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Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición

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https://www.readbyqxmd.com/read/29718013/ketamine-for-treatment-resistant-depression-a-new-advocate
#1
Rodrigo Pérez-Esparza
Current alternatives for the treatment of major depressive disorder lack efficacy and have a delayed onset of action. Recently, the glutamatergic neurotransmission system has been noted to play an important role in the pathophysiology of this disorder. Ever since the first report of the antidepressant effects of the N-methyl-D-aspartate receptor antagonist, ketamine, research has been redirected to novel therapeutic targets. With this rapidly growing evidence of a fast-acting antidepressant such as ketamine, as well as its efficacy in treatment-resistant cases of depression, off-label use has become popular in certain settings...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29718012/schwann-cell-precursor-transplant-in-a-rat-spinal-cord-injury-model
#2
Oscar de la Garza-Castro, Herminia Guadalupe Martínez-Rodríguez, Sandra Gabriela Sánchez-González, Oscar Vidal-Torres, Azalea Arreola-Romero, Oscar de la Garza-Pineda, Adriana Guadalupe Ancer-Arellano, Santos Guzmán-López, Rodrigo Enrique Elizondo-Omaña
Background: Differentiation of mesenchymal stem cells into Schwann cell precursors could reverse established lesions and sequelae of medullary transection. Objective: The objective of this study was to study the clinical response of mesenchymal stem cell transplantation with Schwann precursor cell transplantation in a rat spinal cord injury model, using motor function and histopathologic studies. Materials and Methods: A total of 28 Sprague-Dawley rats were randomly divided among four groups (n = 7 in each): sham group, control group, mesenchymal stem cell transplant group, and Schwann cell precursor transplant group...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29718011/association-of-intron-2-variable-numbers-of-an-86-bp-tandem-repeat-polymorphisms-of-interleukin-1-receptor-antagonist-gene-and-idiopathic-recurrent-spontaneous-abortion
#3
Marco Antonio Avila-Vergara, Felipe de Jesús Peraza-Garay, Noemí Meraz-Cruz, Cesar Hernandez-Guerrero, Berenice Palacios-Gonzalez, Felipe Vadillo-Ortega
Background: It has been proposed that abnormal modulation of inflammatory response is involved in the physiopathology of idiopathic recurrent spontaneous abortion (iRSA). Factors that may participate in this process include the genetic background such as carrying specific polymorphisms of genes with functional effects. Objective: The objective is to study the association between iRSA and the frequency of intron-2 variable number tandem repeat-polymorphisms of interleukin-1 receptor antagonist gene (IL1RN)...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29718010/phenotypic-variability-in-a-mexican-mestizo-family-with-retinal-vasculopathy-with-cerebral-leukodystrophy-and-trex1-mutation-p-v235gfs-6
#4
Nancy Monroy-Jaramillo, Aurelio Cerón, Elizabeth León, Verónica Rivas, Adriana Ochoa-Morales, María Georgina Arteaga-Alcaraz, Fausto Carlos Nocedal-Rustrian, Cecilia Gallegos, María Elisa Alonso-Vilatela, Teresa Corona, José Flores
Background: Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an adult-onset, autosomal dominant disease involving microvessels of the brain and eye resulting in central nervous system degeneration with visual disturbances, stroke, motor impairment, and cognitive decline. Frameshift mutations at the C-terminus of TREX1 gene are the molecular cause of this disorder. Objectives: The objective of this study is to present the different clinical manifestations of RVCL in three-related patients and to investigate the presence of TREX1 mutation in the extended genealogy...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29718009/pulmonary-vasoreactivity-and-phenotypes-in-pulmonary-arterial-hypertension-associated-to-connective-tissue-diseases
#5
José Luis Hernández-Oropeza, Tatiana Sofía Rodríguez-Reyna, Diego Luis Carrillo-Pérez, José de Jesús Rodríguez-Andoney, René Narváez-David, Yesenia Salado-Morales, Eduardo Rivero-Sigarroa, Guillermo Domínguez-Cherit, Tomás Pulido-Zamudio
