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International Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/29228880/a-recurrence-of-bilateral-diffuse-sclerosing-lobular-hyperplasia-of-breast-a-case-report
#1
Osama Elfituri, Snehal Sonawane, Haoliang Xu, Michael A Warso, Elizabeth Wiley
Mammary sclerosing lobular hyperplasia is an uncommon benign fibroproliferative lesion of adolescent and young women, often of African American heritage with an incidence of ~3%. Patients generally complain of a palpable, painless, or slightly tender and well-defined lump in breast. Very rarely, this lesion may be bilateral and diffuse. The definitive diagnosis of sclerosing lobular hyperplasia requires histopathologic evaluation. Here, we describe a case of diffuse sclerosing lobular hyperplasia in a 29-year-old African American woman that required bilateral mastectomy and recurred bilaterally requiring second resections...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29228842/mammary-analogue-secretory-carcinoma-of-the-thyroid-mimicking-locally-advanced-papillary-thyroid-carcinoma-a-rare-case-report
#2
Haihui Liao, Ashraf Khan, Patricia M Miron, Kristine M Cornejo
Mammary analogue secretory carcinoma (MASC) harboring ETV6 gene rearrangements was first described in the salivary gland with a relatively favorable prognosis and a possible molecular therapeutic target with pan-Trk inhibitors. Recently, primary MASC of the thyroid gland has been reported. We report a case of a 4.0 cm MASC arising from the left thyroid of a 58-year-old female with extrathyroidal extension. Initially, it was diagnosed by fine needle aspiration as suspicious for papillary thyroid carcinoma (PTC) and subsequently called a poorly differentiated carcinoma on resection...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29212404/low-grade-fibromyxoid-sarcoma-with-striking-zonation
#3
Dinesh Rakheja, James R Seaward, Charles F Timmons
No abstract text is available yet for this article.
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29212393/-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-with-focal-spindle-cell-metaplasia
#4
Grégoire Arnoux, Marc Pusztaszeri
"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) is a recent reclassification of the encapsulated follicular variant of papillary thyroid carcinoma, which is supposed to reflect its indolent clinical behavior and to prevent overtreatment of patients with this neoplasm. The diagnosis of NIFTP can only be made histologically on the surgical specimen according to specific inclusion and exclusion criteria, which requires the examination of the whole nodule and its capsule. Spindle cell proliferations, especially of follicular cell origin, arising within thyroid follicular neoplasms are very rare and may cause diagnostic difficulties...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29207904/graft-versus-host-disease-with-early-cytomegalovirus-infection-in-gastrointestinal-tract-biopsies
#5
Belinda L Sun, Richa Jain, Charmi Patel, Achyut K Bhattacharyya
Gastrointestinal (GI) graft-versus-host disease (GVHD) and cytomegalovirus (CMV) infection often simulate each other. However, distinction between GVHD and CMV infection is critical in the management of immunosuppression for transplant recipients. This study retrospectively reviewed 16 patients diagnosed with GVHD from 2010 to 2016 and found 4 cases (25%) coinfected with CMV. Two cases were initially diagnosed as GVHD only but found to have CMV infection by serological testing within 3 days after immunosuppression treatment for GVHD...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29207889/primary-carcinosarcoma-of-the-vagina-associated-with-differentiated-squamous-intraepithelial-neoplasia-in-a-patient-with-complete-uterine-prolapse-case-report-and-review-of-the-literature
#6
Emina Babarović, Karla Sladoljev, Ena Perin, Marko Klarić, Ružica Karnjuš-Begonja, Tamara Sinožić, Morana Dinter, Lana Glavan Gačanin, Senija Eminović
