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Radiology and Oncology

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https://www.readbyqxmd.com/read/29520213/voluntary-deep-inspiration-breath-hold-reduces-the-heart-dose-without-compromising-the-target-volume-coverage-during-radiotherapy-for-left-sided-breast-cancer
#1
Noora Al-Hammadi, Palmira Caparrotti, Carole Naim, Jillian Hayes, Katherine Rebecca Benson, Ana Vasic, Hissa Al-Abdulla, Rabih Hammoud, Saju Divakar, Primoz Petric
Background: During radiotherapy of left-sided breast cancer, parts of the heart are irradiated, which may lead to late toxicity. We report on the experience of single institution with cardiac-sparing radiotherapy using voluntary deep inspiration breath hold (V-DIBH) and compare its dosimetric outcome with free breathing (FB) technique. Patients and methods: Left-sided breast cancer patients, treated at our department with postoperative radiotherapy of breast/chest wall +/- regional lymph nodes between May 2015 and January 2017, were considered for inclusion...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520212/the-influence-of-genetic-variability-on-the-risk-of-developing-malignant-mesothelioma
#2
Alenka Franko, Nika Kotnik, Katja Goricar, Viljem Kovac, Metoda Dodic-Fikfak, Vita Dolzan
Background: Malignant mesothelioma is a rare cancer with poor outcome, associated with asbestos exposure. Reactive oxygen species may play an important role in the mechanism of carcinogenesis; therefore, genetic variability in antioxidative defence may modify an individual's susceptibility to this cancer. This study investigated the influence of functional polymorphisms of NQO1 , CAT , SOD2 and hOGG1 genes, gene-gene interactions and gene-environment interactions on malignant mesothelioma risk...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520211/electrochemotherapy-with-bleomycin-of-different-types-of-cutaneous-tumours-in-a-ferret-mustela-putorius-furo
#3
Jozko Racnik, Tanja Svara, Marko Zadravec, Mitja Gombac, Maja Cemazar, Gregor Sersa, Natasa Tozon
Background: Mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets ( Mustela putorius furo ), and early excisional surgery is usually the treatment of choice. The aim of our study was to investigate the effectiveness of electrochemotherapy (ECT), a new, minimally invasive non-surgical method, as first treatment option of different types of ferret skin tumours located on surgically difficult sites. Materials and methods: A 5-year-old castrated male ferret with two cutaneous masses, presenting 4 months apart and a 7-year-old spayed female ferret with two cutaneous masses, that appeared simultaneously on two locations are presented...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520210/mri-and-11-c-acetate-pet-ct-for-prediction-of-regional-lymph-node-metastasis-in-newly-diagnosed-prostate-cancer
#4
Catrin von Below, Cecilia Wassberg, Rafael Grzegorek, Joel Kullberg, Charlotta Gestblom, Jens Sörensen, Mauritz Waldén, Håkan Ahlström
Background: The aim of the study was to examine the value of quantitative and qualitative MRI and 11 C acetate PET/CT parameters in predicting regional lymph node (LN) metastasis of newly diagnosed prostate cancer (PCa). Patients and methods: Patients with intermediate (n = 6) and high risk (n = 47) PCa underwent 3T MRI (40 patients) and 11 C acetate PET/CT (53 patients) before extended pelvic LN dissection. For each patient the visually most suspicious LN was assessed for mean apparent diffusion coefficient (ADCmean), maximal standardized uptake value (SUVmax), size and shape and the primary tumour for T stage on MRI and ADCmean and SUVmax in the index lesion...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520209/nutrition-of-patients-with-severe-neurologic-impairment
#5
Anija Orel, Matjaz Homan, Rok Blagus, Evgen Benedik, Rok Orel, Natasa Fidler Mis
Background: Commercial enteral formulas are generally recommended for gastrostomy feeding in patients with severe neurologic impairment. However, pureed food diets are still widely used and even gaining popularity among certain groups. We tried to compare the effectiveness of gastrostomy feeding for treatment of severe malnutrition with either enteral formulas or pureed feeds. Patients and methods: A 6-month nutritional intervention was made with 37 malnourished children, adolescents and young adults (2-26 years old) with severe neurologic impairment (Gross Motor Function Classification system [GMFCS] grade V)...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520208/the-impact-of-outpatient-clinical-care-on-the-survival-and-hospitalisation-rate-in-patients-with-alcoholic-liver-cirrhosis
#6
Dejan Majc, Bojan Tepes
Background: In the study, we aimed to determine whether regular outpatient controls in patients with alcoholic liver cirrhosis have an impact on their survival and hospitalisation rates. Patients and methods: We included patients with liver cirrhosis and regular outpatient controls as a prospective study group and patients with liver cirrhosis who were admitted to hospital only in cases of complications as a retrospective control group. The study was conducted between 2006 and 2011...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520207/outcomes-of-the-surgical-treatment-for-adenocarcinoma-of-the-cardia-single-institution-experience
#7
Stojan Potrc, Arpad Ivanecz, Bojan Krebs, Urska Marolt, Bojan Iljevec, Tomaz Jagric
