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Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu

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https://www.readbyqxmd.com/read/27877014/prognostic-potential-of-an-immune-score-based-on-the-density-of-cd8-t-cells-cd20-b-cells-and-cd33-p-stat1-double-positive-cells-and-hmgb1-expression-within-cancer-nests-in-stage-iiia-gastric-cancer-patients
#1
Jun Dong, Jiao Li, Shiming Liu, Xingyu Feng, Shi Chen, Zhiwei Zhou, Yingbo Chen, Xiaoshi Zhang
OBJECTIVE: There is heterogeneity in the prognosis of gastric cancers staged according to the tumornodes- metastasis (TNM) system. This study evaluated the prognostic potential of an immune score system to supplement the TNM staging system. METHODS: An immunohistochemical analysis was conducted to assess the density of T cells, B cells, and myeloid-derived suppressor cells (MDSCs) in cancer tissues from 100 stage IIIA gastric cancer patients; the expression of the high-mobility group protein B1 (HMGB1) was also evaluated in cancer cells...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877013/the-association-of-tnf-308-g-a-gene-polymorphisms-and-hepatocellular-carcinoma-risk-a-meta-analysis
#2
Qing Sun, Xuedan Guo, Qi Wang, Fan Zhao
OBJECTIVE: Many studies have examined the association between the TNF-308 G/A polymorphism gene polymorphisms and hepatocellular carcinoma risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. METHODS: The PubMed and CNKI (China National Knowledge Infrastructure) database was searched for case-control studies. Odds ratios (OR) with 95% CIs were used to determine the strength of association between the TNF-308 G/A polymorphisms and HCC risk...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877012/simultaneous-hepatic-resection-benefits-patients-with-synchronous-colorectal-cancer-liver-metastases
#3
Yuan Li, Xinyu Bi, Jianjun Zhao, Zhen Huang, Jianguo Zhou, Zhiyu Li, Yefan Zhang, Hong Zhao, Jianqiang Cai
OBJECTIVE: The safety of the simultaneous resection of synchronous colorectal cancer liver metastases (SCRLM) is still being debated. However, this simultaneous operative approach is more commonly adopted at present than in the past. Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study. METHODS: All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877011/analysis-of-clinical-characteristics-and-treatment-of-pancreatic-cystic-tumors
#4
Lei You, Jianchun Xiao, Zhe Cao, Wanying Zhang, Quan Liao, Menghua Dai, Taiping Zhang, Yupei Zhao
OBJECTIVE: To summarize experience in the diagnosis and treatment of pancreatic cystic neoplasms. METHODS: This is a retrospective study of 207 patients who were diagnosed with pancreatic cystic tumors at Peking Union Medical College Hospital between Jan 2009 and Mar 2014. Clinical data, such as clinical manifestations, radiological and pathological images and surgical recordings, were collected. RESULTS: Of the 207 included patients, females accounted for 76...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877010/comparison-of-lymph-node-number-and-prognosis-in-gastric-cancer-patients-with-perigastric-lymph-nodes-retrieved-by-surgeons-and-pathologists
#5
Lixin Jiang, Zengwu Yao, Yifei Zhang, Jinchen Hu, Dawei Zhao, Huiyuan Zhai, Xixun Wang, Zhenbin Zhang, Dong Wang
OBJECTIVE: To compare the numbers of positive and total lymph nodes and prognosis in gastric cancer patients whose perigastric lymph node retrieval was performed by surgeons and pathologists. METHODS: We conducted a retrospective analysis of clinical and follow-up data from 1, 056 patients who underwent gastric cancer D2 radical lymph node resection between January 2008 and December 2010 in the Gastrointestinal Surgery Department of Yantai Yuhuangding Hospital. The follow-up ended in December 2015...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877009/characteristics-of-gastric-cancer-recurrence-five-or-more-years-after-curative-gastrectomy
#6
Chang-Hyun Shin, Woo-Yong Lee, Seung-Woo Hong, Yeo-Goo Chang
OBJECTIVE: To investigate the characteristics of recurrences that occurred 5 or more years after curative resection for gastric cancer. METHODS: We analyzed recurrences among 1,299 patients with gastric cancer who underwent curative operations at the Department of Surgery, Inje University Seoul Paik Hospital between September 1998 and December 2002. Recurrences were classified as within 2 years (early), 2-5 years (intermediate), and more than 5 years (late) after gastrectomy...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877008/detection-of-alk-translocation-in-non-small-cell-lung-carcinoma-nsclc-and-its-clinicopathological-significance-using-the-ventana-immunohistochemical-staining-method-a-single-center-large-scale-investigation-of-1-504-chinese-han-patients
#7
Lin Yang, Yun Ling, Lei Guo, Di Ma, Xuemin Xue, Bingning Wang, Junling Li, Jianming Ying
