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Oncology Reports

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https://www.readbyqxmd.com/read/30628717/introduction-of-exogenous-wild%C3%A2-type-p53-mediates-the-regulation-of-oncoprotein-18-stathmin-signaling-via-nuclear-factor%C3%A2-%C3%AE%C2%BAb-in-non%C3%A2-small-cell-lung-cancer-nci%C3%A2-h1299-cells
#1
Sangyan Chen, Yan Zhao, Fang Shen, Dan Long, Ting Yu, Xuechi Lin
Our previous studies demonstrated that high expression of oncoprotein 18 (Op18)/stathmin promotes malignant transformation of non‑small cell lung cancer NCI‑H1299 cells. Investigation of the cellular settings determined that NCI‑H1299 cells were genetically p53 deficient. In order to determine whether p53 deficiency is associated with Op18/stathmin‑mediated high levels of malignancy, exogenous wild‑type p53 (p53wt) was introduced into NCI‑H1299 cells in the present study to observe Op18/stathmin signaling changes and malignant behaviors...
January 10, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628714/cthrc1-overexpression-promotes-cervical-carcinoma-progression-by-activating-the-wnt-pcp-signaling-pathway
#2
Mei Zheng, Qin Zhou, Xingguang Liu, Chengze Wang, Gangli Liu
The tumorigenesis and metastasis of tumors are associated with human collagen triple helix repeats containing 1 (CTHRC1). To study the effects and possible impacting mechanisms of CTHRC1 on human cervical carcinoma development, samples of paraffin‑embedded cervical carcinoma and HeLa cells were examined. Immunofluorescence, cell wound scratch assay, western blot analysis and Transwell invasion assay were used to evaluate HeLa cells in response to silencing of the CTHRC1 gene in cervical carcinoma. The expression levels of gap‑associated proteins of the Wnt/PCP pathway in paraffin‑embedded cervical carcinoma samples were also evaluated by immunohistochemical staining...
January 10, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628706/micrornas-and-the-pten-pi3k-akt-pathway-in-gastric-cancer-review
#3
Mingli Hu, Shixuan Zhu, Shengwei Xiong, Xingxing Xue, Xiaodong Zhou
Gastric carcinogenesis arises from complicated interactions among host, environmental and bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor‑suppressive genes. MicroRNAs (miRNAs), a class of small non‑coding RNAs that post‑transcriptionally regulate ~30% human genes, may serve as oncogenes or tumor‑suppressors in malignancies, including gastric cancer (GC). Although miRNA dysregulation commonly exists in GC, exact roles miRNAs serve in the pathogenesis and promotion of this tumor remain undetermined...
January 10, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628699/intravesical-treatment-of-chemotherapeutic-agents-sensitizes-bacillus-calmette%C3%A2-guerin-by-the-modulation-of-the-tumor-immune-environment
#4
Shunta Hori, Makito Miyake, Yoshihiro Tatsumi, Yosuke Morizawa, Yasushi Nakai, Sayuri Onishi, Kenta Onishi, Kota Iida, Daisuke Gotoh, Yoshitaka Itami, Nobumichi Tanaka, Kiyohide Fujimoto
Intravesical treatment with bacillus Calmette‑Guerin (BCG) is the most common treatment for preventing progression and recurrence of non‑muscle invasive bladder cancer. Our previous study using the N‑butyl‑N‑(4‑hydroxybutyl) nitrosamine (BBN)‑induced orthotopic bladder cancer model demonstrated that intravesical treatment with mitomycin C (MMC) and adriamycin (ADM) suppressed pro‑tumoral immunity, including the aggregation of tumor‑associated macrophages (TAMs) and regulatory T cells (Tregs) in the tumor microenvironment...
January 10, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628719/xpc-inhibition-rescues-cisplatin-resistance-via-the-akt-mtor-signaling-pathway-in-a549-ddp-lung-adenocarcinoma-cells
#5
Xue Teng, Xiao-Fan Fan, Qi Li, Shuang Liu, Dong-Yuan Wu, Shu-Ya Wang, Yuanqi Shi, Mei Dong
Xeroderma pigmentosum, complementation group C (XPC) is an accessory recognition gene involved in the nucleotide excision repair (NER) pathway, which is activated during the initial DNA damage recognition stage. It participates in the regulation of DNA damage‑induced proliferation and apoptosis. Emerging evidence demonstrates that upregulation of XPC increases the resistance of several tumor cell types to cytotoxic drugs. In addition, it can predict poor patient outcome for non‑small cell lung cancer (NSCLC)...
