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Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición

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https://www.readbyqxmd.com/read/29265118/two-hundred-years-later-is-parkinson-s-disease-a-single-defined-entity
#1
Mayela Rodríguez-Violante, Amin Cervantes-Arriaga, Stanley Fahn, Eduardo Tolosa
An Essay on the Shaking Palsy, by James Parkinson, was published in 1817. Later, Jean-Martin Charcot better described some of the motor features of the disease and named the condition as "La Maladie de Parkinson." As understanding about the disease progressed, aided by both clinical expertise and technological developments, the definition of what is Parkinson's disease has evolved. Motor phenotype, non-motor symptoms, monogenic mutations, genetic risk factors, disease subtyping, and data-driven clusters, among other concepts, have given rise to the hypothesis that Parkinson's disease may be not one well-defined entity but several different diseases encompassed as a levodopa-responsive Parkinsonism...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265117/dose-volume-effect-of-acute-diarrhea-in-post-operative-radiation-for-gynecologic-cancer
#2
Qian Li, Jing Chen, Biqing Zhu, Minghua Jiang, Wei Liu, Emei Lu, Qiao-Ling Liu
Background: Diarrhea is the primary symptom of concern in acute post-operative radiation-induced enteritis in gynecologic cancer. We retrospectively studied the correlation between the volume of irradiated small bowel and the development of acute diarrhea in these patients. Materials and Methods: A total of 100 post-operative gynecologic cancer patients were analyzed. Pelvic computed tomography was performed to calculate the volume of irradiated small bowel. A dose-volume histogram was calculated from 5 to 40 Gy at 5 Gy intervals...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265116/abnormal-cardiovascular-findings-in-acute-pancreatitis-are-they-associated-with-disease-severity
#3
Martin A Chacón-Portillo, Gerardo Payró-Ramírez, Mario C Peláez-Luna, Luis F Uscanga-Domínguez, Zuilma Vasquéz-Ortiz, Consuelo Orihuela, Sophia E Martínez-Vázquez, Jorge Hernández-Calleros
Background: Acute pancreatitis (AP), a disease that commonly requires in-hospital treatment, has been associated with a high incidence of abnormal cardiovascular findings (ACFs). We conducted a prospective study to explore the association of these findings with severity of the disease. Methods: Adult patients with AP diagnosis were prospectively enrolled in an observational study during an 8-month period in a tertiary care center. AP and its severity were defined according to the Revised Atlanta Classification of AP...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265115/chikungunya-molecular-aspects-clinical-outcomes-and-pathogenesis
#4
Eduardo Bautista-Reyes, Daniel Núñez-Avellaneda, Luis Antonio Alonso-Palomares, Ma Isabel Salazar
The alarming worldwide emergence of the chikungunya virus began in the last decade. Since the first autochthonous transmission in Mexico in November of 2014, the virus has spread throughout the country, resulted in multiple outbreaks. This virus produces an acute and self-limiting disease characterized by fever, polyarthralgia, myalgia, exanthema, and general malaise. It is transmitted to humans by the bite of Aedes aegypti and A. albopictus mosquitoes. The fact that the clinical presentation is similar to that produced by other arboviruses complicates its clinical diagnosis...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265114/distinguishing-intracerebral-hemorrhage-from-acute-cerebral-infarction-through-metabolomics
#5
Xuxin Zhang, Yanzhao Li, Yan Liang, Pitong Sun, Xue Wu, Jinhui Song, Xiaoyu Sun, Mo Hong, Peng Gao, Dongfeng Deng
Background: Acute cerebral infarction (ACI) and intracerebral hemorrhage (ICH) are potentially lethal cerebrovascular diseases that seriously impact public health. ACI and ICH share several common clinical manifestations but have totally divergent therapeutic strategies. A poor diagnosis can affect stroke treatment. Objective: To screen for biomarkers to differentiate ICH from ACI, we enrolled 129 ACI and 128 ICH patients and 65 healthy individuals as controls. Methods: Patients with stroke were diagnosed by computed tomography/magnetic resonance imaging, and their blood samples were obtained by fingertip puncture within 2-12 h after stroke initiation...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265113/rates-of-surgical-site-infection-in-cholecystectomy-comparison-between-a-university-teaching-hospital-madrid-region-spain-and-usa-rates
