journal
MENU ▼
Read by QxMD icon Read
search

European Journal of Pharmaceutical Sciences

journal
https://www.readbyqxmd.com/read/27919703/prediction-and-mechanism-elucidation-of-analyte-retention-on-phospholipid-stationary-phases-iam-hplc-by-in-silico-calculated-physico-chemical-descriptors
#1
Giacomo Russo, Lucia Grumetto, Francesco Barbato, Giulio Vistoli, Alessandro Pedretti
The present study proposes a method for an in silico calculation of phospholipophilicity. Phospholipophilicity is intended as the measure of analyte affinity for phospholipids; it is currently assessed by HPLC measures of analyte retention on phosphatidylcholine-like stationary phases (IAM - Immobilized Artificial Membrane) resulting in log kW(IAM) values. Due to the amphipathic and electrically charged nature of phospholipids, retention on these stationary phases results from complex mechanisms, being affected not only by lipophilicity (as measured by n-octanol/aqueous phase partition coefficients, log P) but also by the occurrence of polar and/or electrostatic intermolecular interaction forces...
December 2, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27919702/design-of-pvp-va-s-630-based-tadalafil-solid-dispersion-to-enhance-the-dissolution-rate
#2
Jin-Seok Choi, Jeong-Sook Park
Tadalafil (TDF) is a Biopharmaceutics Classification System (BCS) class II drug; the efficacy thereof is critically limited by inherent poor water solubility. Solid dispersion (SD) techniques are widely used to improve the bioavailability of drugs that are poorly water-soluble. Herein, we used an SD technique to improve the solubility and in vitro dissolution rate of TDF; a solvent evaporation method was applied involving the use of hydrophilic carriers (PVP/VA S-630) and assistants (malic acid or meglumine)...
December 2, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27916697/composition-dependent-structural-changes-and-antitumor-activity-of-asc-dp-dspe-peg-nanoparticles
#3
Kenjirou Higashi, Fusako Mibu, Kengo Saito, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe
Ascorbyl 2,6-dipalmitate (ASC-DP) and distearoyl phosphatidylethanolamine polyethylene glycol 2000 (DSPE-PEG) formed stable nanoparticles at a molar ratio of less than or equal to 2:1 after dispersing the solvent-evaporated film in water. The mean particle sizes measured by dynamic light scattering were within the range of ca. 100-160nm. Composition-dependent changes of the ASC-DP and DSPE-PEG molecular states within the film were analyzed by wide-angle X-ray diffraction and infrared (IR) and solid-state nuclear magnetic resonance (NMR) spectroscopy...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27916696/molecular-mobility-in-the-supercooled-and-glassy-states-of-nizatidine-and-perphenazine
#4
U Sailaja, M ShahinThayyil, N S Krishna Kumar, G Govindaraj, K L Ngai
The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27916695/the-advantage-of-hollow-mesoporous-carbon-as-a-near-infrared-absorbing-drug-carrier-in-chemo-photothermal-therapy-compared-with-ir-820
#5
Qinfu Zhao, Xiudan Wang, Yue Yan, Da Wang, Ying Zhang, Tongying Jiang, Siling Wang
In this study, we synthesized a kind of hollow mesoporous carbon (HMC) as near-infrared (NIR) nanomaterial and made a comparison between HMC and IR-820 commercially available in terms of heat generation properties and thermal stability exposed under NIR laser irradiation. The NIR-induced photothermal tests indicated that HMC had excellent heat generating capacity and remained stable after exposed to NIR laser irradiation for several times. On the contrary, the IR-820 was thermal unstable and degraded completely after exposed to NIR laser irradiation for only one time...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27916694/regenerated-cellulose-capsules-for-controlled-drug-delivery-part-iv-in-vitro-evaluation-of-novel-self-pore-forming-regenerated-cellulose-capsules
#6
Bhavik Bhatt, Vijay Kumar
