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Archives of Medical Research

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https://www.readbyqxmd.com/read/28625327/response-high-thyroid-stimulating-hormone-levels-increase-proinflammatory-and-cardiovascular-markers-in-patients-with-extreme-obesity
#1
LETTER
Jaime Héctor Gómez-Zamudio, Victoria Mendoza-Zubieta, Aldo Ferreira-Hermosillo, MarÍo Antonio Molina-Ayala, Adán Valladares-Sálgado, Fernando Suárez-Sánchez, Jose De Jesús Peralta-Romero, Miguel Cruz
No abstract text is available yet for this article.
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625326/high-thyroid-stimulating-hormone-levels-increase-proinflammatory-and-cardiovascular-markers-in-patients-with-extreme-obesity-methodological-issues
#2
LETTER
Erfan Ayubi, Saeid Safiri
No abstract text is available yet for this article.
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625325/importance-of-cd117-in-the-assignation-of-a-myeloid-lineage-in-acute-leukemias
#3
Alan Pomerantz, Sergio Rodríguez-Rodríguez, Roberta Demichelis-Gómez, Georgina Barrera-Lumbreras, Olga V Barrales-Benítez, María José Díaz-Huízar, Monica Goldberg-Murow, Xavier López-Karpovitch, Álvaro Aguayo
The correct classification of acute leukemias (AL) is an essential part in the evaluation of any patient with this disease. Historically, CD117 has been an important asset in the diagnosis of patients with mixed-phenotype acute leukemia (MPAL). In an attempt to simplify the diagnosis of MPAL with fewer and more lineage specific markers, the World Health Organization (WHO) proposed in 2008 a new criteria for the diagnosis of this type of AL, which excluded CD117 from the myeloid markers that are utilized to diagnose MPAL...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625324/esr2-genetic-variants-and-combined-oral-contraceptive-use-associated-with-the-risk-of-stroke
#4
Zhenlin Xu, Ying Li, Xiaoping Huang, Wei Shen, Jianling Bai, Chong Shen, Yang Zhao
BACKGROUND AND AIM: There is accumulating evidence suggesting an important role of estrogen receptor-β in the development of cardiovascular disease. The present study aims to investigate the relationship of estrogen receptor β gene (ESR2) polymorphisms with stroke risk in Chinese women, and further evaluate the gene-environment interaction of ESR2 and combined oral contraceptive (COC) use on stroke risk. METHODS: A case-control study was conducted with 446 first-ever stroke patients and 864 control subjects recruited from our prospective female cohort...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625323/assessment-of-sodium-and-potassium-intake-by-24%C3%A2-h-urinary-excretion-in-a-healthy-mexican-cohort
#5
Maite Vallejo, Eloisa Colín-Ramírez, Susana Rivera Mancía, Raúl Cartas Rosado, Magdalena Madero, Oscar Infante Vázquez, Jesús Vargas-Barrón
BACKGROUND AND AIMS: A high dietary sodium intake and a low potassium intake are associated with adverse cardiovascular health. Data on these nutrients consumption in Mexico is limited. The aim of this study was to assess sodium and potassium intake by 24 h urinary excretion in a clinically healthy Mexican population. We additionally explored their association with blood pressure. METHODS: 711 clinically healthy participants aged 20-50 years old recruited in the Tlalpan 2020 cohort from September 2014-December 2015, were included in this cross-sectional analysis...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625322/effect-of-b-vitamins-from-diet-on-hypertension
#6
Ruru Liu, Baibing Mi, Yaling Zhao, Qiang Li, Hong Yan, Shaonong Dang
BACKGROUND: In western populations, a higher level of dietary B vitamins intake has been associated with a lower risk of hypertension. However, data in Chinese is limited, whose B vitamins consumption is low and rates of hypertension are high. AIM OF THE STUDY: To investigate whether the three B vitamins are associated with hypertension in rural Chinese. METHODS: Cross-sectional survey among 2241 rural Chinese aged 18-80 years was conducted in northwestern China in 2010...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625321/catechol-o-methyltransferase-gene-polymorphism-val158met-and-development-of-pre-eclampsia
