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Archives of Medical Research

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https://www.readbyqxmd.com/read/30448236/inhibition-of-sphk2-stimulated-hepatic-gluconeogenesis-associated-with-dephosphorylation-and-deacetylation-of-stat3
#1
Jihong Yuan, Jiayun Qiao, Biao Mu, Laixiang Lin, Ling Qiao, Lihui Yan, Yanan Shi
BACKGROUND: Sphingosine kinase (SphK) is considered as a potential target for developing novel therapeutics of cancer and other diseases including diabetes. As the major SphK isoform in the liver, much less is known the role of SphK2 involved in regulating hepatic glucose metabolism. METHOD: In this study, RNA interference, real time RT-PCR, western blot and immunoprecipitation method was used to investigate the regulation of SphK2 in hepatic glucose metabolism...
November 15, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30446246/reduction-of-no-reflow-with-a-loading-dose-of-atorvastatin-before-primary-angioplasty-in-patients-with-acute-st-myocardial-infarction
#2
Rosalba C García-Méndez, Eduardo Almeida-Gutierrez, Leonor Serrano-Cuevas, Jesús Salvador Sánchez-Díaz, Martín Rosas-Peralta, Jose Alberto Ortega-Ramirez, Jose Antonio Palomo-Villada, Irma Isordia-Salas, Rosa Marisol Alonso-Bravo, Gabriela Borrayo-Sanchez
BACKGROUND: No reflow defined as an altered myocardial reperfusion and failure at microvascular level is a frequent complication in acute myocardial infarction that attenuates beneficial effect of reperfusion therapy leading to poor outcomes. There is not enough evidence to support that previous use of statins improves coronary flow in patients undergoing primary percutaneous coronary intervention (PCI). AIM OF STUDY: To determine if a loading dose of 80 mg of atorvastatin before primary angioplasty reduces the frequency of no reflow, hs-CRP, IL6 intracoronary levels, and major combined cardiovascular events at 30 d...
November 13, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30414710/clinical-interests-of-circulating-tumor-dna-in-oncology
#3
REVIEW
Claire Franczak, Pierre Filhine-Tressarieu, Julien Broséus, Pauline Gilson, Jean-Louis Merlin, Alexandre Harlé
Genetic alterations in tumors, as predictor of response to targeted-therapies or as prognostic markers, are clinically relevant to determine adequate therapeutic management. Tumor biopsy is currently the golden standard for somatic alterations assessment, but this approach is invasive and does not consider tumor heterogeneity. In various body fluids like plasma, somatic mutations have been identified. Circulating tumor DNA (ctDNA) holds promises in tumor burden monitoring or malignancies early detection. Since allele frequencies of circulating somatic mutations are low, highly sensitive novel assays have been developed to allow the investigation of the tumor genome, leading to the emergence of the "liquid biopsy" concept...
November 7, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30409503/geniposide-and-gentiopicroside-suppress-hepatic-gluconeogenesis-via-regulation-of-akt-foxo1-pathway
#4
Shao-Qing Yang, Ye-Dan Chen, Heng Li, Xian Hui, Wen-Yun Gao
BACKGROUND: Hepatic gluconeogenesis plays an important role in regulating fasting plasma glucose levels and is a target of anti-diabetic drugs. Several kinds of iridoid glucosides exhibit hypoglycemic effect, whereas the mechanism was not clear. AIM OF THE STUDY: In this study, the effects of geniposide and gentiopicroside, two natural iridoid glucosides, on hepatic gluconeogenesis were investigated. METHODS: Glucose uptake assay, MTT assay, q-PCR, luciferase assay and western blot assay were performed to investigate the pharmacological effect of geniposide and gentiopicroside on human liver cell line L02...
