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Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu

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https://www.readbyqxmd.com/read/29353982/remarkably-different-results-between-two-studies-from-north-america-on-genomic-mutations-and-sensitivity-to-dna-demethylating-agents-for-myelodysplastic-syndromes
#1
Guiping Wang, Shanshan Guo, Huashi Xiao, Liang Zong, Tetsuya Asakawa, Masanobu Abe, Wenqing Hu, Jiafu Ji
No abstract text is available yet for this article.
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353981/retrospective-analysis-of-interventional-treatment-of-hepatic-metastasis-from-gastroenteropancreatic-neuroendocrine-tumors
#2
Peng Liu, Xu Zhu, Jie Li, Ming Lu, Jiahua Leng, Ying Li, Jiangyuan Yu
Objective: To analyze the angiography appearance of liver metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs), and evaluate the clinical efficacy and prognostic factors of interventional treatment for hepatic metastases. Methods: Fifty GEP-NETs patients with hepatic metastases were treated from January 2012 to December 2016, and received transarterial embolization (TAE) in the hepatic tumor or hepatic arterial infusion chemotherapy (HAIC). All patients received 179 times of the intervention therapy in total...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353980/hoxc10-up-regulation-promotes-gastric-cancer-cell-proliferation-and-metastasis-through-mapk-pathway
#3
Chen Guo, Jianing Hou, Sheng Ao, Xingming Deng, Guoqing Lyu
Objective: As an important regulator of embryonic morphogenesis, homeodomain-containing gene 10 (HOXC10) has been found to promote progression of human cancers and its expression indicates poor survival outcome. However, very few studies are available on the role of HOXC10 in gastric carcinoma. Therefore, the aim of this study was to determine the role of HOXC10 in gastric cancer and the potential mechanism underlying its function for cancer biology. Methods: A primary gastric cancer mouse model was obtained via intra-gastric wall injection of gastric cancer cells and was used to evaluate the function of HOXC10 during gastric cancer progression in vivo...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353979/prognostic-value-of-pre-and-post-transplantation-18f-fluorodeoxyglucose-positron-emission-tomography-results-in-non-hodgkin-lymphoma-patients-receiving-autologous-stem-cell-transplantation
#4
Zhitao Ying, Lan Mi, Xuejuan Wang, Yuewei Zhang, Zhi Yang, Yuqin Song, Xiaopei Wang, Wen Zheng, Ningjing Lin, Meifeng Tu, Yan Xie, Lingyan Ping, Chen Zhang, Weiping Liu, Lijuan Deng, Jun Zhu
Objective: High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) is the standard of care in the upfront or relapsed/refractory setting in some patients with non-Hodgkin lymphoma (NHL). However, a proportion of patients do not respond to ASCT. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been widely used for staging, response evaluation, and prognosis prediction. Here, we investigated the prognostic role of PET/CT in NHL patients before and after ASCT...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353978/survival-difference-between-egfr-del19-and-l858r-mutant-advanced-non-small-cell-lung-cancer-patients-receiving-gefitinib-a-propensity-score-matching-analysis
#5
Minglei Zhuo, Qiwen Zheng, Jun Zhao, Meina Wu, Tongtong An, Yuyan Wang, Jianjie Li, Shuhang Wang, Jia Zhong, Xue Yang, Hanxiao Chen, Bo Jia, Zhi Dong, Emei Gao, Jingjing Wang, Ziping Wang
Objective: Although superior clinical benefits of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in the treatment of advanced non-small-cell lung cancer (NSCLC) had been reported, the survival difference between exon 19 deletion (Del19) and exon 21 Leu858Arg substitution (L858R) remains controversial. The purpose of this study is to investigate the differences in progression-free survival (PFS) and overall survival (OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353977/uncommon-egfr-mutations-in-a-cohort-of-chinese-nsclc-patients-and-outcomes-of-first-line-egfr-tkis-and-platinum-based-chemotherapy
#6
Jinpeng Shi, Hui Yang, Tao Jiang, Xuefei Li, Chao Zhao, Limin Zhang, Sha Zhao, Xiaozhen Liu, Yijun Jia, Yan Wang, Lei Xi, Shijia Zhang, Chunxia Su, Shengxiang Ren, Caicun Zhou
Objective: Data on the clinical activity of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer (NSCLC) and uncommon EGFR mutations remain insufficient. This study aimed to investigate the effect of first-line EGFR-TKIs or platinum-based chemotherapy in NSCLC patients with uncommon EGFR mutations. Methods: We retrospectively enrolled 504 patients with EGFR-mutant NSCLC. The clinical characteristics and treatment outcomes were collected and compared between patients with common and uncommon EGFR-mutant NSCLC...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353976/targeted-therapy-for-leptomeningeal-metastases-in-non-small-cell-lung-cancer-changing-treatment-paradigms
#7
Binay Kumar Shah, Isaac Pak, Nibash Budhathoki, Kayla Buker
Leptomeningeal metastasis is an uncommon but serious complication in patients with advanced cancers. Leptomeningeal metastasis is diagnosed in approximately 5% of the patients, most commonly among patients with cancers of breast and lung, melanoma, and gastrointestinal malignancies. Treatment goal is to improve survival and quality of the patients. Use of targeted therapies and immunotherapy has led to improved survival of patients with non-small cell lung cancer (NSCLC). In this article, we review emerging data on use of mutation-specific agents and immunotherapy in the treatment of leptomeningeal metastasis among patients with NSCLC...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353975/debulking-surgery-and-hyperthermic-intrathoracic-chemotherapy-hithoc-for-lung-cancer
#8
Marcello Migliore
No abstract text is available yet for this article.
