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Experimental and Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/28301174/differential-characteristics-of-ketamine-self-administration-in-the-olfactory-bulbectomy-model-of-depression-in-male-rats
#1
Zuzana Babinska, Jana Ruda-Kucerova
Ketamine has been extensively studied for its antidepressant potential, with promising results in both preclinical and clinical studies. However, concerns regarding its abuse liabilities greatly limit its potential to become an approved treatment for depression. Therefore, a better understanding the risks and benefits of ketamine use in depression is needed. This study aimed to assess the characteristics of operant intravenous (IV) ketamine self-administration and relapse-like behavior in the olfactory bulbectomy (OBX) model of depression in male rats...
March 16, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28287794/a-systematic-review-of-the-free-pour-assessment-implications-for-research-assessment-and-intervention
#2
Nicole R Schultz, Carolynn S Kohn, Megan Schmerbauch, Christopher J Correia
Excessive alcohol consumption is a major concern. Alcohol consumption data are typically collected via self-report questionnaires. However, research has suggested that individuals are unable to identify a standard drink size and that their self-report may be influenced by certain environmental conditions, calling into question the reliability and validity of self-report. The free-pour is an objective measure that may provide a clearer picture of current alcohol consumption trends, individuals' knowledge of standard drink sizes, and accuracy of self-report...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28287793/topiramate-reduces-basal-anxiety-and-relieves-ethanol-withdrawal-induced-anxious-behaviors-in-male-rats
#3
Décio D Junqueira-Ayres, Laila Asth, Adriana S F S J Ayres, Bruno Lobão-Soares, Vanessa de Paula Soares-Rachetti, Elaine C Gavioli
Anxiety disorders are associated with increased impairments in psychosocial functioning, work productivity and health-related quality of life. In addition, anxiety is a common symptom of ethanol withdrawal and it strongly contributes to relapse. Benzodiazepines are frequently prescribed for relief of anxiety and ethanol withdrawal symptoms but considerable side effects, such sedation, tolerance and dependence, are observed during treatment. Therefore, better drugs are needed for the treatment of anxiety states...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28287792/chronic-corticosterone-administration-effects-on-behavioral-emotionality-in-female-c57bl6-mice
#4
Maryam Mekiri, Alain M Gardier, Denis J David, Jean-Philippe Guilloux
Understanding the pathophysiology of affective disorders and their treatment relies on the availability of experimental models that mimic aspects of the disease. Most of the studies on depressive disorders are conducted with male rodents, mostly because including females in protocols is more difficult. Indeed, there is a complex series of changes in the brain of females due to the estrous cycle, adding an important variability factor to the disease. However, twice as many women as men have a lifetime diagnosis of major depressive disorder (MDD), so we need to develop reliable female models of depression to improve our understanding of this disease...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28287791/adolescent-chronic-restraint-stress-acrs-elicits-robust-depressive-like-behavior-in-freely-cycling-adult-female-rats-without-increasing-anxiety-like-behaviors
#5
Meghan Hibicke, Martha A Graham, Renée L Hayslett
Stress during times of rapid development is a risk factor for Major Depressive Disorder, a mood disorder that disproportionately affects women. We developed an adolescent chronic restraint stress (aCRS) protocol using female rats to address the impact of adolescent stress on female adult depressive-like behavior. Animals were divided into 4 treatment groups: not restrained:saline (NRSAL), not restrained:desipramine (NRDES), restrained:saline (RSAL), and restrained:desipramine (RDES). NRSAL and NRDES rats were housed in a separate colony room from RSAL and RDES rats...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28287790/cocaine-self-administration-in-male-and-female-rats-perinatally-exposed-to-pcbs-evaluating-drug-use-in-an-animal-model-of-environmental-contaminant-exposure
#6
Mellessa M Miller, Abby E Meyer, Jenna L N Sprowles, Helen J K Sable
Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants known to adversely impact human health. Ortho-substituted PCBs affect the nervous system, including the brain dopaminergic system. The reinforcing effects of psychostimulants are typically modulated via the dopaminergic system, so this study used a preclinical (i.e., rodent) model to evaluate whether developmental contaminant exposure altered intravenous self-administration (IV SA) for the psychostimulant cocaine. Long-Evans rats were perinatally exposed to 6 or 3 mg/kg/day of PCBs throughout gestation and lactation and compared with nonexposed controls...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28287789/effects-of-adolescent-exposure-to-methylmercury-and-d-amphetamine-on-reversal-learning-and-an-extradimensional-shift-in-male-mice
#7
Steven R Boomhower, M Christopher Newland
Adolescence is associated with the continued maturation of dopamine neurotransmission and is implicated in the etiology of many psychiatric illnesses. Adolescent exposure to neurotoxicants that distort dopamine neurotransmission, such as methylmercury (MeHg), may modify the effects of chronic d-amphetamine (d-AMP) administration on reversal learning and attentional-set shifting. Male C57Bl/6n mice were randomly assigned to two MeHg-exposure groups (0 ppm and 3 ppm) and two d-AMP-exposure groups (saline and 1 mg/kg/day), producing four treatment groups (n = 10-12/group): control, MeHg, d-AMP, and MeHg + d-AMP...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28240925/protective-behavioral-strategies-as-a-context-specific-mediator-a-multilevel-examination-of-within-and-between-person-associations-of-daily-drinking
#8
Abby L Braitman, Ashley N Linden-Carmichael, James M Henson
Research indicates that a drinker's environmental and social context can be differentially associated with drinking outcomes. Further, although many researchers have identified that more frequent use of protective behavioral strategies (PBS) is associated with lower alcohol consumption and negative consequences, scant research has examined how one's drinking context may promote or hinder PBS use. The present study examined how the context of drinking each day (i.e., where and with whom) is associated with level of consumption and reported alcohol-related problems among n = 284 college drinkers (69...