November 5, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30401587/predicting-human-mirna-like-sequences-within-human-papillomavirus-genomes
#5
Denisse A Gutiérrez, Armando Varela-Ramírez, Miriam Rodríguez-Esquivel, Mónica G Mendoza-Rodríguez, Jorge T Ayala-Sumuano, David Pineda, Efraín Garrido-Guerrero, Florinda Jiménez-Vega, Saúl Aguilar, Miguel Quiñones, María J Nambo, Pedro Chávez-Olmos, Keiko Taniguchi-Ponciano, Daniel Marrero-Rodriguez, Pablo Romero-Morelos, Joanna P Castro, Cindy Bandala, Andrea Carrillo-Romero, Beatriz González-Yebra, Mauricio Salcedo
BACKGROUND: This study presents a prediction of putative miRNA within several Human Papillomavirus (HPV) types by using bioinformatics tools and a strategy based on sequence and structure alignment. Currently, little is known about HPV miRNAs. METHODS: Computational methods have been widely applied in the identification of novel miRNAs when analyzing genome sequences. Here, ten whole-genome sequences from HPV-6, -11, -16, -18, -31, -33, -35, -45, -52, and -58 were analyzed...
November 3, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30342848/antioxidant-activity-and-protective-effect-of-carob-honey-in-ccl-4-induced-kidney-and-liver-injury
#6
Redouan El-Haskoury, Noori Al-Waili, Zineb Kamoun, Mohamed Makni, Hamza Al-Waili, Badiaa Lyoussi
BACKGROUND/AIM: Various honey samples exhibited protective effect against drug and chemical induced toxicity. The study was designed to determine the antioxidant content and activity of carob honey and to investigate its hepato-renal protective effect in carbon tetrachloride (CCl4) induced kidney and liver injury in rats. MATERIAL AND METHODS: Phenolic, flavone and flavonol in carob honey were quantified. DPPH, ABTS•+, ferric reducting antioxidant power, and total antioxidant activity were used to evaluate the antioxidant activity...
October 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30342847/association-studies-of-hspa1a-and-hspa1l-gene-polymorphisms-with-schizophrenia-in-the-polish-population
#7
Malgorzata Kowalczyk, Krzysztof Kucia, Aleksander Owczarek, Renata Suchanek-Raif, Wojciech Merk, Monika Paul-Samojedny, Jan Kowalski
BACKGROUND: Schizophrenia is a severe psychiatric disorder with a strong genetic component. The HSP70 chaperones are particularly interesting in terms of schizophrenia, especially with regard to neurodevelopmental hypothesis, because they are critical regulators in normal neural physiological function as well as in cell stress responses. AIM OF THE STUDY: The present study aimed to determine whether genetic variants in the HSPA1A (rs1008438, rs562047) and HSPA1L (rs2075800) genes are associated with the risk of paranoid schizophrenia and the clinical presentation of the disease...
October 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30342846/varicella-zoster-virus-in-cerebrospinal-fluid-at-relapses-of-multiple-sclerosis-is-infective-in-vitro
#8
Olivia Hernández-González, Adolfo Martínez-Palomo, Julio Sotelo, Bibiana Chávez-Munguía, Graciela Ordoñez, Daniel Talamás-Lara, Benjamin Pineda, José de Jesús Flores-Rivera, Martha Espinosa-Cantellano
BACKGROUND: We have reported the presence of varicella-zoster virus (VZV) DNA and viral particles in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation. It is not known whether these viruses are infective. AIM: To determine whether the VZV found in CSF of MS patients in exacerbation phase are infective. METHODS: VZV found in CSF of MS patients was quantified by qPCR. Vero E6 cell cultures were incubated with CSF of five MS cases positive for VZV DNA, containing herpes-like viral particles...
