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Neuroimmunomodulation

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https://www.readbyqxmd.com/read/30007965/chronic-sleep-restriction-impairs-the-antitumor-immune-response-in-mice
#1
Beatriz Helena Pizarro De Lorenzo, Ronni Rômulo Novaes E Brito, Thatiane Paslar Leal, Nycole Piqueira Garcia, Rafaela Miranda Martins Dos Santos, Anuska Marcelino Alvares-Saraiva, Elizabeth Cristina Perez Hurtado, Tânia Carolina Braga Dos Reis, Beatriz Duarte Palma
OBJECTIVES: Sleep regulates immune function reciprocally and can affect the parameters that are directly involved in the immune response. Sleep deprivation is considered to be a stress-causing factor and is associated with impaired immune activity. It causes increased glucocorticoid concentrations by activating the hypothalamic-pituitary-adrenal axis; this can lead to a series of disorders that are associated with the prolonged or increased secretion of these hormones. The aim of this study was to evaluate the effects of sleep restriction (SR) on the development of pulmonary experimental metastasis and the modulation of the tumor immune response...
July 13, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29920500/rankl-rank-opg-axis-is-deregulated-in-the-cerebrospinal-fluid-of-multiple-sclerosis-patients-at-clinical-onset
#2
Anton Glasnović, Maristela Stojić, Lidija Dežmalj, Ivana Tudorić-Đeno, Dominik Romić, Vjekoslav Jeleč, Anđelko Vrca, Vladimira Vuletić, Danka Grčević
OBJECTIVES: Our study focused on the RANKL (receptor activator of nuclear factor-κB ligand)/RANK/OPG (osteoprotegerin) axis and selected proinflammatory/immunoregulatory upstream mediators in the peripheral blood (PBL) and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. METHODS: PBL and CSF were collected from healthy controls (n = 35) and MS patients at the clinical onset of the disease (n = 33). In addition, PBL samples were obtained from relapse-remitting (RR)-MS patients (n = 30)...
June 19, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29920498/preventive-effect-of-mebicar-and-ginsenoside-rg1-on-neurobehavioral-and-immunological-disruptions-caused-by-intermittent-unpredictable-stress-in-mice
#3
Chang Yul Kim, Yeon Gyeong Kim, So Jung Sin, Hyojin Koo, Kicheol Cheon, Dongsoo Kim
OBJECTIVES: Ginsenoside Rg1 and mebicar have been reported to have broad efficacy spectrum, including anti-anxiety and anti-stress. These drugs have been used not only for treatment but also for the purpose of increasing resistance from disease. A specific aim of this study was to investigate whether mebicar or ginsenoside Rg1 can prevent physiological changes resulting from intermittent unpredictable stress (IUS). METHODS: Seven week-old Balb/cByJ mice were administered orally with mebicar (10 mg/kg) or ginsenoside Rg1 (10 mg/kg) starting from a week before they were exposed to IUS until the end of the experiment...
June 19, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29898456/antidepressants-improve-negative-regulation-of-toll-like-receptor-signaling-in-monocytes-from-patients-with-major-depression
#4
Yi-Yung Hung
OBJECTIVE: Changes in the brain's inflammatory status can lead to psychopathological responses, especially depression. Using animal models, recent studies have revealed that this pathology is due, in part, to innate immune responses of monocytes. METHODS: We focus on the involvement of Toll-like receptors (TLRs) and expression of genes encoding their negative regulators, SOCS1, TOLLIP, SIGIRR, MyD88s, NOD2, and TNFAIP3, in CD14+ monocytes from 34 patients with major depressive disorder (MDD) and 33 healthy controls before and after treatment with antidepressants...
June 13, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29895009/stability-of-cellular-immune-parameters-over-12-weeks-in-patients-with-major-depression-or-somatoform-disorder-and-in-healthy-controls
#5
Daniela Krause, Theresa M Stapf, Verena B Kirnich, Anika Hennings, Sabine Riemer, Agnieszka Chrobok, Daniel R Fries, Francisco Pedrosa Gil, Winfried Rief, Markus J Schwarz, Ralf Schmidmaier
OBJECTIVE: Cellular immune status in major depression (MD) patients differs from that in somatoform disorder (SFD) patients and healthy controls (HC). It is still questionable whether the patterns of immune parameters remain stable over time. Therefore, we studied lymphocyte and monocyte cell counts and neopterin levels in peripheral blood of MD and SFD patients and HC over 12 weeks and tested for correlations between biochemical and psychometric parameters. METHODS: Thirty-nine patients with MD, 27 with SFD, and 51 HC were recruited...
