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Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición

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https://www.readbyqxmd.com/read/27623040/ikaros-gene-deleted-b-cell-acute-lymphoblastic-leukemia-in-mexican-mestizos-observations-in-seven-patients-and-a-short-review-of-the-literature
#1
Guillermo José Ruiz-Delgado, Yahveth Cantero-Fortiz, Andrés Aurelio León-Peña, Mónica León-González, Ana Karen Nuñez-Cortés, Guillermo José Ruiz-Argüelles
BACKGROUND: In B-cell acute lymphoblastic leukemia, one of the most frequent cytogenetic alterations is the presence of the Philadelphia chromosome. Recently, newly identified genetic alterations have been studied, among them the IKZF1 deletion. IKZF1 encodes IKAROS, a zinc finger protein that plays an important role in hematopoiesis involving the regulation process of adhesion, cellular migration, and as a tumor suppressor. OBJECTIVE: We aimed to study the impact of IKAROS deletion in the evolution and prognosis of B-cell acute lymphoblastic leukemia...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27623039/chronic-hepatitis-c-treatment-with-direct-acting-antiviral-agents-in-a-real-life-setting
#2
Ruby Ann Chirino-Sprung, Margarita Dehesa, Enrique Wolpert, Clara Corona-Lau, Ignacio García-Juarez, José Francisco Sánchez-Ávila, Carlos Moctezuma-Velázquez, David Kershenobich
BACKGROUND: In clinical trials, new oral direct-acting antiviral agent therapies have demonstrated a high sustained virological response rate in patients with hepatitis C virus infection. We aimed to analyze the efficacy and safety data from direct-acting antiviral agent interferon-free therapy in hepatitis C virus infection in a study performed in five different clinical settings in Mexico City; four private practice sites and one academic medical center in a real-world scenario. METHODS: Eighty-one patients were treated with seven different direct-acting antiviral agent regimens, in which the end of treatment, sustained virological response at 12 weeks post-treatment, and adverse effects were evaluated...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27623038/clinical-dialytic-and-laboratory-factors-associated-with-poor-health-related-quality-of-life-in-mexican-patients-on-hemodialysis
#3
Edgar Dehesa-López, Ricardo Correa-Rotter, David Olvera-Castillo, Carlos González-Parra, Rafael Baizabal-Olarte
BACKGROUND: End-stage renal disease and its treatment have a negative impact on the quality of life of patients. OBJECTIVE: To determine the clinical, dialytic, and laboratory factors associated with poor health-related quality of life in Mexican patients on hemodialysis. METHODS: A multicenter, cross-sectional study. The KDQOL-SF36 v1.3 questionnaire was applied to patients with end-stage renal disease on hemodialysis in different regions of Mexico...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27623037/estimation-of-the-cost-effectiveness-of-breast-cancer-screening-using-mammography-in-mexico-through-a-simulation
#4
Ernesto Ulloa-Pérez, Alejandro Mohar-Betancourt, Nancy Reynoso-Noverón
BACKGROUND: Currently, breast cancer is the most prevalent tumor among Mexican women. Screening methods such as mammography could potentially reduce the health and economic burden of breast cancer; however, its risk-benefit balance is still unclear. OBJECTIVE: To estimate the cost-effectiveness of different breast cancer screening programs using mammography in Mexico and to contribute to the decision-making process on this preventive measure. METHODS: A simulation study was performed using population data and incidence rates...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27623036/mexican-biosimilar-filgrastim-for-autologous-hematopoietic-stem-cell-mobilization-and-transplantation
#5
Mónica León-González, Andrés A León-Peña, María Fernanda Vallejo-VIllalobos, Ana Karen Núñez-Cortés, Alejandro Ruiz-Argüelles, Guillermo J Ruiz-Argüelles
