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Colloids and Surfaces. B, Biointerfaces

Junhong Chen, Mengting Li, Congling Yang, Xianzhen Yin, Ke Duan, Jianxin Wang, Bo Feng
Inflammatory response occurring between tissues and implants after implantation has attracted increasing attention because it can cause local tissue necrosis and even implant failure. Macrophages play a key role in all stages of inflammation. Pro-inflammatory (M1) and anti-inflammatory (M2) macrophages comprise two main phenotypes and the switch from M1 to M2 at specific time points is important for wound healing and tissue regeneration. Therefore, we hypothesized that biomaterial systems capable of facilitating macrophage phenotype switching should attenuate inflammation and enhance healing...
January 9, 2018: Colloids and Surfaces. B, Biointerfaces
Eepsita Priyadarshini, Kamla Rawat, Tulika Prasad, H B Bohidar
In the current study, we have investigated the toxicological effect of a novel hydrophilic nanoconjugate gold@carbon dot (Au@CD) and carbon dots (CDs) on the opportunistic fungal pathogen, Candida albicans. A homogenous experimental analysis was conducted for determining the toxicity of Au@CDs nanoconjugates of five different sizes ranging from 22 ± 2 to 35 ± 3 nm prepared using the carbon dots of mean hydrodynamic radius 12 ± 1 nm. The smallest size of nanoconjugate was synthesized using 0...
January 8, 2018: Colloids and Surfaces. B, Biointerfaces
Cheng Chi, Baohong Sun, Ninglin Zhou, Ming Zhang, Xiaohong Chu, Ping Yuan, Jian Shen
A novel catalyst system of Reverse Atom Transfer Radical Polymerization (RATRP) to prepare Polyurethane (PU) films modified by poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) was studied in this article. In this system, PU film was pretreated by LaCl3/CA ethanol solution to obtain a hydrated surface allowing more initiators to be immobilized on it. Moreover, complexes composed of silane coupling agent 3-chloropropyltrimethoxysilane (CPTM), chlorhexidine acetate (CA) and lanthanum(III) worked as ligands of copper ions as a whole during RATRP process...
January 8, 2018: Colloids and Surfaces. B, Biointerfaces
L M F C Torres, N A Braga, I P Gomes, M T Almeida, T L Santos, J P de Mesquita, L M da Silva, H R Martins, K C Kato, W T P Dos Santos, J M Resende, M C Pereira, M P Bemquerer, M A Rodrigues, R M Verly
The functionalization of alumina nanoparticles of specific morphology with antimicrobial peptides (AMP) can be a promising strategy for modeling medical devices and packaging materials for cosmetics, medicines or food, since the contamination by pathogens could be reduced. In this paper, we show the synthesis of a fibrous-like alumina nanobiostructure, as well as its functionalization with the peptide EAAA-BP100, an analog of the antimicrobial peptide BP100. The antibacterial activity of the obtained material against some bacterial strains is also investigated...
January 3, 2018: Colloids and Surfaces. B, Biointerfaces
Rajan Narayan, Tarun Agarwal, Debasish Mishra, Tapas Kumar Maiti, Sujata Mohanty
The cell and extracellular matrix (ECM) interactions play a very important role during angiogenesis. Remodeling of the extracellular matrix along with pro-angiogenic/anti-angiogenic factors, and matrix-degrading proteases, accounts for endothelial cell growth, migration, and tube formation. However, for studying angiogenesis, only limited and expensive biomaterials are available. Despite being biocompatible, inexpensive, and easy availability; the potential of goat tendon collagen (GTC) has never been explored for vascular tissue engineering applications...
January 2, 2018: Colloids and Surfaces. B, Biointerfaces
Tomoki Ito, Taku Takami, Yusuke Uchida, Yoshihiko Murakami
We prepared the "sheet-type hydrogel" (gel sheet), a sheet consisting of PEG-grafted chitosan and cross-linkable polymeric micelles, that were expected to be used for wound healing. We optimized the PEG-modification process, evaluated the strain-dependence of the gel's properties to obtain flexible gel sheets, and evaluated the drug-release properties of the gel sheets. Finally, we succeeded in observing that the release of the antibiotic tetracycline (TET) from the gel sheet in which TET existed only in the cross-linkers was lower than the release of TET from the sheet in which TET was dispersed in the polymer networks...
December 30, 2017: Colloids and Surfaces. B, Biointerfaces
Khan Behlol Ayaz Ahmed, Siva Bala Subramaniyan, Sanaulla Farisa Banu, Paramasivam Nithyanand, Anbazhagan Veerappan
In any therapeutic modality the usage of drug in high doses often leads to serious side-effects. Herein, we demonstrated a method to enhance the antibacterial efficacy of CuS NPs at lower concentration through interacting with jackfruit seed lectin, jacalin. Fluorescence quenching studies revealed that jacalin form complex with CuS NPs and the association constant was 1.91 × 104 M-1. Upon complex with jacalin, the bacterial minimum inhibitory concentration (MIC) of CuS NPs drastically decreases from 12...
