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International Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/29781360/sea-anemone-tumor-macroscopic-diagnosis-of-cardiac-papillary-fibroelastoma
#1
Chiara Mignogna, Andrea Amorosi, Pasquale Mastroroberto
No abstract text is available yet for this article.
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29774790/clear-cell-chondrosarcoma-with-chondroblastoma-like-features-a-case-for-team-diagnosis
#2
Ryan M Kiefer, John Wojcik, Kumarasen Cooper, Kristy L Weber, Ronnie Sebro
Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an osteolytic lesion with adjacent area of sclerosis in the proximal left femur. Magnetic resonance imaging demonstrated a marrow-infiltrative lesion with periosteal reaction and thickened enhancing periosteum...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29774785/development-of-a-management-algorithm-for-the-diagnosis-of-cellular-fibroepithelial-lesions-from-core-needle-biopsies
#3
Jaehag Jung, Eunyoung Kang, Su Min Chae, Hyojin Kim, So Yeon Park, Bo La Yun, Sun Mi Kim, Mijung Jang, Sung-Won Kim, Eun-Kyu Kim
PURPOSE: Surgical excision is recommended for complete evaluation of cellular fibroepithelial lesions identified from core needle biopsy. The purpose of this study was to determine factors associated with phyllodes tumor among cellular fibroepithelial lesions from core biopsies and develop a scoring system to predict the risk of phyllodes tumor. METHODS: We retrospectively reviewed clinical data of 169 breast lesions that were diagnosed as cellular fibroepithelial lesions from core needle biopsy at the Seoul National University Bundang Hospital between March 2005 and January 2013...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29772933/the-approach-to-solitary-fibrous-tumors-are-clinicopathological-features-and-nomograms-accurate-in-the-prediction-of-prognosis
#4
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Joel Jia Yi Soon, David Yue Zhao, Nicholas Brian Shannon, Sathiyamoorthy Selvarajan, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Currently, factors such as size, mitotic rate, and degree of necrosis have been shown to influence survival in patients with solitary fibrous tumors (SFTs); however, there remains no consensus regarding the associations between tumor characteristics and the malignant nature of these tumors. The aim of this article was to identify factors that would help in prognosticating SFTs and to validate the MD Anderson Cancer Center (MDACC) SFT nomogram in the largest known series of SFTs treated in an Asian population...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29759015/morphologic-and-immunohistochemical-characteristics-of-anorectal-melanoma
#5
Ahmad Charifa, Xuchen Zhang
Anorectal melanoma is a rare aggressive disease. Due to its rarity and considerable histologic and immunohistochemical variabilities, misdiagnosis as lymphoma, carcinoma, sarcoma, and/or gastrointestinal stromal tumor is not uncommon, particularly in amelanotic cases. We reviewed histologic features and immunohistochemical stains of 19 anorectal melanoma cases. Histopathologic features were evaluated including junctional activity, melanin pigment, and morphologic features. Immunohistochemical stains were performed using Sox10, S100 protein, HMB-45, melan-A, CD56, and cytokeratins...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29745285/p16-expression-in-extramammary-paget-s-disease-of-the-vulva-and-scrotum-is-not-human-papillomavirus-related
#6
Khaleel I Al-Obaidy, Chia-Sui Kao, Muhammad T Idrees
INTRODUCTION: Extramammary Paget disease (EMPD) of the vulva has been shown to express p16 by immunohistochemistry (IHC), however, p16 expression in the vulva and scrotum has not been extensively studied in relation to human papillomavirus (HPV) within EMPD of both the vulva and scrotum. DESIGN: Twenty-two cases of EMPD (vulva, 16; scrotum, 6) were found in our laboratory information system. P16 and HPV IHC were performed. Any p16 reactivity less than 10% was considered negative...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29745281/mucinous-cystadenocarcinoma-of-the-breast-report-of-2-cases-including-one-with-long-term-local-recurrence
#7
Anupma Nayak, Ira J Bleiweiss, Kimberly Dumoff, Tawfiqul A Bhuiya
Primary mucinous cystadenocarcinoma (MCA) of breast is an exceedingly rare tumor with histologic resemblance to MCA arising in ovary, pancreas, and gastrointestinal tract. In this article, we present 2 additional cases of MCA of breast, one highlighting the diagnostic challenges of a rare entity that may potentially lead to unnecessary chemotherapy and the second case presenting with recurrence after 8 years of primary surgical excision defying the indolent behavior reported in the literature. To our knowledge, this is the first reported instance of such behavior...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29742955/heterotopic-gastric-mucosa-in-the-common-bile-duct-with-cholangiocarcinoma
#8
Yeseul Kim, Min Jung Jung, Su-Jin Shin
