journal
MENU ▼
Read by QxMD icon Read
search

Clinical Chemistry

journal
https://www.readbyqxmd.com/read/27903617/biomarkers-for-cardiovascular-screening-progress-or-pass%C3%A3
#1
Brendan M Everett, Paul M Ridker
No abstract text is available yet for this article.
November 30, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27903616/immediate-rule-out-of-acute-myocardial-infarction-using-electrocardiogram-and-baseline-high-sensitivity-troponin-i
#2
Johannes Tobias Neumann, Nils Arne Sörensen, Francisco Ojeda, Tjark Schwemer, Jonas Lehmacher, Saskia Gönner, Nikolas Jarsetz, Till Keller, Sarina Schaefer, Thomas Renné, Ulf Landmesser, Peter Clemmensen, Nataliya Makarova, Renate B Schnabel, Tanja Zeller, Mahir Karakas, John W Pickering, Martin Than, William Parsonage, Jaimi Greenslade, Louise Cullen, Dirk Westermann, Stefan Blankenberg
AIMS: Serial measurements of high-sensitivity troponin are used to rule out acute myocardial infarction (AMI) with an assay specific cutoff at the 99th percentile. Here, we evaluated the performance of a single admission troponin with a lower cutoff combined with a low risk electrocardiogram (ECG) to rule out AMI. METHODS: Troponin I measured with a high-sensitivity assay (hs-TnI) was determined at admission in 1040 patients presenting with suspected AMI (BACC study)...
November 30, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27895086/the-use-of-sex-specific-cutpoints-for-high-sensitivity-cardiac-troponin-assays
#3
Louise A Cullen, Nicholas L Mills
No abstract text is available yet for this article.
November 28, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27895085/potential-concerns-regarding-the-use-of-sex-specific-cutpoints-for-high-sensitivity-troponin-assays
#4
Evangelos Giannitsis
No abstract text is available yet for this article.
November 28, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27881450/glial-fibrillary-acidic-protein-serum-levels-distinguish-between-intracerebral-hemorrhage-and-cerebral-ischemia-in-the-early-phase-of-stroke
#5
Sebastian Luger, Jens Witsch, Andreas Dietz, Gerhard F Hamann, Jens Minnerup, Hauke Schneider, Matthias Sitzer, Katja E Wartenberg, Marion Niessner, Christian Foerch
BACKGROUND: Recent studies have suggested that glial fibrillary acidic protein (GFAP) serum concentrations distinguish between intracerebral hemorrhage (ICH) and ischemic stroke (IS) shortly after symptom onset. In this prospective multicenter trial we validated GFAP in an independent patient cohort and assessed the quantitative relationship between GFAP release, bleeding size, and localization. METHODS: We included patients with a persistent neurological deficit (NIH Stroke Scale ≥4) suggestive of stroke within 6 h of symptom onset...
November 23, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27879324/review-the-changing-face-of-hdl-and-the-best-way-to-measure-it
#6
REVIEW
Sotirios K Karathanasis, Lita A Freeman, Scott M Gordon, Alan T Remaley
BACKGROUND: HDL cholesterol (HDL-C) is a commonly used lipid biomarker for assessing cardiovascular health. While a central focus has been placed on the role of HDL in the reverse cholesterol transport (RCT) process, our appreciation for the other cardioprotective properties of HDL continues to expand with further investigation into the structure and function of HDL and its specific subfractions. The development of novel assays is empowering the research community to assess different aspects of HDL function, which at some point may evolve into new diagnostic tests...
November 22, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27879323/issues-and-challenges-in-diagnostic-sequencing-for-inherited-cardiac-conditions
#7
REVIEW
Roddy Walsh, Stuart A Cook
BACKGROUND: Inherited cardiac conditions are a relatively common group of Mendelian diseases associated with ill health and death, often in the young. Research into the genetic causes of these conditions has enabled confirmatory and predictive diagnostic sequencing to become an integral part of the clinical management of inherited cardiomyopathies, arrhythmias, aortopathies, and dyslipidemias. CONTENT: Currently, the principle benefit of clinical genetic testing is the cascade screening of family members of patients with a pathogenic variant, enabling targeted follow up of presymptomatic genotype-positive individuals and discharge of genotype-negative individuals to health...
November 22, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27872083/biomarkers-and-genetics-in-peripheral-artery-disease
#8
REVIEW
Surovi Hazarika, Brian H Annex
BACKGROUND: Peripheral artery disease (PAD) is highly prevalent and there is considerable diversity in the initial clinical manifestation and disease progression among individuals. Currently, there is no ideal biomarker to screen for PAD, to risk stratify patients with PAD, or to monitor therapeutic response to revascularization procedures. Advances in human genetics have markedly enhanced the ability to develop novel diagnostic and therapeutic approaches across a host of human diseases, but such developments in the field of PAD are lagging...
November 21, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27872082/evolving-use-of-natriuretic-peptides-as-part-of-strategies-for-heart-failure-prevention
#9
REVIEW
Ken McDonald, Mark Wilkinson
BACKGROUND: Heart failure (HF) remains one of the major cardiovascular challenges to the Western world. Once established, HF is characterized by compromised life expectancy and quality of life with considerable dependence on hospital care for episodic clinical deterioration. Much is understood about the risk factors that predispose to the development of HF. With such a broad range of factors, it is clear that there is a large population at risk, potentially in excess of 25% of the adult population...
