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Experimental and Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/29048191/risperidone-in-combination-with-other-drugs-experimental-research-in-individuals-with-autism-spectrum-disorder
#1
Anita Li, Brian MacNeill, Hugo Curiel, Alan Poling
Many individuals with autism spectrum disorder simultaneously receive 2 or more drugs intended to improve their behavior, but few studies have evaluated the effects of such polypharmacy. This article summarizes those studies that have systematically examined the effects of risperidone, an antipsychotic drug that is approved by the U.S. Food and Drug Administration to treat "irritability" in children and adolescents with autism spectrum disorder, in combination with another drug with respect to experimental design, assessment techniques, drug co-administered, reported effects, and participant characteristics...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048190/the-efficacy-and-tolerability-of-paliperidone-in-mania-of-bipolar-disorder-a-preliminary-meta-analysis
#2
Han-Yung Chang, Ping-Tao Tseng, Brendon Stubbs, Che-Sheng Chu, Dian-Jeng Li, Michele Fornaro, Andre Carvalho, Marco Solmi, Nicola Veronese, Eduard Vieta, Tien-Yu Chen, Yen-Wen Chen, Pao-Yen Lin, Philip Chik-Keung Chow
Paliperidone may be effective for the treatment of bipolar disorder (BD); however, the evidence has been mixed. This is the first meta-analysis to evaluate the efficacy, safety, and tolerability of paliperidone for the treatment of BD. We performed a systematic search of the literature using major electronic databases from inception to January 27, 2017. Randomized control trials (RCTs) investigating paliperidone treatment among patients with BD versus a placebo or other second-generation antipsychotics were included...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048189/sex-related-marijuana-expectancies-as-predictors-of-sexual-risk-behavior-following-smoked-marijuana-challenge
#3
Linda M Skalski, Rachel L Gunn, Amy Caswell, Stephen Maisto, Jane Metrik
Marijuana use has been associated with sexual risk behavior, but the mechanisms that underlie this relationship are not well understood. The present study examined whether marijuana acutely increased sexual risk on a behavioral decision-making task and whether sex-related marijuana outcome expectancies influenced sexual risk decisions after marijuana administration. Participants were heterosexual marijuana users (n = 126) who were randomly assigned to 1 of 4 study conditions using a 2 × 2 factorial design crossing drug administration (received 2...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048188/effects-of-environmental-enrichment-on-d-amphetamine-self-administration-following-nicotine-exposure
#4
Dustin J Stairs, Sarah E Ewin, Megan M Kangiser, Markus N Pfaff
Adolescent nicotine exposure has been shown to lead to further psychostimulant use in adulthood. Previous preclinical research in rats has shown that environmental enrichment may protect against drug abuse vulnerability. The current study was designed to examine whether environmental enrichment can block the ability of adolescent nicotine exposure to increase d-amphetamine self-administration in adulthood. Male Sprague-Dawley rats were raised in either enriched conditions (ECs) or isolated conditions (ICs) and then injected with saline or nicotine (0...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048187/electronic-cigarette-user-plasma-nicotine-concentration-puff-topography-heart-rate-and-subjective-effects-influence-of-liquid-nicotine-concentration-and-user-experience
#5
Marzena Hiler, Alison Breland, Tory Spindle, Sarah Maloney, Thokozeni Lipato, Nareg Karaoghlanian, Alan Shihadeh, Alexa Lopez, Carolina Ramôa, Thomas Eissenberg
Electronic cigarette (ECIG) nicotine delivery and other effects may depend on liquid nicotine concentration and user experience. This study is the first to systematically examine the influence of ECIG liquid nicotine concentration and user experience on nicotine delivery, heart rate, puff topography, and subjective effects. Thirty-three ECIG-experienced individuals and 31 ECIG-naïve cigarette smokers completed 4 laboratory conditions consisting of 2, 10-puff bouts (30-sec interpuff interval) with a 3.3-V ECIG battery attached to a 1...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048186/toward-a-laboratory-model-for-psychotherapeutic-treatment-screening-implementation-intentions-and-incentives-for-abstinence-in-an-analog-of-smoking-relapse