Gastric heterotopia within the biliary system is extremely rare. Moreover, the combination of gastric heterotopia in the bile duct with cholangiocarcinoma has not been reported. We describe a case of heterotopic gastric mucosa in the common bile duct with cholangiocarcinoma. An 80-year-old male was admitted with abdominal pain. Abdominal computed tomography revealed wall thickening from the hilar duct to the distal common bile duct. Biopsy from the distal bile duct showed only benign gastric foveolar-type epithelium and fundic glands...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29742944/subcentimetric-incidental-intrahepatic-cholangiocarcinoma-in-an-explant-liver-diagnostic-difficulty-of-a-rare-entity
#9
Suvradeep Mitra, Gude Geethanjali, Sahaj Rathi, Arunanshu Behera, Ashim Das
Incidental intrahepatic cholangiocarcinoma (iCCA) is a rare neoplastic lesion in the explant liver specimens with an approximate incidence of 0.7%. The detection of iCCA is associated with poor prognosis in the posttransplant setting. The occurrence of a subcentimetric iCCA is very rare and poses a major diagnostic challenge to the pathologist. This article presents a rare case of subcentimetric iCCA in a young male in the background of advanced stage chronic liver disease resulting from autoimmune hepatitis possibly with chronic cholangiopathy along with the histomorphological differentials...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29737225/esophageal-pyogenic-granuloma-a-case-report-and-review-of-the-literature
#10
David A Suarez-Zamora, Paula A Rodriguez-Urrego, Jaime Solano-Mariño, Fernando Sierra-Arango, Mauricio A Palau-Lazaro
Pyogenic granuloma (PG) is a capillary hemangioma mainly found in the skin and oral mucosa, but rarely described in the esophagus. We report the case of a 66-year-old man who consulted for retrosternal pain. Endoscopic studies showed a 28-mm polypoid mass located at the distal esophageal mucosa. The patient underwent endoscopic resection, and the histopathological examination showed a neoplastic proliferation of small blood vessels growing in a lobular architecture, with edematous stroma and prominent inflammatory infiltrate...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29720012/extranodal-rosai-dorfman-disease-with-mucosal-involvement-of-the-stomach-in-a-background-of-autoimmune-atrophic-gastritis
#11
Amanda Meindl, M Sambasiva Rao, Guang-Yu Yang
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, has been described involving both lymph nodes and extranodal sites, but extranodal RDD rarely involves the gastrointestinal tract. Although the etiology is unclear, several risk factors have been shown to be highly associated with this disease process, including viral infection and immune alterations. In this article, we present a case of a 79-year-old male with a history of autoimmune atrophic gastritis and multiple carcinoid tumors of the stomach presenting with a new stomach mass...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29720005/pulmonary-mycobacterial-spindle-cell-pseudotumor-a-report-of-3-cases-including-a-practical-approach-to-histopathologic-recognition-of-this-unusual-entity
#12
Katherine E Boylan, Brandon T Larsen, Brittany A Young, Erinn Downs-Kelly, Tanmay S Panchabhai, Earle S Collum, Leif Jensen, Lyska L Emerson
Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. The histopathological diagnosis of MSP in the lung lends itself to many challenges due to its rare incidence and its spindled tumor-like appearance...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29720004/pulmonary-adenocarcinoma-mimicking-desquamative-interstitial-pneumonia-report-of-2-cases-with-genetic-analysis
#13
Masashi Miyaoka, Kazuhito Hatanaka, Masayuki Iwazaki, Naoya Nakamura
We report 2 cases of pulmonary adenocarcinoma mimicking desquamative interstitial pneumonia (DIP) with genetic analysis occurring in a 74-year-old woman and a 76-year-old woman. In both cases, the tumor was mainly composed of discohesive tumor cells, which filled and floated in the alveolar space in a DIP-like pattern. The tumor cells had abnormally large round to oval nuclei with fine chromatin and relatively abundant eosinophilic cytoplasm lacking pigmentation. Immunohistochemically, tumor cells in both cases were positive for CK7, TTF-1, napsin A, E-cadherin, β-catenin, and PD-L1 (one case had high expression and the other had low expression), and negative for CK5/6, CK20, p40, and ALK...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29692211/perivascular-leiomyomatosis-a-unique-case-report
#14
Scott Wolfe, James Sullivan, Leonard Kahn
There are 3 histologically benign smooth muscle neoplasms that have unusual growth patterns. These include intravascular leiomyomatosis, benign metastasizing leiomyoma, and leiomyomatosis peritonealis desseminata. We report a unique case of perivascular leiomyomatosis. The tumor showed multiple nodules of benign smooth muscle with some of the nodules closely associated with the periphery of the medial muscle layer of venous channels. All the neoplastic nodules were located on the outer surface of venous channels, thus precluding a diagnosis of intravascular leiomyomatosis...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29687733/the-curious-case-of-pseudocysts-in-breast-cancer-specimens-an-alteration-associated-with-hydrogel-based-breast-biopsy-markers
#15
Ana P Marques, Irene Gullo, Margarida S Fernandes, Pedro A Canão, Isabel Amendoeira
No abstract text is available yet for this article.