January 9, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628716/mir%C3%A2-29a-ameliorates-ischemic-injury-of-astrocytes-in-vitro-by-targeting-the-water-channel-protein-aquaporin-4
#6
Yueying Zheng, Caifei Pan, Manli Chen, Aijie Pei, Liwei Xie, Shengmei Zhu
Ischemic stroke is the main cause of brain injury and results in a high rate of morbidity, disability and mortality. In the present study, we aimed to determine whether miR‑29a played a protective role in oxygen glucose deprivation (OGD) injury via regulation of the water channel protein aquaporin 4 (AQP4). Real‑time PCR and western blotting were used to assess miR‑29a levels and AQP4 protein levels, respectively. Apoptosis was detected by flow cytometry, and lactate dehydrogenase (LDH) was determined by enzyme‑linked immunosorbent assay (ELISA)...
January 9, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628709/electrochemotherapy-of-radioresistant-head-and-neck-squamous-cell-carcinoma-cells-and-tumor-xenografts
#7
Martina Niksic Zakelj, Ajda Prevc, Simona Kranjc, Maja Cemazar, Vesna Todorovic, Monika Savarin, Janez Scancar, Tina Kosjek, Blaz Groselj, Primoz Strojan, Gregor Sersa
Electrochemotherapy is an established local ablative method used for the treatment of different tumor types, including tumors of the head and neck area. Clinical studies have demonstrated a lower response rate of tumors that recur in pre‑irradiated area. The aim of the present study was to explore the response of experimentally induced radioresistant cells and tumors to electrochemotherapy with cisplatin or bleomycin. The radioresistant cells (FaDu‑RR) were established by fractionated irradiation of parental human squamous cell carcinoma cell line, FaDu...
January 9, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628707/anticancer-effects-of-methotrexate-in-combination-with-%C3%AE-%C3%A2-tocopherol-and-%C3%AE-%C3%A2-tocopherol-succinate-on-triple%C3%A2-negative-breast-cancer
#8
Chyou-Wei Wei, Yung-Luen Yu, Yu-Hsun Chen, Yu-Ting Hung, Giou-Teng Yiang
Triple‑negative breast cancers (TNBCs) lack the estrogen receptor, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Therefore, hormone or targeted therapies are not effective in the treatment of TNBC and thus the development of novel therapeutic strategies is crucial. Methotrexate (MTX), a folate antagonist, has been used in the treatment of various types of cancer; however, the anticancer effects of MTX treatment on breast cancer have thus far been ineffective. Vitamin E variants and derivatives have been applied for cancer therapy...
January 9, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628679/cx3cl1-promotes-lung-cancer-cell-migration-and-invasion-via-the-src-focal-adhesion-kinase-signaling-pathway
#9
Wangmi Liu, Yun Liang, Qian Chan, Libo Jiang, Jian Dong
The present study investigated the role of C‑X3‑C motif chemokine ligand 1 (CX3CL1) in lung cancer cell migration and invasion and its potential mechanism. The expression levels of C‑X3‑C motif chemokine receptor 1 (CX3CR1) in six human lung cancer cell lines and one human bronchial epithelial cell line were assessed using reverse transcription‑quantitative polymerase chain reaction and western blotting. Cell proliferation was assessed using the Cell Counting Kit‑8 assay. Cell migration and invasion were examined using the Transwell assay, with and without Matrigel, respectively...
January 9, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628704/ubiquitination%C3%A2-deubiquitination-in-the-hippo-signaling-pathway-review
#10
Yanting Liu, Jun Deng
The Hippo signaling pathway is considered to be a tissue growth regulator and tumor suppressor pathway that controls cell proliferation, differentiation, survival, regeneration and tissue homeostasis. Defects in Hippo kinases and hyperactivation of transcriptional co‑activator with PDZ‑binding motif and Yes‑associated protein (YAP) may contribute to the development of different types of cancer. The Hippo pathway is regulated in a variety of way, of which ubiquitination is of considerable importance. Ubiquitination is a crucial post‑translational protein modification in cancer cells and is an applicable target for pharmacological intervention...
