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Neuroimmunomodulation

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https://www.readbyqxmd.com/read/29680839/decreased-migration-of-dendritic-cells-into-the-jugular-nodose-ganglia-by-the-cxcl12-neutraligand-chalcone-4-in-ovalbumin-sensitized-asthmatic-mice
#1
Sebastian Heck, François Daubeuf, Duc Dung Le, Martina Sester, Dominique Bonnet, Robert Bals, Nelly Frossard, Quoc Thai Dinh
OBJECTIVE: The chemokine CXCL12 interacting with the CXC receptor 4 (CXCR4) has been reported to play a role in the development and progression of bronchial asthma, but its mechanism of action is still unknown. The objective of this study was to assess the effect of the CXCL12 neutraligand chalcone 4 on the migration of dendritic cells (DCs) in a murine model of allergic airway inflammation. METHODS: A 21-day ovalbumin (OVA)-induced allergic-airway TH2 inflammation model in BALB/c mice was used...
April 20, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29669346/tetrahydrocurcumin-provides-neuroprotection-in-experimental-traumatic-brain-injury-and-the-nrf2-signaling-pathway-as-a-potential-mechanism
#2
Guan Wei, Bingji Chen, Qingjiang Lin, Yasong Li, Liangqin Luo, Hefan He, Huangde Fu
The protective effect of tetrahydrocurcumin (THC) after experimental traumatic brain injury (TBI) has been demonstrated, as demonstrated by the inhibition of oxidative stress, mitochondrial dysfunction, and apoptosis. However, the mechanisms underlying this effect are still not well understood. This study was to investigate the neuroprotective effects of THC, and its potential mechanisms, in a rat model of TBI. To this end, rats were divided into 4 groups: the sham group, the TBI group, the TBI + vehicle (V) group, and the TBI + THC group...
April 18, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29621768/protective-role-of-the-hepatic-vagus-nerve-against-liver-metastasis-in-mice
#3
Tetsuya Hiramoto, Kazufumi Yoshihara, Yasunari Asano, Nobuyuki Sudo
OBJECTIVE(S): Although accumulating evidence has shown that the autonomic nervous system is involved in liver pathology, its role in regulating cancer development remains unclear. The purpose of this study was to elucidate its detailed mechanisms. METHODS: A mouse model of liver metastasis of colorectal cancer was used. To elucidate the potential mechanisms involved, we examined the effect of selective hepatic vagotomy on the survival rate and liver-to-body weight...
April 5, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29617700/vasoactive-intestinal-peptide-protects-salivary-glands-against-structural-injury-and-secretory-dysfunction-via-il-17a-and-aqp5-regulation-in-a-model-of-sj%C3%A3-gren-syndrome
#4
Chengyin Li, Fenglin Zhu, Bin Wu, Yue Wang
OBJECTIVE: Sjögren syndrome (SS) is an autoimmune disease involving exocrine glands. Currently, drugs that can improve both abnormal immunity and exocrine gland function are needed. The study aimed to investigate the effect and mechanism of vasoactive intestinal peptide (VIP) on the immune response and exocrine gland function in SS. METHODS: We investigated the effects of VIP on the immune response and secretory function of submandibular glands using NOD mice, and analyzed the expression of IL-17A and AQP5 (aquaporin 5)...
April 4, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29597198/exercise-induced-change-in-plasma-il-12p70-is-linked-to-migraine-prevention-and-anxiolytic-effects-in-treatment-na%C3%A3-ve-women-a-randomized-controlled-trial
#5
Arão Belitardo Oliveira, Andre Luis Lacerda Bachi, Reinaldo Teixeira Ribeiro, Marco Túlio Mello, Mauro Vaisberg, Mario Fernando Prieto Peres
OBJECTIVE: To conduct a randomized controlled trial to evaluate the effect of a 12-week aerobic exercise program for migraine prevention, plasma cytokines concentrations (TNF-α, interleukin [IL]-1β, IL-6, IL-8, IL-10, and IL-12p70), and anxiety in women with migraine. METHODS: Women with episodic migraine (ICHD-II), aged between 20 and 50 years, who had never taken any prophylactic medication, and were physically inactive in the past 12 months were recruited from the university's hospital and a tertiary headache clinic between March 2012 and March 2015...