February 27, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28240924/time-constraints-in-the-alcohol-purchase-task
#9
Brent A Kaplan, Derek D Reed, James G Murphy, Amy J Henley, Florence D DiGennaro Reed, Peter G Roma, Steven R Hursh
Hypothetical purchase tasks have advanced behavioral economic evaluations of demand by circumventing practical and ethical restrictions associated with delivering drug reinforcers to participants. Numerous studies examining the reliability and validity of purchase task methodology suggest that it is a valuable method for assessing demand that warrants continued use and evaluation. Within the literature examining purchase tasks, the alcohol purchase task (APT) has received the most investigation, and currently represents the most experimentally validated variant...
February 27, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28150972/a-novel-training-approach-to-activate-alternative-behaviors-for-smoking-in-depressed-smokers
#10
Catalina Kopetz, Laura MacPherson, Avery D Mitchell, Alexandra N Houston-Ludlam, Reinout W Wiers
The current research developed and tested a novel training strategy to alter the implicit associations between alternative behaviors to smoking and negative affect, and explored its effects on depressive symptoms and on smoking behavior as part of a quit attempt. Using a joystick, participants identified as smokers with depressive symptoms were trained to approach alternative behaviors to smoking in the context of negative affect. Specifically, in the experimental condition, participants were trained to avoid smoking-related targets and to approach alternative activities...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28150971/effects-of-bupropion-sustained-release-on-task-related-eeg-alpha-activity-in-smokers-individual-differences-in-drug-response
#11
Jian Zhu, Ryan P Coppens, Norka E Rabinovich, David G Gilbert
The mechanisms underlying bupropion's efficacy as an antidepressant and a smoking cessation aid are far from being fully characterized. The present study is the first to examine the effects of bupropion on visuospatial task-related parietal EEG alpha power asymmetry-an asymmetry that has previously been found to be associated with severity of depressive symptoms (i.e., the more depressive symptoms, the greater alpha power in the right vs. left parietal area [Henriques & Davidson, 1997; Rabe, Debener, Brocke, & Beauducel, 2005])...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28150970/neural-outcome-processing-of-peer-influenced-risk-taking-behavior-in-late-adolescence-preliminary-evidence-for-gene-%C3%A3-environment-interactions
#12
Troy A Webber, Heather E Soder, Geoffrey F Potts, Jong Y Park, Marina A Bornovalova
Adolescent brains are particularly susceptible to the rewarding properties of risky decisions in social contexts. Individual differences in genetic influences on dopamine transmission moderate neural outcome processing of risky decisions and may exert pronounced effects on adolescent risk-taking behavior (RTB) and corresponding neural outcome processing in peer contexts, a process called gene-environment interaction (G × E). Eighty-five undergraduate students completed a behavioral risk task alone and in the presence of a confederate peer providing "risky" feedback...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28150969/-do-grown-ups-become-happy-when-they-drink-alcohol-expectancies-among-preschoolers
#13
Emmanuel Kuntsche
Despite ample evidence on risky drinking in adolescence and beyond, little is known about early alcohol-related precursors. The present study investigates whether preschool children are already familiar with the emotional changes that are likely to occur when people drink alcohol, that is, their alcohol expectancies. Based on the circumplex model of affect (CMA; Russell, 1980), expectancies (12 items for alcohol and 12 for soft drinks) were assessed using the Berkeley Puppet Interview (BPI; Measelle, Ablow, Cowan, & Cowan, 1998) among 198 3- to 6-year-olds (52...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28150968/the-effects-of-contextual-familiarity-on-alcohol-expectancies
#14
Catharine E Fairbairn, Konrad Bresin
Social familiarity has been widely studied by researchers across a range of psychological disciplines, with level of familiarity in social context being indicated as a powerful factor influencing affective and motivational states. The degree of familiarity among drinking companions has further been linked to patterns of alcohol use, with regular drinking in unfamiliar social settings being associated with heavy consumption and drinking in highly familiar settings being indicated as a potentially protective factor...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27936816/altered-subjective-reward-valuation-among-female-heavy-marijuana-users
#15
Kathryn R Hefner, Mark J Starr
Maladaptive decision-making is a cardinal feature of drug use, contributing to ongoing use, and reflecting alterations in how drug users assess uncertain reward value. Accumulating evidence indicates the consequences of heavy marijuana use are worse for female versus male animals and humans, but research assessing sex differences in reward-related decision-making among marijuana users remains scarce. We examined sex differences in the subjective valuation of certain and uncertain rewards among heavy marijuana users (52; 26 male and 26 female) and controls (52; 26 male and 26 female)...
