Read by QxMD icon Read


Monika Pal, Santhosh Kumar, Muralidhar Varma, Pratibha Gopalkrishna, Subraya Bhat
BACKGROUND AND OBJECTIVES: The purpose of this study was to assess pyrexia and sickness behavior such as anxiety, depression, lethargy, and weight loss in subjects with chronic periodontitis, and evaluate inflammatory mediators such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in the patients with fever. METHODS: This was a cross-sectional study that consisted of 150 chronic periodontitis and 150 healthy subjects. Sublingual and subgingival temperatures were assessed using a digital temperature probe...
September 10, 2018: Neuroimmunomodulation
Josemar Marchezan, Eduardo Geyer Arrussul Winkler Dos Santos, Iohanna Deckmann, Rudimar Dos Santos Riesgo
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with an unknown etiology and currently few effective therapies. Immune system alterations have being demonstrated in ASD, both in humans and via animal models; immune imbalance thus arises as a possible pathway for drug intervention. In this review, the studies were classified into 2 major groups: (1) clinical research whose authors classify therapies with primary anti-inflammatory and immunomodulatory actions, making use of: sulforaphane, celecoxib, lenalidomide, pentoxifylline, spironolactone, flavonoid luteolin, corticosteroids, oral immunoglobulin, intravenous immunoglobulin, cell therapy, dialyzable lymphocyte extracts, minocycline, and pioglitazone; and (2) other ASD therapies already used or currently under study whose initial characteristics were neither anti-inflammatory nor immunomodulatory initially, but displayed a capacity for immunomodulation throughout the treatment: risperidone, vitamin D, omega-3, Ginkgo biloba, L-carnosine, N-acetylcysteine, and microbiome restoration...
September 5, 2018: Neuroimmunomodulation
Iohanna Deckmann, Gustavo Brum Schwingel, Mellanie Fontes-Dutra, Victorio Bambini-Junior, Carmem Gottfried
Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized by deficits in communication and social interaction and in stereotyped or repetitive behaviors. Besides the classical behavioral dyad, several comorbidities are frequently present in patients with ASD, such as anxiety, epilepsy, sleep disturbances, and gastrointestinal tract dysfunction. Although the etiology of ASD remains unclear, there is supporting evidence for the involvement of both genetic and environmental factors...
August 29, 2018: Neuroimmunomodulation
Renata Torres Abib, Alexandru Gaman, Aroldo A Dargél, Ryad Tamouza, Flávio Kapczinski, Carmem Gottfried, Marion Leboyer
BACKGROUND/AIMS: Perinatal exposure to infections during critical developmental periods is a promising area of study in autism spectrum disorder (ASD). Epidemiological data has highlighted this relationship, pointing out significant correlations between perinatal exposure to pathogens and the occurrence of ASD. The aim of this review is to critically examine the present state of the art on intracellular pathogenic infection during pregnancy and postnatally, pointing out possible correlations with the development of ASD...
August 21, 2018: Neuroimmunomodulation
Diego Baronio, Guilherme Bauer-Negrini, Kamila Castro, Gustavo Della-Flora Nunes, Rudimar Riesgo, Daniella Arêas Mendes-da-Cruz, Wilson Savino, Carmem Gottfried, Victorio Bambini-Junior
Considering the potential role of lymphocytes in the pathophysiology of autism spectrum disorder (ASD), we aimed to evaluate possible alterations of T cell pools in the lymphoid organs of an animal model of autism induced by valproic acid (VPA). Pregnant Swiss mice received a single intraperitoneal injection of 600 mg/kg of VPA (VPA group) or saline (control group) on day 11 of gestation. Male offspring were euthanized on postnatal day 60 for removal of thy-muses, spleens, and a pool of inguinal, axillary and brachial lymph nodes...
August 17, 2018: Neuroimmunomodulation
Douglas Teixeira Leffa, Iraci L S Torres, Luis Augusto Rohde
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition that impairs quality of life in social, academic, and occupational contexts for both children and adults. Although a strong neurobiological basis has been demonstrated, the pathophysiology of ADHD is still poorly understood. Among the proposed mechanisms are glial activation, neuronal damage and degeneration, increased oxidative stress, reduced neurotrophic support, altered neurotransmitter metabolism, and blood-brain barrier disruption...
June 6, 2018: Neuroimmunomodulation
Xiaoyu Ma, Qingqing Yin, Ziling Zeng, Chunjuan Wang, Yang Yang, Shougang Guo
OBJECTIVE: Previous studies have shown that functional abnormalities of the thyroid are associated with the pathogenesis of several neurological diseases. However, their relationship in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis remains to be defined. METHODS: Forty-three patients with anti-NMDAR encephalitis were examined for thyroid function and autoimmune indications, in comparison with 225 healthy controls (CTL). Patients were further classified into 2 subgroups based on their free tri-iodothyronine (fT3) levels...
