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Archives of Medical Research

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https://www.readbyqxmd.com/read/27986131/response-differential-immune-profiles-in-two-pandemic-influenza-a-h1n1-pdm09-virus-waves-at-pandemic-epicenter
#1
LETTER
Constantino López-Macías, Eduardo Ferat-Osorio, Lourdes Arriaga-Pizano
No abstract text is available yet for this article.
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986130/influenza-and-immune-profile
#2
LETTER
Jose Luis Sandoval-Gutierrez
No abstract text is available yet for this article.
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986129/ischemic-postconditioning-before-percutaneous-coronary-intervention-for-acute-st-segment-elevation-myocardial-infarction-reduces-contrast-induced-nephropathy-and-improves-long-term-prognosis
#3
Yun-Yun Wang, Tong Li, Ying-Wu Liu, Yu Wang, Xiao-Min Hu, Wen-Qing Gao, Peng Wu, Xin Li, Wen-Jin Peng, Wei Gao, Guang-Dong Yu, Bo-Jiang Liu
BACKGROUND AND AIMS: Contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) is one of the major adverse outcomes affecting the prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). Ischemic postconditioning prior to PCI (pre-PCI) in patients with STEMI is hypothesized to be protective against CIN after PCI. METHODS: A total of 251 patients with STEMI were randomized into two groups: ischemic postconditioning group (n = 123, age, 61...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986128/high-thyroid-stimulating-hormone-levels-increase-proinflammatory-and-cardiovascular-markers-in-patients-with-extreme-obesity
#4
Jaime Héctor Gómez-Zamudio, Victoria Mendoza-Zubieta, Aldo Ferreira-Hermosillo, Marío Antonio Molina-Ayala, Adán Valladares-Sálgado, Fernando Suárez-Sánchez, Jose de Jesús Peralta-Romero, Miguel Cruz
BACKGROUND AND AIMS: Obesity is an important health problem worldwide and many studies have suggested a relationship between obesity and thyroid function, with controversial results. Interestingly, high TSH levels have been involved with the presence of inflammatory state and risk for developing cardiovascular diseases in hypothyroid and obese patients. The aim in this work was to determine the prevalence of hypothyroidism in patients with extreme obesity and to determine whether their TSH levels were related to increased serum levels of inflammatory and cardiovascular markers...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986127/irisin-and-myostatin-levels-in-patients-with-graves-disease
#5
Mehmet Muhittin Yalcin, Mujde Akturk, Yusuf Tohma, Ethem Turgay Cerit, Alev Eroglu Altinova, Emre Arslan, Ilhan Yetkin, Fusun Balos Toruner
BACKGROUND AND AIMS: Skeletal muscle system, which is one of the primary targets for thyroid hormones, has an important role in energy metabolism. Some myokines such as irisin and myostatin have considerable effects on energy metabolism in addition to the musculoskeletal system. Our aim was to investigate circulating irisin and myostatin levels in patients with Graves' Disease (GD). METHODS: This study included 41 patients with GD who were in overt hyperthyroid status and 44 healthy subjects...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986126/aberrant-cpg-island-shore-region-methylation-of-cav1-is-associated-with-tumor-progression-and-poor-prognosis-in-gastric-cardia-adenocarcinoma
#6
Yan-Li Guo, Tie-Nian Zhu, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Yu-Jie Cui, Rui-Jing Zhao
BACKGROUND AND AIMS: Caveolin-1 (CAV1) is a multifunctional scaffolding protein and plays an important role in tumorigenesis. However, the epigenetic changes of CAV1 in gastric cardia adenocarcinoma (GCA) have not been investigated so far. The purpose of this study was to clarify the contribution of critical CpG sites in CAV1 to progression/prognosis of GCA and to further elucidate the effect of critical CpG sites on the ectopic expression of β-catenin in GCA. METHODS: Methylation-specific polymerase chain reaction (MSP) and bisulfite genomic sequencing (BGS) methods were, respectively, applied to examine the methylation status of CAV1...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986125/evaluation-of-circulating-tumor-cells-in-predicting-therapeutic-response-in-small-cell-lung-cancer-patients
#7
Xu Wang, Kewei Ma, Yizhuo Wang, Hua He, Ji-Fan Hu, Wei Li
BACKGROUND AND AIMS: Circulating tumor cells (CTCs) have prognostic significance in patients with metastatic cancer, but their utility in predicting the response to tumor therapy is unknown. This study examined the correlation of CTCs with the therapeutic response in small cell lung cancer (SCLC). METHODS: Clinical and pathological data from 96 SCLC patients were evaluated in this study. CellSearch kits were used to detect CTCs in peripheral blood samples. Statistical analysis was performed using Fisher exact test and Mann-Whitney U test...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986124/long-noncoding-rna-highly-up-regulated-in-liver-cancer-predicts-unfavorable-outcome-and-regulates-metastasis-by-mmps-in-triple-negative-breast-cancer
#8