December 30, 2017: Colloids and Surfaces. B, Biointerfaces
Jorge L Cholula-Díaz, Diana Lomelí-Marroquín, Bidhan Pramanick, Alfonso Nieto-Argüello, Luis A Cantú-Castillo, Hyundoo Hwang
Ascorbic acid (vitamin C) has an essential role in the human body mainly due to its antioxidant function. In this work, metallic silver nanoparticle (AgNP) colloids were used in SERS experiments to detect ascorbic acid in aqueous solution. The AgNPs were synthesized by a green method using potato starch as reducing and stabilizing agent, and water as the solvent. The optical properties of the yellowish as-synthesized silver colloids were characterized by UV-vis spectroscopy, in which besides a typical band at 410 nm related to the localized surface plasmon resonance of the silver nanoparticles, a shoulder band around 500 nm, due to silver nanoparticle cluster formation, is presented when relatively higher concentrations of starch are used in the synthesis...
December 29, 2017: Colloids and Surfaces. B, Biointerfaces
Dominik de Cassan, Steffen Sydow, Nadeschda Schmidt, Peter Behrens, Yvonne Roger, Andrea Hoffmann, Anna Lena Hoheisel, Birgit Glasmacher, Robert Hänsch, Henning Menzel
Electrospun poly(ε-caprolactone) (PCL) fiber mats are modified using a chitosan grafted with PCL (CS-g-PCL), to improve the biological performance and to enable further modifications. The graft copolymer is immobilized by the crystallization of the PCL grafts on the PCL fiber surface as binding mechanism. In this way, the surface of the fibers is covered with chitosan bearing cationic amino groups, which allow adsorption of oppositely charged nanoparticulate drug-delivery systems. The modification of the fiber mats and the attachment of the drug delivery systems are easy and scalable dip processes...
December 29, 2017: Colloids and Surfaces. B, Biointerfaces
Bingjie Zhou, Bozhen Wu, Jine Wang, Qihong Qian, Jing Wang, Hongbin Xu, Sun Yang, Pan Feng, Wu Chen, Yulin Li, Jia Jiang, Baosan Han
In order to overcome the multidrug resistance (MDR) of tumor cells, it is very important to develop nanocarriers which can effectively load drugs while releasing them in a sequential way. Herein, nanohybrids with such properties have been fabricated by a first loading of one anticancer drug onto a silicate nanodisk (Laponite (LP), 25 nm in diameter and 0.92 nm in thickness) and a subsequent assembly with a pH sensitive poly(N-vinylpyrrolidone) (PVP) as a protective layer, followed by a loading of with another anticancer drug...
December 29, 2017: Colloids and Surfaces. B, Biointerfaces
Nimisha Singh, Khushbu Patel, Suban K Sahoo, Rajender Kumar
Nitric oxide releasing superparamagnetic (Fe3O4-Au@NTHP) nanoparticles were synthesized by conjugation of human biomarker of nitric oxide, N-nitrosothioproline with iron oxide-gold (Fe3O4-Au) core shell nanoparticles. The structure and morphology of the prepared nanoparticles were confirmed by ATR-FTIR, HR-TEM, EDAX, XPS, DLS and VSM measurements. N-nitrosothioproline is a natural molecule and nontoxic to humans. Thus, the core shell nanoparticles prepared were highly biocompatible. The prepared Fe3O4-Au@NTHP nanoparticles also provided an excellent release of nitric oxide in dark and upon light irradiation for cancer treatment...
