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Neuroimmunomodulation

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https://www.readbyqxmd.com/read/27902989/plasma-levels-of-leptin-and-adiponectin-in-fragile-x-syndrome
#1
Małgorzata Zofia Lisik, Ewa Gutmajster, Aleksander L Sieroń
: Fragile X syndrome (FXS) is the most common form of familial mental retardation and one of the leading known causes of autism. The mutation responsible for FXS is a large expansion of the CGG repeats in the promoter region of the FMR1 gene, resulting in the transcriptional silencing of the gene. Leptin may be considered a cytokine-like hormone with pleiotropic actions since it may be involved in the regulation of neuroendocrine functions and the immune system response, in addition to playing a role in development...
December 1, 2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27894110/significant-role-s-of-cxcl12-and-the-sdf-1-3-a-genetic-variant-in-the-pathogenesis-of-multiple-sclerosis
#2
Mojgan Noroozi Karimabad, Soudeh Khanamani Falahati-Pour, Gholamhossein Hassanshahi
Both cellular and molecular components of the immune system are among the substantial factors involved in the pathogenesis of multiple sclerosis (MS). Accumulating evidence confirms that chemokines, as the main members of the immune system, play key roles in the regulation of immune responses. Immune system genetic parameters are believed to influence the onset of immune system-related diseases. Regarding the significant role of the CXCR4/CXCL12 axis in cell differentiation and survival and homing of hematopoietic progenitors to the bone marrow and regulation of neuronal progenitor cell migration in the central nervous system (CNS), genetic factors can cause an increased expression of CXCL12 and induce a vigorous immune response against CNS antigens in MS patients...
November 29, 2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27846628/minocycline-suppresses-nlrp3-inflammasome-activation-in-experimental-ischemic-stroke
#3
Yunnan Lu, Guodong Xiao, Weifeng Luo
OBJECTIVE: Minocycline, a tetracycline antibiotic, has shown anti-inflammatory effects in cerebral ischemia and neurodegenerative disease; however, the molecular mechanisms underlying this effect have not been clearly identified. Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1β (IL-1β) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation...
November 16, 2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27820940/activated-phosphorylated-stat1-levels-as-a-biologically-relevant-immune-signal-in-schizophrenia
#4
Rajiv P Sharma, Cherise Rosen, Jennifer K Melbourne, Benjamin Feiner, Kayla A Chase
OBJECTIVE: Activation of STAT1 is directly downstream of the cytokine receptors that signal from specific proinflammatory cytokines known to be dysregulated in schizophrenia (SZ), such as IFNγ, IL6, IL2 and IL10, as well as hypoxia, viral/bacterial infections and peptide growth factors. If the increased cytokine protein levels repeatedly observed in SZ have biological consequences, then the measurement of pSTAT1 is a logical step forward. METHODS: Peripheral blood mononuclear cells (PBMCs) from controls (n = 13) and subjects with SZ (n = 22) were extracted using the Ficoll method...
November 8, 2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27771719/toll-like-receptor-3-contributes-to-wallerian-degeneration-after-peripheral-nerve-injury
#5
Hyunkyoung Lee, Jiyeon Baek, Hyunjung Min, Ik-Hyun Cho, Seong-Woo Yu, Sung Joong Lee
OBJECTIVE: It is well known that Schwann cells play an important role in Wallerian degeneration after peripheral nerve injury. Previously, we reported that toll-like receptor 3 (TLR3) is expressed on Schwann cells, implicating its role in Schwann cell activation during Wallerian degeneration. In this study, we tested this possibility using TLR3 knock-out mice. METHODS: Sciatic nerve-crush injury was induced in wild-type and TLR3 knock-out mice. Histological sections of the sciatic nerve were analyzed for Wallerian degeneration on days 3 and 7 after injury...
October 22, 2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27710965/the-role-of-biogenic-amines-in-the-regulation-of-interaction-between-the-immune-and-nervous-systems-in-multiple-sclerosis
#6
Alexey Boyko, Mikhail Melnikov, Rustam Zhetishev, Mikhail Pashenkov
OBJECTIVE: Multiple sclerosis (MS) is a demyelinating, presumably autoimmune disease of the central nervous system. Biogenic amines may participate in MS pathogenesis modulating immune cell activity and cytokine production. METHODS: Forty-three patients with relapsing-remitting MS were examined. Serotonin (SE), norepinephrine (NE) and epinephrine (EPI) concentrations in sera were measured by ELISA. The functional activity of Th17 and Th1 cells was assessed by the ability of peripheral blood mononuclear cells (PBMCs) to produce interferon-gamma (IFN-γ) and interleukin-17 (IL-17) and cell proliferation upon stimulation with microbeads coated with anti-CD3 and anti-CD28 antibodies...
October 7, 2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27842309/dr-james-matthew-lipton-1938-2016
#7
(no author information available yet)
No abstract text is available yet for this article.
