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Oncology Reports

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https://www.readbyqxmd.com/read/30015982/silencing-of-cdca5-inhibits-cancer-progression-and-serves-as-a-prognostic-biomarker-for-hepatocellular-carcinoma
#1
Jianlin Wang, Congcong Xia, Meng Pu, Bin Dai, Xisheng Yang, Runze Shang, Zhen Yang, Ruohan Zhang, Kaishan Tao, Kefeng Dou
Cell division cycle associated 5 (CDCA5) has been associated with the progression of several types of cancers. However, its possible role and mechanism in hepatocellular carcinoma (HCC) remain unknown. In the present study, immunohistochemical staining and real‑time PCR were used to assess CDCA5 protein and mRNA levels in clinical samples. Statistical analysis was performed to explore the clinical correlation between CDCA5 protein expression and clinicopathological features and overall survival in HCC patients...
July 17, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015962/knockdown-of-metadherin-inhibits-cell-proliferation-and-migration-in-colorectal-cancer
#2
Jian-Wang Li, Chun-Zhen Huang, Jian-Hua Li, Jian-Hua Yuan, Qiong-Hui Chen, Wei-Fang Zhang, Zhen-Sheng Xu, Ying-Ping Liu, Yong Li, Mei-Xiao Zhan, Li-Gong Lu
Metadherin (MTDH) is a multifunctional oncogene involved in tumor cell migration and metastasis through regulating a number of oncogenic signaling pathways in various human malignancies. Previous studies have demonstrated that MTDH is overexpressed in human colorectal cancer (CRC) and associated with cancer progression and a poor prognosis. However, the underlying mechanisms remain largely unknown. The present study investigated the expression and role of MTDH in CRC cells as well as the underlying mechanism of this...
July 17, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015910/nicotine-enhances-store%C3%A2-operated-calcium-entry-by-upregulating-hif%C3%A2-1%C3%AE-and-socc-components-in-non%C3%A2-small-cell-lung-cancer-cells
#3
Yan Wang, Jianxing He, Hua Jiang, Qi Zhang, Haihong Yang, Xiaoming Xu, Chenting Zhang, Chuyi Xu, Jian Wang, Wenju Lu
Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was evaluated by BrdU incorporation assay. The SOCE and basal [Ca2+]i in NSCLC A549 cells were determined using Fura‑2 fluorescence microscopy. The mRNA and protein expression levels were determined by real‑time quantitative PCR and western blotting, respectively...
July 17, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015983/downregulation-of-long-non%C3%A2-coding-rna-uca1-enhances-the-radiosensitivity-and-inhibits-migration-via-suppression-of-epithelial%C3%A2-mesenchymal-transition-in-colorectal-cancer-cells
#4
Xiaodong Yang, Wei Liu, Xiaohui Xu, Junjia Zhu, Yong Wu, Kui Zhao, Songbin He, Ming Li, Yongyou Wu, Shuyu Zhang, Jianping Cao, Zhenyu Ye, Chungen Xing
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and common cause of cancer‑related deaths. Radiotherapy has become a routine treatment for CRC. However, radioresistance affects therapeutic efficacy. Long non‑coding RNA urothelial carcinoma associated 1 (UCA1) has been demonstrated to be overexpressed in several tumors and predicts a poor prognosis. In the present study, we revealed that lncRNA‑UCA1 was overexpressed in colorectal cancer tissue and colon cancer cells when compared to normal tissue and cells...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015981/nfib-promotes-cell-growth-aggressiveness-metastasis-and-emt-of-gastric-cancer-through-the-akt-stat3-signaling-pathway
#5
Chuanqing Wu, Xiaojie Zhu, Weizhen Liu, Tuo Ruan, Wenze Wan, Kaixiong Tao
Nuclear factor I/B (NFIB) plays a crucial role in the progression of several types of cancers. However, its role in gastric cancer (GC) remains unclear. The present study revealed that NFIB was highly expressed in GC tissues and was positively associated with the clinicopathological features of GC patients. Downregulation of NFIB inhibited the tumor growth, migration and aggression of MKN45 and HGC27 cells in vitro. In addition, NFIB expression promoted epithelial‑mesenchymal transition (EMT), which was accompanied with decreased E‑cadherin and increased vimentin expression...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015980/tipe2-inhibits-gc-via-regulation-of-cell-proliferation-apoptosis-and-inflammation