Feng Shi, Fang Xiao, Ping Ding, Hong Qin, Ruixue Huang
BACKGROUND AND AIMS: Long noncoding RNA (lncRNA) highly up-regulated in liver cancer (HULC) is the first identified lncRNA highly expressed in hepatocellular carcinoma and acts as an oncogenic lncRNA. However, the significance of HULC in triple-negative breast cancer (TNBC) is still unclear. Our purpose is to explore the clinical significance and biological function of HULC in TNBC. METHODS: Expression of HULC in TNBC tissues and cell lines was measured and the association between HULC expression and clinicopathological factors was analyzed...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986123/effects-of-castanospermine-on-inflammatory-response-in-a-rat-model-of%C3%A2-experimental-severe-acute-pancreatitis
#9
Yu-Pu Hong, Chen Chen, Wen-Yi Guo, Liang Zhao, Fang-Chao Mei, Ming-Wei Xiang, Wei-Xing Wang
BACKGROUND AND AIMS: Acute pancreatitis (AP) is an acute inflammatory disorder characterized by autodigestion of pancreatic tissue resulting in local pancreatic injury or systemic inflammatory response. Castanospermine (CAST) is an alkaloid from the Castanospermum australe, known as an anti-inflammatory agent and immunosuppressant in animal experiments. However, whether CAST can attenuate AP remains unclear. This study investigated the effects of CAST on sodium taurocholate (STC)-induced severe acute pancreatitis (SAP) in rats and the pertinent mechanism...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986122/vitamin-b12-deficiency-across-three-generations-adversely-influences-long-chain-polyunsaturated-fatty-acid-status-and-cardiometabolic-markers-in-rats
#10
Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi
BACKGROUND AND AIMS: Vitamin B12 and omega-3 fatty acid deficiency is prevalent in the vegetarian population and is associated with adverse pregnancy outcomes and cardiometabolic risk. The present study investigates the long-term effects of vitamin B12 deficiency/supplementation in the presence of omega-3 fatty acids on cardiometabolic profile and long-chain polyunsaturated fatty acid levels (LCPUFA) in the F3 generation offspring. METHODS: Three generations of rats were fed the following diets: control; vitamin B12 deficient; vitamin B12 supplemented; vitamin B12 deficient + omega-3 fatty acid supplemented; vitamin B12 + omega-3 fatty acid supplemented...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986121/intracellular-progesterone-receptor-mediates-the-increase-in-glioblastoma-growth-induced-by-progesterone-in-the-rat-brain
#11
Liliana Germán-Castelán, Joaquín Manjarrez-Marmolejo, Aliesha González-Arenas, Ignacio Camacho-Arroyo
BACKGROUND AND AIMS: Progesterone (P) is a steroid hormone involved in the development of several types of cancer including astrocytomas, the most common and malignant brain tumors. We undertook this study to investigate the effects of P on the growth and infiltration of a tumor caused by the xenotransplant of U87 cells derived from a human astrocytoma grade IV (glioblastoma) in the cerebral cortex of male rats and the participation of intracellular progesterone receptor (PR) on these effects...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27986120/copb2-is-upregulated-in-prostate-cancer-and-regulates-pc-3-cell-proliferation-cell-cycle-and-apoptosis
#12
Yuanyuan Mi, Menglei Yu, Lifeng Zhang, Chuanyu Sun, Bingbing Wei, Weihong Ding, Yingfeng Zhu, Jianmin Tang, Guowei Xia, Lijie Zhu
BACKGROUND AND AIMS: Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers. Coatomer complex I (COPI)-coated vesicles are involved in the transport between endoplasmic reticulum (ER) and Golgi complex. Several studies indicated that some subunits of COPI were correlated with the cell proliferation of malignant tumors. The present study focused on the function of coatomer protein complex subunit β 2 (COPB2), one of seven proteins in COPI, in prostate cancer (PCa)...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751377/malignant-pleural-mesothelioma-the-need-to-move-from-research-to-clinical-practice
#13
Caterina Ledda, Venerando Rapisarda
No abstract text is available yet for this article.
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751376/the%C3%A2-1858%C3%A2-c-t-polymorphism-in-the-ptpn22-gene-is-associated-with-cystic-fibrosis-patients-in-northeast-mexico
#14
Mauricio A Salinas-Santander, Elizabeth Bazan-Mendoza, Marisol Espinoza-Ruiz, Rocio Ortiz-Lopez, Adriana Bustamante, Celia N Sanchez-Dominguez
Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population, but it has also been widely diagnosed in the Mexican population. Production of viscous secretions affects the secretory epithelia and the respiratory condition usually leads to death. The relationship between the CFTR genotype and the disease phenotype is not well understood. Other risk factors such as genetic and autoimmune influence the development of this disease. We analyzed the PTPN22 R620W polymorphism (+1858 C/T, rs2476601) in 78 DNA samples from CF patients and 232 healthy controls from northeast Mexico using the polymerase chain reaction-restriction fragment length (PCR-RFLP) method...