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29681220/reactive-nodular-fibrous-pseudotumor-mimicking-metastatic-gastrointestinal-stromal-tumor-to-perigastric-lymph-node-a-case-report-and-review-of-the-literature
#16
Jinesa Moodley, Jean-Claude Cutz, Miranda Schell
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 years postsurgical treatment for biopsy-proven GIST, clinically suspicious for a recurrent/metastatic GIST. The patient had also received adjuvant tyrosine kinase inhibitor therapy. Microscopic sections from the perigastric lesion showed a spindle cell nodule felt initially to represent a GIST with posttherapeutic changes...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29673288/neuroendocrine-neoplasia-in-extranodal-marginal-zone-lymphoma-of-mucosa-associated-lymphoid-tissue-malt-lymphoma-of-the-lung-a-case-report-and-immunohistochemistry-analysis-of-eight-pulmonary-malt-lymphomas
#17
Omid Savari, Hope Hastings, Rania Rayes, Joseph F Tomashefski
Carcinoid tumorlets are peribronchiolar proliferations of neuroendocrine cells often associated with lung scars. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a non-Hodgkin's lymphoma that frequently involves the gastrointestinal tract but less commonly is described in the lung. Simultaneous occurrence of neuroendocrine neoplasms and MALT lymphoma is extraordinarily rare and has predominately been reported in the gastrointestinal tract. In this article, we describe the case of a 73-year-old female with coexisting pulmonary MALT lymphoma and carcinoid tumorlets of the right middle lobe...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29665739/pax8-positive-b-cell-lymphoma-in-adrenal-gland-masquerading-as-metastatic-renal-cell-carcinoma
#18
Rugvedita Parakh, Lin Cheng, Maria Tretiakova
Extranodal lymphomas involve adrenal glands as a mass lesion in 3% to 5% of cases as identified by imaging studies. Definitive diagnosis of the neoplasm is provided by morphological and immunophenotypical evaluation on limited tissue obtained by fine needle aspiration or core biopsy. We report a diagnostically challenging case that presented as masses involving adrenal gland and lung in the setting of a concurrent primary renal cell carcinoma. PAX8, a frequently used marker for renal cell carcinoma, was immunoreactive in the neoplastic cells of the adrenal mass, and thus highly suggestive for metastatic renal cell carcinoma...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29665738/thyroid-like-intrahepatic-cholangiocarcinoma-report-of-a-case-and-review-of-the-literature
#19
Shao-Hua Chen, Zhi-Yong Zheng, Hanlin L Wang, Ying-Hao Yu, De-Hua Zeng, Li-Juan Qu, Xian-Zong Ye
Intrahepatic cholangiocarcinoma is a relatively uncommon malignant neoplasm. We recently encountered an unusual case of intrahepatic cholangiocarcinoma that histologically resembled a thyroid carcinoma. A thorough review of the English literature revealed only 2 similar cases that have been previously reported. Immunohistochemical studies are imperative to confirm the diagnosis of cholangiocarcinoma and to exclude the possibility of metastatic thyroid carcinoma and other malignancies with thyroid-like features...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29629604/the-assessment-of-her2-gene-status-by-fluorescence-in-situ-hybridization-in-invasive-breast-carcinomas-with-equivocal-her2-immunostaining-experience-from-a-single-institution
#20
Boubacar Efared, Ibrahim S Sidibé, Sana Gamrani, Ihsane El Otmani, Fatimazahra Erregad, Nawal Hammas, Sanae Bennis, Laila Chbani, Hinde El Fatemi
BACKGROUND: A subset of breast carcinomas harbors overexpression of the human epidermal growth factor receptor 2 (HER2). Fluorescence in situ hybridization (FISH) should be performed in breast carcinomas with equivocal HER2 immunostaining (immunohistochemistry [IHC] HER2 2+). The aim of our study is to investigate clinicopathologic factors associated with HER2 status in breast invasive carcinomas with IHC HER2 2+ through FISH analysis. METHODS: This is a retrospective study including the FISH analysis of 111 patients with invasive breast carcinomas with equivocal HER2 immunostaining...
April 1, 2018: International Journal of Surgical Pathology
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