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353974/outcome-and-prognostic-factors-in-110-consecutive-patients-with-primary-uterine-leiomyosarcoma-a-rare-cancer-network-study
#9
Alessandra Franzetti Pellanda, Berardino De Bari, Elisabeth Deniaud-Alexandre, Marco Krengli, Paul Van Houtte, Antonella Richetti, Salvador Villà, Hadassah Goldberg, Ewa Szutowicz-Zielińska, Michel Bolla, Heidi Rutten, Marc Van Eijkeren, Philip Poortmans, Guido Henke, Yavuz Anacak, Steve Chan, Christine Landmann, Carine Kirkove, Luciano Scandolaro, Jacques Bernier, René-Olivier Mirimanoff, Mahmut Ozsahin
Objective: Primary uterine leiomyosarcomas (ULMS) are rare, and the optimal treatment is controversial. We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS. Methods: We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network (RCN). Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS, aged 18-80 years, complete International Federation of Gynecology and Obstetrics (FIGO) stage information, complete information on treatment, and a minimum follow-up of 6 months...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353973/prognostic-evaluation-of-postoperative-adjuvant-therapy-for-operable-cervical-cancer-10-years-experience-of-national-cancer-center-in-china
#10
Tong Shu, Dan Zhao, Bin Li, Yating Wang, Shuanghuan Liu, Pingping Li, Jing Zuo, Ping Bai, Rong Zhang, Lingying Wu
Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer. Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics (FIGO) Ib-IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed. The median follow-up was 70 months...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353972/accuracy-of-triage-strategies-for-human-papillomavirus-dna-positive-women-in-low-resource-settings-a-cross-sectional-study-in-china
#11
Margaret Wang, Shangying Hu, Shuang Zhao, Wenhua Zhang, Qinjing Pan, Xun Zhang, Feng Chen, Jinxiu Han, Junfei Ma, Jennifer S Smith, Youlin Qiao, Caihong Zhou, Fanghui Zhao
Objective: CareHPV is a human papillomavirus (HPV) DNA test for low-resource settings (LRS). This study assesses optimum triage strategies for careHPV-positive women in LRS. Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid (VIA), liquid-based cytology and HPV testing by physician- and self-collected careHPV, and physician-collected Hybrid Capture 2 (HC2). Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353971/trends-in-geographical-disparities-for-cervical-cancer-mortality-in-china-from-1973-to-2013-a-subnational-spatio-temporal-study
#12
Changfa Xia, Chao Ding, Rongshou Zheng, Siwei Zhang, Hongmei Zeng, Jinfeng Wang, Yilan Liao, Ningxu Zhang, Zhixun Yang, Wanqing Chen
Objective: This study was designed to explore the time trends in geographical variations of cervical cancer mortality in mainland China over the period 1973 to 2013, to provide subnational spatio-temporal patterns for targeted promotion of human papillomavirus vaccine in China. Methods: Data were extracted from three national retrospective death surveys and cancer registry. The rate ratio (RR) was estimated for the aggregated data for seven geographical regions using generalized linear models to evaluate time trends in geographical disparities of cervical cancer mortality...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353970/trends-of-incidence-rate-and-age-at-diagnosis-for-cervical-cancer-in-china-from-2000-to-2014
#13
Xueting Li, Rongshou Zheng, Xuemei Li, Haibin Shan, Qi Wu, Yan Wang, Wanqing Chen
Objective: To analyze the trends of incidence rate and age at diagnosis for cervical cancer incidence in China using population-based cancer registration data from 2000 to 2014. Methods: Data were from National Central Cancer Registry of China. Crude incidence rates (CIRs), age-specific incidence rate, age-standardized incidence rates (ASIRs), age percentage distribution, standardized age percentage distribution, mean age at diagnosis and standardized mean age at diagnosis for cervical cancer in all areas of China, urban China and rural China were calculated separately...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29353969/incidence-and-mortality-of-cervical-cancer-in-china-2013
#14
Bingbing Song, Chao Ding, Wangyang Chen, Huixin Sun, Maoxiang Zhang, Wanqing Chen
Objective: Estimating the incidence and mortality rate of cervical cancer became necessary to establish prevention measures and healthy policies. The aim of this study was to estimate the updated incidence and mortality rate of cervical cancer in 2013 in China. Methods: According to the evaluation criteria developed by the National Central Cancer Registry of China, the data submitted from 255 cancer registries met the required standards in 2013. Cervical cancer cases were retrieved from the national database and combined with the 2013 national population data...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29142466/higher-pd-1-expression-concurrent-with-exhausted-cd8-t-cells-in-patients-with-de-novo-acute-myeloid-leukemia