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751375/monitoring-of-cd8-t-cell-activity-in-mtor-inhibitor-treated-cancer-patients-for-successful-immunotherapy
#15
Alireza Bolourian, Zahra Mojtahedi
Mammalian target of rapamycin (mTOR) inhibitors are strong anti-tumor drugs; however, they have adverse immunosuppressive side effects in some cancer patients. Animal studies have provided evidence that mTOR inhibitors improved tumor-specific T-cells adoptive transfer in which the quality of CD8+ T-cells is a major factor for predicting success. Interestingly, mTOR inhibitors are capable of stimulating cytotoxic CD8+ T-cell if their dose/duration is adjusted. Rapamycin-induced CD8+ T-cells have also been associated with tumor immunity in animal models...
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751374/diagnostic-accuracy-of-several-electrocardiographic-criteria-for-the-prediction-of-atrioventricular-nodal-reentrant-tachycardia
#16
Juliana Filgueiras Medeiros, Fábio Martins Nardo-Botelho, Lara Cristina Felix-Bernardes, Lucas Hollanda-Oliveira, Lucas Bassolli de Oliveira-Alves, Ênia Lúcia-Coutinho, Cristiano Dietrich, Adriano Caixeta, Jose Marconi Almeida-de-Sousa, Ântonio Carlos-Carvalho, Cláudio Cirenza, Ângelo Amato Vicenzo-de-Paola
BACKGROUND AND AIMS: Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common form of paroxysmal supraventricular tachycardia (SVT) whose diagnosis can be strongly suspected based on the surface eletrocardiogram alone. The purpose of this study is to determine the diagnostic accuracy of several electrocardiographic (ECG) criteria for the prediction of AVNRT. METHODS: Between November 2010 and January 2014, a total of 256 patients who underwent electrophysiological testing (EP) with regular, paroxysmal and narrow QRS complex tachycardia were prospectively enrolled...
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751373/factors-associated-with-frontotemporal-dementia-in-china-a-cross-sectional-study
#17
Hui Chen, Shuai Liu, Miaoyan Zheng, Lu Ji, Tianfeng Wu, Guowei Huang, Yong Ji
BACKGROUND AND AIMS: There is a growing focus on frontotemporal dementia (FTD). However, compared with other major dementias, very little is known about the factors associated with FTD. The present study evaluated candidate factors associated with FTD in the Chinese population. METHODS: One hundred eight elderly patients (36 diagnosed with FTD and 72 controls) of the Neurology Central Hospital of Tianjin (China), were diagnosed by neurologists, and recruited for the study between November 2011 and November 2014...
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751372/fasting-triglycerides-and-glucose-index-as-a-diagnostic-test-for-insulin-resistance-in-young-adults
#18
Fernando Guerrero-Romero, Rafael Villalobos-Molina, J Rafael Jiménez-Flores, Luis E Simental-Mendia, René Méndez-Cruz, Miguel Murguía-Romero, Martha Rodríguez-Morán
BACKGROUND AND AIMS: Although the Glucose and Triglyceride levels (TyG) index is useful for identification of insulin resistance (IR) in different ethnic groups, it has not been evaluated in young adults. We undertook this study to evaluate the TyG index as a diagnostic test for IR in young adults. METHODS: A total of 5,538 healthy young adults, 3,795 (68.5%) non-pregnant women and 1,743 (31.5%) men, with an average age of 19.2 ± 1.4 years, were enrolled in a population-based cross-sectional study...
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751371/impaired-word-and-face-recognition-in-older-adults-with-type-2-diabetes
#19
Nicola Jones, Leigh M Riby, Michael A Smith
BACKGROUND AND AIMS: Older adults with type 2 diabetes mellitus (DM2) exhibit accelerated decline in some domains of cognition including verbal episodic memory. Few studies have investigated the influence of DM2 status in older adults on recognition memory for more complex stimuli such as faces. In the present study we sought to compare recognition memory performance for words, objects and faces under conditions of relatively low and high cognitive load. METHODS: Healthy older adults with good glucoregulatory control (n = 13) and older adults with DM2 (n = 24) were administered recognition memory tasks in which stimuli (faces, objects and words) were presented under conditions of either i) low (stimulus presented without a background pattern) or ii) high (stimulus presented against a background pattern) cognitive load...
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27751370/diagnosis-of-sepsis-with-cell-free-dna-by-next-generation-sequencing-technology-in-icu-patients
#20
Yun Long, Yinxin Zhang, Yanping Gong, Ruixue Sun, Longxiang Su, Xin Lin, Ao Shen, Jiali Zhou, Zhuoma Caiji, Xinying Wang, Dongfang Li, Honglong Wu, Hongdong Tan
BACKGROUND AND AIMS: Bacteremia is a common serious manifestation of disease in the intensive care unit (ICU), which requires quick and accurate determinations of pathogens to select the appropriate antibiotic treatment. To overcome the shortcomings of traditional bacterial culture (BC), we have adapted next-generation sequencing (NGS) technology to identify pathogens from cell-free plasma DNA. METHODS: In this study, 78 plasma samples from ICU patients were analyzed by both NGS and BC methods and verified by PCR amplification/Sanger sequencing and ten plasma samples from healthy volunteers were analyzed by NGS as negative controls to define or calibrate the threshold of the NGS methodology...
July 2016: Archives of Medical Research
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