journal
MENU ▼
Read by QxMD icon Read
search

Oncology Reports

journal
https://www.readbyqxmd.com/read/27878298/trail-overexpression-co-regulated-by-egr1-and-hre-enhances-radiosensitivity-of-hypoxic-a549-cells-depending-on-its-apoptosis-inducing-role
#1
Yan-Ming Yang, Fang Fang, Xin Li, Lei Yu, Zhi-Cheng Wang
Ionizing radiation can upregulate the expression levels of TRAIL and enhance tumor cell apoptosis. While Early growth response 1 (Egr1) gene promoter has radiation inducible characteristics, the expression for exogenous gene controlled by Egr1 promoter could be enhanced by ionizing radiation, but its efficiency is limited by tissue hypoxia. Hypoxia response elements (HREs) are important hypoxic response regulatory sequences and sensitivity enhancers. Therefore, we chose TRAIL as the gene radiotherapy to observe whether it is regulated by Egr1 and HER and its effects on A549 cells and its mechanism...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878294/arctigenin-a-lignan-from-arctium-lappa-l-inhibits-metastasis-of-human-breast-cancer-cells-through-the-downregulation-of-mmp-2-9-and-heparanase-in-mda-mb-231-cells
#2
Chenghua Lou, Zhihui Zhu, Yaping Zhao, Rui Zhu, Huajun Zhao
Arctigenin is a bioactive lignan isolated from the seeds of Arctium lappa L. which has been widely used as a diuretic and a diaphoretic in Traditional Chinese Medicine. In the present study, the authors investigated the effects of arctigenin on tumor migration and invasion in aggressive human breast cancer cells. The MTT assay results showed that arctigenin did not show a significant cytotoxic effect on the cell viability of MDA-MB-231 cells. However, wound healing migration and Boyden chamber invasion assays demonstrated that arctigenin significantly inhibited in vitro migration and invasion of the MDA-MB-231 cells...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878290/-oleocanthal-exerts-anti-melanoma-activities-and-inhibits-stat3-signaling-pathway
#3
Yanli Gu, Jing Wang, Lixin Peng
Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addition, OC inhibited proliferation, migration, invasion and tube formation in human umbilical vascular endothelial cells. In vivo, it exhibited potent activity in suppressing tumor growth in a subcutaneous xenograft model...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878289/oncogenic-function-of-plac1-on-the-proliferation-and-metastasis-in-hepatocellular-carcinoma-cells
#4
Yuan Wu, Xiaocong Lin, Xiaoqing Di, Yonghua Chen, Hanning Zhao, Xin Wang
Placenta-specific protein 1 (Plac1), which is selectively expressed in the placental syncytiotrophoblast in adult normal tissues, plays an essential role in normal placental and embryonic development. Accumulating evidence suggests that enhanced Plac1 expression is closely associated with the progression of human cancer. Whether Plac1 contributes to the pathophysiology of hepatocellular carcinoma (HCC) remains unclear. In the present study, our data revealed that the expression of Plac1 in human HCC tissues was upregulated, which significantly correlated with metastasis of HCC...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878280/loss-of-mir-638-promotes-invasion-and-epithelial-mesenchymal-transition-by-targeting-sox2-in-hepatocellular-carcinoma
#5
Yu Zhang, Di Zhang, Jiong Jiang, Lei Dong
Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. Several studies have demonstrated that miR-638 expression was dysregulated in various human cancers. However, the clinical significance and underlying mechanisms of miR-638 involved in HCC remain to be elucidated. Herein, we confirmed that a reduced miR-638 expression was present in HCC tissues and cell lines. Our clinical analysis revealed that the downregulated miR-638 expression was significantly correlated with poor prognostic features including high Edmondson-Steiner grade, venous infiltration and advanced tumor-node-metastasis (TNM) stage...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878295/silencing-of-the-long-non-coding-rna-neat1-suppresses-glioma-stem-like-properties-through-modulation-of-the-mir-107-cdk6-pathway
#6
Xiaoli Yang, Zheng Xiao, Xiaowei Du, Lina Huang, Ganqin Du
Developing novel strategies against glioma remains a significant challenge. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) significantly contributes to the progression of many human cancers, while glioma stem cells (GSCs) are believed to be responsible for tumor progression. However, whether NEAT1 alters the stem-like properties of GSC cells remains unknown. Using microbeads, CD133+ cells were isolated and were found to possess glioma stem cell properties. Using siRNA, NEAT1 was knocked down in the sorted CD133+ U87 glioma cells...