#7
Ali Taravati, Fatemeh Tohidi, Mehrnaz Moniri, Kasra Kamali
OBJECTIVES: Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. The present meta-analysis was done to elucidate the association of COMT Val158Met polymorphism with pre-eclampsia among pregnant women. METHODS: A literature search was conducted in electronic databases including PubMed, Scopus, Elsevier, Springer and Google Scholar to find eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals were calculated under dominant, recessive, co-dominant, and allelic models...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625320/expression-of-jagged1-notch3-signaling-pathway-and-their-relationship-with-the-tumor-angiogenesis-in-tnbc
#8
Siliang Xue, Lang He, Xiao Zhang, Jin Zhou, Fanghua Li, Xiaoshan Wang
BACKGROUND AND AIMS: Jagged1/Notch3 signaling pathway plays a key role in angiogenesis of breast cancer, but little is known in TNBC. This study was designed to investigate the expression of Jagged1/Notch3 mRNA and protein in TNBC, analyze their correlations with clinicopathological characteristics and prognosis. Moreover, the interrelationship among Jagged1/Notch3 and VEGF was initially evaluated. METHODS: Jagged1/Notch3 mRNA and protein expression levels were determined by Q-RT-PCR and Western blotting...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625319/polymorphic-variants-rs3088442-and-rs2292334-in-the-organic-cation-transporter-3-oct3-gene-and-susceptibility-against-type-2-diabetes-role-of-their-interaction
#9
Abdolkarim Mahrooz, Ahad Alizadeh, Mohammad Bagher Hashemi-Soteh, Maryam Ghaffari-Cherati, Seyyedeh Raheleh Hosseyni-Talei
AIMS: In this study, we investigated whether two common variants (rs3088442G>A and rs2292334G>A) in the organic cation transporter 3 (OCT3) gene, a high-capacity transporter widely expressed in various tissues, affect susceptibility to type 2 diabetes (T2D) in patients newly diagnosed with T2D. METHODS: We performed a study with 150 newly diagnosed patients with T2D and 152 controls. The genetic analyses were performed using the restricted fragment length polymorphism (RFLP) after PCR amplification...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625318/prognostic-value-of-different-allelic-polymorphism-of-aldosterone-synthase-receptor-in-a-congestive-heart-failure-european-continental-ancestry-population
#10
Mauro Feola, Martino Monteverde, Daniela Vivenza, Marzia Testa, Laura Leto, Valentina Astesana, Francesco Mussapi, Antonello Vado, Marco Merlano, Cristiana Lo Nigro
Aldosterone synthase (CYP11B2) is as an 9-exon gene on chromosome 8q22 and exists as a common single nucleotide polymorphism C-T transition for position -344. The aim of this study was to assess the -344T/C polymorphism of the aldosterone synthase promoter in a European continental ancestry congestive heart failure (CHF) population. METHODS: Patients discharged after an acute decompensation were enrolled and underwent echocardiography, determination of BNP, evaluation of non-invasive cardiac outputs and determination of -344 T/C SNP in the aldosterone synthase gene...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625317/sphingosine-1-phosphate-postconditioning-protects-against-myocardial-ischemia-reperfusion-injury-in-rats-via-mitochondrial-signaling-and-akt-gsk3%C3%AE-phosphorylation
#11
Rui Fang, Lu-Lu Zhang, Li-Zhi Zhang, Wenchang Li, Mengmeng Li, Ke Wen
BACKGROUND AND AIMS: Although preconditioning of sphingosine 1-phosphate (S1P) has been shown to protect myocytes from hypoxia reoxgenation injury in vitro, the role of S1P postconditioning on myocardial ischemia reperfusion injury (MIRI) in vivo and its related mechanism are unknown. The aim of this study was to investigate the protective role of sphingosine 1-phosphate (S1P) postconditioning in MIRI via its effects on mitochondrial signaling and Akt/Gsk3β phosphorylation. METHODS: Rats were subjected to MIRI, consisting of 30 min of ischemia followed by 120 min of reperfusion, with S1P administered at the beginning of the reperfusion...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28625316/mesenchymal-stem-cell-based-therapy-as-a-new-horizon-for-kidney-injuries
