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Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu

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https://www.readbyqxmd.com/read/30210227/evaluation-of-menopausal-status-among-breast-cancer-patients-with-chemotherapy-induced-amenorrhea
#1
Bailin Zhang, Jinqi Wu, Rongshou Zheng, Qian Zhang, Margaret Zhuoer Wang, Jun Qi, Haijing Liu, Yipeng Wang, Yang Guo, Feng Chen, Jing Wang, Wenyue Lyu, Jidong Gao, Yi Fang, Wanqing Chen, Xiang Wang
Objective: In patients with chemotherapy-induced amenorrhea (CIA), the menopausal status is ambiguous and difficult to evaluate. This study aimed to establish a discriminative model to predict and classify the menopausal status of breast cancer patients with CIA. Methods: This is a single center hospital-based study from 2013 to 2016. The menopausal age distribution and accumulated incidence rate of CIA are described. Multivariate models were adjusted for established and potential confounding factors including age, serum concentration of estradiol (E2) and follicle-stimulating hormone (FSH), feeding, pregnancy, parity, abortions, and body mass index (BMI)...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210226/increased-incidence-of-chemoport-related-thrombosis-in-patients-with-colorectal-cancer-receiving-bevacizumab-a-single-institutional-experience
#2
Jwa Hoon Kim, Jeong Eun Kim, Yong Sang Hong, Sun Young Kim, Kyu-Pyo Kim, Ki Eun Choi, Ji Hoon Shin, Tae Won Kim
Objective: Chemoport-related thrombosis (CRT) is a serious complication that causes morbidities and interrupts administration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer (CRC) patients treated with bevacizumab (BEV). Methods: We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEV using a chemoport between 2014 and 2016. Results: The participants had a median age of 58 (18-85) years, and 60...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210225/a-nomogram-to-predict-prognosis-for-gastric-cancer-with-peritoneal-dissemination
#3
Shi Chen, Xijie Chen, Runcong Nie, Liying Ou Yang, Aihong Liu, Yuanfang Li, Zhiwei Zhou, Yingbo Chen, Junsheng Peng
Objective: To identify independent prognostic factors to be included in a nomogram to predict the prognosis of gastric cancer patients with peritoneal dissemination. Methods: This is a retrospective study on 684 patients with a histological diagnosis of gastric cancer with peritoneal dissemination from the Sun Yat-sen University Cancer Center as the development set, and 62 gastric cancer patients from the Sixth Affiliated Hospital of Sun Yat-sen University as the validation group...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210224/annual-cost-of-illness-of-stomach-and-esophageal-cancer-patients-in-urban-and-rural-areas-in-china-a-multi-center-study
#4
Zhixun Yang, Hongmei Zeng, Ruyi Xia, Qian Liu, Kexin Sun, Rongshou Zheng, Siwei Zhang, Changfa Xia, He Li, Shuzheng Liu, Zhiyi Zhang, Yuqin Liu, Guizhou Guo, Guohui Song, Yigong Zhu, Xianghong Wu, Bingbing Song, Xianzhen Liao, Yanfang Chen, Wenqiang Wei, Guihua Zhuang, Wanqing Chen
Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers. Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210223/a-radiomic-nomogram-based-on-an-apparent-diffusion-coefficient-map-for-differential-diagnosis-of-suspicious-breast-findings
#5
Bin Hu, Ke Xu, Zheng Zhang, Ruimei Chai, Shu Li, Lina Zhang
Objective: To develop and validate a radiomic nomogram based on an apparent diffusion coefficient (ADC) map for differentiating benign and malignant lesions in suspicious breast findings classified as Breast Imaging Reporting and Data System (BI-RADS) category 4 on breast magnetic resonance imaging (MRI). Methods: Eighty-eight patients diagnosed with BI-RADS 4 findings on breast MRI in the First Affiliated Hospital of China Medical University from December 2014 to December 2015 were retrospectively analyzed in this study...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210222/differential-study-of-dce-mri-parameters-in-spinal-metastatic-tumors-brucellar-spondylitis-and-spinal-tuberculosis