Background: Adenocarcinomas at the cardia are biologically aggressive tumors with poor long-term survival following curative resection. For resectable adenocarcinoma of the cardia, mostly esophagus extended total gastrectomy or esophagus extended proximal gastric resection is performed; however, the surgical approach, transhiatal or transthoracic, is still under discussion. Postoperative morbidity, mortality and long-term survival were analyzed to evaluate the potential differences in clinically relevant outcomes...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520206/impact-factors-for-perioperative-morbidity-and-mortality-and-repercussion-of-perioperative-morbidity-and-long-term-survival-in-pancreatic-head-resection
#8
Stojan Potrc, Arpad Ivanecz, Vid Pivec, Urska Marolt, Sasa Rudolf, Bojan Iljevec, Tomaz Jagric
Background: The focus of the present study was to reveal any impact factors for perioperative morbidity and mortality as well as repercussion of perioperative morbidity on long-term survival in pancreatic head resection. Patients and methods: In a retrospective study, clinic-pathological factors of 240 patients after pancreatic head (PD) or total resection were analyzed for correlations with morbidity, 30- and 90-day mortality, and long-term survival. According to Clavien-Dindo classification, all complications with grade II and more were defined as overall complications (OAC)...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520205/simultaneous-pure-laparoscopic-resection-of-primary-colorectal-cancer-and-synchronous-liver-metastases-a-single-institution-experience-with-propensity-score-matching-analysis
#9
Arpad Ivanecz, Bojan Krebs, Andraz Stozer, Tomaz Jagric, Irena Plahuta, Stojan Potrc
Background: The aim of the study was to compare the outcome of pure laparoscopic and open simultaneous resection of both the primary colorectal cancer and synchronous colorectal liver metastases (SCLM). Patients and methods: From 2000 to 2016 all patients treated by simultaneous resection were assessed for entry in this single center, clinically nonrandomized trial. A propensity score matching was used to compare the laparoscopic group (LAP) to open surgery group (OPEN)...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520204/laparoscopic-parenchyma-sparing-liver-resection-for-colorectal-metastases
#10
Davit L Aghayan, Egidijus Pelanis, Åsmund Avdem Fretland, Airazat M Kazaryan, Mushegh A Sahakyan, Bård I Røsok, Leonid Barkhatov, Bjørn Atle Bjørnbeth, Ole Jakob Elle, Bjørn Edwin
Background: Laparoscopic liver resection (LLR) of colorectal liver metastases (CLM) is increasingly performed in specialized centers. While there is a trend towards a parenchyma-sparing strategy in multimodal treatment for CLM, its role is yet unclear. In this study we present short- and long-term outcomes of laparoscopic parenchyma-sparing liver resection (LPSLR) at a single center. Patients and methods: LLR were performed in 951 procedures between August 1998 and March 2017 at Oslo University Hospital, Oslo, Norway...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520203/prognostic-significance-of-tumor-regression-in-locally-advanced-rectal-cancer-after-preoperative-radiochemotherapy
#11
Mirko Omejc, Maja Potisek
Background: The majority of rectal cancers are discovered in locally advanced forms (UICC stage II, III). Treatment consists of preoperative radiochemotherapy, followed by surgery 6-8 weeks later and finally by postoperative chemotherapy. The aim of this study was to find out if tumor regression affected long-term survival in patients with localy advanced rectal cancer, treated with neoadjuvant radiochemotherapy. Patients and methods: Patients with rectal cancer stage II or III, treated between 2006 and 2010, were included in a retrospective study...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520202/preoperative-intensity-modulated-chemoradiation-therapy-with-simultaneous-integrated-boost-in-rectal-cancer-2-year-follow-up-results-of-phase-ii-study
#12
Jasna But-Hadzic, Vaneja Velenik
Background: The aim of the study was to investigate the feasibility and safety of experimental fractionation using intensity modulated radiation therapy with a simultaneous integrated boost (IMRT-SIB) to shorten the overall treatment time without dose escalation in preoperative radiochemotherapy of locally advanced rectal cancer. Patients and methods: Between January 2014 and November 2015, a total of 51 patients with operable stage II-III rectal adenocarcinoma were treated...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520201/computed-tomographic-perfusion-imaging-for-the-prediction-of-response-and-survival-to-transarterial-chemoembolization-of-hepatocellular-carcinoma
#13
Peter Popovic, Ana Leban, Klara Kregar, Manca Garbajs, Rok Dezman, Matjaz Bunc
Background: The purpose of this retrospective cohort study was to evaluate the clinical value of computed tomographic perfusion imaging (CTPI) parameters in predicting the response to treatment and overall survival in patients with hepatocellular carcinoma (HCC) treated with drug-eluting beads transarterial chemoembolization (DEBTACE). Patients and methods: Between December 2010 and January 2013 eighteen patients (17 men, 1 woman; mean age 69 ± 5.8 years) with intermediate stage HCC underwent CTPI of the liver prior to treatment with DEBTACE...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520200/premalignant-gastric-lesions-in-patients-included-in-national-colorectal-cancer-screening
#14