Vaginal carcinosarcomas (VCSs) are rare and clinically aggressive neoplasms. Primary vaginal malignancies are among the rarest malignant tumors, so clear management guidelines and optimal therapy, especially in the presence of significant pelvic organ prolapse, has not been determined. Here, we present a case of primary VCS closely associated with differentiated squamous intraepithelial neoplasia (DSIN), from which it appeared to have arisen in a postmenopausal patient with complete uterine prolapse. The unusual presentation of our case with DSIN in the adjacent vaginal epithelium with possible diagnostic pitfalls emphasizes the need for systemic presentation of these cases to help pathologists and clinicians know that such lesions can initially present in a patient with complete uterine prolapse...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29198143/ebv-hhv-8-multicentric-castleman-disease-with-plasmablastic-aggregates-in-an-hiv-man-an-evolving-clinicopathologic-entity
#7
Aditya Shivane, Amy Pearce, Nadia Khatib, Mark E F Smith
We report a case of EBV+ and HHV-8+ multicentric Castleman disease with plasmablastic aggregates in an HIV-positive individual. A 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be HIV positive. Investigations showed cervical lymphadenopathy and splenomegaly. He was treated for HIV and his symptoms resolved. His symptoms recurred in January 2016, and a provisional diagnosis of multicentric Castleman disease was entertained...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29198159/cystic-hypersecretory-hyperplasia-of-breast
#8
Kamaljeet Singh, Stephen Falkenberry, Brendan Eklund, M Ruhul Quddus
No abstract text is available yet for this article.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29198158/ureteritis-cystica-presenting-as-a-single-polypoid-mass
#9
Raffaella Santi, Alberto Martini, Donata Villari, Gabriella Nesi
No abstract text is available yet for this article.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29198156/mixed-ovarian-tumor-composed-of-brenner-tumor-and-adult-type-granulosa-cell-tumor-a-case-report-of-a-very-rare-mixed-ovarian-tumor-and-a-review-of-the-literature
#10
Judit Tamás, Ildikó Vereczkey, Erika Tóth, Erzsébet Csernák, Katalin Purcsi, Imre Pete
A combination of ovarian tumors with the same histogenetic origin but different histologic subtype is relatively common, whereas a co-occurrence of tumors with different histogenetic origin is rare. We report a case of mixed ovarian tumor composed of Brenner tumor and adult-type granulosa cell tumor, a combination that to the best of our knowledge has not been reported in the literature until now.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29198145/pleomorphic-lobular-carcinoma-a-controversially-aggressive-variant-of-invasive-lobular-carcinoma-of-the-breast
#11
Amrou Abdelkader, Julie M Jorns
No abstract text is available yet for this article.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29198144/the-great-imitator-syphilis-presenting-as-an-inflammatory-pseudotumor-of-liver
#12
Tom C DeRoche, Aaron R Huber
No abstract text is available yet for this article.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29183227/malignant-mixed-germ-cell-tumor-overgrowing-a-gonadoblastoma-in-a-female-with-a-46-xx-karyotype-a-case-report
#13
Maria A Arafah, Leen E Raddaoui
Gonadoblastoma is an uncommon ovarian tumor arising primarily in females with gonadal dysgenesis and a 46, XY karyotype. Germ cell tumors arising within and/or overgrowing a gonadoblastoma have been reported. We report a rare case of a malignant mixed germ cell tumor (yolk sac tumor and choriocarcinoma) arising in a gonadoblastoma of the left ovary in a 19-year-old female with a 46, XX karyotype. The patient's initial α-fetoprotein level was 20 000 KIU/L. The patient underwent a laparoscopic unilateral salpingo-oophorectomy with omentectomy and peritoneal washing followed by adjuvant chemotherapy...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29183204/diffuse-alveolar-septal-amyloidosis-associated-with-multiple-myeloma
#14
Magda Zanelli, Maria Cecilia Mengoli, Francesco Puma, Lucia Spaggiari, Filippo Lococo, Loredana De Marco, Stefano Ascani
No abstract text is available yet for this article.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29172920/clinicopathologic-features-of-benign-neurogenic-tumor-of-urinary-bladder
#15
Cheol Lee, Bohyun Kim, Boram Song, Jeong Hwan Park, Kyung Chul Moon
BACKGROUND: Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis is very important because the clinical course of each disease, even within the same diseases, is quite variable. In this study, we investigated 7 benign neurogenic tumors to better understand the rare disease entity in the urinary bladder by analyzing histological and immunohistochemical findings and comparing clinicopathologic features...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29172820/a-sclerosing-perineurioma-with-collagen-rosette-formation-benign-mimic-of-low-grade-fibromyxoid-sarcoma