#6
Zhenhe Lin, Wenming Liu, Chuanxing Xiao, Yanyun Fan, Guohong Zhuang, Zhongquan Qi
Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and various epithelial cells and serves an important role in the maintenance of human physiological immune homeostasis. In our preliminary study, we found that the expression of TIPE2 was downregulated or absent in GC tissues compared with normal gastric mucosa tissues, indicating that TIPE2 may play a significant role in the development of GC...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015979/analysis-of-the-causes-of-the-misdiagnosis-of-hereditary-spherocytosis
#7
Shiyue Ma, Xuelian Deng, Lin Liao, Zengfu Deng, Yuling Qiu, Hongying Wei, Faquan Lin
Hereditary spherocytosis (HS) is an inherited hemolytic disease with clinical diversities. The aim of the present study was to examine the reasons for prolonged misdiagnosis and mistherapy of HS in a Chinese patient, and to summarize the laboratory screening and treatment methods for this disease in increasing the knowledge towards HS. Clinical data of the proband was reviewed. The proband was first screened by detection of eosin-5'-maleimide (EMA)-labeled red blood cells (RBCs) using flow cytometry. The type of protein defect in the extracted RBC membrane proteins was confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015978/pin2-trf1%C3%A2-binding-protein-x1-inhibits-colorectal-cancer-cell-migration-and-invasion-in-vitro-and-metastasis-in-vivo-via-the-nuclear-factor%C3%A2-%C3%AE%C2%BAb-signaling-pathway
#8
Tao Jiang, Haiqing Li, Ranran Jiang, Hailong Li, Pingfu Hou, Yansu Chen, Jin Bai, Jun Song
Pin2/TRF1‑binding protein X1 (PinX1) functioned as a potent inhibitor of telomerase, which was also widely considered to be a sufficient tumor suppressor. Previous studies have demonstrated that PinX1 expression was reduced in several types of cancer and was associated with poor overall survival. However, little is known regarding the role of PinX1 in colorectal cancer (CRC). The present study investigated PinX1 expression via immunostaining of CRC tissue microarrays consisting of tumor and adjacent non‑cancerous tissues (ANCT) from 568 patients...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015977/overexpression-of-mir%C3%A2-221-and-mir%C3%A2-222-in-the-cancer-stroma-is-associated-with-malignant-potential-in-colorectal-cancer
#9
Michihisa Iida, Shoichi Hazama, Ryouichi Tsunedomi, Hironori Tanaka, Hiroko Takenouchi, Shinsuke Kanekiyo, Yukio Tokumitsu, Shinobu Tomochika, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Nobuaki Suzuki, Shigeru Takeda, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Koji Fujita, Masahiko Kuroda, Hiroaki Nagano
The cancer stroma is important in cancer development, however, whether the aberrant expression of microRNAs (miRNAs) in the cancer stroma is associated with cancer progression remains to be fully elucidated. The aim of the present study was to identify the miRNAs associated with liver metastasis in the cancer stroma of human colorectal cancer (CRC). Using laser capture microdissection, cancer stroma was obtained from the primary lesion of six patients with CRC with liver metastasis (CRCwLM) and six patients with CRC without liver metastasis (CRCwoLM), and miRNA microarray analysis was performed...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015976/let%C3%A2-7i%C3%A2-5p-inhibits-the-proliferation-and-metastasis-of-colon-cancer-cells-by-targeting-kallikrein%C3%A2-related-peptidase-6
#10
Jingyi Song, Lijing Wang, Qingxia Ma, Yuecheng Yang, Zhengtao Yang, Bin Wang, Ningning He
Colorectal cancer is one of the most common types of malignancies worldwide, and as it is often diagnosed at an advanced stage, it is a serious threat to human health. MicroRNAs are important regulators of the growth and metastasis of colon cancer (CC). In the present study, the results demonstrated that kallikrein‑related peptidase 6 (KLK6) plays a critical role in suppressing colon carcinoma progression. To further investigate whether microRNAs affect the impact of KLK6, a bioinformatics approach was employed, which indicated that let‑7i‑5p may directly target KLK6...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015950/bmp9-inhibits-the-growth-of-breast-cancer-cells-by-downregulation-of-the-pi3k-akt-signaling-pathway