Bojan Tepes, Maja Seruga, Miroslav Vujasinovic, Dejan Urlep, Liljana Ljepovic, Jurecic Nataša Brglez, Alenka Forte, Ljubec Anita Kek, Miha Skvarc
Background: Gastric cancer is the fifth most common malignancy in the world with almost one million new cases annually. Helicobacter pylori infection causes 89% of all gastric cancers. Premalignant lesions (atrophy and intestinal metaplasia) develop after several decades of inflammation. Secondary prevention with gastroscopy is possible, but it is costly and has a low compliance rate. Alternative procedures like serology testing for pepsinogen I and II and pepsinogen I/II ratio are available to select patients for surveillance gastroscopies...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29520199/helicobacter-pylori-treatment-results-in-slovenia-in-the-period-2013-2015-as-a-part-of-european-registry-on-helicobacter-pylori-management
#15
Bojan Tepes, Marko Kastelic, Miroslav Vujasinovic, Polona Lampic, Maja Seruga, Natasa Brglez Jurecic, Olga P Nyssen, Maria G Donday, Colm O'Morain, Francis Megraud, Adrian G McNicholl, Javier P Gisbert
Background: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in the world affecting over 50% of the world's population. H. pylori is a grade I carcinogen, responsible for the development of 89 % of noncardia gastric cancers. In the present study we analyzed the data for H. pylori eradication treatments in Slovenia. Patients and methods: Slovenia is a part of the European Registry on Helicobacter pylori Management from the beginning...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29333127/quality-assurance-procedures-based-on-dosimetric-gamma-analysis-as-a-fast-reliable-tool-for-commissioning-brachytherapy-treatment-planning-systems
#16
Grzegorz Zwierzchowski, Grzegorz Bieleda, Janusz Skowronek
Background: Fast and easily repeatable methods for commissioning procedures for brachytherapy (BT) treatment planning systems (TPS) are needed. Radiochromic film dosimetry with gamma analysis is widely used in external beam quality assurance (QA) procedures and planar film dosimetry is also increasingly used for verification of the dose distribution in BT applications. Using the gamma analysis method for comparing calculated and measured dose data could be used for commissioning procedures of the newly developed TG-186 and MBDCA calculation algorithms...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29333126/impact-on-radiation-dose-and-volume-v57-gy-of-the-brain-on-recurrence-and-survival-of-patients-with-glioblastoma-multiformae
#17
Igor Stojkovski, Valentina Krstevska, Snezhana Smichkoska
Background: The aim of the study was to analyze impact of irradiated brain volume V57 Gy (volume receiving 57 Gy and more) on time to progression and survival of patients with glioblastoma. Patients and methods: Dosimetric analysis of treatment plan data has been performed on 70 patients with glioblastoma, treated with postoperative radiochemotherapy with temozolomide, followed by adjuvant temozolomide. Patients were treated with 2 different methods of definition of treatment volumes and prescription of radiation dose...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29333125/association-between-slc19a1-gene-polymorphism-and-high-dose-methotrexate-toxicity-in-childhood-acute-lymphoblastic-leukaemia-and-non-hodgkin-malignant-lymphoma-introducing-a-haplotype-based-approach
#18
Barbara Faganel Kotnik, Janez Jazbec, Petra Bohanec Grabar, Cristina Rodriguez-Antona, Vita Dolzan
Background: We investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML). Patients and methods: Eighty-eight children and adolescents with ALL/NHML were investigated for the influence of SLC 19A1 single nucleotide polymorphisms (SNPs) and haplotypes on HD-MTX induced toxicities. Results: Patients with rs2838958 TT genotype had higher probability for mucositis development as compared to carriers of at least one rs2838958 C allele (OR 0...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29333124/long-term-results-of-radiotherapy-in-vulvar-cancer-patients-in-slovenia-between-1997-2004
#19
Helena Barbara Zobec Logar
Background: The aim of this retrospective single institution study was to analyse long term results of vulvar cancer treatment with conventional 2D radiotherapy in Slovenia between years 1997-2004. Patients and methods: Fifty-six patients, median age 74.4 years +/- 9.7 years, mainly stage T2 or T3, were included in the study. All patients were treated with radiotherapy, which was combined with surgery (group A), used as the primary treatment (group B) or at the time of relapse (group C)...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29333123/evaluation-of-deformable-image-registration-dir-methods-for-dose-accumulation-in-nasopharyngeal-cancer-patients-during-radiotherapy
#20
Wannapha Nobnop, Imjai Chitapanarux, Hudsaleark Neamin, Somsak Wanwilairat, Vicharn Lorvidhaya, Taweap Sanghangthum
Introduction: Deformable image registration (DIR) is used to modify structures according to anatomical changes for observing the dosimetric effect. In this study, megavoltage computed tomography (MVCT) images were used to generate cumulative doses for nasopharyngeal cancer (NPC) patients by various DIR methods. The performance of the multiple DIR methods was analysed, and the impact of dose accumulation was assessed. Patients and methods: The study consisted of five NPC patients treated with a helical tomotherapy unit...
December 2017: Radiology and Oncology
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