#6
Gil Rodríguez-Caravaca, Pablo Gil-Yonte, Juan Antonio Del-Moral-Luque, Warren Covelé Lucas, José María Fernández-Cebrián, Manuel Durán-Poveda
Background: There are many factors that can influence surgical site infections (SSI) in cholecystectomies. Incidence of cholecystectomy SSI was studied and compared with the incidence in Madrid Region, Spain, and the United States. Methods: A prospective cohort study was conducted which included all patients who underwent gallbladder surgery for 5 consecutive years, at the Alcorcón Foundation University Teaching Hospital. SSI incidence rate was calculated. An association between risk factors and SSI incidence was assessed with the relative risk (RR)...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29265112/serological-evidence-of-borrelia-burgdorferi-infection-in-mexican-patients-with-facial-palsy
#7
Guadalupe Gordillo-Pérez, Ireri García-Juárez, Fortino Solórzano-Santos, Lidiette Corrales-Zúñiga, Onofre Muñoz-Hernández, Javier Torres-López
Background: Facial palsy is the most frequent manifestation of neuroborreliosis in the United States, Europe, and Asia, whereas in Mexico, its frequency is unknown. Objective: We aimed to determine the frequency of Borrelia spp. infection in patients with acute facial palsy in Mexico. Materials and Methods: In this cross-sectional, referral hospital-based survey, 191 patients with facial palsy were selected and clinical and epidemiologic data recorded...
November 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077701/histology-as-prognostic-factor-in-early-stage-cervical-carcinoma-experience-in-a-third-level-institution
#8
Salim Abraham Barquet-Muñoz, Efraín Cruz-Rodríguez, David Francisco Cantú De León, David Isla-Ortiz, Gonzalo Montalvo-Esquivel, Luis Alonso Herrera-Montalvo, Carlos Pérez-Plasencia, Delia Pérez-Montiel, Ángel Herrera-Gómez
BACKGROUND: Cervical carcinoma (CC) is one of the most frequent neoplasms, especially in developing countries. The most common histopathological type is squamous cell carcinoma (SCC), followed by adenocarcinoma (AC) and adenosquamous carcinoma (ASC). Prognosis according to histological type is controversial. OBJECTIVE: The objective of this study is to describe and compare the prognoses of the most common histologies of CC in the early stages. MATERIALS AND METHODS: We reviewed records of patients attended at the Instituto Nacional de Cancerología of Mexico with CC surgically treated Stages IA2-IB1 and IIA1, including the histological types SCC, AC, and ASC...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077700/electroencephalographic-indicators-in-default-mode-habituation-and-visual-motor-association-in-female-college-students
#9
Héctor Brust-Carmona, Yessica Martínez-Serrato, Ana Sánchez-Quezada, Blanca Flores-Avalos, Javier Alducin-Castillo, Oscar Yáñez-Suarez
BACKGROUND: Oscillations, action, and postsynaptic potentials in glial-neuronal ensembles integrate the spectral power (SP) of electroencephalographic (EEG). Our objective is to propose SP indicators of healthy brains (control groups) based on the default mode and their modifications by habituation and visual-motor association (VM-asso), to support diagnostic and rehabilitation processes. However, important differences seem to exist between men and women. Therefore, we aim to analyze EEG characteristics in a female sample...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077699/pneumococcal-conjugate-vaccine-and-pneumonia-prevention-in-children-with-congenital-heart-disease
#10
Fortino Solórzano-Santos, Lilia Espinoza-García, Glorinella Aguilar-Martínez, Luisa Beirana-Palencia, Gabriela Echániz-Avilés, Guadalupe Miranda-Novales
BACKGROUND: A successful strategy to prevent Streptococcus pneumoniae infections is the administration of pneumococcal conjugate vaccines (PCVs). OBJECTIVE: To analyze the effectiveness of the 7- and 13-valent PCV for the prevention of all-cause pneumonia. MATERIALS AND METHODS: A retrospective cohort of children younger than 5 years of age, with congenital heart disease (CHD) and different vaccination schedules, was analyzed. History of vaccination was confirmed with verifiable records...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077698/prevalence-of-human-papillomavirus-in-women-from-the-state-of-michoacan-mexico-showed-high-frequency-of-unusual-virus-genotypes
#11
