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Clinical Chemistry

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https://www.readbyqxmd.com/read/28302731/selecting-statistical-quality-control-procedures-for-limiting-the-impact-of-increases-in-analytical-random-error-on-patient-safety
#1
Martín Yago
BACKGROUND: QC planning based on risk management concepts can reduce the probability of harming patients due to an undetected out-of-control error condition. It does this by selecting appropriate QC procedures to decrease the number of erroneous results reported. The selection can be easily made by using published nomograms for simple QC rules when the out-of-control condition results in increased systematic error. However, increases in random error also occur frequently and are difficult to detect, which can result in erroneously reported patient results...
March 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28302730/distinguishing-intake-of-new-synthetic-cannabinoids-adb-pinaca-and-5f-adb-pinaca-with-human-hepatocyte-metabolites-and-high-resolution-mass-spectrometry
#2
Jeremy Carlier, Xingxing Diao, Karl B Scheidweiler, Marilyn A Huestis
BACKGROUND: ADB-PINACA and its 5-fluoropentyl analog 5F-ADB-PINACA are among the most potent synthetic cannabinoids tested to date, with several severe intoxication cases. ADB-PINACA and 5F-ADB-PINACA have a different legal status, depending on the country. Synthetic cannabinoid metabolites predominate in urine, making detection of specific metabolites the most reliable way for proving intake in clinical and forensic specimens. However, there are currently no data on ADB-PINACA and 5F-PINACA metabolism...
March 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28298413/the-reproducibility-wars-successful-unsuccessful-uninterpretable-exact-conceptual-triangulated-contested-replication
#3
John P A Ioannidis
No abstract text is available yet for this article.
March 15, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28298412/emerging-considerations-for-noninvasive-prenatal-testing
#4
Nichole Korpi-Steiner, Rossa W K Chiu, Subhashini Chandrasekharan, Lyn S Chitty, Mark I Evans, Judith A Jackson, Glenn E Palomaki
No abstract text is available yet for this article.
March 15, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28298411/demonstration-of-automated-analysis-of-multiple-analytes-on-an-integrated-digital-microfluidic-platform
#5
Richard B Fair
No abstract text is available yet for this article.
March 15, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28283556/utilization-of-reflex-testing-for-direct-bilirubin-in-the-early-recognition-of-biliary-atresia
#6
Leo Lam, Samarina Musaad, Campbell Kyle, Stephen Mouat
BACKGROUND: Delayed diagnosis of biliary atresia is an important cause of pediatric end-stage liver failure and liver transplantation. We sought to determine whether direct bilirubin is underutilized by retrospectively reviewing patients with biliary atresia. Further, we aimed to determine the role of reflex testing for direct bilirubin in patients suspected for jaundice. METHODS: The time intervals between total bilirubin and direct bilirubin measurements were retrospectively reviewed in patients with biliary atresia...
March 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28280053/copeptin-associates-with-cause-specific-mortality-in-patients-with-impaired-renal-function-results-from-the-luric-and-the-4d-study
#7
Vera Krane, Bernd Genser, Marcus E Kleber, Christiane Drechsler, Winfried März, Graciela Delgado, Bruno Allolio, Christoph Wanner, Wiebke Fenske
BACKGROUND: In chronic kidney disease (CKD) arginine vasopressin (AVP) cannot efficiently act via renal V2-receptors. AVP is upregulated leading to augmented activation of V1a- and V1b-receptors, which might contribute to the increase in cardiovascular and infectious complications in CKD. Here, we evaluate copeptin, a surrogate of AVP, and its association with cause specific mortality among patients within the whole spectrum of renal function. METHODS: Copeptin was measured in baseline samples from the LURIC (n = 3131 patients with coronary angiograms) and the 4D-Study (n = 1241 type 2 diabetic hemodialysis patients)...
March 9, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28280052/cross-sectional-analysis-of-age-cml-srage-and-esrage-with-diabetes-and-cardiometabolic-risk-factors-in-a-community-based-cohort
#8
Stephanie J Loomis, Yuan Chen, David B Sacks, Eric S Christenson, Robert H Christenson, Casey M Rebholz, Elizabeth Selvin
BACKGROUND: Advanced glycation end products (AGEs) and their receptors are regarded as central to the development of diabetic complications, but associations with diabetes and cardiometabolic outcomes in previous studies are mixed. METHODS: Using ELISA assays, we measured N(6)-carboxymethyllysine (AGE-CML), soluble receptor for AGEs (sRAGE), and endogenous secreted receptor for AGEs (esRAGE) in 1874 participants from the Atherosclerosis Risk in Communities study...
