Read by QxMD icon Read

Harvard Review of Psychiatry

Fanny B Cegla-Schvartzman, Santiago Ovejero, Jorge López-Castroman, Enrique Baca-García
OBJECTIVE: Diagnostic stability is the degree to which a diagnosis remains unchanged during follow-up. It is an important measure of predictive validity in bipolar disorder (BD). In this study, we review the literature concerning diagnostic stability in BD, analyze the factors contributing to diagnostic stability, and describe the implications of diagnostic boundaries and diagnostic delay. METHODS: A comprehensive literature search of MEDLINE and EMBASE databases was conducted, including all studies published from 1980 to 2016, to evaluate the diagnostic stability of BD...
October 24, 2018: Harvard Review of Psychiatry
Geneviève Sauvé, Mathieu B Brodeur, Jai L Shah, Martin Lepage
BACKGROUND: Patients in every stage of the psychosis continuum can present with negative symptoms. While no treatment is currently available to address these symptoms, a more refined characterization of their course over the lifetime could help in elaborating interventions. Previous reports have separately investigated the prevalence of negative symptoms within each stage of the psychosis continuum. Our aim in this review is to compare those prevalences across stages, thereby disclosing the course of negative symptoms...
October 24, 2018: Harvard Review of Psychiatry
Aaron J Hauptman, Diler Acar, Paul Hammerness, Jason M Fogler, Diane Stafford
No abstract text is available yet for this article.
November 2018: Harvard Review of Psychiatry
Charlie Rioux, Jean R Séguin, Joel Paris
Evolutionary models of psychopathology can shed light on gene-environment interactions. Differential susceptibility to the environment means that heritable traits can have positive or negative effects, depending on environmental context. Thus, traits that increase risk for mental disorders when the environment is negative can be adaptive when the environment is positive. This model can be applied to borderline personality disorder, with predictors such as emotional dysregulation and impulsivity seen as temperamental variations leading to negative effects in an unfavorable environment but to positive effects in a favorable environment...
November 2018: Harvard Review of Psychiatry
Torsten Klengel
Understanding the complexity and regular function of the human brain is an unresolved challenge that hampers the identification of disease-contributing components and mechanisms of psychiatric disorders. It is accepted that the majority of psychiatric disorders result from a complex interaction of environmental and heritable factors, and efforts to determine, for example, genetic variants contributing to the pathophysiology of these diseases are becoming increasingly successful. We also continue to discover new molecules with unknown functions that might play a role in brain physiology...
November 2018: Harvard Review of Psychiatry
Waguih William IsHak, Raymond Y Wen, Lancer Naghdechi, Brigitte Vanle, Jonathan Dang, Michelle Knosp, Julieta Dascal, Lobsang Marcia, Yasmine Gohar, Lidia Eskander, Justin Yadegar, Sophia Hanna, Antonious Sadek, Leslie Aguilar-Hernandez, Itai Danovitch, Charles Louy
BACKGROUND: Pain comorbid with depression is frequently encountered in clinical settings and often leads to significant impaired functioning. Given the complexity of comorbidities, it is important to address both pain and depressive symptoms when evaluating treatment options. AIM: To review studies addressing pain comorbid with depression, and to report the impact of current treatments. METHOD: A systematic search of the literature databases was conducted according to predefined criteria...
November 2018: Harvard Review of Psychiatry
Farah Ahmad, Catherine Maule, Jamie Wang, Wai Lun Alan Fung
Despite the increasing presence of Chinese communities in the West, their experiences of depression and the variations in symptoms or presentation are not well understood. Using Arksey and O'Malley's methodical framework, we conducted a scoping review of the published literature, using electronic databases MEDLINE and PsycINFO, and searched for articles published since 1999. Out of 1177 articles identified, 21 met the inclusion criteria. Thematic synthesis revealed valuable scholarly work on (1) depression rates, migration, and contextual determinants, (2) causation beliefs and help seeking, (3) acculturation and symptoms, (4) presenting symptoms and somatization, and (5) culturally sensitive assessment and care...
November 2018: Harvard Review of Psychiatry
Shelly F Greenfield
No abstract text is available yet for this article.
November 2018: Harvard Review of Psychiatry
Dawn F Ionescu, Julia M Felicione, Aishwarya Gosai, Cristina Cusin, Philip Shin, Benjamin G Shapero, Thilo Deckersbach
Major depressive disorder (MDD) is one of the most prevalent conditions in psychiatry. Patients who do not respond to traditional monoaminergic antidepressant treatments have an especially difficult-to-treat type of MDD termed treatment-resistant depression. Subanesthetic doses of ketamine-a glutamatergic modulator-have shown great promise for rapidly treating patients with the most severe forms of depression. As such, ketamine represents a promising probe for understanding the pathophysiology of depression and treatment response...
November 2018: Harvard Review of Psychiatry
Ioline D Henter, Rafael Teixeira de Sousa, Carlos A Zarate
After participating in this activity, learners should be better able to evaluate the evidence supporting the antidepressant effects of glutamatergic modulators.Both preclinical and clinical studies have implicated glutamatergic system dysfunction in the pathophysiology of mood disorders such as bipolar depression and major depressive disorder. In particular, rapid reductions in depressive symptoms have been noted in response to subanesthetic doses of the glutamatergic modulator ketamine in subjects with major depressive disorder or bipolar depression...
November 2018: Harvard Review of Psychiatry
Brian Theyel
No abstract text is available yet for this article.