November 22, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878288/microrna-6826-and-6875-in-plasma-are-valuable-non%C3%A2-invasive-biomarkers-that-predict-the-efficacy-of-vaccine-treatment-against-metastatic-colorectal-cancer
#7
Taiki Kijima, Shoichi Hazama, Ryouichi Tsunedomi, Hironori Tanaka, Hiroko Takenouchi, Shinsuke Kanekiyo, Yuka Inoue, Masao Nakashima, Michihisa Iida, Kazuhiko Sakamoto, Nobuaki Suzuki, Shigeru Takeda, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Kiyotaka Okuno, Hiroaki Nagano
Various vaccine treatments against metastatic colorectal cancer have been developed and applied. However, to improve the efficacy of immunotherapy, biomarkers that can predict the effects are needed. It has been reported that various microRNAs (miRNAs) in peripheral blood may be useful as non-invasive biomarkers. In this study, miRNAs influencing the efficacy of vaccine treatment were screened for in a microarray analysis of 13 plasma samples that were obtained from patients prior to vaccine treatment. To validate the screening results, real-time RT-PCR was performed using 93 plasma samples obtained from patients prior to vaccine treatment...
November 22, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878284/antitumor-effect-of-the-combination-of-manumycin%C3%A2-a-and-immodin-is-associated-with-antiplatelet-activity-and-increased-granulocyte-tumor-infiltration-in-a-4t1-breast-tumor-model
#8
Peter Solár, Veronika Sačková, Gabriela Hrčková, Vlasta Demečková, Monika Kassayová, Bianka Bojková, Dagmar Mudroňová, Soňa Gancarčíková, Rastislav Jendželovský, Peter Fedoročko
Manumycin A is a natural antibiotic isolated from Streptomyces parvulus with broad range of biological activities including antineoplastic activity in several in vitro and in vivo cancer models. Immodin [dialyzable leukocyte extract (DLE)] is a dialysate released from disintegrated blood leukocytes of healthy donors which exerts immunonormalizing effects on cell-mediated immune responses. The aim of the present study was to explore the antitumor potential of the combination of manumycin A and Immodin in an experimental breast cancer model...
November 22, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878283/hes5-promotes-cellular-proliferation-of-non-small-cell-lung-cancer-through-stat3-signaling
#9
Shudong Gu, Rui Zhang, Jun Gu, Xia Li, Liting Lv, Jingting Jiang, Zhen Xu, Shuo Wang, Cui Shi, Dan Ping Wang, Changping Wu
HES5 is a transcription factor activated downstream of the Notch pathway and regulates cell differentiation in multiple tissues. Disruption of its normal expression has been associated with developmental diseases and cancer. But its role in non-small cell lung cancer (NSCLC) remains elusive. Western blot analysis and immunohistochemistry assays demonstrated that HES5 expression was frequently increased in NSCLC tumor tissues and cell lines. Moreover, immunohistochemistry analysis revealed that upregulation of HES5 expression was positively correlated with a more invasive tumor phenotype and poor prognosis...
November 22, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878282/the-importance-of-mitochondrial-folate-enzymes-in-human-colorectal-cancer
#10
Masaaki Miyo, Masamitsu Konno, Hugh Colvin, Naohiro Nishida, Jun Koseki, Koichi Kawamoto, Kenta Tsunekuni, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Folate plays a pivotal role in the one-carbon metabolism needed for methylation reactions, nucleotide synthesis, and DNA repair. Although folate metabolism was recently shown to be associated with carcinogenesis in some solid tumors, the importance of folate metabolism in colorectal cancer remains unclear. In the present investigation we found that expression of three mitochondrial folate metabolic enzymes, serine hydroxymethyl transferase (SHMT2), methylenetetrahydrofolate dehydrogenase (MTHFD2) and aldehyde dehydrogenase 1 family member L2 (ALDH1L2), were upregulated in human colorectal tumor tissues compared to normal tissues...