Irvin Jácome-Galarza, María Ayumi Ito-Nakashimada, Gloria Figueroa-Aguilar, Ethel García-Latorre, M A Isabel Salazar, Eduardo López-Orduña, Alejandro D Camacho, Juan José Valdez-Alarcón, José Manuel Hernández, Gloria León-Avila
BACKGROUND: Human papillomaviruses (HPVs), the leading cause of cervical cancer, are distributed worldwide, with high prevalence in developing countries. OBJECTIVE: The objective of the study is to know the prevalence and genotypes of HPV in women from the state of Michoacán and the Women's Hospital in Morelia, Michoacán. MATERIALS AND METHODS: Cervical smear samples (159,288) were subjected to HPV detection by hybrid capture 2. A subsample of 484 patients from the Women's Hospital was studied by Papanicolaou test and linear array HPV genotyping, and when positive, patients were also examined by colposcopy and histopathology...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077697/assessment-of-liver-fibrosis-using-real-time-shear-wave-elastography-for-patients-with-hepatitis-b-e-antigen-negative-chronic-hepatitis-b-and-alanine-transaminase-2-times-the-upper-limit-of-normal
#12
Jing-Hua Liu, Yu Zou, Wei Chang, Jun Wu, Yu Zou, Yu-Chen Xie, Yong-Ping Lu, Jia Wei
BACKGROUND: We assessed liver fibrosis using real-time shear-wave elastography (SWE) combined with liver biopsy (LB) for patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) and alanine transaminase < 2 times the upper limit of normal and hepatitis B virus DNA < 2000 IU/ml. METHODS: A total of 107 patients met the inclusion criteria. Real- ime SWE and ultrasoundassisted liver biopsies were consecutively performed. Fibrosis was staged according to the METAVIR scoring system...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077696/hyperuricemia-on-admission-predicts-short-term-mortality-due-to-myocardial-infarction-in-a-population-with-high-prevalence-of-cardiovascular-risk-factors
#13
Mauricio Mora-Ramírez, Irving O Estevez-Garcia, María E Irigoyen-Camacho, Rafael Bojalil, Héctor Gonzalez-Pacheco, Luis M Amezcua-Guerra
BACKGROUND: National health surveys have revealed an outstandingly high prevalence of obesity, hypertension, and diabetes in Mexico. OBJECTIVE: To assess whether serum uric acid levels on admission may predict short-term mortality in patients with ST-segment elevation myocardial infarction in a population with an unusually high prevalence of classic cardiovascular risks. METHODS: A total of 795 ST-segment elevation myocardial infarction patients undergoing primary reperfusion therapy were classified as having normouricemia or hyperuricemia according to serum uric acid levels at admission, and the occurrence of mortality and major adverse cardiovascular events during coronary care unit stay was assessed...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077695/human-b-regulatory-cells-the-new-players-in-autoimmune-disease
#14
José L Maravillas-Montero, Ernesto Acevedo-Ochoa
Although the production of antigen-specific antibodies has been the originally accepted function of B-cells during immune responses, specific subsets that can negatively regulate inflammation, designated regulatory B-cells (Bregs), have been identified recently. These immunosuppressive cells support tolerance, mainly through the production of interleukin 10 and other unconventional factors. There have been emerging data suggesting their importance in diverse normal and pathologic processes. Novel and in development B-cell targeted therapies seem to be ideal treatments for different types of diseasessuch as cancer and allergy...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29077694/practical-approach-to-the-evaluation-and-management-of-rheumatoid-arthritis-interstitial-lung-disease-based-on-its-proven-and-hypothetical-mechanisms
#15
Francisco Paulin, Alejandra Babini, Marta Mamani, Juan Mercado, Fabián Caro
The prevalence of interstitial lung disease in patients with rheumatoid arthritis varies from 10 to 42%. Rheumatoid arthritis patients with interstitial lung disease have three times the risk of death compared with those without the disease. Prognosis seems to be related to the high-resolution computed tomography pattern. Usual interstitial pneumonia pattern, resembling idiopathic pulmonary fibrosis, carries a worse prognosis. Validated strategies to identify different phenotypes and assess the disease activity in rheumatoid arthritis interstitial lung disease are lacking...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28776607/-joven-fuerte-program-for-young-women-with-breast-cancer-in-mexico-%C3%A2-initial-results
#16
