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International Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/28201927/histologic-findings-and-cytological-alterations-in-thyroid-nodules-after-radioactive-iodine-treatment-for-graves-disease
#1
Siba El Hussein, Yumna Omarzai
Unlike the well-documented relation between radiation to the neck and development of papillary thyroid carcinoma, a causal association between radioactive iodine treatment for Graves' disease and development of thyroid malignancy is less defined. However, patients with a background of thyroid dysfunction presenting with clinically palpable thyroid nodules are followed more closely than the average population, and fine needle aspiration is recommended in such circumstances. Cytological examination of aspirates, and histologic examination of tissue provided from patients with a known history of Graves' disease, managed by radioactive iodine therapy can create a diagnostic dilemma, as the distinction between radiation effect and a malignant primary thyroid neoplasm can be very challenging...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28193096/dedifferentiated-liposarcoma-of-the-retroperitoneum-with-heterologous-osteosarcomatous-differentiation-and-a-striking-aneurysmal-bone-cyst-like-morphology
#2
Carole Van Haverbeke, Jo Van Dorpe, Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande, David Creytens
A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28193095/intraocular-ependymoma-with-blood-filled-spaces
#3
Aditi Dewan, Ravindra Kumar Saran, Smriti Nagpal Gupta, Deepanjali Arya, Ruchi Goel
Intraocular glial lesions are rare and include retinal gliosis, hamartomas, and astrocytomas and rarely ependymomas. Ependymomas are slow-growing glial tumors preferentially arising in the central nervous system (CNS), occasionally presenting at sites outside the CNS, with only 2 cases of primary retinal ependymoma reported till date. We report herein the third such case of a 20-year-old male who presented with a painful blind eye. The enucleated specimen showed presence of a glial tumor with cells arranged in sheets as well as few true rosettes and pseudo-rosettes and an immunohistochemical profile similar to a classical ependymoma at usual sites in the CNS...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28178894/adenocarcinoma-of-the-lung-metastatic-to-the-ovary-with-a-signet-ring-cell-component
#4
Giovanna Giordano, Nelly Cruz Viruel, Enrico Maria Silini, Francisco F Nogales
A nonsmoker 45-year-old woman, presented with a solid right ovarian mass. Microscopic examination revealed heterogeneous histology with tubular formations and extensive signet ring cell component that resembled the usual appearance of metastatic gastric carcinoma to the ovary. Moreover, the histology also showed solid nests of cells with a microvacuolated basophilic cytoplasm similar to those found in adenosquamous cervical carcinoma of glassy cell type. However, analysis of the patient's past history revealed a lung adenocarcinoma, diagnosed 4 years before, which prompted an immunohistochemical differential diagnosis, showing a strong expression for TTF-1 and Napsin A...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28145149/axillary-skip-metastases-and-the-false-negative-rate-of-sentinel-lymph-node-biopsy-in-patients-with-breast-cancer-are-related-to-negative-aldh-1-expression-and-ki-67-expression
#5
Woo Gyeong Kim, JungSun Lee
Breast cancer stem cells (CSCs) have been hypothesized to be the driving force behind tumorigenesis and metastasis. In this study, we evaluated the relationships between CSC expressions in primary breast cancers and corresponding metastatic sentinel and nonsentinel lymph nodes (SLNs and NSLNs). The clinical implications of these relationships were also investigated. CSC expressions were evaluated in 167 breast cancer specimens and associated lymph node biopsies (when present). We used double immunohistochemistry of CD44/CD24 and single immunohistochemistry of ALDH-1 on paraffin-embedded breast tissue, SLN, and NSLN specimens...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112042/peritoneal-deciduoid-mesothelioma
#6
Nicole Dominiak, Whitney Graybill, William Gunning, Mary S Richardson, Laura S Spruill
This report highlights a diagnostically challenging case of diffuse deciduoid mesothelioma occurring in the peritoneum of a 25-year-old woman, 8 months postpartum. Optimally debulked tumor consisted of sheets of polygonal cells arranged in solid, trabecular, and pseudopapillary configurations, with vesicular, occasionally grooved nuclei and small nucleoli. A barrage of immunohistochemical stains revealed an unusual staining pattern characterized by diffusely positive keratin, WT-1, and mesothelin staining, but lack of calretinin positivity...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112041/braf-k601e-mutation-in-a-follicular-thyroid-adenoma
#7
Elisabetta Macerola, Liborio Torregrossa, Clara Ugolini, Sohail Bakkar, Paolo Vitti, Guido Fadda, Fulvio Basolo
BRAF mutations represent the most common genetic alteration in papillary thyroid carcinoma (PTC). The p.V600E mutation is specific for the classic and tall-cell variants of PTC and has been associated with a more aggressive biologic behavior. On the other hand, the p.K601E mutation is peculiar to the follicular variant of PTC, and seems to be a favorable prognostic indicator. A 12-year-old boy presented with a 10-mm left-sided thyroid nodule. Fine-needle aspiration cytology reported the lesion as suspicious for a follicular neoplasm (Bethesda category IV)...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112040/intralymphatic-histiocytosis-of-the-appendix-and-fallopian-tube-associated-with-primary-peritoneal-high-grade-poorly-differentiated-adenocarcinoma-of-m%C3%A3-llerian-origin
#8
Tien Anh N Tran, Quang Tran, J Andrew Carlson
Intralymphatic histiocytosis (ILH) is a peculiar pathological process characterized by the collections of benign histiocytes in dilated lymph vessels. Although the majority of ILH patients present clinically with various forms of cutaneous manifestation, rare extracutaneous incidences have been reported in the literature. To date, ILH has not been described in an internal visceral organ. We report the case of a 68-year-old woman who underwent an appendectomy during a surgical procedure for a primary peritoneal high-grade, poorly differentiated adenocarcinoma of Müllerian origin...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112039/scrotal-histoplasmosis-masquerading-as-fournier-s-gangrene
#9
Ritesh Sachdev, Ruchika Kumar Goel, Saurabh Malviya, Shalini Goel, Smeeta Gajendra
No abstract text is available yet for this article.
