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International Journal of Surgical Pathology

Rebecca R J Collins, Bradley Barth, Stephen Megison, Cory M Pfeifer, Luke M Rice, Samar Harris, Charles F Timmons, Dinesh Rakheja
Primary visceral myopathy caused by a pathogenic mutation in the gene encoding the enteric smooth muscle actin gamma 2 ( ACTG2) affects gastrointestinal and genitourinary tracts and often presents as chronic intestinal pseudoobstruction. We present a case of pediatric onset chronic intestinal pseudoobstruction associated with a novel missense ACTG2 mutation c.439G>T/p.G147C. In addition to the known disease manifestations of feeding intolerance and intestinal malrotation, our patient had a late-onset hypertrophic pyloric stenosis and a late-onset choledochal cyst, the former of which has not previously been described in patients with ACTG2-associated visceral myopathy...
July 1, 2018: International Journal of Surgical Pathology
Liurka Lopez, Karen Schoedel, Ivy John
Diffuse-type tenosynovial giant cell tumor can rarely present as an entirely extra-articular mass, which can be misdiagnosed as a sarcoma especially when giant cells are absent, dominated by large dendritic mononuclear cells, and desmin expression is extensive.
July 1, 2018: International Journal of Surgical Pathology
Carlos Ortiz-Hidalgo, Sergio Pina-Oviedo
Hematoxylin is a basic dye derived from the heartwood of Palo de Campeche ( Haematoxylum campechianum), the logwood tree native to Mexico and Central America. Haematoxylum means "bloodwood" in reference to its dark-red heartwood and campechianum refers to its site of origin, the coastal city of Campeche on the Yucatan Peninsula, Mexico. Hematoxylin is colorless but it turns into the color dye hematein after oxidation (ripening). The dyeing property of logwood was well-known to the natives of the Yucatan Peninsula before the arrival of the Spaniards who brought it to Europe shortly after the discovery of the Americas...
July 1, 2018: International Journal of Surgical Pathology
Adele Fornelli, Nicola Zanini, Dario De Biase, Stefania Lega, Raffaele Lombardi, Michele Masetti, Elio Jovine, Carlo Fabbri, Alberto Larghi
Carcinoma of the ampulla of Vater is an uncommon neoplasm and represents 0.5% of all gastrointestinal malignancies, being less common than carcinoma of the pancreas and bile ducts. The most common ampullary tumor is the adenocarcinoma with tubular growth pattern. Signet ring cell carcinoma is extremely rare. In this article, we report a case of signet ring cell carcinoma of the ampulla of Vater showing focal neuroendocrine amphicrine differentiation and intestinal phenotype, which occurred in a 49-year-old male who is still alive 7 years after surgery, without evidence of recurrence...
July 1, 2018: International Journal of Surgical Pathology
Alexandria M Hertz, Charles K Childers, Jonathan T Wingate, Jason T Perry, Charles A Kitley, Timothy C Brand, Mark I Anderson
OBJECTIVES: To discuss an unusual presentation of solitary fibrous tumor (SFT) as well as the first description of SFT originating from the renal vein. CASE REPORT: In this article, we report the case of a 56-year-old man who presented with nonspecific epigastric pain and was found on computed tomography to have a large 10-cm renal artery aneurysm with evidence of contained rupture, segmental ischemia of the kidney, and suggestion of renal vein thrombosis. This was treated by a multidisciplinary team of urologists, vascular surgeons, and interventional radiologists with both renal artery coil embolization and radical nephrectomy...
July 1, 2018: International Journal of Surgical Pathology
Nawar Y Matti, Debra S Heller
No abstract text is available yet for this article.
July 1, 2018: International Journal of Surgical Pathology
Michael A Landau, Benjamin Zhu, Frances N Akwuole, Reetesh K Pai
Patients with stage III colonic adenocarcinoma have a spectrum of risk for recurrent disease, and histopathological variables that predict recurrence can help stratify patients into prognostic groups. To identify histopathological predictors of recurrence, we investigated the effect of implementation of the eighth edition of the American Joint Committee on Cancer (AJCC8) staging system definition of tumor deposits and International Tumor Budding Consensus Conference (ITBCC) criteria for tumor budding compared with other known prognostic variables in 256 resected colonic adenocarcinomas, including 150 stage III and 106 stage II tumors...