#6
Lara N Moody, Lindsey M Poe, Warren K Bickel
Despite reductions in cigarette smoking in the United States, approximately 40 million Americans are smokers. Innovative interventions are needed to help remaining smokers quit. To develop innovative interventions, precise and effective tools are needed. Here, a laboratory model of smoking relapse is assessed for its ability to detect increased resistance to smoking across 2 interventions and for its sensitivity to differing degrees of effectiveness. Nicotine-deprived participants (N = 36) completed, in randomized order, 4 smoking resistance sessions with and without implementation intentions and monetary incentives...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048185/impulsivity-and-approach-tendencies-towards-cigarette-stimuli-implications-for-cigarette-smoking-and-cessation-behaviors-among-youth
#7
Hanna Weckler, Grace Kong, Helle Larsen, Janna Cousijn, Reinout W Wiers, Suchitra Krishnan-Sarin
Impulsivity is associated with smoking, difficulties quitting smoking, and approach tendencies toward cigarette stimuli among adolescents. We examined the effects of impulsivity on (a) the association between approach tendencies and adolescents' smoking status and (b) the effectiveness of Cognitive Bias Modification (CBM), a smoking cessation intervention focused on changing approach tendencies, among adolescent smokers. We conducted a secondary analysis of evidence from 2 previous published studies: Study 1: a cross-sectional study comparing impulsivity and approach tendencies between adolescent smokers (n = 67) and nonsmokers (n = 58); Study 2: a treatment study that randomized 60 adolescent smokers to receive either CBM or sham training...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048184/association-of-nicotine-metabolism-and-sex-with-relapse-following-varenicline-and-nicotine-replacement-therapy
#8
Anaïs Glatard, Maria Dobrinas, Mehdi Gholamrezaee, Rubin Lubomirov, Jacques Cornuz, Chantal Csajka, Chin B Eap
Nicotine is metabolized into cotinine and then into trans-3'-hydroxycotinine, mainly by cytochrome P450 2A6. Recent studies reported better effectiveness of varenicline in women and in nicotine normal metabolizers phenotypically determined by nicotine-metabolite ratio. Our objective was to study the influence of nicotine-metabolite ratio, CYP2A6 genotype and sex on the response to nicotine replacement therapy and varenicline. Data were extracted from a longitudinal study which included smokers participating in a smoking cessation program...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048183/an-initial-study-of-behavioral-addiction-symptom-severity-and-demand-for-indoor-tanning
#9
Amel Becirevic, Derek D Reed, Michael Amlung, James G Murphy, Jerod L Stapleton, Joel J Hillhouse
Indoor tanning remains a popular activity in Western cultures despite a growing body of literature suggesting its link to skin cancer and melanoma. Advances in indoor tanning research have illuminated problematic patterns of its use. With problems such as difficulty quitting, devoting resources toward its use at the expense of healthy activities, and excessive motivation and urges to tan, symptoms of excessive indoor tanning appear consistent with behavioral addiction. The present study bridges the gap between clinical approaches to understanding indoor tanning problems and behavioral economic considerations of unhealthy habits and addiction...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048182/differences-in-mood-and-cortisol-by-menstrual-phase-during-acute-smoking-abstinence-a-within-subject-comparison
#10
Samantha C Carlson, Alicia M Allen, Sharon S Allen, Mustafa al'Absi
There is evidence that smoking-cessation success differs by menstrual phase and sex hormone levels; however, the biological mechanisms underlying these differences are not clear. One possibility is that variation in cortisol throughout the menstrual cycle and early smoking abstinence may be partly responsible. The goal of this secondary-data analysis was to conduct a within-subject examination of the effects of menstrual phase and smoking abstinence on salivary cortisol and mood. Data are from a controlled crossover trial, in which participants completed 2 testing weeks during their follicular and luteal phases...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048181/an-open-label-pilot-study-of-an-intervention-using-mobile-phones-to-deliver-contingency-management-of-tobacco-abstinence-to-high-school-students