June 12, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29874677/short-term-hyperprolactinemia-reduces-the-expression-of-purinergic-p2x7-receptors-during-allergic-inflammatory-response-of-the-lungs
#6
Julieta E Ochoa-Amaya, Nicolle Queiroz-Hazarbassanov, Lilian B Namazu, Atilio S Calefi, Carla N Tobaruela, Rafael Margatho, João Palermo-Neto, Ana P Ligeiro de Oliveira, Luciano F Felicio
PURPOSE: We have previously shown that domperidone-induced short-term hyperprolactinemia reduces the lung's allergic inflammatory response in an ovalbumin antigenic challenge model. Since purinergic receptor P2X7R activity leads to proinflammatory cytokine release and is possibly related to the pathogenesis of allergic respiratory conditions, the present study was designed to investigate a possible involvement of purinergic and prolactin receptors in this phenomenon. METHODS: To induce hyperprolactinemia, domperidone was injected intraperitoneally in rats at a dose of 5...
June 6, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29874674/a-review-on-the-role-of-inflammation-in-attention-deficit-hyperactivity-disorder
#7
Douglas Teixeira Leffa, Iraci L S Torres, Luis Augusto Rohde
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition that impairs quality of life in social, academic, and occupational contexts for both children and adults. Although a strong neurobiological basis has been demonstrated, the pathophysiology of ADHD is still poorly understood. Among the proposed mechanisms are glial activation, neuronal damage and degeneration, increased oxidative stress, reduced neurotrophic support, altered neurotransmitter metabolism, and blood-brain barrier disruption...
June 6, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29788018/brain-immunohistopathology-in-a-patient-with-autoimmune-glial-fibrillary-acidic-protein-astrocytopathy
#8
Yaqing Shu, Youming Long, Yanyu Chang, Rui Li, Xiaobo Sun, Yuge Wang, Yinong Huang, Jing Li, Jianning Chen, Yu Yang, Zhengqi Lu, Xueqiang Hu, Allan G Kermode, Wei Qiu
BACKGROUND: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel meningoencephalomyelitis. However, the pathogenesis of this disease is unclear. We therefore examined a brain biopsy from a patient with autoimmune GFAP astrocytopathy by immunohistopathology. METHODS: We examined brain biopsy sections from a patient with autoimmune GFAP astrocytopathy using hematoxylin and eosin (HE) and Luxol fast blue (LFB) staining, and immunostaining with antibodies for CD4, CD8, CD3, CD20, CD68, CD138, Neu-N, GFAP, myelin oligodendrocyte glycoprotein (MOG), and aquaporin-4 (AQP4)...
May 22, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29680839/decreased-migration-of-dendritic-cells-into-the-jugular-nodose-ganglia-by-the-cxcl12-neutraligand-chalcone-4-in-ovalbumin-sensitized-asthmatic-mice
#9
Sebastian Heck, François Daubeuf, Duc Dung Le, Martina Sester, Dominique Bonnet, Robert Bals, Nelly Frossard, Quoc Thai Dinh
OBJECTIVE: The chemokine CXCL12 interacting with the CXC receptor 4 (CXCR4) has been reported to play a role in the development and progression of bronchial asthma, but its mechanism of action is still unknown. The objective of this study was to assess the effect of the CXCL12 neutraligand chalcone 4 on the migration of dendritic cells (DCs) in a murine model of allergic airway inflammation. METHODS: A 21-day ovalbumin (OVA)-induced allergic-airway TH2 inflammation model in BALB/c mice was used...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29669346/tetrahydrocurcumin-provides-neuroprotection-in-experimental-traumatic-brain-injury-and-the-nrf2-signaling-pathway-as-a-potential-mechanism
#10
Guan Wei, Bingji Chen, Qingjiang Lin, Yasong Li, Liangqin Luo, Hefan He, Huangde Fu
The protective effect of tetrahydrocurcumin (THC) after experimental traumatic brain injury (TBI) has been demonstrated, as demonstrated by the inhibition of oxidative stress, mitochondrial dysfunction, and apoptosis. However, the mechanisms underlying this effect are still not well understood. This study was to investigate the neuroprotective effects of THC, and its potential mechanisms, in a rat model of TBI. To this end, rats were divided into 4 groups: the sham group, the TBI group, the TBI + vehicle (V) group, and the TBI + THC group...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29621768/protective-role-of-the-hepatic-vagus-nerve-against-liver-metastasis-in-mice
