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Archives of Medical Research

Kenzo Hokazono, Fernando Sakata Belizário, Vanessa Portugal, Iara Messias-Reason, Renato Nisihara
BACKGROUND: Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR). AIM OF THE STUDY: To evaluate whether plasma MBL and PTX3 levels are associated with the development of DR and if patients with and without DR can be distinguished. METHODS: The patients were divided into three groups: diabetic without DR; with mild/moderate DR, and with severe/proliferative DR...
June 28, 2018: Archives of Medical Research
Julio Frenk, Octavio Gómez-Dantés
This paper discusses the health challenges faced by countries in Latin America. These challenges have two dimensions: those related to the health needs of populations and those related to the way in which health systems are responding to these needs. The main conclusion is that in order to improve health conditions and move towards universal health coverage, Latin American countries need to design a new generation of policy innovations based on the separation of the three main functions of health systems: financing, delivery and stewardship...
June 27, 2018: Archives of Medical Research
Evelyn G Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Klünder-Klünder, Begoña Segura-Stanford, Julio R Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T Granados Riverón, Leonardo J Mejía-Marín, Norma A Balderrabano-Saucedo, Alejandra Contreras-Ramos, Guadalupe Díaz-Rosas, Rocío Sánchez-Urbina
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. METHODS: 55 mother-child binomials with isolated TAPVC (group I) and 152 healthy mother-child binomials (group II) were included...
June 12, 2018: Archives of Medical Research
Ricardo B Maccioni, José Pablo Tapia, Leonardo Guzman-Martinez
No abstract text is available yet for this article.
May 31, 2018: Archives of Medical Research
Dorota Sienkiewicz, Grażyna Paszko-Patej, Bożena Okurowska-Zawada, Wojciech Kułak
INTRODUCTION: Previous studies of cerebral palsy (CP) suggest that it seasonal variations in the incidence of CP. The purpose of this paper was to compare seasonal variations in the incidence of cerebral palsy (CP) in Podlaskie Province, Poland, between 1990-1999 (study 2005) and 2000-2014 (study 2017) in a retrospective case-controlled study. MATERIALS AND METHODS: Data were obtained from the hospital database. We compared CP births between January 1, 1990, and December 31, 1999, n = 212 (116 boys, 96 girls) and January 1, 2000, and December 31, 2014, n = 205 (114 boys, 91 girls)...
May 23, 2018: Archives of Medical Research
Jeny Salazar-Anguiano, María de Guadalupe Chávez-López, Violeta Zúñiga-García, Javier Camacho, David Elías-Viñas
BACKGROUND AND AIMS: In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical impedance measure technique, and thus potentially improving liver cancer diagnosis. METHODS: Hepatocellular carcinoma (HCC) was induced in male Wistar rats by the administration of diethylnitrosamine (DEN) during 16 weeks...
May 17, 2018: Archives of Medical Research
Vladimir Perovic, Milos Markovic, Milica Kravljaca, Emina Milosevic, Milica Djoric, Vera Pravica, Radomir Naumovic
BACKGROUND AND AIMS: Transplantation is the best treatment option for end stage kidney disease. The most common early complications in post-transplant period are acute rejection (AR) of the graft and delayed graft function (DGF). The underlying mechanisms in these events are heterogeneous and at least in part involve cytokine genes which regulate immune response to allograft. We have investigated whether functional single nucleotide polymorphisms (SNP) in the genes encoding IFN-γ (IFNG), TNF (TNFA), IL-10 (IL10) and p40 subunit of IL-12/IL-23 (IL12B) could predict risk of AR and DGF in kidney allograft recipients...
May 10, 2018: Archives of Medical Research
Mudan Lu, Xuan Chen, Jianping Xiao, Jingying Xiang, Lan Yang, Daozhen Chen
OBJECTIVE: Ovarian cancer is one of the most serious disease in female reproductive system. Platinum is the first-line drug for the treatment of ovarian cancer, while the resistance of platinum drug in clinical hindered the relief ovarian cancer. Our previous study found that decreased FOXO3a might be a poor prognosis in human ovarian cancer. In this research, we study whether FOXO3a was involved in the mechanism of platinum drug resistance. METHODS: The CCK-8 and FACS analysis were used to monitor the survival of ovarian cancer, and the FOXO3a expression was detected by western-blot...
