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Drug Delivery

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https://www.readbyqxmd.com/read/29260902/correction-to-el-housiny-et%C3%A2-al-fluconazole-loaded-solid-lipid-nanoparticles-topical-gel-for-treatment-of-pityriasis-versicolor-formulation-and-clinical-study
#1
(no author information available yet)
No abstract text is available yet for this article.
December 20, 2017: Drug Delivery
https://www.readbyqxmd.com/read/29198149/correction-to-tan-et-al-recent-developments-in-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-based-nanomedicine-for-cancer-therapy
#2
(no author information available yet)
No abstract text is available yet for this article.
December 4, 2017: Drug Delivery
https://www.readbyqxmd.com/read/29069936/correction-to-dong-et%C3%A2-al-promising-galactose-decorated-biodegradable-poloxamer-188-plga-diblock-copolymer-nanoparticles-of-resibufogenin-for-enhancing-liver-cancer-therapy
#3
(no author information available yet)
No abstract text is available yet for this article.
October 25, 2017: Drug Delivery
https://www.readbyqxmd.com/read/29334814/dual-ligand-modified-liposomes-provide-effective-local-targeted-delivery-of-lung-cancer-drug-by-antibody-and-tumor-lineage-homing-cell-penetrating-peptide
#4
Congcong Lin, Xue Zhang, Hubiao Chen, Zhaoxiang Bian, Ge Zhang, Muhammad Kashif Riaz, Deependra Tyagi, Ge Lin, Yanbo Zhang, Jinjin Wang, Aiping Lu, Zhijun Yang
The abilities of a drug delivery system to target and penetrate tumor masses are key factors in determining the system's chemotherapeutic efficacy. Here, we explored the utility of an anti-carbonic anhydrase IX (anti-CA IX) antibody and CPP33 dual-ligand modified triptolide-loaded liposomes (dl-TPL-lip) to simultaneously enhance the tumor-specific targeting and increase tumor cell penetration of TPL. In vitro, the dl-TPL-lip increased the cytotoxicity of TPL in CA IX-positive lung cancer cells, which showed tunable size (137...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29334805/delivery-of-radix-ophiopogonis-polysaccharide-via-sucrose-acetateisobutyrate-based-in-situ-forming-systems-alone-or-combined-with-itsmono-pegylation
#5
LiNa Wang, Xiao Zheng, Fei Wu, Lan Shen, Xiao Lin, Yi Feng
This work aimed to achieve long-lasting delivery of radix ophiopogonis polysaccharide (ROP) by sucrose acetate isobutyrate (SAIB)-based in situ forming systems (ISFSs) alone or combined with mono-PEGylation of ROP. When the '90%SAIB/10% solvent' system was used, the mean residence time (MRT) of ROP was prolonged by 4.3 5 ∼ 7.00 times and the initial release rate was reduced significantly. However, this system was only suitable for days-long sustained release of ROP in short-term therapy. As to the 'SAIB/additives/solvent' system containing mono-PEGylated ROP, the results indicated that SAIB/poly(d,l-lactide-co-glycolide) (PLGA)/N-methyl-2-pyrrolidone (NMP) was superior to SAIB/polylactic acid (PLA)/NMP and SAIB/PLA/ethanol in controlled release...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29334800/research-progress-of-self-assembled-nanogel-and-hybrid-hydrogel-systems-based-on-pullulan-derivatives
#6
Tao Zhang, Ruyi Yang, Shengnan Yang, Jibin Guan, Dong Zhang, Yan Ma, Hongzhuo Liu
Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and 'switch-on/off' mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29334793/controlled-synthesis-and-size-effects-of-multifunctional-mesoporous-silica-nanosystem-for-precise-cancer-therapy
#7
Bin Ma, Lizhen He, Yuanyuan You, Jianbin Mo, Tianfeng Chen