Background: Pulmonary arterial hypertension (PAH) is a fatal complication in patients with connective tissue disease (CTD). Objective: The objective of the study was to study the prognostic value of the acute pulmonary vasoreactivity test with inhaled iloprost and its association with clinical deterioration in a tertiary care academic medical center. Methods: We conducted a prospective study of patients with CTD and the diagnosis of PAH established by right heart catheterization...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29718008/correlation-between-lung-and-joint-involvement-in-patients-with-rheumatoid-arthritis-and-interstitial-lung-disease-a-cross-sectional-study
#6
Francisco Paulin, Juan Francisco Mercado, Martín Eduardo Fernández, Fabián Matías Caro, María Laura Alberti, Leandro Alberto Fassola
Background: Rheumatoid arthritis (RA) can affect the lungs in different manners, with interstitial lung disease (ILD) as the most serious manifestation. Although lung and joint compromise could be thought to evolve in parallel, there are data suggesting the opposite. In this study, we evaluated the relationship between lung and joint involvement in RA ILD. Methods: An observational cross-sectional study of RA ILD patients evaluated from January 2015 to February 2017...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29513304/a-prognostic-score-for-survival-in-patients-older-than-65-years-with-diffuse-large-b-cell-lymphoma
#7
Myrna Candelaria, Nancy Reynoso-Noverón, Mayra Ponce, Rodrigo Castillo-Llanos, Diana Nolasco-Medina, David Cantú-De-Leon
Background: Available prognosis scores for patients with diffuse large B-cell lymphoma (DLBCL) included a limited number of patients ≥ 65 years of age, and most of them did not include comorbidities. Here, we propose a prognostic score for overall survival (OS) for this group of patients. Materials and Methods: Patients ≥ 65 years with DLBCL treated at a single national reference center were included. Clinical features including comorbidities and biochemical parameters were analyzed...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29513303/chewing-xylitol-gum-could-accelerate-bowel-motility-recovery-after-elective-open-proctectomy-for-rectal-cancer
#8
Ping Yang, Wu Jun Long, Li Wei
Background: A number of studies with conflicting results have evaluated the effect of chewing gum on post-operative gastrointestinal recovery in patients after major colorectal surgery. Objective: The objective of the study was to study the efficacy of chewing gum in patients with rectal cancer after elective open proctectomy only. Methods: A randomized controlled clinical trial was performed. We recruited patients who would undergo elective open proctectomy for rectal cancer in Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29513302/innate-immunity-in-coronary-disease-the-role-of-interleukin-12-cytokine-family-in-atherosclerosis
#9
Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón
Atherosclerosis is a chronic, progressive, and multifactorial disease modulated by genetic and environmental factors. In recent years, the paradigm that explained atherosclerosis as resulting from a complex interaction between factors not accessible to medical intervention, and modifiable risk factors has changed. In this paradigm, alterations in lipid metabolism were the pivotal concept of atherosclerosis as a chronic degenerative disease. In the last years, an increasing number of observations have shown that the innate and adaptive immune responses to lipoprotein deposition and oxidation in the arterial wall significantly influence atherosclerosis...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29513301/changing-trends-in-gastric-polyps
#10
Magali Evangelina Velázquez-Dohorn, Carlos Fernando López-Durand, Armando Gamboa-Domínguez
Background: The prevalence of gastric polyps varies around the world reflecting regional associations. We describe demographic features of patients with gastric polyp diagnosis treated between 1980 and 2016 at a referral center in Mexico City and analyzed trends of polyp subtype. Materials and Methods: We conducted a blind review of archival slides of gastric biopsies with polyp diagnosis from the years 1980, 1990, 2000, 2010, and 2016. Initial diagnosis; patient's gender, age and symptoms; and number and location of lesions were recorded...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29513300/heading-toward-the-elimination-of-hepatitis-c-virus
