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International Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/28201927/histologic-findings-and-cytological-alterations-in-thyroid-nodules-after-radioactive-iodine-treatment-for-graves-disease
#1
Siba El Hussein, Yumna Omarzai
Unlike the well-documented relation between radiation to the neck and development of papillary thyroid carcinoma, a causal association between radioactive iodine treatment for Graves' disease and development of thyroid malignancy is less defined. However, patients with a background of thyroid dysfunction presenting with clinically palpable thyroid nodules are followed more closely than the average population, and fine needle aspiration is recommended in such circumstances. Cytological examination of aspirates, and histologic examination of tissue provided from patients with a known history of Graves' disease, managed by radioactive iodine therapy can create a diagnostic dilemma, as the distinction between radiation effect and a malignant primary thyroid neoplasm can be very challenging...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28193096/dedifferentiated-liposarcoma-of-the-retroperitoneum-with-heterologous-osteosarcomatous-differentiation-and-a-striking-aneurysmal-bone-cyst-like-morphology
#2
Carole Van Haverbeke, Jo Van Dorpe, Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande, David Creytens
A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28193095/intraocular-ependymoma-with-blood-filled-spaces
#3
Aditi Dewan, Ravindra Kumar Saran, Smriti Nagpal Gupta, Deepanjali Arya, Ruchi Goel
Intraocular glial lesions are rare and include retinal gliosis, hamartomas, and astrocytomas and rarely ependymomas. Ependymomas are slow-growing glial tumors preferentially arising in the central nervous system (CNS), occasionally presenting at sites outside the CNS, with only 2 cases of primary retinal ependymoma reported till date. We report herein the third such case of a 20-year-old male who presented with a painful blind eye. The enucleated specimen showed presence of a glial tumor with cells arranged in sheets as well as few true rosettes and pseudo-rosettes and an immunohistochemical profile similar to a classical ependymoma at usual sites in the CNS...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28178894/adenocarcinoma-of-the-lung-metastatic-to-the-ovary-with-a-signet-ring-cell-component
#4
Giovanna Giordano, Nelly Cruz Viruel, Enrico Maria Silini, Francisco F Nogales
A nonsmoker 45-year-old woman, presented with a solid right ovarian mass. Microscopic examination revealed heterogeneous histology with tubular formations and extensive signet ring cell component that resembled the usual appearance of metastatic gastric carcinoma to the ovary. Moreover, the histology also showed solid nests of cells with a microvacuolated basophilic cytoplasm similar to those found in adenosquamous cervical carcinoma of glassy cell type. However, analysis of the patient's past history revealed a lung adenocarcinoma, diagnosed 4 years before, which prompted an immunohistochemical differential diagnosis, showing a strong expression for TTF-1 and Napsin A...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28145149/axillary-skip-metastases-and-the-false-negative-rate-of-sentinel-lymph-node-biopsy-in-patients-with-breast-cancer-are-related-to-negative-aldh-1-expression-and-ki-67-expression
#5
Woo Gyeong Kim, JungSun Lee
Breast cancer stem cells (CSCs) have been hypothesized to be the driving force behind tumorigenesis and metastasis. In this study, we evaluated the relationships between CSC expressions in primary breast cancers and corresponding metastatic sentinel and nonsentinel lymph nodes (SLNs and NSLNs). The clinical implications of these relationships were also investigated. CSC expressions were evaluated in 167 breast cancer specimens and associated lymph node biopsies (when present). We used double immunohistochemistry of CD44/CD24 and single immunohistochemistry of ALDH-1 on paraffin-embedded breast tissue, SLN, and NSLN specimens...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112042/peritoneal-deciduoid-mesothelioma
#6
Nicole Dominiak, Whitney Graybill, William Gunning, Mary S Richardson, Laura S Spruill
This report highlights a diagnostically challenging case of diffuse deciduoid mesothelioma occurring in the peritoneum of a 25-year-old woman, 8 months postpartum. Optimally debulked tumor consisted of sheets of polygonal cells arranged in solid, trabecular, and pseudopapillary configurations, with vesicular, occasionally grooved nuclei and small nucleoli. A barrage of immunohistochemical stains revealed an unusual staining pattern characterized by diffusely positive keratin, WT-1, and mesothelin staining, but lack of calretinin positivity...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112041/braf-k601e-mutation-in-a-follicular-thyroid-adenoma
#7
Elisabetta Macerola, Liborio Torregrossa, Clara Ugolini, Sohail Bakkar, Paolo Vitti, Guido Fadda, Fulvio Basolo
BRAF mutations represent the most common genetic alteration in papillary thyroid carcinoma (PTC). The p.V600E mutation is specific for the classic and tall-cell variants of PTC and has been associated with a more aggressive biologic behavior. On the other hand, the p.K601E mutation is peculiar to the follicular variant of PTC, and seems to be a favorable prognostic indicator. A 12-year-old boy presented with a 10-mm left-sided thyroid nodule. Fine-needle aspiration cytology reported the lesion as suspicious for a follicular neoplasm (Bethesda category IV)...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112040/intralymphatic-histiocytosis-of-the-appendix-and-fallopian-tube-associated-with-primary-peritoneal-high-grade-poorly-differentiated-adenocarcinoma-of-m%C3%A3-llerian-origin
#8
Tien Anh N Tran, Quang Tran, J Andrew Carlson
Intralymphatic histiocytosis (ILH) is a peculiar pathological process characterized by the collections of benign histiocytes in dilated lymph vessels. Although the majority of ILH patients present clinically with various forms of cutaneous manifestation, rare extracutaneous incidences have been reported in the literature. To date, ILH has not been described in an internal visceral organ. We report the case of a 68-year-old woman who underwent an appendectomy during a surgical procedure for a primary peritoneal high-grade, poorly differentiated adenocarcinoma of Müllerian origin...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112039/scrotal-histoplasmosis-masquerading-as-fournier-s-gangrene
#9
Ritesh Sachdev, Ruchika Kumar Goel, Saurabh Malviya, Shalini Goel, Smeeta Gajendra
No abstract text is available yet for this article.