2018: Neuroimmunomodulation
Amanda Fiorentina Nascimento, Shelley Kirychuk, Maria Martha Bernardi, Luciano F Felício
OBJECTIVES: Previous studies from our group showed that lipopolysaccharide (LPS) exposure induces several signs of sickness behavior, including a decrease in food consumption, body weight gain, adipsia, and a biphasic effect in tympanic temperature with a first phase of hypothermia, followed by an increased tympanic temperature. LPS can activate a chain of nonspecific host responses, including the immune response, and decreased zinc levels. In addition, there are differences in the immune response between males and females, particularly fever, with sex hormones interfering with body temperature...
2018: Neuroimmunomodulation
Vanessa Gama Goulart, Grasielle Duarte Menezes, Sheila Espírito-Santo, Adriana da Cunha Faria-Melibeu, Claudio Alberto Serfaty, Paula Campello-Costa
OBJECTIVE: Interleukin 4 (IL-4) is an anti-inflammatory cytokine related to different aspects of central nervous system development such as survival, proliferation, and differentiation, among others. Our goals were to investigate the effect of intravitreous treatment with IL-4 on the activation of downstream signaling pathways in the retina and the distribution of retinal axons within the superior colliculus (SC). MATERIAL AND METHODS: Lister hooded rats were submitted to an intravitreous injection of either IL-4 (5 U/µL) or PBS (vehicle) at postnatal day 10 (PND10)...
2018: Neuroimmunomodulation
Behrouz Robat-Jazi, Mina Hosseini, Vahid Shaygannejad, Shahriar Nafissi, Abbas Rezaei, Marjan Mansourain, Omid Mirmosayyeb, Nafiseh Esmaeil
OBJECTIVES: Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis. METHODS: Twelve pre- and post-TE MG patients and 12 healthy controls (HCs) were enrolled. The mean percentages of Th22 and Tc22 cells were evaluated in MG patients (before and 6 months after TE) and HCs. RESULTS: The mean percentage of Tc22 cells in pre-TE patients was significantly higher than in HCs (p < 0...
2018: Neuroimmunomodulation
Zifan Liu, Qingmei Huang, Huijuan Li, Wei Qiu, Baikeng Chen, Jie Luo, Huacai Yang, Tianni Liu, Si Liu, Huiming Xu, Youming Long, Cong Gao
OBJECTIVE: The aim of this study was to evaluate the positive rate of serum glutamic acid decarboxylase (GAD) autoantibody in patients with myelitis and to describe the clinical findings in patients with positive GAD antibody. METHODS: Serum samples were collected from 390 patients with myelitis, including 210 patients positive for aquaporin 4 (AQP4) antibody and 180 patients negative for AQP4. GAD65 antibody was measured by an indirect immunofluorescence assay...
2018: Neuroimmunomodulation
Sunjung Park, Eun Jin Yang
OBJECTIVE: Chronic neuroinflammation after spinal cord injury (SCI) is associated with spinal cord damage and functional impairment. In patients, SCI is associated with severe disability, an extensive rehabilitation requirement, and high cost burden. Moreover, there is no effective treatment for SCI. Taklisodok-um (TLSDU) is a traditional herbal medicine used in Korea and China to facilitate detoxification and drainage. This study investigated the therapeutic effect of TLSDU after SCI...
2018: Neuroimmunomodulation
Asiel Arce-Sillas, Graciela Cárdenas, Diana Álvarez-Luquín, Marisela Hernandez, Adriana Del Rey, Hugo Besedovsky, Sandra Gómez-Fuentes, Gladis Fragoso, Agnes Fleury, Edda Sciutto, Laura Adalid-Peralta
OBJECTIVE: The aim of this study is to analyze the immune-endocrine profile in neurocysticercosis (NC) patients resistant to cysticidal treatment. METHODS: The inflammatory and regulatory responses of 8 resistant NC patients with extraparenchymal parasites and 5 healthy controls were evaluated through flow cytometry. Serum interleukin levels were measured by ELISA and catecholamines levels by high performance liquid chromatography. RESULTS: Higher percentages of Tr1, CD4+CD25+FOXP3+CD127- and CD4+CD45RO+FOXP3HI were found in NC patients compared with healthy controls, but no difference was found in catecholamine levels...
2018: Neuroimmunomodulation
Gisele Gomes de Andrade, Laura Reck Cechinel, Karine Bertoldi, Fernando Galvão, Paulo Valdeci Worm, Ionara Rodrigues Siqueira
OBJECTIVE(S): The aim of this study was to investigate exosomal markers and inflammatory cargo of extracellular vesicles (EVs) obtained from cerebrospinal fluid (CSF) and plasma in the aging process. We also studied the inflammatory cargo by quantifying IL-1β levels. METHODS: Male Wistar rats, aged 3 and 21 months, were used (n = 12 in each group). The CSF and plasma of animals were collected, and isolation of EVs was performed using a commercial kit. Total protein concentration, acetylcholinesterase (AChE) activity, and CD63 and IL-1β levels were evaluated...
