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Journals Revista de Investigación Cl...

Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición

https://read.qxmd.com/read/38154125/continuous-renal-replacement-therapy-what-have-we-learned-and-what-are-key-milestones-for-the-years-to-come
#21
JOURNAL ARTICLE
Pablo Galindo, Javier A Neyra
Continuous renal replacement therapy (CRRT) is the main extracorporeal kidney support therapy used in critical ill patients in the intensive care unit (ICU). Since its conceptualization ~50 years ago, there have been major improvements in its technology and utilization. The last decade, and particularly since the COVID-19 pandemic, has been marked by a growing interest and demand of CRRT in worldwide ICUs. This has underpinned the need for improvements in nomenclature and process standardization, optimization of CRRT deliverables, and the development and validation of key performance indicators...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38147578/preface-advances-in-dialysis-in-the-last-decade
#22
JOURNAL ARTICLE
Olynka Vega-Vega, Noemí Del Toro-Cisneros
No abstract text is available yet for this article.
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918014/tumor-promoting-effects-of-microrna-421-4-aminobutyrate-aminotransferase-axis-in-hepatocellular-carcinoma
#23
JOURNAL ARTICLE
Yuanguang Liu, Ran Cheng, Yijie Wu, Chunmei Liu, Yang Liu, Qing Chang, Jun Yin
Background: MicroRNA-421 (miR-421) has been implicated in hepatocellular carcinoma (HCC), but its potential mechanism in HCC remains unclear. Objectives: The study aimed to study the potential mechanism of miR-421 in HCC which is necessary. Methods: The downstream target genes of miR-421 were screened in HCC tissues and cells using miDIP, Targetscan, and starBase databases. Differential analysis, survival analysis, and Pearson correlation analysis were performed between miR-421 and its downstream target genes...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918013/multivariate-prognostic-models-for-patients-with-stages-i-and-ii-colon-carcinoma-a-strobe-compliant-retrospective-cohort-study
#24
RANDOMIZED CONTROLLED TRIAL
Luis F Oñate-Ocaña, Roberto Herrera-Goepfert, Alejandro Avilés-Salas, Carlo C Cortés, Sagrario González-Trejo, José F Carrillo, Erika Ruiz-García, Francisco J Ochoa-Carrillo, Vincenzo Aiello-Crocifoglio, Claudia M García-Cuellar
Background: Colorectal cancer is the most frequent gastrointestinal malignancy worldwide. The value of adjuvant treatment is controversial in Stages I and II. Objective: The aim of this study was to construct post-operative prognostic models applicable to patients with stages I-II colon carcinoma (CC). Methods: This is a retrospective cohort study of patients with Stage I-II CC treated over a 25-year period. Exposure was defined as clinical, histopathological, and immunohistochemical factors (including CDX2 and MUC2 expression)...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918012/predictive-performance-of-triglyceride-glucose-index-on-asymptomatic-multiple-organ-damage-in-patients-with-newly-diagnosed-hypertension
#25
JOURNAL ARTICLE
Ahmet Kivrak, Alp Yildirim
Background: Insulin resistance (IR) contributes to the development of hypertension and mediated organ damage (HMOD) through various mechanisms. Objectives: The objective of the study was to assess the diagnostic performance of the triglyceride-glucose (TyG) index, a surrogate marker of IR, in predicting the presence and severity of HMOD in newly diagnosed untreated hypertensive patients from an academic training and research hospital. Methods: The study included 438 patients with newly diagnosed, untreated hypertension...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37918011/anti-hla-donor-specific-antibodies-are-associated-to-infection-and-not-to-the-engraftment-rate-in-outpatient-haploidentical-hematopoietic-cell-transplantation
#26
JOURNAL ARTICLE
José C Jaime-Pérez, María L Ruiz-De La Cruz, Sandra I Mendoza-Ibarra, Nidia K Moncada-Saucedo, David Gómez-Almaguer
Background: Recipients of a related haploidentical stem cell transplant (haplo-SCT) can have preformed antibodies to HLA donor's antigens. Objective: The aim of the study was to evaluate the engraftment rate and major clinical associations of anti-HLA donor-specific antibodies (DSA) at two mean fluorescence intensity (MFI) thresholds in recipients of an outpatient haplo-SCT. Methods: Seventy haplo-HCT recipients were analyzed. A virtual crossmatch was performed using the donor HLA typing and the recipient's anti-HLA DSA test results...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37607036/type-2-diabetes-mellitus-and-nonvalvular-atrial-fibrillation-in-mexico-national-registries-raise-a-red-flag
#27
JOURNAL ARTICLE
Manlio F Márquez-Murillo, Eduardo Brenner-Muslera, Diana L Rodríguez-Carrillo, César A Chua-López, Margarita Torres-Tamayo
