journal
MENU ▼
Read by QxMD icon Read
search

Endocrine Journal

journal
https://www.readbyqxmd.com/read/29151451/fracture-risk-assessment-tool-frax-and-for-the-diagnosis-of-osteoporosis-in-japanese-middle-aged-and-elderly-women-chiba-bone-survey
#1
Rena Oka, Masahiro Ohira, Sawako Suzuki, Tomohiko Yoshida, Hisashi Koide, Tomoaki Tanaka, Ichiro Tatsuno
Osteoporosis not only increases bone fracture risk but also affects survival in postmenopausal women. Although osteoporosis is diagnosed based on low bone mineral density (BMD) determined by dual energy X-ray absorptiometry (DXA), BMD measurement is sometimes difficult because DXA is not widely available in the community. The Fracture Risk Assessment tool (FRAX) can predict 10-year major osteoporotic fracture risk and hip fracture risk with or without femoral neck BMD. The FRAX has not been investigated adequately in community-dwelling Japanese women...
November 18, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29118296/mismatch-between-fetal-sexing-and-birth-phenotype-a%C3%A2-case-of-complete-androgen-insensitivity-syndrome
#2
Keisuke Yoshii, Yasuhiro Naiki, Yumiko Terada, Maki Fukami, Reiko Horikawa
With advancing maternal age, the number of prenatal genetic tests is increasing in many countries. Prenatal genetic tests, such as amniocentesis, chorionic villus sampling and non-invasive prenatal testing, can disclose fetal chromosomal sex, although these tests were originally designed to prenatally diagnose chromosomal aneuploidies, such as trisomy 21, 18 and 13. Complete androgen insensitivity syndrome (CAIS) is an X-linked recessive disorder caused by an androgen receptor dysfunction leading to hormone resistance...
November 9, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29109363/efficacy-and-safety-of-two-doses-of-norditropin%C3%A2-somatropin-in-short-stature-due-to-noonan-syndrome-a-2-year-randomized-double-blind-multicenter-trial-in-japanese-patients
#3
Keiichi Ozono, Tsutomu Ogata, Reiko Horikawa, Yoichi Matsubara, Yoshihisa Ogawa, Keiji Nishijima, Susumu Yokoya
This randomized double-blind multicenter trial (NCT01927861) evaluated the growth-promoting effect and safety of Norditropin(®) (NN220; somatropin) in Japanese children with short stature due to Noonan syndrome. Prepubertal children aged 3-<11 years (boys) or 3-<10 years (girls) with Noonan syndrome were randomized to receive GH 0.033 mg/kg/day (n = 25, mean age 6.57 years, 11 females) or 0.066 mg/kg/day (n = 26, mean age 6.06 years, eight females) for 104 weeks. Change in height standard deviation score (HSDS) from baseline was analyzed based on an ANCOVA model...
November 7, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29109360/investigation-of-the-pronounced-erythropoietin-induced-reduction-in-hyperglycemia-in-type-1-like-diabetic-rats
#4
Shu-Chun Kuo, Yingxiao Li, Kai-Chun Cheng, Chiang-Shan Niu, Juei-Tang Cheng, Ho-Shan Niu
Erythropoietin (EPO) is known to stimulate erythropoiesis after binding with its specific receptor. In clinics, EPO is widely used in hemodialyzed patients with diabetes. However, changes in the expression of the erythropoietin receptor (EPOR) under diabetic conditions are still unclear. Therefore, we investigated EPOR expression both in vivo and in vitro. Streptozotocin-induced type 1-like diabetic rats (STZ rats) were used to evaluate the blood glucose-lowering effects of EPO. The expression and activity of the transducer and activator of transcription 3 (STAT3), the potential signaling molecule, was investigated in cultured rat skeletal myoblast (L6) cells incubated in high-glucose (HG) medium to mimic the in vivo changes...