July 1, 2018: International Journal of Surgical Pathology
Sandeep Abhijit Pattnaik, Suvradeep Mitra, Tushar Subhadarshan Mishra, Suvendu Purkait, Pankaj Kumar, Suprava Naik
Neuromuscular and vascular hamartoma (NMVH), also known as neuromesenchymal hamartoma, is a rare hamartomatous condition of the intestine. It usually presents with submucosal humps protruding in the intestinal lumen causing obstructive features. The other clinical manifestations are hematochezia or melena and protein-losing enteropathy. The etiopathogenesis of these lesions is not well known, although an association with small bowel Cröhn's disease and diaphragm disease had been postulated, the latter related to chronic nonsteroidal anti-inflammatory drug intake...
July 1, 2018: International Journal of Surgical Pathology
Anamarija M Perry, Nathanael G Bailey, Michelle Bonnett, Elaine S Jaffe, Wing C Chan
Indolent T-cell lymphoproliferative disorder (T-LPD) of the gastrointestinal (GI) tract is a new provisional entity in the 2016 revision of the World Health Organization classification. The disease has an indolent course and progression to aggressive T-cell lymphoma has rarely been reported. We describe a case of a 37-year-old male with indolent T-LPD of the GI tract who 3 years later developed aggressive T-cell lymphoma and died of progressive disease. An infiltrate of indolent T-LPD in the GI tract and aggressive lymphoma diagnosed from the liver biopsy had similar immunophenotype, but cellular infiltrate in the liver showed more atypia compared with the GI biopsies of indolent T-LPD...
July 1, 2018: International Journal of Surgical Pathology
Hiroe Itami, Hirokazu Nakamine, Maiko Takeda, Tokiko Nakai, Tomoya Myojin, Minami Matsuoka, Shoh Sasaki, Tomoko Uchiyama, Kohei Morita, Tomomi Fujii, Kinta Hatakeyama, Chiho Ohbayashi
Although it has been described that extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) are the most common type among primary salivary gland lymphomas (SGLs), some studies revealed that the frequency of follicular lymphomas (FLs) was as high as that of MALT lymphomas. However, it has been reported that many of these FLs may have developed in lymph nodes attached to the capsule of the glands or intraglandular lymph nodes. Clinical, histological, immunohistochemical, and cytogenetic features of 11 SGL cases, which were extracted from our surgical pathology file consisting of consecutive pathology cases, were reevaluated to further characterize whether they were actually primary SGLs...
July 1, 2018: International Journal of Surgical Pathology
Christopher J Schwartz, Richard Hickman, Xuchen Zhang, Antonio Galvao Neto, Esther Adler
Mixed carcinomas in the esophagus are highly uncommon neoplasms that represent a diagnostic challenge on small tissue biopsies. We present a case of a primary mixed sarcomatoid-small cell carcinoma of the esophagus that was diagnosed after repeat sampling of the lesion. The components were morphologically distinct and could be further classified by immunohistochemistry. Next-generation sequencing identified mutations in PIK3CA and CDKN2A. The small cell component morphology was also identified in brain metastasis...
June 1, 2018: International Journal of Surgical Pathology
Amy Starr, Dong Hyang Kwon, Bhaskar Kallakury
Diffuse large B-cell lymphoma (DLBCL) is characterized by medium- to large-sized neoplastic cells that express a wide range of B-cell markers including CD19, CD20, CD22, and CD79a. Also, as this is a hematopoietic malignancy, there is expression of the leukocyte common antigen CD45. Lack of CD20 expression occurs in a specific rare heterogeneous subgroup of DLBCL including primary effusion lymphoma, plasmablastic lymphoma, ALK-positive large B-cell lymphoma, and large B-cell lymphoma arising in HHV8+ multicentric Castleman disease...
