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Drug Delivery

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https://www.readbyqxmd.com/read/28440691/n-butyl-2-cyanoacrylate-based-injectable-and-in-situ-forming-implants-for-efficient-intratumoral-chemotherapy
#1
Yanpu Wu, Luming Wang, Kaili Zhang, Lixiao Zhou, Xiaobing Zhang, Xuecheng Jiang, Chenggang Zhu
The local delivery of chemotherapeutic drugs to tumor sites is an effective approach for achieving therapeutic drug concentrations in solid tumors. Injectable implants with the ability to form in situ represent one of the most promising technologies for intratumoral chemotherapy. However, many issues must be resolved before these implants can be applied in clinical practice. Herein, we report a novel injectable in situ-forming implant system composed of n-butyl-2-cyanoacrylate (NBCA) and ethyl oleate, and the sol-gel phase transition is activated by anions in body fluids or blood...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28436718/design-of-a-novel-curcumin-soybean-phosphatidylcholine-complex-based-targeted-drug-delivery-systems
#2
Jiajiang Xie, Yanxiu Li, Liang Song, Zhou Pan, Shefang Ye, Zhenqing Hou
Recently, the global trend in the field of nanomedicine has been toward the design of combination of nature active constituents and phospholipid (PC) to form a therapeutic drug-phospholipid complex. As a particular amphiphilic molecular complex, it can be a unique bridge of traditional dosage-form and novel drug delivery system. In thisarticle, on the basis of drug-phospholipid complex technique and self-assembly technique, we chose a pharmacologically safe and low toxic drug curcumin (CUR) to increase drug-loading ability, achieve controlled/sustained drug release and improve anticancer activity...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28436702/a-novel-matrix-dispersion-based-on-phospholipid-complex-for-improving-oral-bioavailability-of-baicalein-preparation-in-vitro-and-in-vivo-evaluations
#3
Yang Zhou, Wujun Dong, Jun Ye, Huazhen Hao, Junzhuo Zhou, Renyun Wang, Yuling Liu
Phospholipid complex is one of the most successful approaches for enhancing oral bioavailability of poorly absorbed plant constituents. But the sticky property of phospholipids results in an unsatisfactory dissolution of drugs. In this study, a matrix dispersion of baicalein based on phospholipid complex (BaPC-MD) was first prepared by a discontinuous solvent evaporation method, in which polyvinylpyrrolidone-K30 (PVP-K30) was employed for improving the dispersibility of baicalein phospholipid complex (BaPC) and increasing dissolution of baicalein...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28426265/transdermal-iontophoresis-patch-with-reverse-electrodialysis
#4
Joon Lee, Kilsung Kwon, Minyoung Kim, Joonhong Min, Nathaniel S Hwang, Won-Serk Kim
Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy. The current density, which can be controlled easily without special circuit, is enough to iontophoretic drug delivery. In vitro study, this iontophoretic system enhanced the transdermal delivery of peptide, which is difficult to penetrate the skin barrier by simple diffusion. We design the disposable iontophoretic skin patch using RED system and suggest this patch can be apply on new cosmetic patch or disposable drug patch...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28415883/electrosteric-stealth-rivastigmine-loaded-liposomes-for-brain-targeting-preparation-characterization-ex-vivo-bio-distribution-and-in-vivo-pharmacokinetic-studies
#5
Sara Nageeb El-Helaly, Ahmed Abd Elbary, Mohamed A Kassem, Mohamed A El-Nabarawi
Being one of the highly effective drugs in treatment of Alzheimer's disease, Rivastigmine brain targeting is highly demandable, therefore liposomal dispersion of Rivastigmine was prepared containing 2 mol% PEG-DSPE added to Lecithin, Didecyldimethyl ammonium bromide (DDAB), Tween 80 in 1:0.02:0.25 molar ratio. A major challenge during the preparation of liposomes is maintaining a stable formulation, therefore the aim of our study was to increase liposomal stability by addition of DDAB to give an electrostatic stability and PEG-DSPE to increase stability by steric hindrance, yielding what we called an electrosteric stealth (ESS) liposomes...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28414557/polydopamine-and-peptide-decorated-doxorubicin-loaded-mesoporous-silica-nanoparticles-as-a-targeted-drug-delivery-system-for-bladder-cancer-therapy