#11
Shu Li, Hongying Dai, Yong He, Shusheng Peng, Tianjin Zhu, Yang Wu, Chenwei Li, Ke Wang
Bone morphogenetic protein 9 (BMP9) is a member of the BMP family, which is involved in the regulation of tumor biogenesis, development and metastasis. The present study aimed to investigate whether BMP9 inhibits the growth of MDA‑MB‑231 breast cancer cells via the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathway. It was shown that the expression level of BMP9 was significantly decreased, while that of phosphorylated Akt (p‑Akt) was markedly increased in breast cancer tissues compared with these levels in the normal adjacent tissues...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015936/high-expression-of-microrna%C3%A2-31-and-its-host-gene-loc554202-predict-favorable-outcomes-in-patients-with-colorectal-cancer-treated-with-oxaliplatin
#12
Yalun Li, Shijie Xin, Huizhe Wu, Chengzhong Xing, Liren Duan, Weifeng Sun, Xiaoyun Hu, Ruoran Lin, Fangxiao Zhang
The expression levels of microRNA‑31 (miR‑31) and LOC554202 have been previously investigated in colorectal cancer (CRC) and their oncogenic and/or tumor suppressive roles have been described. The aim of the present study was to examine the role of miR‑31 and its host gene LOC554202 in the prognosis of patients with CRC. Patients with CRC treated with oxaliplatin‑based chemotherapy between June 2005 and March 2010 were recruited to the First Affiliated Hospital of China Medical University. Tumor and adjacent mucosal tissues were collected...
July 13, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015959/developing-a-radiosensitivity-gene-signature-for-caucasian-patients-with-breast-cancer
#13
Ye Ji, Qinghua Jiang, Guohao Jian, Haitong Sun, Yamin Wang, Hualong Qin, Shuyu Zhang, Jianping Cao, Zaixiang Tang
Adjuvant radiotherapy is an important clinical treatment option for patients with breast cancer. However, for Caucasian patients, the clinical benefit of adjuvant radiotherapy can differ from African‑American patients with respect to the overall survival. The goal of the current study was to develop a gene signature and to pre‑identify patients likely to benefit from radiotherapy. Using publicly available breast cancer data from The Cancer Genome Atlas, a new cross‑validation procedure was proposed for developing a gene signature and predicting radiosensitive patients...
July 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015956/moxidectin-inhibits-glioma-cell-viability-by-inducing-g0-g1-cell-cycle-arrest-and-apoptosis
#14
Dandan Song, Hongsheng Liang, Bo Qu, Yijing Li, Jingjing Liu, Chen Chen, Daming Zhang, Xiangtong Zhang, Aili Gao
Moxidectin (MOX), a broad‑spectrum antiparasitic agent, belongs to the milbemycin family and is similar to avermectins in terms of its chemical structure. Previous research has revealed that milbemycins, including MOX, may potentially function as effective multidrug resistance agents. In the present study, the impact of MOX on the viability of glioma cells was examined by MTT and colony formation assay, and the molecular mechanisms underlying MOX‑mediated glioma cell apoptosis were explored by using flow cytometry and apoptosis rates...
July 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015954/mir%C3%A2-448-targets-rab2b-and-is-pivotal-in-the-suppression-of-pancreatic-cancer
#15
Jing Jin, Yingsheng Wu, Dongkai Zhou, Qiang Sun, Weilin Wang
Improvements in survival rates for pancreatic cancer have been slow and the morality rate continues to increase in patients. MicroRNA (miR)‑448 is reported to be significantly downregulated in several types of cancer. In this study, Rab2B is target of miR‑488 was confirmed by bioinformatics analysis and validated using a luciferase reporter assay. A total of 72 cases of pancreatic cancer in patients diagnosed at The First Affiliated Hospital, School of Medicine, Zhejiang University (Hangzhou, China) were enrolled, and cancer specimens and their adjacent normal tissues were collected for analysis...
