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Hypertension in Pregnancy

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https://www.readbyqxmd.com/read/29308696/early-pregnancy-protein-multiplex-screening-reflects-circulating-and-urinary-divergences-associated-with-the-development-of-preeclampsia
#1
Margarita L Martinez-Fierro, Claudia Castruita-De La Rosa, Idalia Garza-Veloz, Rosa M Cardiel-Hernandez, Marcela A Espinoza-Juarez, Ivan Delgado-Enciso, Maria E Castañeda-Lopez, Edith Cardenas-Vargas, Fabiola Trejo-Vázquez, Elma I Sotelo-Ham, Rodrigo Castañeda-Miranda, Miguel A Cid-Baez, Jose M Ortiz-Rodriguez, Luis O Solis-Sanchez, Angelica Garcia Aviles, Yolanda Ortiz-Castro
BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. OBJECTIVE: To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. METHODS: We performed a nested cohort case-control study of pregnant women...
January 8, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29291357/associations-of-hypertensive-disorders-of-pregnancy-and-outcomes-of-labor-induction-with-prostaglandin-vaginal-inserts
#2
Lili Sheibani, Kyle Raymond, Olof Rugarn, Deborah A Wing
OBJECTIVE: To evaluate the association between hypertensive (HTNsive) disorders of pregnancy and outcomes of labor induction, in two cohorts of women induced with either misoprostol vaginal insert (MVI) or dinoprostone vaginal insert (DVI). STUDY DESIGN: This investigation was a post-hoc analysis of data from three Phase II and III, multi-center, double blind, randomized controlled trials of women induced with identical efficacy endpoints. A competing risk framework investigated the association between HTNsive disorders of pregnancy and the time-to-event endpoints of onset of active labor and vaginal delivery...
January 1, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29172779/the-effect-of-magnesium-sulfate-on-gene-expression-in-maternal-microvascular-endothelial-cells
#3
Dennis K Lee, Anindita Sengupta, Ori Nevo
Preeclampsia is a severe complication of pregnancy associated with maternal and fetal morbidity and mortality. To date, magnesium sulfate remains the preferred method of treatment used to reduce the development of eclampsia. Our aim was to investigate the effects of magnesium sulfate on the expression of genes involved with endothelial function in maternal microvascular endothelial cells from both normal and preeclamptic pregnancies. Primary cells from normal pregnancies treated with 80 mg/L magnesium sulfate for 6 h revealed an overall trend of increased expression of angiogenic and vasopressor-related factors by qPCR analyses...
November 27, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29157041/relation-with-postpartum-maternal-morbidity-of-different-types-of-anesthesia-in-preeclamptic-patients
#4
Hasan Ulubaşoğlu, Kadir Bakay, Davut Güven
OBJECTIVE: The aim of this study is to investigate the effect of different anesthesia types administered to patients with preeclampsia on postoperative maternal morbidities. METHODS: Medical records of pregnant women complicated with preeclampsia delivered by cesarean from January 2010 to December 2016 in our clinic were retrospectively reviewed. RESULTS: There was not a statistically significant difference between patients receiving spinal anesthesia and general anesthesia in terms of additional parenteral analgesic requirement at postoperative period (p = 0...
November 20, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29157033/alteration-in-methylation-level-at-differential-methylated-regions-of-mest-and-dlk1-in-fetus-of-preeclampsia
#5
Xiaoqing Wang, Liuxia Wan, Xiaoling Weng, Jiamin Xie, Aiping Zhang, Yun Liu, Minyue Dong
OBJECTIVES: Offspring born to preeclamptic women are at high risk for metabolic diseases in later life, but the mechanisms are not known. The purposes of the current investigation were to clarify the changes in DNA methylation at MEST and DLK1 DMRs in fetus of preeclampsia and to explore the possible mechanisms behind the high risk of adult diseases in the offspring of preeclampsia. METHODS: Fetal lymphocytes were isolated from umbilical cord blood of 78 women with preeclampsia and 95 women with normal pregnancy...