November 22, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878292/bmi-1-interacts-with-smek1-and-inactivates-smek1-induced-apoptotic-cell-death
#11
Boh-Ram Kim, Youngjoo Kwon, Seung Bae Rho
The B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) protein is activated in various types of tumors and associated with cancer development and tumor progression. However, the working role of BMI-1 in cellular signaling is not understood completely. In this study, we revealed one possible biologic mechanism of BMI-1 in cancer progression in vitro using a human ovarian tumor cell system. Suppressor of MEK1 (sMEK1), a pivotal regulator involved in the cellular biological response mechanism, was identified as a BMI-1-binding protein...
November 21, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878291/adenovirus-mediated-truncated-bid-overexpression-induced-by-the-cre-loxp-system-promotes-the-cell-apoptosis-of-cd133-ovarian-cancer-stem-cells
#12
Qifang Long, Ru Yang, Weixian Lu, Weipei Zhu, Jundong Zhou, Cui Zheng, Dongmei Zhou, Ling Yu, Jinchang Wu
Cancer stem cells are a small subset of cancer cells that contribute to cancer progression, metastasis, chemoresistance and recurrence. CD133-positive (CD133+) ovarian cancer cells have been identified as ovarian cancer stem cells. Adenovirus-mediated gene therapy is an innovative therapeutic method for cancer treatment. In the present study, we aimed to develop a new gene therapy to specifically eliminate CD133+ ovarian cancer stem cells by targeting CD133. We used the Cre/LoxP system to augment the selective expression of the truncated Bid (tBid) gene as suicide gene therapy in CD133+ ovarian cancer stem cells...
November 21, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878307/hmga2-regulates-epithelial-mesenchymal-transition-and-the-acquisition-of-tumor-stem-cell-properties-through-twist1-in-gastric-cancer
#13
Wei Li, Ziwei Wang, Lang Zha, Dequan Kong, Gang Liao, Hui Li
High expression of high mobility group protein A2 (HMGA2) is correlated with the invasiveness of gastric cancer and is an independent prognostic factor. The reason may be that HMGA2 promotes epithelial-mesenchymal transition (EMT) and the acquisition of tumor stem cell properties, yet the mechanism remains unclear. In this study, immunohistochemistry and western blot analysis revealed that the expression of HMGA2 and Twist-related protein 1 (TWIST1) in gastric carcinoma tissues was higher than that in the peritumoral tissues and that the expression levels of these two proteins were positively correlated...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878305/mir-148a-suppresses-human-renal-cell-carcinoma-malignancy-by-targeting-akt2
#14
Huiyan Cao, Zhiming Liu, Rong Wang, Xiaodong Zhang, Wenfa Yi, Guanyuan Nie, Yong Yu, Guolu Wang, Mingting Zhu
MicroRNA-148a (miR-148a) has been reported to be deregulated in different tumor types, whereas the biological function of miR-148a in renal cell carcinoma (RCC) largely remains unexplored. In the present study we investigated the clinical significance, biological effects, and the underlying molecular mechanisms of miR-148 in RCC. Here, we showed that miR-148a was significantly downregulated in RCC tissues and cell lines. Low expression of miR-148a in RCC tissues was associated with large tumor size, advanced TNM stage, and lymph node metastasis...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878304/upregulation-of-mek5-by-stat3-promotes-breast-cancer-cell-invasion-and-metastasis
#15
Fang Liu, Hao Zhang, Hui Song
Mitogen extracellular-signal-regulated kinase kinase 5 (MEK5) plays an important role in promoting cell proliferation and tumorigenesis. The aberrant expression of MEK5 has been reported in various malignant diseases including cancers of breast, prostate, lung, colorectal and brain. However, the function and regulation of MEK5 signaling pathway are ambiguous and remain elusive with respect to its oncogenic roles in various cancers, especially in the regulation of the initiation and progression of cancer invasion and metastasis...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878302/triptolide-inhibits-tumor-growth-by-induction-of-cellular-senescence
