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Colloids and Surfaces. B, Biointerfaces

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https://www.readbyqxmd.com/read/28208061/dual-drug-release-from-hydrogels-covalently-containing-polymeric-micelles-that-possess-different-drug-release-properties
#1
Mari Murata, Yusuke Uchida, Taku Takami, Tomoki Ito, Ryosuke Anzai, Seiichi Sonotaki, Yoshihiko Murakami
In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations to evaluate the profiles depicting the release of two compounds, rhodamine B and auramine O, from either polymeric micelles or hydrogels...
February 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28208062/nano-suspension-coating-as-a-technique-to-modulate-the-drug-release-from-controlled-porosity-osmotic-pumps-for-a-soluble-agent
#2
Leila Azharshekoufeh Bahari, Yousef Javadzadeh, Mohammad Barzegar Jalali, Peyvand Johari, Ali Nokhodchi, Javad Shokri
In controlled porosity osmotic pumps (CPOP), usually finding a single solvent with a capability to dissolve both film former (hydrophobic) and pore former (hydrophilic) is extremely challenging. Therefore, the aim of the present investigation was to tackle the issue associated with controlled porosity osmotic pump (CPOP) system using nano-suspension coating method. In the present study 4-Amino pyridine was used as a highly water soluble drug. In this method, a hydrophilic pore former (sucrose or mannitol) in nano range was suspended in polymeric coating solution using ball-mill...
February 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28189036/corrigendum-to-polyethylenimine-polyacrylic-acid-nanocomposites-type-of-bonding-does-influence-the-gene-transfer-efficacy-and-cytotoxicity-colloids-surf-b-biointerfaces-140-2016-117-20
#3
S K Tripathi, Z Ahmadi, K C Gupta, P Kumar
No abstract text is available yet for this article.
February 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28187379/novel-doxorubicin-loaded-pegylated-cuprous-telluride-nanocrystals-for-combined-photothermal-chemo-cancer-treatment
#4
Xianwen Wang, Yan Ma, Huajian Chen, Xiaoyi Wu, Haisheng Qian, Xianzhu Yang, Zhengbao Zha
Recently, combined photothermal-chemo therapy has attracted great attention due to its enhanced anti-tumor efficiency via synergistic effects. Herein, PEGylated cuprous telluride nanocrystals (PEGylated Cu2Te NCs) were developed as novel drug nanocarriers for combined photothermal-chemo treatment of cancer cells. PEGylated Cu2Te NCs were fabricated through a simple two-step process, comprised of hot injection and thin-film hydration. The as-prepared PEGylated Cu2Te NCs (average diameter of 5.21±1.05nm) showed a noticeable photothermal conversion efficiency of 33...
February 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28192714/design-and-synthesis-of-temperature-responsive-polymer-silica-hybrid-nanoparticles-and-application-to-thermally-controlled-cellular-uptake
#5
Yuki Hiruta, Ryo Nemoto, Hideko Kanazawa
This study reports the development of temperature-responsive polymer/silica hybrid nanoparticles and their application to temperature-dependent intracellular uptake of hydrophobic encapsulated fluorescence molecules. Amphiphilic diblock copolymer comprising a temperature-responsive segment, poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) [P(NIPAAm-co-DMAAm)] and a trimethyoxysilyl-containing hydrophobic segment was synthesized (PBM-b-ND); this amphiphilic diblock copolymer self-assembled in an aqueous solution, and temperature-responsive polymer/silica hybrid fluorescence nanoparticles were fabricated via a base-catalyzed sol-gel process...
February 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28187381/inherently-fluorescent-polystyrene-microspheres-for-coating-sensing-and-cellular-imaging
#6
Jian-Bo Qu, Yu-Liang Xu, Yu Liu, Yanan Wang, Yuanhong Sui, Jian-Guo Liu, Xiaojuan Wang
Commercially available polystyrene (PS) fluorescent microspheres are widely used in biological field for tracing, in vivo imaging and calibration of flow cytometry, among other applications. However, these particles do suffer from some drawbacks such as the leakage and photobleaching of organic dyes within them. In the present study, inherently fluorescent properties of PS based microspheres have been explored for the first time. Here we find that a simple chloromethylation reaction endows the polystyrene particles with inherent fluorescence without any subsequent conjugation of an external fluorophore...