November 20, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29140734/preeclampsia-knowledge-among-women-in-utah
#6
Jessica Wilkinson, Gene Cole
BACKGROUND: Despite the benefits of preeclampsia (PE) education in improving health outcomes, little is known about how often healthcare providers in Utah include PE in prenatal education or how much information women retain. As such, the purpose of this study was to explore PE awareness among mothers in Utah and inquire how often PE is included in prenatal education. Factors associated with PE knowledge were also investigated. METHODS: A cross-sectional survey was conducted...
November 15, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29135310/adamts-1-4-12-and-13-levels-in-maternal-blood-cord-blood-and-placenta-in-preeclampsia
#7
Müberra Namlı Kalem, Ziya Kalem, Tuncay Yüce, Feride Soylemez
The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. Based on the immunohistochemistry (IHC) results, ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group...
November 14, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29131741/editorial-board-page-eov
#8
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29125378/type-of-obstetric-anesthesia-administered-and-complications-in-women-with-preeclampsia-in-low-and-middle-income-countries-a-systematic-review
#9
Soha Sobhy, Kuhan Dharmarajah, David Arroyo-Manzano, Ramesan Navanatnarajah, James Noblet, Javier Zamora, Shakila Thangaratinam
BACKGROUND: Delivery is often expedited with cesarean section, necessitating anesthesia, to prevent complications in women with preeclampsia. Anesthesia-associated risks in these women from low- and middle-income countries (LMICs) are not known. METHODS: We searched major databases (until February 2017) for studies on general vs. regional anesthesia in women with preeclampsia. We summarized the association between outcomes and type of anesthesia using a random effects model and reported as odds ratio (OR) with 95% confidence intervals (95% CIs)...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29115889/circulating-fetal-and-total-cell-free-dna-and-shla-g-in-black-south-african-women-with-gestational-hypertension-and-pre-eclampsia
#10
Simeon Eche, Irene Mackraj, Jagidesa Moodley
OBJECTIVE: Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia. METHODS: Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive patients using real-time qPCR. Soluble HLAG was measured by enzyme-linked immune-sorbent assay. RESULTS: Serum fetal and total cfDNA levels were higher in pre-eclampsia compared with the controls and gestational hypertensives (p < 0...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29058512/maternal-serum-autotaxin-levels-in-early-and-late-onset-preeclampsia
#11
Hakan Erenel, Nevin Yilmaz, Tayfur Cift, Berk Bulut, Isik Sozen, Berna Aslan Cetin, Altay Gezer, Hakan Ekmekci, Baris Kaya, Abdullah Tuten
PURPOSE: We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. METHODS: A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia (n = 31) and late-onset preeclampsia (n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29058492/association-between-the-soluble-epoxide-hydrolase-gene-and-preeclampsia
#12
Ismail Sari, Hatice Pinarbasi, Ergun Pinarbasi, Caglar Yildiz
OBJECTIVE: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women. METHODS: K55R polymorphism and methylation level of the EPHX2 promoter were determined by the real-time PCR using double-dye hydrolysis probes and methylation-sensitive high-resolution melting analysis, respectively. RESULTS: The presence of the K55R polymorphism was significantly higher in cases (28...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29039998/fn1-fos-and-itga5-induce-preeclampsia-abnormal-expression-and-methylation
#13
Mei Zhao, Lin Li, Xiumei Yang, Jianying Cui, Hong Li
OBJECTIVE: As a frequent hypertensive disorder in pregnancy, preeclampsia causes 15% of all preterm deliveries. This study aims to understand its mechanism via analyzing gene expression and methylation data. METHODS: Human gene expression microarray data (GSE73374) and corresponding DNA methylation microarray data (GSE73375) of preeclamptic placental tissues (n = 19) and normotensive placental tissues (n = 17) were obtained from the Gene Expression Omnibus. Differentially expressed genes (DEGs), differentially methylated regions (DMRs) and CpG islands (DMIs) were identified and compared...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29039975/maternal-and-cord-blood-cyclophilin-a-in-severe-preeclampsia-and-normal-pregnancy-and-its-correlation-with-vitamin-d-and-zinc
#14
Noroyono Wibowo, Riyan Hari Kurniawan, Rima Irwinda, Natasya Prameswari
OBJECTIVE: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level. METHODS: We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014. RESULTS: Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29039974/role-of-kidney-biomarkers-kidney-injury-molecule-1-calbindin-interleukin-18-and-monocyte-chemoattractant-protein-1-in-hiv-associated-pre-eclampsia
#15
Soumaya Abdullatif Eltounali, Jagidesa Moodley, Thajasvarie Naicker
OBJECTIVE: Both HIV infection and pre-eclampsia (PE) are associated with considerable maternal mortality in South Africa. This study was designed to compare the urinary levels of kidney injury molecule-1 (KIM-1), calbindin, interleukin-18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1) in HIV associated normotensive and preeclamptic pregnancies. METHODS: Following ethical approval and written consent, urine samples were collected from HIV negative (HIV -ve) normotensive pregnant (n = 19), HIV positive (HIV +ve) normotensive pregnant (n = 19), HIV -ve pre-eclamptic (n = 19) and HIV +ve pre-eclamptic (n = 19) women...