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27780170/curcumin-diferulolylmethane-reduces-transglutaminase-2-overexpression-induced-by-retinoic-acid-in-human-nervous-cell-lines
#8
Nicola Gaetano Gatta, Gaetano Cammarota, Martina Iannaccone, Enrica Serretiello, Vittorio Gentile
OBJECTIVES: Curcumin, a naturally occurring compound derived from turmeric (Curcuma longa) has long been suggested to have strong therapeutic or preventive potential against human diseases because of its antioxidative, anticancerous, and anti-inflammatory effects. Curcumin is known to exert anti-inflammatory effects by interrupting NF-κB signaling at multiple levels. Many observations indicate that curcumin shows its valuable potential by inhibiting the activity of I-κB kinase. Transglutaminase 2 (TG2) expression is increased in inflammatory diseases...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27764833/effects-of-the-sympathetic-nervous-system-on-regulatory-t-cell-and-t-helper-1-chemokine-expression-in-patients-with-acute-coronary-syndrome
#9
Xiuqing Tian, Rui Guo, Yujiao Zhang, Lingling Xu, Xianbing Liu, Yinglong Hou
OBJECTIVE: To observe the effects of sympathetic overactivity on the immune system involved in the imbalance of T helper (Th) lymphocytes, we investigated the correlation between autonomic dysregulation and the generation of regulatory T (Treg) and Th1 chemokines in patients with acute coronary syndrome (ACS). METHODS: Blood samples obtained from patients with coronary artery disease and controls were analyzed for levels of Th1 and Treg cells and their associated cytokines by flow cytometry...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27644033/rutin-acid-ameliorates-neural-apoptosis-induced-by-traumatic-brain-injury-via-mitochondrial-pathways-in-mice
#10
Xiaofu Zhai, Ying Ding, Qi Wang, Hao Zhang, Fayin Li
Rutin reportedly conveys many beneficial effects, including neuroprotection in brain injury. However, the mechanisms underlying these effects are still not well understood. This study investigates the effect of rutin on potential mechanisms for neuroprotective effects, using the weight-drop model of traumatic brain injury (TBI) in male mice treated either with rutin or a vehicle via intraperitoneal injection 30 min after TBI. After euthanasia and 24 h after TBI, all mice were examined by tests, including neurologic scores, blood-brain barrier permeability, brain water content and neuronal cell death in the cerebral cortex...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27606627/immunological-profile-in-individuals-with-schistosomal-myeloradiculopathy
#11
Ramon de Almeida Kruschewsky, Luciana Santos Cardoso, Jamille Souza Fernandes, Robson da Paixão de Souza, Diego Mota Lopes, Otavio Augusto Moreno de Carvalho, Maria Ilma Araujo
BACKGROUND: Schistosomal myeloradiculopathy (SMR) is the most serious ectopic presentation of Schistosoma mansoni infection. The pathogenesis occurs mainly via the host inflammatory response to the eggs of the parasite that are stuck in the central nervous system, and the diagnosis is generally made by the exclusion of other neurological diseases. OBJECTIVE: We aimed to evaluate the immune status of SMR patients and to identify a marker for SMR diagnosis. METHODS: We enrolled 15 patients with a presumptive diagnosis of SMR, and the control groups included 17 patients with myelopathy associated with human T cell lymphotropic virus type 1 (HTLV-1) and 11 with other neurological disorders...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27603214/multiple-autoantibodies-and-neuromyelitis-optica-spectrum-disorders
#12
Chen Chen, Sun Xiaobo, Wang Yuge, Shu Yaqing, Fang Ling, Peng Lisheng, Lu Zhengqi, Qiu Wei
OBJECTIVE: To investigate the relationship between neuromyelitis optica spectrum disorder (NMOSD) and autoantibodies. METHODS: Blood samples of 108 NMOSD patients and 38 controls were collected from January 2012 to August 2014. Immunological parameters, including anti-aquaporin 4, antinuclear, anti-ribonucleoprotein, anti-SM, anti-SSA/Ro, anti-SSB/La and anti-ribosomal P-protein autoantibodies were examined. RESULTS: The NMOSD group exhibited a significantly higher percentage of anti-aquaporin 4 antibodies compared with the control group (76...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27529430/exaggerated-increases-in-microglia-proliferation-brain-inflammatory-response-and-sickness-behaviour-upon-lipopolysaccharide-stimulation-in-non-obese-diabetic-mice
#13
Barry McGuiness, Sinead M Gibney, Wouter Beumer, Marjan A Versnel, Inge Sillaber, Andrew Harkin, Hemmo A Drexhage
: The non-obese diabetic (NOD) mouse, an established model for autoimmune diabetes, shows an exaggerated reaction of pancreas macrophages to inflammatory stimuli. NOD mice also display anxiety when immune-stimulated. Chronic mild brain inflammation and a pro-inflammatory microglial activation is critical in psychiatric behaviour. OBJECTIVE: To explore brain/microglial activation and behaviour in NOD mice at steady state and after systemic lipopolysaccharide (LPS) injection...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27287756/the-possible-role-of-toll-like-receptor-4-in-the-pathology-of-stroke
#14
Elham Hakimizadeh, Mohammad Kazemi Arababadi, Ali Shamsizadeh, Ali Roohbakhsh, Mohammad Allahtavakoli
