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Drug Delivery

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https://www.readbyqxmd.com/read/29791258/licorice-root-extract-and-magnesium-isoglycyrrhizinate-protect-against-triptolide-induced-hepatotoxicity-via-up-regulation-of-the-nrf2-pathway
#1
Qin-You Tan, Qian Hu, Sheng-Nan Zhu, Lu-Lu Jia, Juan Xiao, Hua-Zhen Su, Shao-Yuan Huang, Jing Zhang, Junfei Jin
Triptolide, the predominant biologically active component of the Chinese herb Tripterygium wilfordii Hook f., possesses numerous pharmacological activities, including anti-inflammatory, anti-fertility, anti-neoplastic, and immunosuppressive effects. However, toxicity and severe adverse effects, particularly hepatotoxicity, limit the clinical application of triptolide. Licorice root extract contains various bioactive compounds and is potent hepatoprotective. Magnesium isoglycyrrhizinate, a magnesium salt of the 18α-glycyrrhizic acid stereoisomer of glycyrrhizic acid, is used clinically in China to treat chronic viral hepatitis and acute drug-induced liver injury...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29791242/liver-targeted-delivery-of-insulin-loaded-nanoparticles-via-enterohepatic-circulation-of-bile-acids
#2
Zhe Zhang, Hongxiang Li, Guangrui Xu, Ping Yao
Liver is the primary acting site of insulin. In this study, we developed innovative nanoparticles for oral and liver-targeted delivery of insulin by using enterohepatic circulation of bile acids. The nanoparticles were produced from cholic acid and quaternary ammonium modified chitosan derivative and hydroxypropyl methylcellulose phthalate (HPMCP). The nanoparticles had a diameter of 239 nm, an insulin loading efficiency of 90.9%, and a loading capacity of 18.2%. Cell culture studies revealed that the cholic acid groups effectively enhanced the transport of the nanoparticles through Caco-2 cell monolayer and greatly increased the absorption of the nanoparticles in HepG-2 cells via bile acid transporter mechanism...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29791241/neutrophil-mediated-delivery-of-pixantrone-loaded-liposomes-decorated-with-poly-sialic-acid-octadecylamine-conjugate-for-lung-cancer-treatment
#3
Xiang Luo, Ling Hu, Huangliang Zheng, Mingqi Liu, Xinrong Liu, Cong Li, Qiujun Qiu, Zitong Zhao, Xiaobo Cheng, Chaoyang Lai, Yuqing Su, Yihui Deng, Yanzhi Song
Poly(sialic acid) (PSA) is a natural hydrophilic biodegradable and non-immunogenic biopolymer, receptors for its monomer are expressed on peripheral blood neutrophils (PBNs), which plays important roles in the progression and invasion of tumors. A poly(sialic acid)-octadecylamine conjugate (PSA-ODA) was synthesized and then anchor it on the surface of liposomal pixantrone (Pix-PSL), to achieve an improved anticancer effect. The liposomes were prepared using a remote loading method via a pH gradient, and then assessed for particle size, zeta potential encapsulation efficiency, in vitro release, and in vitro cytotoxicity...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29790376/plateau-hypoxia-attenuates-the-metabolic-activity-of-intestinal-flora-to-enhance-the-bioavailability-of-nifedipine
#4
Juanhong Zhang, Yuyan Chen, Yuemei Sun, Rong Wang, Junmin Zhang, Zhengping Jia
Nifedipine is completely absorbed by the gastrointestinal tract and its pharmacokinetics and metabolism may be influenced by microorganisms. If gut microbes are involved in the metabolism of nifedipine, plateau hypoxia may regulate the bioavailability and the therapeutic effect of nifedipine by altering the metabolic activity of the gut microbiota. We herein demonstrated for the first time that gut flora is involved in the metabolism of nifedipine by in vitro experiments. In addition, based on the results of 16S rRNA analysis of feces in rats after acute plateau, we first confirmed that the plateau environment could cause changes in the number and composition of intestinal microbes...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29790374/hybrid-liposomes-showing-enhanced-accumulation-in-tumors-as-theranostic-agents-in-the-orthotopic-graft-model-mouse-of-colorectal-cancer
#5
Masaki Okumura, Hideaki Ichihara, Yoko Matsumoto
