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Drug Delivery

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https://www.readbyqxmd.com/read/28691533/correction-to-zhang-etal-comparison-of-pharmacokinetics-and-drug-release-in-tissues-after-transarterial-chemoembolization-with-doxorubicin-using-diverse-lipiodol-emulsions-and-callispheres-beads-in-rabbit-livers
#1
https://www.readbyqxmd.com/read/28705021/atorvastatin-loaded-micelles-with-bone-targeted-ligand-for-the-treatment-of-osteoporosis
#2
Yonghui Xie, Xueying Tan, Jian Huang, Hongwei Huang, Ping Zou, Jingbo Hu
Osteoporosis is a common bone disorder where the declined bone mass is far more than normal physiological status and usually associated with enhanced fracture risk, reduced bone strength and even deteriorated quality of life. Recent studies showed that statins could exert beneficial effects on bones via promoting osteoblastic activity mediated by increased expression of bone morphogenetic protein 2 and also by suppressing osteoclast proliferation. In this study, we developed atorvastatin-loaded tetracycline-poly (ethylene glycol)-poly(lactic-co-glycolic acid) (TC-PEG-PLGA/ATO) micelles for the targeted treatment of osteoporosis...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28687053/fabrication-in-vitro-characterization-and-enhanced-in-vivo-evaluation-of-carbopol-based-nanoemulsion-gel-of-apigenin-for-uv-induced-skin-carcinoma
#3
Manmohan S Jangdey, Anshita Gupta, Swarnlata Saraf
The aim of this study was to develop a potential novel formulation of carbopol-based nanoemulsion gel containing apigenin using tamarind gum emulsifier which was having the smallest droplet size, the highest drug content, and a good physical stability for Skin delivery. Apigenin loaded nanoemulsion was prepared by high speed homogenization method and they were characterized with respect to morphology, zeta potential, differential scanning calorimeter study, and penetration studies. In-vitro release studies and skin permeation of apigenin loaded nanoemulsion by goat abdominal skin was determined using Franz diffusion cell and confocal laser scanning microscope (CLSM)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28687052/borneol-a-novel-agent-that-improves-central-nervous-system-drug-delivery-by-enhancing-blood-brain-barrier-permeability
#4
Qun-Lin Zhang, Bingmei M Fu, Zhang-Jin Zhang
The clinical application of central nervous system (CNS) drugs is limited by their poor bioavailability due to the blood-brain barrier (BBB). Borneol is a naturally occurring compound in a class of 'orifice-opening' agents often used for resuscitative purposes in traditional Chinese medicine. A growing body of evidence confirms that the 'orifice-opening' effect of borneol is principally derived from opening the BBB. Borneol is therefore believed to be an effective adjuvant that can improve drug delivery to the brain...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28687046/formulation-and-in-vitro-in-vivo-evaluation-of-chitosan-based-film-forming-gel-containing-ketoprofen
#5
Dong-Won Oh, Ji-Hyun Kang, Hyo-Jung Lee, Sang-Duk Han, Min-Hyung Kang, Yie-Hyuk Kwon, Joon-Ho Jun, Dong-Wook Kim, Yun-Seok Rhee, Ju-Young Kim, Eun-Seok Park, Chung-Woong Park
The film forming gel, adhered to skin surfaces upon application and formed a film, has an advantage onto skin to provide protection and continuous drug release to the application site. This study aimed to prepare a chitosan-based film forming gel containing ketoprofen (CbFG) and to evaluate the CbFG and film from CbFG (CbFG-film). CbFG were prepared with chitosan, lactic acid and various skin permeation enhancers. The physicochemical characteristics were evaluated by texture analysis, viscometry, SEM, DSC, XRD and FT-IR...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28687044/dual-modified-liposome-codelivery-of-doxorubicin-and-vincristine-improve-targeting-and-therapeutic-efficacy-of-glioma
#6
Yue Zhang, Meifang Zhai, Zhijiang Chen, Xiaoyang Han, Fanglin Yu, Zhiping Li, Xiangyang Xie, Cuiyan Han, Lian Yu, Yang Yang, Xingguo Mei
Therapeutic outcome for the treatment of glioma was often limited due to drug resistance and low permeability of drug across the multiple physiological barriers, including the blood-brain barrier (BBB), and the blood-tumor barrier (BTB). In order to overcome these hurdles, we designed T7 and (D)A7R dual peptides-modified liposomes (abbreviated as T7/(D)A7R-LS) to efficiently co-delivery doxorubicin (DOX) and vincristine (VCR) to glioma in this study. T7 is a seven-peptide ligand of transferrin receptors (TfR) capable of circumventing the BBB and then targeting glioma...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28675315/a-novel-solid-self-nanoemulsifying-drug-delivery-system-s-snedds-for-improved-stability-and-oral-bioavailability-of-an-oily-drug-1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol
#7
Kyeong Soo Kim, Eun Su Yang, Dong Shik Kim, Dong Wuk Kim, Hye Hyun Yoo, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Jun-Pil Jee, Jong Oh Kim, Sung Giu Jin, Han Gon Choi