#11
David Kershenobich, Aldo Torre-Delgadillo, Luz María Aguilar-Valenzuela
Chronic hepatitis C is often asymptomatic and may progress over the years to cirrhosis and hepatocellular carcinoma. Although the prevalence and incident cases are decreasing, the peak mortality of hepatitis C virus (HCV)-related complications is ahead of us in most countries. The economic impact of this burden is enormous. Scaling up the identification of new opportunities to facilitate the road toward HCV elimination includes increasing screening, awareness, and the number of prescribing physicians. Screening should occur within the context of linkage-to-care and patient retention across the care continuum...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29513299/cytotoxic-activity-of-a-black-bean-phaseolus-vulgaris-l-extract-and-its-flavonoid-fraction-in-both-in-vitro-and-in-vivo-models-of-lymphoma
#12
Ulises Aregueta-Robles, Oscar R Fajardo-Ramírez, Luis Villela, Janet A Gutiérrez-Uribe, José Hernández-Hernández, Rosa Del Carmen López-Sánchez, Sean-Patrick Scott, Sergio Serna-Saldívar
Background: Black bean (Phaseolus vulgaris L.) is a very common legume seed in Mexican diet. Flavonoids and crude extracts from different plants have been reported as effective agents for chemoprevention and cytotoxicity in several cancer cell lines. We investigated the effects of black bean hulls extract (BBE) and its flavonoid fraction (FF) on lymphoma cells. Methods: BBE and FF were characterized by high-performance liquid chromatography. Viability and flow cytometry assays were carried out...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29513298/nod2-activation-during-bacterial-and-viral-infections-polymorphisms-and-potential-as-therapeutic-target
#13
Diana Alhelí Domínguez-Martínez, Daniel Núñez-Avellaneda, Carlos Alberto Castañón-Sánchez, Ma Isabel Salazar
Nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptors or NLRs are a family of receptors that detect both, molecules associated to pathogens and alarmins, and are located mainly in the cytoplasm. NOD2 belongs to the NLR family and is a dynamic receptor capable of interacting with multiple proteins and modulate immune responses in a stimuli-dependent manner. The experimental evidence shows that interaction between NOD2 structural domains and the effector proteins shape the overall response against bacterial or viral infections...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265118/two-hundred-years-later-is-parkinson-s-disease-a-single-defined-entity
#14
Mayela Rodríguez-Violante, Amin Cervantes-Arriaga, Stanley Fahn, Eduardo Tolosa
An Essay on the Shaking Palsy, by James Parkinson, was published in 1817. Later, Jean-Martin Charcot better described some of the motor features of the disease and named the condition as "La Maladie de Parkinson." As understanding about the disease progressed, aided by both clinical expertise and technological developments, the definition of what is Parkinson's disease has evolved. Motor phenotype, non-motor symptoms, monogenic mutations, genetic risk factors, disease subtyping, and data-driven clusters, among other concepts, have given rise to the hypothesis that Parkinson's disease may be not one well-defined entity but several different diseases encompassed as a levodopa-responsive Parkinsonism...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265117/dose-volume-effect-of-acute-diarrhea-in-post-operative-radiation-for-gynecologic-cancer
#15
Qian Li, Jing Chen, Biqing Zhu, Minghua Jiang, Wei Liu, Emei Lu, Qiao-Ling Liu
Background: Diarrhea is the primary symptom of concern in acute post-operative radiation-induced enteritis in gynecologic cancer. We retrospectively studied the correlation between the volume of irradiated small bowel and the development of acute diarrhea in these patients. Materials and Methods: A total of 100 post-operative gynecologic cancer patients were analyzed. Pelvic computed tomography was performed to calculate the volume of irradiated small bowel. A dose-volume histogram was calculated from 5 to 40 Gy at 5 Gy intervals...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265116/abnormal-cardiovascular-findings-in-acute-pancreatitis-are-they-associated-with-disease-severity
