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Hypertension in Pregnancy

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https://www.readbyqxmd.com/read/29733777/morphological-and-structural-changes-of-umbilical-veins-and-clinical-significance-in-preeclampsia
#1
Yonghong Lan, Zhi Yang, Mingmei Huang, Zhigang Cui, Yaling Qi, Haiyan Niu
OBJECTIVE: Preeclampsia is a common complication of pregnancy that is characterized by high blood pressure. Preeclampsia can have both negative maternal and fetal effects, including impaired fetal development from reduced placental perfusion. Because umbilical vessels provide fetal blood supply, morphological changes in these vessels can critically affect fetal function. This study investigated morphological and structural changes in umbilical veins from 17 controls and 19 preeclampsia cases...
May 7, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29714512/association-of-angiotensin-receptor-2-gene-polymorphisms-with-pregnancy-induced-hypertension-risk
#2
Chenyang Li, Weijun Peng, Heng Zhang, Weirong Yan
OBJECTIVES: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. METHODS: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk...
May 1, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29694251/cardiovascular-risk-after-preeclampsia-the-effect-of-communicating-risk-factors-on-intended-healthy-behavior
#3
Anouk Bokslag, Willemieke Kroeze, Christianne J M de Groot, Pim W Teunissen
OBJECTIVE: We studied the effect of communicating cardiovascular risk factors on intended healthy behavior in women with a history of preeclampsia or uncomplicated pregnancy. METHODS: Intention for healthy behavior was assessed before and after cardiovascular risk assessment. Changes were calculated for women with and without cardiovascular risk factors. RESULTS: In women with cardiovascular risk factors, the intention to quit smoking increased; whereas, intended healthy diet and sufficient exercise did not change...
April 25, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29658370/changes-in-endothelial-function-arterial-stiffness-and-blood-pressure-in-pregnant-women-after-consumption-of-high-flavanol-and-high-theobromine-chocolate-a-double-blind-randomized-clinical-trial
#4
Asma Babar, Emmanuel Bujold, Vicky Leblanc, Élise Lavoie-Lebel, Joalee Paquette, Laurent Bazinet, Simone Lemieux, Isabelle Marc, Belkacem Abdous, Sylvie Dodin
OBJECTIVES: The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS: 131 pregnant women considered at risk of preeclampsia based on uterine artery Doppler ultrasound were divided into two groups (HFHT or low flavanol and theobromine chocolate (LFLT)...
April 16, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29575956/relation-of-locus-1p13-rs646776-polymorphism-with-the-risk-of-preeclampsia
#5
Rana H Emam, Maivel H Ghattas, Noha M Mesbah, Dina M Abo-Elmatty, Eman T Mehanna
OBJECTIVE: This study aimed to assess the relation of locus 1p13 rs646776 (T/C) polymorphism with preeclampsia in Egyptian women. METHODS: The study included 100 healthy pregnant female subjects and 100 preeclampsia patients. The genotypes of the polymorphisms were assessed. Endothelin-1 level was determined in plasma. RESULTS: The major T allele of the 1p13.3 genomic region rs646776 polymorphism had a higher frequency in preeclampsia patients...
