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Hypertension in Pregnancy

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https://www.readbyqxmd.com/read/30238809/arterial-stiffness-during-controlled-ovarian-hyperstimulation-and-early-pregnancy-in-women-exposed-to-assisted-reproduction
#1
Emma von Wowern, Pia Saldeen, Per Olofsson
INTRODUCTION: Female sex hormones have vasorelaxing effects in non-pregnant and pregnant women. We aimed to investigate the effect of controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF), and early pregnancy, on arterial stiffness as assessed by digital pulse wave analysis (DPA), hypothesizing reduced arterial stiffness as an effect of increased estrogen levels. MATERIAL AND METHODS: A total of 68 women undergoing IVF were examined with DPA before conception and during IVF treatment with COH and embryo transfer (ET), and in gestational week seven in 19 women who became pregnant...
September 21, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30040505/the-value-of-the-24-h-proteinuria-in-evaluating-the-severity-of-preeclampsia-and-predicting-its-adverse-maternal-outcomes
#2
Boya Li, Li Lin, Huixia Yang, Yuchun Zhu, Yumei Wei, Xiaotian Li, Dunjin Chen, Xianlan Zhao, Shihong Cui, Hongjuan Ding, Guifeng Ding, Haixia Meng, Hongwei Wei, Xiaotong Sun, Hong Xin
BACKGROUND: To identify the 24-h proteinuria value with quantitative analysis and how it correlates with the severity of preeclampsia and subsequent adverse maternal outcomes in the Chinese population. STUDY DESIGN: Eleven hospitals in 10 provinces across China were chosen, in which 1,738 pregnant women complicated by hypertensive disorders of pregnancy (HDP) with the records of 24 h proteinuria were enrolled. They were allocated into four groups: patients with maximal quantified proteinuria < 0...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30040502/association-between-hypertensive-disorders-complicating-pregnancy-and-risk-of-placenta-accreta-a-meta-analysis-and-systematic-review
#3
Wen Wang, Dazhi Fan, Jun Wang, Shuzhen Wu, Ying Lu, Yunying He, Zhengping Liu
OBJECTIVE: Previous studies have reported a positive association between hypertensive disorders complicating pregnancy and placenta accreta. However, whether hypertensive disorders complicating pregnancy associated with placenta accreta is still not clear. The objective was to systematically review the literature to determine a possible association between hypertensive disorders complicating pregnancy and placenta accreta. METHODS: A systematic search of PubMed database, the Cochrane Library, Willy Online Library, and ScienceDirect database through 1st December 2015, was conducted...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30032672/prognostic-value-of-serum-soluble-fms-like-tyrosine-kinase-sflt-1-levels-in-pre-eclampsia-and-eclampsia-a-prospective-cohort-study
#4
Ahmed M Abbas, Engy M Fikry, Taha S Mostafa, Asmaa S Shaltout, Mona A H El-Baz
OBJECTIVE: To evaluate the levels of circulating sFlt-1 in pre-eclampsia (PE) and eclampsia patients and to assess its prognostic value in detection of PE complications. METHODS: The present study was a prospective cohort study conducted in tertiary hospital between January and December 2016. Included patients were divided into two groups; (Group I) severe PE group and (Group II) eclampsia group. Age-, parity-, and gestational age-matched women had approached to participate in the study as a control group (Group III)...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30024780/objective-assessment-of-obstructive-sleep-apnea-in-normal-pregnant-and-preeclamptic-women
#5
Farahnaz Keshavarzi, Shervin Mehdizadeh, Habibolah Khazaie, Mohammad Rasoul Ghadami
OBJECTIVE: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was defined by having a blood pressure (BP) > 140/90 mmHg on two occasions after the 20th week of pregnancy with excess protein in the urine (> 300 mg in 24 h) or 30 mg persistent proteinuria (+ 1 in dipsticks) in random samples...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30024772/urinary-clusterin-and-glutathione-s-transferase-levels-in-hiv-positive-normotensive-and-preeclamptic-pregnancies
#6
Frederick Odun-Ayo, Jagidesa Moodley, Thajasvarie Naicker