#6
Pengfei Qiao, Pengfei Zhao, Yang Gao, Yuzhen Bai, Guangming Niu
Objective: In the present study, spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the value of DCE-MRI in the differential diagnosis of these diseases. Methods: Patients with brucellar spondylitis, spinal tuberculosis or a spinal metastatic tumor (30 cases of each) received conventional MRI and DCE-MRI examination. The volume transfer constant (Ktrans ), rate constant (Kep ), extravascular extracellular volume fraction (Ve ) and plasma volume fraction (Vp ) of the diseased vertebral bodies were measured on the perfusion parameter map, and the differences in these parameters between the patients were compared...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210221/radiomic-analysis-of-pulmonary-ground-glass-opacity-nodules-for-distinction-of-preinvasive-lesions-invasive-pulmonary-adenocarcinoma-and-minimally-invasive-adenocarcinoma-based-on-quantitative-texture-analysis-of-ct
#7
Wei Li, Xuexiang Wang, Yuwei Zhang, Xubin Li, Qian Li, Zhaoxiang Ye
Objective: To identify the differences among preinvasive lesions, minimally invasive adenocarcinomas (MIAs) and invasive pulmonary adenocarcinomas (IPAs) based on radiomic feature analysis with computed tomography (CT). Methods: A total of 109 patients with ground-glass opacity lesions (GGOs) in the lungs determined by CT examinations were enrolled, all of whom had received a pathologic diagnosis. After the manual delineation and segmentation of the GGOs as regions of interest (ROIs), the patients were subdivided into three groups based on pathologic analyses: the preinvasive lesions (including atypical adenomatous hyperplasia and adenocarcinoma in situ ) subgroup, the MIA subgroup and the IPA subgroup...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210220/computed-tomography-based-radiomics-for-prediction-of-neoadjuvant-chemotherapy-outcomes-in-locally-advanced-gastric-cancer-a-pilot-study
#8
Zhenhui Li, Dafu Zhang, Youguo Dai, Jian Dong, Lin Wu, Yajun Li, Zixuan Cheng, Yingying Ding, Zaiyi Liu
Objective: The standard treatment for patients with locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery. The aim of this study was to investigate the wealth of radiomics for pre-treatment computed tomography (CT) in the prediction of the pathological response of locally advanced gastric cancer with preoperative chemotherapy. Methods: Thirty consecutive patients with CT-staged II/III gastric cancer receiving neoadjuvant chemotherapy were enrolled in this study between December 2014 and March 2017...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210219/radiomics-approach-for-preoperative-identification-of-stages-i-ii-and-iii-iv-of-esophageal-cancer
#9
Lei Wu, Cong Wang, Xianzheng Tan, Zixuan Cheng, Ke Zhao, Lifen Yan, Yanli Liang, Zaiyi Liu, Changhong Liang
Objective: To predict preoperative staging using a radiomics approach based on computed tomography (CT) images of patients with esophageal squamous cell carcinoma (ESCC). Methods: This retrospective study included 154 patients (primary cohort: n=114; validation cohort: n=40) with pathologically confirmed ESCC. All patients underwent a preoperative CT scan from the neck to abdomen. High throughput and quantitative radiomics features were extracted from the CT images for each patient...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30210218/application-of-quantitative-imaging-in-oncologic-management
#10
Changhong Liang
No abstract text is available yet for this article.