BACKGROUND: Following the release of the initial presentation of filgrastim (granulocyte colony-stimulating factor), several biosimilars have been developed worldwide. OBJECTIVE: To study the efficacy of a Mexican biosimilar granulocyte colony-stimulating factor in a single transplant center. METHODS: In a group of 19 consecutive patients with multiple sclerosis given autografts, we employed granulocyte colony-stimulating factors to mobilize stem cells from the bone marrow to the peripheral blood, either the original granulocyte colony-stimulating factor (n = 10) or a Mexican granulocyte colony-stimulating factor biosimilar (n = 9)...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27623035/impact-of-a-movement-disorders-clinic-on-the-trends-of-parkinson-s-disease-consultations-at-a-tertiary-referral-center
#6
Teresa Corona, Amin Cervantes-Arriaga, Leora Velásquez-Pérez, Mayela Rodríguez-Violante
BACKGROUND: Outpatient clinics for movement disorders provide specialized diagnosis and treatment services for the specific needs of this patient population. OBJECTIVE: Describe the impact of implementing a Movement Disorder Clinic on the trends of consultations per year and hospitalizations of subjects with Parkinson's disease at a tertiary referral center. METHODS: A retrospective study was carried out. We collected data from the Clinical File Archive and the Epidemiology Department at the National Institute of Neurology and Neurosurgery in Mexico...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27623034/expression-of-her2-neu-in-b-cell-acute-lymphoblastic-leukemia
#7
Sergio Rodriguez-Rodriguez, Alan Pomerantz, Roberta Demichelis-Gomez, Georgina Barrera-Lumbreras, Olga Barrales-Benitez, Alvaro Aguayo-Gonzalez
BACKGROUND: The expression of HER2/neu in B-cell acute lymphoblastic leukemia has been reported in previous studies. OBJECTIVE: The objective of this research was to study the expression of HER2/neu on the blasts of patients with acute leukemia from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. METHODS: From June 2015 to February 2016, a HER2/neu monoclonal antibody was added to the panel of antibodies that we routinely use in patients with acute leukemia...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27623033/classifying-acute-respiratory-distress-syndrome-severity-correcting-the-arterial-oxygen-partial-pressure-to-fractional-inspired-oxygen-at-altitude
#8
Rogelio Pérez-Padilla, Carmen Margarita Hernández-Cárdenas, Gustavo Lugo-Goytia
In the well-known Berlin definition of acute respiratory distress syndrome (ARDS), there is a recommended adjustment for arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FIO2) at altitude, but without a reference as to how it was derived.
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27409003/g80a-single-nucleotide-polymorphism-in-reduced-folate-carrier-1-gene-in-a-mexican-population-and-its-impact-on-survival-in-patients-with-acute-lymphoblastic-leukemia
#9
Myrna Candelaria, Juan Ojeda, Olga Gutiérrez-Hernández, Lucia Taja-Chayeb, Silvia Vidal-Millán, Alfonso Dueñas-González
BACKGROUND: Hyper-CVAD is the treatment for patients with acute lymphoblastic leukemia in our institution. OBJECTIVE: To evaluate the impact of single nucleotide polymorphisms at genes associated with methotrexate metabolism on survival. METHODS: The presence of the single nucleotide polymorphisms G80A at reduced folate carrier-1 gene and C677T in the methylenetetrahydrofolate reductase gene was determined by denaturing high performance liquid chromatography and validated by sequencing...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27409002/clinical-characteristics-and-mortality-of-influenza-a-h1n1-and-influenza-like-illness-in-mexico-city-in-the-2013-2014-winter-season
#10
David Martínez-Briseño, Luis Torre-Bouscoulet, Julio de Jesús Herrera-Zamora, Julián Díaz-Rico, Gabriel Sandoval-Macías, Rogelio Pérez-Padilla, Carmen Hernández-Cárdenas, Justin Regalado-Pineda, Jorge Salas-Hernández, Patricio Santillán-Doherty