November 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28841341/systemic-vascular-resistance-and-endogenous-inhibitors-of-nitric-oxide-synthesis-in-early-compared-to-late-onset-preeclampsia-preliminary-findings
#16
Miha Lucovnik, Helmut Karl Lackner, Ilona Papousek, Karin Schmid-Zalaudek, Guenter Schulter, Andreas Roessler, Manfred Georg Moertl
OBJECTIVE: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. METHODS: Twenty-four preeclamptic patients (14 at ≥ 34 weeks') and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. ADMA and SDMA levels were determined using enzyme-linked immunosorbent assay. RESULTS: SVRI and SDMA were higher in preeclampsia overall, in early onset and late onset compared to controls...
August 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28678644/the-pathology-of-eclampsia-an-autopsy-series
#17
Jonathan L Hecht, Jaume Ordi, Carla Carrilho, Mamudo R Ismail, Zsuzsanna K Zsengeller, S Ananth Karumanchi, Seymour Rosen
OBJECTIVE: We describe the main lesions in the liver, brain, and kidney from autopsies of women who died of eclampsia and characterize the endothelial injury. METHODS: Cases were identified from a study involving 317 maternal deaths (2003-2006) conducted at the Maputo Central Hospital (Maputo, Mozambique) in association with ISGlobal (Barcelona, Spain). Histology slides along with stains for endothelial, histiocyte, and platelet markers (CD31, CD34, CD68, CD42B) were reviewed to identify the relevant lesions...
August 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28635350/corrigendum
#18
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28627965/role-of-angiopoietin-2-endoglin-and-placental-growth-factor-in-hiv-associated-preeclampsia
#19
Nokuzola Mbhele, Jagidesa Moodley, Thajasvarie Naicker
OBJECTIVE: The factors angiopoeitin-2 (Ang-2), endoglin (Eng), and placental growth factor (PlGF) have been implicated in the pathophysiology of preeclampsia (PE). This study assessed their serum levels in HIV-negative and HIV-positive pregnant normotensive and pre-eclamptic women. METHODS: Participants were recruited at the antenatal clinic, serum samples were evaluated using the Bioplex Human Cancer Biomarker (panel 2). RESULTS: Ang-2 and Eng levels were higher, whilst PlGF levels were lower in the PE compared with the normotensive group...
August 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28609144/therapeutic-benefit-of-mesenchymal-stem-cells-in-pregnant-rats-with-angiotensin-receptor-agonistic-autoantibody-induced-hypertension-implications-for-immunomodulation-and-cytoprotection
#20
Dan Zhang, Lihua Fu, Leilei Wang, Lin Lin, Lihong Yu, Lijun Zhang, Tao Shang
Immunomodulation by mesenchymal stem cells (MSCs) is potentially important for maintaining peripheral tolerance. Preeclampsia may be due to maternal immune rejection of the genetically foreign fetus. This study aimed to investigate the biological function of human umbilical cord-derived mesenchymal stem cells (HU-MSCs) for the treatment of angiotensin receptor agonistic autoantibody (AT1-AA)-induced hypertension during pregnancy. HU-MSCs were isolated, cultured, and labeled in vitro. AT1-AA and HU-MSCs were administered to pregnant rats...
August 2017: Hypertension in Pregnancy
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