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046232/imaging-evaluation-of-sorafenib-for-treatment-of-advanced-hepatocellular-carcinoma
#11
Tianying Zheng, Hanyu Jiang, Yi Wei, Zixing Huang, Jie Chen, Ting Duan, Bin Song
Sorafenib, which is a novel targeted agent, plays an important role in treating advanced hepatocellular carcinoma (HCC) through its antiangiogenic and antiproliferative effects. However, conventional morphology-based radiographic evaluation systems may underestimate the efficacy of sorafenib in HCC due to a lack of apparent tumor shrinkage or altered tumor morphology in many cases. This calls for the development of more accurate imaging methods for evaluating sorafenib. The introduction of tumor burden measurements based on viability and other evolving imaging approaches for assessing therapeutic effects are promising for overcoming some of the limitations of the morphology-based criteria...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046231/down-staging-depth-score-to-predict-outcomes-in-locally-advanced-rectal-cancer-achieving-ypi-stage-after-neoadjuvant-chemo-radiotherapy-versus-de-novo-stage-pi-cohort-a-propensity-score-matched-analysis
#12
Ning Li, Jing Jin, Jing Yu, Shuai Li, Yuan Tang, Hua Ren, Wenyang Liu, Shulian Wang, Yueping Liu, Yongwen Song, Hui Fang, Zihao Yu, Yexiong Li
Objective: Prognosis of patients with locally advanced rectal cancer (LARC) but achieving ypT1-2N0 stage after neoadjuvant concurrent chemo-radiotherapy (CRT) has been shown to be favorable. This study aims to determine whether the long-term outcome of ypT1-2N0 cases can be comparable to that of pT1-2N0 cohort that received definitive surgery for early disease. Method: From January 2008 to December 2013, 449 consecutive patients with rectal cancer were treated and their outcome maintained in a database...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046230/clinicopathological-features-and-surgical-outcomes-of-four-rare-subtypes-of-primary-liver-carcinoma
#13
Zhiyu Li, Xiaolong Wu, Xinyu Bi, Yefan Zhang, Zhen Huang, Haizhen Lu, Hong Zhao, Jianjun Zhao, Jianguo Zhou, Muxing Li, Jianming Ying, Jianqiang Cai
Objective: This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features. Methods: The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes: clear cell carcinoma (CCC), giant cell carcinoma (GCC), sarcomatoid carcinoma (SC), and combined hepatocellular-cholangiocarcinoma (CHC) between October 1998 and August 2015 were reviewed...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046229/mat1-correlates-with-molecular-subtypes-and-predicts-poor-survival-in-breast-cancer
#14
Hanxiao Xu, Xianguang Bai, Shengnan Yu, Qian Liu, Richard G Pestell, Kongming Wu
Objective: Menage a trois 1 (MAT1) is a targeting subunit of cyclin-dependent kinase-activating kinase and general transcription factor IIH kinase, which modulates cell cycle, transcription and DNA repair. Its dysregulation is responsible for diseases including cancers. To further explore the role of MAT1 in breast cancer, we investigated the pathways in which MAT1 might be involved, the association between MAT1 and molecular subtypes, and the role of MAT1 in clinical outcomes of breast cancer patients...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046228/presence-of-circulating-tumor-cells-is-associated-with-metabolic-related-variables-in-postoperative-patients-with-early-stage-breast-cancer
#15
Yumei Shi, Guochun Zhang, Yulei Wang, Chongyang Ren, Lingzhu Wen, Wenzhen Zhu, Xiaoqing Chen, Ning Liao
Objective: Although circulating tumor cells (CTCs) have been well-established as promising prognostic biomarkers in both early breast cancer and metastatic settings, little is known regarding the prognostic relevance of CTCs in the long-term postoperative monitoring of patients with non-metastatic breast cancer (non-MBC). In this study, we investigated the associations of CTCs with clinicopathological features and metabolic-related variables, such as obesity and hyperglycemia. Methods: In this retrospective study, we recruited 264 patients with postoperative stage I-III breast cancer at Guangdong General Hospital from January 2009 to December 2015...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046227/treatment-patterns-for-adjuvant-docetaxel-based-chemotherapy-in-early-stage-breast-cancer-in-china-a-pooled-retrospective-analysis-of-four-observational-studies
