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International Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/30392418/diffuse-large-b-cell-lymphoma-with-striking-intrasinusoidal-pseudoglandular-growth-pattern-as-a-diagnostic-dilemma-mimicking-metastatic-poorly-differentiated-pancreatic-adenocarcinoma-in-an-intraabdominal-lymph-node
#1
David Yau, Manju Aron, Imran N Siddiqi
We report an unusual intrasinusoidal growth pattern of an intraabdominal diffuse large B-cell lymphoma both clinically and histologically mimicking a metastatic adenocarcinoma. A 66-year-old woman presented with a high-grade distal biliary stricture with multiple enlarged abdominal lymph nodes. Frozen section at the time of pancreatoduodenectomy ("Whipple") demonstrated cohesive nests of large atypical cells within a totally effaced lymph node presenting a diagnostic challenge. Immunohistochemistry proved this to be a diffuse large B-cell lymphoma extensively involving the sinusoids...
November 4, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30376741/coincidental-lymphangioma-and-hemangioma-in-a-single-lymph-node
#2
Katrina Collins, Joseph A DiGiuseppe
No abstract text is available yet for this article.
October 31, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30370827/enterocolic-lymphocytic-phlebitis-a-mimicking-entity
#3
Ismael Mora-Guzmán, Adolfo Pedro Alonso-Casado
No abstract text is available yet for this article.
October 29, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30370813/clear-cell-variant-of-a-follicular-thyroid-tumor-with-uncertain-malignant-potential-a-case-report
#4
C Christofer Juhlin, Robert Bränström, Ivan Shabo, Anders Höög
Follicular neoplasms of the thyroid gland are most often characterized by follicular-patterned thyrocytes with a neutrally stained cytoplasm, while a minority of cases present with oncocytic differentiation (Hürthle cell tumors). Exceedingly rare variants with a clear cell phenotype have also been reported, both as clear cell follicular thyroid adenomas (ccFTAs) and clear cell follicular carcinomas (ccFTCs). We present a patient with a 30-mm lesion in the thyroid isthmus in which the preoperative cytology proposed a follicular tumor...
October 29, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30370808/itching-for-attention-demodex-infestation-of-the-nipple
#5
Syed Hoda, Esther Cheng
No abstract text is available yet for this article.
October 29, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30370805/atypical-spindle-cell-lipomatous-tumor-with-benign-heterologous-metaplastic-cartilaginous-differentiation
#6
David Creytens, Liesbeth Ferdinande, Joost van Gorp, Jo Van Dorpe, Uta Flucke
No abstract text is available yet for this article.
October 29, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30360665/synchronous-pulmonary-adenofibroma-and-solitary-fibrous-tumor-case-report-and-review-of-the-literature
#7
Nicholas J Olson, Julianna M Czum, Francine B de Abreu, Konstantinos Linos, Candice C Black
Pulmonary adenofibroma (PAF) is a rare neoplasm that may be related to solitary fibrous tumor (SFT). A subset of PAFs harbor the NAB2-STAT6 fusion that is typical of SFT, but a significant proportion do not. Their distinction is clinically important as SFTs can potentially have an aggressive clinical course, while there has been no report of a PAF behaving in a malignant fashion. We report a case of a 60-year-old male who developed a SFT and PAF in the same lung. The SFT harbored a NAB2-STAT6 fusion, while the PAF did not have any identifiable fusion...
October 26, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30326763/palisading-and-verocay-body-prominent-orbital-leiomyosarcoma-masquerading-as-a-schwannoma
#8
Soyoung Im, Uiju Cho, Hyun Joo Choi, Sang Won Lee, Changyoung Yoo
No abstract text is available yet for this article.
October 16, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30301396/expression-of-tle1-in-malignant-melanoma-with-spindle-cell-morphology-a-potential-diagnostic-pitfall
#9
Travis J Morrell, Yiqin Xiong, April Deng, Karen Dresser, Patrick O'Donnell, Kristine M Cornejo
OBJECTIVES: Transducer-like enhancer of split 1 (TLE1) immunohistochemistry is widely used as a biomarker of synovial sarcoma. Spindle cell or desmoplastic melanoma can morphologically mimic synovial sarcoma. The aim of this study was to investigate the expression of TLE1 in melanomas with a spindle cell morphology. METHODS: A search of the surgical pathology files resulted in 57 cases of melanomas diagnosed with a spindle cell or desmoplastic component. After review, 8 cases had no definitive dermal spindle cell component and 7 cases had insufficient tissue remaining and were excluded from the study...
October 10, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30301391/russell-body-dermatitis-due-to-syphilis
#10
Paulina Henry, Liliane Marot, Louis Libbrecht
No abstract text is available yet for this article.
October 10, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30301387/large-epithelial-and-stromal-lesion-of-breast-it-s-not-always-phyllodes
#11
Jonathan Wawire, Kamaljeet Singh, M Ruhul Quddus
No abstract text is available yet for this article.
October 10, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30270691/combined-sclerosing-and-spindle-cell-rhabdomyosarcoma-in-previous-craniotomy-site-a-case-report-and-a-review-of-the-literature
#12
Hongxing Gui, Elliott Lhospital, Arthur P Staddon, Suneel N Nagda, Eric L Zager, Paul J L Zhang, John S Brooks
Sclerosing rhabdomyosarcoma (RMS) is a rare subtype of RMS with unique prominent stromal hyalinization and a pseudovascular architecture. It overlaps morphologically with spindle cell RMS and poses both diagnostic and therapeutic challenges because of its rarity and aggressive clinical course. In this article, we report a case of sclerosing RMS arising from a prior craniotomy site, which demonstrated both sclerosing and spindle cell components. A literature review of RMS with sclerosing morphology identified 122 cases...
