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Oncology Reports

Yuqin Pan, Huiling Sun, Xiuxiu Hu, Bangshun He, Xiangxiang Liu, Tao Xu, Xiaoxiang Chen, Kaixuan Zeng, Shukui Wang
Recently, miR‑485‑5p was identified as a tumor‑suppressing microRNA in some human cancers. However, the expression and biological role of miR‑485‑5p in colorectal cancer (CRC) remain unclear. Herein, we found that the expression of miR‑485‑5p in CRC tissues and cell lines was much lower than that in the control, respectively. Moreover, the overexpression of miR‑485‑5p could inhibit the proliferation and invasion of CRC cell lines in vitro and in vivo. Furthermore, we determined that miR‑485‑5p could decrease the expression of CD147 by directly targeting CD147 3'UTR...
March 12, 2018: Oncology Reports
Qiwei Chen, Liang Zhu, Huafeng Zong, Xishuang Song, Lina Wang, Xuejian Wang, Deyong Yang, Jianbo Wang
We previously found that in normal epithelia of the prostate, localization of AQP3 is limited to the cell membranes; however, the expression of AQP3 protein in cancer epithelia is distributed to the plasma. Yet, the detailed mechanism remains unclear. In the present study, PC‑3 cell derivatives with stable knockdown of RAS like proto‑oncogene A (RalA) and overexpression of E‑cadherin were established. We found that overexpression of E‑cadherin and knockdown of RaLA resulted in an increase in AQP3 in prostate cancer cell plasma membranes...
March 9, 2018: Oncology Reports
P Fallahi, R Foddis, G Elia, F Ragusa, A Patrizio, S Benvenga, A Cristaudo, A Antonelli, S M Ferrari
Vanadium is a grey metal, existing in different states of oxidation, whose most common form in commercial products is vanadium pentoxide (V2O5). All vanadium compounds have been considered toxic. A carcinogenic role of vanadium on the thyroid has recently been proposed. However no in vivo or in vitro studies have evaluated thyroid disruption in humans and/or animals after exposure to vanadium. In the present study we evaluate the effect of V2O5 on proliferation, and chemokine secretion in normal thyrocytes...
March 8, 2018: Oncology Reports
Hong Luo, Jin Quan, He Xiao, Jia Luo, Qin Zhang, Guocheng Pi, Yunfei Ye, Rong He, Yun Liu, Xiaona Su, Lianhua Zhao, Ge Wang
Activation of fibroblast growth factor receptor (FGFR) signaling occurs in various cancers, including esophageal squamous cell carcinoma (ESCC), however, the effect of targeting FGFR in ESCC is not clear. Herein, we examined the phosphorylation level of FGFR1Y654 (p‑FGFR1) in ESCC cell lines and tumor tissues, as well as the cancer cell killing effects of gefitinib and FGFR inhibitor AZD4547 in combination form or alone in ESCC cells. Immunohistochemistry staining was used to detect the expression level of p‑FGFR1 in 87 ESCC specimens...
March 8, 2018: Oncology Reports
Silvia Martina Ferrari, Guido Bocci, Teresa Di Desidero, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Anna Fioravanti, Paola Orlandi, Sabrina Rosaria Paparo, Armando Patrizio, Simona Piaggi, Concettina La Motta, Salvatore Ulisse, Enke Baldini, Gabriele Materazzi, Paolo Miccoli, Alessandro Antonelli, Poupak Fallahi
The antitumor activity of vandetanib [a multiple signal transduction inhibitor including the RET tyrosine kinase, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) receptor (VEGFR), ERK and with antiangiogenic activity], in primary anaplastic thyroid cancer (ATC) cells, in the human cell line 8305C [undifferentiated thyroid cancer (TC)] and in an ATC‑cell line (AF), was investigated in the present study. Vandetanib (1 and 100 nM; 1, 10, 25 and 50 µM) was tested by WST‑1, apoptosis, migration and invasion assays: in primary ATC cells, in the 8305C continuous cell line, and in AF cells; and in 8305C cells in CD nu/nu mice...
March 8, 2018: Oncology Reports
Chao Qi, Yuanlei Chen, Yixuan Zhou, Xucheng Huang, Guoli Li, Jin Zeng, Zhi Ruan, Xinyou Xie, Jun Zhang
Colorectal cancer (CRC) is considered the world's fourth most deadly cancer. Its metastasis is associated with poor prognosis and weakens the effects of treatment. However, the potential molecular mechanisms and key genes involved in CRC metastasis have remained to be comprehensively elucidated. The objective of the present study was to identify the key genes and molecular pathways underlying CRC metastasis. Differentially expressed genes (DEGs) between primary CRC tissues and metastatic CRC were identified by analyzing the GSE2509 dataset from the Gene Expression Omnibus database...