In the present work, the release mechanisms of active pharmaceutical ingredients (APIs) enclosed in self-pore forming regenerated cellulose (RC) two-piece hard shell capsules are described. The RC capsules were fabricated using a modified dip-coating approach, which yielded an assembled dosage form that was equivalent in size and shape to a conventional gelatin two-piece hard shell capsule. Drug release characteristics from RC capsules were evaluated using potassium chloride, diphenhydramine hydrochloride, tramadol hydrochloride, niacinamide, acetaminophen and ketoprofen as model APIs...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27916693/comparison-of-2-strategies-to-enhance-pyridoclax-solubility-nanoemulsion-delivery-system-versus-salt-synthesis
#7
A-C Groo, M De Pascale, A-S Voisin-Chiret, S Corvaisier, M Since, A Malzert-Fréon
Pyridoclax is an original oligopyridine lead, very promising in treatment of chemoresistant cancers. However, from solubility measurement and permeability evaluation, it appeared that this compound can be considered as a BCS II drug, with a poor water solubility. To overcome this unfavorable property, two strategies were proposed and compared: pyridoclax di-hydrochloride salt synthesis and formulation of pyridoclax-loaded nanoemulsions (PNEs) efficiently performed by transposing the spontaneous emulsification process previously developed by our team...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27908675/effect-of-polymers-in-moisture-sorption-and-physical-stability-of-polymorphic-olanzapine
#8
Maria C Paisana, Martin A Wahl, F João
The study aims to elucidate the transformations of anhydrous olanzapine Form I (OLZ FI) into the hydrate forms, when stored at a high relative humidity or suspended in an aqueous media, in the presence of polymers. OLZ FI and physical mixtures (3:1 and 1:1, as powders or compacts) of olanzapine with polyethylene glycol (PEG-6000), polyvinylpyrrolidone (PVP K25) and hydroxypropylcellulose (HPC-LF) were stored (75%RH/25°C, 75%RH/40°C and 93%RH/25°C) for 28days. OLZ FI and the physical mixtures were also suspended in water under stirring (200rpm/60min)...
November 28, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27890698/clementine-juice-has-the-potential-for-drug-interactions-in-vitro-comparison-with-grapefruit-and-mandarin-juice
#9
Dirk Theile, Nicolas Hohmann, Dominik Kiemel, Giuseppe Gattuso, Davide Barreca, Gerd Mikus, Walter Emil Haefeli, Vedat Schwenger, Johanna Weiss
Adverse drug interactions due to grapefruit juice are well known prompting warnings even in drug labels. Similar issues have not been reported for clementines and available data is scarce, despite of genetic descent. We observed substantially increased tacrolimus trough concentrations in a renal transplant patient consuming high clementine amounts and, thus, scrutinised the effects of clementine juice on drug metabolism and drug transporters in vitro and compared it to the effects of mandarin and grapefruit juice...
November 24, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27890596/monoacyl-phosphatidylcholine-inhibits-the-formation-of-lipid-multilamellar-structures-during-in-vitro-lipolysis-of-self-emulsifying-drug-delivery-systems
#10
Thuy Tran, Scheyla D V S Siqueira, Heinz Amenitsch, Thomas Rades, Anette Müllertz
The colloidal structures formed during lipolysis of self-emulsifying drug delivery systems (SEDDS) might affect the solubilisation and possibly the absorption of drugs. The aim of the current study is to elucidate the structures formed during the in vitro lipolysis of four SEDDS containing medium-chain glycerides and caprylocaproyl polyoxyl-8 glycerides (Labrasol), with or without monoacyl phosphatidylcholine (MAPC). In situ synchrotron small-angle X-ray scattering (SAXS) was combined with ex situ cryogenic transmission electron microscopy (cryo-TEM) and dynamic light scattering (DLS) to elucidate the generated structures...
