Acácio S de Souza, Deborah S Dias, Ruan C B Ribeiro, Dora C S Costa, Matheus G de Moraes, David R Pinho, Maria E G Masset, Laís M Marins, Sandy P Valle, Cláudio J C de Carvalho, Gustavo S G de Carvalho, Angélica Lauria N Mello, Mauro Sola-Penna, Marcos V Palmeira-Mello, Raissa A Conceição, Carlos R Rodrigues, Alessandra M T Souza, Luana da S M Forezi, Patricia Zancan, Vitor F Ferreira, Fernando de C da Silva
The search for novel anticancer drugs is essential to expand treatment options, overcome drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The importance of these studies lies in their contribution to advancing cancer research and enhancing patient outcomes in the battle against cancer. Here, we developed new asymmetric hybrids containing two different naphthoquinones linked by a 1,2,3-1H-triazole nucleus, which are potential new drugs for cancer treatment. The antitumor activity of the novel compounds was tested using the breast cancer cell lines MCF-7 and MDA-MB-231, using the non-cancer cell line MCF10A as control...
March 5, 2024: Bioorganic & Medicinal Chemistry