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Oncology Reports

Yoshimasa Sumita, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Jun Cheng, Ritsuo Takagi, Jun-Ichi Tanuma
Transcription factor SRY‑box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral squamous cell carcinoma (OSCC) remains elusive. The aim of the present study was to investigate the expression profiles of SOX9 in various oral epithelial lesions, including OSCC. We performed immunohistochemical analysis of SOX9 expression in surgical specimens of OSCC, which simultaneously exhibited different grades of epithelial lesions, and analyzed the correlation between SOX9 expression and several clinicopathological factors...
August 22, 2018: Oncology Reports
Yanliang Zheng, Jingfang Xie, Fangfang Jiang, Yunyun Li, Guanlin Chang, Haiqing Ma
MicroRNA‑21 (miR‑21) has been identified as an oncogene and confirmed to serve an important role in carcinogenesis in various types of cancer. However, the effect and mechanism of miR‑21 in oral squamous cell carcinoma (OSCC) has not been fully elucidated. In the present study, miR‑21 inhibitor and empty vector were transfected into OSCC cells, and non‑transfected cells were used as a blank control. The results indicated that when compared with the control and scramble groups, miR‑21 inhibitor suppressed the expression of miR‑21...
August 21, 2018: Oncology Reports
Cheng-Ya Dong, Jiayue Cui, Dian-He Li, Qi Li, Xin-Yu Hong
Glioma is the most common primary malignant tumor of the central nervous system. Emerging evidence has demonstrated that long non‑coding RNAs (lncRNAs) serve a major role of regulation in various types of human cancer, including glioma. However, the biological roles of thousands of lncRNAs remain unknown and require further identification. The present study investigated the functional role of lncRNA‑HOXA10‑AS in glioma. The present study examined the expression patterns of HOXA10‑AS in glioma and normal brain tissues, as well as glioma cell lines and normal human astrocytes (HA) via reverse transcription‑quantitative polymerase chain reaction...
August 21, 2018: Oncology Reports
Kuan-Ting Liu, I-Jeng Yeh, Shih-Kai Chou, Meng-Chi Yen, Po-Lin Kuo
The endoplasmic reticulum (ER) is an organelle involved in various physiological processes such as lipid metabolism, protein synthesis and folding, and cellular calcium storage. In a physiological tumor microenvironment, hypoxia, nutrient deprivation, and calcium dysregulation cause accumulation of unfolded and misfolded proteins. Such accumulation induces ER stress and unfolded protein responses (UPRs). Increased UPR signaling pathways are associated with multiple types of cancer. The influence of ER stress on acyl‑CoA metabolic enzymes is not well understood...
August 21, 2018: Oncology Reports
Jinhua Wang, Xiaohui Yang, Rong Li, Liang Wang, Yinmin Gu, Yuhui Zhao, Kuo Hsiang Huang, Tianyou Cheng, Yi Yuan, Shan Gao
Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and cancer progression. The c-Myc upregulated lncRNA MYU (VPS9D1 antisense RNA1, annotated as VPS9D1-AS1) has been reported in several common types of human cancers, which has revealed that lncRNA MYU could function as either an oncogene or a tumor-suppressor gene in different cancer types. However, the function of lncRNA MYU in prostate cancer remains unknown. In the present study, we demonstrated that lncRNA MYU is significantly upregulated in prostate cancer tissues...
August 20, 2018: Oncology Reports
Yulan Luo, Jing He, Xiangnan Tao, Helong Wang, Qiang Fang, Shujun Guo, Chuanwang Song
Vascular endothelial growth factor (VEGF) promotes angiogenesis during tumor growth, and its expression involves multiple signaling pathways and transcription factors. In the present study, transforming growth factor (TGF)‑β1 promoted upregulation of VEGF and downregulation of microRNA (miR)‑20b expression in mouse H22 hepatocellular carcinoma cells. miR‑20b negatively regulated both constitutive VEGF expression and TGF‑β1‑induced VEGF expression. The miRanda algorithm predicted that a binding site of the miR‑20b GCAAUCUGGGCACUUU sequence was present in the signal transducer and activator of transcription (STAT)3 3'‑untranslated region...
August 17, 2018: Oncology Reports
Penghui Hu, Patrick Ting-Yat Wong, Qinghua Zhou, Lianghe Sheng, Wenbo Niu, Size Chen, Meng Xu, Yiguang Lin
The multidrug resistance‑associated protein 1 (MRP1) gene has been found to be consistently overexpressed in the majority of patients with non‑small cell lung cancer (NSCLC). MRP1 is known for its ability to actively decrease intracellular drug concentration, limiting the efficacy of cancer chemotherapy; however, data on the clinical relevance of MRP1 is inconclusive. In the present meta‑analysis, all available published data were combined to provide an updated view on the clinicopathological relevance of MRP1 in patients with NSCLC...