#12
REVIEW
Amaneh Mohammadi Roushandeh, Marzie Bahadori, Mehryar Habibi Roudkenar
Today, the prevalence of kidney diseases is increasing around the world, but there has still been no effective medical treatment. The therapeutic choices are confined to supportive cares and preventive strategies. Currently, mesenchymal stem cells (MSCs)-based cell therapy was proposed for the treatment of kidney injuries. However, after the transplantation of MSCs, they are exposed to masses of cytotoxic factors involving an inflammatory cytokine storm, a nutritionally-poor hypoxic environment and oxidative stresses that finally lead to minimize the efficacy of MSCs based cell therapy...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577875/circulating-mir-150-mir-192-mir-200b-and-mir-423-3p-as-non-invasive-biomarkers-of-chronic-allograft-dysfunction
#13
Sepideh Zununi Vahed, Ahmad Poursadegh Zonouzi, Fariba Mahmoodpoor, Nasser Samadi, Mohammadreza Ardalan, Yadollah Omidi
BACKGROUND AND AIMS: Chronic allograft dysfunction (CAD) is the major cause of renal allograft loss and can only be diagnosed by invasive histological examinations. The current study aimed to determine whether or not the circulating miR-125a, miR-150, miR-192, miR-200b, miR-423-3p and miR-433 could serve as predictors of graft outcome in the renal transplant recipients with CAD. METHODS: To evaluate the expression levels of miRNAs, we used quantitative real-time PCR (qPCR) and analyzed the plasma samples of 53 renal transplant recipients, including: 27 recipients with stable graft function (SGF), 26 recipients with biopsy-proven interstitial fibrosis and tubular atrophy (IFTA) and 15 healthy controls...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577874/ras-genetic-variants-in-interaction-with-ace-inhibitors-drugs-influences-essential-hypertension-control
#14
Farzad Heidari, Ramachandran Vasudevan, Siti Zubaidah Mohd Ali, Patimah Ismail, Mohammad Arkani
BACKGROUNDS AND AIMS: Essential Hypertension (EH) is a common disorder associated with increased cardiovascular morbidity and mortality in Malaysia. To investigate how genetic polymorphisms of the renin-angiotensin-aldosterone system (RAS) influence EH control with angiotensin-converting enzyme inhibitor drugs (ACEI). METHODS: A case-control, cross-sectional population-based nested study (n = 142) included hypertensive subjects treated with ACEI drugs, either lisinopril or enalapril (20 mg, once daily) as monotherapy for 24 weeks...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577873/increased-circulating-autoantibodies-levels-of-igg-iga-igm-against-cytokeratin-18-and-cytokeratin-19-in-chronic-obstructive-pulmonary-disease
#15
Yin Xiong, Sihai Gao, Guangwei Luo, Guilian Cheng, Wei Huang, Rui Jiang, Yueqin Wang, Tianpen Cui
BACKGROUND AND AIMS: Autoimmune processes are involved in the progression of chronic obstructive pulmonary disease (COPD). Autoantibodies against cytokeratin 18 (CK18) and cytokeratin 19 (CK19) could be associated with lung injury. We undertook this study to investigate the role of these autoantibodies against CK18 and CK19 in the development of COPD. METHODS AND RESULTS: We used blood samples from 228 COPD patients or 136 healthy controls and male C57BL/6j mice as experimental subjects to analyze the serum autoantibody levels against CK18 or CK19 autoantigen by enzyme-linked immunosorbent assay (ELISA)...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577872/association-of-adiponectin-with-subclinical-atherosclerosis-in-a-mexican-mestizo-population
#16
