in AR. The aim of this study was to investigate MC-nerve interaction in the human nasal mucosa during AR. METHODS: The association between MCs and nerves, the expression of neuropeptide receptors (neurokinin 1 receptor [NK1R], neurokinin 2 receptor [NK2R], calcitonin gene-related peptide receptor [CGRPR], and MrgX2) on MCs, and protease-activated receptor 2 (PAR2) and tyrosine receptor kinase A (TrkA) on nerve fibres in the human nasal mucosa were investigated with immunofluorescence and real-time PCR...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27931030/effects-of-total-sleep-deprivation-on-mouse-cytokine-levels
#14
Lin Yang, Li Li, Jianfeng Xue
OBJECTIVE: Cytokines play an integral role in sleep/wake regulation. The objective of this study was to identify how total sleep deprivation affects cytokine levels. METHODS: Male C57BL/6 mice were subjected to 48 h of total sleep deprivation produced by brief rotation of activity wheels or 3 different controls: home cage, a sedentary wheel, or forced activity. In addition, the serum levels of cytokines were analyzed using a mouse magnetic bead-based multiplex immunoassay...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27931028/sustained-effects-of-neonatal-systemic-lipopolysaccharide-on-il-1%C3%AE-and-nrf2-in-adult-rat-substantia-nigra-are-partly-normalized-by-a-spirulina-enriched-diet
#15
Jaspal Patil, Ashok Matte, Hans Nissbrandt, Carina Mallard, Mats Sandberg
BACKGROUND/AIM: Neonatal infection can sensitize the adult substantia nigra (SN) to secondary insults, causing a decrease in antioxidant capacity which may lead to Parkinson's disease in adults. We studied the prolonged effect of systemic infection by (i.p.) administration of lipopolysaccharide (LPS) on interleukin (IL)-1β, the antioxidant regulator nuclear factor-erythroid 2-related factor 2 (Nrf2), and the peroxisome proliferator-activated receptor γ coactivator (PGC)-1α in rat SN...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27902989/plasma-levels-of-leptin-and-adiponectin-in-fragile-x-syndrome
#16
Małgorzata Zofia Lisik, Ewa Gutmajster, Aleksander L Sieroń
Fragile X syndrome (FXS) is the most common form of familial mental retardation and one of the leading known causes of autism. The mutation responsible for FXS is a large expansion of the CGG repeats in the promoter region of the FMR1 gene, resulting in the transcriptional silencing of the gene. Leptin may be considered a cytokine-like hormone with pleiotropic actions since it may be involved in the regulation of neuroendocrine functions and the immune system response, in addition to playing a role in development...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27894110/significant-role-s-of-cxcl12-and-the-sdf-1-3-a-genetic-variant-in-the-pathogenesis-of-multiple-sclerosis
#17
Mojgan Noroozi Karimabad, Soudeh Khanamani Falahati-Pour, Gholamhossein Hassanshahi
Both cellular and molecular components of the immune system are among the substantial factors involved in the pathogenesis of multiple sclerosis (MS). Accumulating evidence confirms that chemokines, as the main members of the immune system, play key roles in the regulation of immune responses. Immune system genetic parameters are believed to influence the onset of immune system-related diseases. Regarding the significant role of the CXCR4/CXCL12 axis in cell differentiation and survival and homing of hematopoietic progenitors to the bone marrow and regulation of neuronal progenitor cell migration in the central nervous system (CNS), genetic factors can cause an increased expression of CXCL12 and induce a vigorous immune response against CNS antigens in MS patients...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27846628/minocycline-suppresses-nlrp3-inflammasome-activation-in-experimental-ischemic-stroke
#18
Yunnan Lu, Guodong Xiao, Weifeng Luo
OBJECTIVE: Minocycline, a tetracycline antibiotic, has shown anti-inflammatory effects in cerebral ischemia and neurodegenerative disease; however, the molecular mechanisms underlying this effect have not been clearly identified. Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1β (IL-1β) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27842309/dr-james-matthew-lipton-1938-2016
#19
(no author information available yet)
No abstract text is available yet for this article.
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27820940/activated-phosphorylated-stat1-levels-as-a-biologically-relevant-immune-signal-in-schizophrenia
#20
Rajiv P Sharma, Cherise Rosen, Jennifer K Melbourne, Benjamin Feiner, Kayla A Chase
OBJECTIVE: Activation of STAT1 is directly downstream of the cytokine receptors that signal from specific proinflammatory cytokines known to be dysregulated in schizophrenia (SZ), such as IFNγ, IL6, IL2 and IL10, as well as hypoxia, viral/bacterial infections and peptide growth factors. If the increased cytokine protein levels repeatedly observed in SZ have biological consequences, then the measurement of pSTAT1 is a logical step forward. METHODS: Peripheral blood mononuclear cells (PBMCs) from controls (n = 13) and subjects with SZ (n = 22) were extracted using the Ficoll method...
2016: Neuroimmunomodulation
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