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Hypertension in Pregnancy

Emily W Harville, Markus Juonala, Jorma S A Viikari, Mika Kähönen, Olli T Raitakari
: Supplemental data for this article can be accessed at Objectives: To examine the relationship between pre-pregnancy indicators of cardiovascular risk and pregnancy complications and outcomes. STUDY DESIGN: Data from 359 female participants in the Cardiovascular Risk in Young Finns Study were linked with the national birth registry. Flow-mediated dilatation (FMD; maximum change in the left brachial artery diameter after rest and hyperemia); carotid intima-media thickness (IMT); Young's elastic modulus (YEM); and carotid artery distensibility (Cdist) at the visit prior to the pregnancy were examined as predictors of hypertensive disorders, birthweight, and gestational age using multivariable linear regression with adjustment for confounders (age, BMI, smoking, and socioeconomic status)...
November 18, 2016: Hypertension in Pregnancy
Alíssia Cardoso da Silva, Sérgio Hofmeister Martins-Costa, Edimárlei Gonsales Valério, José Geraldo Lopes Ramos
OBJECTIVE: To correlate serum selenium levels with hypertensive disorders of pregnancy (HDP) in a selected population and evaluate this mineral as a possible protective factor. METHODS: This case-control study included 32 normotensive, 20 hypertensive (chronic and gestational hypertension), and 38 preeclamptic pregnant women. All patients were recruited from antenatal or obstetric admissions of a tertiary hospital in Brazil. Serum selenium was measured at the time of inclusion...
November 11, 2016: Hypertension in Pregnancy
P Veena, Lakshmideepthi Perivela, S Soundara Raghavan
BACKGROUND: Hypertension in the postpartum period is a common phenomenon and is often a cause for concern. Following delivery, fluid that has been sequestered in the extravascular space is mobilized, producing a large auto-infusion of fluid from the extravascular to the intravascular compartment. As a result of this fluid mobilization process, there is an increase in central venous pressure and pulmonary capillary wedge pressure, which might favor the development of pulmonary edema. Thus, diuretics logically might be a better choice as antihypertensive medication in such a scenario...
November 11, 2016: Hypertension in Pregnancy
Orsolya Biró, Bálint Nagy, János Rigó
BACKGROUND: Preeclampsia (PE) is the major cause of maternal and fetal morbidity and mortality, affecting 3-8% of all pregnancies around the globe. miRNAs are small, noncoding RNA molecules, which negatively regulate gene expression. Abnormally expressed miRNAs contribute to pregnancy complications such as PE. The aim of our study was to find possible regulatory mechanisms by system biology approaches, which are connected to the pathogenesis of PE. METHODS: We integrated publicly available miRNA and gene expression profiles and created a network from the significant miRNA-mRNA pairs with the help of MAGIA and Cytoscape softwares...
November 11, 2016: Hypertension in Pregnancy
Ron Maymon, Alla Trahtenherts, Ran Svirsky, Yaakov Melcer, Liora Madar-Shapiro, Esther Klog, Hamutal Meiri, Howard Cuckle
OBJECTIVES: Construct a new preeclampsia predicting algorithm in twins. METHODS: Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk factors. RESULTS: The cohort included 9 PE (18 samples) and 96 unaffected cases (175 samples) twin pregnant women. The algorithm constructed of PlGF, PAPP-A, PP13, Doppler UTPI, and MAP with prior risk factors generated an area under the curve of 0...
November 11, 2016: Hypertension in Pregnancy
Zhan Zhang, Hui Liu, Ying Shi, Na Xu, Yuanyuan Wang, Aiping Li, Wanyu Song
OBJECTIVE: We aimed to investigate Th22 cells and their association with Th17 and Treg cells in the etiology of severe preeclampsia (sPE). METHODS: Thirty sPE patients and 30 healthy pregnant women were recruited in this study. The percentages of Th17, Th22, and regulatory T cells (Tregs) in the peripheral blood were measured by flow cytometry. ELISA was used to measure the plasma concentrations of interleukin (IL)-17, IL-22, and IL-10. RESULTS: The percentages of Th17 and Th22 cells and the plasma concentrations of IL-17 and IL-22 were significantly increased in sPE patients along with a decreased percentage of Treg cells and a decreased plasma IL-10 concentration...
