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Hypertension in Pregnancy

Ahter Tanay Tayyar, Ahmet Tayyar, Sukran Kozali, Resul Karakus, Ahmet Eser, Cigdem Abide Yayla, Emel Tugce Yalcin, Ismail Dag, Mustafa Eroglu
OBJECTIVE: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. METHODS: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. RESULTS: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0...
November 2, 2018: Hypertension in Pregnancy
Lauren J Heath, Hailey Hyde, Christin Miller, Jill M Norris
OBJECTIVE: The purpose of this study is to determine the association between high elevation and hypertensive disorders of pregnancy (HDP). METHODS: Retrospective cohort study using Colorado birth certificate data to compare HDP at high (≥8,000 ft), moderate (4,501-7,999 ft), or low (≤4,500 ft) elevation using logistic regression. RESULTS: Among the cohort (n = 314,431), 3.4% of women developed a HDP. High or moderate elevation was not significantly associated with HDP relative to low elevation (adjusted odds ratio [aOR] 1...
November 1, 2018: Hypertension in Pregnancy
Vasilios Pergialiotis, Nikoleta Karampetsou, Panagiotis Zoumpourlis, Nikolaos Papantoniou, Nikolaos Thomakos, Georgios Daskalakis
OBJECTIVE: Neopterin is a pteridine that is produced following activation of human macrophages upon stimulation with the cytokine interferon-gamma. Several studies suggest its association with preeclampsia and the purpose of the present study is to evaluate this assumption. METHODS: We searched the Medline (1992-2018), Scopus (1993-2018) and Google Scholar (1993-2018) databases. All articles that evaluated serum neopterin levels in patients with preeclampsia were held eligible for inclusion, regardless of the trimester of pregnancy in which the measurement was performed...
October 9, 2018: Hypertension in Pregnancy
Ilkbal Temel Yuksel, Begum Aydogan Mathyk, Berna Aslan Cetin, Ugur Turhan, Zihniye Gonca Okumus, Gonca Yetkin Yildirim, Deniz Kanber Acar
OBJECTIVE: Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). METHODS: This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits...
October 6, 2018: Hypertension in Pregnancy
Kristina Kumer, Tanja Premru-Sršen, Vesna Fabjan-Vodušek, Nataša Tul, Teja Fabjan, Joško Osredkar
OBJECTIVE: To evaluate changes in vascular function and serum biomarkers in women with and without preeclampsia (PE) to create a model for the easier and more precise diagnosis of PE in the future. METHODS: Endothelial function and arterial stiffness were evaluated using peripheral arterial tonometry and concentrations of placental growth factor (PlGF), soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) were determined by immunoassay. RESULTS: Arterial stiffness deteriorates and endothelial function is better in women with PE compared with a healthy pregnancy...
October 4, 2018: Hypertension in Pregnancy
Muhammad Ilham Aldika Akbar, Mita Herdiyantini, Rozi Aditya Aryananda, Nareswari CIninta, Manggala Pasca Wardhana, Khanisyah Erza Gumilar, Budi Wicaksono, Ernawati, Agus Sulistyono, Aditiawarman, Hermanto Tri Joewono, Nadir Abdullah, Gustaaf Dekker, Erry Gumilar Dachlan, Muhammad Dikman Angsar
OBJECTIVE: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). METHODS: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks)...
October 2, 2018: Hypertension in Pregnancy
Anita S Malhotra, Poonam Goel, Archana Chaudhary, Suman Kochhar, Gurjit Kaur, Anumeha Bhagat
OBJECTIVE: Assessment of endothelial dysfunction for prediction of gestational hypertension/preeclampsia (GH/PE). METHODS: Serial assessment of flow-mediated vasodilatation (FMD) of brachial artery was done in first, second, and third trimesters, and within 6 weeks of delivery in primigravida (n = 654). Logistic regression was used to assess the predictive value of FMD for the development of GH/PE. RESULTS: Significant fall in FMD was observed from first trimester to third trimester but decrease in FMD in GH/PE group (57%) was more marked as compared to normal (39%) (p < 0...
