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Hypertension in Pregnancy

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https://www.readbyqxmd.com/read/28102720/do-racial-differences-exist-in-the-association-between-pregnancy-induced-hypertension-and-breast-cancer-risk
#1
Li-Te Lin, Li-Yu Hu, Pei-Ling Tang, Kuan-Hao Tsui, Jiin-Tsuey Cheng, Wei-Chun Huang, Hong-Tai Chang
BACKGROUND: Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we designed a retrospective population-based cohort study to assess the relationship between PIH and subsequent risk for breast cancer in Taiwan. METHODS: Patients with newly diagnosed PIH were selected from the Taiwan National Health Insurance Research Database (NHIRD), and a 1:4 matched cohort of women without PIH based on age and the year of delivery was randomly selected from the same database as the comparison group...
January 19, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28067578/relationship-between-hypoxia-and-downstream-pathogenic-pathways-in-preeclampsia
#2
Henri Augusto Korkes, Leandro De Oliveira, Nelson Sass, Saira Salahuddin, S Ananth Karumanchi, Augustine Rajakumar
Defects in angiogenesis and mitochondrial function in the placenta contribute to the pathogenesis of preeclampsia; however upstream regulators of these pathways are not known. It has been argued that placental hypoxia secondary to abnormal spiral artery remodeling may play a causal role in the angiogenic and mitochondrial abnormalities noted in preeclampsia. The aim of this study was to evaluate the relationship between hypoxia-inducible factor-1α (HIF-1α) ¸ a surrogate of hypoxia, and soluble fms-tyrosine kinase 1 (sFlt1), a circulating anti-angiogenic factor, and microRNA 210 (miR-210), a microRNA that regulates mitochondrial function, in human placentas from preeclamptic and non-hypertensive pregnancies...
January 9, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28001450/sdf-1-cxcl12-and-cxcr4-gene-variants-and-elevated-serum-sdf-1-levels-are-associated-with-preeclampsia
#3
Savas Karakus, Binnur Bagci, Gokhan Bagci, Enver Sancakdar, Caglar Yildiz, Ozlem Akkar, Ali Cetin
OBJECTIVE: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). METHODS: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level. RESULTS: For SDF-1 3'A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0...
December 21, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28001098/pre-eclampsia-and-risk-of-subsequent-hypertension-in-an-american-indian-population
#4
Lyle G Best, Laramie Lunday, Elisha Webster, Gilbert R Falcon, James R Beal
BACKGROUND AND OBJECTIVES: Pre-eclampsia (PE) shares a number of proposed pathophysiologic mechanisms related to those implicated in cardiovascular disease (CVD), such as endothelial dysfunction, inflammation, insulin resistance, and impaired renal regulation. PE has also been associated with subsequent hypertension, CVD, and related mortality in later life. METHODS: At follow-up, the four most recent blood pressures, body mass index (BMI), and use of hypertensive medications were recorded from clinic visits of 130 PE cases and 289 normal pregnancies...
December 21, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27858505/vascular-ultrasound-measures-before-pregnancy-and-pregnancy-complications-a-prospective-cohort-study
#5
Emily W Harville, Markus Juonala, Jorma S A Viikari, Mika Kähönen, Olli T Raitakari
: Supplemental data for this article can be accessed at Objectives: To examine the relationship between pre-pregnancy indicators of cardiovascular risk and pregnancy complications and outcomes. STUDY DESIGN: Data from 359 female participants in the Cardiovascular Risk in Young Finns Study were linked with the national birth registry. Flow-mediated dilatation (FMD; maximum change in the left brachial artery diameter after rest and hyperemia); carotid intima-media thickness (IMT); Young's elastic modulus (YEM); and carotid artery distensibility (Cdist) at the visit prior to the pregnancy were examined as predictors of hypertensive disorders, birthweight, and gestational age using multivariable linear regression with adjustment for confounders (age, BMI, smoking, and socioeconomic status)...
