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Colloids and Surfaces. B, Biointerfaces

Bi Wang, Liang Zhao, Weiwei Zhu, Liming Fang, Fuzeng Ren
Magnesium alloys are promising candidates for load-bearing orthopedic implants due to their biodegradability and mechanical resemblance to natural bone tissue. However, the high degradation rate and the risk of implant-associated infections pose grand challenges for their clinical applications. Herein, we developed a nano-multilayered coating strategy through polydopamine and chitosan assisted layer-by-layer assembly of osteoinductive carbonated apatite and antibacterial sliver nanoparticles on the surface of AZ31 magnesium alloys...
June 17, 2017: Colloids and Surfaces. B, Biointerfaces
Ji Hee Kang, Kyoung-Ran Kim, Hyukjin Lee, Dae-Ro Ahn, Young Tag Ko
Deoxyribonucleic acid (DNA) is a versatile material with high applicability and inherent biocompatibility. L-DNA, the perfect mirror form of the naturally occurring D-DNA, has been used in DNA nanotechnology. It has thermodynamically identical properties to D-DNA, is capable of self-assembly and bio-orthogonal base-pairing, and is resistant to nuclease activity. We previously constructed an L-DNA tetrahedron (L-Td) and found that this nanostructure has remarkably higher capacity for cell penetration than its natural counterpart (D-Td)...
June 16, 2017: Colloids and Surfaces. B, Biointerfaces
Cristina Pavan, Francesco Turci, Maura Tomatis, Mara Ghiazza, Dominique Lison, Bice Fubini
Among the physico-chemical features responsible for the so-called "variability of quartz hazard", a key role has been assigned to the silica surface charge, evaluated by means of ζ potential measurement. The ζ potential of silica describes the protonation state of silanols which, in turn, determine interactions with cell membranes. To gain a molecular understanding of the role of silanols in silica pathogenicity, we conducted a systematic investigation of the variation of the ζ potential as a function of pH (ζ plot titration curve) on a large set of respirable quartz particles with different levels of metal contaminants...
June 13, 2017: Colloids and Surfaces. B, Biointerfaces
Tara M Gallagher, John N Marafino, Brenden K Wimbish, Brandi Volkers, Gabriel Fitzgerald, Kristin McKenna, Jason Floyd, Nicholas T Minahan, Brenna Walsh, Kirstie Thompson, David Bruno, Monica Paneru, Sybelle Djikeng, Stephanie Masters, Suma Haji, Kyle Seifert, Kevin L Caran
Hydra amphiphiles mimic the morphology of the mythical multi-headed creatures for which they are named. Likewise, when faced with a pathogenic bacterium, some hydra derivatives are as destructive as their fabled counterparts were to their adversaries. This report focuses on eight new tricephalic (triple-headed), single-tailed amphiphiles. Each amphiphile has a mesitylene (1,3,5-trimethylbenzene) core, two benzylic trimethylammonium groups and one dimethylalkylammonium group with a linear hydrophobe ranging from short (C8H17) to ultralong (C22H45)...
June 10, 2017: Colloids and Surfaces. B, Biointerfaces
L Bromberg, X Liu, I Wang, S Smith, K Schwicker, Z Eller, G K German
The outermost layer of human skin, or stratum corneum, acts as a protective barrier between underlying living tissue and the external environment. The wettability of this tissue layer can influence spreading of chemicals and the adhesion of pathogenic microorganisms. We show in this article that the wettability of isolated human stratum corneum can be controlled through treatment with solutions of the anionic surfactant, sodium lauryl sulfate, buffered to different pH values. Relative to control treatments with the buffer solution alone, surfactant solution treatments under acidic conditions cause delipidated stratum corneum to become more hydrophobic...
June 9, 2017: Colloids and Surfaces. B, Biointerfaces
Di Yin, Gangwei Xu, Mengyuan Wang, Mingwu Shen, Tiegang Xu, Xiaoyue Zhu, Xiangyang Shi
We present a facile particle-based cell manipulation method using acoustic radiation forces. In this work, we selected several representative particles including poly(lactic-co-glycolic acid) (PLGA) microspheres, silica-coated magnetic microbeads, polydimethylsiloxane (PDMS) microspheres and investigated the responses of these particle systems to ultrasonic standing waves (USWs) in a microfluidic chip. We show that depending on the nature (positive or negative acoustic contrast factors) of the particles, these particle systems display different alignment behaviors along the microfluidic channel under USWs...
June 9, 2017: Colloids and Surfaces. B, Biointerfaces
Mingfang Wang, Jinyu Wang, Bingcheng Li, Lingxin Meng, Zhaoxing Tian
Co-delivery of chemotherapy drugs and siRNA for cancer therapy has achieved remarkable results according to synergistic/combined antitumor effects, and is recognized as a promising therapeutic modality. However, little attention has been paid to the extremely complex mechanisms of chemotherapy drug-siRNA pairs during co-delivery process. Proper selection of chemotherapy drug-siRNA pairs is beneficial for achieving desirable cancer therapeutic effects. Exploring the inherent principles during chemotherapy drug-siRNA pair selection for co-delivery would greatly enhanced therapeutic efficiency...