#6
Yi Wei, Li Gao, Lu Wang, Lin Shi, Erdong Wei, Baotong Zhou, Li Zhou, Bo Ge
We reported a simple polydopamine (PDA)-based surface modification method to prepare novel targeted doxorubicin-loaded mesoporous silica nanoparticles and peptide CSNRDARRC conjugation (DOX-loaded MSNs@PDA-PEP) for enhancing the therapeutic effects on bladder cancer. Drug-loaded NPs were characterized in terms of size, size distribution, zeta potential, transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) surface area and drug loading content. In vitro drug release indicated that DOX-loaded MSNs@PDA and MSNs@PDA-PEP had similar release kinetic profiles of DOX...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28368209/enhanced-cytotoxic-effect-of-camptothecin-nanosponges-in-anaplastic-thyroid-cancer-cells-in-vitro-and-in-vivo-on-orthotopic-xenograft-tumors
#7
Casimiro Luca Gigliotti, Benedetta Ferrara, Sergio Occhipinti, Elena Boggio, Giuseppina Barrera, Stefania Pizzimenti, Mirella Giovarelli, Roberto Fantozzi, Annalisa Chiocchetti, Monica Argenziano, Nausicaa Clemente, Francesco Trotta, Caterina Marchiò, Laura Annaratone, Renzo Boldorini, Umberto Dianzani, Roberta Cavalli, Chiara Dianzani
Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel formulations for drug delivery. Nanomedicine has enormous potential to improve the accuracy of cancer therapy by enhancing availability and stability, decreasing effective doses and reducing side effects of drugs. Camptothecin (CPT) is an inhibitor of DNA topoisomerase-I with several anticancer properties but has poor solubility and a high degradation rate...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28368206/honokiol-loaded-polymeric-nanoparticles-an-active-targeting-drug-delivery-system-for-the-treatment-of-nasopharyngeal-carcinoma
#8
Bo Yang, XiaoLing Ni, LongXia Chen, Heng Zhang, PeiRong Ren, Yue Feng, Yue Chen, ShaoZhi Fu, JingBo Wu
The purpose of this study was to develop a novel drug delivery system for a sustained and targeted delivery of honokiol (HK) to the nasopharyngeal carcinoma (NPC) HNE-1 cell lines, since the folate receptor (FR) is over-expressed on their surface. Emulsion solvent evaporation was used to develop the active targeting nanoparticles-loaded HK (ATNH) using copolymerpoly (ɛ-caprolactone)-poly (ethyleneglycol)-poly (ɛ-caprolactone) (PCEC), which was modified with folate (FA) by introducing Polythylenimine (PEI)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28283003/bacterial-magnetic-particles-improve-testes-mediated-transgene-efficiency-in-mice
#9
COMPARATIVE STUDY
Chao Wang, Guanghong Sun, Ye Wang, Nana Kong, Yafei Chi, Leilei Yang, Qiliang Xin, Zhen Teng, Xu Wang, Yujun Wen, Ying Li, Guoliang Xia
Nano-scaled materials have been proved to be ideal DNA carriers for transgene. Bacterial magnetic particles (BMPs) help to reduce the toxicity of polyethylenimine (PEI), an efficient gene-transferring agent, and assist tissue transgene ex vivo. Here, the effectiveness of the BMP-PEI complex-conjugated foreign DNAs (BPDs) in promoting testes-mediated gene transfer (TMGT) in mouse was compared with that of liposome-conjugated foreign DNAs. The results proved that through testes injection, the clusters of BPDs successfully reached the cytoplasm and the nuclear of spermatogenesis cell, and expressed in testes of transgene founder mice...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28283000/characterization-and-evaluation-of-a-self-microemulsifying-drug-delivery-system-containing-tectorigenin-an-isoflavone-with-low-aqueous-solubility-and-poor-permeability
#10
Yunrong Zhang, Li He, Shanlan Yue, Qingting Huang, Yuhong Zhang, Junyi Yang
The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility. The microemulsion formed by TG-SMEDDS was globular, edge smooth, clear-cut, and distribution homogeneous under transmission electron microscope. The stability studies revealed that TG-SMEDDS remained stable at room temperature for at least 3 months...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28282993/thermosensitive-porphyrin-incorporated-hydrogel-with-four-arm-peg-pcl-copolymer-ii-doxorubicin-loaded-hydrogel-as-a-dual-fluorescent-drug-delivery-system-for-simultaneous-imaging-tracking-in-vivo