March 29, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29558759/vitamin-b12-in-association-with-antipsychotic-drugs-can-modulate-the-expression-of-pro-anti-inflammatory-cytokines-in-alzheimer-disease-patients
#6
Alireza Vakilian, Seyed Moein Razavi-Nasab, Ali Ravari, Tayebeh Mirzaei, Amir Moghadam-Ahmadi, Nazanin Jalali, Reza Bahramabadi, Mohammadtaghi Rezayati, Amin Yazdanpanah-Ravari, Farhad Bahmaniar, Mohammad Reza Bagheri, Mahmood Sheikh Fathollahi, Gholamreza Asadikaram, Mohammad Kazemi Arababadi
INTRODUCTION: Patients with Alzheimer disease (AD) suffer from psychotic symptoms including pain. The current antipsychotic drugs confer limited effectiveness, and hence new strategies are being designed to decrease pain in order to increase antipsychological effectiveness. Vitamin B12 is a safe supplementary drug to decrease pain. Additionally, cytokines participate in the pathogenesis of immune-related diseases such as AD. Thus, the main aim of this clinical trial study was to determine the effects of treatment with risperidone and quetiapine, as antipsychotic drugs, with and without vitamin B12 on the psychotic symptoms of AD patients and the expression of IL-6, IL-8, tumor growth factor (TGF)-β, tumor necrosis factor (TNF)-α, and endothelin (ET)-1)...
March 20, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29539621/immune-cell-neurotrophin-production-is-associated-with-subcortical-brain-atrophy-in-neuropsychiatric-systemic-lupus-erythematosus-patients
#7
Alicja Kalinowska-Łyszczarz, Mikołaj A Pawlak, Aleksandra Wyciszkiewicz, Katarzyna Pawlak-Buś, Piotr Leszczyński, Mariusz Puszczewicz, Włodzimierz Paprzycki, Wojciech Kozubski, Sławomir Michalak
OBJECTIVE: Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) remains poorly understood. Damage within the CNS is driven by the autoimmune response; however, immunopathophysiology of neuropsychiatric (NP) SLE is multifactorial. Immune cell neurotrophin production could be neuroprotective against autoimmunity-driven CNS damage, as has been shown in multiple sclerosis. The aim of this study was to establish whether immune cell neurotrophin production is associated with damage severity in NPSLE...
March 14, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29161707/a-novel-animal-model-simulating-the-beginning-of-combat-exposure
#8
Dongsoo Kim, Chang Yul Kim, Hyojin Koo, Yong Heo, Kicheol Cheon
OBJECTIVE: Predator stress, social defeat stress, and fear conditioning animal models have been applied to investigate combat-related posttraumatic stress disorder (PTSD). However, no animal model psychopharmacological studies have investigated prevention of somatization of increased mental stress and fatigue at the beginning of combat exposure. This study utilized a novel animal model simulating the beginning of combat exposure that aided specification of a set of biomarkers. METHODS: Psychological stress was induced by both inescapable electric foot shock and noise stimuli...
November 22, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29151103/immunoregulatory-role-of-cannabinoids-during-infectious-disease
#9
Rosalía Hernández-Cervantes, Mónica Méndez-Díaz, Óscar Prospéro-García, Jorge Morales-Montor
Although the endocannabinoid system (ECS) is involved in the regulation of several physiological processes, including sleep and the immune response, its role during infections has not been fully studied. It is well known that the use of this drug increases susceptibility to infections because of the impact on the modulation of the immune system. Concerning the medicinal or recreational use of marijuana, its influence on the course of an infection, whether this has been caused by bacteria, viruses, parasites, and to a lesser degree, fungi, has been reported...
November 18, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29145213/depressed-immune-responses-and-accelerated-splenic-apoptosis-due-to-experience-of-food-deprivation-and-inequality-but-not-unstable-social-status-in-balb-c-mice
#10
Marjan Aghajani, Mohammad Reza Vaez Mahdavi, Mohsen Khalili Najafabadi, Tooba Ghazanfari, Fatemeh Moradi, Ravieh Golchoobian, Hasan Askari, Nima Sanadgol, Ehsan Kazemi Moghaddam
OBJECTIVE(S): We aimed to show that the immune system is sensitive to the detrimental effects of inequality and social injustice, and splenic vulnerability to apoptosis may also increase. METHODS: In order of better determination of immune responses to chronic social stress, we implemented food deprivation, food intake inequality, and unstable social status (a change of cage-mate every 3 days) for a period of 14 days in 60 male Balb/c mice. At the end of this stress period, nitric oxide (NO) production by peritoneal adherent cells and the serum concentration of corticosterone were measured...