October 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30261787/how-to-handle-lymphadenectomy-specimens-to-identify-metastasis-more-accurately-in-gynecologic-pathology
#13
Gunsu Kimyon Comert, Nazmiye Dincer, Alp Usubutun
AIM: To identify the value of processing multiple sections to detect metastasis in lymph nodes (LNs) dissected during gynecologic cancer surgery, and to evaluate the sizes of metastatic LNs in each region to compare with the largest one. MATERIALS AND METHODS: This retrospective study included 362 patients who had gynecologic cancer with at least one metastatic LN. Slides of 627 metastatic LN specimens were categorized according to the processing technique into single and more than one section (MOS) groups...
September 27, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30259765/primary-thymic-signet-ring-cell-adenocarcinoma-a-currently-unrecognized-variant
#14
Richard Benedict Supan Roxas, Marie Christine Fajatin Bernardo, Araceli Pacis Jacoba, Janet Lim-Dy, Anarose Cariaga Alvarado, Jasna Metovic, Laura Annaratone, Mauro Papotti
We describe the first case of primary thymic adenocarcinoma with signet ring cell features. The patient was a 39-year-old Filipino male who presented with a huge anterior mediastinal mass extending to the left supraclavicular fossa, which underwent an incisional biopsy. Extensive clinicoradiological work-up showed no evidence of any primary tumor in other organs, and radiological imaging confirmed a primary tumor location in the thymic area. He later developed bilateral pleural and pericardial effusions and eventually died of his tumor...
September 27, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30255727/proteinaceous-lymphadenopathy-in-a-young-patient-with-history-of-classical-hodgkin-lymphoma-a-case-report-with-literature-review
#15
Oleksandr Kravtsov, Ronald Jaffe, Gabriela Gheorghe
Proteinaceous lymphadenopathy (PLD) is a poorly defined, underreported pathological entity of uncertain etiology characterized by massive deposition of amorphous, eosinophilic, and periodic acid-Schiff-positive material involving lymph nodes, which is distinct from amyloid and clonal immunoglobulin deposition. PLD can resemble collagen sclerosis and needs to be differentiated from lymphomas with sclerosis, particularly classical Hodgkin lymphoma, nodular sclerosis type, and therefore is an important pitfall in the diagnosis of lymphoma with sclerosis...
September 26, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30251576/l1cam-immunopositivity-in-anaplastic-supratentorial-ependymomas-correlation-with-clinical-and-histological-parameters
#16
Pooja Chavali, Shilpa Rao, Sravya Palavalasa, Nandeesh Bevinahalli, Yasha T C Muthane, Nishanth Sadashiva, Vani Santosh
Supratentorial ependymomas (ST EPNs) are molecularly characterized, of which the RELA fusion positive tumors are the most common and aggressive subgroup. Moreover, histologically, anaplastic ST EPN (ST-AE) often mimic other central nervous system primary high-grade tumors resulting in a diagnostic dilemma. We aimed to study a cohort of ST-AE; evaluate the expression of two RELA fusion-associated markers-L1CAM and p65 (NF-κB); and correlate their expression with clinical and histological parameters. Cases of ST-AE diagnosed in our department from January 2011 to June 2016 (n = 72) were reviewed...
September 25, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30238810/epithelioid-hemangioendothelioma-of-the-bowel-in-crohn-s-disease-the-first-reported-case
#17
Smiljana Spasic, Iva Brcic, Rochelle Freire, Monica T Garcia-Buitrago, Andrew E Rosenberg
BACKGROUND: Epithelioid hemangioendothelioma (EHE) is an uncommon malignant endothelial neoplasm that most commonly arises in soft tissue, bone, lung, and liver. Crohn's disease (CD) is an inflammatory bowel disease of unknown etiology that is frequently associated with complications including strictures, fistulas/fissures, and neoplasms. CASE DESCRIPTION: A 43-year-old woman with a 6-year history of severe CD presented with anal pain and bleeding. She had prior partial colectomy for a stricture and a diverting ileostomy for perianal fissures and stricture...
September 21, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30227763/breast-tumor-resembling-the-tall-cell-variant-of-papillary-thyroid-carcinoma-molecular-characterization-by-next-generation-sequencing-and-histopathological-comparison-with-tall-cell-papillary-carcinoma-of-thyroid
#18
Elaine Zhong, Theresa Scognamiglio, Timothy D'Alfonso, Wei Song, Hung Tran, Inji Baek, Syed A Hoda
Recent publications have brought attention to the histopathological, immunohistochemical, and molecular aspects of the rare breast tumor resembling the tall cell variant of papillary thyroid carcinoma (BrTC). Nine archived cases of this entity were retrieved, reviewed, and compared with randomly selected tall cell variants of papillary thyroid carcinoma (ThTC). Seven of the BrTC cases as well as 5 cases of solid papillary carcinoma of breast were analyzed by Oncomine next-generation sequencing. BrTC and ThTC were histologically distinguishable by the presence of solid architecture, luminal histiocytes, and reverse polarity in the former, and psammoma bodies, giant cells, and optically clear nuclei in the latter...
September 18, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30322317/black-thyroid
#19
Nathan Y Yu, Mauricio E Gamez
No abstract text is available yet for this article.
September 17, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30222023/composite-paraganglioma-pioneering-in-the-head-and-neck
#20
Santiago Delgado, Stephen M Smith, Saral Mehra, Manju L Prasad
Composite paragangliomas are rare with less than 20 cases documented in the abdomen, retroperitoneum, and urinary bladder. In this article, we report the first case of composite paraganglioma in the head and neck presenting as a soft tissue mass in the neck adjacent to the carotid artery in a 50-year-old woman. We discuss the clinicopathologic findings and genetic implications, and we review the literature of this rare entity.
September 16, 2018: International Journal of Surgical Pathology
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