April 28, 2018: Archives of Medical Research
Lilia Carranza-González, Rafael B R León-Cachón, María Antonia González-Zavala, Clara Ríos-Ibarra, Jesús Morlett-Chávez, Celia Sánchez-Domínguez, Ana Cepeda-Nieto, Mauricio Salinas-Santander
BACKGROUND AND AIMS: Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation...
April 25, 2018: Archives of Medical Research
Efrén Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, José Guzmán-Esquivel, Enrique Higareda-Almaraz, Martha Alicia Higareda-Almaraz, Ramón Alberto Sánchez-Piña, Agustin Lugo-Radillo
AIM OF THE STUDY: To assess the cumulative incidence and clinical markers associated with persistent arthralgia (PA) at 12 months from acute chikungunya virus (CHIKV) infection. METHODS: A multicenter retrospective cohort study was conducted in the state of Colima, Mexico, and 217 serologically confirmed cases of CHIKV infection were enrolled. Participants aged 15 years and older were interviewed on 6 months basis from acute illness onset and the main binary outcome was self-reported PA at 12 months...
April 24, 2018: Archives of Medical Research
Emiy Yokoyama, Margarita Chávez-Saldaña, Lorena Orozco, Francisco Cuevas, José Luis Lezana, Rosa María Vigueras-Villaseñor, Julio Cesar Rojas-Castañeda, Daniel Adrian Landero
BACKGROUND: The variation in cystic fibrosis (CF) lung disease not always is explained by the CFTR genotype, so it has become apparent that modifier genes must play a considerable role in the phenotypic heterogeneity of CF, so we investigated the association of allelic variants in modifier genes that modulate the severity of lung function in a group of Mexican patients diagnosed with CF. METHODS: We included 140 CF patients classified according to lung phenotype and analyzed 17 single nucleotide polymorphisms (SNPs) by TaqMan® allelic discrimination...
April 24, 2018: Archives of Medical Research
Ahmad Reza Shahverdi, Faranak Shahverdi, Elnaz Faghfuri, Mohammad Reza Khoshayand, Faranak Mavandadnejad, Mohammad Hossein Yazdi, Mohsen Amini
BACKGROUNDS AND AIMS: Selenium nanoparticles (SeNPs) have been reported to exhibit an inhibitory effect on cancer cells. In the present study, we aimed to compare the in vitro and in vivo effects of SeNPs and folic acid surface-coated selenium nanoparticles (FA@SeNPs) on breast cancer. METHODS: FA@SeNPs and SeNPs were chemically synthesized and characterized with different instrumental techniques. The cytotoxicity of both nanomaterials was evaluated against 4T1 cells...
April 23, 2018: Archives of Medical Research
Simona Iftimie, Anabel García-Heredia, Francesc Pujol-Bosch, Antoni Pont-Salvadó, Ana Felisa López-Azcona, Anna Hernández-Aguilera, Noemí Cabré, Fedra Luciano-Mateo, Isabel Fort-Gallifa, Antoni Castro, Jordi Camps, Jorge Joven
This study provides preliminary information on the usefulness of measuring serum paraoxonase-1 (PON1) concentration and activity (and other inflammatory markers) to predict tumor recurrence in patients with urinary bladder cancer. We studied a total of 39 hospitalized patients in whom the diagnosis of urinary bladder cancer was confirmed by transurethral resection. After five years of follow-up, 29 patients presented with tumor recurrence. As control subjects, we also studied 61 healthy subjects and a further 132 hospitalized patients who had a urinary catheter-related infection due to causes other than cancer...