January 8, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628705/-corrigendum-oncogenic-function-of-plac1-on-the-proliferation-and-metastasis-in-hepatocellular-carcinoma-cells
#11
Yuan Wu, Xiaocong Lin, Xiaoqing Di, Yonghua Chen, Hanning Zhao, Xin Wang
Following the publication of this article, the authors have realized that Table I contained some important errors. The data shown for the positive or negative HBsAg patient characteristic in terms of the no. of patients, Plac1 (+) and Plac1 (‑) were incorrect. A corrected version of the Table is shown below (the corrected data are highlighted in bold). The authors sincerely apologize for the errors that were introduced during the preparation of this Table. Furthermore, they regret any inconvenience that this mistake has caused...
January 4, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628708/identification-of-prognostic-biomarkers-for-patients-with-hepatocellular-carcinoma-after-hepatectomy
#12
Xiangkun Wang, Xiwen Liao, Chengkun Yang, Ketuan Huang, Tingdong Yu, Long Yu, Chuangye Han, Guangzhi Zhu, Xianmin Zeng, Zhengqian Liu, Xin Zhou, Wei Qin, Hao Su, Xinping Ye, Tao Peng
Hepatocellular carcinoma (HCC) is a lethal malignancy with high morbidity and mortality rates worldwide. The identification of prognosis‑associated biomarkers is crucial to improve HCC patient survival. The present study aimed to explore potential predictive biomarkers for HCC. Differentially expressed genes (DEGs) were analyzed in the GSE36376 dataset using GEO2R. Hub genes were identified and further investigated for prognostic value in HCC patients. A risk score model and nomogram were constructed to predict HCC prognosis using the prognosis‑associated genes and clinical factors...
January 3, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30628703/effect-of-nell1-on-lung-cancer-stem%C3%A2-like-cell-differentiation
#13
Yuanfen Zhai, Rongbin Wei, Shuang Sha, Chengzhao Lin, Heyong Wang, Xinquan Jiang, Gentao Liu
The cancer stem cell theory recently has received enormous attention in cancer biology. Lung cancer stem‑like cells are a subpopulation of undifferentiated lung tumor cells critical for lung cancer tumorigenesis, metastasis and resistance to therapy and disease relapse. The neural EGFL like 1 (NELL1) is a potent growth factor believed to preferentially target cells committed to the osteochondral lineage; yet, its expression and function in lung cancer are largely unknown. In the present study, we used specific medium to accumulate lung cancer stem‑like cells of 95‑D cells in spheres and obtained these highly expressed CD133 cells through flow cytometric cell sorting of CD133‑stained cells which were termed 95‑D lung cancer stem‑like cells (95‑D LCSCs)...
January 3, 2019: Oncology Reports
https://www.readbyqxmd.com/read/30592293/bromodomain%C3%A2-containing-protein-7-sensitizes-breast-cancer-cells-to-paclitaxel-by-activating-bcl2%C3%A2-antagonist-killer-protein
#14
Jinqi Ma, Weihong Niu, Xinye Wang, Yao Zhou, Heran Wang, Fengxia Liu, Yukun Liu, Jie Guo, Wei Xiong, Zhaoyang Zeng, Songqing Fan, Xiaoling Li, Xinmin Nie, Guiyuan Li, Rong Gui, Yanwei Luo, Ming Zhou
Our previous study demonstrated that bromodomain‑containing protein 7 (BRD7) inhibits cell proliferation and tumor growth, restoring the expression of B‑cell lymphoma 2 antagonist/killer (Bak) sensitized breast cancer cells to paclitaxel. However, the association between BRD7 and paclitaxel sensitization, as well as BRD7 and Bak in breast cancer remains unknown. In the present study, immunochemical staining was performed to measure the expression of BRD7 and Bak in breast cancer tissues. Cell Counting Kit‑8 assay, flow cytometry and tumor xenograft procedures were performed to evaluate the biological role of BRD7 and Bak in breast cancer cells...
December 21, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30592292/cytoplasmic-m%C3%A2-csf-facilitates-apoptosis-resistance-by-inhibiting-the-hif%C3%A2-1%C3%AE-bnip3-bax-signalling-pathway-in-mcf%C3%A2-7-cells
#15
Mengxia Zhang, Qi Liu, Lijun Li, Jing Ning, Jian Tu, Xiaoyong Lei, Zhongcheng Mo, Shengsong Tang
Macrophage colony‑stimulating factor (M‑CSF), a tumour marker, is related to tumour cell anti‑apoptosis and drug resistance. However, the role of M‑CSF in MCF‑7 cells is unknown. In the present study, the effect and mechanism of M‑CSF on hypoxia‑inducible factor‑1α (HIF‑1α)/BCL2/adenovirus E1B 19 kDa‑interacting protein 3 (BNIP3)/Apoptosis Regulator BAX signalling in human breast cancer MCF‑7 cells were investigated. Western blotting revealed that the expression of HIF‑1α, BNIP3, Bax, caspase‑3 and caspase‑9 was lower in MCF‑7‑M cells compared to MCF‑7 and MCF‑7‑C cells treated with adriamycin (ADM)...