November 24, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27890595/the-formation-and-physical-stability-of-two-phase-solid-dispersion-systems-of-indomethacin-in-supercooled-molten-mixtures-with-different-matrix-formers
#11
Kristian Semjonov, Karin Kogermann, Ivo Laidmäe, Osmo Antikainen, Clare J Strachan, Henrik Ehlers, Jouko Yliruusi, Jyrki Heinämäki
Amorphous solid dispersions (SDs) are a promising approach to improve the dissolution rate of and oral bioavailability of poorly water-soluble drugs. In some cases multi-phase, instead of single-phase, SD systems with amorphous drug are obtained. While it is widely assumed that one-phase amorphous systems are desirable, two-phase systems may still potentially exhibit enhanced stability and dissolution advantages over undispersed systems. The objective of the present study was to understand the solid-state properties of two-phase SDs with amorphous drug and their relation to physical stability...
November 23, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27884758/magnesium-enhances-opioid-induced-analgesia-what-we-have-learnt-in-the-past-decades
#12
REVIEW
Magdalena Bujalska-Zadrożny, Jan Tatarkiewicz, Kamila Kulik, Małgorzata Filip, Marek Naruszewicz
Opioids are increasingly used in alleviating pain, including cancer-related pain and postoperative pain. Unfortunately, the development of tolerance, the resistance of neuropathic pain on opioid analgesia or other undesirable effects may limit their utility. In order to reduce opioid doses, and thereby to avoid the risk of side effects and sudden deaths due to overdosing, attempts have been made to introduce co-analgesics. Due to an increasing amount of data concerning a potential enhance of opioid analgesia by the physiological antagonist of N-methyl-d-aspartate receptors, magnesium ions (Mg(2+)), a concomitant use of such a combination seems to be interesting from a clinical point of view...
November 21, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27866986/modelling-of-in-vitro-and-in-vivo-performance-of-aerosol-emitted-from-different-vibrating-mesh-nebulisers-in-non-invasive-ventilation-circuit
#13
Hoda Rabea, Ahmed M A Ali, Randa Salah Eldin, Maha M Abdelrahman, Amira S A Said, Mohamed E Abdelrahim
Substituting nebulisers by another in non-invasive ventilation circuit (NIV) involves many process variables which must be adjusted to ensure patient optimum therapy. However, there is a doubt when nebulisers use the same technology. Data mining technology based on artificial neural networks and genetic algorithms were used here to model in-vitro inhalation process and predict bioavailability from inhaled doses delivered by three different vibrating mesh nebulisers (VMNs) in NIV. Modelling of data indicated that in-vitro performance of VMNs was dependent mainly on fine particle fraction, mass median aerodynamic diameter (MMAD), total emitted dose (TED) and to lesser extent on nebuliser type...
November 17, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27866016/successful-co-encapsulation-of-benzoyl-peroxide-and-chloramphenicol-in-liposomes-by-a-novel-manufacturing-method-dual-asymmetric-centrifugation
#14
Sveinung G Ingebrigtsen, Nataša Škalko-Basnet, Cristiane de Albuquerque Cavalcanti Jacobsen, Ann Mari Holsæter
Encapsulation of more than one active pharmaceutical ingredient into nanocarriers such as liposomes is an attractive approach to achieve a synergic drug effect and less complicated dosing schedules in multi-drug treatment regimes. Liposomal drug delivery in acne treatment may improve drug efficiency by targeted delivery to pilosebaceous units, reduce adverse effects and improve patient compliance. We therefore aimed to co-encapsulate benzoyl peroxide (BPO) and chloramphenicol (CAM) into liposomes using the novel liposome processing method - dual asymmetric centrifugation (DAC)...
November 16, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27866015/diversity-selection-screening-and-quantitative-structure-activity-relationships-of-osmolyte-like-additive-effects-on-the-thermal-stability-of-a-monoclonal-antibody
#15
Olubukayo-Opeyemi Oyetayo, Oscar Méndez-Lucio, Andreas Bender, Hans Kiefer
Solvents used for therapeutic proteins in downstream processing and in formulations often contain stabilizing additives that inhibit denaturation and aggregation. Such additives are mostly selected based on their positive effect on thermal stability of the protein, and are often derived from naturally occuring osmolytes. To better understand the structural basis underlying the effect of additives, we selected a diverse library of compounds comprising 79 compounds of the polyol, amino acid and methylamine chemical classes and determined the effect of each compound on thermal stability of a monoclonal antibody as a function of compound concentration...