April 23, 2018: Archives of Medical Research
Sa Xiao, Qiuping Li, Kun Hu, Yu He, Qing Ai, Liuhong Hu, Jialin Yu
BACKGROUND: Exaggerated inflammation that characterizes necrotizing enterocolitis (NEC) is caused by the invasion of pathogens through an immature intestinal barrier. Vitamin A (VA) and retinoic acid (RA) play important roles in the growth of epithelial tissue and in modulating immune function. OBJECTIVE: To investigate the roles of VA and RA in the development of NEC. METHODS: Levels of serum retinol in patients and in a NEC mouse model were detected with high-performance liquid chromatography...
April 23, 2018: Archives of Medical Research
Miriam Rodríguez-Esquivel, Juan Rosales, Rafael Castro, Teresa Apresa-García, Ónix Garay, Pablo Romero-Morelos, Daniel Marrero-Rodríguez, Keiko Taniguchi-Ponciano, Ricardo López-Romero, Héctor Guerrero-Flores, Betsabé Morales, Mónica Mendoza-Rodríguez, Dejanira Mosso-Lara, Itzalia Núñez-Nolasco, Paola Castro-Alba, Sergio E Meza-Toledo, Mauricio Salcedo
BACKGROUND AND AIMS: Different Volatile Organic Compounds (VOCs) obtained from several human fluids (volatolome) has been reported as potential biomarkers for a great variety of diseases including cancer. At present, volatolomic profile data of the female genital area is scarce. METHODS: To identify the VOCs related to the female genitourinary area of healthy and Cervical Cancer (CC)-affected women used a pad, as a non-invasive tool for sample gathering was necessary...
April 19, 2018: Archives of Medical Research
Laura Arcelia Montiel-Cervantes, Elba Reyes-Maldonado, Jaime Garcia-Chavez, Alvaro Hernandez-Caballero, Rubiraida Molina-Aguilar, Miriam America Garcia-Ruiz Esparza, Jorge Vela-Ojeda
BACKGROUND: Acute lymphoblastic leukemia is an aggressive malignant disease with high mortality rates in adults. AIM OF THE STUDY: The expression levels of CD95, active caspase-3, and Bcl-2 were determined in 111 patients with de novo acute lymphoblastic leukemia (ALL) and correlated with overall survival (OS) and disease-free survival (DFS). METHODS: The immunophenotyped ok leukemia and the expression of CD95, active caspase-3, and Bcl-2, were determined by flow cytometry...
April 18, 2018: Archives of Medical Research
Iván de Jesús Ascencio-Montiel
BACKGROUND: Little is known about diabetes-related major lower extremity amputations (DMLEA) burden in México. AIM OF THE STUDY: To describe DMLEA hospitalization rates, in-hospital survival rates, characteristics associated with all-cause in-hospital mortality and direct costs of hospitalization during the 2005-2015 period, in the two principal Health Institutions in Mexico: the Mexican Institute of Social Security (IMSS) and the Ministry of Health (MoH). METHODS: A secondary data analysis was conducted using hospital discharge information obtained from administrative databases...
April 18, 2018: Archives of Medical Research
Chan-Hee Jung, Sang Hee Jung, Bora Lee, Dukhyun Choi, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
BACKGROUND AND AIM: To quantify the differential contribution of sleep duration on fasting plasma glucose level by traditional regular daytime work and shift work in subjects without diabetes. METHODS: Self-reported sleep duration and work type and timing were determined in a cross-sectional sample of 9123 participants aged 20-65 years from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2015. Those who responded that they worked between 6 am and 6 pm were classified as "traditional regular daytime workers; "those who worked in the afternoon, at night, or in several types of shift work were classified as "shift workers...
April 17, 2018: Archives of Medical Research
Mauro Maniscalco, Andrea Motta
Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing...
April 17, 2018: Archives of Medical Research
Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel Gómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar
BACKGROUND: Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. OBJECTIVE: Evaluate whether plasma copeptin levels may be used as a biomarker of decline renal function in patients with T2DM. RESEARCH DESIGN AND METHODS: A total of 480 patients with T2DM and different stages of CKD were included...
April 14, 2018: Archives of Medical Research
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