Chen Chang, Yi-Lin Chen, Yi-Wen Wang, Hui-Wen Chen, Che-Wei Hsu, Kun-Che Lin, Yin-Chien Ou, Tsunglin Liu, Wan-Li Chen, Chien-An Chu, Chung-Liang Ho, Chung-Ta Lee, Nan-Haw Chow
Various types of human cancer may develop aberrant trophoblastic differentiation, including histological changes and altered expression of β‑human chorionic gonadotropin (β‑hCG). Aberrant trophoblastic differentiation in epithelial cancer is usually associated with poor differentiation, tumor metastasis, unfavorable prognosis and treatment resistance. Since β‑hCG‑targeting vaccines have failed in an early phase II trial, it is crucial to obtain a better understanding of the molecular pathogenesis of trophoblastic differentiation in human cancer...
March 2024: Oncology Reports