November 18, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835051/comparison-of-serum-selenium-levels-among-hypertensive-and-normotensive-pregnant-women
#6
Alíssia Cardoso da Silva, Sérgio Hofmeister Martins-Costa, Edimárlei Gonsales Valério, José Geraldo Lopes Ramos
OBJECTIVE: To correlate serum selenium levels with hypertensive disorders of pregnancy (HDP) in a selected population and evaluate this mineral as a possible protective factor. METHODS: This case-control study included 32 normotensive, 20 hypertensive (chronic and gestational hypertension), and 38 preeclamptic pregnant women. All patients were recruited from antenatal or obstetric admissions of a tertiary hospital in Brazil. Serum selenium was measured at the time of inclusion...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835048/furosemide-in-postpartum-management-of-severe-preeclampsia-a-randomized-controlled-trial
#7
P Veena, Lakshmideepthi Perivela, S Soundara Raghavan
BACKGROUND: Hypertension in the postpartum period is a common phenomenon and is often a cause for concern. Following delivery, fluid that has been sequestered in the extravascular space is mobilized, producing a large auto-infusion of fluid from the extravascular to the intravascular compartment. As a result of this fluid mobilization process, there is an increase in central venous pressure and pulmonary capillary wedge pressure, which might favor the development of pulmonary edema. Thus, diuretics logically might be a better choice as antihypertensive medication in such a scenario...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835046/identifying-mirna-regulatory-mechanisms-in-preeclampsia-by-systems-biology-approaches
#8
Orsolya Biró, Bálint Nagy, János Rigó
BACKGROUND: Preeclampsia (PE) is the major cause of maternal and fetal morbidity and mortality, affecting 3-8% of all pregnancies around the globe. miRNAs are small, noncoding RNA molecules, which negatively regulate gene expression. Abnormally expressed miRNAs contribute to pregnancy complications such as PE. The aim of our study was to find possible regulatory mechanisms by system biology approaches, which are connected to the pathogenesis of PE. METHODS: We integrated publicly available miRNA and gene expression profiles and created a network from the significant miRNA-mRNA pairs with the help of MAGIA and Cytoscape softwares...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835040/developing-a-new-algorithm-for-first-and-second-trimester-preeclampsia-screening-in-twin-pregnancies
#9
Ron Maymon, Alla Trahtenherts, Ran Svirsky, Yaakov Melcer, Liora Madar-Shapiro, Esther Klog, Hamutal Meiri, Howard Cuckle
OBJECTIVES: Construct a new preeclampsia predicting algorithm in twins. METHODS: Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk factors. RESULTS: The cohort included 9 PE (18 samples) and 96 unaffected cases (175 samples) twin pregnant women. The algorithm constructed of PlGF, PAPP-A, PP13, Doppler UTPI, and MAP with prior risk factors generated an area under the curve of 0...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835036/increased-circulating-th22-cells-correlated-with-th17-cells-in-patients-with-severe-preeclampsia
#10
Zhan Zhang, Hui Liu, Ying Shi, Na Xu, Yuanyuan Wang, Aiping Li, Wanyu Song
OBJECTIVE: We aimed to investigate Th22 cells and their association with Th17 and Treg cells in the etiology of severe preeclampsia (sPE). METHODS: Thirty sPE patients and 30 healthy pregnant women were recruited in this study. The percentages of Th17, Th22, and regulatory T cells (Tregs) in the peripheral blood were measured by flow cytometry. ELISA was used to measure the plasma concentrations of interleukin (IL)-17, IL-22, and IL-10. RESULTS: The percentages of Th17 and Th22 cells and the plasma concentrations of IL-17 and IL-22 were significantly increased in sPE patients along with a decreased percentage of Treg cells and a decreased plasma IL-10 concentration...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835035/the-effect-of-healthy-pregnant-plasma-and-preeclamptic-plasma-on-the-phagocytosis-index-of-neutrophil-granulocytes-and-monocytes-of-nonpregnant-women
#11
Rudolf Lampé, Ágnes Kövér, Sándor Szűcs, László Pál, Ervin Árnyas, Robert Póka
OBJECTIVE: Phagocyte function of neutrophil granulocytes and monocytes is decreased in healthy pregnancy and further decreased in preeclampsia. The cause of the declined function is unknown. Decreased phagocyte function can lead to the higher infection rate in healthy pregnancy and may also be responsible for the increased susceptibility to infections and high trophoblast concentration in preeclampsia. The aim of this study is to examine the phagocyte function of neutrophil granulocytes and monocytes...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835033/travel-distance-to-prenatal-care-and-high-blood-pressure-during-pregnancy
#12
Lu Shi, Kara E MacLeod, Donglan Zhang, Fan Wang, Margaret Shin Chao