March 8, 2018: Oncology Reports
Shen Wu, Nanping Ai, Qian Liu, Jingxue Zhang
Retinoblastoma (RB) is the most common primary intraocular malignancy during infancy and childhood worldwide. Numerous microRNAs (miRNAs) contribute to RB initiation and progression through the regulation of cell proliferation, cycle, apoptosis, migration, invasion and metastasis. Therefore, further investigation concerning the expression, roles and associated mechanisms of RB‑related miRNAs may be beneficial to develop novel strategies for patients with this malignancy. Recently, miRNA‑448 (miR‑448) has been reported to be aberrantly expressed and to play an important role in several types of human cancer...
March 8, 2018: Oncology Reports
Silvia Martina Ferrari, Guido Bocci, Teresa Di Desidero, Giusy Elia, Ilaria Ruffilli, Francesca Ragusa, Paola Orlandi, Sabrina Rosaria Paparo, Armando Patrizio, Simona Piaggi, Concettina La Motta, Salvatore Ulisse, Enke Baldini, Gabriele Materazzi, Paolo Miccoli, Alessandro Antonelli, Poupak Fallahi
Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor (TKI) of VEGFR1-VEGFR3, FGFR1-FGFR4, PDGFRα, RET and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) signaling networks involved in tumor angiogenesis. We have evaluated the antitumor activity of lenvatinib in primary anaplastic thyroid cancer (ATC) cells, in the human cell line 8305C (undifferentiated thyroid cancer) and in an ATC-cell line (AF). The AF cell line was obtained from the primary ATC cultures and was the one that grew over 50 passages...
March 8, 2018: Oncology Reports
Saumya S Srivastava, Hunain Alam, Sonam J Patil, Rashmi Shrinivasan, Sweta Raikundalia, Pratik Rajeev Chaudhari, Milind M Vaidya
Keratins 5/14 (K5/14) are intermediate filament proteins expressed in the basal layer of stratified epithelial cells and are known targets of p63. Previous research in our laboratory showed that upon K5/14 downregulation in oral squamous cell carcinoma (OSCC)‑derived cells, there was an increase in intracellular Notch‑1 levels and differentiation markers such as involucrin, keratin 1 and a decrease in tumorigenic potential in vivo. However, the molecules involved in the K14 regulated cell differentiation and transformation are not known to date...
March 6, 2018: Oncology Reports
Kun Li, Jiwei Guo, Yan Wu, Dan Jin, Hong Jiang, Chengxia Liu, Chengyong Qin
Colon cancer is a commonly diagnosed cancer that often has a poor prognosis. Combined with the development of drug resistance to cancer treatment agents the treatment efficacy of colon cancer can be limited. Activation of the oncogene YAP has been shown to be related to colon cancer progression and is associated with poor prognosis, drug resistance and metastasis, even under treatment. Cisplatin (DDP) is a commonly used drug that can control carcinoma progression, although its mechanisms are poorly understood...
March 6, 2018: Oncology Reports
Kejuan Song, Teng Lv, Yulong Chen, Yuchao Diao, Qin Yao, Yankui Wang
Ovarian cancer is a highly metastatic malignancy and a leading cause of cancer-related death in postmenopausal women. Emodin is a natural anthraquinone isolated from several traditional Chinese medicines including Rhubarb and Polygonum cuspidatum. Recently, emodin was demonstrated to reduce the growth of human ovarian carcinoma cells. However, the mechanism remains unclear. In the present study, we identified that transforming growth factor (TGF)-β2 was significantly affected by emodin treatment in A2780 cells using microarray analysis...
March 6, 2018: Oncology Reports
Xiaowu Liu, Chuize Kong, Zhe Zhang
Bladder cancer (BCa) is the most common urological cancer, and more and more evidence suggests that microRNAs (miRNAs) play an important role in BCa pathogenesis. Aberrant miR-130b expression has been reported in several types of cancers. The aim of the present study was to elucidate the effects of miR-130b on BCa progression. miR‑130b expression in BCa cell lines and tissues was detected using real-time PCR (RT-PCR), and vestigial-like protein 4 (VGLL4) expression in tissue specimens and BCa cells that had been transfected with miR-130b mimics and inhibitors was detected using western blotting...
March 6, 2018: Oncology Reports
Susanna Nuvoli, Sarah Galassi, Ilaria Gelo, Gaia Rocchitta, Alessandro Fancellu, Pier Andrea Serra, Giuseppe Madeddu, Angela Spanu
The aim of the present study was to investigate the usefulness of molecular breast imaging (MBI) in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy. A consecutive series of 43 female patients with large or locally advanced primary breast cancer, scheduled for surgery following neoadjuvant therapy, was retrospectively reviewed. Prior to surgery, all patients underwent MBI using a high‑resolution semiconductor‑based device for image acquisition. MBI data were correlated with surgical histopathological findings...
March 6, 2018: Oncology Reports
Shenghua Liu, Haowen Jiang, Hui Wen, Qiang Ding, Chenchen Feng
Bladder cancer is the most common tumor of the urinary tract. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), a gene encoding the 14-3-3ζ protein, has been observed to be frequently amplified in bladder cancer. However, the role of 14-3-3ζ in various types of cancer is controversial. With reproduction of The Cancer Genome Atlas database, we searched the correlation of YWHAZ expression with survival outcomes of multiple cancers in silico. Our results revealed that only in bladder cancer was there a positive survival trend with YWHAZ overexpression...