November 17, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28810246/gper-agonist-g1-attenuates-neuroinflammation-and-dopaminergic-neurodegeneration-in-parkinson-disease
#11
Jing Guan, Beibei Yang, Yi Fan, Ji Zhang
OBJECTIVE: Epidemiological studies have shown that women of reproductive age have much less possibility of developing Parkinson disease (PD) than men. The beneficial effect of estrogen also has been well-described in both culture and animal models of PD. G protein-coupled estrogen receptor (GPER) is a membrane-associated estrogen receptor, and displayed a neuroprotective role in a mouse model of PD. Since GPER is highly expressed in microglia, we speculate that GPER mediates the neuroprotective function of estradiol through suppressing the neuroinflammation of PD...
August 16, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28793299/the-effects-of-adenosinergic-modulation-on-cytokine-levels-in-a-pentylenetetrazole-induced-generalized-tonic-clonic-seizure-model
#12
Fazilet Dede, Sabriye Karadenizli, Özgür Doğa Özsoy, Fatma Ceyla Eraldemir, Deniz Şahin, Nurbay Ateş
OBJECTIVE: It has been suggested that the adenosinergic system and cytokines play a role in the pathogenesis of epilepsy. Although the role of the adenosinergic system in the modulation of seizure activity is well known, the mechanism of this modulation needs to be described in detail. We performed this study to determine the contribution of the proinflammatory cytokines to the generalized seizure activity during adenosine and caffeine treatment. METHODS: We induced generalized tonic-clonic seizures with the administration of 60 mg/kg pentylenetetrazole (PTZ) in male Wistar Albino rats...
August 10, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28787722/beta-adrenergic-blockade-decreases-the-neuroimmune-changes-in-mice-induced-by-cohabitation-with-an-ehrlich-tumor-bearing-cage-mate
#13
Rafael O Margatho, Cristina de O Massoco, Atilio S Calefi, Daniel S G Cruz, Thaisa M Sandini, Glaucie Jussilane Alves, Jorge C Florio, João Palermo-Neto
OBJECTIVES: Cohabitation with Ehrlich tumor-bearing (ETB) mice induced behavioral, neurochemical, hormonal, and immune effects in the conspecifics as a consequence of stress-induced activation of the sympathetic nervous system (SNS) with catecholamine release. In the current study, the nonspecific β-AR blocker d,l-propranolol and the specific β2-AR blocker ICI-118.551 were employed as pharmacological tools to assess the extent to which catecholamines participated in the effects induced by cohabitation with ETB mice...
August 9, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28618410/deletion-of-the-inflammasome-sensor-aim2-mitigates-a%C3%AE-deposition-and-microglial-activation-but-increases-inflammatory-cytokine-expression-in-an-alzheimer-disease-mouse-model
#14
Pei-Jung Wu, Yun-Fen Hung, Hsin-Yu Liu, Yi-Ping Hsueh
OBJECTIVE: Inflammation is clearly associated with Alzheimer disease (AD). Knockout of Nlrp3, a gene encoding an inflammasome sensor, has been shown to ameliorate AD pathology in a mouse model. Because AIM2 is the most dominant inflammasome sensor expressed in mouse brains, here we investigate whether Aim2 deletion also influences the phenotype of a 5XFAD AD mouse model. METHODS: Quantitative RT-PCR, immunostaining, immunoblotting, and behavioral analyses were applied to compare wild-type, Aim2-/-, 5XFAD, and Aim2-/-;5XFAD mice...
June 16, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28614825/effect-of-ceftiofur-on-hyperalgesia-and-allodynia-in-a-rat-neuropathic-pain-model-the-role-of-immune-processes
#15
Aytül Önal, Deniz Coşkunsever, Fatma Gül Çelenk, Recep Selim Şentürk, Selvi Nalbant, Sibel Ülker Göksel
OBJECTIVE: Inflammatory and immune mechanisms play important roles in the pathogenesis of neuropathic pain. Ceftiofur, a third-generation cephalosporin, has anti-inflammatory effects by inhibiting tumor necrosis factor (TNF)-α, interleukin (IL)-1β, nuclear factor (NF)-κB, and mitogen-activated protein kinase (MAPK) signaling. This study aimed to investigate the effect of ceftiofur on hyperalgesia and allodynia in neuropathic rats and to define the possible contribution of immune mechanisms to this effect...