February 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28187380/biomimetic-nanoassemblies-of-1-o-octodecyl-2-conjugated-linoleoyl-sn-glycero-3-phosphatidyl-gemcitabine-with-phospholipase-a2-triggered-degradation-for-the-treatment-of-cancer
#7
Jing Zuo, Li Tong, Lina Du, Ming Yang, Yiguang Jin
Phospholipids are important biomolecules with strong self-assembling ability to form biomembranes or liposomes. However, biomimetic prodrugs of phospholipids are not well known, including their self-assembling behavior at the air/water interface or in aqueous media. Here we design and prepare a biomimetic phospholipid-like amphiphilic prodrug, 1-O-octodecyl-2-conjugated linoleoyl-sn-glycero-3-phosphatidyl gemcitabine (OLGPG). After spreading at the air/water interface, it formed Langmuir monolayers. Stable nanoassemblies were obtained based on molecular self-assembly after OLGPG was injected in water...
February 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28196351/fabrication-and-functional-attributes-of-lipidic-nanoconstructs-of-lycopene-an-innovative-endeavour-for-enhanced-cytotoxicity-in-mcf-7-breast-cancer-cells
#8
Ashay Jain, Gajanand Sharma, Varun Kushwah, Kanika Thakur, Gargi Ghoshal, Bhupinder Singh, Sanyog Jain, U S Shivhare, O P Katare
The present study investigates the anticancer efficacy of lycopene loaded lipidic nanostructured particles. With a homogenization-evaporation technique, lycopene loaded solid lipid nanoparticles (LYC-SLNs) were fabricated with different ratios of biocompatible viz. compritol ATO 888 and gelucire, and evaluated for their micromeretics properties, in vitro release, in vitro cytotoxicity, cellular uptake and apoptosis induced in MCF-7 cells. Effects of anticancer potential of LYC-SLNs on the efficacy of methotrexate (MTX), a well-established anticancer agent, was evaluated thereafter...
February 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28192713/a-stable-nanoplatform-for-antitumor-activity-using-peg-pll-pla-triblock-co-polyelectrolyte
#9
Chaemin Lim, Taehoon Sim, Ngoc Ha Hoang, Kyung Taek Oh
Polyelectrolyte has been proposed as an efficient approach for various types of drug formulations. However, one drawback of using the conventional polyelectrolyte for drug delivery is its dissociation in in vivo conditions by counter ions due to the lack of self-assembling aggregation force. In this study, we reported a stable nanoplatform based on triblock co-polyelectrolyte composed of a poly(ethylene glycol), poly(l-lysine), and poly(lactic acid). These co-polyelectrolytes formed stable aggregates through the hydrophobic interaction of PLA and showed consistent particle sizes under a high salt concentration...
February 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28167455/dendrimer-protein-interactions-versus-dendrimer-based-nanomedicine
#10
REVIEW
Dzmitry Shcharbin, Natallia Shcharbina, Volha Dzmitruk, Elzbieta Pedziwiatr-Werbicka, Maksim Ionov, Serge Mignani, F Javier de la Mata, Rafael Gómez, Maria Angeles Muñoz-Fernández, Jean-Pierre Majoral, Maria Bryszewska
Dendrimers are hyperbranched polymers belonging to the huge class of nanomedical devices. Their wide application in biology and medicine requires understanding of the fundamental mechanisms of their interactions with biological systems. Summarizing, electrostatic force plays the predominant role in dendrimer-protein interactions, especially with charged dendrimers. Other kinds of interactions have been proven, such as H-bonding, van der Waals forces, and even hydrophobic interactions. These interactions depend on the characteristics of both participants: flexibility and surface charge of a dendrimer, rigidity of protein structure and the localization of charged amino acids at its surface...