June 8, 2017: Colloids and Surfaces. B, Biointerfaces
Yekaterina Shapira, Victor Multanen, Gene Whyman, Yelena Bormashenko, Gilad Chaniel, Zahava Barkay, Edward Bormashenko
Cold radiofrequency plasma treatment modified wetting and floating regimes of pepper seeds. The wetting regime of plasma-treated seeds was switched from the Wenzel-like partial wetting to the complete wetting. No hydrophobic recovery following the plasma treatment was registered. Environmental scanning electron microscopy of the fine structure of the (three-phase) triple line observed with virgin and plasma-treated seeds is reported. Plasma treatment promoted rapid sinking of pepper seeds placed on the water/air interface...
June 7, 2017: Colloids and Surfaces. B, Biointerfaces
Ni He, Tingyu Wu, Jingjing Jiang, Xuwei Long, Bing Shao, Qin Meng
Rhamnolipids are the most promising biosurfactants, have widespread applications in many fields. However, low yield and productivity in fermentation caused a high production cost and thus prohibited the bulk applications of rhamnolipids in industry. In this study, a sequential fed-batch fermentation process with fill-and-draw operation was developed to improve rhamnolipids production. By utilizing this strategy, the total produced rhamnolipids reached over 150g/L, had a 163% and 102% increase over the traditional batch and fed-batch processes, respectively...
June 7, 2017: Colloids and Surfaces. B, Biointerfaces
Song Zhao, Wei Su, Vishva Shah, Divia Hobson, Lara Yildirimer, Kelvin W K Yeung, Jinzhong Zhao, Wenguo Cui, Xin Zhao
Tearing of the rotator cuff commonly occurs as among one of the most frequently experienced tendon disorders. While treatment typically involves surgical repair, failure rates to achieve or sustain healing range from 20 to 90%. The insufficient capacity to recover damaged tendon to heal to the bone, especially at the enthesis, is primarily responsible for the failure rates reported. Various types of biomaterials with special structures have been developed to improve tendon-bone healing and tendon regeneration, and have received considerable attention for replacement, reconstruction, or reinforcement of tendon defects...
June 6, 2017: Colloids and Surfaces. B, Biointerfaces
Tom Felbeck, Sebastian Moss, Alexandre M P Botas, Marina M Lezhnina, Rute A S Ferreira, Luís D Carlos, Ulrich H Kynast
The investigation of nanoparticles and their interaction with bio-macromolecules have become an important issue; the widely discussed protein corona around nanoparticles and their biological fate in general have drawn particular attention. Here, we focus on nanoclay dispersions and the use of solvatochromic fluorescent dyes (Dansyl and Coumarin 153) for monitoring the interaction with two model proteins, bovine serum albumin and β-lactoglobulin. On one hand, these dyes are poorly emissive in water, but experience a boost in their fluorescence when adsorbed into the hydrophobic domains of proteins...
June 6, 2017: Colloids and Surfaces. B, Biointerfaces
Nauman Khalid, Gaofeng Shu, Isao Kobayashi, Mitsutoshi Nakajima, Colin J Barrow
The study used straight-through microchannel emulsification (MCE) to encapsulate different extracts of astaxanthin (AXT) in oil-in-water (O/W) emulsion droplets. We used silicon microchannel plates (WMS 11-1) containing 13,752 discrete 10×104μm microslots, connected to a circular microhole with a diameter of 10μm. Two different AXT extracts (AstaReal (AR) and Zenthin(®) (ZR)) based upon concentration and without purification was used as encapsulants in the dispersed phase, while different emulsifiers (1% (w/w) SDS, ML-750, MO-7S, Na-Cs and ML) with different stabilizing mechanisms were used as the continuous phase...
June 4, 2017: Colloids and Surfaces. B, Biointerfaces
Zhi-Min Chang, Zheng Wang, Meng-Meng Lu, Dan Shao, Juan Yue, Dian Yang, Ming-Qiang Li, Wen-Fei Dong
In this study, we exploited a one-pot method to fabricate cetyltrimethylammonium bromide (CTAB)-loaded Janus silver mesoporous silica nanoparticles (Janus Ag-MSNs@CTAB). These bullet-like nanoparticles had a silver head (80nm in diameter) attached to a mesoporous silica stick (200-300nm in length). The CTAB-loaded nanobullets exhibited a marked affinity for the bacterial cell surface and the simultaneously sustained release behavior of CTAB and silver ions. The minimum inhibitory concentrations (MIC) of Janus Ag-MSNs@CTAB were determined to be 10μg/mL and 20μg/mL for E...