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112002/tumiform-colonic-endometriosis-masquerading-as-large-bowel-malignancy
#10
Smeeta Gajendra, Ishani Mohapatra, Bhawna Jha, Manavi Dang, Ritesh Sachdev
No abstract text is available yet for this article.
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27913782/intravascular-large-b-cell-lymphoma-resembling-myelodysplastic-syndrome-in-the-bone-marrow
#11
Marco Pizzi, Elena Sabattini
No abstract text is available yet for this article.
December 2, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27913781/synchronous-microscopic-epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-of-the-adrenal-and-lymphoplasmacytic-lymphoma-de-novo-disease-or-transformation
#12
Mufaddal T Moonim, Alia Nasir, Jonathan Hubbard, Nicholas Ketley, Paul Fields
Lymphomas arising in the adrenal are rare, and to our knowledge, 2 cases of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphomas (DLBCL) in an adrenal pseudocyst have been reported. We report an incidental EBV-positive DLBCL arising in an adrenal pseudocyst in a 58-year-old man with a 7-year history of lymphoplasmacytic lymphoma (LPL). The DLBCL was present in the fibrinous exudate, while the LPL resided in the cyst wall. The patient underwent de-roofing of the same cyst 3 years previously; review of histology revealed foci of LPL in the cyst wall, but not of DLBCL...
December 2, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27913780/multifocal-polymorphous-hemangioendothelioma-of-the-liver-case-report-and-review-of-literature
#13
Siba El Hussein, Yumna Omarzai
We report a case of polymorphous hemangioendothelioma, a rare vascular neoplasm, arising in the liver of a 51-year-old woman. Microscopically, this neoplasm is characterized by a polymorphous blend of solid, primitive vascular and angiomatous areas in variable proportions. Polymorphous hemangioendothelioma is considered to be an intermediate-grade vascular neoplasm. In most of the reported cases, its occurrence has been in lymph nodes, but a few cases have been found in extranodal sites such as the mediastinum, spinal cord, and liver...
December 2, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28058847/focal-signet-ring-cell-high-grade-prostatic-intraepithelial-neoplasia-on-needle-biopsy
#14
Guang-Qian Xiao, Pamela D Unger
Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma on needle biopsy and demonstrated the existence of this type of HGPIN variant. The differentiation between HGPIN and intraductal carcinoma of prostate is also discussed.
December 1, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28013563/pax-5-positivity-in-anaplastic-lymphoma-kinase-negative-anaplastic-large-cell-lymphoma
#15
Indu Arun, Paromita Roy, Neeraj Arora, Saurabh Jayant Bhave, Reena Nair, Mammen Chandy
Anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a subtype of T-cell lymphomas that may mimic several other malignancies morphologically. With the help of immunohistochemistry, most cases of ALCL can be diagnosed on the basis of expression of T-cell lineage associated antigens. However, aberrations in the expression of immunohistochemical markers pose diagnostic challenges. The morphological and immunophenotypic features of ALCL show considerable overlap with classical Hodgkin lymphoma (CHL), which is a B-cell lymphoma...
December 1, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27903930/metachronous-uterine-endometrioid-adenocarcinoma-and-peritoneal-mesothelioma-in-lynch-syndrome-a-case-report
#16
Yuxin Lu, Sara Milchgrub, Gaurav Khatri, Purva Gopal
Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma that developed in a Lynch syndrome patient 10 months after diagnosis of uterine endometrioid adenocarcinoma. To our knowledge, this is the first reported case of a Lynch syndrome patient with metachronous uterine endometrioid adenocarcinoma and primary peritoneal mesothelioma...
November 30, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27831531/subareolar-sclerosing-ductal-hyperplasia
#17
Esther Cheng, Timothy M D'Alfonso, Maria Arafah, Rebecca Marrero Rolon, Paula S Ginter, Syed A Hoda
Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary lesion (left 22, right 13) with a mean size of 1.3 cm (range = 0.4-3.0 cm), and showed florid and papillary epithelial hyperplasia with dense sclerosis without involvement of nipple or areolar epidermis...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27777331/pseudolipomatosis-in-endometrial-specimens-does-not-represent-uterine-perforation
#18
Alexis Heller
BACKGROUND: Specimens of endometrial biopsies can sometimes present with an artifact within blood, composed of optically clear vacuoles mimicking adipose tissue, pseudolipomatosis. This artifact can be mistaken for adipose tissue and lead to an overdiagnosis of uterine perforation. CASE: We describe the case of pseudolipomatosis seen within the evacuated products of conception from a missed abortion. RESULTS: Areas of vacuolization in the blood clot mimicked adipose tissue...
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27605090/the-rare-phenomenon-of-tumor-to-tumor-metastasis
#19
Brett Matthew Lowenthal, Oluwole Fadare
No abstract text is available yet for this article.
February 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27571793/lakes-of-extramedullary-hematopoiesis-in-a-renal-hemangioma-with-extensive-nephrocalcinosis
#20
Smita Patel, Ritu Ghai
No abstract text is available yet for this article.
February 2017: International Journal of Surgical Pathology
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