January 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28171795/multifunctional-silver-nanocluster-hybrid-oligonucleotide-vehicle-for-cell-imaging-and-microrna-targeted-gene-silencing
#11
Hau-Yun Chen, Karunya Albert, Cheng-Che Wen, Pei-Ying Hsieh, Sih-Yu Chen, Nei-Chung Huang, Shen-Chuan Lo, Jen-Kun Chen, Hsin-Yun Hsu
Novel therapeutics is urgently needed to prevent cancer-related deaths. MicroRNAs that act as tumor suppressors have been recognized as a next-generation tumor therapy, and the restoration of tumor-suppressive microRNAs using microRNA replacements or mimics may be a less toxic, more effective strategy due to fewer off-target effects. Here, we designed the novel multifunctional oligonucleotide nanocarrier complex composed of a tumor-targeting aptamer sequence specific to mucin 1 (MUC1), poly-cytosine region for fluorescent silver nanocluster (AgNC) synthesis, and complimentary sequence for microRNA miR-34a loading...
January 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28189097/thermo-responsive-nanoarrays-of-silver-nanoparticle-silicate-nanoplatelet-and-pnipaam-for-the-antimicrobial-applications
#12
Hsiao-Chu Lin, Yu-An Su, Ting-Yu Liu, Yu-Jane Sheng, Jiang-Jen Lin
The ternary nanohybrids of silver nanoparticles (AgNPs) in combination with silicate nanoplatelets (NSP) and thermally sensitive poly(N-isopropylacrylamide) (PNiPAAm) were fabricated for antibacterial applications. PNiPAAm were chemically grafted on the NSP by atom-transfer radical polymerization (ATRP) via polymerizing N-isopropylacrylamide monomers with sol-gel linkers (BBTES). The nanoparticles of AgNPs then were adsorbed on NSP-PNiPAAm nanosheets through in situ reduction reaction of AgNO3 in aqueous dispersion...
January 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28178611/coaxial-electrospinning-multicomponent-functional-controlled-release-vascular-graft-optimization-of-graft-properties
#13
Anlin Yin, Rifang Luo, Jiukai Li, Xiumei Mo, Yunbing Wang, Xingdong Zhang
Small diameter vascular grafts possessing desirable biocompatibility and suitable mechanical properties have become an urgent clinic demand. Herein, heparin loaded fibrous grafts of collagen/chitosan/poly(l-lactic acid-co-ε-caprolactone) (PLCL) were successfully fabricated via coaxial electrospinning. By controlling the concentration of heparin and the ratio of collagen/chitosan/PLCL, most grafts had the heparin encapsulation efficiency higher than 70%, and the heparin presented sustained release for more than 45 days...
January 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28152461/mn-containing-titanium-surface-with-favorable-osteogenic-and-antimicrobial-functions-synthesized-by-piii-d
#14
Le Yu, Yaxin Tian, Yuqin Qiao, Xuanyong Liu
Reasonable incorporation of manganese into titanium is believed to be able to enhance the osteogenic and antibacterial activities of orthopedic implants. However, it is still a challenge to compromise Mn-induced cytotoxicity and better develop its biocompatibility and antimicrobial ability. To pinpoint this issue, a stable Mn ion release platform was created on Ti using plasma immersion ion implantation and deposition (PIII&D) technique. Compared with as-etched titanium, as a result, promoted antibacterial abilities against gram-negative bacteria species and enhanced osteogenic-related gene expressions on rBMMSC were observed on Mn-containing sample...
January 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28157647/redox-responsive-albumin-autogenic-nanoparticles-for-the-delivery-of-cancer-drugs
#15
S Thirupathi Kumara Raja, T Prakash, A Gnanamani
The present study explores preparation and characterization of redox sensitive albumin autogenic nanoparticles (ANPs) for drug delivery applications. Human serum albumin nanoparticles are prepared by desolvation method. The particles are stabilized through self-crosslinking and no external stabilizers are involved in the preparation. ANPs are then subjected to Camptothecin (CPT) drug loading. Experiments on in vitro and in vivo release profile, cytotoxic and cytocompatability, hemocompatability, blood clearance, tracking and bio imaging are studied in detail...