#11
Tetsuya Hiramoto, Kazufumi Yoshihara, Yasunari Asano, Nobuyuki Sudo
OBJECTIVE(S): Although accumulating evidence has shown that the autonomic nervous system is involved in liver pathology, its role in regulating cancer development remains unclear. The purpose of this study was to elucidate its detailed mechanisms. METHODS: A mouse model of liver metastasis of colorectal cancer was used. To elucidate the potential mechanisms involved, we examined the effect of selective hepatic vagotomy on the survival rate and liver-to-body weight...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29617700/vasoactive-intestinal-peptide-protects-salivary-glands-against-structural-injury-and-secretory-dysfunction-via-il-17a-and-aqp5-regulation-in-a-model-of-sj%C3%A3-gren-syndrome
#12
Chengyin Li, Fenglin Zhu, Bin Wu, Yue Wang
OBJECTIVE: Sjögren syndrome (SS) is an autoimmune disease involving exocrine glands. Currently, drugs that can improve both abnormal immunity and exocrine gland function are needed. The study aimed to investigate the effect and mechanism of vasoactive intestinal peptide (VIP) on the immune response and exocrine gland function in SS. METHODS: We investigated the effects of VIP on the immune response and secretory function of submandibular glands using NOD mice, and analyzed the expression of IL-17A and AQP5 (aquaporin 5)...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29597198/exercise-induced-change-in-plasma-il-12p70-is-linked-to-migraine-prevention-and-anxiolytic-effects-in-treatment-na%C3%A3-ve-women-a-randomized-controlled-trial
#13
Arão Belitardo Oliveira, Andre Luis Lacerda Bachi, Reinaldo Teixeira Ribeiro, Marco Túlio Mello, Mauro Vaisberg, Mario Fernando Prieto Peres
OBJECTIVE: To conduct a randomized controlled trial to evaluate the effect of a 12-week aerobic exercise program for migraine prevention, plasma cytokines concentrations (TNF-α, interleukin [IL]-1β, IL-6, IL-8, IL-10, and IL-12p70), and anxiety in women with migraine. METHODS: Women with episodic migraine (ICHD-II), aged between 20 and 50 years, who had never taken any prophylactic medication, and were physically inactive in the past 12 months were recruited from the university's hospital and a tertiary headache clinic between March 2012 and March 2015...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29558759/vitamin-b12-in-association-with-antipsychotic-drugs-can-modulate-the-expression-of-pro-anti-inflammatory-cytokines-in-alzheimer-disease-patients
#14
Alireza Vakilian, Seyed Moein Razavi-Nasab, Ali Ravari, Tayebeh Mirzaei, Amir Moghadam-Ahmadi, Nazanin Jalali, Reza Bahramabadi, Mohammadtaghi Rezayati, Amin Yazdanpanah-Ravari, Farhad Bahmaniar, Mohammad Reza Bagheri, Mahmood Sheikh Fathollahi, Gholamreza Asadikaram, Mohammad Kazemi Arababadi
INTRODUCTION: Patients with Alzheimer disease (AD) suffer from psychotic symptoms including pain. The current antipsychotic drugs confer limited effectiveness, and hence new strategies are being designed to decrease pain in order to increase antipsychological effectiveness. Vitamin B12 is a safe supplementary drug to decrease pain. Additionally, cytokines participate in the pathogenesis of immune-related diseases such as AD. Thus, the main aim of this clinical trial study was to determine the effects of treatment with risperidone and quetiapine, as antipsychotic drugs, with and without vitamin B12 on the psychotic symptoms of AD patients and the expression of IL-6, IL-8, tumor growth factor (TGF)-β, tumor necrosis factor (TNF)-α, and endothelin (ET)-1)...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29539621/immune-cell-neurotrophin-production-is-associated-with-subcortical-brain-atrophy-in-neuropsychiatric-systemic-lupus-erythematosus-patients
#15
Alicja Kalinowska-Łyszczarz, Mikołaj A Pawlak, Aleksandra Wyciszkiewicz, Katarzyna Pawlak-Buś, Piotr Leszczyński, Mariusz Puszczewicz, Włodzimierz Paprzycki, Wojciech Kozubski, Sławomir Michalak
OBJECTIVE: Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) remains poorly understood. Damage within the CNS is driven by the autoimmune response; however, immunopathophysiology of neuropsychiatric (NP) SLE is multifactorial. Immune cell neurotrophin production could be neuroprotective against autoimmunity-driven CNS damage, as has been shown in multiple sclerosis. The aim of this study was to establish whether immune cell neurotrophin production is associated with damage severity in NPSLE...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29514151/differential-response-of-dopamine-mediated-by-%C3%AE-adrenergic-receptors-in-human-keratinocytes-and-macrophages-potential-implication-in-wound-healing