February 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27929349/effects-of-paclitaxel-on-mechanical-sensitivity-and-morphine-reward-in-male-and-female-c57bl6-mice
#16
Harshini Neelakantan, Sara Jane Ward, Ellen Ann Walker
This study evaluated the hypothesis that a paclitaxel treatment regimen sufficient to produce mechanical allodynia would alter sensitivities of male and female mice to the conditioned rewarding and reinforcing effects of morphine. Saline or paclitaxel were administered on Days 1, 3, 5, and 7 in male and female C57Bl/6 mice to induce morphine-reversible mechanical allodynia as measured by the Von Frey filament test. Paclitaxel treatment did not change sensitivity to morphine conditioned place preference (CPP) relative to saline treatment in either male or female mice...
December 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27929348/shallow-discounting-of-delayed-cocaine-by-male-rhesus-monkeys-when-immediate-food-is-the-choice-alternative
#17
Sally L Huskinson, Joel Myerson, Leonard Green, James K Rowlett, William L Woolverton, Kevin B Freeman
Huskinson et al. (2015) recently examined delay discounting in monkeys choosing between an immediate drug (cocaine) reinforcer and a delayed nondrug (food) reinforcer. The present experiment examined the reverse situation: choice between immediate nondrug (food) and delayed drug (cocaine) reinforcers. Whereas the former choice situation exemplifies drug abuse from a delay-discounting perspective, our interest in the latter choice situation is derived from the observation that drug abusers, who characteristically are associated with impulsive choice, typically must devote considerable time to procuring drugs, often at the expense of immediate nondrug alternatives...
December 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27929347/comparing-exponential-and-exponentiated-models-of-drug-demand-in-cocaine-users
#18
Justin C Strickland, Joshua A Lile, Craig R Rush, William W Stoops
Drug purchase tasks provide rapid and efficient measurement of drug demand. Zero values (i.e., prices with zero consumption) present a quantitative challenge when using exponential demand models that exponentiated models may resolve. We aimed to replicate and advance the utility of using an exponentiated model by demonstrating construct validity (i.e., association with real-world drug use) and generalizability across drug commodities. Participants (N = 40 cocaine-using adults) completed Cocaine, Alcohol, and Cigarette Purchase Tasks evaluating hypothetical consumption across changes in price...
December 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27929346/individual-differences-in-the-reinforcing-and-subjective-effects-of-d-amphetamine-dimensions-of-impulsivity
#19
Arit Harvanko, Catherine Martin, Joshua Lile, Richard Kryscio, Thomas H Kelly
Previous research has shown a relationship between impulsive personality and the subjective and reinforcing effects of d-amphetamine. Impulsive personality, however, is comprised of multiple dimensions. The association between different dimensions of impulsive personality and the subjective and reinforcing effects of d-amphetamine is unknown. The objective of this study was to assess the independent contributions of the "sensation-seeking" and "impulsivity" dimensions of the impulsive sensation-seeking subscale of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) to the subjective and reinforcing effects of d-amphetamine...
December 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27929345/directed-forgetting-of-memories-in-cocaine-users
#20
Manuel J Ruiz, Daniela Paolieri, Lorenza S Colzato, María Teresa Bajo
Memory retrieval requires an effective recruitment of inhibitory control to successfully reject unnecessary memories. The use of cocaine is associated with poor cognitive control processes, but little is known about the impact of chronic and recreational use of cocaine on inhibitory control during intentional forgetting. We studied whether chronic and recreational users of cocaine show impairments on the mechanism responsible for intentional forgetting of memories. Two experiments were carried out on chronic cocaine users in rehabilitation (Experiment 1) and recreational cocaine polydrug users (Experiment 2) performing a directed forgetting (DF) task, an index of memory suppression...
December 2016: Experimental and Clinical Psychopharmacology
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