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Clinical Chemistry

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https://www.readbyqxmd.com/read/28646034/prognostic-value-of-serum-troponin-t-in-unstable-angina
#1
Hugo A Katus, Evangelos Giannitsis
No abstract text is available yet for this article.
June 23, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28646033/implementing-a-reference-measurement-system-for-c-peptide-successes-and-lessons-learned
#2
Randie R Little, Robert I Wielgosz, Ralf Josephs, Tomoya Kinumi, Akiko Takatsu, Hongmei Li, Daniel Stein, Chris Burns
BACKGROUND: Assessment of endogenous insulin secretion by measuring C-peptide concentrations is widely accepted. Recent studies have shown that preservation of even small amounts of endogenous C-peptide production in patients with type 1 diabetes reduces risks for diabetic complications. Harmonization of C-peptide results will facilitate comparison of data from different research studies and later among clinical laboratory results at different sites using different assay methods. CONTENT: This review provides an overview of the general process of harmonization and standardization and the challenges encountered with implementing a reference measurement system for C-peptide...
June 23, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28637770/analgesia-and-opioids-a-pharmacogenetics-shortlist-for-implementation-in-clinical-practice
#3
REVIEW
Maja Matic, Saskia N de Wildt, Dick Tibboel, Ron H N van Schaik
BACKGROUND: The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) could possibly be used to tailor pain medication based on an individual's genetic background. Many potential genetic markers have been described, and the importance of genetic predisposition in opioid efficacy and toxicity has been demonstrated in knockout mouse models and human twin studies. Such predictors are especially of value for neonates and young children, in whom the assessment of efficacy or side effects is complicated by the inability of the patient to communicate this properly...
June 21, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28634223/refining-measurement-of-hemoglobin-a1c
#4
David B Sacks, Ionut Bebu, John M Lachin
No abstract text is available yet for this article.
June 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28634222/the-role-of-procalcitonin-in-diagnosis-of-sepsis-and-antibiotic-stewardship-opportunities-and-challenges
#5
Angela W S Fung, Daniel Beriault, Eleftherios P Diamandis, Carey-Ann D Burnham, Todd Dorman, Mark Downing, Joshua Hayden, Bradley J Langford
No abstract text is available yet for this article.
June 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28630238/impact-of-sex-on-cardiac-troponin-concentrations-a-critical-appraisal
#6
REVIEW
Kai M Eggers, Bertil Lindahl
BACKGROUND: The use of sex-specific cutoffs for cardiac troponin (cTn) is currently debated. Although endorsed by scientific working groups, concerns have been raised that sex-specific cutoffs may have only a small clinical effect at the cost of increased complexity in decision-making. METHODS: We reviewed studies investigating the interrelations between high-sensitivity (hs) cTn results and sex, diagnoses, and outcome. Investigated populations included community-dwelling subjects and patients with stable angina, congestive heart failure, or acute chest pain including those with acute coronary syndromes...
June 19, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28630237/facilitating-prospective-registration-of-diagnostic-accuracy-studies-a-stard-initiative
#7
Daniël A Korevaar, Lotty Hooft, Lisa M Askie, Virginia Barbour, Hélène Faure, Constantine A Gatsonis, Kylie E Hunter, Herbert Y Kressel, Hannah Lippman, Matthew D McInnes, David Moher, Nader Rifai, Jérémie F Cohen, Patrick M Bossuyt
No abstract text is available yet for this article.
June 19, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28615231/single-nucleotide-polymorphism-leading-to-false-allelic-fraction-by-droplet-digital-pcr
#8
Eric S Christenson, William B Dalton, David Chu, Ian Waters, Karen Cravero, Daniel J Zabransky, Amy DeZern, Ben Ho Park
BACKGROUND: Molecular-based diagnostics have great utility for cancer detection. We have used droplet digital PCR (ddPCR) as a platform for identifying mutations in circulating plasma tumor DNA (ptDNA). We present the unexpected finding of a spurious mutant allele fraction that was discovered to be artifactual because of the presence of a single-nucleotide polymorphism (SNP) in a patient sample. DESIGN AND METHODS: Probe and primer combinations for the K700 and V701 loci of the SF3B1 spliceosome gene were designed for ddPCR to identify the percentage of mutant and wild-type alleles...
June 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28615230/rapid-rhd-zygosity-determination-using-digital-pcr
#9
Kelly A Sillence, Amr J Halawani, Wajnat A Tounsi, Kirsty A Clarke, Michele Kiernan, Tracey E Madgett, Neil D Avent
BACKGROUND: Paternal zygosity testing is used for determining homo- or hemizygosity of RHD in pregnancies that are at a risk of hemolytic disease of the fetus and newborn. At present, this is achieved by using real-time PCR or the Rhesus box PCR, which can be difficult to interpret and unreliable, particularly for black African populations. METHODS: DNA samples extracted from 58 blood donors were analyzed using 2 multiplex reactions for RHD-specific targets against a reference (AGO1)(2) to determine gene dosage by digital PCR...
June 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28615229/cardiac-troponins-and-their-prognostic-importance-in-patients-with-suspected-acute-coronary-syndrome-and-renal-dysfunction
#10
Kai M Eggers, Bertil Lindahl, Juan J Carrero, Marie Evans, Karolina Szummer, Tomas Jernberg
BACKGROUND: Cardiac troponin (cTn) is important for risk assessment in patients with suspected acute coronary syndrome (ACS). cTn concentrations may, however, be affected by renal dysfunction, and the clinical importance of this interrelation is not well established. We investigated the association between cTnT and cTnI (measured with conventional assays and a more sensitive assay) with the estimated glomerular filtration rate (eGFR) and also assessed the ability of cTn to predict the 1-year all-cause mortality...