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112002/tumiform-colonic-endometriosis-masquerading-as-large-bowel-malignancy
#10
Smeeta Gajendra, Ishani Mohapatra, Bhawna Jha, Manavi Dang, Ritesh Sachdev
No abstract text is available yet for this article.
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27628157/hepatocellular-carcinoma-with-dubin-johnson-like-pigment-in-a-patient-with-chronic-hepatitis-b
#11
Juan Putra, Sara C Lewis, Swan N Thung
No abstract text is available yet for this article.
April 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27481892/atypical-ductal-hyperplasia-bordering-on-ductal-carcinoma-in-situ
#12
Gary Tozbikian, Edi Brogi, Christina E Vallejo, Dilip Giri, Melissa Murray, Jeffrey Catalano, Cristina Olcese, Kimberly J Van Zee, Hannah Yong Wen
BACKGROUND: The clinical implications of the diagnosis of atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) are very different. Yet there are "borderline" breast lesions that have characteristics of both ADH and DCIS. We examined interobserver diagnostic variability for such lesions and correlated pathologic features of the lesions with clinical outcomes. METHODS: We identified all cases of borderline ADH/DCIS lesions treated at our center from 1997 to 2010...
April 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27831531/subareolar-sclerosing-ductal-hyperplasia
#13
Esther Cheng, Timothy M D'Alfonso, Maria Arafah, Rebecca Marrero Rolon, Paula S Ginter, Syed A Hoda
Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary lesion (left 22, right 13) with a mean size of 1.3 cm (range = 0.4-3.0 cm), and showed florid and papillary epithelial hyperplasia with dense sclerosis without involvement of nipple or areolar epidermis...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27777331/pseudolipomatosis-in-endometrial-specimens-does-not-represent-uterine-perforation
#14
Alexis Heller
BACKGROUND: Specimens of endometrial biopsies can sometimes present with an artifact within blood, composed of optically clear vacuoles mimicking adipose tissue, pseudolipomatosis. This artifact can be mistaken for adipose tissue and lead to an overdiagnosis of uterine perforation. CASE: We describe the case of pseudolipomatosis seen within the evacuated products of conception from a missed abortion. RESULTS: Areas of vacuolization in the blood clot mimicked adipose tissue...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27605090/the-rare-phenomenon-of-tumor-to-tumor-metastasis
#15
Brett Matthew Lowenthal, Oluwole Fadare
No abstract text is available yet for this article.
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27571793/lakes-of-extramedullary-hematopoiesis-in-a-renal-hemangioma-with-extensive-nephrocalcinosis
#16
Smita Patel, Ritu Ghai
No abstract text is available yet for this article.
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27571792/russell-body-inflammatory-polyp
#17
Ryan F Coates, Nicholas Ferrentino, Michelle X Yang
Russell body gastroenteritis has been reported as a reactive inflammatory process in most cases and many of the reports were from the upper gastrointestinal tract, especially the stomach, which may be associated with Helicobacter pylori infection and rarely associated with gastric carcinoma. Russell body containing Mott cells have been rarely seen in Barrett's esophagus and duodenum, and only 2 cases have been reported in colon, including a transplant patient with diarrhea and a rectal tubulovillous adenoma...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27571791/pseudosarcomatous-vaginal-polyp
#18
Alexis Heller, Adanna Ukazu, Qing Wang
BACKGROUND: Although rare, pregnant women can present with fibroepithelial polyps of the vagina. Most likely hormonally related, these polyps have been described in various locations of the lower female genital tract. They can be mistaken for malignant lesions due to hypercellularity and cytologic atypia. CASE: We describe the case of a 31-year-old woman who presented with a polyp of the vagina during a postpartum visit. RESULTS: Atypical cells were seen in hypercellular areas of the stroma of the polyp...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27543510/circulating-breast-carcinoma-cells-mimicking-therapy-related-acute-myeloid-leukemia
#19
Daniel J Rowan, Valentina Logunova, Peter van Tuinen, Horatiu Olteanu, Jess F Peterson
Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry and fluorescence in situ hybridization (FISH). Bone marrow histology in conjunction with immunohistochemical stains was also evaluated. A population of atypical cells with blast-like morphology was present in the peripheral blood...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27543509/differential-expression-of-%C3%AE-catenin-egfr-ck7-ck20-muc1-muc2-and-cdx2-in-intestinal-and-pancreatobiliary-type-ampullary-carcinomas
#20
Iraklis Perysinakis, Emilia Minaidou, Vasileia Leontara, Dimitrios Mantas, Georgios C Sotiropoulos, Hercules Tsipras, George N Zografos, Ilias Margaris, Gregory Kouraklis
INTRODUCTION: The purpose of this study was to associate immunohistochemical expression of β-catenin, EGFR, CK7, CK20, MUC1, MUC2, and CDX2 in ampullary adenocarcinomas with the type of differentiation and prognosis. METHODS: Forty-seven patients with ampullary adenocarcinoma who underwent pancreatoduodenectomy with curative intent from 1997 to 2014 were included in this study. Nine patients with perioperative death were included in the association analysis but excluded from survival analysis...
February 2017: International Journal of Surgical Pathology
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