#11
Grace Kong, Alissa L Goldberg, Jesse Dallery, Suchitra Krishnan-Sarin
This pilot study assessed the feasibility, acceptability, and preliminary efficacy of a smoking cessation intervention that used mobile phones to remotely deliver reinforcements contingent on tobacco abstinence (contingency management [CM]) and weekly in-person cognitive-behavioral therapy to adolescent smokers. Daily adolescent smokers (N = 15; 12 completed study procedures, 3 dropped out) were recruited to participate in a 4-week study. During the first 2 weeks, daily text messages sent at random times prompted participants to transmit a video of themselves providing a carbon monoxide (CO) sample...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28910128/future-so-bright-delay-discounting-and-consideration-of-future-consequences-predict-academic-performance-among-college-drinkers
#12
Samuel F Acuff, Kathryn E Soltis, Ashley A Dennhardt, Brian Borsari, Matthew P Martens, James G Murphy
College student drinking is a major public health concern and can result in a range of negative consequences, from acute health risks to decreased academic performance and drop out. Harm reduction interventions have been developed to reduce problems associated with drinking but there is a need to identify specific risk/protective factors related to academic performance among college drinkers. Behavioral economics suggests that chronic alcohol misuse reflects a dysregulated behavioral process or reinforcer pathology-alcohol is overvalued and the value of prosocial rewards are sharply discounted due, in part, to their delay...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28782983/neurocognitive-dysfunction-in-addiction-testing-hypotheses-of-diffuse-versus-selective-phenotypic-dysfunction-with-a-classification-based-approach
#13
Warren K Bickel, Lara N Moody, Celia R Eddy, Christopher T Franck
Neurocognitive dysfunctions are frequently identified in the addictions. These dysfunctions may indicate either diffuse dysfunction or may represent separate facets that have differential importance to the addiction phenotype. In a sample (n = 260) of alcohol and/or stimulant users and controls we measured responses across 7 diverse neurocognitive measures. These measures were Continuous Performance, Delay Discounting, Iowa Gambling, Stroop, Tower, Wisconsin Card Sorting, and Letter Number Sequencing. Comparisons were then made between the drug-dependent groups and controls using analysis of variance and also using a machine learning approach to classify participants based on task performance as substance-dependent or controls in 1 tree and as alcohol and/or stimulant users or controls in a second tree...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28782982/sleep-continuity-architecture-and-quality-among-treatment-seeking-cannabis-users-an-in-home-unattended-polysomnographic-study
#14
Lauren R Pacek, Evan S Herrmann, Michael T Smith, Ryan Vandrey
The objective of the study was to describe self-report and objectively measured sleep characteristics of adult treatment-seeking cannabis users. Study participants (n = 87) were adults who were screened for a 12-week outpatient cannabis treatment research program in Baltimore, MD. Participants completed objective and self-report measures of sleep quality. Data were analyzed for the sample overall and after stratifying by sex (54 men, 33 women). Participants were primarily urban, socioeconomically disadvantaged African Americans...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28682103/exercise-attenuates-negative-effects-of-abstinence-during-72-hours-of-smoking-deprivation
#15
COMPARATIVE STUDY
Cynthia A Conklin, Isabella Soreca, David J Kupfer, Yu Cheng, Ronald P Salkeld, Joel M Mumma, John M Jakicic, Christopher J Joyce
