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Drug Delivery

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https://www.readbyqxmd.com/read/29069936/correction-to-dong-et%C3%A2-al-promising-galactose-decorated-biodegradable-poloxamer-188-plga-diblock-copolymer-nanoparticles-of-resibufogenin-for-enhancing-liver-cancer-therapy
#1
(no author information available yet)
No abstract text is available yet for this article.
October 25, 2017: Drug Delivery
https://www.readbyqxmd.com/read/28956465/correction-to-mei-et%C3%A2-al-an-injectable-in-situ-gel-with-cubic-hexagonal-nanostructures-for-local-treatment-of-chronic-periodontitis
#2
(no author information available yet)
No abstract text is available yet for this article.
September 28, 2017: Drug Delivery
https://www.readbyqxmd.com/read/29069996/transporting-carriers-for-intracellular-targeting-delivery-via-non-endocytic-uptake-pathways
#3
Zuhong Li, Yanhong Zhang, Danhua Zhu, Shuiqing Li, Xiaopeng Yu, Yalei Zhao, Xiaoxi Ouyang, Zhongyang Xie, Lanjuan Li
To develop novel therapies for clinical treatments, it increasingly depends on sophisticated delivery systems that facilitate the drugs entry into targeting cells. Profound understanding of cellular uptake routes for transporting carriers promotes the optimization of performance in drug delivery systems. Although endocytic pathway is the most important part of cellular uptake routes for many delivery systems, it suffers the trouble of enzymatic degradation of transporting carriers trapped in endosomes/lysosomes...
December 2017: Drug Delivery
https://www.readbyqxmd.com/read/29069944/photosensitive-drugs-a-review-on-their-photoprotection-by-liposomes-and-cyclodextrins
#4
Giuseppina Ioele, Michele De Luca, Antonio Garofalo, Gaetano Ragno
Nowadays, an exciting challenge in the drug chemistry and technology research is represented by the development of methods aimed to protect molecular integrity and therapeutic activity of drugs from effects of light. The photostability characterization is ruled by ICH (The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use), which releases details throughout basic protocols of stability tests to be performed on new medicinal products for human use. The definition of suitable photoprotective systems is fundamental for pharmaceutical manufacturing and for human healthy as well, since light exposure may affect either drugs or drug formulations giving rise even to allergenic or mutagenic by-products...
December 2017: Drug Delivery
https://www.readbyqxmd.com/read/29069934/biological-responses-to-nanomaterials-understanding-nano-bio-effects-on-cell-behaviors
#5
Xi-Qiu Liu, Rui-Zhi Tang
The unique properties of nanomaterials in drug delivery and tissue engineering have captured a great deal of attention as experimental tools in bioimaging, diagnostic, and therapeutic processes. A plenty of research have provided a strong evidence that nanostructures not only passively interact with cells but also actively engage and mediate cell functions and molecular processes. Undoubtedly, it is crucially important to better understand biological responses to engineered nanomaterials, especially in view of their potential for biomedical applications...
December 2017: Drug Delivery
https://www.readbyqxmd.com/read/29069931/synthetic-lipoprotein-as-nano-material-vehicle-in-the-targeted-drug-delivery
#6
Xueqin Zhang, Gangliang Huang
High-density lipoprotein (HDL) and low-density lipoprotein (LDL), as human endogenous lipoprotein particles, have low toxicity, high selectivity, and good safety. They can avoid the recognition and clearance of human reticuloendothelial system. These synthetic lipoproteins (sLPs) have been attracted extensive attention as the nanovectors for tumor-targeted drug and gene delivery. Herein, recent advances in the field of anticancer based on these two lipid proteins and recombinant lipoproteins (rLPs) as target delivery vectors were analyzed and discussed...
December 2017: Drug Delivery
https://www.readbyqxmd.com/read/29069920/cleavable-pegylation-a-strategy-for-overcoming-the-peg-dilemma-in-efficient-drug-delivery
#7
Yan Fang, Jianxiu Xue, Shan Gao, Anqi Lu, Dongjuan Yang, Hong Jiang, Yang He, Kai Shi
To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape. As a result, the activity of drugs is inevitably lost after PEG modification. To achieve successful drug delivery for effective treatment, the crucial issue associated with the use of PEG-lipids, that is, "PEG dilemma" must be addressed...