November 3, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29093307/warthin-like-papillary-thyroid-carcinoma-with-immunoglobulin-g4-positive-plasma-cells-possibly-related-to-hashimoto-s-thyroiditis
#5
Mitsuyoshi Hirokawa, Eijun Nishihara, Nami Takada, Miyoko Higuchi, Masumi Kotakemori, Toshitetsu Hayashi, Akira Miyauchi
Hashimoto's thyroiditis with heavy lymphoplasmacytic infiltration is a common comorbidity of immunoglobulin G4 (IgG4)-related thyroiditis and Warthin-like papillary thyroid carcinoma (WL-PTC). We hypothesized that WL-PTC may have a strong association with IgG4-related thyroiditis. To validate this hypothesis, we clinically and immunohistochemically studied 17 WL-PTC cases. Fourteen patients (82.4%) had anti-thyroglobulin antibody and were confirmed to have Hashimoto's thyroiditis through microscopic analysis...
November 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29093280/satisfaction-and-efficacy-of-switching-from-daily-dipeptidyl-peptidase-4-inhibitors-to-weekly-trelagliptin-in-patients-with-type-2-diabetes-randomized-controlled-study
#6
Mayuko Oita, Hideaki Miyoshi, Kota Ono, Akinobu Nakamura, Kyu Yong Cho, Hiroshi Nomoto, Kohei Yamamoto, Kazuno Omori, Naoki Manda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi
We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4 inhibitors for more than 3 months. Patients were randomly assigned to a treatment cohort: (1) a group that continued taking daily DPP-4 inhibitors (daily group); or (2) a group that switched from daily DPP-4 inhibitors to a weekly DPP-4 inhibitor, trelagliptin (weekly group)...
October 31, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29081443/colonoscopy-examination-requires-a-longer-time-in-patients-with-acromegaly-than-in-other-individuals
#7
Masaya Iwamuro, Miho Yasuda, Kou Hasegawa, Satoshi Fujisawa, Kanako Ogura-Ochi, Yuusaku Sugihara, Keita Harada, Sakiko Hiraoka, Hiroyuki Okada, Fumio Otsuka
This study aimed to determine the prevalence of colorectal neoplasms and to investigate the rate of and time required for cecal intubation in patients with acromegaly. A database search performed at our institution identified 29 patients with acromegaly who underwent colonoscopy. Data regarding the endoscopic, biological, and pathological examinations performed were retrospectively reviewed from the clinical records. Subsequently, the rate of and time required for cecal intubation were investigated in 23 patients with acromegaly and compared with the corresponding data of the control group...
October 28, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29070763/the-synergic-effect-of-braf-v600e-mutation-and-multifocality-on-central-lymph-node-metastasis-in-unilateral-papillary-thyroid-carcinoma
#8
Hai-Jiang Qu, Xue-Yan Qu, Ze Hu, Yan Lin, Jun-Rong Wang, Chang-Fu Zheng, Zhuo Tan
The purpose of this study is to evaluate the potential synergic effect of BRAF(V600E) mutation and multifocality on central lymph nodes metastasis (CLNM) in the patients with unilateral papillary thyroid carcinoma (PTC). We enrolled 413 patients with unilateral PTCs who accepted prophylactic unilateral or bilateral central lymph node dissection (LND). Univariate and multivariate analyses were made to determine the association between related factors and CLNM. Then, all patients were divided into 4 groups based on their status of BRAF(V600E) mutation and multifocality...
October 26, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29070768/effect-of-growth-hormone-replacement-therapy-on-plasma-diacron-reactive-oxygen-metabolites-and-endothelial-function-in-japanese-patients-the-great-clinical-study
#9
Kunihiro Suzuki, Kazunori Yanagi, Masanori Shimizu, Sho Wakamatsu, Takafumi Niitani, Soichiro Hosonuma, Masaaki Sagara, Yoshimasa Aso
Patients with growth hormone deficiency (GHD) have an increased risk of atherosclerosis and vascular mortality. Evidence suggests that endothelial dysfunction is involved in all stages of atherogenesis. This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled...