#16
David Creytens, Liesbeth Ferdinande, Jo Van Dorpe
We report the case of a sclerosing perineurioma with conspicious collagen rosette formation in a 20-year-old male presenting with a firm, painless nodule on the palmar side of his right ring finger. The main differential diagnosis is a low-grade fibromyxoid sarcoma. The distinction between these entities is important because low-grade fibromyxoid sarcoma has a metastatic potential, while, as a rule, perineuriomas are benign. The presence of collagen rosettes in this current case makes this distinction even more difficult given that approximately 30% of low-grade fibromyxoid sarcoma cases show the focal presence of collagen rosettes...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29172819/arias-stella-reaction-with-signet-ring-like-cell-histomorphology
#17
Andrea Hernandez, Jeanine Chiaffarano, Khushbakhat Mittal, Alan Marcus
Cells with their nucleus pushed to the periphery in a crescent-like fashion by intracytoplasmic vacuole(s) are referred to as signet ring cells when the vacuole(s) contain mucin and signet ring-like cells when they are empty or contain a material other than mucin. Signet ring cells are commonly associated with adenocarcinomas. These cells are uncommon in the endometrium and have been found to be associated with both malignant and benign processes. We report the first case of signet ring-like cells within endometrial glands with Arias-Stella reaction...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29169286/sclerosing-mucoepidermoid-carcinoma-in-the-parotid-gland-with-crtc1-maml2-fusion-a-case-report
#18
Kei Yabuki, Atsuji Matsuyama, Eisuke Shiba, Gunji Nagatani, Masanori Hisaoka
In this article, we report a case of sclerosing mucoepidermoid carcinoma (MEC) arising in the parotid gland, with CRTC1-MAML2 gene fusion. A 73-year-old woman with a mass in the right parotid region was referred to our hospital. Radiological imaging tests revealed a well-defined mass, measuring 25 mm in diameter, with foci of calcification in the deep lobe of the parotid gland, extending to the parapharyngeal space. Microscopically, the tumor was composed of a proliferation of atypical glandular epithelial cells having intracytoplasmic mucin, squamoid cells, and intermediate cells arranged in nests embedded in a fibrosclerotic stroma, associated with a dense chronic inflammatory infiltrate containing immunoglobulin G4-immunoreactive plasma cells...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29169281/pitfalls-of-frozen-section-diagnosis-for-paraganglioma-a-clinicopathologic-analysis-and-review-of-the-literature
#19
Bomi Kim, Youngeun Yoo, Junghye Lee, Sanghui Park, Min-Sun Cho, Sun Hee Sung, Ghee Young Kwon
Few paraganglioma (PG) cases include frozen section diagnoses, and therefore, the accuracy of frozen section diagnosis for PG remains unknown. To better understand the histologic characteristics and pitfalls of frozen section findings for PG, 15 PG cases with frozen section diagnoses were selected from 12 articles through PubMed (1984-2015). In addition, we included 3 cases of PG for which intraoperative consultations were requested during a 5-year period (2012-2016) in 2 hospitals. Seven PGs were from the thyroid; 2 from the pancreas; 4 from the mediastinum, retroperitoneum, or mesentery; 1 from the middle ear; and 4 from the urinary bladder (UB)...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29169276/iatrogenic-kaposi-s-sarcoma-in-an-hiv-negative-young-male-with-crohn-s-disease-and-iga-nephropathy-a-case-report-and-brief-review-of-the-literature
#20
Annika L Windon, Stuti G Shroff
BACKGROUND: Kaposi's sarcoma (KS) is a vascular tumor arising in association with human herpesvirus-8 (HHV-8) infection, and different variants show different clinical presentations. Isolated intestinal KS in the background of Crohn's disease (CD) is exceedingly rare with only 3 cases reported in the English literature (from 1966 to 2016). CASE PRESENTATION: Herein, we report a case of intestinal KS in a 21-year-old HIV-negative Ethiopian male with a long-standing history of steroid therapy for his underlying IgA nephropathy...
November 1, 2017: International Journal of Surgical Pathology
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