#16
Ruidong Li, Xiaofei Zhang, Xiaoying Tian, Conghuan Shen, Quanbao Zhang, Yihong Zhang, Zhengxin Wang, Feifei Wang, Yifeng Tao
Cellular senescence, an irreversible growth arrest of cells, is involved in protection against cancer. Triptolide (TPL) plays an important role in immunosuppressive, anti-fertility, anti-cystogenesis and anticancer activities. However, effect and mechanism of TPL on cellular senescence-associated antitumor is rarely reported. Herein HepG2 cells were used to explore the effect of TPL on tumor growth and cellular senescence. We showed that TPL inhibited tumor cell proliferation and growth in vitro and in vivo, accelerated cellular senescence and arrested cells at G0/G1 phase...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878285/trichostatin-a-increases-radiosensitization-of-tongue-squamous-cell-carcinoma-via-mir%C3%A2-375
#17
Lingfei Jia, Shan Zhang, Yiping Huang, Yunfei Zheng, Yehua Gan
Trichostatin A (TSA), a histone deacetylase inhibitor, is used as an anti-carcinogenic and radiosensitizing agent in various cancers. However, the role and mechanism underlying its radiosensitization of tongue squamous cell carcinoma (TSCC) remains unclear. Thus, in this study we aimed to confirm the promotion of miR‑375 expression by TSA, and to investigate the effects of TSA and miR‑375 in the radiosensitivity of TSCC cells. The results showed that TSA had significant radiosensitizing effects on TSCC cells and miR‑375 overexpression had effects similar to TSA in sensitizing these cells to radiotherapy...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878277/synthetic-paclitaxel-octreotide-conjugate-reverses-the-resistance-of-paclitaxel-in-a2780-taxol-ovarian-cancer-cell-line
#18
Yang Shen, Xiao-Yu Zhang, Xi Chen, Li-Li Fan, Mu-Lan Ren, Yong-Ping Wu, Kenneth Chanda, Shi-Wen Jiang
The high mortality of ovarian cancer is partly due to the frequent resistance of ovarian cancer to current chemotherapy agents such as paclitaxel and platinum. Somatostatin analogue (SSTA) has been shown to inhibit the proliferation of some tumors through binding to somatostatin receptor (SSTR) and activation of Ras-, Rapl- and B-Raf-dependent extracellular signal-regulated kinase 2 (Erk2). It was reported that paclitaxel-octreotide conjugate (POC) exhibited enhanced tumor growth inhibition with reduced toxicity...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878272/mir-20b-reduces-5-fu-resistance-by-suppressing-the-adam9-egfr-signaling-pathway-in-colon-cancer
#19
Qiang Fu, Jing Cheng, Jindai Zhang, Yonglei Zhang, Xiaobing Chen, Suxia Luo, Jianguo Xie
Chemoresistance is a major obstacle to cancer therapy including that of colon cancer (CC). Although the dysregulation of many miRNAs has been implicated in 5-fluorouracil (5-FU) resistance in CC cells, the specific role of miR-20b in chemoresistance has not been documented. In the present study, we first determined the expression of miR-20b by RT-PCR and the levels of a disintegrin and metalloprotease 9 (ADAM9) and epidermal growth factor receptor (EGFR) by western blotting in CC and adjacent non-cancerous tissues from 5-FU-sensitive or -resistant CC patients...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27878299/antioxidant-and-antitumor-activities-of-capparis-spinosa-l-and-the-related-mechanisms
#20
Lei Yu, Jinghhui Yang, Xin Wang, Bo Jiang, Yongxue Sun, Yubin Ji
The 'ethnodrug' Capparis spinosa L. has several pharmacological activities. First, it was found in previous experiments that an ethyl acetate extract of Capparis spinosa L. (CSE) exhibited antioxidant activity. In order to further research this finding, the present study investigate the blood biochemical indices, injury, energy metabolism, oxidative damage and mitochondrial membrane potential (Δψm) level of cardiac cells to study the effect of CSE on doxorubicin-induced cardiac toxicity. CSE had protective effects on the cardiac toxic effect of doxorubicin, and decreased the activity of lactic dehydrogenase (LDH) and creatine kinase (CK)...
November 16, 2016: Oncology Reports
journal
journal
31639
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"