October 25, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29057768/ghrelin-protects-adult-rat-hippocampal-neural-stem-cells-from-excessive-autophagy-during-oxygen-glucose-deprivation
#10
Hyunju Chung, Junghyun Choi, Seungjoon Park
Ghrelin functions as a neuroprotective agent and saves neurons from various insults include ischemic injury. However, it remains to be elucidated whether ghrelin protects neuronal cells against ischemic injury-induced excessive autophagy. Autophagy is required for the maintenance of neural stem cell homeostasis. However, regarding autophagic cell death, it is commonly assumed that excessive autophagy leads to self-elimination of mammalian cells. The purpose of this study was to investigate the potential neuroprotection effects of ghrelin from excessive autophagy in adult rat hippocampal neural stem cells (NSCs)...
October 21, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29046499/the-assessment-of-total-antioxidant-capacity-and-superoxide-dismutase-levels-and-the-possible-role-of-manganese-superoxide-dismutase-polymorphism-in-acromegaly
#11
Muzaffer Ilhan, Seda Turgut, Saime Turan, Sema Demirci Cekic, Hayriye Arzu Ergen, Gurbet Korkmaz Dursun, Brunilda Mezani, Ozcan Karaman, Ilhan Yaylim, Mustafa Resat Apak, Ertugrul Tasan
Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014...
October 17, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29033409/evaluation-of-serum-ferritin-and-thyroid-function-in-the-second-trimester-of-pregnancy
#12
Leqi He, Chunmei Shen, Yanan Zhang, Zaoping Chen, Heyuan Ding, Jun Liu, Bingbing Zha
Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function in pregnant women during the second trimester. Pregnant women with sufficient iodine intake and normal antithyroid antibodies during the second trimester were recruited from the obstetric outpatient department of the Fifth People's Hospital of Fudan University...
October 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28978813/normal-pancreatic-%C3%AE-cell-function-in-mice-with-rip-cre-mediated-inactivation-of-p62-sqstm1
#13
Akira Honda, Koji Komiya, Akemi Hara, Ayako Fukunaka, Luka Suzuki, Takeshi Miyatsuka, Takeshi Ogihara, Yoshio Fujitani, Hirotaka Watada
Recent studies have suggested that decreased pancreatic β-cell function and mass are common features of patients with type 2 diabetes mellitus. Pancreatic β-cell homeostasis is regulated by various types of signaling molecules and stress responses. Sequestosome 1/p62 (SQSTM1, hereafter referred to as p62) is a ubiquitin-binding adaptor protein involved in cell signaling, oxidative stress, and autophagy. Because p62 appears to play an important role in maintaining mitochondrial quality control, it is possible that the loss of p62 in pancreatic β cells contributes to mitochondrial dysfunction, and thus leading to impaired glucose tolerance...
October 4, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28966224/interaction-between-bone-and-glucose-metabolism-review
#14
Ippei Kanazawa
Accumulating evidence has shown that bone and glucose metabolism are closely associated with each other. Since the risk of osteoporotic fractures is increased in patients with diabetes mellitus (DM), osteoporosis is recently recognized as one of diabetic complications, called DM-induced bone fragility. Previous studies showed that collagen cross-links of advanced glycation end products (AGEs) and dysfunctions of osteoblast and osteocyte are involved in DM-induced bone fragility. Circulating levels of AGEs and homocysteine are increased in patients with DM, and they directly impair the functions of osteoblast and osteocyte, resulting in decreased bone formation and bone remodeling...
September 30, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28966223/which-cytokine-is-the-most-related-to-weight-loss-%C3%A2-induced-decrease-in-arterial-stiffness-in-overweight-and-obese-men
#15
Hiroshi Kumagai, Asako Zempo-Miyaki, Toru Yoshikawa, Miki Eto, Rina So, Takehiko Tsujimoto, Takeshi Nishiyasu, Kiyoji Tanaka, Seiji Maeda
Obesity and increased arterial stiffness are risk factors for cardiovascular disease. A well-known characteristic of obesity is the chronic low-grade inflammatory state, and it causes elevation of arterial stiffness. Weight-loss reduces arterial stiffness and inflammatory level in obese individuals. However, it is unclear which inflammatory factor is most related to weight loss-induce decreases in arterial stiffness in overweight and obese men. Thus, the aim of this study was to determine which circulating cytokine level has the most effect on decreasing arterial stiffness after lifestyle modification...