OBJECTIVE: The novel fully automated immunohistochemistry (IHC) assay-Ventana anaplastic lymphoma kinase (ALK)-D5F3 for screening ALK rearrangements has been approved by China's Food and Drug Administration in 2013, our previous study disclosed a highly specificity and sensitivity nearly 100%, and its efficacy needs to be evaluated in a large cohort of primary lung adenocarcinoma patients, and to compare clinicopathological features with ALK (+) and ALK (-) lung adenocarcinoma. METHODS: A total of 1,504 consecutive surgical lung adenocarcinoma cases of Chinese Han population were collected and re-diagnosed according to the 2011 multidisciplinary classification of lung adenocarcinoma...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877007/further-understanding-of-an-uncommon-disease-of-combined-small-cell-lung-cancer-clinical-features-and-prognostic-factors-of-114-cases
#8
Yu Men, Zhouguang Hui, Jun Liang, Qinfu Feng, Dongfu Chen, Hongxing Zhang, Zefen Xiao, Zongmei Zhou, Weibo Yin, Luhua Wang
OBJECTIVE: Combined small cell lung cancer (C-SCLC) is an uncommon subgroup of small cell lung cancer (SCLC) and few clinical data can be referred. Our study is to investigate the clinical features and prognostic factors of C-SCLC, as well as the role of multimodality treatment. METHODS: Between January 2004 and December 2012, patients with histologically diagnosed C-SCLC were retrospectively analyzed. The survivals were evaluated with the Kaplan-Meier method. Univariate and multivariate analyses were used to evaluate potential prognostic factors...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877006/early-prediction-of-pathological-outcomes-to-neoadjuvant-chemotherapy-in-breast-cancer-patients-using-automated-breast-ultrasound
#9
Xinguang Wang, Ling Huo, Yingjian He, Zhaoqing Fan, Tianfeng Wang, Yuntao Xie, Jinfeng Li, Tao Ouyang
OBJECTIVE: Early assessment of response to neoadjuvant chemotherapy (NAC) for breast cancer allows therapy to be individualized. The optimal assessment method has not been established. We investigated the accuracy of automated breast ultrasound (ABUS) to predict pathological outcomes after NAC. METHODS: A total of 290 breast cancer patients were eligible for this study. Tumor response after 2 cycles of chemotherapy was assessed using the product change of two largest perpendicular diameters (PC) or the longest diameter change (LDC)...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27877005/revalidation-of-a-prognostic-score-model-based-on-complete-blood-count-for-nasopharyngeal-carcinoma-through-a-prospective-study
#10
Xiaohui Li, Hui Chang, Yalan Tao, Xiaohui Wang, Jin Gao, Wenwen Zhang, Chen Chen, Yunfei Xia
OBJECTIVE: In our previous work, we incorporated complete blood count (CBC) into TNM stage to develop a new prognostic score model, which was validated to improve prediction efficiency of TNM stage for nasopharyngeal carcinoma (NPC). The purpose of this study was to revalidate the accuracy of the model, and its superiority to TNM stage, through data from a prospective study. METHODS: CBC of 249 eligible patients from the 863 Program No. 2006AA02Z4B4 was evaluated...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647976/experience-with-intraoperative-radiotherapy-for-breast-cancer-the-geneva-university-hospital-s-experience
#11
Emanuela Esposito, Michae Douek
No abstract text is available yet for this article.
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647975/intraoperative-radiation-therapy-deserves-to-be-made-more-readily-available-to-patients
#12
Mohammed Keshtgar, Norman R Williams
No abstract text is available yet for this article.
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647974/endostatin-enhances-antitumor-effect-of-tumor-antigen-pulsed-dendritic-cell-therapy-in-mouse-xenograft-model-of-lung-carcinoma
#13
Jing Liang, Xiaolin Liu, Qi Xie, Guoling Chen, Xingyu Li, Yanrui Jia, Beibei Yin, Xun Qu, Yan Li
OBJECTIVE: To investigate the antitumor effect of endostatin combined with tumor antigen-pulsed dendritic cell (DC)-T cell therapy on lung cancer. METHODS: Transplanted Lewis lung cancer (LLC) models of C57BL/6 mice were established by subcutaneous injection of LLC cells in left extremity axillary. Tumor antigen-pulsed DC-T cells from spleen cells and bone of mice were cultured in vitro. Tumor-bearing mice were randomly divided into three groups, including DC-T+endostatin group, DC-T group, and phosphate-buffered saline (PBS) control group...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647973/a-phase-i-trial-of-an-oral-subtype-selective-histone-deacetylase-inhibitor-chidamide-in-combination-with-paclitaxel-and-carboplatin-in-patients-with-advanced-non-small-cell-lung-cancer
#14
Xingsheng Hu, Lin Wang, Lin Lin, Xiaohong Han, Guifang Dou, Zhiyun Meng, Yuankai Shi
OBJECTIVE: This phase I study was to evaluate safety, maximum tolerated dose, pharmacokinetics and preliminary antitumor activity of chidamide, a novel subtype-selective histone deacetylase (HDAC) inhibitor, in combination with paclitaxel and carboplatin in patients with advanced non-small cell lung cancer (NSCLC). METHODS: Ten patients received oral chidamide 20, 25, or 30 mg twice per week continuously with paclitaxel (175 mg/m(2)) and carboplatin [area under the curve (AUC) 5 mg/mL/min] administered in a 3-week cycle...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647972/a-case-control-study-about-the-association-between-vascular-endothelial-growth-inhibitor-gene-polymorphisms-and-breast-cancer-risk-in-female-patients-in-northeast-china