To develop a novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for a water-insoluble oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) with improved stability and oral bioavailability, numerous S-SNEDDS were prepared with surfactant, hydrophilic polymer, antioxidant, and calcium silicate (porous carrier) using the spray-drying method. Their physicochemical properties were evaluated using emulsion droplet size analysis, SEM and PXRD. Moreover, the solubility, dissolution, stability, and pharmacokinetics of the selected S-SNEDDS were assessed compared with the drug and a commercial soft capsule...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28660787/comparison-of-pharmacokinetics-and-drug-release-in-tissues-after-transarterial-chemoembolization-with-doxorubicin-using-diverse-lipiodol-emulsions-and-callispheres-beads-in-rabbit-livers
#8
Shuisheng Zhang, Can Huang, Zhengzheng Li, Yongjie Yang, Tingting Bao, Haibo Chen, Yinghua Zou, Li Song
CalliSpheres(®) Beads (CB) is the first drug-eluting bead (DEB) product in China. Our aim was to compare the effect on the pharmacokinetics of doxorubicin (DOX) and its local concentration between lipiodol emulsions and CB in the process of TACE in rabbit livers. Twenty-five rabbits were distributed into two groups; Group 1 received lipiodol emulsions with DOX, and Group 2 received CB loaded with DOX (CBDOX). DOX was measured in the peripheral blood at different times after treatment. Livers were sampled at 1 week and 1 month for Group 2 after embolization...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28645219/pullulan-microbeads-si-hpmc-hydrogel-injectable-system-for-the-sustained-delivery-of-gdf-5-and-tgf-%C3%AE-1-new-insight-into-intervertebral-disc-regenerative-medicine
#9
Nina Henry, Johann Clouet, Audrey Fragale, Louise Griveau, Claire Chédeville, Joëlle Véziers, Pierre Weiss, Jean Le Bideau, Jérôme Guicheux, Catherine Le Visage
Discogenic low back pain is considered a major health concern and no etiological treatments are today available to tackle this disease. To clinically address this issue at early stages, there is a rising interest in the stimulation of local cells by in situ injection of growth factors targeting intervertebral disc (IVD) degenerative process. Despite encouraging safety and tolerability results in clinic, growth factors efficacy may be further improved. To this end, the use of a delivery system allowing a sustained release, while protecting growth factors from degradation appears of particular interest...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28644728/liposomes-equipped-with-cell-penetrating-peptide-br2-enhances-chemotherapeutic-effects-of-cantharidin-against-hepatocellular-carcinoma
#10
Xue Zhang, Congcong Lin, Aiping Lu, Ge Lin, Huoji Chen, Qiang Liu, Zhijun Yang, Hongqi Zhang
A main hurdle for the success of tumor-specific liposomes is their inability to penetrate tumors efficiently. In this study, we incorporated a cell-penetrating peptide BR2 onto the surface of a liposome loaded with the anticancer drug cantharidin (CTD) to create a system targeting hepatocellular carcinoma (HCC) cells more efficiently and effectively. The in vitro cytotoxicity assay comparing the loaded liposomes' effects on hepatocellular cancer HepG2 and the control Miha cells showed that CTD-loaded liposomes had a stronger anticancer effect after BR2 modification...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28644090/transdermal-administration-of-melatonin-coupled-to-cryopass-laser-treatment-as-noninvasive-therapy-for-prostate-cancer
#11
Laura Terraneo, Paola Bianciardi, Eleonora Virgili, Elena Finati, Michele Samaja, Rita Paroni
Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week melatonin (0.09 mg/mouse/week) delivered by i.p. injections, which is equivalent to a dose of 210 mg/week in humans. The aim of this study is to test an alternative noninvasive delivery route based on transdermal administration of melatonin onto the tumor area followed by cryopass-laser treatment...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28633548/polyquaternium-mediated-delivery-of-morpholino-oligonucleotides-for-exon-skipping-in-vitro-and-in-mdx-mice
#12
Mingxing Wang, Bo Wu, Sapana N Shah, Peijuan Lu, Qilong Lu
Antisense oligonucleotide therapy for Duchenne muscular dystrophy has shown great potential in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery. In this study, we investigated a few polyquaterniums (PQs) with different size and composition for their potential to improve delivery performance of an antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in vivo. The results showed that Luviquat(TM) series, especially PQ-1 and PQ-3, promoted the exon-skipping efficiency comparable to Endoporter-mediated PMO delivery in vitro...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28633547/lipid-based-nanosystem-of-edaravone-development-optimization-characterization-and-in-vitro-in-vivo-evaluation
#13
Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg, Xin-Fu Zhou
Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases including neurodegenerative disease, cardiovascular disease, and cancer. However, its oral use is restricted due to poor oral bioavailability (BA). The aim of present research was to enable its oral use by developing a lipid-based nanosystem (LNS). The components of LNS including oil, surfactants, and co-surfactants were selected based on their potential to maximize the solubilization in gastrointestinal (GI) fluids, reduce its glucuronidation and improve transmembrane permeability...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28618841/assessment-of-solid-microneedle-rollers-to-enhance-transmembrane-delivery-of-doxycycline-and-inhibition-of-mmp-activity
