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Clinical Chemistry

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https://www.readbyqxmd.com/read/29222341/spherical-nucleic-acids-adding-a-new-dimension-to-nucleic-acids-and-clinical-chemistry
#1
Chad A Mirkin, Sarah Hurst Petrosko
No abstract text is available yet for this article.
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29222340/evolution-of-materials-in-novel-point-of-care-diagnostics
#2
Rodrigo Chaves, Samuel K Sia
No abstract text is available yet for this article.
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29222339/the-biological-variation-data-critical-appraisal-checklist-a-standard-for-evaluating-studies-on-biological-variation
#3
Aasne K Aarsand, Thomas R Raas, Pilar Fernandez-Calle, Carmen Ricos, Jorge Díaz-Garzón, Niels Jonker, Carmen Perich, Elisabet González-Lao, Anna Carobene, Joana Minchinela, Abdurrahman Coŝkun, Margarita Simón, Virtudes Álvarez, William A Bartlett, Pilar Fernández-Fernández, Beatriz Boned, Federica Braga, Zoraida Corte, Berna Aslan, Sverre Sandberg
BACKGROUND: Concern has been raised about the quality of available biological variation (BV) estimates and the effect of their application in clinical practice. A European Federation of Clinical Chemistry and Laboratory Medicine Task and Finish Group has addressed this issue. The aim of this report is to (a) describe the Biological Variation Data Critical Appraisal Checklist (BIVAC), which verifies whether publications have included all essential elements that may impact the veracity of associated BV estimates, (b) use the BIVAC to critically appraise existing BV publications on enzymes, lipids, kidney, and diabetes-related measurands, and (c) apply metaanalysis to deliver a global within-subject BV (CVI) estimate for alanine aminotransferase (ALT)...
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29222338/blood-sample-transportation-by-pneumatic-transportation-systems-a-systematic-literature-review
#4
REVIEW
Mads Nybo, Merete E Lund, Kjell Titlestad, Christian U Maegaard
BACKGROUND: Pneumatic transportation systems (PTSs) are increasingly used for transportation of blood samples to the core laboratory. Many studies have investigated the impact of these systems on different types of analyses, but to elucidate whether PTSs in general are safe for transportation of blood samples, existing literature on the subject was systematically assessed. METHODS: A systematic literature review was conducted following the preferred reporting items for systematic reviews and metaanalyses (PRISMA) Statement guidelines to gather studies investigating the impact of PTS on analyses in blood samples...
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29222337/menopausal-hormone-therapy-and-cardiovascular-disease-unraveling-the-role-of-age-and-time-since-menopause-onset
#5
Shilpa N Bhupathiraju, Meir J Stampfer
No abstract text is available yet for this article.
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29208661/plasma-steroid-metabolome-for-diagnosis-and-subtyping-patients-with-cushing-syndrome
#6
Graeme Eisenhofer, Jimmy Masjkur, Mirko Peitzsch, Guido Di Dalmazi, Martin Bidlingmaier, Matthias Grüber, Julia Fazel, Andrea Osswald, Felix Beuschlein, Martin Reincke
BACKGROUND: Diagnosis of Cushing syndrome requires a multistep process that includes verification of hypercortisolism followed by identification of the cause of adrenocortical hyperfunction. This study assessed whether pituitary, ectopic, and adrenal subtypes of Cushing syndrome were characterized by distinct plasma steroid profiles that might assist diagnosis. METHODS: In this retrospective cross-sectional study, mass spectrometric measurements of a panel of 15 plasma steroids were applied to 222 patients tested for Cushing syndrome...
December 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29208660/dynamics-of-clinically-important-proteins-measuring-turnover-of-drug-targets-and-biomarkers
#7
EDITORIAL
N Leigh Anderson
No abstract text is available yet for this article.
December 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29208659/rapid-diagnosis-of-tick-borne-illnesses-by-use-of-one-step-isothermal-nucleic-acid-amplification-and-bio-optical-sensor-detection
#8
Ji Yeun Kim, Bonhan Koo, ChoongEun Jin, Min Chul Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Shin, Sung-Han Kim
BACKGROUND: Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the most common tick-borne illnesses in South Korea. Early differentiation of SFTS from scrub typhus in emergency departments is essential but difficult because of their overlapping epidemiology, shared risk factors, and similar clinical manifestations. METHODS: We compared the diagnostic performance of one-step isothermal nucleic acid amplification with bio-optical sensor detection (iNAD) under isothermal conditions, which is rapid (20-30 min), with that of real-time PCR, in patients with a confirmed tick-borne illness...
December 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29208658/unbiased-approach-to-counteract-upward-drift-in-cerebrospinal-fluid-amyloid-%C3%AE-1-42-analysis-results
#9
Betty M Tijms, Eline A J Willemse, Marissa D Zwan, Sandra D Mulder, Pieter Jelle Visser, Bart N M van Berckel, Wiesje M van der Flier, Philip Scheltens, Charlotte E Teunissen
BACKGROUND: Low cerebrospinal fluid (CSF) amyloid-β 1-42 (Aβ 1-42) concentrations indicate amyloid plaque accumulation in the brain, a pathological hallmark of Alzheimer disease (AD). Innotest assay values of Aβ 1-42 have gradually increased over the past 2 decades, which might lead to misclassification of AD when a single cutpoint for abnormality is used. We propose an unbiased approach to statistically correct for drift. METHODS: We determined year-specific cutpoints with Gaussian mixture modeling, based on the cross-section of bimodal distributions of Aβ 1-42 concentrations in 4397 memory clinic patients...