December 21, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30592290/shcbp1-is-a-novel-target-and-exhibits-tumor%C3%A2-promoting-effects-in-gastric-cancer
#16
Ya-Dong Dong, Yan-Li Yuan, Hai-Bo Yu, Guang-Jin Tian, De-Yu Li
The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in GC tissues. Furthermore, SHCBP1 was revealed to be highly expressed in GC cell lines MGC‑803 and SGC‑7901 cells, and downregulation of SHCBP1 significantly inhibited GC cell proliferation...
December 21, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30592289/integrating-modern-approaches-to-pathogenetic-concepts-of-malignant-transformation-of-endometriosis
#17
Hiroshi Kobayashi, Yuki Yamada, Naoki Kawahara, Kenji Ogawa, Chiharu Yoshimoto
In the present study, we summarize the role of the shared and independent (epi)genetic background between endometrioid carcinoma (EC) and clear cell carcinoma (CCC), two histological subtypes of endometriosis-associated ovarian cancer (EAOC). Using the PubMed database, we conducted a literature review of various studies related to the malignant transformation of endometriosis. Both endometriosis and EAOC face potential environmental hazards, including hemoglobin (Hb), heme and free iron, which induces DNA damage and mutations...
December 21, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30592286/mir%C3%A2-498-inhibits-the-growth-and-metastasis-of-liver-cancer-by-targeting-zeb2
#18
Xu Zhang, Xueying Xu, Guohong Ge, Xueyan Zang, Meng Shao, Shengqiang Zou, Yu Zhang, Zheying Mao, Jiayin Zhang, Fei Mao, Hui Qian, Wenrong Xu
MicroRNAs (miRNAs) play critical roles in the growth, metastasis and therapeutic resistance of liver cancer. Accumulating evidence suggests that miR‑498 is aberrantly expressed in several human malignancies. However, the role and underlying mechanism of miR‑498 in liver cancer remain unclear. In the present study, we investigated the potential roles and clinical value of miR‑498 in liver cancer. We found that the miR‑498 expression level was significantly lower in liver cancer patient tissues than that in healthy control tissues...
December 21, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30592285/gambogenic-acid-inhibits-the-proliferation-of-small%C3%A2-cell-lung-cancer-cells-by-arresting-the-cell-cycle-and-inducing-apoptosis
#19
Tingting Huang, Hongming Zhang, Xiyong Wang, Lu Xu, Jinfang Jia, Xiaoli Zhu
Gambogenic acid (GNA), which is an important active compound present in gamboge, exerts anticancer activity in various types of tumor cells. However, the effect of GNA on small‑cell lung cancer (SCLC) cell lines and the underlying mechanism involved still remain unclear. In the present study, GNA inhibited the proliferation and cell cycle progression of SCLC cells. GNA also promoted the apoptosis of SCLC cells in a dose‑dependent manner, which is associated with modulating the levels of proteins involved in apoptosis pathways in NCI‑H446 and NCI‑H1688 cells...
December 21, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30592283/identification-and-validation-of-alternative-splicing-isoforms-as-novel-biomarker-candidates-in-hepatocellular-carcinoma
#20
Peng Wu, Donghu Zhou, Yuqian Wang, Weiran Lin, Aihua Sun, Handong Wei, Yi Fang, Xianling Cong, Ying Jiang
Alternative splicing (AS) is a transcriptional regulation mechanism that participates in multiple aspects of cancer. The present study aimed to identify differential AS events from tumor and non‑tumor samples and investigate the potential of AS as a source of candidate cancer diagnostic biomarkers. Deep RNA sequencing of three paired hepatocellular carcinoma (HCC) tumors and adjacent non‑tumors was applied to identify AS events. RT‑qPCR was performed on 45 HCC clinical samples to validate the splicing differences...
December 21, 2018: Oncology Reports
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