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Archives of Medical Research

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https://www.readbyqxmd.com/read/29779755/resistive-part-of-impedance-as-a-possible-indicator-of-hepatocellular-carcinoma
#1
Jeny Salazar-Anguiano, María de Guadalupe Chávez-López, Violeta Zúñiga-García, Javier Camacho, David Elías-Viñas
BACKGROUND AND AIMS: In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical impedance measure technique, and thus potentially improving liver cancer diagnosis. METHODS: Hepatocellular carcinoma (HCC) was induced in male Wistar rats by the administration of diethylnitrosamine (DEN) during 16 weeks...
May 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29754746/rs3212227-snp-in-the-il12b-gene-prevents-delayed-graft-function-after-kidney-transplantation
#2
Vladimir Perovic, Milos Markovic, Milica Kravljaca, Emina Milosevic, Milica Djoric, Vera Pravica, Radomir Naumovic
BACKGROUND AND AIMS: Transplantation is the best treatment option for end stage kidney disease. The most common early complications in post-transplant period are acute rejection (AR) of the graft and delayed graft function (DGF). The underlying mechanisms in these events are heterogeneous and at least in part involve cytokine genes which regulate immune response to allograft. We have investigated whether functional single nucleotide polymorphisms (SNP) in the genes encoding IFN-γ (IFNG), TNF (TNFA), IL-10 (IL10) and p40 subunit of IL-12/IL-23 (IL12B) could predict risk of AR and DGF in kidney allograft recipients...
May 10, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29716743/foxo3a-reverses-the-cisplatin-resistance-in-ovarian-cancer
#3
Mudan Lu, Xuan Chen, Jianping Xiao, Jingying Xiang, Lan Yang, Daozhen Chen
OBJECTIVE: Ovarian cancer is one of the most serious disease in female reproductive system. Platinum is the first-line drug for the treatment of ovarian cancer, while the resistance of platinum drug in clinical hindered the relief ovarian cancer. Our previous study found that decreased FOXO3a might be a poor prognosis in human ovarian cancer. In this research, we study whether FOXO3a was involved in the mechanism of platinum drug resistance. METHODS: The CCK-8 and FACS analysis were used to monitor the survival of ovarian cancer, and the FOXO3a expression was detected by western-blot...
April 28, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29705673/ace-apoa5-and-mtp-gene-polymorphisms-analysis-in-relation-to-triglyceride-and-insulin-levels-in-pediatric-patients
#4
Lilia Carranza-González, Rafael B R León-Cachón, María Antonia González-Zavala, Clara Ríos-Ibarra, Jesús Morlett-Chávez, Celia Sánchez-Domínguez, Ana Cepeda-Nieto, Mauricio Salinas-Santander
BACKGROUND AND AIMS: Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation...
April 25, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29703609/persistent-arthralgia-and-related-risks-factors-a-cohort-study-at-12-months-from-laboratory-confirmed-chikungunya-infection
#5
Efrén Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, José Guzmán-Esquivel, Enrique Higareda-Almaraz, Martha Alicia Higareda-Almaraz, Ramón Alberto Sánchez-Piña, Agustin Lugo-Radillo
AIM OF THE STUDY: To assess the cumulative incidence and clinical markers associated with persistent arthralgia (PA) at 12 months from acute chikungunya virus (CHIKV) infection. METHODS: A multicenter retrospective cohort study was conducted in the state of Colima, Mexico, and 217 serologically confirmed cases of CHIKV infection were enrolled. Participants aged 15 years and older were interviewed on 6 months basis from acute illness onset and the main binary outcome was self-reported PA at 12 months...
April 24, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29703608/influence-of-snps-in-genes-that-modulate-lung-disease-severity-in-a-group-of-mexican-patients-with-cystic-fibrosis
#6
Emiy Yokoyama, Margarita Chávez-Saldaña, Lorena Orozco, Francisco Cuevas, José Luis Lezana, Rosa María Vigueras-Villaseñor, Julio Cesar Rojas-Castañeda, Daniel Adrian Landero
BACKGROUND: The variation in cystic fibrosis (CF) lung disease not always is explained by the CFTR genotype, so it has become apparent that modifier genes must play a considerable role in the phenotypic heterogeneity of CF, so we investigated the association of allelic variants in modifier genes that modulate the severity of lung function in a group of Mexican patients diagnosed with CF. METHODS: We included 140 CF patients classified according to lung phenotype and analyzed 17 single nucleotide polymorphisms (SNPs) by TaqMan® allelic discrimination...
April 24, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29699810/characterization-of-folic-acid-surface-coated-selenium-nanoparticles-and-corresponding-in-vitro-and-in-vivo-effects-against-breast-cancer
#7
Ahmad Reza Shahverdi, Faranak Shahverdi, Elnaz Faghfuri, Mohammad Reza Khoshayand, Faranak Mavandadnejad, Mohammad Hossein Yazdi, Mohsen Amini
BACKGROUNDS AND AIMS: Selenium nanoparticles (SeNPs) have been reported to exhibit an inhibitory effect on cancer cells. In the present study, we aimed to compare the in vitro and in vivo effects of SeNPs and folic acid surface-coated selenium nanoparticles (FA@SeNPs) on breast cancer. METHODS: FA@SeNPs and SeNPs were chemically synthesized and characterized with different instrumental techniques. The cytotoxicity of both nanomaterials was evaluated against 4T1 cells...