September 2018: Harvard Review of Psychiatry
Abigail M Judge
In recent years, heightened attention has been paid to commercial sexual exploitation, including domestic human sex trafficking (HST), with mental health concerns named the most dominant health concern among survivors. Human sex trafficking is associated with significant and long-term mental health consequences. Research to date has emphasized ways to identify survivors in health care settings. Once identified, however, few specialized services are available to help survivors exit and recover. The current services infrastructure for HST has been compared to the disjointed social response to intimate partner violence before the women's movement helped develop a system of battered women's shelters...
September 2018: Harvard Review of Psychiatry
Michelle S Friedman-Yakoobian, Michelle L West, Kristen A Woodberry, Keira E O'Donovan, Suzannah V Zimmet, Andréa Gnong-Granato, Anthony J Giuliano, Margaret E Guyer, Janine Rodenhiser-Hill, Matcheri S Keshavan, Larry J Seidman
Over the past two decades, increasing attention has been given to the importance of early intervention for psychosis. This article describes the development of the Center for Early Detection, Assessment and Response to Risk (CEDAR), which focuses on early identification and treatment of youth at clinical high risk for psychosis. There are relatively few models in the United States for such programs, and we present our developmental story, focusing mainly on the CEDAR Clinic, as a case study of how such a program can develop...
September 2018: Harvard Review of Psychiatry
Lauren B Gerlach, Ilse R Wiechers, Donovan T Maust
OBJECTIVES: Despite evidence for many potential risks, use of benzodiazepines (BZDs) among older adults is common. The authors evaluated the available evidence for BZD effectiveness and tolerability for use in older adults in three psychiatric conditions for which BZDs are commonly prescribed: insomnia, anxiety disorders, and behavioral and psychological symptoms of dementia. DESIGN: Electronic databases, including PubMed/MEDLINE, were searched to identify articles that (1) included patients ≥50 years of age, (2) focused on patients diagnosed with insomnia, anxiety disorders, or behavioral and psychological symptoms of dementia, and (3) were either a randomized, placebo-controlled trial or a randomized trial comparing a BZD with either another psychotropic medication or psychotherapy...
September 2018: Harvard Review of Psychiatry
Nayla M Khoury, Jacqueline Lutz, Zev Schuman-Olivier
Interoception, or the process of sensing, interpreting, and integrating internal bodily signals, has increasingly been the subject of scientific research over the past decade but is still not well known in clinical practice. The aim of this article is to review clinical treatment interventions that use interoception, to synthesize the current research knowledge, and to identify the gaps where future research is needed. We conducted a comprehensive literature search on randomized, controlled trials that both include interoception in treatment interventions for individuals with psychiatric disorders and measure aspects of interoception using self-report measures...
September 2018: Harvard Review of Psychiatry
Roger S McIntyre, Yena Lee, Nicole E Carmona, Mehala Subramaniapillai, Danielle S Cha, JungGoo Lee, Jae-Hon Lee, Asem Alageel, Nelson B Rodrigues, Caroline Park, Renee-Marie Ragguett, Joshua E Rosenblat, Fahad Almatham, Zihang Pan, Carola Rong, Rodrigo B Mansur
LEARNING OBJECTIVES: After participating in this activity, learners should be better able to:• Characterize cognitive dysfunction in patients with major depressive disorder.• Evaluate approaches to treating cognitive dysfunction in patients with major depressive disorder. ABSTRACT: Cognitive dysfunction is a core psychopathological domain in major depressive disorder (MDD) and is no longer considered to be a pseudo-specific phenomenon. Cognitive dysfunction in MDD is a principal determinant of patient-reported outcomes, which, hitherto, have been insufficiently targeted with existing multimodal treatments for MDD...
September 2018: Harvard Review of Psychiatry
Omar Fattal, Hossam Mahmoud, Lama Bazzi
No abstract text is available yet for this article.
July 2018: Harvard Review of Psychiatry
Lux Ratnamohan, Laurie MacKinnon, Melissa Lim, Richard Webster, Karen Waters, Kasia Kozlowska, Joyanna Silberg, Ricky Greenwald, Monique Ribeiro
No abstract text is available yet for this article.
July 2018: Harvard Review of Psychiatry
Nina F Lewis-Schroeder, Kathryn Kieran, Beth L Murphy, Jonathan D Wolff, Matthew A Robinson, Milissa L Kaufman
First responders are regularly confronted with exposure to traumatic events, including potentially life-threatening situations as well as the grave injuries and deaths of colleagues and civilians. Evidence indicates that the prevalence of posttraumatic stress disorder (PTSD) is substantially higher among first responders than the general population. This article provides information about the outpatient trauma services at McLean Hospital's LEADER (Law Enforcement, Active Duty, Emergency Responder) program to assist clinicians who encounter these first responders in their practices or who are specifically interested in working with this patient population...
July 2018: Harvard Review of Psychiatry
Johannes Graser, Ulrich Stangier
OBJECTIVES: This article presents a brief overview of the empirical evidence of well-established mindfulness interventions and an in-depth review of less-established compassion-based interventions (CBIs) and loving-kindness meditation (LKM). Definitions, cognitive and physiological mechanisms, and methods of assessment are discussed. METHOD: A literature review using the databases Google Scholar, PsycINFO, and PubMed was conducted. RESULTS: Whereas the efficacy of mindfulness-based stress reduction and mindfulness-based cognitive therapy has been documented in many trials, only seven randomized, controlled trials have been completed on CBIs and LKM...
July 2018: Harvard Review of Psychiatry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"