Hybrid liposomes (HLs) can be prepared by simply sonicating a mixture of vesicular and micellar molecules in a buffer solution. This study aimed to elucidate the therapeutic effects and ability of HLs to detect (diagnosis) cancer in an orthotopic graft mouse model of colorectal cancer with HCT116 cells for the use of HLs as theranostic agents. In the absence of a chemotherapeutic drug, HLs exhibited therapeutic effects by inhibiting the growth of HCT116 colorectal cancer cells in vitro, possibly through an increase in apoptosis...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29790372/folate-receptor-targeted-mixed-polysialic-acid-micelles-for-combating-rheumatoid-arthritis-in-vitro-and-in-vivo-evaluation
#6
Nan Zhang, Chunyu Xu, Na Li, Shasha Zhang, Lingling Fu, Xiao Chu, Haiying Hua, Xianghui Zeng, Yongxing Zhao
OBJECTIVE: Rheumatoid arthritis (RA) is associated with chronic inflammation. The suppression of inflammation is key to the treatment of RA. Glucocorticoids (GCs) are classical anti-inflammatory drugs with several disadvantages such as poor water solubility and low specificity in the body. These disadvantages are the reasons for the quick elimination and side effects of GCs in vivo. Micelles are ideal carriers for GCs delivery to inflamed synovium. We set out to improve the targeting and pharmacokinetic profiles of GCs by preparing a targeting micelle system...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29781340/graphene-oxide-enhances-alginate-encapsulated-cells-viability-and-functionality-while-not-affecting-the-foreign-body-response
#7
Jesús Ciriza, Laura Saenz Del Burgo, Haritz Gurruchaga, Francesc E Borras, Marcella Franquesa, Gorka Orive, Rosa Maria Hernández, José Luis Pedraz
The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach in cell microencapsulation represents a great promise for long-term drug delivery, previous studies have been performed only with encapsulated murine C2 C12 myoblasts genetically engineered to secrete murine erythropoietin (C2 C12 -EPO) within 160 µm diameter hybrid alginate protein-coated GO microcapsules implanted into syngeneic mice...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29781332/a-novel-phenolic-propanediamine-moiety-based-lung-targeting-therapy-for-asthma
#8
Jianbo Li, Yang Yang, Didi Wan, Youmei Peng, Jinjie Zhang
Asthma is one of the most prevalent chronic inflammatory diseases of lung. Current asthma therapy using inhaled corticosteroid often results in undesired treatment outcome due to poor compliance and drugs' lack of tissue specificity. N,N,N'-trimethyl-N'-(2-hydroxyl-3-methyl-5-123 Iiodobenzyl)-1,3-propanediamine (HIPD), a phenolic propanediamine derivative, has been used as an imaging agent for localized pulmonary diseases. Inspired by this, N,N,N'-trimethyl-N'-(4-hydroxyl-benzyl)-1,3-propanediamine (TPD), a new HIPD analog, was proposed as a lung-targeting ligand and covalently conjugated to an anti-inflammatory compound Rhein for asthma therapy...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29779406/inhalation-delivery-of-topotecan-is-superior-to-intravenous-exposure-for-suppressing-lung-cancer-in-a-preclinical-model
#9
Philip J Kuehl, Marcie J Grimes, Devon Dubose, Michael Burke, David A Revelli, Andrew P Gigliotti, Steven A Belinsky, Mathewos Tessema
Intravenous (IV) topotecan is approved for the treatment of various malignancies including lung cancer but its clinical use is greatly undermined by severe hematopoietic toxicity. We hypothesized that inhalation delivery of topotecan would increase local exposure and efficacy against lung cancer while reducing systemic exposure and toxicity. These hypotheses were tested in a preclinical setting using a novel inhalable formulation of topotecan against the standard IV dose. Respirable dry-powder of topotecan was manufactured through spray-drying technology and the pharmacokinetics of 0...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29779394/preparation-of-a-mesoporous-silica-based-nano-vehicle-for-dual-dox-cpt-ph-triggered-delivery
#10
Maria C Llinàs, Gabriel Martínez-Edo, Anna Cascante, Irene Porcar, Salvador Borrós, David Sánchez-García
A dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalized MSN through a dihydrazide-polyethylene glycol chain. Thus, DOX and the linker act as pH-sensitive gatekeeper. The system is versatile and easy to assemble, not requiring the chemical modification of the drugs. While at physiological conditions the release of the drugs is negligible, at acidic pH a burst release of DOX and a gradual release of CPT take place...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29742945/sericin-nanomicelles-with-enhanced-cellular-uptake-and-ph-triggered-release-of-doxorubicin-reverse-cancer-drug-resistance