August 17, 2018: Oncology Reports
Jianying Li, Juanhong Wang, Jun Yu, Yuling Zhao, Ya Dong, Yali Fan, Namiao Li, Yingying Zhang, Yili Wang
In the present study, we profiled β‑elemene‑regulated gene expression and investigated the effects of the silencing of the DNA polymerase epsilon 2, accessory subunit (POLE2) in lung cancer cells. Differently expressed genes were profiled in A549 cells incubated in the presence or absence of β‑elemene by Affymetrix Human Gene Expression Array. POLE2 shRNA was then constructed to knock down POLE2 expression. Cells were counted and phenotypes were assessed via CCK‑8, colony formation and caspase-3/-7 activity assays...
August 17, 2018: Oncology Reports
Xiang Pan, Zuwei Li, Liwen Zhao, Jing Quan, Liang Zhou, Jinling Xu, Weiji Xu, Xin Guan, Hang Li, Shangqi Yang, Yaoting Gui, Yongqing Lai
Renal cell carcinoma (RCC) is the third most common urological malignancy in the USA and represents 2‑3% of all adult malignancies. Furthermore, the incidence of RCC has been progressively increasing over recent years. Although the morbidity of treatment has decreased with the use of multidisciplinary synthetic therapy, the prognosis of terminal cancer remains poor, with a 5‑year survival rate of 5‑10%. MicroRNAs (miRs) have been correlated with the regulation of 30‑60% of the protein-coding genes and act as oncogenes or anti‑oncogenes in RCC...
August 17, 2018: Oncology Reports
Huijin Li, Hui Li, Xiao-Peng Li, Haojun Zou, Liting Liu, Wangqiao Liu, Tao Duan
C‑C chemokine receptor type 2 (CCR2) is aberrantly expressed in a variety of tumor cells, and participates in the regulation of tumor cell progression, metastasis and immune escape. However, the mechanism of action of CCR2 in liver cancer remains unclear. In the present study, the aim was to elucidate the molecular mechanism underlying the regulation of epithelial‑to‑mesenchymal transition (EMT) by CCR2 in liver cancer cells. Initially, CCR2 expression in liver cancer tissues was measured, and the survival time of patients was analyzed by Kaplan‑Meier analysis...
August 17, 2018: Oncology Reports
Jian Wu, An-Quan Shang, Chu Chen, Wei-Wei Wang, Cun-Quan Xiong, Nai-Zhou Guo
The aim of the present study was to investigate the mechanisms and protective effect of serum‑free‑medium‑type fetal placental mesenchymal stem cell (fPMSC) culture supernatant on A549 lung epithelial cells following treatment with hydrogen peroxide (H2O2). A549 lung epithelial cells were stimulated with different concentrations of H2O2, and the survival rate of the cells was examined by Cell Counting Kit‑8 (CCK‑8) assay. It was concluded that the H2O2 concentration when the cell survival rate was at 50% was the optimum condition to create an oxidative damage model...
August 17, 2018: Oncology Reports
Jiangdong Xiang, Lina Zhou, Yan Zhuang, Jin Zhang, Ya Sun, Shuangdi Li, Zhenbo Zhang, Gao Zhang, Yinyan He
Lactate, which is regulated by gene expression, is largely believed to favor tumor growth and survival. Elevated lactate dehydrogenase (LDH) is a negative prognostic biomarker because it is a key enzyme involved in cancer metabolism. Our previous study revealed that special AT‑rich‑binding protein 1 (SATB1), a genome‑organizing protein, was strongly associated with high metastasis rates in ovarian cancer. However, its underlying molecular mechanisms in ovarian cancer are unclear. In the present study, we investigated whether SATB1 modulated LDH expression and examined the relationship between SATB1 and LDH in ovarian cancer...
August 17, 2018: Oncology Reports
Hangfan Liu, Jimin Zhao, Yi Yang, Guoguo Jin, Xiaoyan Zhang, Dongyu Wang, Chao Xie, Kangdong Liu, Xinhuan Chen, Xiang Li, Fang Tian, Ziming Dong, Jing Lu
The antitumor effect of the human umbilical vein endothelial cell (HUVEC) vaccine has been well documented; however, its anti‑angiogenic effects on human esophageal squamous cell carcinoma (ESCC) have yet to be studied. In the present study, a 'humanized' mouse model was established by transplanting NOD/SCID mice with human peripheral blood mononuclear cells (PBMC). After 4 weeks, the level of cluster of differentiation (CD)‑45+ human T‑lymphocytes in mouse peripheral blood was >0.1%, which indicated that mouse reconstruction and the human immune system transformation had been successful...