#11
Xia Dong, Hongli Chen, Jingwen Qin, Chang Wei, Jie Liang, Tianjun Liu, Deling Kong, Feng Lv
Visualization of a drug delivery system could reveal the pharmacokinetic properties, which is essential for the design of a novel drug delivery system. In vivo optical imaging offers an advanced tool to monitor the drug release process and the therapeutic effect by the combination of fluorescence imaging and bioluminescence imaging. Multispectral fluorescence imaging can separate the drug and the carrier without interference. Herein, a dual fluorescent anti-tumor drug delivery system was monitored with the doxorubicin-loaded hydrogel to further explore the application of the porphyrin-incorporated hydrogel with four-arm PEG-PCL copolymer as a drug carrier, based on the beneficial fluorescence and good biocompatibility of the porphyrin incorporated hydrogel...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28282989/sustained-release-ivermectin-loaded-solid-lipid-dispersion-for-subcutaneous-delivery-in-vitro-and-in-vivo-evaluation
#12
Mengmeng Lu, Dan Xiong, Weiwei Sun, Tong Yu, Zixia Hu, Jiafeng Ding, Yunpeng Cai, Shizhuang Yang, Baoliang Pan
This work aimed to develop a sustained release solid dispersion of ivermectin (IVM-SD) in a lipid matrix (hydrogenated castor oil, HCO) for subcutaneous delivery. Solvent-melting technology was employed to prepare IVM-SDs using HCO. The physicochemical properties of the IVM-SDs were evaluated by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), and Fourier transform infrared spectroscopy (FTIR). The release of IVM from IVM-SDs was evaluated with HPLC in vitro. Pharmacokinetics of IVM was studied in rabbits following a single subcutaneous administration of IVM-SD formulations...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28240047/antitumor-activity-of-intratracheal-inhalation-of-temozolomide-tmz-loaded-into-gold-nanoparticles-and-or-liposomes-against-urethane-induced-lung-cancer-in-balb-c-mice
#13
Mohamed A Hamzawy, Amira M Abo-Youssef, Heba F Salem, Sameh A Mohammed
The current study aimed to develop gold nanoparticles (GNPs) and liposome-embedded gold nanoparticles (LGNPs) as drug carriers for temozolomide (TMZ) and investigate the possible therapeutic effects of intratracheal inhalation of nanoformulation of TMZ-loaded gold nanoparticles (TGNPs) and liposome-embedded TGNPs (LTGNPs) against urethane-induced lung cancer in BALB/c mice. Physicochemical characters and zeta potential studies for gold nanoparticles (GNPs) and liposome-embedded gold nanoparticles (LGNPs) were performed...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28240046/-fusion-and-binding-inhibition-key-target-for-hiv-1-treatment-and-pre-exposure-prophylaxis-targets-drug-delivery-and-nanotechnology-approaches
#14
REVIEW
Tanushree Malik, Gaurav Chauhan, Goutam Rath, R S R Murthy, Amit K Goyal
More than 35 million people are living with HIV worldwide with approximately 2.3 million new infections per year. Cascade of events (cell entry, virus replication, assembly and release of newly formed virions) is involved in the HIV-1 transmission process. Every single step offers a potential therapeutic strategy to halt this progression and HIV fusion into the human host cell is one such stage. Controlling the initial event of HIV-1 transmission is the best way to control its dissemination especially when prophylaxis is concerned...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28222611/influence-of-peg-coating-on-the-oral-bioavailability-of-gold-nanoparticles-in-rats
#15
Ahmed Alalaiwe, Georgia Roberts, Paul Carpinone, John Munson, Stephen Roberts
Metallic nanoparticles can be produced in a variety of shapes, sizes, and surface chemistries, making them promising potential tools for drug delivery. Most studies to date have evaluated uptake of metallic nanoparticles from the GI tract with methods that are at best semi-quantitative. This study used the classical method of comparing blood concentration area under the curve (AUC) following intravenous and oral doses to determine the oral bioavailability of 1, 2 and 5 kDa PEG-coated 5 nm gold nanoparticles (AuNPs)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28219253/in-vitro-and-in-vivo-evaluation-of-macromolecular-prodrug-gc-fua-based-nanoparticle-for-hepatocellular-carcinoma-chemotherapy