BACKGROUND: The 2013-2014 influenza season in Mexico City was severe and mainly due to influenza A H1N1, as was the 2009 pandemic. OBJECTIVE: To describe features of the outbreak and to compare the characteristics of patients with and without viral identification. METHODS: We reviewed the medical charts of all individuals with influenza or influenza-like illness admitted to a referral hospital for respiratory diseases in Mexico City from January 2013 to March 2014, whether influenza virus was identified or not...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27409001/lethal-keratitis-ichthyosis-and-deafness-syndrome-due-to-the-a88v-connexin-26-mutation
#11
Carmen Esmer, Julio C Salas-Alanis, Oscar R Fajardo-Ramirez, Brenda Ramírez, Rong Hua, Keith Choate
Keratitis-ichthyosis-deafness syndrome is a well-characterized disease that has been related to mutations in the GJB6 gene. Clinical features such as erythrokeratoderma, palmoplantar keratoderma, alopecia, and progressive vascularizing keratitis, among others, are well known in this entity. In this report we describe a newborn female patient diagnosed with keratitis-ichthyosis-deafness syndrome with a lethal outcome due to sepsis. The patient harbored the mutation A88V that has been previously reported in lethal cases...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27409000/globe-salvage-with-intra-arterial-topotecan-melphalan-chemotherapy-in-children-with-a-single-eye
#12
Carlos A Leal-Leal, Laura Asencio-López, Jesús Higuera-Calleja, Max Bernal-Moreno, Vanessa Bosch-Canto, Juan Chávez-Pacheco, Gabriela Isaac-Otero, Maja Beck-Popovic
INTRODUCTION: Intra-arterial chemotherapy is a novel therapeutic modality for retinoblastoma patients. Intra-arterial chemotherapy involves the administration of a super-selective drug through the ophthalmic artery, resulting in better ocular penetration and low systemic toxicity. OBJECTIVE: The aim of this report was to evaluate the feasibility of intra-arterial chemotherapy in a large referral center in Mexico City. METHODS: We included patients with bilateral retinoblastoma, one enucleation, and active disease in the other eye after at least two courses of systemic chemotherapy combined with topical treatments...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27408999/hla-risk-haplotype-insulin-deficiency-in-pediatric-type-1-diabetes
#13
Rita A Gómez-Díaz, Elisa Nishimura-Meguro, Eulalia Garrido-Magaña, Lorena Lizárraga-Paulin, Blanca E Aguilar-Herrera, Carolina Bekker-Méndez, Roberto Medina-Santillán, Rodrigo Barquera, Rafael Mondragón-González, Niels H Wacher
BACKGROUND: Certain HLA class II haplotypes have long been related with the risk of developing type 1 diabetes. The presence of the HLA haplotype DRB1*04/DQA1*03/DQB1*03:02, together with specific β-cell autoantibodies, contributes to the development and/or severity of insulin deficiency in type 1 diabetes. OBJECTIVE: To evaluate the association of HLA risk haplotype HLA-DRB1/-DQA1/-DQB1 with β-cell function and antibody markers in recent-onset type 1 diabetes patients, their siblings, and controls...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27408998/effect-of-passive-smoking-on-the-growth-of-pulmonary-function-and-respiratory-symptoms-in-schoolchildren
#14
Rosario Fernández-Plata, Rosalba Rojas-Martínez, David Martínez-Briseño, Cecilia García-Sancho, Rogelio Pérez-Padilla
BACKGROUND: Environmental tobacco smoke affects the current and future health of children. OBJECTIVE: To determine whether schoolchildren aged 8-17 years old residing at an altitude of 2,240 m and exposed to tobacco smoke at home presented a reduction in the growth of pulmonary function and a greater problem of respiratory symptoms and infections compared with non-exposed children. MATERIALS AND METHODS: We followed, with questionnaires and spirometry, 1,632 boys and 1,555 girls from Mexico City and its metropolitan area (the Metropolitan Study to Evaluate the Chronic Effects of Pollution in School-age Children [EMPECE]) every six months for six years...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27408997/clinical-benefit-of-3-tesla-magnetic-resonance-imaging-rescanning-in-patients-with-focal-epilepsy-and-negative-1-5-tesla-magnetic-resonance-imaging
#15