July 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015952/synergistic-effects-of-tetrandrine-combined-with-ionizing-radiation-on-a-murine-colorectal-carcinoma%C3%A2-bearing-mouse-model
#16
Wei-Chan Lin, Wei-Hsun Wang, Yi-Hsien Lin, Jyh-Der Leu, Shan-Yun Cheng, Yu-Jen Chen, Jeng-Jong Hwang
Tetrandrine (TET), a traditional Chinese clinical agent, has been used for the treatment of many diseases, including cancers. The purpose of the present study was to investigate the combined effects of TET and ionizing radiation (IR) on murine CT26 colorectal adenocarcinoma cells in vitro and in vivo. A CT26 cell line transfected with dual HSV‑1 thymidine kinase and firefly luciferase (luc) reporter genes was used. The half‑maximal inhibitory concentration (IC50) of TET in CT26/tk‑luc cells was ~10 µM...
July 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015944/microrna%C3%A2-449a-is-a-potential-predictor-of-colitis%C3%A2-associated-colorectal-cancer-progression
#17
Yun Feng, Yu-Wei Dong, Yun-Na Song, Jun-Hua Xiao, Xing-Ya Guo, Wei-Liang Jiang, Lun-Gen Lu
An early diagnosis of colitis‑associated colorectal cancer (CAC) is important for its clinical management. However, it is currently difficult to distinguish the different stages of CAC development. MicroRNA dysregulation is common in human colorectal disorders, however little is known regarding whether miRNA affects tumor progression by regulating inflammation. In the present study, we identified a novel miRNA (miR‑449a), the expression of which was significantly reduced in CAC tissues than in paired adjacent non‑cancerous tissues (ANTs)...
July 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015943/ese%C3%A2-1-suppresses-the-growth-invasion-and-migration-of-human-nsclc-cells-and-tumor-formation-in-vivo
#18
Zhiyuan Lou, Bok-Soon Lee, Taekyu Ha, Yanrui Xu, Haeng-Jun Kim, Chul-Ho Kim, Seong-Ho Lee
Lung cancer is the first leading cause of cancer‑related death in the United States. Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer and is associated with a poor patient prognosis. Identification of promising molecular targets is required for the effective prevention and therapy of NSCLC. Epithelial‑specific ETS‑1 (ESE‑1) belongs to the superfamily of ETS transcription factors. The effect of ESE‑1 on tumorigenesis is controversial in several types of cancer while its role in lung cancer remains unknown...
July 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015942/apoptotic-effect-of-pyrroloquinoline-quinone-on-chondrosarcoma-cells-through-activation-of-the-mitochondrial-caspase%C3%A2-dependent-and-caspase%C3%A2-independent-pathways
#19
Ronghuan Wu, Jun Pan, Miaoda Shen, Chunyang Xing
Chondrosarcomas are malignant tumors of the bone that exhibit resistance to chemotherapy and radiation. Pyrroloquinoline quinone (PQQ) is a bacterial redox co‑factor and antioxidant that has been found to induce apoptosis in various cancer cells. This study investigated the role of PQQ in cell apoptosis of chondrosarcoma cells and the underlying pathways involved. We confirmed that PQQ was cytotoxic to chondrosarcoma SW1353 cells by a cell cytotoxicity assay. Furthermore, flow cytometry showed that the number of apoptotic cells increased in a concentration‑dependent and time‑dependent manner following PQQ treatment, but this effect was not significant in normal cells...
July 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015924/microrna%C3%A2-758-inhibits-malignant-progression-of-retinoblastoma-by-directly-targeting-pax6
#20
Jun Li, Xinying You
Accumulated studies have highlighted that the dysregulation of microRNAs (miRNAs) in retinoblastoma (RB) is a leading cause for tumourigenesis and tumour development. Therefore, the elucidation of the expression, functional roles and underlying mechanisms of miRNAs in RB will help the development of promising therapeutic methods to improve the prognosis of RB patients. The aim of this study was to detect miRNA‑758 (miR‑758) expression in RB tissues and cell lines, and to determine the effects and underlying mechanisms of miR‑758 on RB progression...
July 12, 2018: Oncology Reports
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