November 11, 2016: Hypertension in Pregnancy
Rudolf Lampé, Ágnes Kövér, Sándor Szűcs, László Pál, Ervin Árnyas, Robert Póka
OBJECTIVE: Phagocyte function of neutrophil granulocytes and monocytes is decreased in healthy pregnancy and further decreased in preeclampsia. The cause of the declined function is unknown. Decreased phagocyte function can lead to the higher infection rate in healthy pregnancy and may also be responsible for the increased susceptibility to infections and high trophoblast concentration in preeclampsia. The aim of this study is to examine the phagocyte function of neutrophil granulocytes and monocytes...
November 11, 2016: Hypertension in Pregnancy
Lu Shi, Kara E MacLeod, Donglan Zhang, Fan Wang, Margaret Shin Chao
OBJECTIVE: To assess whether poor geographic accessibility to prenatal care, as indicated by long distance trips to prenatal care, produced high blood pressure (HPB) during pregnancy. METHODS: Using the 2007 Los Angeles Mommy and Baby Study for women without hypertension prior to pregnancy (n = 3405), we compared self-reported HBP by travel distance to prenatal care controlling for age, race/ethnicity, marital status, education, household income, weight status, and physical activity...
November 11, 2016: Hypertension in Pregnancy
Zehra Vural Yılmaz, Elif Akkaş, Gülenay Gençosmanoğlu Türkmen, Özgür Kara, Aykan Yücel, Dilek Uygur
OBJECTIVES: In this study, we hypothesized that dietary salt and potassium intake may be related with blood pressure, kidney damage and perinatal outcome in pregnants with preeclampsia (PE). METHODS: In total, 200 women (50 control women with healthy pregnancy, 150 women with PE) were recruited for the study. Daily salt and potassium intake was estimated based on calculation of 24-hour urinary sodium U[Na+] and potassium U[K+] excretion. U[Na+]/[K+] was calculated by dividing U[Na+] by U[K+]...
November 11, 2016: Hypertension in Pregnancy
Jennifer Banayan, Sarosh Rana, Ariel Mueller, Avery Tung, Hadi Ramadan, Zoltan Arany, Junaid Nizamuddin, Victor Novack, Barbara Scavone, Samuel M Brown, Sajid Shahul
OBJECTIVE: Cardiogenic shock (CS) may occur during pregnancy and dramatically worsen peripartum outcomes. METHODS: We analyzed the National Inpatient Sample from 2002 to 2013 to describe the incidence of, risk factors for and outcomes of CS during pregnancy. RESULTS: Of the 53,794,192 hospitalizations analyzed, 2044 were complicated by CS. The mortality rate in peripartum women with CS was 18.81% versus 0.02% without. It occurs more often during postpartum (58...
November 11, 2016: Hypertension in Pregnancy
Ping Tang, Jing Xu, Bao-Jun Xie, Qi-Mei Wang
OBJECTIVE: Preeclampsia (PE) is a disorder of pregnancy marked by hypertension and proteinuria with no known treatment aside from pregnancy termination. The pathogenesis of PE is poorly understood, but is thought to originate in the placenta. We assessed the value of measuring serum and urinary soluble deformylase-like tyrosine kinase receptor 1 (sFlt-1), a known target of placental factors, and placental growth factor (PLGF), a key placental signaling molecule, in the diagnosis of PE...
November 11, 2016: Hypertension in Pregnancy
Hao Zhu, Weimin Zhu, Rong Hu, Huijun Wang, Duan Ma, Xiaotian Li
OBJECTIVE: We aimed to study the impacts of pre-eclampsia on the cognitive and learning capabilities of adolescent rat offspring and to explore the possible underlying mechanisms at the molecular level. METHODS: Pregnant rats were subcutaneously injected with saline solution (control) (n = 16) or NG-nitro-L-arginine methyl ester (L-NAME) (n = 16) from the 13th day of gestation until parturition. The brain tissues from fetal rats delivered by cesarean section were examined in both groups with hematoxylin and eosin (H&E) staining...