Juan Gabriel Juárez-Rojas, Rosalinda Posadas-Sánchez, María Del Rocío Martínez-Alvarado, Margarita Torres-Tamayo, Esteban Jorge-Galarza, Erika Yamel Mancilla-Valenzuela, Carlos Posadas-Romero, Guillermo Celestino Cardoso-Saldaña, María Del Carmen González-Salazar, Gilberto Vargas-Alarcón, Aida Xochitl Medina-Urrutia
BACKGROUND AND AIMS: Adiponectin (ADPN) is a cardioprotective adipocytokine, and its association with atherosclerosis development is controversial. The aim of the present study was to assess the association of low ADPN plasma levels with the presence of subclinical atherosclerosis in a Mexican-Mestizo population without history of diabetes or coronary artery disease (CAD). METHODS: In 818 subjects (53.4 ± 9 years; 49.9% women) anthropometry, subcutaneous and visceral adipose tissue, lipids, glucose, C-reactive protein (CRP), insulin, and ADPN levels were determined...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577871/loperamide-induced-cardiac-depression-is-enhanced-by-hyperglycemia-evidence-relevant-to-loperamide-abuse
#17
Shih-Hsiang Lo, Ho-Shan Niu, Yung-Ze Cheng, Chiang-Shan Niu, Juei-Tang Cheng, Po-Ming Ku
BACKGROUND AND AIMS: Cardiac dysryhthmias and death are reported after loperamide abuse. The mechanism of death is not clear and cardiac depression may play a role in this mechanism. Loperamide is widely used as an agonist of the μ-opioid receptor (MOR) in clinical practice. In skeletal muscle, an increase in MOR in response to hyperglycemia is largely attributable to higher expression of the transducer and activator of transcription 3 (STAT3), which binds to the promoter of the MOR genes...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577870/mitochondria-as-the-target-for-the-modulatory-effect-of-curcumin-in-oxaliplatin-induced-toxicity-in-isolated-rat-liver-mitochondria
#18
Mohammad Waseem, Suhel Parvez, Heena Tabassum
BACKGROUND AND AIMS: To explore hepatoprotective action of curcumin (CMN, a bioflavonoid) on oxaliplatin (Oxa)-triggered mitochondrial oxidative stress and respiratory chain complexes in liver of rats. Oxa is a ubiquitously utilized platinum-based chemotherapeutic agent commonly used for the treatment of colorectal cancer. Mitochondria have recently emerged as targets for anticancer drugs in several kinds of toxicity including hepatotoxicity that can lead to neoplastic disease. There is a dearth of evidence involving the role of mitochondria in mediating Oxa-evoked hepatotoxicity and its underlying mechanism is still debatable...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577869/polyunsaturated-fatty-acids-differentially-modulate-cell-proliferation-and-endocannabinoid-system-in-two-human-cancer-lines
#19
Repossi Gastón, Pasqualini María Eugenia, Undurti N Das, Aldo R Eynard
BACKGROUND AND AIMS: Evidence suggests that quantity and quality of dietary polyunsaturated fatty acids (PUFAs) play a role in the development of cancer. However, the mechanisms involved in this interaction(s) are not clear. Endocannabinoids are lipid metabolites known to have growth modulatory actions. We studied the effect of supplementation with PUFAs ω-6 and ω-3 (essential fatty acids, EFAs), saturated and monounsaturated fatty acids (non-EFAs) on the growth of tumor cells and modifications in their endocannabinoid content...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28577868/prenatal-food-restriction-with-postweaning-high-fat-diet-alters-glucose-metabolic-function-in-adult-rat-offspring
#20
Di Xiao, Hao Kou, Li Zhang, Yu Guo, Hui Wang
BACKGROUND AND AIMS: The present study was designed to investigate the effects of prenatal food restriction (PFR) with postweaning high-fat diet (HFD) on glucose metabolic function in adult offspring. METHODS: Pregnant Wistar rats were given PFR treatment from gestational day 11 to spontaneous delivery. All pups were fed by HFD after weaning. Oral glucose tolerance test (OGTT) was conducted at postnatal week (PW) 20. Rats were decapitated in PW24 to collect liver and pancreas, and expression of hepatic insulin signaling genes were then quantified...
January 2017: Archives of Medical Research
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