June 4, 2017: Colloids and Surfaces. B, Biointerfaces
Hui Liu, Kai Wang, Cangjie Yang, Shuo Huang, Mingfeng Wang
Polymeric micelles loaded with multiple therapeutic modalities are important to overcome challenges such as drug resistance and improve the therapeutic efficacy. Here we report a new polymer micellar drug carrier that integrates chemotherapy and photothermal therapy in a single platform. Specifically, a narrow bandgap poly(dithienyl-diketopyrrolopyrrole) (PDPP) polymer was encapsulated together with a model anticancer drug doxorubicin (DOX) in the hydrophobic cores of polymeric micelles formed by Pluronic F127, an amphiphilic poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer...
June 3, 2017: Colloids and Surfaces. B, Biointerfaces
J C Soares, Tcb Pereira, K M Costa, T Maraschin, N R Basso, M R Bogo
Although graphene oxide (GO), a nanomaterial with hexagonal planar layer, has been widely studied due to its applications in neurobiology that include drug delivery and tissue engineering, additional studies to assess its potential toxic effects are still needed. Thus, this study evaluated the effects of GO exposure (at 5, 10, 50 or 100mg/L) during six consecutive days on mortality, hatching, spontaneous movement, heart rate, morphology, locomotion behavior, acetylcholinesterase (AChE) activity, dopamine levels and relative gene expression of developmental neurology-related genes using zebrafish larvae...
June 3, 2017: Colloids and Surfaces. B, Biointerfaces
Muslim Raza, Yang Jiang, Yun Wei, Aftab Ahmad, Ajmal Khan, Yuan Qipeng
The study of molecular interactions of drug-protein are extremely important from the biological aspect in all living organisms, and therefore such type of investigation hold a tremendous significance in rational drug design and discovery. In the present study, the molecular interactions between paromomycin (PAR) and human serum albumin (HSA) have been studied by different biophysical techniques and validated by in-silico approaches. The results obtained from Ultraviolet-visible spectroscopy (UV) and Fourier transform infrared spectroscopy (FT-IR) demonstrated a remarkable change upon the complexation of PAR with HSA...
June 3, 2017: Colloids and Surfaces. B, Biointerfaces
Hye Young Nam, Kyung Hyun Min, Da Eun Kim, Jeong Ryul Choi, Hong Jae Lee, Sang Cheon Lee
We developed a calcium phosphate (CaP)-assembled polymer nanocarrier for intracellular doxorubicin (DOX) delivery based on a mussel-inspired mineralization approach. A DOX-loaded core-shell polymer nanoparticle (DOX-NP) consisting of a poly(3,4-dihydroxy-l-phenylalanine) (PDOPA) core and a poly (ethylene glycol) (PEG) shell was utilized as a nanotemplate for CaP mineralization. The mean hydrodynamic diameter of the DOX-loaded CaP-mineralized polymer nanoparticles (DOX-CaP-NPs) was 154.3nm. Energy-dispersive X-ray spectroscopy confirmed that the DOX-CaP-NPs contained substantial amounts of Ca and P, elements found only in the CaP mineral...
June 3, 2017: Colloids and Surfaces. B, Biointerfaces
Jordan T Pepper, Priti Maheshwari, François Eudes
Microspores are the pre-gametophyte stage of pollen, and have proven to be a successful tissue culture material for the production of doubled haploid plants. Microspore culture has also been used as a platform for the production of transgenic plants. The use of cell-penetrating peptides (CPPs) as transfection agents in microspores has been previously demonstrated, but at low efficiencies. Here, the pH dependent adsorption of the cationic CPP Tat2 to the sporopollenin surface of the microspore (the exine) has been explored using electrophoretic light scattering (ELS)...
June 3, 2017: Colloids and Surfaces. B, Biointerfaces
Claire Valotteau, Ibrahim M Banat, Christopher A Mitchell, Helen Lydon, Roger Marchant, Florence Babonneau, Claire-Marie Pradier, Niki Baccile, Vincent Humblot
Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties. We show that they can be used to develop biocidal monolayers against Listeria ivanovii, a Gram-positive bacterium. The present work points out the dependence between the surface density and the antibacterial activity of grafted sophorolipids. It also emphasizes the broad spectrum of activity of these coatings, demonstrating their potential against both Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis, Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhymurium)...
June 2, 2017: Colloids and Surfaces. B, Biointerfaces
L Tosheva, S Belkhair, M Gackowski, S Malic, N Al-Shanti, J Verran
A semi-quantitative screening method was used to compare the killing efficacy of Ag zeolites against bacteria and yeast as a function of the zeolite type, crystal size and concentration. The method, which substantially reduced labor, consumables and waste and provided an excellent preliminary screen, was further validated by quantitative plate count experiments. Two pairs of zeolite X and zeolite beta with different sizes (ca. 200nm and 2μm for zeolite X and ca. 250 and 500nm for zeolite beta) were tested against Escherichia coli (E...
June 2, 2017: Colloids and Surfaces. B, Biointerfaces
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