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International Journal of Surgical Pathology

Elaine Zhong, Theresa Scognamiglio, Timothy D'Alfonso, Wei Song, Hung Tran, Inji Baek, Syed A Hoda
Recent publications have brought attention to the histopathological, immunohistochemical, and molecular aspects of the rare breast tumor resembling the tall cell variant of papillary thyroid carcinoma (BrTC). Nine archived cases of this entity were retrieved, reviewed, and compared with randomly selected tall cell variants of papillary thyroid carcinoma (ThTC). Seven of the BrTC cases as well as 5 cases of solid papillary carcinoma of breast were analyzed by Oncomine next-generation sequencing. BrTC and ThTC were histologically distinguishable by the presence of solid architecture, luminal histiocytes, and reverse polarity in the former, and psammoma bodies, giant cells, and optically clear nuclei in the latter...
September 18, 2018: International Journal of Surgical Pathology
Santiago Delgado, Stephen M Smith, Saral Mehra, Manju L Prasad
Composite paragangliomas are rare with less than 20 cases documented in the abdomen, retroperitoneum, and urinary bladder. In this article, we report the first case of composite paraganglioma in the head and neck presenting as a soft tissue mass in the neck adjacent to the carotid artery in a 50-year-old woman. We discuss the clinicopathologic findings and genetic implications, and we review the literature of this rare entity.
September 16, 2018: International Journal of Surgical Pathology
Mukul Vij, Joseph Valamparampil, Naresh Shanmugum, Srinivas Mettu Reddy, Shaman Rajindrajith, Mohamed Rela
Multidrug-resistant P-glycoprotein 3 (MDR3) is a phospholipid translocator encoded by the ABCB4 gene located on chromosome 7. MDR3 mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte into bile. Severe MDR3 deficiency typically occurs during childhood with progressive cholestasis evolving to cirrhosis and liver failure, requiring liver transplantation. In this article, we report 2 pediatric cases of severe MDR3 deficiency with paucity of interlobular bile ducts...
September 16, 2018: International Journal of Surgical Pathology
Shu Kwun Lui, Alyssa Krasinskas, Rushikesh Shah, Jessica M Tracht
Sickle cell disease has a wide range of hepatic manifestations, with acute intrahepatic cholestasis being one of the rarest and most fatal, often resulting in acute fulminant hepatic failure. Liver transplantation is an emerging but rarely utilized treatment for hepatic failure in the setting of sickle cell disease. Few such cases have been reported in the literature, with little emphasis on histopathologic correlation. We report a case of acute intrahepatic cholestasis in a patient with sickle cell disease who underwent orthotropic liver transplantation and describe novel correlating histopathologic features...
September 10, 2018: International Journal of Surgical Pathology
Gabriel Groisman, Zhenjian Cai, Edmond Sabo, Noam Harpaz
The management of patients with ulcerative colitis after proctocolectomy with ileal pouch-anal anastomosis includes independent histological assessments of inflammation in the ileal pouch and the rectal cuff. However, the distinction between pouchitis and cuffitis can be impeded both endoscopically and histologically by the combined effects of inflammation and regeneration. We investigated the use of 2 markers, hepatocyte paraffin 1 (Hep) and SATB2 (special AT-rich sequence-binding protein 2), which are expressed immunohistochemically in the small and large bowel epithelium, respectively, as ancillary methods to deal with this problem...
September 7, 2018: International Journal of Surgical Pathology
Jonathan Wawire, Katrine Hansen, M Ruhul Quddus
No abstract text is available yet for this article.
September 5, 2018: International Journal of Surgical Pathology
Khaleel I Al-Obaidy, Muhammad T Idrees
Endometriosis in men is extremely rare with only a few cases reported in the English literature. Different theories have been proposed as to its origin. In this article, we describe the clinicopathologic features of 2 cases of endometriosis occurring in male patients. The patients' ages were 50 and 43 years, and sizes were 2 and 5.2 cm, respectively. No significant chemical or hormonal exposure was identified. Both patients presented with a testicular mass. Grossly, both lesions were cystic and contained hemorrhagic fluid...
September 4, 2018: International Journal of Surgical Pathology
Caterina Rebecchini, Mounir Trimeche, Anne Rosselet, Laurence de Leval
No abstract text is available yet for this article.
September 4, 2018: International Journal of Surgical Pathology
Jessica Corean, Larissa V Furtado, Sabah Kadri, Jeremy P Segal, Lyska L Emerson
Cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) is usually an inherited malignancy and may be a presenting indicator of familial adenomatous polyposis syndrome although it may occasionally be sporadic. Known CMVPTC mutations include adenomatous polyposis coli ( APC) and β-catenin ( CTNNB1) genes. Despite its malignant classification, CMVPTC is considered to be a well-differentiated thyroid tumor with a generally good behavior. In contrast, poorly differentiated thyroid carcinoma is an aggressive tumor...
September 3, 2018: International Journal of Surgical Pathology
Eiichiro Iwata, Zsolt Orosz, James Teh, Jeremy Reynolds, Duncan Whitwell, Yasuhito Tanaka, Nicholas A Athanasou
A tailgut cyst (retrorectal cystic hamartoma) is an uncommon lesion that develops in the presacral (retrorectal) space. Malignant change in a tailgut cyst is extremely rare and presents as a soft tissue (presacral) or bone (sacral) neoplasm. We report a case of tailgut cyst in which a neuroendocrine tumor developed in a 25-year-old female. Computed tomography and magnetic resonance imaging scans revealed a sacrococcygeal malformation with absent left S4 and S5 and a partly cystic lesion within the right presacral space...