December 2017: Drug Delivery
https://www.readbyqxmd.com/read/29141461/development-of-magnetic-anionic-liposome-atelocollagen-complexes-for-efficient-magnetic-drug-targeting
#8
Yusuke Kono, Taketo Nakai, Hitomi Taguchi, Takuya Fujita
Magnetic nanoparticle-incorporated liposomes (magnetic liposomes) are considered a promising site-specific drug delivery carrier vehicle. With regard to their surface charge, magnetic anionic liposomes (Mag-AL) demonstrate little toxicity in comparison with magnetic cationic liposomes (Mag-CL), whereas their cellular association and uptake efficiency are low. In the current study, we constructed complexes of Mag-AL and atelocollagen (ATCOL), which is a biocompatible and minimally immunogenic biomaterial, to improve the cellular uptake properties of Mag-AL in vitro and in vivo...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29124978/sustained-release-solid-dispersion-of-pelubiprofen-using-the-blended-mixture-of-aminoclay-and-ph-independent-polymers-preparation-and-in-vitro-in-vivo-characterization
#9
Yeo-Song Lee, Jae Guen Song, Sang Hoon Lee, Hyo-Kyung Han
The present study aimed to develop the sustained-release oral dosage form of pelubiprofen (PEL) by using the blended mixture of 3-aminopropyl functionalized-magnesium phyllosilicate (aminoclay) and pH-independent polymers. The sustained-release solid dispersion (SRSD) was prepared by the solvent evaporation method and the optimal composition of SRSD was determined as the weight ratio of drug: Eudragit® RL PO: Eudragit® RS PO of 1:1:2 in the presence of 1% of aminoclay (SRSD(F6)). The dissolution profiles of SRSD(F6) were examined at different pHs and in the simulated intestinal fluids...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29119846/carbonate-apatite-nanoparticles-carry-sirna-s-targeting-growth-factor-receptor-genes-egfr1-and-erbb2-to-regress-mouse-breast-tumor
#10
Snigdha Tiash, Nur Izyani Binti Kamaruzman, Ezharul Hoque Chowdhury
Cancer cells lose their control on cell cycle by numerous genetic and epigenetic alterations. In a tumor, these cells highly express growth factor receptors (GFRs), eliciting growth, and cell division. Among the GFRs, epidermal growth factor receptor-1 (EGFR1) (Her1/ERBB1) and epidermal growth factor receptor-2 (EGFR2) (Her2/ERBB2) from epidermal growth factor (EGF) family and insulin-like growth factor-1 receptor (IGF1R) are highly expressed on breast cancer cells, thus contributing to the aggressive growth and invasiveness, have been focused in this study...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29115900/preparation-characterization-and-antitumor-activity-evaluation-of-apigenin-nanoparticles-by-the-liquid-antisolvent-precipitation-technique
#11
Weiwei Wu, Yuangang Zu, Li Wang, Lingling Wang, Huimei Wang, Yuanyuan Li, Mingfang Wu, Xiuhua Zhao, Yujie Fu
The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-Expert(®) software. Under the optimum conditions, the particle size of the apigenin nanosuspension was about 159.2 nm. In order to get apigenin nanoparticles, the freeze-drying method was selected and the mannitol was used as a cryoprotectant...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29115885/a-novel-lipid-prodrug-strategy-for-sustained-delivery-of-hexadecyloxypropyl-9-2-phosphonomethoxy-ethyl-guanine-hdp-pmeg-on-unwanted-ocular-proliferation
#12
Mei Chen, Jiangping Hou, Guilin Tan, Peng Xie, William R Freeman, James R Beadle, Karl Y Hostetler, Lingyun Cheng
Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty comes from lack of potent antiproliferative agent and lack of sustained delivery to cover high-risk time window for PVR to develop. Lipid prodrug of PMEG, hexadecyloxypropyl 9-[(2-phosphonomethoxy)ethyl]guanine (HDP-PMEG), was prepared and was evaluated as a pharmacological adjuvant to surgical management of PVR. A dose-escalation study determined that the highest nontoxic dose for intravitreal use in pigmented rabbits was 3 µg per eye...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29098877/hydrophobic-binding-peptide-conjugated-hybrid-lipid-mesoporous-silica-nanoparticles-for-effective-chemo-photothermal-therapy-of-pancreatic-cancer
#13
Raj Kumar Thapa, Hanh Thuy Nguyen, Milan Gautam, Aarajana Shrestha, Eung Seok Lee, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Nanoparticle-based drug delivery systems are designed to reach tumor sites based on their enhanced permeation and retention effects. However, a lack of interaction of these nanoparticles with cancer cells might lead to reduced uptake in the tumors, which might compromise the therapeutic efficacy of the system. Therefore, we developed bortezomib and IR-820-loaded hybrid-lipid mesoporous silica nanoparticles conjugated with the hydrophobic-binding peptide, cyclosporine A (CsA), and referred to them as CLMSN/BIR...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29092646/synergistic-dual-modified-liposome-improves-targeting-and-therapeutic-efficacy-of-bone-metastasis-from-breast-cancer
#14
Xianzhu Ke, Wen Lin, Xiaokang Li, Hailiang Wang, Xin Xiao, Zheng Guo
Breast cancer frequently metastasizes to bone, where it leads to poor clinical prognosis. Due to the peculiarity of the bone microstructure, the uptake of drugs often happens at non-targeted sites, which produces a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both an octapeptide with eight repeating sequences of aspartate (Asp8) and folate to create a more selective and efficient drug delivery system to target cancer cells in bone tissue...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29078721/the-role-of-osmolarity-adjusting-agents-in-the-regulation-of-encapsulated-cell-behavior-to-provide-a-safer-and-more-predictable-delivery-of-therapeutics