March 9, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28280051/using-biomarkers-to-guide-heart-failure-therapy
#9
Allan S Jaffe, James L Januzzi
No abstract text is available yet for this article.
March 9, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28280050/single-stranded-dna-library-preparation-preferentially-enriches-short-maternal-dna-in-maternal-plasma
#10
Joaquim S L Vong, Jason C H Tsang, Peiyong Jiang, Wing-Shan Lee, Tak Yeung Leung, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo
BACKGROUND: Recent studies have suggested that single-stranded DNA (ssDNA) library preparation can enrich short DNA species from the plasma of healthy individuals, cancer patients, and transplant recipients. Based on previous observations that fetal DNA molecules in the maternal plasma are shorter than maternal DNA molecules, ssDNA library preparation may potentially enrich fetal DNA and provide substantial improvement in noninvasive prenatal testing. METHODS: We tested this hypothesis by comparing the maternal plasma DNA sequencing results using 2 types of ssDNA library preparation methods and a standard double-stranded DNA (dsDNA) library method using samples from first- and third-trimester pregnancies...
March 9, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28270433/waste-leaks-and-failures-in-the-biomarker-pipeline
#11
REVIEW
John P A Ioannidis, Patrick M M Bossuyt
BACKGROUND: The large, expanding literature on biomarkers is characterized by almost ubiquitous significant results, with claims about the potential importance, but few of these discovered biomarkers are used in routine clinical care. CONTENT: The pipeline of biomarker development includes several specific stages: discovery, validation, clinical translation, evaluation, implementation (and, in the case of nonutility, deimplementation). Each of these stages can be plagued by problems that cause failures of the overall pipeline...
March 7, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28249843/a-novel-discovery-platform-aptamers-for-the-quantification-of-human-proteins
#12
Geoffrey S Baird, Andrew N Hoofnagle
No abstract text is available yet for this article.
March 1, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28213568/estimated-glomerular-filtration-rate-and-albuminuria-are-associated-with-biomarkers-of-cardiac-injury-in-a-population-based-cohort-study-the-maastricht-study
#13
Remy J H Martens, Dorien M Kimenai, Jeroen P Kooman, Coen D A Stehouwer, Frans E S Tan, Otto Bekers, Pieter C Dagnelie, Carla J H van der Kallen, Abraham A Kroon, Karel M L Leunissen, Frank M van der Sande, Nicolaas C Schaper, Simone J S Sep, Miranda T Schram, Jeroen D van Suijlen, Marja P van Dieijen-Visser, Steven J R Meex, Ronald M A Henry
BACKGROUND: Chronic kidney disease (CKD) is associated with an increased cardiovascular disease mortality risk. It is, however, less clear at what point in the course from normal kidney function to CKD the association with cardiovascular disease appears. Studying the associations of estimated glomerular filtration rate (eGFR) and albuminuria with biomarkers of (subclinical) cardiac injury in a population without substantial CKD may clarify this issue. METHODS: We examined the cross-sectional associations of eGFR and urinary albumin excretion (UAE) with high-sensitivity cardiac troponin (hs-cTn) T, hs-cTnI, and N-terminal probrain natriuretic-peptide (NT-proBNP) in 3103 individuals from a population-based diabetes-enriched cohort study...
February 17, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28209628/cystatin-c-incremental-improvement-in-measurement-and-understanding-of-results
#14
EDITORIAL
Gunnar Nordin
No abstract text is available yet for this article.