September 3, 2018: International Journal of Surgical Pathology
Albert Alhatem, Jenna Marcus, Debra S Heller
Multicystic mesotheliomas of peritoneal origin (also termed benign multicystic mesotheliomas) are uncommon and are exceptionally rare in the omentum. Lack of familiarity of this entity could lead to overinterpretation as a malignancy or present a challenge at frozen section. We describe a case of multicystic mesothelioma arising in the omentum found incidentally at laparotomy for endometriosis. Frozen section evaluation presented a challenge. Grossly, the mass in the omentum was multicystic and mucoid, raising the concern for a mucinous neoplasm...
September 2, 2018: International Journal of Surgical Pathology
Rekha Reddy, Tina R Woods, Robert W Allan, Paras Malhotra, Hiren J Mehta, Pralay K Sarkar, Brian J Boyce, Jaya R Asirvatham
NUT (nuclear protein in testis) carcinoma (NC) is an aggressive carcinoma characterized by rearrangements of the NUT gene on chromosome 15q14. Histologically, it is a poorly differentiated carcinoma composed of monotonous, medium-sized, round cells with scant amphophilic or eosinophilic cytoplasm. Foci of abrupt keratinization are often seen. In this report, we compare the morphology of 2 cases of NC. The first case shows characteristic features of uniform, round epithelioid cells admixed with foci of abrupt keratinization...
August 27, 2018: International Journal of Surgical Pathology
Nick Baniak, Scott Adams, Cheng-Han Lee, Rajni Chibbar, Rani Kanthan
Endometrial stromal sarcoma is a rare uterine tumor associated with favorable outcomes despite its ability to recur and metastasize to distant sites. Most recurrences are local, being limited to the abdomen/pelvis, but distant metastases can occur. Metastatic endometrial stromal sarcoma can occur many months to years after the original diagnosis or may present prior to the primary, potentially creating a diagnostic challenge. We report a bi-institutional review of 10 cases of endometrial stromal sarcoma with extrapelvic metastases without a prior history of endometriosis...
August 20, 2018: International Journal of Surgical Pathology
Thomas Albrecht, Benjamin Goeppert
No abstract text is available yet for this article.
August 20, 2018: International Journal of Surgical Pathology
Caroline Bsirini, Pratyusha Tirumanisetty, Joseph N Dytoc, Diana Agostini-Vulaj, Christopher Steevens, Asad Ullah, Aaron R Huber
Although pancreatic and gastric heterotopias are common findings in the gastrointestinal tract, heterotopic respiratory mucosa (HRM) in the rectum is extremely rare and has only been reported twice previously. We are presenting, to our knowledge, the third case of HRM in the rectum. A 56-year-old man with a history of chronic diarrhea presented for diagnostic colonoscopy, where he was found to have a rectal subepithelial nodule. He was subsequently referred to a tertiary medical center for further evaluation with rectal endoscopic ultrasound...
August 16, 2018: International Journal of Surgical Pathology
Sabri Selcuk Atamanalp
No abstract text is available yet for this article.
August 1, 2018: International Journal of Surgical Pathology
Magda Zanelli, Gaia Goteri, Maria Cecilia Mengoli, Debora Capelli, Loredana De Marco, Riccardo Valli, Maurizio Zizzo, Stefano Ascani
No abstract text is available yet for this article.
August 1, 2018: International Journal of Surgical Pathology
Neda Mirzamani, Xinmin Zhang, Judith Brody, Silvia G Spitzer, Filiz Sen, Peihong Hsu
Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (CHL) are of B-cell origin. In a small number of CHL cases, the tumor cells can express T-cell antigens. CD8 expression in this setting is extremely rare. We identified 5 cases of CHL with aberrant CD8 expression from our database. The patients included 3 men and 2 women with a median age of 33 years (range = 20-59 years). All the patients initially presented with lymphadenopathy and variable number of RS cells. Two cases were classified as mixed cellularity type that showed prominent vascular proliferation mimicking peripheral T-cell lymphoma...
July 30, 2018: International Journal of Surgical Pathology
Norio Motoda, Munehiko Onda, Munenaga Nakamizo, Ryuji Ohashi, Kimihiro Okubo, Zenya Naito
Crystalloid granuloma (CG) of salivary gland is an extremely rare inflammatory disease, and only 6 cases have been reported in the English literature. CG is histologically characterized by a granulomatous reaction to amylase crystalloid deposition. A 73-year-old woman presented with a painful left neck mass. Computed tomography depicted a mass located in the lower pole of the left parotid gland, suspicious for a tumoral lesion. Preoperative fine needle aspiration cytology found amylase crystalloid deposition with a few inflammatory cells...
July 27, 2018: International Journal of Surgical Pathology
Bharat Rekhi, Ayushi Sahay, Ajay Puri
A dedifferentiated adamantinoma is a rare subtype of an adamantinoma, associated with a relatively aggressive clinical course, with less than 10 such cases reported so far. A 25-year-old-male presented with pain in his right leg of 1-year duration. Imaging disclosed a well-defined lytic, destructive lesion in his proximal tibia with a cortical break and a soft tissue component. Microscopic examination of the biopsy and resected specimen showed nests and clusters of atypical epithelial cells, along with significant areas showing markedly pleomorphic and spindly sarcomatous cells with interspersed mitotic figures and areas of stromal hyalinization...
July 25, 2018: International Journal of Surgical Pathology
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