October 27, 2016: Hypertension in Pregnancy
Kathryn J Sharma, Naomi Greene, Sarah J Kilpatrick
OBJECTIVE: To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension. STUDY DESIGN: This randomized controlled trial conducted between June 2014 and June 2015 included women who delivered at ≥32 weeks' gestation with persistent postpartum hypertension (sustained blood pressure ≥150/100 mmHg) requiring an oral antihypertensive agent...
October 27, 2016: Hypertension in Pregnancy
Indira Kosovic, Ivana Kuzmic Prusac, Anna Berkovic, Jelena Marusic, Marko Mimica, Sandra Zekic Tomas
OBJECTIVE: To investigate proliferation, EGF and EGFR expression of villous trophoblast (VTB), decidual cells (DC), and extravillous trophoblast (EVTB) in the placentas from pregnancies complicated with preeclampsia (PE) and to compare them with placentas from normal pregnancies. METHODS: Twenty-nine PE placentas and 19 control placentas were studied for EGF and EGFR immunohistochemical expression (noted as week, moderate or strong). Proliferation was expressed as the proliferation index...
September 22, 2016: Hypertension in Pregnancy
Cassandra N Spracklen, Caitlin J Smith, Audrey F Saftlas, Elizabeth W Triche, Andrew Bjonnes, Brendan J Keating, Richa Saxena, Patrick J Breheny, Andrew T Dewan, Jennifer G Robinson, Josephine Hoh, Kelli K Ryckman
OBJECTIVE: To examine the association between genetic predisposition to elevated C-reactive protein (CRP)and risk for preeclampsia using validated genetic loci for C-reactive protein. METHODS: Preeclampsia cases (n = 177) and normotensive controls (n = 116) were selected from live birth certificates to nulliparous Iowa women during the period August 2002-May 2005. Disease status was verified by the medical chart review. Genetic predisposition to CRP was estimated by a genetic risk score on the basis of established loci for CRP levels...
September 22, 2016: Hypertension in Pregnancy
Mohsen Vigeh, Emiko Nishioka, Kazuhito Yokoyama, Katsumi Ohtani, Takehisa Matsukawa
OBJECTIVE: Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined. METHODS: To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined. RESULTS: Early pregnancy blood Mn was significantly (p < 0.05) correlated with blood pressure through gestation...
September 20, 2016: Hypertension in Pregnancy
Xiaohua Zhao, Jingjing Liu, Cuisheng Zhao, Ping Ye, Jing Ji, Jingli Wang, Weiqing Song, Jine Xu, Shiguo Liu
OBJECTIVE: Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women. METHOD: A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR ...
September 19, 2016: Hypertension in Pregnancy
Jelena Milosevic-Stevanovic, Miljan Krstic, Dragana Radovic-Janosevic, Milan Stefanovic, Vladimir Antic, Ivana Djordjevic
OBJECTIVE: The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS: A prospective case-control study included a study group consisting of 30 pregnant women with preeclampsia completed by cesarean section (CS), in 19 of whom preeclampsia was associated with IUGR, and in 11 it was not. The control group consisted of 20 healthy pregnant women delivered by elective CS...
September 13, 2016: Hypertension in Pregnancy
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No abstract text is available yet for this article.
November 2016: Hypertension in Pregnancy
Sebastian Kwiatkowski, Ewa Kwiatkowska, Rafał Rzepka, Barbara Dołegowska, Andrzej Torbe, Agata Bartosik-Sławińska
OBJECTIVE: The shared pathogenesis of placental ischemia entitles us to create a single treatment model. We attempted to develop a unified method for monitoring ischemic placental syndrome patients using Doppler ultrasound of the uterine and umbilical arteries and disordered angiogenesis markers sFlt-1 and PlGF. MATERIAL AND METHODS: 182 pregnant women suffering from the ischemic placental syndrome were divided into four groups depending on the severity of their lesions revealed in the Doppler ultrasound examination and weeks of pregnancy...
November 2016: Hypertension in Pregnancy
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