OBJECTIVE: To assess whether poor geographic accessibility to prenatal care, as indicated by long distance trips to prenatal care, produced high blood pressure (HPB) during pregnancy. METHODS: Using the 2007 Los Angeles Mommy and Baby Study for women without hypertension prior to pregnancy (n = 3405), we compared self-reported HBP by travel distance to prenatal care controlling for age, race/ethnicity, marital status, education, household income, weight status, and physical activity...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835032/dietary-sodium-and-potassium-intake-were-associated-with-hypertension-kidney-damage-and-adverse-perinatal-outcome-in-pregnant-women-with-preeclampsia
#13
Zehra Vural Yılmaz, Elif Akkaş, Gülenay Gençosmanoğlu Türkmen, Özgür Kara, Aykan Yücel, Dilek Uygur
OBJECTIVES: In this study, we hypothesized that dietary salt and potassium intake may be related with blood pressure, kidney damage and perinatal outcome in pregnants with preeclampsia (PE). METHODS: In total, 200 women (50 control women with healthy pregnancy, 150 women with PE) were recruited for the study. Daily salt and potassium intake was estimated based on calculation of 24-hour urinary sodium U[Na+] and potassium U[K+] excretion. U[Na+]/[K+] was calculated by dividing U[Na+] by U[K+]...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27835031/cardiogenic-shock-in-pregnancy-analysis-from-the-national-inpatient-sample
#14
Jennifer Banayan, Sarosh Rana, Ariel Mueller, Avery Tung, Hadi Ramadan, Zoltan Arany, Junaid Nizamuddin, Victor Novack, Barbara Scavone, Samuel M Brown, Sajid Shahul
OBJECTIVE: Cardiogenic shock (CS) may occur during pregnancy and dramatically worsen peripartum outcomes. METHODS: We analyzed the National Inpatient Sample from 2002 to 2013 to describe the incidence of, risk factors for and outcomes of CS during pregnancy. RESULTS: Of the 53,794,192 hospitalizations analyzed, 2044 were complicated by CS. The mortality rate in peripartum women with CS was 18.81% versus 0.02% without. It occurs more often during postpartum (58...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27834501/use-of-serum-and-urinary-soluble-sflt-1-and-plgf-in-the-diagnosis-of-preeclampsia
#15
Ping Tang, Jing Xu, Bao-Jun Xie, Qi-Mei Wang
OBJECTIVE: Preeclampsia (PE) is a disorder of pregnancy marked by hypertension and proteinuria with no known treatment aside from pregnancy termination. The pathogenesis of PE is poorly understood, but is thought to originate in the placenta. We assessed the value of measuring serum and urinary soluble deformylase-like tyrosine kinase receptor 1 (sFlt-1), a known target of placental factors, and placental growth factor (PLGF), a key placental signaling molecule, in the diagnosis of PE...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28195751/editorial-board-eov
#16
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27647153/increased-prenatal-blood-manganese-may-induce-gestational-blood-pressure
#17
Mohsen Vigeh, Emiko Nishioka, Kazuhito Yokoyama, Katsumi Ohtani, Takehisa Matsukawa
OBJECTIVE: Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined. METHODS: To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined. RESULTS: Early pregnancy blood Mn was significantly (p < 0.05) correlated with blood pressure through gestation...
November 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27646972/association-between-comt-val158met-polymorphism-and-preeclampsia-in-the-chinese-han-population
#18
Xiaohua Zhao, Jingjing Liu, Cuisheng Zhao, Ping Ye, Jing Ji, Jingli Wang, Weiqing Song, Jine Xu, Shiguo Liu
OBJECTIVE: Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women. METHOD: A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR ...
November 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27624400/preeclampsia-with-and-without-intrauterine-growth-restriction-two-pathogenetically-different-entities
#19
Jelena Milosevic-Stevanovic, Miljan Krstic, Dragana Radovic-Janosevic, Milan Stefanovic, Vladimir Antic, Ivana Djordjevic
OBJECTIVE: The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS: A prospective case-control study included a study group consisting of 30 pregnant women with preeclampsia completed by cesarean section (CS), in 19 of whom preeclampsia was associated with IUGR, and in 11 it was not. The control group consisted of 20 healthy pregnant women delivered by elective CS...
November 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27599037/mom-cutoffs-for-variables-an-important-tool-for-multivariate-analysis-and-accurate-interpretation-of-preeclampsia-risk-in-high-risk-pregnancy-at-11-13-6-weeks-gestation
#20
Jyotsna Verma, Divya C Thomas, Geetu Jhingan, Ratna D Puri, I C Verma
OBJECTIVE: To determine the diagnostic accuracy of preeclampsia (PE) screening test offered in early pregnancy for the prediction of the risks for early-onset (requiring delivery <32 weeks gestation) and late-onset (requiring delivery ≥32 weeks gestation) disease. METHODS: In a retrospective study of 615 women with singleton pregnancy, the risk for PE was calculated by the combined effect of multiple variables: serum placental growth factor (PLGF) and pregnancy-associated plasma protein-A (PAPP-A), maternal age, parity, ethnicity, mean arterial pressure (MAP), body mass index (BMI), uterine artery-pulsatility index, and previous history of PE or hypertension (HT)...
November 2016: Hypertension in Pregnancy
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