Cynthia Villarreal-Garza, Andrea Castro-Sánchez, Alejandra Platas, Melina Miaja, Alejandro Mohar-Betancourt, Regina Barragan-Carrillo, Alan Fonseca, Yoatzin Vega, B Alejandra Martinez-Cannon, Dione Aguilar, Enrique Bargalló-Rocha, Servando Cardona-Huerta, Omar Peña-Curiel, Juan Matus-Santoso
Despite the high rates of breast cancer among young Mexican women, their special needs and concerns have not been systematically addressed. To fulfill these unsatisfied demands, we have developed "Joven & Fuerte: Program for Young Women with Breast Cancer in Mexico," the first program dedicated to the care of young breast cancer patients in Latin America, which is taking place at the National Cancer Institute of Mexico and the two medical facilities of the Instituto Tecnológico y de Estudios Superiores de Monterrey...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28776606/special-needs-of-young-women-with-breast-cancer-in-limited-resource-settings
#17
Carmen Lizette Gálvez-Hernández, María Cecilia González-Robledo, Regina Barragán-Carrillo, Cynthia Villarreal-Garza
BACKGROUND: Young women with breast cancer (YWBC) comprise a group of patients with unique biopsychosocial characteristics with a special perception of needs throughout their disease and survivorship. Contexts marked by restricted allocations and economic constraints might further aggravate the struggle of these patients living within limited resource settings and can demand added requirements for them and their families. OBJECTIVE: To analytically explore the existing knowledge regarding the needs of YWBC in low- and middle- income countries (LMICs)...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28776605/psychological-impact-of-alterations-in-sexuality-fertility-and-body-image-in-young-breast-cancer-patients-and-their-partners
#18
Melina Miaja, Alejandra Platas, Bertha Alejandra Martinez-Cannon
Young women with breast cancer have age-specific concerns regarding changes in sexuality, fertility, and body image. However, the psychological impact of BC and its treatments is not exclusive to young patients and it also affects their social context, especially their partners, as they experience higher illness intrusiveness than the partners of older women. In young BC patients, relationships, body image, and sexual problems are related to most quality of life domains. While BC treatment is being planned, all women should be informed about the possible side-effects of treatment on sexuality, fertility, and body image...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28776604/the-role-of-diet-physical-activity-body-fatness-and-breastfeeding-in-breast-cancer-in-young-women-epidemiological-evidence
#19
I Isabelle Romieu, A Amadou, V Chajes
The incidence of breast cancer (BC) is rising worldwide, with an increase in aggressive neoplasias in young women. Traditionally, BC in young women has been thought to be etiologically driven, primarily by genetic/hereditary factors. However, these factors explain only a small proportion of BCs, pointing to a role of the environment. Suspected factors responsible for this increase include lifestyle changes, notably alcohol consumption, diet with high intake of refined carbohydrates and saturated fat and low intake of polyunsaturated fatty acids (PUFA), fiber and vitamins (such as folate, vitamin D, and carotenoids), low physical activity, and body fatness, all of which may act from childhood and adolescent years through adulthood...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28776603/molecular-biology-in-young-women-with-breast-cancer-from-tumor-gene-expression-to-dna-mutations
#20
Liliana Gómez-Flores-Ramos, Andrea Castro-Sánchez, Omar Peña-Curiel, Alejandro Mohar-Betancourt
Young women with breast cancer (YWBC) represent roughly 15% of breast cancer (BC) cases in Latin America and other developing regions. Breast tumors occurring at an early age are more aggressive and have an overall worse prognosis compared to breast tumors in postmenopausal women. The expression of relevant proliferation biomarkers such as endocrine receptors and human epidermal growth factor receptor 2 appears to be unique in YWBC. Moreover, histopathological, molecular, genetic, and genomic studies have shown that YWBC exhibit a higher frequency of aggressive subtypes, differential tumor gene expression, increased genetic susceptibility, and specific genomic signatures, compared to older women with BC...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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