#16
Binghe Xu, Zhimin Shao, Shui Wang, Zefei Jiang, Xichun Hu, Xiaohua Zhang, Xiru Li, Jinping Liu, Mengquan Li, Shu Wang
Objective: Adjuvant docetaxel-based chemotherapy is frequently used for operable early breast cancer (EBC). This study investigated patterns of use of docetaxel (T) in real-life clinical practice in China. Methods: This was a retrospective pooled analysis of the Asia-Pacific Breast Initiatives (APBI) I (2006-2008) and II (2009-2011) registries, and two Chinese observational studies; BC STATE (2011-2014) and BC Local Registry (2007-2010). Female Chinese adults (≥18 years) with operable breast cancer treated with docetaxel-based adjuvant chemotherapy were included in the analysis...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046226/combined-peripheral-natural-killer-cell-and-circulating-tumor-cell-enumeration-enhance-prognostic-efficiency-in-patients-with-metastatic-triple-negative-breast-cancer
#17
Xiaoran Liu, Ran Ran, Bin Shao, Hope S Rugo, Yanlian Yang, Zhiyuan Hu, Zewen Wei, Fengling Wan, Weiyao Kong, Guohong Song, Hanfang Jiang, Xu Liang, Ruyan Zhang, Ying Yan, Guobing Xu, Huiping Li
Objective: Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis. Circulating tumor cells (CTCs) are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival (PFS) is controversial. We aim to verify their predictive value in TNBC. Methods: In present prospective cohort study, we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC (taken at inclusion in this study) and analyzed correlations between CTC numbers and outcomes and other clinical parameters...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046225/effectiveness-and-safety-of-different-amifostine-regimens-preliminary-results-of-a-phase-ii-multicenter-randomized-controlled-trial
#18
Hui Chang, Wei Yi, Xiaohui Wang, Yalan Tao, Xin Yang, Chen Chen, Wenwen Zhang, Shu Zhou, Songran Liu, Xiaohui Li, Shirong Ding, Jing Li, Gong Li, Xunfan Shao, Yimin Liu, Weishu Song, Yunfei Xia
Objective: The radioprotective effects of amifostine remain uncertain in patients with nasopharyngeal carcinoma (NPC), and adverse effects and cost limit generalization of its classical everyday regimen. This phase II multicenter randomized controlled trial aimed to explore whether amifostine could ameliorate the toxicities of NPC patients in the era of intensity-modulated radiotherapy (IMRT), and to compare different regimens of amifostine on effectiveness and safety. Methods: Patients with stage I-IVB NPC were involved prospectively from January 1st, 2013...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046224/incidence-and-mortality-of-laryngeal-cancer-in-china-2008-2012
#19
Yuqin Liu, Qin Zhao, Gaoheng Ding, Yitong Zhu, Wenying Li, Wanqing Chen
Objective: To analyze the incidence and mortality rates of laryngeal cancer in China from 2008 to 2012. Methods: Incident and death cases of laryngeal cancer were retrieved from the National Central Cancer Registry (NCCR) database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of laryngeal cancer were calculated by area (urban/rural), region (eastern, middle, western), gender and age group (0, 1-4, 5-9, …, 85+)...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30046223/incidence-and-mortality-of-stomach-cancer-in-china-2014
#20
Lei Yang, Rongshou Zheng, Ning Wang, Yannan Yuan, Shuo Liu, Huichao Li, Siwei Zhang, Hongmei Zeng, Wanqing Chen
Objective: In this study, we aimed to estimate the updated incidence and mortality rate of stomach cancer based on the cancer registration data in 2014, collected by the National Central Cancer Registry of China (NCCRC). Methods: In 2017, 339 registries' data were qualified based on the criteria of data quality control of the NCCRC. Cases of stomach cancer were retrieved from the national database. We estimated numbers of stomach cancer cases and deaths in China using age-specific rates and corresponding national population stratified by area, sex, age-group (0, 1-4, 5-9, 10-14, …, 85+)...
June 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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