#16
Martin A Chacón-Portillo, Gerardo Payró-Ramírez, Mario C Peláez-Luna, Luis F Uscanga-Domínguez, Zuilma Vasquéz-Ortiz, Consuelo Orihuela, Sophia E Martínez-Vázquez, Jorge Hernández-Calleros
Background: Acute pancreatitis (AP), a disease that commonly requires in-hospital treatment, has been associated with a high incidence of abnormal cardiovascular findings (ACFs). We conducted a prospective study to explore the association of these findings with severity of the disease. Methods: Adult patients with AP diagnosis were prospectively enrolled in an observational study during an 8-month period in a tertiary care center. AP and its severity were defined according to the Revised Atlanta Classification of AP...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265115/chikungunya-molecular-aspects-clinical-outcomes-and-pathogenesis
#17
Eduardo Bautista-Reyes, Daniel Núñez-Avellaneda, Luis Antonio Alonso-Palomares, Ma Isabel Salazar
The alarming worldwide emergence of the chikungunya virus began in the last decade. Since the first autochthonous transmission in Mexico in November of 2014, the virus has spread throughout the country, resulted in multiple outbreaks. This virus produces an acute and self-limiting disease characterized by fever, polyarthralgia, myalgia, exanthema, and general malaise. It is transmitted to humans by the bite of Aedes aegypti and A. albopictus mosquitoes. The fact that the clinical presentation is similar to that produced by other arboviruses complicates its clinical diagnosis...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265114/distinguishing-intracerebral-hemorrhage-from-acute-cerebral-infarction-through-metabolomics
#18
Xuxin Zhang, Yanzhao Li, Yan Liang, Pitong Sun, Xue Wu, Jinhui Song, Xiaoyu Sun, Mo Hong, Peng Gao, Dongfeng Deng
Background: Acute cerebral infarction (ACI) and intracerebral hemorrhage (ICH) are potentially lethal cerebrovascular diseases that seriously impact public health. ACI and ICH share several common clinical manifestations but have totally divergent therapeutic strategies. A poor diagnosis can affect stroke treatment. Objective: To screen for biomarkers to differentiate ICH from ACI, we enrolled 129 ACI and 128 ICH patients and 65 healthy individuals as controls. Methods: Patients with stroke were diagnosed by computed tomography/magnetic resonance imaging, and their blood samples were obtained by fingertip puncture within 2-12 h after stroke initiation...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265113/rates-of-surgical-site-infection-in-cholecystectomy-comparison-between-a-university-teaching-hospital-madrid-region-spain-and-usa-rates
#19
Gil Rodríguez-Caravaca, Pablo Gil-Yonte, Juan Antonio Del-Moral-Luque, Warren Covelé Lucas, José María Fernández-Cebrián, Manuel Durán-Poveda
Background: There are many factors that can influence surgical site infections (SSI) in cholecystectomies. Incidence of cholecystectomy SSI was studied and compared with the incidence in Madrid Region, Spain, and the United States. Methods: A prospective cohort study was conducted which included all patients who underwent gallbladder surgery for 5 consecutive years, at the Alcorcón Foundation University Teaching Hospital. SSI incidence rate was calculated. An association between risk factors and SSI incidence was assessed with the relative risk (RR)...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265112/serological-evidence-of-borrelia-burgdorferi-infection-in-mexican-patients-with-facial-palsy
#20
Guadalupe Gordillo-Pérez, Ireri García-Juárez, Fortino Solórzano-Santos, Lidiette Corrales-Zúñiga, Onofre Muñoz-Hernández, Javier Torres-López
Background: Facial palsy is the most frequent manifestation of neuroborreliosis in the United States, Europe, and Asia, whereas in Mexico, its frequency is unknown. Objective: We aimed to determine the frequency of Borrelia spp. infection in patients with acute facial palsy in Mexico. Materials and Methods: In this cross-sectional, referral hospital-based survey, 191 patients with facial palsy were selected and clinical and epidemiologic data recorded...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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