Lady D Ladino, Pedro Balaguera, Simon Rascovsky, Jorge Delgado, Juan Llano, Lizbeth Hernández-Ronquillo, Bety Gómez-Arias, José F Téllez-Zenteno
BACKGROUND: Magnetic resonance imaging is an essential tool in the pre-surgical evaluation of patients with drug-resistant epilepsy. OBJECTIVE: Our aim was to assess the value of re-imaging patients with focal drug-resistant epilepsy. METHODS: Thirty patients with negative or non-conclusive 1.5 Tesla magnetic resonance imaging were rescanned with 1.5T and 3T. All of them had previous 1.5 scans with no seizure protocol in a non-specialized center...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27408996/effect-of-human-breast-milk-on-the-expression-of-proinflammatory-cytokines-in-caco-2-cells-after-hypoxia-re-oxygenation
#16
Wei-Yong Ruan, Ming-Yuan Bi, Wei-Wei Feng, Yu-Jun Wang, Wei-Quan Bu, Ling Lu
BACKGROUND: Neonatal necrotizing enterocolitis is a common and often fatal gastrointestinal disease, especially in premature infants. To study potential mechanisms underlying the protective effect of breast milk on neonatal necrotizing enterocolitis, we induced intestinal inflammation in a Caco-2 cell model of neonatal necrotizing enterocolitis by hypoxia/re-oxygenation to investigate whether breast milk supernatant fluid inhibited the expression of proinflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α...
May 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27103045/predictive-value-of-frailty-indices-for-adverse-outcomes-in-older-adults
#17
Mario Ulises Pérez-Zepeda, Matteo Cesari, Carmen García-Peña
BACKGROUND: There are two widely used tools to classify frailty in older adults: the frailty phenotype and the frailty index. Both have been validated for prediction of adverse outcomes. OBJECTIVE: To assess the ability of different frailty indices to predict a number of adverse outcomes (falls, disability, and mortality) by adding deficits in a fixed sequence (with the first five deficits as in the frailty phenotype: weakness, weight loss, slowness, exhaustion and low physical activity) or randomly...
March 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27103044/the-role-of-immunosenescence-in-the-development-of-age-related-diseases
#18
Tamas Fülöp, Gilles Dupuis, Jacek M Witkowski, Anis Larbi
Aging is a complex phenomenon leading to numerous changes in the physiological systems of the body. One of the most important changes, called immunosenescence, occurs in the immune system. Immunosenescence covers changes in the innate and the adaptive immune systems and is associated with a low-grade inflammation called inflammaging. Aging, likely via inflammaging, is also associated with the emergence of chronic diseases including cardiovascular and neurodegenerative diseases, cancer, and diabetes mellitus type 2...
March 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27103043/aging-and-pulmonary-fibrosis
#19
Moisés Selman, Ivette Buendía-Roldán, Annie Pardo
Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal epigenetic reprogramming that leads to a complex pathogenesis. Idiopathic pulmonary fibrosis occurs in middle-aged and mainly elderly adults, and in this context age has emerged as its strongest risk factor. However, the mechanisms linking it to aging are uncertain...
March 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27103042/aging-kidney-transplantation
#20
Carlos G Musso, María C Giordani, Nora Imperiali
There are several immunological and non-immunological factors related to renal graft deterioration, and histological lesions such as interstitial fibrosis and tubular atrophy overlap with those observed in aging kidneys. Consequently, it has been proposed that kidney transplant senescence could contribute to graft loss. The process of cell senescence displays characteristics such as an increased expression of specific aging suppressor genes, shortened telomeres, mitochondrial changes, increased expression of negative regulators of the cell cycle, and immunological senescence...
March 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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