January 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28152462/a-novel-ionic-amphiphilic-chitosan-derivative-as-a-stabilizer-of-nanoemulsions-improvement-of-antimicrobial-activity-of-cymbopogon-citratus-essential-oil
#16
Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Donatella Usai, Ioannis Liakos, Alice Garzoni, Maura Fiamma, Stefania Zanetti, Athanassia Athanassiou, Carla Caramella, Franca Ferrari
Amphiphilic chitosans have been recently proposed to improve delivery of poorly soluble drugs. In the present paper a derivative obtained by ionic interaction between chitosan and oleic acid was for the first time studied to physically stabilize o/w nanoemulsions of an antimicrobial essential oil, Cymbopogon citratus (Lemongrass), in a low energy and mild conditions emulsification process. The novel combination of spontaneous emulsification process with chitosan oleate amphiphilic properties resulted in a stable dispersion of a few hundred nanometer droplets...
January 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28135680/biofunctional-polyethylene-glycol-coatings-on-titanium-an-in-vitro-based-comparison-of-functionalization-methods
#17
Judit Buxadera-Palomero, Cristina Calvo, Sergi Torrent-Camarero, F Javier Gil, Carlos Mas-Moruno, Cristina Canal, Daniel Rodríguez
Three methods for the production of Polyethylene glycol (PEG) coatings on titanium are compared, i.e. plasma polymerization, electrodeposition and silanization. The compared deposition methods presented similar wettability (hydrophilic coatings), chemical composition assessed by XPS and thickness around 1nm. The coatings lowered albumin adsorption and presented a decreased fibroblast, Streptococcus sanguinis and Lactobacillus salivarius adhesion. Immobilization of a cell adhesion peptide (RGD) presented a higher fibroblast adhesion and no alteration of the bacterial adhesion, giving three methods for the biofunctionalization of titanium for dental implants...
January 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28131959/yap-mediated-mechanotransduction-regulates-osteogenic-and-adipogenic-differentiation-of-bmscs-on-hierarchical-structure
#18
Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Xuebin Zheng, Qiming Fan, Tingting Tang
Hierarchical structure mimicking the natural bone microenvironment has been considered as a promising platform to regulate cell functions. We have previously fabricated hierarchical macropore/nanowire structure and evidence has shown that it can better manipulate the cytoskeleton status and osteogenic performance of osteoblasts. However, how cues of hierarchical structure are translated and ultimately linked to BMSC lineage commitment have still remained elusive, which hinders the accurate knowledge and further development of the hierarchical structure...
January 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28131958/poly-acrylic-acid-nanogel-as-a-substrate-for-cellulase-immobilization-for-hydrolysis-of-cellulose
#19
Ibrahim Nasser Ahmed, Ray Chang, Wei-Bor Tsai
Cellulase was adsorbed onto poly(acrylic acid), PAA, nanogel, that was fabricated via inverse-phase microemulsion polymerization. The PAA nanogel was around 150nm in diameter and enriched with carboxyl groups. The surface charge of PAA nanogel depended on the pHs of the environment and affected the adsorption of cellulase. The temperature stability of the immobilized cellulase was greatly enhanced in comparison to the free enzyme, especially at high temperature. At 80°C, the immobilized cellulase remained ∼75% of hydrolytic activity, in comparison to ∼55% for the free cellulase...
January 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28131960/three-species-biofilm-model-onto-plasma-treated-titanium-implant-surface
#20
Adaias O Matos, Antônio P Ricomini-Filho, Thamara Beline, Erika S Ogawa, Bárbara E Costa-Oliveira, Amanda B de Almeida, Francisco H Nociti Junior, Elidiane C Rangel, Nilson C da Cruz, Cortino Sukotjo, Mathew T Mathew, Valentim A R Barão
In this study, titanium (Ti) was modified with biofunctional and novel surface by micro-arc oxidation (MAO) and glow discharge plasma (GDP) and we tested the development of a three-species periodontopatogenic biofilm onto the treated commercially-pure titanium (cpTi) surfaces. Machined and sandblasted surfaces were used as control group. Several techniques for surface characterizations and monoculture on bone tissue cells were performed. A multispecies biofilm composed of Streptococcus sanguinis, Actinomyces naeslundii and Fusobacterium nucleatum was developed onto cpTi discs for 16...
January 21, 2017: Colloids and Surfaces. B, Biointerfaces
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