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide and is highly prevalent in Mexico, as 10.2% of the adult population harbors this condition. T2DM is usually associated with cardiovascular comorbidities, including arrhythmias. Metabolic impairment is one of the mechanisms that contribute to tissue remodeling that affects atrial structure, and concomitant, the cardiac conduction system, both could result in atrial fibrillation (AF). AF is estimated to affect more than a half million Mexicans, and its incidence is expected to keep rising...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37607031/meta-analysis-to-implement-alpha-synuclein-in-extracellular-vesicles-as-a-potential-biomarker-for-parkinsons-disease
#28
JOURNAL ARTICLE
Víctor H Juárez-Vaquera, Marcos F Rosetti-Sciutto, Valeria Morales-Ruiz, Laura V Adalid-Peralta
Background: In Parkinson's disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker. Objective: Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency. Methods: Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis. Results: Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37607027/new-onset-geriatric-epilepsy-in-a-latin-american-country-a-multi-centric-study-from-mexico
#29
JOURNAL ARTICLE
Roberto A Suástegui Román, Ángel Lee, Laura E Hernández Vanegas, Gerónimo Pacheco-Aispuro, Brigham Bowles, Christopher Mader, Elizabeth Aveleyra Ojeda
Background: In Latin America, epilepsy in the elderly is a neglected issue that has never been studied. The epidemiological transition has significantly altered the demographics of epilepsy, and therefore, we would like to draw attention to this topic. Objective: We require local real-world evidence, as the literature often depicts a different scenario, including pharmacological management. Methods: From 2007 to 2018, we recruited all patients with new-onset geriatric epilepsy (first seizure after the age of 60) tracked from ten Mexican hospitals, adding them to patients with similar characteristics from a previously published study...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37603449/the-predictive-value-of-r-wave-peak-time-to-detect-thrombus-burden-in-st-segment-elevation-myocardial-infarction-a-retrospective-cohort-study-in-a-tertiary-medical-center
#30
JOURNAL ARTICLE
Zehra Güven-Çetin, Bekir Demirtaş, Ahmet Balun, Hülya Çiçekçioğlu, Kerem Özbek, Mustafa Çetin
Background: Patients with higher thrombus burden have higher procedural complications and more long-term adverse cardiac events. Detecting patients with high thrombus burden (HTB) before coronary intervention could help avoid procedural complications. Objective: The research aimed to analyze the R wave peak time (RWPT) on the electrocardiogram to predict thrombus burden before coronary angiography in patients with acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods: A total of 159 patients with STEMI were included in the study conducted at a tertiary medical center...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441771/fentanyl-and-other-new-psychoactive-synthetic-opioids-challenges-to-prevention-and-treatment
#31
JOURNAL ARTICLE
Damaris Albores-García, Silvia L Cruz
Synthetic opioids have played a significant role in the current opioid crisis in the United States (U.S.) and Canada and are a matter of concern worldwide. New psychoactive opioids (NPOs) are classified in the internationally recognized new psychoactive substances (NPSs) category. This group comprises compounds that may have been synthesized decades ago but appeared only recently in the illicit drug market. Such is the case of fentanyl, fentanyl analogs, and non-fentanyl opioids. Most NPOs have effects similar to morphine, including euphoria and analgesia, and can produce fatal respiratory depression...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441770/amphetamine-type-stimulants-novel-insights-into-their-actions-and-use-patterns
#32
REVIEW
Miguel I Paz-Ramos, Silvia L Cruz, Valeria Violante-Soria
This review focuses on the effects and mechanisms of action of amphetamine-type stimulants (ATS) and their adverse effects on the cardiovascular, nervous, and immune systems. ATS include amphetamine (AMPH), methamphetamine (METH, "crystalmeth," or "ice"), methylenedioxymethamphetamine (MDMA, "ecstasy," or "Molly"), MDMA derivatives (e.g., methylenedioxyamphetamine [MDA] and methylenedioxy-N-ethylamphetamine [MDEA]), khat, and synthetic cathinones. The first section of this paper presents an overview of the historical aspects of ATS use, their initial clinical use, and regulations...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441767/preface-special-issue-on-challenges-and-new-findings-on-misused-psychoactive-drugs
#33
JOURNAL ARTICLE
Silvia L Cruz
No abstract text is available yet for this article.