#15
Shaoli Han, Lei Liu, Fengyan Xu, Shuang Chen, Weiguang Yuan, Zhenkun Fu, Dalin Li, Dianjun Li
OBJECTIVE: The inhibition of the neovascularization in tumors is a potential therapeutic target of cancer. Vascular endothelial growth inhibitor (VEGI) is a member of the TNF superfamily which has the ability to suppress the formation of new vessels in tumors. In order to study the association between VEGI gene polymorphisms and breast cancer risk, a case-control study was conducted in Chinese Han women in Northeast China. METHODS: Our study involved 708 female breast cancer patients and 685 healthy volunteers...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647971/radical-nerve-dissection-for-the-carcinoma-of-head-of-pancreas-report-of-30-cases
#16
Qing Lin, Langping Tan, Yu Zhou, Quanbo Zhou, Rufu Chen
OBJECTIVE: To explore the clinical value of the radical nerve dissection (RND) for the carcinoma of head of pancreas (CHP). METHODS: The clinical and pathological data of 30 CHP patients who underwent RND in our hospital were retrospectively analyzed, with an attempt to explore the safety and short-term efficacy of this procedure. RESULTS: Among these 30 patients, the operative time was (351±61) min, the intra-operative blood loss was 350 (range, 300-600) mL, and the grades B and C pancreatic fistula was 23...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647970/total-mesopancreas-excision-for-pancreatic-head-cancer-analysis-of-120-cases
#17
Wenguang Wu, Xu'an Wang, Xiangsong Wu, Maolan Li, Hao Weng, Yang Cao, Ruifa Bao, Sijun Su, Jianhua Lu, Wei Gong, Weibin Shi, Jun Gu, Xuefeng Wang, Yingbin Liu, Zhiwei Quan, Shuyou Peng
OBJECTIVE: To evaluate the feasibility and safety of total mesopancreas excision (TMpE) in the treatment of pancreatic head cancer. METHODS: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. RESULTS: The mean operative time was (275.0±50.2) min and the average intra-operative blood loss was (390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647969/comparison-of-survival-outcomes-between-transthoracic-and-transabdominal-surgical-approaches-in-patients-with-siewert-ii-iii-esophagogastric-junction-adenocarcinoma-a-single-institution-retrospective-cohort-study
#18
Weihan Zhang, Xinzu Chen, Kai Liu, Kun Yang, Xiaolong Chen, Ying Zhao, Yongfan Zhao, Jiaping Chen, Longqi Chen, Jiankun Hu
OBJECTIVE: To compare the survival outcomes of transabdominal (TA) and transthoracic (TT) surgical approaches in patients with Siewert-II/III esophagogastric junction adenocarcinoma. METHODS: This retrospective study was conducted in patients with Siewert-II/III esophagogastric junction adenocarcinoma who underwent either TT or TA operations in the West China Hospital between January 2006 and December 2009. RESULTS: A total of 308 patients (109 in the TT and 199 in the TA groups) were included in this study with a follow-up rate of 87...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647968/dna-image-cytometry-test-for-primary-screening-of-esophageal-cancer-a-population-based-multi-center-study-in-high-risk-areas-in-china
#19
Meng Wang, Changqing Hao, Qing Ma, Guohui Song, Shanrui Ma, Deli Zhao, Lin Zhao, Xinqing Li, Wenqiang Wei
OBJECTIVE: To evaluate the feasibility of DNA image cytometry (DNA-ICM) as a primary screening method for esophageal squamous cell cancer (ESCC). METHODS: A total of 5,382 local residents aged 40-69 years from three high-risk areas in China (Linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province) from 2008 to 2011 were recruited in this population-based screening study. And 2,526 subjects declined to receive endoscopic biopsy examination with Lugol's iodine staining, while 9 and 815 subjects were excluded from liquid-based cytology and DNA-ICM test respectively due to slide quality...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27647967/evaluation-of-rational-extent-lymphadenectomy-for-local-advanced-gastric-cancer
#20
Han Liang, Jingyu Deng
Based upon studies from randomized clinical trials, the extended (D2) lymph node dissection is now recommended as a standard procedure for local advanced gastric cancer worldwide. However, the rational extent lymphadenectomy for local advanced gastric cancer has remained a topic of debate in the past decades. Due to the limitation of low metastatic rate in para-aortic nodes (PAN) in JCOG9501, the clinical benefit of D2+ para-aortic nodal dissection (PAND) for patients with stage T4 and/or stage N3 disease, which is very common in China and other countries except Japan and Korea, cannot be determined...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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