Nanomaterials-based drug delivery systems display potent applications in cancer therapy, owing to the enhanced permeability and retention effect and diversified chemical modification. In this study, we have tailored and synthesized different sized mesoporous silica nanoparticles (MSNs) through reactant control to investigate the relevancy of nanoparticle size toward anticancer efficacy and suppressing cancer multidrug resistance. The different sized MSNs loaded with anticancer ruthenium complex (RuPOP) and conjugated with folate acid (FA) to enhance the selectivity between cancer and normal cells...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29334272/extracellular-vesicle-mimetic-nanovesicles-transport-lncrna-h19-as-competing-endogenous-rna-for-the-treatment-of-diabetic-wounds
#8
Shi-Cong Tao, Bi-Yu Rui, Qi-Yang Wang, Ding Zhou, Yang Zhang, Shang-Chun Guo
Diabetic wounds, one of the most enervating complications of diabetes mellitus, affect millions of people worldwide annually. Vascular insufficiency, caused by hyperglycemia, is one of the primary causes and categories of diabetic impaired wound healing. Recently, long noncoding RNA (LncRNA)-H19, which is significantly decreased in diabetes and may be crucial in triggering angiogenesis, has attracted increasing interest. The possible relationship between the decrease of LncRNA-H19 and the impairment of angiogenesis in diabetes could involve impairment of the insulin-phosphatidylinositol 3-kinase (PI3K)-Akt pathway via the interdiction of LncRNA-H19...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29313393/ultrasound-mediated-nanobubble-destruction-umnd-facilitates-the-delivery-of-a10-3-2-aptamer-targeted-and-sirna-loaded-cationic-nanobubbles-for-therapy-of-prostate-cancer
#9
Meng Wu, Hongyun Zhao, Liang Guo, Yiru Wang, Jiao Song, Xueli Zhao, Chongyan Li, Lan Hao, Dong Wang, Jie Tang
The Forkhead box M1 (FoxM1) transcription factor is an important anti-tumor target. A novel targeted ultrasound (US)-sensitive nanobubble that is likely to make use of the physical energy of US exposure for the improvement of delivery efficacy to target tumors and specifically silence FoxM1 expression appears as among the most potential nanocarriers in respect of drug delivery. In this study, we synthesized a promising anti-tumor targeted FoxM1 siRNA-loaded cationic nanobubbles (CNBs) conjugated with an A10-3...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29313392/improved-intestinal-absorption-of-paclitaxel-by-mixed-micelles-self-assembled-from-vitamin-e-succinate-based-amphiphilic-polymers-and-their-transcellular-transport-mechanism-and-intracellular-trafficking-routes
#10
Xiaoyou Qu, Yang Zou, Chuyu He, Yuanhang Zhou, Yao Jin, Yunqiang Deng, Ziqi Wang, Xinru Li, Yanxia Zhou, Yan Liu
To ensure that antitumor drugs can be effectively transported across intestinal barrier and then quickly released in tumor cells, mixed polymeric micelles (Mix-PMs) were designed and fabricated by combining poly(2-ethyl-2-oxazoline)-vitamin E succinate (PEOz-VES) with TPGS1000 for enhancing intestinal absorption of paclitaxel. PEOz-VES exhibited an extremely low critical micelle concentration and negligible cytotoxicity. The Mix-PMs were characterized to have about 20 nm in diameter, uniform spherical morphology, high drug-loading content and sustained drug release profile with a retained pH-sensitivity...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29303005/bone-targeted-methotrexate-alendronate-conjugate-inhibits-osteoclastogenesis-in-vitro-and-prevents-bone-loss-and-inflammation-of-collagen-induced-arthritis-in-vivo
#11
Zi'ang Xie, Guanxiong Liu, Pan Tang, Xuewu Sun, Shuai Chen, An Qin, Peizhi Zhu, Jianfeng Zhang, Shunwu Fan
Rheumatoid arthritis (RA), a disease that causes joint destruction and bone erosion, is related to osteoclast activity. RA is generally treated with methotrexate (MTX). In this study, a MTX-Alendronate (ALN) conjugate was synthesized and characterized. The conjugate dramatically inhibited osteoclast formation and bone resorption compared with MTX and ALN used alone or in combination. Due to the characteristics of ALN, the MTX-ALN conjugate can adhere to the exposed bone surface and enhance drug accumulation in the pathological region for targeted therapy against osteoclastogenesis...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29302995/preparation-of-curcumin-self-micelle-solid-dispersion-with-enhanced-bioavailability-and-cytotoxic-activity-by-mechanochemistry