February 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28209627/characterization-of-a-blood-spot-creatine-kinase-skeletal-muscle-isoform-immunoassay-for-high-throughput-newborn-screening-of-duchenne-muscular-dystrophy
#15
Stuart J Moat, Teemu Korpimäki, Petra Furu, Harri Hakala, Hanna Polari, Liisa Meriö, Pauliina Mäkinen, Ian Weeks
BACKGROUND: Duchenne muscular dystrophy (DMD) is a progressive, lethal X-linked neuromuscular disorder with an average worldwide incidence of 1:5000. Blood spot creatine kinase (CK) enzyme assays previously used in newborn screening programs for DMD are nonspecific because measured CK enzyme activity is attributable to 3 isoenzyme forms of CK (CK-MM, CK-MB, and CK-BB) and it is the CK-MM isoform that is found predominantly in skeletal muscle. CK-MM is increased in boys with DMD owing to muscle damage...
February 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28209626/predicting-asthma-exacerbations-from-a-drop-of-blood
#16
EDITORIAL
Christina Ellervik, Samia Mora
No abstract text is available yet for this article.
February 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28209625/association-of-blood-eosinophil-and-blood-neutrophil-counts-with-asthma-exacerbations-in-the-copenhagen-general-population-study
#17
Signe Vedel-Krogh, Sune Fallgaard Nielsen, Peter Lange, J Rgen Vestbo, B Rge Gr Nne Nordestgaard
BACKGROUND: Blood eosinophil count is a marker of eosinophilic airway inflammation and disease severity in asthma. However, blood neutrophil count might also be associated with disease severity. We tested the hypothesis that high blood eosinophil and neutrophil counts are both associated with the risk of asthma exacerbations among individuals with asthma from the general population. METHODS: From the Copenhagen General Population Study with 81351 participants, we included 4838 with self-reported asthma...
February 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28196921/noninvasive-prenatal-screening-of-fetal-aneuploidy-without-massively-parallel-sequencing
#18
Chenming Xu, Ting Wang, Chao Liu, Hong Li, Xiaoyan Chen, Huanhuan Zhu, Songchang Chen, Qiuhong Xin, Jing Tao, Liming Huang, Zhengwen Jiang
BACKGROUND: Noninvasive prenatal screening (NIPS) using plasma cell-free DNA has gained tremendous popularity in the clinical assessment of fetal aneuploidy. Most, if not all, of these tests rely on complex and expensive massively parallel sequencing (MPS) techniques, hindering the use of NIPS as a common screening procedure. METHODS: We have developed and optimized an MPS-independent noninvasive genetic test that can rapidly detect fetal aneuploidy at considerably lower costs...
February 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28196920/liquid-chromatography-tandem-mass-spectrometry-assay-of-leukocyte-acid-%C3%AE-glucosidase-for-post-newborn-screening-evaluation-of-pompe-disease
#19
Na Lin, Jingyu Huang, Sara Violante, Joseph J Orsini, Michele Caggana, Erin E Hughes, Colleen Stevens, Lisa DiAntonio, Hsuan Chieh Liao, Xinying Hong, Farideh Ghomashchi, Arun Babu Kumar, Hui Zhou, Ruth Kornreich, Melissa Wasserstein, Michael H Gelb, Chunli Yu
BACKGROUND: Pompe disease (PD) is the first lysosomal storage disorder to be added to the Recommended Uniform Screening Panel for newborn screening. This condition has a broad phenotypic spectrum, ranging from an infantile form (IOPD), with severe morbidity and mortality in infancy, to a late-onset form (LOPD) with variable onset and progressive weakness and respiratory failure. Because the prognosis and treatment options are different for IOPD and LOPD, it is important to accurately determine an individual's phenotype...
February 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28196919/estimates-of-within-subject-biological-variation-of-protein-c-antithrombin-protein-s-free-protein-s-activity-and-activated-protein-c-resistance-in-pregnant-women
#20
Ann H Kristoffersen, Per H Petersen, Thomas R Raas, Sverre Sandberg
BACKGROUND: In pregnancy, interpretation of results from coagulation parameters can be difficult because of the procoagulant physiological changes. The aim of this study was to describe the course of 5 coagulation parameters (thrombophilia markers) in healthy pregnancies, and to estimate and compare the within-subject biological variation (CVI) of these parameters in healthy pregnant and nonpregnant women. METHODS: Blood samples were obtained every 4th week during pregnancy and 3 samples after delivery in 20 healthy women and every 4th week during 40 weeks in 19 healthy nonpregnant women...
February 14, 2017: Clinical Chemistry
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