November 16, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27864064/an-emerging-class-of-amphiphilic-dendrimers-for-pharmaceutical-and-biomedical-applications-janus-amphiphilic-dendrimers
#16
REVIEW
Dhiraj R Sikwal, Rahul S Kalhapure, Thirumala Govender
In recent years, a new class of dendrimer, known as Janus dendrimers (JDs), has attracted much attention due to their different structures and properties to the conventional symmetric forms. The broken symmetry of JDs offers the opportunity to form complex self-assembled materials, and presents new sets of properties that are presently inconceivable for homogeneous or symmetrical dendrimers. Due to their unique features, JDs have a promising future in pharmaceutical and biomedical fields, as seen from the recent interest in their application in conjugating multiple drugs and targeting moieties, forming supramolecular hydrogels, enabling micellar delivery systems, and preparing nano-vesicles, known as dendrimersomes, for drug encapsulation...
November 15, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27864063/quercetin-impregnated-chitosan-fibrin-composite-scaffolds-as-potential-wound-dressing-materials-fabrication-characterization-and-in-vivo-analysis
#17
Weslen S Vedakumari, Nazeeha Ayaz, Arun S Karthick, Rethinam Senthil, Thotapalli P Sastry
The present study efforts at fabricating chitosan-fibrin composite (CF) scaffolds impregnated with quercetin for wound dressing application and aims at investigating their physicochemical properties. CF scaffolds were prepared by mixing acidic solution of chitosan with an alkaline solution of fibrin, to which quercetin (Q) was added, homogenized and lyophilized obtain Q-CF scaffold. FTIR spectra were used to determine the interactions between the functional groups of quercetin and CF scaffolds. TGA analysis revealed the decomposition of saccharide rings and amino acids of chitosan and fibrin at the temperature range of 255-400°C...
November 15, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27863308/in-vitro-biopharmaceutical-evaluation-of-ciprofloxacin-metal-cation-complexes-for-pulmonary-administration
#18
J Brillault, F Tewes, W Couet, J C Olivier
Pulmonary delivery of fluoroquinolones (FQs) is an interesting approach to treat lung infections as it may lead to high local concentrations while minimizing systemic exposure. However, FQs have a rapid diffusion through the lung epithelium giving the pulmonary route no advantage compared to the oral route. Interactions between FQs and metal cations form complexes which limit the diffusion through the epithelial barrier and would reduce the absorption of FQs and maintain high concentrations in the lung. The effects of this complexation depend on the FQ and the metal cations and optimum partners should be selected through in vitro experiments prior to aerosol drug formulation...
November 15, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27847331/the-effect-of-additional-aeration-of-liquid-on-the-atomization-process-for-a-pneumatic-nebulizer
#19
M Ochowiak, M Matuszak
At this paper the effect of aeration on the droplet size distribution of the aerosol have been analyzed. The atomization process was carried out using a pneumatic nebulizer which was equipped with a modified nebulizer cup. This modified nebulizer cup was combined with an additional source of gas bubbles. The measurements of the droplet sizes obtained by the use of the digital microphotography method and analyzed by Image-Pro Plus software. The analysis of the experimental studies proved that an increase in the flow rates of additional gas leads to the increase in the number of small droplets and the decrease of the number of drops of large diameter...
November 12, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27845233/ectoine-and-hydroxyectoine-inhibit-thermal-induced-aggregation-and-increase-thermostability-of-recombinant-human-interferon-alfa2b
#20
Faranak Salmannejad, Nastaran Nafissi-Varcheh
This study is to investigate whether ectoines (ectoine and hydroxyectoine) can reduce aggregation of rhIFNα2b in aqueous solutions on thermal stress. The effect of thermal stress condition on the stability was therefore investigated using size exclusion-high performance liquid chromatography (SE-HPLC), different spectroscopic measurements, dynamic light scattering (DLS), electrophoresis, and differential scanning calorimetry (DSC). All experiments were performed in a sodium phosphate buffer system (100mM, pH7)...
November 11, 2016: European Journal of Pharmaceutical Sciences
journal
journal
31514
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"