#16
Andrea Cecilia Parrado, Luciana Soledad Salaverry, Franco Mauricio Mangone, Carolina Eugenia Apicella, Teresa Gentile, Andrea Canellada, Estela Beatriz Rey-Roldán
OBJECTIVE: Dopamine is an immunomodulatory neurotransmitter. In the skin, keratinocytes and macrophages produce proinflammatory cytokines and metalloproteinases (MMPs) which participate in wound healing. These cells have a catecholaminergic system that modulates skin pathophysiologic processes. We have demonstrated that dopamine modulates cytokine production in keratinocytes via dopaminergic and adrenergic receptors (ARs). The aim of this study was to evaluate the effect of dopamine and its interaction with β-ARs in human HaCaT keratinocytes and THP-1 macrophages...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29510394/cytokine-production-by-mononuclear-cells-from-patients-with-familial-infantile-bilateral-striatal-necrosis
#17
Esther Ganelin Cohen, Hanna Bessler, Meir Djaldetti, Rachel Straussberg
Prompted by findings suggesting immune instability in infantile bilateral striatal necrosis (IBSN), we evaluated levels of proinflammatory (tumor necrosis factor α, interleukin [IL]-1β, IL-6, interferon [IFN]γ) and anti-inflammatory (IL-10 and IL-1ra) cytokines produced by peripheral blood mononuclear cells (PBMC) from 6 children with IBSN and 11 age-matched controls. Compared to controls, non-stimulated PBMC from the IBSN group produced a significantly lower level of IL-1ra (by 38%; p < 0.001) and significantly lower levels of TNFα, IL-1β, and IFNγ (by 36% [p < 0...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29486471/tnfaip3-mrna-level-is-associated-with-psychological-anxiety-in-major-depressive-disorder
#18
Ruei-An Chen, Tiao-Lai Huang, Kai-Wei Huang, Yi-Yung Hung
BACKGROUND: Major depressive disorder has been shown to be associated with inflammation and the dysregulation of innate immune responses. Previously, we showed an inverse correlation between the severity of depression and level of TNFAIP3 mRNA expression. The present study further evaluated the association between TNFAIP3 mRNA expression level and symptoms of major depressive disorder (MDD) in 91 patients (20 men and 71 women). METHODS: The relationships between subscores on the 17-item Hamilton Depression Rating Scale (HAMD-17) and TNFAIP3 mRNA levels were assessed by multiple linear regression...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29414833/increased-proportion-of-tc17-and-th17-cells-and-their-significant-reduction-after-thymectomy-may-be-related-to-disease-progression-in-myasthenia-gravis
#19
Mina Hosseini, Behrouz Robat-Jazi, Vahid Shaygannejad, Shahriar Naffisi, Omid Mirmossayeb, Abbas Rezaei, Marjan Mansourian, Nafiseh Esmaeil
OBJECTIVE: Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies against the neuromuscular junction. The thymus has an important role in the pathogenesis of MG because most patients have thymic pathology, and thymectomy (TE) can reduce the severity of the disease. METHODS: In this study, the frequency of Th17 and Tc17 cells was studied in 12 MG patients (pre-TE and 6 months post-TE) and in 12 healthy controls (HC). RESULTS: The frequency of Tc17 cells in the pre-TE patients was significantly higher than in the HC (p < 0...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29393234/lipid-metabolism-in-patients-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#20
Yaqing Shu, Bing Qin, Yue Xu, Xiaobo Sun, Zheng Chen, Jia Wang, Lisheng Peng, Wei Qiu, Zhengqi Lu, Aimin Wu
OBJECTIVE: Lipid metabolism has been implicated in autoimmune disorders, but its relationship with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unclear. This study examined the association of serum lipids with anti-NMDAR encephalitis. METHODS: Serum lipid profiles and C-reactive protein (CRP) were evaluated in 68 patients with anti-NMDAR encephalitis, and 68 age- and sex-matched healthy controls (CTLs). Follow-up evaluations were conducted 3 months after admission in 32 of the 68 patients...
2017: Neuroimmunomodulation
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