#11
Weihong Guo, Lizhi Deng, Jiang Yu, Zhaoyu Chen, Yanghee Woo, Hao Liu, Tuanjie Li, Tian Lin, Hao Chen, Mingli Zhao, Liming Zhang, Guoxin Li, Yanfeng Hu
Drug resistance is the major challenge facing cancer chemotherapy and nanoscale delivery systems based on natural materials, such as sericin, are a promising means of overcoming drug resistance. Yet, no attempt of introducing synthetic poly(γ-benzyl-L-glutamate) (PBLG) onto sericin polypeptide to fabricate a facile biocompatible and biodegradable micelle has been tried. Here, we prepared a polypeptide-based amphiphilic polymer containing hydrophilic sericin polypeptide backbone and PBLG side chains via ring-opening polymerization (ROP) strategy...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29726297/glioma-targeting-peptide-modified-apoferritin-nanocage
#12
Meifang Zhai, Yuli Wang, Ligang Zhang, Meng Liang, Shiyao Fu, Lin Cui, Meiyan Yang, Wei Gong, Zhiping Li, Lian Yu, Xiangyang Xie, Chunrong Yang, Yang Yang, Chunsheng Gao
Therapeutic outcome for the treatment of glioma was often limited due to the non-targeted nature of drugs and the physiological barriers, including the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB). An ideal glioma-targeted delivery system must be sufficiently potent to cross the BBB and BBTB and then target glioma cells with adequate optimized physiochemical properties and biocompatibility. However, it is an enormous challenge to the researchers to engineer the above-mentioned features into a single nanocarrier particle...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29722585/drug-delivery-systems-based-on-biocompatible-imino-chitosan-hydrogels-for-local-anticancer-therapy
#13
Daniela Ailincai, Liliana Tartau Mititelu, Luminita Marin
A series of drug delivery systems were prepared by chitosan hydrogelation with citral in the presence of an antineoplastic drug: 5-fluorouracil. The dynamic covalent chemistry of the imine linkage allowed the obtaining of supramolecular tridimensional architectures in which the drug has been homogenously dispersed. Fourier-transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WXRD) and polarized light microscopy (POM) measurements were used in order to follow the hydrogelation and drug encapsulation processes...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29718725/bispecific-antibodies-anti-mpeg-anti-her2-for-active-tumor-targeting-of-docetaxel-dtx-loaded-mpegylated-nanocarriers-to-enhance-the-chemotherapeutic-efficacy-of-her2-overexpressing-tumors
#14
Chia-Yu Su, Michael Chen, Ling-Chun Chen, Yuan-Soon Ho, Hsiu-O Ho, Shyr-Yi Lin, Kuo-Hsiang Chuang, Ming-Thau Sheu
Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (Lsb MDDs) were endowed with active targetability to improve the chemotherapeutic efficacy of DTX. DTX-loaded mPEGylated Lsb MDDs formulations were prepared using lecithin/DSPE-PEG(2K or 5K) nanosuspensions to hydrate the thin film, and then they were subjected to ultrasonication. Two BsAbs (anti-mPEG/anti-DNS or anti-HER2) were simply mixed with the Lsb MDDs to form BsAbs-Lsb MDDs formulations, respectively, referred as the DNS-Lsb MDDs and HER2-Lsb MDDs...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29695174/preparation-of-psoralen-polymer-lipid-hybrid-nanoparticles-and-their-reversal-of-multidrug-resistance-in-mcf-7-adr-cells
#15
Qingqing Huang, Tiange Cai, Qianwen Li, Yinghong Huang, Qian Liu, Bingyue Wang, Xi Xia, Qi Wang, John C C Whitney, Susan P C Cole, Yu Cai
Multidrug resistance (MDR) is the leading cause of failure for breast cancer in the clinic. Thus far, polymer-lipid hybrid nanoparticles (PLN) loaded chemotherapeutic agents has been used to overcome MDR in breast cancer. In this study, we prepared psoralen polymer-lipid hybrid nanoparticles (PSO-PLN) to reverse drug resistant MCF-7/ADR cells in vitro and in vivo. PSO-PLN was prepared by the emulsification evaporation-low temperature solidification method. The formulation, water solubility and bioavailability, particle size, zeta potential and entrapment efficiency, and in vitro release experiments were optimized in order to improve the activity of PSO to reverse MDR...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29688087/modification-of-translationally-controlled-tumor-protein-derived-protein-transduction-domain-for-improved-intranasal-delivery-of-insulin