October 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30314650/synergistic-interaction-of-rutin-and-silibinin-on-human-colon-cancer-cell-line
#9
Sana Nafees, Syed Hassan Mehdi, Mohammad Zafaryab, Bushra Zeya, Tarique Sarwar, Moshahid Alam Rizvi
AIM OF THE STUDY: Rutin and Silibinin are active flavonoid compounds, well-known for possessing multiple biological activities. We have studied how Rutin and Silibinin in combination modulate wide range intracellular signaling cascades as evidenced by in-vitro research. Data obtained from preclinical studies provide evidence to be supportive to bridge basic and translational studies. METHODS: In this study, cytotoxic effect of Rutin and Silibinin individually and in combination on the viability of colon cancer cell line (HT-29) was revealed using the MTT assay...
October 9, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30309698/response-to-chikungunya-in-bolivia-still-a-neglected-disease
#10
LETTER
Efrén Murillo-Zamora, Oliver Mendoza-Cano
No abstract text is available yet for this article.
October 8, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30301583/vaccination-status-and-another-preventive-measures-in-medical-school-big-needs-and-opportunities
#11
EDITORIAL
Germán Fajardo Dolci
No abstract text is available yet for this article.
October 6, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30292339/association-between-norepinephrine-transporter-gene-rs2242446-rs5569-polymorphisms-and-risk-of-major-depressive-disorder-a-meta-analysis
#12
Huan Rui, Hongjia Qian, Muhua Shi, Guorui Zhang, Liqun Wang
BACKGROUND AND AIMS: The association between norepinephrine transporter (NET) gene polymorphisms and the risk of major depressive disorder (MDD) has been investigated extensively, but with contradictory findings. MATERIALS/METHODS: To clarify such contradiction, a comprehensive meta-analysis was conducted by searching PubMed, EMBASE, Web of Science and China Knowledge Resource Integrated Database. Odd ratios (ORs) and 95% confidence intervals (Cis) were used to evaluate the strength of the association...
October 3, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30274913/association-between-mir-149-gene-rs2292832-polymorphism-and-risk-of-gastric-cancer-a-case-control-study
#13
Lili Zhang, Qingna Liu, Fan Wang
BACKGROUND AND AIMS: Accumulating evidence suggested that microRNA (miRNA) genes take part in different processes associated with gastric cancer (GC). The single nucleotide polymorphisms (SNPs) located on miRNA sequences may affect the interaction with their target mRNAs and consequently the genetic susceptibility to GC. MATERIALS/METHODS: A hospital-based case-control study with 320 cases and 354 controls was conducted to investigate the association between miR-149 gene rs2292832 polymorphism and GC susceptibility in a Chinese Han population...
September 28, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30274912/effect-of-fat-graft%C3%A4-ng-on-postoperat%C3%A4-ve-intraabdom%C3%A4-nal-adhesions-on-a-rat-model
#14
Asudan Tugce Bozkurter Cil, Ilhami Oguzhan Aydogdu
BACKGROUND: We aimed to evaluate the effect of fat grafting on postoperative intraabdominal adhesions by promoting mesothelial healing on a rat model. METHODS: Thirty Wistar albino rats were grouped as control and fat grafted group. They all underwent laparotomy, anterior cecal wall abrasion and peritoneal injury. On postoperative day 14, all surviving rats were sacrificed and adhesions, fibrosis and inflammation were graded using quantitative scoring systems. RESULTS: Fat grafting significantly reduced adhesion formation compared to the control group (p < 0...
September 28, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30269966/chikungunya-in-bolivia-still-a-neglected-disease
#15
LETTER
Juan Pablo Escalera-Antezana, David R Murillo-García, Alfonso J Rodriguez-Morales
No abstract text is available yet for this article.
September 27, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30269965/roles-of-reduced-nitric-oxide-in-liver-cell-apoptosis-inhibition-during-liver-damage
#16
REVIEW
Ying-Yi Wang, Meng-Ting Chen, Hui-Min Hong, Ying Wang, Qian Li, Hui Liu, Mei-Wen Yang, Fen-Fang Hong, Shu-Long Yang
Hepatic injury is a major event in liver surgery and may lead to liver cell apoptosis. Nitric oxide (NO) is an unstable, carbon-centered radical with a short half-time and a key role in molecular signaling. Increasing evidence demonstrates that NO plays an important role in the liver cell apoptosis caused by hepatic ischemia reperfusion (IR) injury and other liver damage. Our recent article summarized the association between elevated nitric oxide levels and hepatic cell apoptosis during liver injury. This article reviews the newest research progress for the relationship between decreased nitric oxide levels and hepatic cell apoptosis inhibition during liver injury...