June 15, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28535535/inflammation-is-an-important-covariate-for-the-crosstalk-of-sleep-and-the-hpa-axis-in-rheumatoid-arthritis
#16
Rainer H Straub, Jaqueline Detert, René Dziurla, Ingo Fietze, Peter-Andreas Loeschmann, Gerd R Burmester, Frank Buttgereit
Rheumatoid arthritis (RA) patients have sleep problems, and inflammation influences sleep. We demonstrated that sleep quality improves during intensified treatment with methotrexate (MTX) or etanercept (ETA). Since the hypothalamic-pituitary-adrenal (HPA) axis is involved in sleep regulation, this study investigated the interrelation between sleep parameters, inflammation as objectified by C-reactive protein (CRP), and serum cortisol and adrenocorticotropic hormone (ACTH) levels. Thirty-one eligible patients (disease activity score, DAS28CRP ≥3...
May 24, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28478458/acute-lipopolysaccharide-switches-the-selection-of-maternal-behavior-to-predatory-behavior-in-female-rats
#17
Tiberiade Mendes-Lima, Thiago Berti Kirsten, Luciano Freitas Felicio, Elizabeth Teodorov, Nicolle Queiroz-Hazarbassanov, Maria Martha Bernardi
OBJECTIVES: A common problem during the postpartum period and during lactation is being affected by infection due to Gram-negative bacteria. In this situation, a sick mother needs to choose between caring for her pups or the need for survival. This study analyzed the effects of lipopolysaccharide (LPS)-induced sickness behavior on selection between maternal behavior (MB) and predatory behavior (PB) in lactating rats. To assess the LPS-induced sickness behavior, the plasma tumor necrosis factor-α (TNF-α) levels were measured...
May 6, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29514151/differential-response-of-dopamine-mediated-by-%C3%AE-adrenergic-receptors-in-human-keratinocytes-and-macrophages-potential-implication-in-wound-healing
#18
Andrea Cecilia Parrado, Luciana Soledad Salaverry, Franco Mauricio Mangone, Carolina Eugenia Apicella, Teresa Gentile, Andrea Canellada, Estela Beatriz Rey-Roldán
OBJECTIVE: Dopamine is an immunomodulatory neurotransmitter. In the skin, keratinocytes and macrophages produce proinflammatory cytokines and metalloproteinases (MMPs) which participate in wound healing. These cells have a catecholaminergic system that modulates skin pathophysiologic processes. We have demonstrated that dopamine modulates cytokine production in keratinocytes via dopaminergic and adrenergic receptors (ARs). The aim of this study was to evaluate the effect of dopamine and its interaction with β-ARs in human HaCaT keratinocytes and THP-1 macrophages...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29510394/cytokine-production-by-mononuclear-cells-from-patients-with-familial-infantile-bilateral-striatal-necrosis
#19
Esther Ganelin Cohen, Hanna Bessler, Meir Djaldetti, Rachel Straussberg
Prompted by findings suggesting immune instability in infantile bilateral striatal necrosis (IBSN), we evaluated levels of proinflammatory (tumor necrosis factor α, interleukin [IL]-1β, IL-6, interferon [IFN]γ) and anti-inflammatory (IL-10 and IL-1ra) cytokines produced by peripheral blood mononuclear cells (PBMC) from 6 children with IBSN and 11 age-matched controls. Compared to controls, non-stimulated PBMC from the IBSN group produced a significantly lower level of IL-1ra (by 38%; p < 0.001) and significantly lower levels of TNFα, IL-1β, and IFNγ (by 36% [p < 0...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29486471/tnfaip3-mrna-level-is-associated-with-psychological-anxiety-in-major-depressive-disorder
#20
Ruei-An Chen, Tiao-Lai Huang, Kai-Wei Huang, Yi-Yung Hung
BACKGROUND: Major depressive disorder has been shown to be associated with inflammation and the dysregulation of innate immune responses. Previously, we showed an inverse correlation between the severity of depression and level of TNFAIP3 mRNA expression. The present study further evaluated the association between TNFAIP3 mRNA expression level and symptoms of major depressive disorder (MDD) in 91 patients (20 men and 71 women). METHODS: The relationships between subscores on the 17-item Hamilton Depression Rating Scale (HAMD-17) and TNFAIP3 mRNA levels were assessed by multiple linear regression...
2017: Neuroimmunomodulation
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