March 25, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29718786/association-between-serum-ca125-levels-in-preeclampsia-and-its-severity-among-women-in-lagos-south-west-nigeria
#6
Gbemisola E Osanyin, Kehinde S Okunade, Ayodeji Ayotunde Oluwole
BACKGROUND: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. AIM: This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29495906/safety-of-a-physical-therapy-protocol-for-women-with-preeclampsia-a-randomized-controlled-feasibility-trial
#7
Tawana Vicente Bertagnolli, Michelle de Souza Rangel Machado, Cristine Jorge Homsi Ferreira, Jackeline de Souza Rangel Machado, Geraldo Duarte, Ricardo Carvalho Cavalli
OBJECTIVE: To assess the feasibility and safety of a physiotherapy protocol applied to pregnant women with preeclampsia. METHODS: Randomized, controlled, single-blind feasibility study, with 24 hospitalized pregnant women with preeclampsia. The intervention group received one session of the physiotherapy. The control group remained under the routine care of the hospital. The primary outcomes were Doppler velocimetry, cardiotocography, and maternal-fetal hemodynamics...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29308696/early-pregnancy-protein-multiplex-screening-reflects-circulating-and-urinary-divergences-associated-with-the-development-of-preeclampsia
#8
Margarita L Martinez-Fierro, Claudia Castruita-De La Rosa, Idalia Garza-Veloz, Rosa M Cardiel-Hernandez, Marcela A Espinoza-Juarez, Ivan Delgado-Enciso, Maria E Castañeda-Lopez, Edith Cardenas-Vargas, Fabiola Trejo-Vázquez, Elma I Sotelo-Ham, Rodrigo Castañeda-Miranda, Miguel A Cid-Baez, Jose M Ortiz-Rodriguez, Luis O Solis-Sanchez, Angelica Garcia Aviles, Yolanda Ortiz-Castro
BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. OBJECTIVE: To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. METHODS: We performed a nested cohort case-control study of pregnant women...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29291357/associations-of-hypertensive-disorders-of-pregnancy-and-outcomes-of-labor-induction-with-prostaglandin-vaginal-inserts
#9
Lili Sheibani, Kyle Raymond, Olof Rugarn, Deborah A Wing
OBJECTIVE: To evaluate the association between hypertensive (HTNsive) disorders of pregnancy and outcomes of labor induction, in two cohorts of women induced with either misoprostol vaginal insert (MVI) or dinoprostone vaginal insert (DVI). STUDY DESIGN: This investigation was a post-hoc analysis of data from three Phase II and III, multi-center, double blind, randomized controlled trials of women induced with identical efficacy endpoints. A competing risk framework investigated the association between HTNsive disorders of pregnancy and the time-to-event endpoints of onset of active labor and vaginal delivery...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29172779/the-effect-of-magnesium-sulfate-on-gene-expression-in-maternal-microvascular-endothelial-cells
#10
Dennis K Lee, Anindita Sengupta, Ori Nevo
Preeclampsia is a severe complication of pregnancy associated with maternal and fetal morbidity and mortality. To date, magnesium sulfate remains the preferred method of treatment used to reduce the development of eclampsia. Our aim was to investigate the effects of magnesium sulfate on the expression of genes involved with endothelial function in maternal microvascular endothelial cells from both normal and preeclamptic pregnancies. Primary cells from normal pregnancies treated with 80 mg/L magnesium sulfate for 6 h revealed an overall trend of increased expression of angiogenic and vasopressor-related factors by qPCR analyses...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29157041/relation-with-postpartum-maternal-morbidity-of-different-types-of-anesthesia-in-preeclamptic-patients
#11
Hasan Ulubaşoğlu, Kadir Bakay, Davut Güven
OBJECTIVE: The aim of this study is to investigate the effect of different anesthesia types administered to patients with preeclampsia on postoperative maternal morbidities. METHODS: Medical records of pregnant women complicated with preeclampsia delivered by cesarean from January 2010 to December 2016 in our clinic were retrospectively reviewed. RESULTS: There was not a statistically significant difference between patients receiving spinal anesthesia and general anesthesia in terms of additional parenteral analgesic requirement at postoperative period (p = 0...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29157033/alteration-in-methylation-level-at-differential-methylated-regions-of-mest-and-dlk1-in-fetus-of-preeclampsia
#12
Xiaoqing Wang, Liuxia Wan, Xiaoling Weng, Jiamin Xie, Aiping Zhang, Yun Liu, Minyue Dong