June 1, 2018: International Journal of Surgical Pathology
Chen Yang, Li Sun, Jenny Z Lai, Lixin Zhou, Zhen Liu, Yanfeng Xi, Yu Tao, Elaine Dooley, Dengfeng Cao
Primary pancreatic hepatoid carcinoma (PHC) is very rare. Here, we reported 3 such cases with review of additional 31 cases in the literature. Our 3 patients were male (83, 72, and 54 years old, respectively). Serum α-fetoprotein (AFP) was elevated in 1 patient (case 3, 8338 ng/mL) and not measured in the other two. The PHC in patient 1 (pathological stage pT2N0M0) and patient 2 (pT3N0M0) showed pure hepatocellular carcinoma (HCC)-like morphology, whereas in case 3 it was a PHC with true glandular differentiation (pT4N0M0)...
June 1, 2018: International Journal of Surgical Pathology
David A Suarez-Zamora, Paula A Rodriguez-Urrego, Camilo Soto-Montoya, Oscar Rivero-Rapalino, Mauricio A Palau-Lazaro
Solitary fibrous tumor (SFT) is a spindle-shaped cell neoplasm originally described in the pleura, but subsequently found in many anatomic sites. Only few cases of primary SFTs in the bone have been previously described in the literature. We present the case of an 86-year-old man with a 1-week history of pain in his left arm. Imaging studies demonstrated a well-defined osteolytic lesion in the proximal humerus measuring 6.1 cm in diameter. Sections showed a round to spindle-shaped cell neoplasm with prominent mitotic activity (28 mitoses per 10 high-power fields) and areas of necrosis, focally surrounding staghorn-shaped vessels...
June 1, 2018: International Journal of Surgical Pathology
Alessandra Pittaro, Alessandro Del Gobbo, Elisabetta Iofrida, Nicola Fusco
No abstract text is available yet for this article.
June 1, 2018: International Journal of Surgical Pathology
Snehal Sonawane, Osama Elfituri, Yanmin Zhang, Edgardo Yordan, Nicholas Ree
Endometrioid carcinoma is known for its diverse morphology and may pose a diagnostic dilemma when it presents with a spindle cell component. We present a case of a 65-year-old woman with postmenopausal bleeding. Physical examination showed a mass protruding from the external cervical os. The patient underwent biopsy followed by hysterectomy. Pathologic examination showed an endometrioid endometrial carcinoma with spindle cell differentiation arising in an endometrial polyp, which raised a variety of differential diagnoses...
June 1, 2018: International Journal of Surgical Pathology
Mafalda Trippel, Julia Slotta-Huspenina, Karen Becker, Tilman Rau, Stefan Paepke, Franziska Maurer-Marti, Rupert Langer
INTRODUCTION: The evaluation of the trimming surfaces (TS) of tissue blocks from frozen sections may serve as a supplementary examination tool for the intraoperative determination of resection margins of breast cancer specimens. This study aimed at the investigation of the feasibility and reliability of this technique, which has been described only very rarely in literature. METHODS: Two observers assessed digital images from TS obtained from 57 resection margins...
June 1, 2018: International Journal of Surgical Pathology
Mark Benedict, Joanna Gibson, Xuchen Zhang
No abstract text is available yet for this article.
June 1, 2018: International Journal of Surgical Pathology
Vani Bharani, Bhavana Rai, Arvind Rajwanshi, Nalini Gupta, Pranab Dey, Jasvinder Kalra, Vanita Suri, Radhika Srinivasan
BACKGROUND: The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS: The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal any cancer on the subsequent hysterectomy specimen. Clinical and pathological correlation was established. RESULTS: A total of 5 cases were retrieved with biopsy-diagnosed endometrial carcinomas, 4 endometrioid and 1 serous type, which on subsequent hysterectomies did not reveal any tumor...
June 1, 2018: International Journal of Surgical Pathology
Armen Khararjian, Rifat Mannan, Kathleen Byrnes, Norman Barker, Lysandra Voltaggio
INTRODUCTION: Colon biopsies are among the most frequently examined specimens by pathologists. Many pathology practices, ours included, review upfront levels on all gastrointestinal biopsies. In our experience, when a lesion is present on specimens labeled "colon polyp," it is readily identified on the first level. To test our hypothesis, we re-reviewed 500 cases in which a lesion was identified histologically and determined if the diagnosis could be made on the first level...
June 1, 2018: International Journal of Surgical Pathology
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