September 30, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28966225/a-case-report-of-fulminant-type-1-diabetes-mellitus-associated-with-drug-induced-hypersensitivity-syndrome-in-an-elderly-patient-with-coxsackie-b4-virus-infection-and-human-leukocyte-antigen-a24-haplotype
#16
Ayumu Takeno, Ippei Kanazawa, Miwa Morita, Kai Takedani, Hitomi Miyake, Masahiro Yamamoto, Kyoko Nogami, Sakae Kaneko, Toshitsugu Sugimoto
Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic adverse drug reaction. Previous studies showed that DIHS is associated with the onset of fulminant type 1 diabetes mellitus (FT1D). Although genetic background and abnormalities in immune response or viral infection are considered to be associated with pathogenesis of FT1D, it remains unclear whether virus infection and specific human leukocyte antigen (HLA) typing are involved in DIHS-associated FT1D. Here, we report a case of a 78-year-old female patient with FT1D after DIHS treatment...
September 29, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28954935/neuropeptide-y-promotes-adipogenic-differentiation-in-primary-cultured-human-adipose-derived-stem-cells
#17
Min Liu, Hong Liu, Fang Liang, Xiao-Qin Song, Ping-An Hu
Neuropeptide Y (NPY) is an important neurotransmitter in the control of energy metabolism. Several studies have shown that obesity is associated with increased levels of NPY in the hypothalamus. We hypothesized that the release of NPY has coordinated and integrated effects on energy metabolism in different tissues, such as adipocyte tissue, resulting in increased energy storage and decreased energy expenditure. Whether NPY has role in the molecular mechanism of human adipocyte tissue remains unclear. We established the model of human adipose derived stem cells (hADSCs) from human adipose tissue and differentiated it into adipocytes in the presence of NPY at different concentrations (10(-15)-10(-6) mmol/L)...
September 28, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28931780/association-between-severity-of-obstructive-sleep-apnea-and-glycated-hemoglobin-level-in-japanese-individuals-with-and-without-diabetes
#18
Hideaki Kurosawa, Yoshifumi Saisho, Koichi Fukunaga, Mizuha Haraguchi, Wakako Yamasawa, Isao Kurihara, Tomoko Betsuyaku, Hiroshi Itoh
Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPAP) therapy was introduced (N = 115, 44 with T2DM, age 62 ± 11 years, BMI 27.0 ± 4.4 kg/m(2) and AHI median 36.1; interquartile range 27.2-48.1). During admission, the severity of OSA was evaluated by polysomnography, and its association with glycated hemoglobin (HbA1c) level was examined...
September 20, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28931779/the-efficacy-of-medical-treatment-in-patients-with-acromegaly-in-clinical-practice
#19
Seo Young Lee, Jung Hee Kim, Ji Hyun Lee, Yong Hwy Kim, Hyang Jin Cha, Sang Wan Kim, Sun Ha Paek, Chan Soo Shin
Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. The CAB (45...
September 20, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28904247/efficacy-and-safety-of-subgroup-analysis-stratified-by-baseline-hba1c-in-a-japanese-phase-3-study-of-dulaglutide-0-75-mg-compared-with-insulin-glargine-in-patients-with-type-2-diabetes
#20
Shizuka Kaneko, Tomonori Oura, Akiko Matsui, Tomotaka Shingaki, Masakazu Takeuchi
The efficacy and safety of once-weekly dulaglutide 0.75 mg (dulaglutide) compared with once-daily insulin glargine (glargine) in Japanese patients with type 2 diabetes were evaluated according to subgroups stratified by baseline glycated hemoglobin (HbA1c) (≤8.5% or >8.5%). This exploratory analysis of a randomized, open-label, phase 3 study included 361 patients. In both HbA1c subgroups (patients with baseline HbA1c ≤8.5% or >8.5%), a statistically significantly greater reduction in HbA1c was observed in dulaglutide-treated patients compared with glargine-treated patients after 26 weeks of treatment (HbA1c ≤8...
September 14, 2017: Endocrine Journal
journal
journal
31446
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"