March 5, 2018: Oncology Reports
Tian Liao, Yuan-Jin Wang, Jia-Qian Hu, Yu Wang, Li-Tao Han, Ben Ma, Rong-Liang Shi, Ning Qu, Wen-Jun Wei, Qing Guan, Jun Xiang, Jia-Ying Chen, Guo-Hua Sun, Duan-Shu Li, Xiang-Ming Mu, Qing-Hai Ji
KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. In the present study, we identified that KMT5A was elevated in 50 pairs of papillary thyroid cancer tissue samples and in cell lines K1 and TPC-1 by qRT-PCR and western blotting, as well as by immunohistochemical staining. CCK-8 assay and flow cytometric analysis revealed that inhibition of KMT5A attenuated proliferation and induced apoptosis...
March 5, 2018: Oncology Reports
Yutaka Mizuno, Kentaro Maemura, Yoshihisa Tanaka, Azumi Hirata, Sugiko Futaki, Hiroki Hamamoto, Kohei Taniguchi, Michihiro Hayashi, Kazuhisa Uchiyama, Masa-Aki Shibata, Yoshinori Otsuki, Yoichi Kondo
Delta-like 3 (DLL3) is a member of the Delta/Serrate/Lag-2 family of ligands for the Notch receptor and plays a role in Notch signaling. We have previously revealed that the expression of DLL3 is silenced by aberrant DNA methylation and that overexpression of DLL3 in the HuH2 hepatocellular carcinoma (HCC) cell line induced apoptosis. In the present study, we first confirmed the methylation of DLL3 in HuH2 cells and analyzed the methylation status of the DLL3 promoter region by bisulfite sequencing. Furthermore, we investigated whether other epigenetic modifications, such as histone acetylation and histone methylation, affected the expression of DLL3...
March 5, 2018: Oncology Reports
Youjun Luo, Xue Chen, Lumeng Luo, Qi Zhang, Caixia Gao, Xibing Zhuang, Sujuan Yuan, Tiankui Qiao
Ionizing radiation (IR) is the main modality for locoregional control of unresectable gastric cancer (GC). [6]-Gingerol is an active major phenolic compound isolated from ginger (Zingiber officinale Roscoe), and it has been demonstrated to possess antitumor activity in previous studies. In the present study, we aimed to evaluate the potential activity of [6]-gingerol as a radiosensitizer and to further explore the underlying mechanism. A CCK-8 assay revealed that [6]-gingerol inhibited the cell viability of HGC-27 cells in a dose-dependent manner (P<0...
March 5, 2018: Oncology Reports
Pedro Miguel Lacal, Maria Grazia Atzori, Federica Ruffini, Lucio Tentori, Grazia Graziani
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor activated by the angiogenic factors VEGF‑A and placental growth factor (PlGF). While VEGF‑A binds to both VEGFR‑1 and VEGFR‑2, PlGF interacts exclusively with VEGFR‑1 triggering a signaling pathway involved in: i) tumor‑associated angiogenesis; ii) chemotaxis and invasion of the extracellular matrix (ECM) by cancer cells; and iii) mobilization of bone marrow‑derived myeloid cells that generate tumor‑associated macrophages...
March 5, 2018: Oncology Reports
Zhiyuan Zhang, Sen Wang, Dongjian Ji, Wenwei Qian, Qingyuan Wang, Jie Li, Jiou Gu, Wen Peng, Tao Hu, Bing Ji, Yue Zhang, Shijia Wang, Yueming Sun
Competing endogenous RNAs (ceRNAs) render the functions of long non‑coding RNAs (lncRNAs) more complicated during cancer processes. Potential lncRNA biomarkers and their roles as ceRNAs have not been clearly described for rectal adenocarcinoma (READ). In the present study, we extracted data from The Cancer Genome Atlas (TCGA) including data from 167 tumor samples and 10 adjacent non‑tumor samples. A total of 202 lncRNAs, 190 microRNAs (miRNAs) and 1,530 mRNAs were identified as READ‑specific RNAs [log2(fold‑change)>2, FDR<0...
March 5, 2018: Oncology Reports
Yan Feng, Li-Li Zu, Lei Zhang
We investigated the role of microRNA-26b signaling in mediating the tumor growth of human liver cancer. MicroRNA-26b expression was observably downregulated in human liver cancer tissue. Forced upregulation of microRNA-26b had anticancer effects, inhibited cell proliferation, induced apoptosis and promoted Bax and caspase-3/-9 protein expression in a liver cancer cell line as determined by MTT assay, flow cytometry and western blot analysis. MicroRNA-26b significantly suppressed the PI3K/Akt and NF-κB/MMP-9/VEGF pathways...
March 1, 2018: Oncology Reports
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