2018: Neuroimmunomodulation
Beatriz Helena Pizarro De Lorenzo, Ronni Rômulo Novaes E Brito, Thatiane Paslar Leal, Nycole Piqueira Garcia, Rafaela Miranda Martins Dos Santos, Anuska Marcelino Alvares-Saraiva, Elizabeth Cristina Perez Hurtado, Tânia Carolina Braga Dos Reis, Beatriz Duarte Palma
OBJECTIVES: Sleep regulates immune function reciprocally and can affect the parameters that are directly involved in the immune response. Sleep deprivation is considered to be a stress-causing factor and is associated with impaired immune activity. It causes increased glucocorticoid concentrations by activating the hypothalamic-pituitary-adrenal axis; this can lead to a series of disorders that are associated with the prolonged or increased secretion of these hormones. The aim of this study was to evaluate the effects of sleep restriction (SR) on the development of pulmonary experimental metastasis and the modulation of the tumor immune response...
2018: Neuroimmunomodulation
Anton Glasnović, Maristela Stojić, Lidija Dežmalj, Ivana Tudorić-Đeno, Dominik Romić, Vjekoslav Jeleč, Anđelko Vrca, Vladimira Vuletić, Danka Grčević
OBJECTIVES: Our study focused on the RANKL (receptor activator of nuclear factor-κB ligand)/RANK/OPG (osteoprotegerin) axis and selected proinflammatory/immunoregulatory upstream mediators in the peripheral blood (PBL) and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. METHODS: PBL and CSF were collected from healthy controls (n = 35) and MS patients at the clinical onset of the disease (n = 33). In addition, PBL samples were obtained from relapse-remitting (RR)-MS patients (n = 30)...
2018: Neuroimmunomodulation
Chang Yul Kim, Yeon Gyeong Kim, So Jung Sin, Hyojin Koo, Kicheol Cheon, Dongsoo Kim
OBJECTIVES: Ginsenoside Rg1 and mebicar have been reported to have broad efficacy spectrum, including anti-anxiety and anti-stress. These drugs have been used not only for treatment but also for the purpose of increasing resistance from disease. A specific aim of this study was to investigate whether mebicar or ginsenoside Rg1 can prevent physiological changes resulting from intermittent unpredictable stress (IUS). METHODS: Seven week-old Balb/cByJ mice were administered orally with mebicar (10 mg/kg) or ginsenoside Rg1 (10 mg/kg) starting from a week before they were exposed to IUS until the end of the experiment...
2018: Neuroimmunomodulation
Yi-Yung Hung
OBJECTIVE: Changes in the brain's inflammatory status can lead to psychopathological responses, especially depression. Using animal models, recent studies have revealed that this pathology is due, in part, to innate immune responses of monocytes. METHODS: We focus on the involvement of Toll-like receptors (TLRs) and expression of genes encoding their negative regulators, SOCS1, TOLLIP, SIGIRR, MyD88s, NOD2, and TNFAIP3, in CD14+ monocytes from 34 patients with major depressive disorder (MDD) and 33 healthy controls before and after treatment with antidepressants...
2018: Neuroimmunomodulation
Daniela Krause, Theresa M Stapf, Verena B Kirnich, Anika Hennings, Sabine Riemer, Agnieszka Chrobok, Daniel R Fries, Francisco Pedrosa Gil, Winfried Rief, Markus J Schwarz, Ralf Schmidmaier
OBJECTIVE: Cellular immune status in major depression (MD) patients differs from that in somatoform disorder (SFD) patients and healthy controls (HC). It is still questionable whether the patterns of immune parameters remain stable over time. Therefore, we studied lymphocyte and monocyte cell counts and neopterin levels in peripheral blood of MD and SFD patients and HC over 12 weeks and tested for correlations between biochemical and psychometric parameters. METHODS: Thirty-nine patients with MD, 27 with SFD, and 51 HC were recruited...
2018: Neuroimmunomodulation
Julieta E Ochoa-Amaya, Nicolle Queiroz-Hazarbassanov, Lilian B Namazu, Atilio S Calefi, Carla N Tobaruela, Rafael Margatho, João Palermo-Neto, Ana P Ligeiro de Oliveira, Luciano F Felicio
PURPOSE: We have previously shown that domperidone-induced short-term hyperprolactinemia reduces the lung's allergic inflammatory response in an ovalbumin antigenic challenge model. Since purinergic receptor P2X7R activity leads to proinflammatory cytokine release and is possibly related to the pathogenesis of allergic respiratory conditions, the present study was designed to investigate a possible involvement of purinergic and prolactin receptors in this phenomenon. METHODS: To induce hyperprolactinemia, domperidone was injected intraperitoneally in rats at a dose of 5...
2018: Neuroimmunomodulation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"