OBJECTIVE: To determine the level and effect of urinary clusterin (CLU) and glutathione-s-transferase (GST) proteins in normotensive and preeclamptic pregnant women with HIV infection. METHODS: The urine concentration of CLU and GST in normotensive (n = 38) and preeclamptic pregnant (n = 38) women stratified by HIV status were estimated using the Bio-Plex® ProTM immunoassay. RESULTS: Across the group, a significant down-regulation of CLU (p = 0...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30019975/serum-magnesium-level-in-the-first-trimester-of-pregnancy-as-a-predictor-of-pre-eclampsia-a-pilot-study
#7
Velibor Čabarkapa, Mirjana Bogavac, Ana Jakovljević, Lato Pezo, Aleksandra Nikolić, Zoran Belopavlović, Djerić Mirjana
OBJECTIVES: The aim of this study was to evaluate the importance of serum concentration of magnesium (Mg) in the first trimester of pregnancy for predicting pre-eclampsia (PE). METHODS: This prospective study included 403 pregnant women over 18, with singleton pregnancy (from 11 to 14 weeks of pregnancy). The subjects were divided into a group who subsequently developed PE (PEKT) (n = 61), and a group of healthy pregnancies with no complications and with normal outcomes (TNT) (n = 342)...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30019974/uterine-artery-flow-velocity-waveforms-before-and-after-delivery-in-hypertensive-disorders-of-pregnancy-near-term
#8
Jose Ramon Duncan, Ana Marie Tobiasz, Zoran Bursac, Eric Vincent Rios-Doria, Mauro Humberto Schenone, Giancarlo Mari
OBJECTIVE: To compare the uterine artery pulsatility index (UtAPI-AP) before labor and immediate postpartum (UtAPI-PP) in hypertensive disorders of pregnancy (HTNP) and normotensives near term. METHODS: Pregnancies ≥36 weeks admitted for labor induction in our institution from October 2015 to October 2017 were included. We excluded active labor, multiple gestations, fetal demise, and those with inadequate uterine artery sampling. Our primary outcome was to compare the UtAPI-AP and UtAPI-PP between subjects with HTNP (gestational hypertension, preeclampsia with and without severe features) and normotensive participants...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30014728/the-association-of-hyperuricemia-and-immediate-postpartum-hypertension-in-women-without-a-diagnosis-of-chronic-hypertension
#9
Caroline C Marrs, Mahbubur Rahman, Luke Dixon, Gayle Olson
Our objective was to determine if elevated uric acid (UA) is associated with postpartum hypertension (PP HTN) in women without chronic hypertension. This is a secondary analysis of a randomized trial. We compared those with elevated UA to those with normal UA. Logistic regression was conducted to determine the association of elevated UA with PP HTN. Five hundred and fifty-six women met criteria. An UA level ≥ 5.2 mg/dL was associated with immediate PP HTN (adjusted odds ratio 2.44, 95% CI 1.63-3.64). The association was stronger among overweight and obese women...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29893156/first-versus-second-trimester-mean-platelet-volume-and-uric-acid-for-prediction-of-preeclampsia-in-women-at-moderate-and-low-risk
#10
Mohamed Rezk, Wael Gaber, Abdelhamid Shaheen, Ahmed Nofal, Mahmoud Emara, Awni Gamal, Hassan Badr
OBJECTIVE: To determine if second trimester mean platelet volume (MPV) and serum uric acid are reasonable predictors of preeclampsia (PE) or not, in patients at moderate and low risk. METHODS: This prospective study was conducted on 9522 women at low or moderate risk for developing PE who underwent dual measurements of MPV and serum uric acid at late first trimester (10-12 weeks) and at second trimester (18-20 weeks) and subsequently divided into two groups; PE group (n = 286) who later developed PE and non-PE group (n = 9236)...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29733777/morphological-and-structural-changes-of-umbilical-veins-and-clinical-significance-in-preeclampsia
#11
Yonghong Lan, Zhi Yang, Mingmei Huang, Zhigang Cui, Yaling Qi, Haiyan Niu
OBJECTIVE: Preeclampsia is a common complication of pregnancy that is characterized by high blood pressure. Preeclampsia can have both negative maternal and fetal effects, including impaired fetal development from reduced placental perfusion. Because umbilical vessels provide fetal blood supply, morphological changes in these vessels can critically affect fetal function. This study investigated morphological and structural changes in umbilical veins from 17 controls and 19 preeclampsia cases...