Stroke is a prevalent and dangerous health problem, which triggers an intense inflammatory response to Toll-like receptor (TLR) activation. TLRs are the essential components of the response of the innate immunity system, and, therefore, they are one of the key factors involved in recognizing pathogens and internal ligands. Among TLRs, TLR4 significantly participates in the induction of inflammation and brain functions; hence, it has been hypothesized that this molecule is associated with several immune-related brain diseases such as stroke...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27216735/effects-of-hyperbaric-oxygen-therapy-on-inflammasome-signaling-after-traumatic-brain-injury
#15
Fengyang Geng, Yinghua Ma, Tao Xing, Xianbo Zhuang, Jianxin Zhu, Lusu Yao
OBJECTIVE: Neuroinflammation plays an important role in secondary tissue damage after traumatic brain injury (TBI). Recently, the inflammasome-mediated inflammatory pathway has been observed in the inflammatory response of TBI. In this study, we investigated the influence of hyperbaric oxygen therapy (HBOT) on inflammasome activation after TBI. METHODS: The experimental mice were randomly divided into 4 groups as follows: sham-operated normobaric air (21% O2 at one absolute atmosphere), HBOT only, TBI + normobaric air and TBI + HBOT...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27088850/a-helminth-protease-inhibitor-modulates-the-lipopolysaccharide-induced-proinflammatory-phenotype-of-microglia-in-vitro
#16
Peter Behrendt, Philipp Arnold, Max Brueck, Uta Rickert, Richard Lucius, Susanne Hartmann, Christian Klotz, Ralph Lucius
OBJECTIVE: The aim of this study was to examine whether the natural protease inhibitor Av-cystatin (rAv17) of the parasitic nematode Acanthocheilonema viteae exerts anti-inflammatory effects in an in vitro model of lipopolysaccharide (LPS)-activated microglia. METHODS: Primary microglia were harvested from the brains of 2-day-old Wistar rats and cultured with or without rAv17 (250 nM). After 6 and 24 h the release of nitric oxide (Griess reagent) and TNF-α (ELISA) was measured in the supernatant...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27064690/isotetrandrine-reduces-astrocyte-cytotoxicity-in-neuromyelitis-optica-by-blocking-the-binding-of-nmo-igg-to-aquaporin-4
#17
Meiyan Sun, Jie Wang, Yue Zhou, Zijian Wang, Yong Jiang, Miao Li
OBJECTIVE: Neuromyelitis optica (NMO) is a severe neurological demyelinating autoimmune disease that affects the optic nerves and spinal cord with no cure and no FDA-approved therapy. Research over the last decade revealed that the binding of NMO-IgG to the water channel protein astrocyte aquaporin 4 (AQP4) might be the primary cause of NMO pathogenesis. The purpose of this study was to identify potential blockers of NMO-IgG and AQP4 binding. METHODS: We developed a two-step screening platform consisting of a reporter cell-based high-throughput screen assay and a cell viability-based assay...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27035148/a-follow-up-study-of-50-chronic-hepatitis-c-patients-adiponectin-as-a-resilience-biomarker-for-major-depression
#18
Bruno C Fábregas, Érica L M Vieira, Alexandre S Moura, Ricardo A Carmo, Renata E Ávila, Mery N S Abreu, Allan R Prossin, Antônio L Teixeira
OBJECTIVE: Major depression (MD) is a condition associated with both hepatitis C virus (HCV) infection and pegylated interferon (IFN)-α treatment. IFN induces a depressive syndrome that is associated with an inflammatory profile. We aimed to investigate whether there is any specific alteration in plasma biomarkers associated with MD. METHODS: HCV-monoinfected patients, with and without IFN treatment, were followed up for 18 months and went through structured psychiatric evaluation...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27031648/intravitreous-injection-of-interleukin-6-leads-to-a-sprouting-in-the-retinotectal-pathway-at-different-stages-of-development
#19
Grasielle D Menezes, Vanessa G Goulart, Sheila Espírito-Santo, Priscilla Oliveira-Silva, Claudio Alberto Serfaty, Paula Campello-Costa
OBJECTIVE: The development of retinotectal pathways form precise topographical maps is usually completed by the third postnatal week. Cytokines participate in the development and plasticity of the nervous system. We have previously shown that in vivo treatment with interleukin 2 disrupts the retinocollicular topographical order in early stages of development. Therefore, we decided to study the effect of a single intravitreous injection of IL-6 upon retinotectal circuitry in neonates and juvenile rats...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/26999663/1-25-dihydroxyvitamin-d3-facilitates-m2-polarization-and-upregulates-tlr10-expression-on-human-microglial-cells
#20
Rewa Verma, Jae Young Kim
OBJECTIVE: To explore the effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D, on M1/M2 polarization of human microglia and the expression of Toll-like receptor 10 (TLR10) on these cells, which has been suggested to play an inhibitory role in inflammation previously. METHODS: Microglial HMO6 cells were treated with 1,25(OH)2D3, and mRNA or protein levels of M1 and M2 cytokines and TLR10 were examined. RESULTS: 1,25(OH)2D3 upregulated TLR10 in HMO6 cells at both mRNA and protein level...
2016: Neuroimmunomodulation
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