October 1, 2018: Hypertension in Pregnancy
Nancy Anderson Niemczyk, Janet M Catov, Mansi M Desai, Candace K McClure, James M Roberts, Akira Sekikawa, Ping Guo Tepper, Emma Barinas-Mitchell
OBJECTIVE: To assess brachial artery distensibility and associated factors in healthy primigravidas. METHODS: We assessed brachial artery distensibility using the DynaPulse 5,000A in 37 women each trimester, and 6-8 weeks and 1-5 years postpartum. Associations with physical and cardiometabolic measures were considered. RESULTS: Mean (SE) brachial artery distensibility (%Δ/mmHg) decreased (stiffened) from 7.50 (0.20) 12-14 weeks to 6.93 (0...
September 26, 2018: Hypertension in Pregnancy
Emma von Wowern, Pia Saldeen, Per Olofsson
INTRODUCTION: Female sex hormones have vasorelaxing effects in non-pregnant and pregnant women. We aimed to investigate the effect of controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF), and early pregnancy, on arterial stiffness as assessed by digital pulse wave analysis (DPA), hypothesizing reduced arterial stiffness as an effect of increased estrogen levels. MATERIAL AND METHODS: A total of 68 women undergoing IVF were examined with DPA before conception and during IVF treatment with COH and embryo transfer (ET), and in gestational week seven in 19 women who became pregnant...
September 21, 2018: Hypertension in Pregnancy
Boya Li, Li Lin, Huixia Yang, Yuchun Zhu, Yumei Wei, Xiaotian Li, Dunjin Chen, Xianlan Zhao, Shihong Cui, Hongjuan Ding, Guifeng Ding, Haixia Meng, Hongwei Wei, Xiaotong Sun, Hong Xin
BACKGROUND: To identify the 24-h proteinuria value with quantitative analysis and how it correlates with the severity of preeclampsia and subsequent adverse maternal outcomes in the Chinese population. STUDY DESIGN: Eleven hospitals in 10 provinces across China were chosen, in which 1,738 pregnant women complicated by hypertensive disorders of pregnancy (HDP) with the records of 24 h proteinuria were enrolled. They were allocated into four groups: patients with maximal quantified proteinuria < 0...
August 2018: Hypertension in Pregnancy
Wen Wang, Dazhi Fan, Jun Wang, Shuzhen Wu, Ying Lu, Yunying He, Zhengping Liu
OBJECTIVE: Previous studies have reported a positive association between hypertensive disorders complicating pregnancy and placenta accreta. However, whether hypertensive disorders complicating pregnancy associated with placenta accreta is still not clear. The objective was to systematically review the literature to determine a possible association between hypertensive disorders complicating pregnancy and placenta accreta. METHODS: A systematic search of PubMed database, the Cochrane Library, Willy Online Library, and ScienceDirect database through 1st December 2015, was conducted...
August 2018: Hypertension in Pregnancy
Ahmed M Abbas, Engy M Fikry, Taha S Mostafa, Asmaa S Shaltout, Mona A H El-Baz
OBJECTIVE: To evaluate the levels of circulating sFlt-1 in pre-eclampsia (PE) and eclampsia patients and to assess its prognostic value in detection of PE complications. METHODS: The present study was a prospective cohort study conducted in tertiary hospital between January and December 2016. Included patients were divided into two groups; (Group I) severe PE group and (Group II) eclampsia group. Age-, parity-, and gestational age-matched women had approached to participate in the study as a control group (Group III)...
August 2018: Hypertension in Pregnancy
Farahnaz Keshavarzi, Shervin Mehdizadeh, Habibolah Khazaie, Mohammad Rasoul Ghadami
OBJECTIVE: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was defined by having a blood pressure (BP) > 140/90 mmHg on two occasions after the 20th week of pregnancy with excess protein in the urine (> 300 mg in 24 h) or 30 mg persistent proteinuria (+ 1 in dipsticks) in random samples...