September 27, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30268704/promoter-polymorphisms-of-tnf-%C3%AE-gene-1031-t-c-863-c-a-857-c-t-308-g-a-as-a-risk-factor-for-schizophrenia
#17
Renata Suchanek-Raif, Paweł Raif, Małgorzata Kowalczyk, Monika Paul-Samojedny, Krzysztof Kucia, Wojciech Merk, Jan Kowalski
BACKGROUND/AIMS: The latest data showed a link between mental disorders and altered immune function. Schizophrenia is a multifactorial disease with numerous changes in the immunological system. The TNF-α gene is a strong candidate for schizophrenia susceptibility. The focus of this paper were the -1031 T/C, -863 C/A, -857 C/T, -308 G/A single nucleotide polymorphisms (SNPs) of the TNF-α gene. METHODS: We conducted a case-control study of 401 patients with schizophrenia and 606 healthy subjects...
September 26, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30268703/decompensated-chronic-heart-failure-reduces-plasma-l-carnitine
#18
Sheila Moreira da Silva Guimarães, Wanise Maria de Souza Cruz, Guilherme de Souza Weigert, Fernanda Bertão Scalco, Alexandre Siciliano Colafranceschi, Marcia Gonçalves Ribeiro, Gilson Teles Boaventura
The heart has an intense aerobic metabolism and is among the most metabolically active organs in the body. Its tissue stores fatty acid, the main energetic substrate, and requires high concentrations of plasma L-carnitine. This nutrient is essential in the transport of fatty acids to the mitochondria to generate energy and maintain the proper concentration of coenzyme A free. In decompensated chronic heart failure metabolic changes, associated with inflammation, alter the metabolism of L-carnitine and compromise cardiac energy metabolism...
September 26, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30266531/a-novel-magnetic-nanoparticle-for-early-detection-of-amyloid-plaques-in-alzheimer-s-disease
#19
Jiaqi Zeng, Jiaqi Wu, Minghua Li, Peijun Wang
Early diagnosis of Alzheimer's disease (AD) remains challenging even with the assistance of imaging. Radiation exposure limits the application of positron emission tomography (PET) for amyloid imaging. Magnetic resonance imaging (MRI) offers superior spatial resolution without the disadvantage of radiation exposure. We developed Mn0.6 Zn0.4 Fe2 O4 (MZF) modified by Pittsburgh compound B (PiB) to specifically bind to amyloid plaques. Coated with amphiphilic nanopolymer 6sPCL-b-P(MEO2 MA-co-OEGMA), PiB-MZF was stable, biocompatible, and approximately 100 nm in size...
September 26, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30266532/discriminatory-accuracy-of-preeclampsia-risk-factors-in-a-primary-care
#20
Hid Felizardo Cordero-Franco, Ana María Salinas-Martínez, Tania Abigail García-Alvarez, Eloísa Verónica Maldonado-Sánchez, Francisco Javier Guzmán-de la Garza, Alvaro Mathiew-Quirós
BACKGROUND: Although it is common to use risk factors in the screening for preeclampsia, they do not always accurately identify patients who truly have this condition. AIM OF THE STUDY: To determine the discriminatory accuracy of known preeclampsia risk factors, both individually and in combination. METHODS: We studied patients undergoing prenatal care who were diagnosed with preeclampsia or eclampsia (n = 160 cases) in primary care and those who were not (n = 430 controls)...
September 25, 2018: Archives of Medical Research
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