June 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28615228/stronger-together-aggregated-z-values-of-traditional-quality-control-measurements-and-patient-medians-improve-detection-of-biases
#11
Andreas Bietenbeck, Markus A Thaler, Peter B Luppa, Frank Klawonn
BACKGROUND: In clinical chemistry, quality control (QC) often relies on measurements of control samples, and limitations, such as a lack of commutability, compromise the ability of such measurements to detect out-of-control situations. Medians of patient results have also been used for QC purposes, but it may be difficult to distinguish changes observed in the patient population from analytical errors. This study aims to combine traditional control measurements and patient medians for facilitating detection of biases...
June 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28606915/baseline-circulating-fgf21-concentrations-and-increase-after-fenofibrate-treatment-predict-more-rapid-glycemic-progression-in-type-2-diabetes-results-from-the-field-study
#12
Kwok-Leung Ong, Rachel O'Connell, Andrzej S Januszewski, Alicia J Jenkins, Aimin Xu, David R Sullivan, Philip J Barter, Russell S Scott, Marja-Riitta Taskinen, Boris Waldman, Peter G Colman, James D Best, John R Simes, Kerry-Anne Rye, Anthony C Keech
BACKGROUND: It is not known whether circulating fibroblast growth factor 21 (FGF21) concentrations are associated with glycemic progression in patients with established type 2 diabetes. This study reports this relationship in type 2 diabetes patients participating in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. METHODS: Plasma FGF21 was quantified in 9697 study participants. Among patients with lifestyle-only glucose control measures at baseline, glycemic progression was defined as the initiation of oral hypoglycemic agents or insulin therapy...
June 12, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28606914/raising-the-bar-further-improvement-is-required-to-make-more-test-accuracy-research-fit-for-decision-making
#13
Jonathan J Deeks
No abstract text is available yet for this article.
June 12, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28606913/miqe-a-step-toward-more-robust-and-reproducible-quantitative-pcr
#14
Stephen A Bustin, Carl T Wittwer
No abstract text is available yet for this article.
June 12, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28606912/a-new-start-for-triglycerides-and-remnant-cholesterol-nonfasting
#15
Børge G Nordestgaard
No abstract text is available yet for this article.
June 12, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28606911/overinterpretation-of-research-findings-evidence-of-spin-in-systematic-reviews-of-diagnostic-accuracy-studies
#16
Trevor A McGrath, Matthew D F McInnes, Nick van Es, Mariska M G Leeflang, Daniël A Korevaar, Patrick M M Bossuyt
BACKGROUND: We wished to assess the frequency of overinterpretation in systematic reviews of diagnostic accuracy studies. METHODS: MEDLINE was searched through PubMed from December 2015 to January 2016. Systematic reviews of diagnostic accuracy studies in English were included if they reported one or more metaanalyses of accuracy estimates. We built and piloted a list of 10 items that represent actual overinterpretation in the abstract and/or full-text conclusion, and a list of 9 items that represent potential overinterpretation...
June 12, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28592445/lymphocyte-galactocerebrosidase-activity-by-lc-ms-ms-for-post-newborn-screening-evaluation-of-krabbe-disease
#17
Hsuan-Chieh Liao, Zdenek Spacil, Farideh Ghomashchi, Maria L Escolar, Joanne Kurtzberg, Joseph J Orsini, Frantisek Turecek, C Ronald Scott, Michael H Gelb
BACKGROUND: Deficiency of the lysosomal enzyme galactosylcerebrosidase (GALC) causes Krabbe disease. Newborn screening for Krabbe disease is ongoing, but improved methods for follow-up analysis of screen-positive babies are needed to better advise families and to optimize treatment. We report a new assay for the enzymatic activity of GALC in lymphocytes. METHODS: T lymphocytes were isolated from venous blood by magnetic bead technology. The assay used a close structural analog of the natural substrate and LC-MS/MS to quantify the amount of product with the aid of a chemically identical internal standard...
June 7, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28588123/a-genoproteomic-approach-to-detect-peptide-markers-of-bacterial-respiratory-pathogens
#18
Honghui Wang, Steven K Drake, Chen Yong, Marjan Gucek, Matthew A Lyes, Avi Z Rosenberg, Erik Soderblom, M Arthur Moseley, John P Dekker, Anthony F Suffredini
BACKGROUND: Rapid identification of respiratory pathogens may facilitate targeted antimicrobial therapy. Direct identification of bacteria in bronchoalveolar lavage (BAL) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is confounded by interfering substances. We describe a method to identify unique peptide markers of 5 gram-negative bacteria by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for direct pathogen identification in BAL. METHODS: In silico translation and digestion were performed on 14-25 whole genomes representing strains of Acinetobacter baumannii, Moraxella catarrhalis, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Klebsiella pneumoniae...
June 6, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28588122/patient-privacy-and-clinical-laboratory-data
#19
Jason Y Park, Toby C Cornish, Michael Hogarth, Brian R Jackson, Kristen B Rosati
No abstract text is available yet for this article.
June 6, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28588121/assessing-agreement-between-methods-of-measurement
#20
Douglas G Altman, J Martin Bland
No abstract text is available yet for this article.
June 6, 2017: Clinical Chemistry
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