#14
Abbie Omolu, Maryse Bailly, Richard M Day
Many chronic wounds exhibit high matrix metalloproteinase (MMP) activity that impedes the normal wound healing process. Intradermal delivery (IDD) of sub-antimicrobial concentrations of doxycycline, as an MMP inhibitor, could target early stages of chronic wound development and inhibit further wound progression. To deliver doxycycline intradermally, the skin barrier must be disrupted. Microneedle rollers offer a minimally invasive technique to penetrate the skin by creating multiple microchannels that act as temporary conduits for drugs to diffuse through...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28617150/atorvastatin-loaded-nanostructured-lipid-carriers-nlcs-strategy-to-overcome-oral-delivery-drawbacks
#15
Mohammed Elmowafy, Hany M Ibrahim, Mohammed A Ahmed, Khaled Shalaby, Ayman Salama, Hossam Hefesha
Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NLCs) were prepared and characterized. AT-NLCs were prepared by emulsification using high-speed homogenization followed by ultrasonication. The prepared NLCs showed particle size between 162.5 ± 12 and 865...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28597700/engineering-of-a-novel-optimized-platform-for-sublingual-delivery-with-novel-characterization-tools-in-vitro-evaluation-and-in-vivo-pharmacokinetics-study-in-human
#16
Nadia M Morsi, Ghada A Abdelbary, Ahmed H Elshafeey, M Abdallah Ahmed
The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosphatidylinositol enriched soybean lecithin to form MSP-phospholipid complex (MSP-PLCP). Changes in physicochemical properties were assessed and the optimum MSP-PLCP formula was then used for formulation into a flushing resistant platform using two mucoadhesive polymers; sodium alginates and sodium carboxymethylcellulose at different concentrations...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28585867/characterization-of-transgene-expression-and-pdna-distribution-of-the-suctioned-kidney-in-mice
#17
Natsuko Oyama, Yuki Fuchigami, Shintaro Fumoto, Megumu Sato, Masayori Hagimori, Kazunori Shimizu, Shigeru Kawakami
We have previously developed an efficient and safe transfection method for the kidney in mice: renal suction-mediated transfection. In this study, we verified the detailed characteristics of transgene expression and plasmid DNA (pDNA) in mice to develop therapeutic strategies and application to gene function analysis in the kidney. After naked pDNA was administered intravenously, the right kidney was immediately suctioned by a tissue suction device. We examined the spatial distribution of transgene expression and pDNA in the suctioned kidney using tissue clearing by CUBIC, Clear(T2), and Scale SQ reagents...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28574335/toxicity-of-orally-inhaled-drug-formulations-at-the-alveolar-barrier-parameters-for-initial-biological-screening
#18
Eleonore Fröhlich
Oral delivery is the most common mode of systemic drug application. Inhalation is mainly used for local therapy of lung diseases but may also be a promising route for systemic delivery of drugs that have poor oral bioavailability. The thin alveolar barrier enables fast and efficient uptake of many molecules and could deliver small molecules and proteins, which are susceptible to degradation and show poor absorption by oral application. The low rate of biotransformation and proteolytic degradation increases bioavailability of drugs but accumulation of not absorbed material may impair normal lung function...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28574300/anti-cd123-antibody-modified-niosomes-for-targeted-delivery-of-daunorubicin-against-acute-myeloid-leukemia
#19
Fu-Rong Liu, Hui Jin, Yin Wang, Chen Chen, Ming Li, Sheng-Jun Mao, Qiantao Wang, Hui Li
A novel niosomal delivery system was designed and investigated for the targeted delivery of daunorubicin (DNR) against acute myeloid leukemia (AML). Anti-CD123 antibodies conjugated to Mal-PEG2000-DSPE were incorporated into normal niosomes (NS) via a post insertion method to afford antibody-modified niosomes (CD123-NS). Next, NS was modified with varying densities of antibody (0.5 or 2%, antibody/Span 80, molar ratio), thus providing L-CD123-NS and H-CD123-NS. We studied the effect of antibody density on the uptake efficiency of niosomes in NB4 and THP-1 cells, on which CD123 express differently...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28574291/temperature-sensitive-heparin-modified-poloxamer-hydrogel-with-affinity-to-kgf-facilitate-the-morphologic-and-functional-recovery-of-the-injured-rat-uterus
#20
He-Lin Xu, Jie Xu, Si-Si Zhang, Qun-Yan Zhu, Bing-Hui Jin, De-Li ZhuGe, Bi-Xin Shen, Xue-Qing Wu, Jian Xiao, Ying-Zheng Zhao
Endometrial injury usually results in intrauterine adhesion (IUA), which is an important cause of infertility and recurrent miscarriage in reproductive women. There is still lack of an effective therapeutic strategy to prevent occurrence of IUA. Keratinocyte growth factor (KGF) is a potent repair factor for epithelial tissues. Here, a temperature-sensitive heparin-modified poloxamer (HP) hydrogel with affinity to KGF (KGF-HP) was used as a support matrix to prevent IUA and deliver KGF. The rheology of KGF-HP hydrogel was carefully characterized...
November 2017: Drug Delivery
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