OBJECTIVES: Offspring born to preeclamptic women are at high risk for metabolic diseases in later life, but the mechanisms are not known. The purposes of the current investigation were to clarify the changes in DNA methylation at MEST and DLK1 DMRs in fetus of preeclampsia and to explore the possible mechanisms behind the high risk of adult diseases in the offspring of preeclampsia. METHODS: Fetal lymphocytes were isolated from umbilical cord blood of 78 women with preeclampsia and 95 women with normal pregnancy...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29140734/preeclampsia-knowledge-among-women-in-utah
#13
Jessica Wilkinson, Gene Cole
BACKGROUND: Despite the benefits of preeclampsia (PE) education in improving health outcomes, little is known about how often healthcare providers in Utah include PE in prenatal education or how much information women retain. As such, the purpose of this study was to explore PE awareness among mothers in Utah and inquire how often PE is included in prenatal education. Factors associated with PE knowledge were also investigated. METHODS: A cross-sectional survey was conducted...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29135310/adamts-1-4-12-and-13-levels-in-maternal-blood-cord-blood-and-placenta-in-preeclampsia
#14
Müberra Namlı Kalem, Ziya Kalem, Tuncay Yüce, Feride Soylemez
The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. Based on the immunohistochemistry (IHC) results, ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29131741/editorial-board-page-eov
#15
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29125378/type-of-obstetric-anesthesia-administered-and-complications-in-women-with-preeclampsia-in-low-and-middle-income-countries-a-systematic-review
#16
Soha Sobhy, Kuhan Dharmarajah, David Arroyo-Manzano, Ramesan Navanatnarajah, James Noblet, Javier Zamora, Shakila Thangaratinam
BACKGROUND: Delivery is often expedited with cesarean section, necessitating anesthesia, to prevent complications in women with preeclampsia. Anesthesia-associated risks in these women from low- and middle-income countries (LMICs) are not known. METHODS: We searched major databases (until February 2017) for studies on general vs. regional anesthesia in women with preeclampsia. We summarized the association between outcomes and type of anesthesia using a random effects model and reported as odds ratio (OR) with 95% confidence intervals (95% CIs)...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29115889/circulating-fetal-and-total-cell-free-dna-and-shla-g-in-black-south-african-women-with-gestational-hypertension-and-pre-eclampsia
#17
Simeon Eche, Irene Mackraj, Jagidesa Moodley
OBJECTIVE: Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia. METHODS: Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive patients using real-time qPCR. Soluble HLAG was measured by enzyme-linked immune-sorbent assay. RESULTS: Serum fetal and total cfDNA levels were higher in pre-eclampsia compared with the controls and gestational hypertensives (p < 0...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29058512/maternal-serum-autotaxin-levels-in-early-and-late-onset-preeclampsia
#18
Hakan Erenel, Nevin Yilmaz, Tayfur Cift, Berk Bulut, Isik Sozen, Berna Aslan Cetin, Altay Gezer, Hakan Ekmekci, Baris Kaya, Abdullah Tuten
PURPOSE: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. METHODS: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29058492/association-between-the-soluble-epoxide-hydrolase-gene-and-preeclampsia
#19
Ismail Sari, Hatice Pinarbasi, Ergun Pinarbasi, Caglar Yildiz
OBJECTIVE: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women. METHODS: K55R polymorphism and methylation level of the EPHX2 promoter were determined by the real-time PCR using double-dye hydrolysis probes and methylation-sensitive high-resolution melting analysis, respectively. RESULTS: The presence of the K55R polymorphism was significantly higher in cases (28...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29039998/fn1-fos-and-itga5-induce-preeclampsia-abnormal-expression-and-methylation
#20
Mei Zhao, Lin Li, Xiumei Yang, Jianying Cui, Hong Li
OBJECTIVE: As a frequent hypertensive disorder in pregnancy, preeclampsia causes 15% of all preterm deliveries. This study aims to understand its mechanism via analyzing gene expression and methylation data. METHODS: Human gene expression microarray data (GSE73374) and corresponding DNA methylation microarray data (GSE73375) of preeclamptic placental tissues (n = 19) and normotensive placental tissues (n = 17) were obtained from the Gene Expression Omnibus. Differentially expressed genes (DEGs), differentially methylated regions (DMRs) and CpG islands (DMIs) were identified and compared...
November 2017: Hypertension in Pregnancy
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