December 29, 2017: Colloids and Surfaces. B, Biointerfaces
Jingjing Luo, Haitao Zhang, Jiang Zhu, Xiaokang Cui, Junjiu Gao, Xin Wang, Jie Xiong
In the field of bone tissue engineering, an ideal three-dimensional (3-D) scaffold should not only structurally mimic the extracellular matrix (ECM) in large tissues but also mechanically support the bone healing process and provide biochemical cues to induce osteogenesis. In this study, we investigated the feasibility of functionalisation of scaffolds by coupling polyglutamate acid conjugated with BMP-2 peptide onto silk fibroin (SF)/polycaprolactone (PCL) (SF/PCL) blend nanofibers. The morphology, composition, and mineralisation, were confirmed by FE-SEM, XRD, and FT-IR spectroscopy...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
Xin Xu, Xiaofeng Wang, Wei Luo, Qihong Qian, Qian Li, Baosan Han, Yulin Li
In this report, biocompatible nanogels with multi cell-responsiveness (thermo-, pH- and reduction) were fabricated by in situ cross-linking of alginate (AG) using cystamine (Cys) as a cross-linker through an emulsion approach, in the presence of a thermosensitive polymer, poly(N-isopropylacrylamide) (PNIPAM). The AG/PNIPAM nanogels exhibited an abrupt swelling upon temperature increase from 37 to 25 °C under physiological conditions (497 ± 258 nm at 29 °C and 147 ± 48 nm at 37 °C). The nanogels were easily taken up by cancer cells at high temperature, where temperature variation could induce toxicity against cancer cells...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
Sunitha Chandran, Sachin J Shenoy, Suresh Babu S, Renjith P Nair, Varma H K, Annie John
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs)...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
Célio J C Fernandes, Fábio Bezerra, Marcel R Ferreira, Amanda F C Andrade, Thais Silva Pinto, Willian F Zambuzzi
Over the last several years, we have focused on the importance of intracellular signaling pathways in dynamically governing the biointerface between pre-osteoblast and surface of biomaterial. Thus, this study investigates the molecular hallmarks involved in the pre-osteoblast relationship with different topography considering Machined (Mc), Dual Acid-Etching (DAE), and nano hydroxyapatite-blasted (nHA) groups. There was substantial differences in topography of titanium surface, considering Atomic Force Microscopy and water contact angle (Mc = 81...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
Mehmet Odabaşı, Lokman Uzun, Gözde Baydemir, Neşe Hayat Aksoy, Ömür Acet, Demet Erdönmez
Molecularly imprinted polymers which have been extensively investigated as selective adsorbents were constructed using a template molecule during the polymerization to gain template-specific cavities. In this study, we prepared cholesterol imprinted poly(2-hydroxyethyl methacrylate-methacryloyamidotryptophan) (PHEMA-MTrp) particles embedded composite membranes. These membranes were characterized through elemental analysis, FTIR, SEM, swelling tests, and surface area measurements. Adsorption experiments were performed in a batch experimental set-up, and the adsorption medium was either a methanol or intestinal-mimicking solution...
December 27, 2017: Colloids and Surfaces. B, Biointerfaces
Liping Ouyang, Zhenjie Sun, Donghui Wang, Yuqin Qiao, Hongqin Zhu, Xiaohan Ma, Xuanyong Liu
It is important to fabricate an implant possessing environment sensitive drug delivery. In this work, the construction of 3D porous structure on polyetheretherketone (PEEK) surface and pH sensitive polymer, chitosan, was introduced. The smart release of doxorubicin can be realized on the 3D porous surface of PEEK loading chitosan. We give a feasible explanation for the effect of chitosan on smart drug release according to Henderson-Hasselbalch equation. Furthermore, the intracellular drug content of the cell cultured on the samples with highest chitosan is significantly higher at pH 4...
December 26, 2017: Colloids and Surfaces. B, Biointerfaces
Fataneh Karandish, James Froberg, Pawel Borowicz, John C Wilkinson, Yongki Choi, Sanku Mallik
Often cancer relapses after an initial response to chemotherapy because of the tumor's heterogeneity and the presence of progenitor stem cells, which can renew. To overcome drug resistance, metastasis, and relapse in cancer, a promising approach is the inhibition of cancer stemness. In this study, the expression of the neuropilin-1 receptor in both pancreatic and prostate cancer stem cells was identified and targeted with a stimuli-responsive, polymeric nanocarrier to deliver a stemness inhibitor (napabucasin) to cancer stem cells...
December 24, 2017: Colloids and Surfaces. B, Biointerfaces
Iryna Antal, Martina Koneracka, Martina Kubovcikova, Vlasta Zavisova, Iryna Khmara, Dasa Lucanska, Lenka Jelenska, Ivana Vidlickova, Miriam Zatovicova, Silvia Pastorekova, Nikola Bugarova, Matej Micusik, Maria Omastova, Peter Kopcansky
Amino-modified magnetic nanoparticles were prepared by direct chemisorption of biocompatible d,l-lysine (DLL) on electrostatically stabilized magnetic nanoparticles with the aim to bind specific antibodies (Ab) able to detect cancer cells. The magnetic nanoparticles prepared by coprecipitation were stabilized in an acidic medium. A full optimization study of amino modification performed by UV/Vis spectroscopy and Dynamic Light Scattering measurement (DLS) confirmed an optimal DLL/Fe3O4 weight ratio of 2. The sample was subjected to complex characterizations using different techniques such as UV/Vis, FTIR and X-ray photoelectron spectroscopies (XPS) together with transmission electron microscopy and size/zeta potential measurements...
December 21, 2017: Colloids and Surfaces. B, Biointerfaces
Seyedeh Masumeh Ghaseminezhad, Seyed Abbas Shojaosadati, Rikke Louise Meyer
Bacterial biofilms are a common cause of the persistence of chronic wounds, and continue to be an unsolved problem in infection microbiology due to their tolerance to antibiotics. Silver nanoparticles (Ag-NPs) have attracted attention as an alternative to antibiotics for treatment of wound infections, but their use is challenged by limited tissue penetration and high cytotoxicity. The aim of this study was to show that combination of Ag nanoparticles with Fe3O4 to produce Ag/Fe3O4 nanocomposites (NCs) can overcome these problems, as they penetrate and eradicate biofilms when applying a magnetic field...
December 21, 2017: Colloids and Surfaces. B, Biointerfaces
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