#12
Qihong Zhang, Nikolay E Polyakov, Yulia S Chistyachenko, Mikhail V Khvostov, Tatjana S Frolova, Tatjana G Tolstikova, Alexandr V Dushkin, Weike Su
An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na2GA) was prepared by mechanical ball milling. Curcumin loaded micelles were self-formed by Na2GA when SD dissolved in water. The physical properties of Cur SD in solid state were characterized by differential scanning calorimetry, X-ray diffraction studies, and scanning electron microscope. The characteristics of the sample solutions were analyzed by reverse phase HPLC, UV-visible spectroscopy, 1H NMR spectroscopy, gel permeation LC, and transmission electron microscopy...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29301434/targeted-tumor-dual-mode-ct-mr-imaging-using-multifunctional-polyethylenimine-entrapped-gold-nanoparticles-loaded-with-gadolinium
#13
Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng, Mingwu Shen, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi
We report the construction and characterization of polyethylenimine (PEI)-entrapped gold nanoparticles (AuNPs) chelated with gadolinium (Gd) ions for targeted dual mode tumor CT/MR imaging in vivo. In this work, polyethylene glycol (PEG) monomethyl ether-modified PEI was sequentially modified with Gd chelator and folic acid (FA)-linked PEG (FA-PEG) was used as a template to synthesize AuNPs, followed by Gd(III) chelation and acetylation of the remaining PEI surface amines. The formed FA-targeted PEI-entrapped AuNPs loaded with Gd (FA-Gd-Au PENPs) were well characterized in terms of structure, composition, morphology, and size distribution...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29299936/development-of-a-novel-morphological-paclitaxel-loaded-plga-microspheres-for-effective-cancer-therapy-in-vitro-and-in-vivo-evaluations
#14
Zongrui Zhang, Xinyu Wang, Binbin Li, Yuanjing Hou, Jing Yang, Li Yi
Sustained release of therapeutic agents into tumor cells is a potential approach to improve therapeutic efficacy, decrease side effects, and the drug administration frequency. Herein, we used the modified double-emulsion solvent evaporation (DSE) method to prepare a novel morphological paclitaxel (PTX) loaded poly(lactide-co-glycolide) (PLGA) microspheres (MS). The prepared rough PTX-PLGA-MS possessed microporous surface and highly porous internal structures, which significantly influenced the drug entrapment and release behaviors...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29282992/enhanced-anti-hepatocarcinoma-efficacy-by-glut1-targeting-and-cellular-microenvironment-responsive-pamam-camptothecin-conjugate
#15
Pengkai Ma, Yi Sun, Jianhua Chen, Hongpin Li, Hongyu Zhu, Xing Gao, Xinning Bi, Yujie Zhang
The efficient targeting of drugs to tumor cell and subsequent rapid drug release remain primary challenges in the development of nanomedicines for cancer therapy. Here, we constructed a glucose transporter 1 (GLUT1)-targeting and tumor cell microenvironment-sensitive drug release Glucose-PEG-PAMAM-s-s-Camptothecin-Cy7 (GPCC) conjugate to tackle the dilemma. The conjugate was characterized by a small particle size, spherical shape, and glutathione (GSH)-sensitive drug release. In vitro tumor targeting was explored in monolayer (2D) and multilayer tumor spheroid (3D) HepG2 cancer cell models (GLUT1+)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29275642/enhancement-of-dissolution-and-oral-bioavailability-of-lacidipine-via-pluronic-p123-f127-mixed-polymeric-micelles-formulation-optimization-using-central-composite-design-and-in-vivo-bioavailability-study
#16
Ahmed R Fares, Aliaa N ElMeshad, Mohamed A A Kassem