#15
Ainhoa Gonzalez-Pujana, Aitor Rementeria, Francisco Javier Blanco, Manoli Igartua, Jose Luis Pedraz, Edorta Santos-Vizcaino, Rosa Maria Hernandez
Transplantation of cells within alginate microspheres has been extensively studied for sustained drug delivery. However, the lack of control over cell behavior represents a major concern regarding the efficacy and the safety of the therapy. Here, we demonstrated that when formulating the biosystem, an adequate selection of osmolarity adjusting agents significantly contributes to the regulation of cell responses. Our data showed that these agents interact in the capsule formation process, influencing the alginate crosslinking degree...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29078713/characterization-of-brusatol-self-microemulsifying-drug-delivery-system-and-its-therapeutic-effect-against-dextran-sodium-sulfate-induced-ulcerative-colitis-in-mice
#16
Jiangtao Zhou, Lihua Tan, Jianhui Xie, Zhengquan Lai, Yanfeng Huang, Chang Qu, Dandan Luo, Zhixiu Lin, Ping Huang, Ziren Su, Youliang Xie
Brusatol (BR) is one of the main bioactive components derived from Brucea javanica, a medicinal herb historically used in the treatment of dysenteric disorders (also known as ulcerative colitis(UC)). Due to its poor aqueous solubility, a novel brusatol self-microemulsifying drug delivery system (BR-SMEDDS) nanoformulation with smaller size, higher negative zeta potential and drug content, and excellent stability was developed. The appearance of BR-SMEDDS remained clear and transparent, and transmission electron microscopy showed microemulsion droplets to be spherical with homogeneous distribution...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29069980/immunotherapeutic-effect-of-bcg-polysaccharide-nucleic-acid-powder-on-mycobacterium-tuberculosis-infected-mice-using-microneedle-patches
#17
Qinying Yan, Houming Liu, Zhigang Cheng, Yun Xue, Zhide Cheng, Xuyong Dai, Wanshui Shan, Fan Chen
Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunotherapeutic effects exist. Here, BCG-PSN powder was applied directly to the skin to evaluate the immunotherapeutic effects on mice infected with Mycobacterium tuberculosis (MTB). In total, 34 μg of BCG-PSN powder could be loaded into a microneedle patch (MNP)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29063815/n-acetyl-l-cysteine-functionalized-nanostructured-lipid-carrier-for-improving-oral-bioavailability-of-curcumin-preparation-in-vitro-and-in-vivo-evaluations
#18
Cihui Tian, Sajid Asghar, Yifan Wu, Daddy Kambere Amerigos, Zhipeng Chen, Mei Zhang, Lining Yin, Lin Huang, Qineng Ping, Yanyu Xiao
The application of orally administered nanoparticles in the circulation system is limited by the secretion and shedding of intestinal tract mucous layer. In order to enhance mucoadhesion and mucus penetration of curcumin (Cur)-loaded nanostructured lipid carrier (NLC) after oral administration, a new multifunctional conjugate, N-acetyl-L-cysteine-polyethylene glycol (100)-monostearate (NAPG), was synthesized. Functionalized nanocarriers (Cur-NAPG-NLC) modified by different amounts of NAPG (the amounts of NAPG were 20, 50, and 100 mg) were prepared and investigated for in vitro and in vivo behavior...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29063794/critical-physicochemical-and-biological-attributes-of-nanoemulsions-for-pulmonary-delivery-of-rifampicin-by-nebulization-technique-in-tuberculosis-treatment
#19
Kifayatullah Shah, Lai Wah Chan, Tin Wui Wong
The study investigated aerosolization, pulmonary inhalation, intracellular trafficking potential in macrophages and pharmacokinetics profiles of rifampicin-oleic acid first-generation nanoemulsion and its respective chitosan- and chitosan-folate conjugate-decorated second and third-generation nanoemulsions, delivered via nebulization technique. The nanoemulsions were prepared by conjugate synthesis and spontaneous emulsification techniques. They were subjected to physicochemical, drug release, aerosolization, inhalation, cell culture and pharmacokinetics analysis...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29063791/ginsenoside-rg3-micelles-mitigate-doxorubicin-induced-cardiotoxicity-and-enhance-its-anticancer-efficacy
#20
Lan Li, Jingyu Ni, Min Li, Jingrui Chen, Lifeng Han, Yan Zhu, Deling Kong, Jingyuan Mao, Yi Wang, Boli Zhang, Meifeng Zhu, Xiumei Gao, Guanwei Fan
Doxorubicin (DOX) is one of the most effective chemotherapy agents used in the treatment of hematological and solid tumors, however, it causes dose-related cardiotoxicity that may lead to heart failure in patients. One of the major reasons was increased reactive oxygen species (ROS) production. Ginsenoside Rg3 (Rg3), was powerful free radical scavengers and possessed cardioprotective effects. Nevertheless, Rg3 has low aqueous solubility and oral bioavailability, limiting its effects. Herein, we encapsulated Rg3 through spontaneous self-assembly of Pluronic F127 to improve its solubility and oral bioavailability...
November 2017: Drug Delivery
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