December 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29203475/hdl-particle-measurement-comparison-of-5-methods
#10
Robert Matera, Katalin V Horvath, Hari Nair, Ernst J Schaefer, Bela F Asztalos
BACKGROUND: HDL cell cholesterol efflux capacity has been documented as superior to HDL cholesterol (HDL-C) in predicting cardiovascular disease risk. HDL functions relate to its composition. Compositional assays are easier to perform and standardize than functional tests and are more practical for routine testing. Our goal was to compare measurements of HDL particles by 5 different separation methods. METHODS: HDL subfractions were measured in 98 samples using vertical auto profiling (VAP), ion mobility (IM), nuclear magnetic resonance (NMR), native 2-dimensional gel electrophoresis (2D-PAGE), and pre-β1-ELISA...
December 4, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29203474/skyline-performs-as-well-as-vendor-software-in-the-quantitative-analysis-of-serum-25-hydroxy-vitamin-d-and-vitamin-d-binding-globulin
#11
LETTER
Clark M Henderson, Nicholas J Shulman, Brendan MacLean, Michael J MacCoss, Andrew N Hoofnagle
No abstract text is available yet for this article.
December 4, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29187356/dairy-consumption-and-body-mass-index-among-adults-mendelian-randomization-analysis-of-184802-individuals-from-25-studies
#12
(no author information available yet)
BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined. METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study...
November 29, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29187355/state-of-the-science-in-dried-blood-spots
#13
REVIEW
Jeffrey D Freeman, Lori M Rosman, Jeremy D Ratcliff, Paul T Strickland, David R Graham, Ellen K Silbergeld
BACKGROUND: Advancements in the quality and availability of highly sensitive analytical instrumentation and methodologies have led to increased interest in the use of microsamples. Among microsamples, dried blood spots (DBS) are the most well-known. Although there have been a variety of review papers published on DBS, there has been no attempt at describing the full range of analytes measurable in DBS, or any systematic approach published for characterizing the strengths and weaknesses associated with adoption of DBS analyses...
November 29, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29187354/lactase-persistence-and-body-mass-index-the-contribution-of-mendelian-randomization
#14
EDITORIAL
Fernando Pires Hartwig, George Davey Smith
No abstract text is available yet for this article.
November 29, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29183890/planning-statistical-quality-control-to-minimize-patient-risk-it-s-about-time
#15
EDITORIAL
Curtis A Parvin
No abstract text is available yet for this article.
November 28, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29167194/cardiac-troponin-t-increase-in-patients-with-acute-ischemic-stroke-with-and-without-cancer
#16
LETTER
Kashif Waqar Faiz, Gunnar Einvik, Pål Haugar Brekke, Torbjørn Omland
No abstract text is available yet for this article.
November 22, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29162562/metabolic-effects-of-bariatric-surgery
#17
REVIEW
Piriyah Sinclair, Neil Docherty, Carel W le Roux
BACKGROUND: Obesity can be defined as a chronic subcortical brain disease, as there is an important neurophysiological component to its etiology based on changes in the functioning of those areas of the brain controlling food intake and reward. Extensive metabolic changes accompany bariatric surgery-based treatment of obesity. Consequently, the term "metabolic" surgery is being increasingly adopted in relation to the beneficial effects these procedures have on chronic diseases like type 2 diabetes...
November 21, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29158254/weight-history-and-subclinical-myocardial-damage
#18
Chiadi E Ndumele, Laura Cobb, Mariana Lazo, Natalie A Bello, Amil Shah, Vijay Nambi, Roger S Blumenthal, Gary Gerstenblith, Scott D Solomon, Christie M Ballantyne, Elizabeth Selvin, Josef Coresh
BACKGROUND: Excess weight is associated with subclinical myocardial damage, as reflected by high-sensitivity cardiac troponin T (hs-cTnT) concentrations, which portends high heart failure risk. However, the association between weight history and myocardial damage is unknown. METHODS: We evaluated 9062 Atherosclerosis Risk in Communities (ARIC) visit 4 (1996-1999) participants with a body mass index (BMI) ≥ 18.5 kg/m(2) and no previous cardiovascular disease. We cross-tabulated visit 4 ("current") BMI categories of normal weight, overweight, and obese with those at visit 1 (1987-1989) and with BMI categories calculated from self-reported weight at age 25 years...
November 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29158253/the-burden-of-a-heavy-heart
#19
EDITORIAL
Pratyaksh K Srivastava, Brendan M Everett
No abstract text is available yet for this article.
November 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29158252/food-addiction-high-glycemic-index-carbohydrates-and-obesity
#20
REVIEW
Belinda Lennerz, Jochen K Lennerz
BACKGROUND: Treatment success in obesity remains low, and recently food addiction has been delineated as an underlying etiologic factor with therapeutic relevance. Specifically, current treatment focuses on reduced food intake and increase of physical activity, whereas interventions for addiction encompass behavioral therapy, abstinence, and environmental interventions such as taxation, restrictions on advertising, and regulation of school menus. CONTENT: Here, we reviewed the pertinent literature on food addiction with a specific focus on the role of high-glycemic-index carbohydrates in triggering addictive symptoms...
November 20, 2017: Clinical Chemistry
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