Exercise is presumed to be a potentially helpful smoking cessation adjunct reputed to attenuate the negative effects of deprivation. The present study examined the effectiveness of moderate within-session exercise to reduce 4 key symptoms of smoking deprivation during 3 72-hr nicotine abstinence blocks in both male and female smokers. Forty-nine (25 male, 24 female) sedentary smokers abstained from smoking for 3 consecutive days on 3 separate occasions. At each session, smokers' abstinence-induced craving, cue-induced craving, negative mood, and withdrawal symptom severity were assessed prior to and after either exercise (a...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28682102/the-effects-of-cannabidiol-cbd-on-%C3%AE-%C3%A2-tetrahydrocannabinol-thc-self-administration-in-male-and-female-long-evans-rats
#16
Alison G P Wakeford, Bradley B Wetzell, Rebecca L Pomfrey, Matthew M Clasen, William W Taylor, Briana J Hempel, Anthony L Riley
Despite widespread cannabis use in humans, few rodent models exist demonstrating significant Δ⁹-tetrahydrocannabinol (THC) self-administration, possibly due to THC's co-occurring aversive effects, which impact drug reinforcement. Cannabis contains a number of phytocannabinoids in addition to THC, one of which, cannabidiol (CBD), has been reported to antagonize some of the aversive effects of THC. Given such effects of CBD, it is possible that it might influence THC intravenous self-administration in rodents...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28682101/premenstrual-symptoms-and-factors-implicated-in-smoking-cessation-among-woman-smokers
#17
Raina D Pang, Nafeesa Andrabi, Adam M Leventhal
Premenstrual symptoms (PMS) may reduce smoking cessation success. Yet, little is known about the factors that may impact smoking cessation among women with elevated PMS, leaving little data to guide smoking cessation science and practice for this population. This cross-sectional study is a secondary analysis of data from laboratory studies focused on menstrual cycle effects and smoking. Premenopausal woman daily smokers (n = 157) completed self-report measures of tobacco dependence and other cessation-relevant factors (i...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28650184/effects-of-nicotine-versus-placebo-e-cigarette-use-on-symptom-relief-during-initial-tobacco-abstinence
#18
Kenneth A Perkins, Joshua L Karelitz, Valerie C Michael
Because electronic cigarettes (e-cigs) containing nicotine may relieve smoking abstinence symptoms similar to nicotine replacement therapy medication, we used within-subjects designs to test these effects with a first-generation e-cig in nonquitting and quitting smokers. In Study 1, 28 nontreatment-seeking smokers abstained overnight prior to each of 3 sessions. Minnesota Nicotine Withdrawal Scale (MNWS) withdrawal (and craving item) relief was assessed following 4 exposures (each 10 puffs) over 2 hr to e-cigs that either did (36 mg/ml) or did not (i...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28627928/craving-and-acute-effects-of-alcohol-in-youths-daily-lives-associations-with-alcohol-use-disorder-severity
#19
Hayley Treloar, Robert Miranda
Identifying factors associated with the progression from recreational to pathological drinking in youth holds high clinical and theoretical importance. The present study tested cross-sectional associations of alcohol use disorder (AUD) severity with putative mechanisms of AUD progression among youth ages 15-24 years, namely acute subjective effects of alcohol and craving. Male (n = 44) and female (n = 42) youth completed ecological momentary assessments when not drinking, just before drinking, and while drinking in the natural environment via handheld wireless devices...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28627927/a-reinforcement-sensitivity-model-of-affective-and-behavioral-dysregulation-in-marijuana-use-and-associated-problems
#20
Noah N Emery, Jeffrey S Simons
This study tested a model linking sensitivity to punishment (SP) and reward (SR) to marijuana use and problems via affect lability and poor control. A 6-month prospective design was used in a sample of 2,270 young-adults (64% female). The hypothesized SP × SR interaction did not predict affect lability or poor control, but did predict use likelihood at baseline. At low levels of SR, SP was associated with an increased likelihood of abstaining, which was attenuated as SR increased. SP and SR displayed positive main effects on both affect lability and poor control...
August 2017: Experimental and Clinical Psychopharmacology
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