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441766/-cannabis-drug-of-abuse-and-therapeutic-agent-two-sides-of-the-same-coin
#34
JOURNAL ARTICLE
Ana Canseco-Alba, Gabriela Rodríguez-Manzo
The consumption of Cannabis sativa plant, known as marijuana in the Western world, for different purposes (therapeutic, intoxicating, and spiritual) due to its psychoactive effects, can be traced back to ancient times. Cannabis is the most used illicit drug worldwide; however, its legal status is changing rapidly. Cannabis regulation will allow a better understanding of its effects as a misused drug, including new challenges, such as the availability of highly potent Cannabis extracts . Furthermore, scientific research is making significant efforts to take advantage of the potential therapeutic uses of Cannabis active compounds...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441764/alcohol-immunomodulatory-effects-and-cancer
#35
JOURNAL ARTICLE
Juan C Molina, Jesús D Guerrero-Morán, Claudia González-Espinosa
Alcohol consumption has been linked to numerous pathologic conditions, including infectious diseases and several types of cancer. Alcohol exerts its modulatory effects on the immune system (IS) in a dose- and time-dependent manner. Numerous studies indicate that these alterations affect responses such as peripheral inflammation or decreased antibody production and promote chronic inflammation, leading to cell death. The molecular mechanisms underlying these effects involve generating an oxidative tissue environment, producing cell damage-associated molecular patterns (DAMPs), and activating pattern recognition receptors...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441761/the-resurgence-of-hallucinogen-drugs-in-clinical-research
#36
REVIEW
María T Rivera-García, Silvia L Cruz
Since the dawn of civilization, ancient cultures have utilized hallucinogens from plants and fungi in the context of religious and healing practices. Recently, their use has expanded to other cultures. Hallucinogens are natural or synthetic substances that alter the perception of reality at nontoxic doses, producing intense psychological and physiological effects. The initial research on hallucinogens began in the 1950s. However, their non-medical use, studies without proper controls, and negative social opinion resulted in legal restrictions that limited their use for clinical and preclinical research for more than two decades...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/37441760/addiction-to-tobacco-smoking-and-vaping
#37
JOURNAL ARTICLE
Andrea Hernández-Pérez, Leonor García-Gómez, Robinson Robles-Hernández, Ireri Thirión-Romero, Jennifer Osio-Echánove, Sebastián Rodríguez-Llamazares, Ruben Baler, Rogelio Pérez-Padilla
The tobacco epidemic has been one of the biggest public health threats, and smoking is one of the world's largest preventable causes of premature death. An estimated 15.4% of all deaths in the world are attributable to tobacco smoking. The present review aims to describe addiction to tobacco smoking and vaping. Tobacco and vaping devices contain nicotine, a highly addictive drug, which explains why smoking is so prevalent and persistent. Electronic cigarettes are a group of novel nicotine or tobacco products that have rapidly gained popularity in recent years...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/36854079/molecular-and-genetic-mechanisms-of-neurotoxicity-during-anti-seizure-medications-use
#38
JOURNAL ARTICLE
Carmen Rubio, Fernando Gatica, Eric Uribe, Ernesto Ochoa, Victoria Campos, Moisés Rubio-Osornio
Epilepsy is a multifactorial pathology that has allowed the development of various drugs aiming to combat it. This effort was formally initiated in the 1940s when phenytoin began to be used. It eventually turned out to be a drug with great anticonvulsant efficacy. At present, several potentially good new generation anti-seizure medications (ASMs) have been developed. Most of them present more tolerability and less toxic effects. However, they continue to have adverse effects at different levels. In addition, some seizures are difficult to treat with ASMs, representing 30% of the total cases of people who suffer from epilepsy...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/36854075/arterial-blood-gases-in-normal-subjects-at-2240-meters-above-sea-level-impact-of-age-gender-and-body-mass-index
#39
JOURNAL ARTICLE
Silvia Cid-Juárez, Norma A Téllez-Navarrete, Anaid Bautista-Bernal, Pablo León-Gómez, Isabel Salas-Escamilla, Laura Gochicoa-Rangel, Rogelio Pérez-Padilla
BACKGROUND: The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population's adaptation. OBJECTIVE: The aim of the study was to describe ABG in a healthy population residing at 2,240 meters above sea level, to identify the mean level of alveolar ventilation (PaCO2 ), and to know whether a progressive increase in PaCO2 occurs with age and the impact of increasing body mass index (BMI)...
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/36854074/at-risk-pregnant-woman-with-sticky-platelet-syndrome-previous-recurrent-preeclampsia-and-current-proteinuria-a-rare-experience
#40
JOURNAL ARTICLE
Lucia Stančiaková, Miroslava Dobrotová, Jela Ivanková, Ingrid Škorňová, Tomáš Bolek, Monika Brunclíková, Matej Samoš, Ján Danko, Mária Škereňová, Peter Kubisz, Ján Staško
No abstract text is available yet for this article.
2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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