#15
Jiaxiong Tan, Shaohua Chen, Yuhong Lu, Danlin Yao, Ling Xu, Yikai Zhang, Lijian Yang, Jie Chen, Jing Lai, Zhi Yu, Kanger Zhu, Yangqiu Li
Objective: To investigate the association between the T cell inhibitory receptor programmed death 1 (PD-1) and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia (AML) and AML in complete remission (CR). Methods: Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+, CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed, untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29142465/efficacy-of-vinorelbine-combined-with-low-dose-methotrexate-for-treatment-of-inoperable-desmoid-tumor-and-prognostic-factor-analysis
#16
Shu Li, Zhengfu Fan, Zhiwei Fang, Jiayong Liu, Chujie Bai, Ruifeng Xue, Lu Zhang, Tian Gao
Objective: To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor (DT) and analyze the prognostic factors. Methods: From November 2008 to April 2016, 71 patients of inoperable DT were treated with vinorelbine and low-dose methotrexate in the Department of Bone and Soft Tissue Tumors, Peking University Cancer Hospital & Institute, and enrolled in this retrospective study. The chemotherapy duration is one year. The efficacy of chemotherapy and the prognosis were observed...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29142464/bmpr2-and-hif1-%C3%AE-overexpression-in-resected-osteosarcoma-correlates-with-distant-metastasis-and-patient-survival
#17
Shidong Wang, Tingting Ren, Yi Huang, Xing Bao, Kunkun Sun, Danhua Shen, Wei Guo
Objective: Bone morphogenetic protein receptor 2 (BMPR2) and hypoxia-inducible factor 1-α (HIF1-α) existed abnormal expression in several types of cancer. However, their expressions and related roles in osteosarcoma are largely unknown. Methods: To investigate the clinical significance of BMPR2 and HIF1-α in osteosarcoma, we analyzed their expression levels in 103 osteosarcoma specimens by immunochemistry. Meanwhile, we conducted a follow-up to examine the metastatic behavior and overall survival (OS) of osteosarcoma patients...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29142463/management-of-extramedullary-plasmacytoma-role-of-radiotherapy-and-prognostic-factor-analysis-in-55-patients
#18
Ge Wen, Weihu Wang, Yujing Zhang, Shaoqing Niu, Qiwen Li, Yexiong Li
Objective: To investigate potential prognostic factors affecting patient outcomes and to evaluate the optimal methods and effects of radiotherapy (RT) in the management of extramedullary plasmacytoma (EMP). Methods: Data from 55 patients with EMP between November 1999 and August 2015 were collected. The median age was 51 (range, 22-77) years. The median tumor size was 3.5 (range, 1.0-15.0) cm. The median applied dose was 50.0 (range, 30.0-70.0) Gy. Thirty-nine patients (70...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29142462/a-national-report-from-china-liver-transplant-registry-steroid-avoidance-after-liver-transplantation-for-hepatocellular-carcinoma
#19
Qiang Wei, Feng Gao, Runzhou Zhuang, Qi Ling, Qinghong Ke, Jian Wu, Tian Shen, Mangli Zhang, Min Zhang, Xiao Xu, Shusen Zheng
Objective: We aimed to evaluate the efficacy and safety of steroid-free immunosuppression after liver transplantation (LT) for hepatocellular carcinoma (HCC). Methods: We retrospectively analyzed HCC recipients without steroids after LT (SF group, n=368) based on the China Liver Transplant Registry (CLTR) database. These recipients were matched 1:2 with patients using steroids (S group, n=736) for the same period after LT for HCC, according to propensity scores...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29142461/analysis-of-inpatient-payments-of-breast-cancer-patients-with-different-medical-insurance-coverages-in-china-mainland-in-2011-2015
#20
Rui Li, Liang Zhang, Jinxia Yang, Yue Cai, Wanqing Chen, Lan Lan, Ming Xue, Qun Meng
Objective: An understanding of the levels and trends of medical cost is made for breast cancer patients with different medical insurance coverages in China (mainland), in an attempt to offer a clue to further control the costs. Methods: The inpatient payments of 9,716,180 breast cancer patients spent in medical institutions of different types and grades during 2011-2015 were collected from the inpatient medical record home page (IMRHP) dataset. The data were then processed with SAS (Version 9...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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