August 17, 2018: Oncology Reports
Yawen Ji, Linglu Jia, Yunpeng Zhang, Yixiao Xing, Xuan Wu, Bin Zhao, Dondjiao Zhang, Xin Xu, Xu Qiao
Morin is a naturally occurring bioflavonoid originally isolated from members of the Moraceae family of flowering plants and it possesses antitumor activity in various human cancer cells. The present study explored the antitumor effects of morin in tongue squamous cell carcinoma (TSCC) cells in vitro and investigated the underlying molecular events. A TSCC cell line was treated with different doses of morin for up to 48 h. Analyses of cell viability, using Cell Counting Kit‑8 (CCK‑8), EdU incorporation, colony formation, flow cytometric analysis of cell cycle distribution and apoptosis, wound healing assay, western blot analysis and qRT‑PCR assays, were then performed...
August 17, 2018: Oncology Reports
Yan-Ming Lu, Yue Wang, Shi-Qi Liu, Meng-Ya Zhou, Ya-Ru Guo
The dysregulation of long non‑coding RNAs (lncRNAs) is associated with cancer development. The present study profiled differentially expressed lncRNAs in ovarian cancer (OC) versus normal ovarian tissues (NT) and investigated their potential functions in gene expression. OC tissues from 30 patients and NT specimens from 20 non‑tumor patients were collected, and 5 cases of tumor and NT were subjected to lncRNA and mRNA microarray analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed...
August 17, 2018: Oncology Reports
Zhi-Li Xu, Yi Zhang, Ling Wang, Feng Li, Hong-Wei Man, Peng-Fei Li, Bao-En Shan
The objective of the present study was to investigate the expression of B7 homologue 3 (B7‑H3) in muscle‑invasive bladder cancer (MIBC) tissues, evaluate its correlation with patient clinicopathological characteristics, and to explore the effect of B7‑H3 on MIBC cells. B7‑H3 expression levels in tumor tissues from 115 patients undergoing radical cystectomy for MIBC were detected by immunohistochemical staining, followed by analysis of the association with clinicopathological characteristics and survival...
August 17, 2018: Oncology Reports
Lu Gao, Wei Zhang, Wen-Qun Zhong, Zhuo-Jue Liu, Hui-Min Li, Zi-Li Yu, Yi-Fang Zhao
The development of head and neck squamous cell carcinoma (HNSCC) is closely associated with inflammation. Tumor associated macrophages (TAMs), the largest population of inflammatory cells in the tumor stroma, serve an important role in accelerating cancer progression. The present study aimed to investigate the role of TAMs in the metastasis of HNSCC. TAM biomarkers and epithelial to mesenchymal transition (EMT)‑associated proteins were detected using immunohistochemical and immunofluorescence staining in HNSCC...
August 17, 2018: Oncology Reports
Baichao Zhang, Xiaoning Yin, Shaoguang Sui
Resveratrol, a natural product, has been revealed to exert antitumor effects in multiple types of tumors. However, the antitumor effects of resveratrol on hepatocellular carcinoma (HCC) and its potential underlying mechanisms have not yet been elucidated. The present study demonstrated that resveratrol inhibited viability, proliferation, invasion and migration of HCC cells significantly in a time‑ and dose‑dependent manner, indicating that resveratrol exerted antitumor effects in HCC. Furthermore, relative expression of autophagy‑related proteins Beclin1 and LC3 II/I ratio was increased while p62 expression was decreased by resveratrol treatment dose‑dependently...
August 17, 2018: Oncology Reports
Hai-Tao Geng, Zhi-Wen Cheng, Rui-Juan Cao, Zhen-Bo Wang, Shao-Zhi Xing, Chen Guo, Feng Wang, Chang-Min Liu, Shao-Shui Chen, Yu-Feng Cheng
The brain expressed x‑linked gene 1 (BEX1) is a member of the BEX family and is aberrantly expressed in many cancers. However, the clinical significance of BEX1 expression level and its role in the pathology of esophageal squamous cell cancer (ESCC) remain unknown. In the present study, we determined BEX1 expression in the tumor and adjacent normal tissues from 118 ESCC patients by immunohistochemistry and determined the proliferation and growth of ESCC cells following ectopic overexpression of BEX1 in cultured cells and in mouse‑ESCC xenografts...
August 17, 2018: Oncology Reports
Wenwen Lv, Xiao Yu, Wenxing Li, Nannan Feng, Tienan Feng, Yu Wang, Hongyan Lin, Biyun Qian
Recently, long non‑coding RNAs (lncRNAs) have been shown to play critical roles in lung adenocarcinoma (LUAD). The present study aimed to explore the effect of LINC00982 and PRDM16 on clinical features and survival in LUAD. We found that LUAD patients demonstrated lower expression and copy number variation but higher methylation of long intergenic non‑protein coding RNA 982 (LINC00982) and PR domain containing 16 (PRDM16) compared with controls. Thus, we divided the LUAD patients into two groups according to the median expression of LINC00982 and PRDM16...
August 14, 2018: Oncology Reports
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