August 2018: Hypertension in Pregnancy
Frederick Odun-Ayo, Jagidesa Moodley, Thajasvarie Naicker
OBJECTIVE: To determine the level and effect of urinary clusterin (CLU) and glutathione-s-transferase (GST) proteins in normotensive and preeclamptic pregnant women with HIV infection. METHODS: The urine concentration of CLU and GST in normotensive (n = 38) and preeclamptic pregnant (n = 38) women stratified by HIV status were estimated using the Bio-Plex® ProTM immunoassay. RESULTS: Across the group, a significant down-regulation of CLU (p = 0...
August 2018: Hypertension in Pregnancy
Velibor Čabarkapa, Mirjana Bogavac, Ana Jakovljević, Lato Pezo, Aleksandra Nikolić, Zoran Belopavlović, Djerić Mirjana
OBJECTIVES: The aim of this study was to evaluate the importance of serum concentration of magnesium (Mg) in the first trimester of pregnancy for predicting pre-eclampsia (PE). METHODS: This prospective study included 403 pregnant women over 18, with singleton pregnancy (from 11 to 14 weeks of pregnancy). The subjects were divided into a group who subsequently developed PE (PEKT) (n = 61), and a group of healthy pregnancies with no complications and with normal outcomes (TNT) (n = 342)...
August 2018: Hypertension in Pregnancy
Jose Ramon Duncan, Ana Marie Tobiasz, Zoran Bursac, Eric Vincent Rios-Doria, Mauro Humberto Schenone, Giancarlo Mari
OBJECTIVE: To compare the uterine artery pulsatility index (UtAPI-AP) before labor and immediate postpartum (UtAPI-PP) in hypertensive disorders of pregnancy (HTNP) and normotensives near term. METHODS: Pregnancies ≥36 weeks admitted for labor induction in our institution from October 2015 to October 2017 were included. We excluded active labor, multiple gestations, fetal demise, and those with inadequate uterine artery sampling. Our primary outcome was to compare the UtAPI-AP and UtAPI-PP between subjects with HTNP (gestational hypertension, preeclampsia with and without severe features) and normotensive participants...
August 2018: Hypertension in Pregnancy
Caroline C Marrs, Mahbubur Rahman, Luke Dixon, Gayle Olson
Our objective was to determine if elevated uric acid (UA) is associated with postpartum hypertension (PP HTN) in women without chronic hypertension. This is a secondary analysis of a randomized trial. We compared those with elevated UA to those with normal UA. Logistic regression was conducted to determine the association of elevated UA with PP HTN. Five hundred and fifty-six women met criteria. An UA level ≥ 5.2 mg/dL was associated with immediate PP HTN (adjusted odds ratio 2.44, 95% CI 1.63-3.64). The association was stronger among overweight and obese women...
August 2018: Hypertension in Pregnancy
Mohamed Rezk, Wael Gaber, Abdelhamid Shaheen, Ahmed Nofal, Mahmoud Emara, Awni Gamal, Hassan Badr
OBJECTIVE: To determine if second trimester mean platelet volume (MPV) and serum uric acid are reasonable predictors of preeclampsia (PE) or not, in patients at moderate and low risk. METHODS: This prospective study was conducted on 9522 women at low or moderate risk for developing PE who underwent dual measurements of MPV and serum uric acid at late first trimester (10-12 weeks) and at second trimester (18-20 weeks) and subsequently divided into two groups; PE group (n = 286) who later developed PE and non-PE group (n = 9236)...
August 2018: Hypertension in Pregnancy
Yonghong Lan, Zhi Yang, Mingmei Huang, Zhigang Cui, Yaling Qi, Haiyan Niu
OBJECTIVE: Preeclampsia is a common complication of pregnancy that is characterized by high blood pressure. Preeclampsia can have both negative maternal and fetal effects, including impaired fetal development from reduced placental perfusion. Because umbilical vessels provide fetal blood supply, morphological changes in these vessels can critically affect fetal function. This study investigated morphological and structural changes in umbilical veins from 17 controls and 19 preeclampsia cases...
August 2018: Hypertension in Pregnancy
Gbemisola E Osanyin, Kehinde S Okunade, Ayodeji Ayotunde Oluwole
BACKGROUND: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. AIM: This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia...
May 2018: Hypertension in Pregnancy
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