#16
Can Huang, Na-Mei Li, Pei Gao, Sa Yang, Qian Ning, Wen Huang, Zhi-Ping Li, Peng-Ju Ye, Li Xiang, Dong-Xiu He, Xiang-Wen Tan, Cui-Yun Yu
A novel type of macromolecular prodrug delivery system is reported in this research. The N-galactosylated-chitosan-5-fluorouracil acetic acid conjugate (GC-FUA) based nanoparticle delivery system was evaluated in vitro and in vivo. Biocompatibility of GC-FUA-NPs was screened by BSA adsorption test and hemolysis activity examination in vitro. Cytotoxicity and cellular uptake study in HepG2 and A549 cells demonstrated that compared to free 5-Fu, the GC-FUA-NPs play great function in killing cancer cells for the cell endocytosis mediated by asialoglycoprotein receptor (ASGPR), which overexpresses on the cell surface...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28195032/ph-responsive-carriers-for-oral-drug-delivery-challenges-and-opportunities-of-current-platforms
#17
REVIEW
Lin Liu, WenDong Yao, YueFeng Rao, XiaoYang Lu, JianQing Gao
Oral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal epithelium in the gastrointestinal (GI) tract. pH-Responsive carriers offer excellent potential as oral therapeutic systems due to enhancing the stability of drug delivery in stomach and achieving controlled release in intestines...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28181841/surface-density-of-polyarginine-influence-the-size-zeta-potential-cellular-uptake-and-tissue-distribution-of-the-nanostructured-lipid-carrier
#18
COMPARATIVE STUDY
Mingshuang Sun, Zhihong Zhu, Huixin Wang, Cuiyan Han, Dandan Liu, Lei Tian, Xinggang Yang, Weisan Pan
Poly-arginines are strong tools to elevate the cellular uptake of nanopreparations. To learn the influence of poly-arginine (RRRRRRRR, R8) density on a series of properties of nanostructured lipid carrier (NLC), we build six R8 modified NLCs with different R8 densities (nR-NLC, where n represents the R8 ratio) by fusion-emulsion method with the aid of stearyl-R8. The pharmaceutical characteristics like size, zeta potential and in vitro drug release, cellular uptake, cytotoxicity to A549 cells and tissue distribution in S180 tumor-bearing mice of the six nR-NLCs are all investigated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28181840/transdermal-delivery-of-isoniazid-and-rifampin-in-guinea-pigs-by-electro-phonophoresis
#19
COMPARATIVE STUDY
Suting Chen, Yi Han, Daping Yu, Fengmin Huo, Fen Wang, Yunxu Li, Lingling Dong, Zhidong Liu, Hairong Huang
Electro-phonophoresis (EP) has been used as a drug delivery approach in clinical fields. The objective of the present study is to evaluate the skin permeability of isoniazid and rifampin in guinea pigs by EP to provide reference basis for clinical applications of such transdermal delivery system in the treatment of patients with superficial tuberculosis. Isoniazid and rifampin solutions were delivered transdermally with or without EP in health guinea pigs for 0.5 h. Local skin and blood samples were collected serially at 0, 1/2, 1, 2, 4, 6 and 24 h after dosing...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28181839/anhydrous-reverse-micelle-nanoparticles-new-strategy-to-overcome-sedimentation-instability-of-peptide-containing-pressurized-metered-dose-inhalers
#20
Zhengwei Huang, Han Wu, Beibei Yang, Longkai Chen, Ying Huang, Guilan Quan, Chune Zhu, Xing Li, Xin Pan, Chuanbin Wu
The objective of this study was to develop a novel anhydrous reverse micelle nanoparticles (ARM-NPs) system to overcome the sedimentation instability of peptide-containing pressurized metered-dose inhalers (pMDIs). A bottom-up method was utilized to fabricate ARM-NPs. Tertiary butyl alcohol (TBA)/water system, freeze-drying and lipid inversion method were successively used to produce the ARM-NPs for pMDI. Various characteristics of ARM-NPs were investigated including particle size, morphology, secondary structure of the peptide drug, aerosolization properties and storage stability...
November 2017: Drug Delivery
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