November 21, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864389/troponin-autoantibodies-from-assay-interferent-to-mediator-of-cardiotoxicity
#10
EDITORIAL
Jason Y Park, Allan S Jaffe
No abstract text is available yet for this article.
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864388/payer-perspectives-on-coverage-of-biomarker-testing-in-cardiovascular-disease
#11
Sean R Tunis, Donna A Messner
No abstract text is available yet for this article.
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864387/increased-trimethylamine-n-oxide-portends-high-mortality-risk-independent-of-glycemic-control-in-patients-with-type-2-diabetes-mellitus
#12
W H Wilson Tang, Zeneng Wang, Xinmin S Li, Yiying Fan, Daniel S Li, Yuping Wu, Stanley L Hazen
BACKGROUND: Recent studies show a mechanistic link between intestinal microbial metabolism of dietary phosphatidylcholine and coronary artery disease pathogenesis. Concentrations of a proatherogenic gut microbe-generated metabolite, trimethylamine N-oxide (TMAO), predict increased incident cardiovascular disease risks in multiple cohorts. TMAO concentrations are increased in patients with type 2 diabetes mellitus (T2DM), but their prognostic value and relation to glycemic control are unclear...
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864386/a-roadmap-to-successful-clinical-proteomics
#13
Ian Wright, Jennifer E Van Eyk
No abstract text is available yet for this article.
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864385/one-shot-to-rule-out-does-the-limit-of-detection-of-a-high-sensitivity-troponin-assay-hit-the-mark
#14
EDITORIAL
Richard Body, Charles Reynard
No abstract text is available yet for this article.
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864384/reconciling-systems-for-acute-myocardial-infarction-definition-and-coding-classification
#15
EDITORIAL
L Kristin Newby
No abstract text is available yet for this article.
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864383/use-of-pharmacogenetic-information-in-the-treatment-of-cardiovascular-disease
#16
REVIEW
Kevin Friede, Josephine Li, Deepak Voora
BACKGROUND: In 1964, Robert A. O'Reilly's research group identified members of a family who required remarkably high warfarin doses (up to 145 mg/day, 20 times the average dose) to achieve appropriate anticoagulation. Since this time, pharmacogenetics has become a mainstay of cardiovascular science, and genetic variants have been implicated in several fundamental classes of medications used in cardiovascular medicine. CONTENT: In this review, we discuss genetic variants that affect drug response to 3 classes of cardiovascular drugs: statins, platelet P2Y12 inhibitors, and anticoagulants...
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27815309/the-role-of-emerging-biomarkers-in-unraveling-the-complex-biology-underlying-associations-between-hdl-cholesterol-and-cardiovascular-diseases
#17
EDITORIAL
Aeron M Small, Nehal N Mehta, Daniel J Rader
No abstract text is available yet for this article.
November 4, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27815308/anti-cardiac-troponin-autoantibodies-are-specific-to-the-conformational-epitopes-formed-by-cardiac-troponin-i-and-troponin-t-in-the-ternary-troponin-complex
#18
Alexandra V Vylegzhanina, Alexander E Kogan, Ivan A Katrukha, Olga V Antipova, Andrey N Kara, Anastasia V Bereznikova, Ekaterina V Koshkina, Alexey G Katrukha
BACKGROUND: Autoantibodies to cardiac troponins (TnAAbs) could negatively affect cardiac troponin I (cTnI) measurements by TnAAbs-sensitive immunoassays. We investigated the epitope specificity of TnAAbs and its influence on cTnI immunodetection in patients with acute myocardial infarction (AMI). METHODS: The specificity of TnAAbs was studied in immunoassays and gel-filtration experiments. The influence of TnAAbs on endogenous troponin measurements was studied in 35 plasma samples from 15 patients with AMI...
November 4, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27815307/state-of-the-art-blood-biomarkers-for-risk-stratification-in-patients-with-stable-ischemic-heart-disease
#19
REVIEW
Torbjørn Omland, Harvey D White
BACKGROUND: Multiple circulating biomarkers have been associated with the incidence of cardiovascular events and proposed as potential tools for risk stratification in stable ischemic heart disease (IHD), yet current guidelines do not make any firm recommendations concerning the use of biomarkers for risk stratification in this setting. This state-of-the-art review provides an overview of biomarkers for risk stratification in stable IHD. CONTENT: Circulating biomarkers associated with the risk of cardiovascular events in patients with stable IHD reflect different pathophysiological processes, including myocardial injury, myocardial stress and remodeling, metabolic status, vascular inflammation, and oxidative stress...
November 4, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27811210/a-novel-protein-glycan-derived-inflammation-biomarker-independently-predicts-cardiovascular-disease-and-modifies-the-association-of-hdl-subclasses-with-mortality
#20
Robert W McGarrah, Jacob P Kelly, Damian M Craig, Carol Haynes, Ryan C Jessee, Kim M Huffman, William E Kraus, Svati H Shah
BACKGROUND: Evidence suggests that systemic inflammation may adversely impact HDL function. In this study we sought to evaluate the independent and incremental predictive performance of glycoprotein acetylation (GlycA)-a novel serum inflammatory biomarker that is an aggregate measure of enzymatically glycosylated acute phase proteins-and HDL subclasses on adverse events in a retrospective observational study of a secondary prevention population and to understand a priori defined potential interactions between GlycA and HDL subclasses...
November 3, 2016: Clinical Chemistry
journal
journal
31614
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"