This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD) was employed to optimize the formulation variables to obtain LCDP polymeric micelles of high entrapment efficiency and small and uniform particle size (PS). Formulation variables were: Pluronic to drug ratio (A) and Pluronic P123 percentage (B). LCDP polymeric micelles were assessed for entrapment efficiency (EE%), PS and polydispersity index (PDI)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29275639/preparation-and-evaluation-of-injectable-rasagiline-mesylate-dual-controlled-drug-delivery-system-for-the-treatment-of-parkinson-s-disease
#17
Ying Jiang, Xuemei Zhang, Hongjie Mu, Hongchen Hua, Dongyu Duan, Xiuju Yan, Yiyun Wang, Qingqing Meng, Xiaoyan Lu, Aiping Wang, Wanhui Liu, Youxin Li, Kaoxiang Sun
A microsphere-gel in situ forming implant (MS-Gel ISFI) dual-controlled drug delivery system was applied to a high water-soluble small-molecule compound Rasagiline mesylate (RM) for effective treatment of Parkinson's disease. This injectable complex depot system combined an in situ phase transition gel with high drug-loading and encapsulation efficiency RM-MS prepared by a modified emulsion-phase separation method and optimized by Box-Behnken design. It was evaluated for in vitro drug release, in vivo pharmacokinetics, and in vivo pharmacodynamics...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29265887/novel-polyethyleneimine-r8-heparin-nanogel-for-high-efficiency-gene-delivery-in-vitro-and-in-vivo
#18
Linjiang Song, Xiuqi Liang, Suleixin Yang, Ning Wang, Tao He, Yan Wang, Lan Zhang, Qinjie Wu, Changyang Gong
Gene therapy is an efficient and promising approach to treat malignant tumors. However, protecting the nucleic acid from degradation in vivo and efficient delivering it into tumor cells remain challenges that require to be addressed before gene therapy could be applied in clinic. In this study, we prepared novel polyethyleneimine-RRRRRRRR(R8)-heparin (HPR) nanogel as an efficient gene delivery system, which consists of heparin and cell penetrating peptide R8 grafted low-molecule-weight polyethyleneimine (PEI)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29260912/improvement-of-chemosensitivity-and-inhibition-of-migration-via-targeting-tumor-epithelial-to-mesenchymal-transition-cells-by-adh-1-modified-liposomes
#19
Zhaoming Guo, Wenqing Li, Yue Yuan, Kun Zheng, Yu Tang, Kun Ma, Changhao Cui, Li Wang, Bing He, Qiang Zhang
How to overcome drug resistance and prevent tumor metastasis is key to the success of malignant tumor therapy. In this paper, ADH-1 peptide-modified liposomes (A-LP) have been successfully constructed for restoring chemosensitivity and suppressing cancer cell migration. With a particle size of about 90 nm, this functionalized nanocarrier was loaded with fluorescent probe or paclitaxel (PTX). Cellular uptake studies showed that A-LP facilitated the delivery of anticancer drug to tumor cells undergoing EMT...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29250984/intensive-fibrosarcoma-binding-capability-of-the-reconstituted-analog-and-its-antitumor-activity
#20
Jian Xu, Yue Du, Wen-Juan Liu, Liang Li, Yi Li, Xiao-Fei Wang, Hong-Fei Yi, Chuan-Kun Shan, Gui-Min Xia, Xiu-Jun Liu, Yong-Su Zhen
Fibrosarcomas are highly aggressive malignant tumors. It is urgently needed to explore targeted drugs and modalities for more effective therapy. Matrix metalloproteinases (MMPs) play important roles in tumor progression and metastasis, while several MMPs are highly expressed in fibrosarcomas. In addition, tissue inhibitor of metalloproteinase 2 (TIMP2) displays specific interaction with MMPs. Therefore, TIMP2 may play an active role in the development of fibrosarcoma-targeting agents. In the current study, a TIMP2-based recombinant protein LT and its enediyne-integrated analog LTE were prepared; furthermore, the fibrosarcoma-binding intensity and antitumor activity were investigated...
November 2018: Drug Delivery
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