#16
Hae-Duck Bae, Joohyun Lee, Kyu-Yeon Jun, Youngjoo Kwon, Kyunglim Lee
Carrier peptides, termed protein transduction domains (PTDs), serve as provide promising vehicles for intranasal delivery of macromolecular drugs. A mutant PTD derived from human translationally controlled tumor protein (TCTP-PTD 13, MIIFRALISHKK) was reported to provide enhanced intranasal delivery of insulin. In this study, we tested whether its efficiency could be further improved by replacing amino acids in TCTP-PTD 13 or changing the amino acids in the carrier peptides from the l- to the d-form. We assessed the pharmacokinetics of PTD-mediated transmucosal delivery of insulin in normal rats and the activity of insulin in alloxan-induced diabetic rats...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29688083/localized-delivery-of-therapeutic-doxorubicin-dose-across-the-canine-blood-brain-barrier-with-hyperthermia-and-temperature-sensitive-liposomes
#17
Amy Lee Bredlau, Anjan Motamarry, Chao Chen, M A McCrackin, Kris Helke, Kent E Armeson, Katrina Bynum, Ann-Marie Broome, Dieter Haemmerich
Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to hyperthermia (>40 °C). Since hyperthermia also transiently opens the BBB, we hypothesized that localized hyperthermia can achieve drug delivery across the BBB when combined with TSL. TSL-encapsulated doxorubicin (TSL-Dox) was infused intravenously over 30 min at a dose of 0...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29688069/development-of-kupffer-cell-targeting-type-i-interferon-for-the-treatment-of-hepatitis-via-inducing-anti-inflammatory-and-immunomodulatory-actions
#18
Yuki Minayoshi, Hitoshi Maeda, Hiroki Yanagisawa, Keisuke Hamasaki, Yuki Mizuta, Kento Nishida, Ryo Kinoshita, Yuki Enoki, Tadasi Imafuku, Victor Tuan Giam Chuang, Tomoaki Koga, Yukio Fujiwara, Motohiro Takeya, Kayoko Sonoda, Tomohiko Wakayama, Kazuaki Taguchi, Yu Ishima, Tatsuhiro Ishida, Yasuko Iwakiri, Motohiko Tanaka, Yutaka Sasaki, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of hepatitis. We report herein on the preparation of a Kupffer cell targeting type-I interferon, an albumin-IFNα2b fusion protein that contains highly mannosylated N-linked oligosaccharide chains, Man-HSA(D494N)-IFNα2b, attached by combining albumin fusion technology and site-directed mutagenesis...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29667478/retro-inverso-follicle-stimulating-hormone-peptide-mediated-polyethylenimine-complexes-for-targeted-ovarian-cancer-gene-therapy
#19
Mengyu Zhang, Mingxing Zhang, Jing Wang, Qingqing Cai, Ran Zhao, Yi Yu, Haiyan Tai, Xiaoyan Zhang, Congjian Xu
BACKGROUND: The development of nanoparticle drug delivery systems with targeted ligands has the potential to increase treatment efficiency in ovarian cancer. METHODS: We developed a 21-amino acid peptide, YTRDLVYGDPARPGIQGTGTF (L-FP21) conjugated to polyethylenimine (PEI) and methoxy polyethylene glycol (mPEG) to prepare a nanoparticle drug vehicle to target follicle-stimulating hormone receptor (FSHR) in ovarian cancer. At the same time, we optimized the ligand of the nanoparticle vehicle using D-peptides, which consist of D-amino acids (D-FP21)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29667446/intra-articular-injection-of-kartogenin-conjugated-polyurethane-nanoparticles-attenuates-the-progression-of-osteoarthritis
#20
Wenshuai Fan, Jinghuan Li, Liu Yuan, Jifei Chen, Zhe Wang, Yiming Wang, Changan Guo, Xiumei Mo, Zuoqin Yan
Osteoarthritis (OA) is the most common form of joint disease and a leading cause of physical disability, there is an urgent need to attenuate the progression of OA. Intra-articular (IA) injection is an effective treatment for joints diseases, however, the therapeutic effects mostly depend on the efficacy of drug duration in joints. Drug delivery system can provide drug-controlled release and reduce the number of IA injection. In this study, amphiphilic polyurethanes with pendant amino group were synthesized and amide bonds were formed between the amine group of polyurethane and the carboxyl group of kartogenin (KGN), a small molecular reported to show both regenerative and protective effects on cartilage...
November 2018: Drug Delivery
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