April 23, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29699809/serum-paraoxonase-1-concentration-as-a-potential-predictor-of-urinary-bladder-cancer-recurrence-a-five-year-follow-up-study
#8
Simona Iftimie, Anabel García-Heredia, Francesc Pujol-Bosch, Antoni Pont-Salvadó, Ana Felisa López-Azcona, Anna Hernández-Aguilera, Noemí Cabré, Fedra Luciano-Mateo, Isabel Fort-Gallifa, Antoni Castro, Jordi Camps, Jorge Joven
This study provides preliminary information on the usefulness of measuring serum paraoxonase-1 (PON1) concentration and activity (and other inflammatory markers) to predict tumor recurrence in patients with urinary bladder cancer. We studied a total of 39 hospitalized patients in whom the diagnosis of urinary bladder cancer was confirmed by transurethral resection. After five years of follow-up, 29 patients presented with tumor recurrence. As control subjects, we also studied 61 healthy subjects and a further 132 hospitalized patients who had a urinary catheter-related infection due to causes other than cancer...
April 23, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29699808/vitamin-a-and-retinoic-acid-exhibit-protective-effects-on-necrotizing-enterocolitis-by-regulating-intestinal-flora-and-enhancing-the-intestinal-epithelial-barrier
#9
Sa Xiao, Qiuping Li, Kun Hu, Yu He, Qing Ai, Liuhong Hu, Jialin Yu
BACKGROUND: Exaggerated inflammation that characterizes necrotizing enterocolitis (NEC) is caused by the invasion of pathogens through an immature intestinal barrier. Vitamin A (VA) and retinoic acid (RA) play important roles in the growth of epithelial tissue and in modulating immune function. OBJECTIVE: To investigate the roles of VA and RA in the development of NEC. METHODS: Levels of serum retinol in patients and in a NEC mouse model were detected with high-performance liquid chromatography...
April 23, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29681412/volatolome-of-the-female-genitourinary-area-toward-the-metabolome-of-cervical-cancer
#10
Miriam Rodríguez-Esquivel, Juan Rosales, Rafael Castro, Teresa Apresa-García, Ónix Garay, Pablo Romero-Morelos, Daniel Marrero-Rodríguez, Keiko Taniguchi-Ponciano, Ricardo López-Romero, Héctor Guerrero-Flores, Betsabé Morales, Mónica Mendoza-Rodríguez, Dejanira Mosso-Lara, Itzalia Núñez-Nolasco, Paola Castro-Alba, Sergio E Meza-Toledo, Mauricio Salcedo
BACKGROUND AND AIMS: Different Volatile Organic Compounds (VOCs) obtained from several human fluids (volatolome) has been reported as potential biomarkers for a great variety of diseases including cancer. At present, volatolomic profile data of the female genital area is scarce. METHODS: To identify the VOCs related to the female genitourinary area of healthy and Cervical Cancer (CC)-affected women used a pad, as a non-invasive tool for sample gathering was necessary...
April 19, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29680307/prognostic-value-of-cd95-active-caspase-3-and-bcl-2-expression-in-adult-patients-with-de-novo-acute-lymphoblastic-leukemia
#11
Laura Arcelia Montiel-Cervantes, Elba Reyes-Maldonado, Jaime Garcia-Chavez, Alvaro Hernandez-Caballero, Rubiraida Molina-Aguilar, Miriam America Garcia-Ruiz Esparza, Jorge Vela-Ojeda
BACKGROUND: Acute lymphoblastic leukemia is an aggressive malignant disease with high mortality rates in adults. AIM OF THE STUDY: The expression levels of CD95, active caspase-3, and Bcl-2 were determined in 111 patients with de novo acute lymphoblastic leukemia (ALL) and correlated with overall survival (OS) and disease-free survival (DFS). METHODS: The immunophenotyped ok leukemia and the expression of CD95, active caspase-3, and Bcl-2, were determined by flow cytometry...
April 18, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29680306/10-years-analysis-of-diabetes-related-major-lower-extremity-amputations-in-mexico
#12
Iván de Jesús Ascencio-Montiel
BACKGROUND: Little is known about diabetes-related major lower extremity amputations (DMLEA) burden in México. AIM OF THE STUDY: To describe DMLEA hospitalization rates, in-hospital survival rates, characteristics associated with all-cause in-hospital mortality and direct costs of hospitalization during the 2005-2015 period, in the two principal Health Institutions in Mexico: the Mexican Institute of Social Security (IMSS) and the Ministry of Health (MoH). METHODS: A secondary data analysis was conducted using hospital discharge information obtained from administrative databases...