August 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29718786/association-between-serum-ca125-levels-in-preeclampsia-and-its-severity-among-women-in-lagos-south-west-nigeria
#12
Gbemisola E Osanyin, Kehinde S Okunade, Ayodeji Ayotunde Oluwole
BACKGROUND: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. AIM: This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29714512/association-of-angiotensin-receptor-2-gene-polymorphisms-with-pregnancy-induced-hypertension-risk
#13
Chenyang Li, Weijun Peng, Heng Zhang, Weirong Yan
OBJECTIVES: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. METHODS: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29694251/cardiovascular-risk-after-preeclampsia-the-effect-of-communicating-risk-factors-on-intended-healthy-behavior
#14
Anouk Bokslag, Willemieke Kroeze, Christianne J M de Groot, Pim W Teunissen
OBJECTIVE: We studied the effect of communicating cardiovascular risk factors on intended healthy behavior in women with a history of preeclampsia or uncomplicated pregnancy. METHODS: Intention for healthy behavior was assessed before and after cardiovascular risk assessment. Changes were calculated for women with and without cardiovascular risk factors. RESULTS: In women with cardiovascular risk factors, the intention to quit smoking increased; whereas, intended healthy diet and sufficient exercise did not change...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29658370/changes-in-endothelial-function-arterial-stiffness-and-blood-pressure-in-pregnant-women-after-consumption-of-high-flavanol-and-high-theobromine-chocolate-a-double-blind-randomized-clinical-trial
#15
Asma Babar, Emmanuel Bujold, Vicky Leblanc, Élise Lavoie-Lebel, Joalee Paquette, Laurent Bazinet, Simone Lemieux, Isabelle Marc, Belkacem Abdous, Sylvie Dodin
OBJECTIVES: The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS: 131 pregnant women considered at risk of preeclampsia based on uterine artery Doppler ultrasound were divided into two groups (HFHT or low flavanol and theobromine chocolate (LFLT)...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29575956/relation-of-locus-1p13-rs646776-polymorphism-with-the-risk-of-preeclampsia
#16
Rana H Emam, Maivel H Ghattas, Noha M Mesbah, Dina M Abo-Elmatty, Eman T Mehanna
OBJECTIVE: This study aimed to assess the relation of locus 1p13 rs646776 (T/C) polymorphism with preeclampsia in Egyptian women. METHODS: The study included 100 healthy pregnant female subjects and 100 preeclampsia patients. The genotypes of the polymorphisms were assessed. Endothelin-1 level was determined in plasma. RESULTS: The major T allele of the 1p13.3 genomic region rs646776 polymorphism had a higher frequency in preeclampsia patients...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29495906/safety-of-a-physical-therapy-protocol-for-women-with-preeclampsia-a-randomized-controlled-feasibility-trial
#17
Tawana Vicente Bertagnolli, Michelle de Souza Rangel Machado, Cristine Jorge Homsi Ferreira, Jackeline de Souza Rangel Machado, Geraldo Duarte, Ricardo Carvalho Cavalli
OBJECTIVE: To assess the feasibility and safety of a physiotherapy protocol applied to pregnant women with preeclampsia. METHODS: Randomized, controlled, single-blind feasibility study, with 24 hospitalized pregnant women with preeclampsia. The intervention group received one session of the physiotherapy. The control group remained under the routine care of the hospital. The primary outcomes were Doppler velocimetry, cardiotocography, and maternal-fetal hemodynamics...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29308696/early-pregnancy-protein-multiplex-screening-reflects-circulating-and-urinary-divergences-associated-with-the-development-of-preeclampsia
#18
Margarita L Martinez-Fierro, Claudia Castruita-De La Rosa, Idalia Garza-Veloz, Rosa M Cardiel-Hernandez, Marcela A Espinoza-Juarez, Ivan Delgado-Enciso, Maria E Castañeda-Lopez, Edith Cardenas-Vargas, Fabiola Trejo-Vázquez, Elma I Sotelo-Ham, Rodrigo Castañeda-Miranda, Miguel A Cid-Baez, Jose M Ortiz-Rodriguez, Luis O Solis-Sanchez, Angelica Garcia Aviles, Yolanda Ortiz-Castro
BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. OBJECTIVE: To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. METHODS: We performed a nested cohort case-control study of pregnant women...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29291357/associations-of-hypertensive-disorders-of-pregnancy-and-outcomes-of-labor-induction-with-prostaglandin-vaginal-inserts
#19
Lili Sheibani, Kyle Raymond, Olof Rugarn, Deborah A Wing
OBJECTIVE: To evaluate the association between hypertensive (HTNsive) disorders of pregnancy and outcomes of labor induction, in two cohorts of women induced with either misoprostol vaginal insert (MVI) or dinoprostone vaginal insert (DVI). STUDY DESIGN: This investigation was a post-hoc analysis of data from three Phase II and III, multi-center, double blind, randomized controlled trials of women induced with identical efficacy endpoints. A competing risk framework investigated the association between HTNsive disorders of pregnancy and the time-to-event endpoints of onset of active labor and vaginal delivery...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29172779/the-effect-of-magnesium-sulfate-on-gene-expression-in-maternal-microvascular-endothelial-cells
#20
Dennis K Lee, Anindita Sengupta, Ori Nevo
Preeclampsia is a severe complication of pregnancy associated with maternal and fetal morbidity and mortality. To date, magnesium sulfate remains the preferred method of treatment used to reduce the development of eclampsia. Our aim was to investigate the effects of magnesium sulfate on the expression of genes involved with endothelial function in maternal microvascular endothelial cells from both normal and preeclamptic pregnancies. Primary cells from normal pregnancies treated with 80 mg/L magnesium sulfate for 6 h revealed an overall trend of increased expression of angiogenic and vasopressor-related factors by qPCR analyses...
February 2018: Hypertension in Pregnancy
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