April 18, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29678352/differential-impact-of-sleep-duration-on-fasting-plasma-glucose-level-according-to-work-timing
#13
Chan-Hee Jung, Sang Hee Jung, Bora Lee, Dukhyun Choi, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
BACKGROUND AND AIM: To quantify the differential contribution of sleep duration on fasting plasma glucose level by traditional regular daytime work and shift work in subjects without diabetes. METHODS: Self-reported sleep duration and work type and timing were determined in a cross-sectional sample of 9123 participants aged 20-65 years from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2015. Those who responded that they worked between 6 am and 6 pm were classified as "traditional regular daytime workers; "those who worked in the afternoon, at night, or in several types of shift work were classified as "shift workers...
April 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29678351/clinical-and-inflammatory-phenotyping-can-electronic-nose-and-nmr-based-metabolomics-work-at-the-bedside
#14
Mauro Maniscalco, Andrea Motta
Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing...
April 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29665969/copeptin-plasma-levels-are-associated-with-decline-of-renal-function-in-patients-with-type-2-diabetes-mellitus
#15
Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel Gómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar
BACKGROUND: Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. OBJECTIVE: Evaluate whether plasma copeptin levels may be used as a biomarker of decline renal function in patients with T2DM. RESEARCH DESIGN AND METHODS: A total of 480 patients with T2DM and different stages of CKD were included...
April 14, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29555303/intranasal-administration-of-a-naked-plasmid-reached-brain-cells-and-expressed-green-fluorescent-protein-a-candidate-for-future-gene-therapy-studies
#16
Norma Oviedo, Leticia Manuel-Apolinar, Sandra Orozco-Suárez, Teresa Juárez-Cedillo, Vilma Carolina Bekker Méndez, Emiliano Tesoro-Cruz
BACKGROUND: Intranasal administration (Int adm) has been well-studied and offers the possibility to deliver larger molecular weight biologics, such as proteins, viral vectors, nanoparticles, and naked plasmids to the brain and treat a variety of diseases in the central nervous system. The predominant challenge in this field is finding efficient vectors that are capable of crossing the blood-brain barrier (BBB). OBJECTIVES: Here, we investigated whether a naked plasmid (pIRES-hrGFP-1a), could cross the BBB, reach brain cells and express green fluorescent protein (GFP) after int-adm and propose it as candidate for future gene therapy studies...
March 16, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29292011/gut-microbiota-in-obesity-and-metabolic-abnormalities-a-matter-of-composition-or-functionality
#17
REVIEW
Sofia Moran-Ramos, Blanca E López-Contreras, Samuel Canizales-Quinteros
The obesity pandemic and the metabolic complications derived from it represent a major public health challenge worldwide. Although obesity is a multifactorial disease, research from the past decade suggests that the gut microbiota interacts with host genetics and diet, as well as with other environmental factors, and thus contributes to the development of obesity and related complications. Despite abundant research on animal models, substantial evidence from humans has only started to accumulate over the past few years...
December 29, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29290328/human-intestinal-microbiota-interaction-between-parasites-and-the-host-immune-response
#18
REVIEW
Oswaldo Partida-Rodríguez, Angélica Serrano-Vázquez, Miriam E Nieves-Ramírez, Patricia Moran, Liliana Rojas, Tobias Portillo, Enrique González, Eric Hernández, B Brett Finlay, Cecilia Ximenez
The human gut is a highly complex ecosystem with an extensive microbial community, and the influence of the intestinal microbiota reaches the entire host organism. For example, the microbiome regulates fat storage, stimulates or renews epithelial cells, and influences the development and maturation of the brain and the immune system. Intestinal microbes can protect against infection by pathogenic bacteria, viruses, fungi and parasites. Hence, the maintenance of homeostasis between the gut microbiota and the rest of the body is crucial for health, with dysbiosis affecting disease...
December 28, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29229199/microbiota-and-aging-a-review-and-commentary
#19
REVIEW
Carmen García-Peña, Teresa Álvarez-Cisneros, Ricardo Quiroz-Baez, Robert P Friedland
Although there is a consensus that the dominant species that make up the adult microbiota remains unchanged in elderly people, it has been reported that there are significant alterations in the proportion and composition of the different taxa, leading to reduced microbiota diversity, as well as an increase of enteropathogens that may lead to chronic inflammation. The ageing of mucosal immune and motor systems also contributes to these changes. As the individual ages, there is a loss in the number of Peyer's patches, an altered local capacity of T and B cell functions as well as chronic macrophage activation...
December 8, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29224909/hygiene-hypothesis-in-asthma-development-is-hygiene-to-blame
#20
REVIEW
Erik van Tilburg Bernardes, Marie-Claire Arrieta
Industrialized countries have registered epidemic rates on allergic diseases, such as hay fever, asthma, eczema, and food allergies. The Hygiene Hypothesis was born from work made by Dr. David Strachan, who observed that younger siblings were less susceptible to eczema and asthma, and proposed that this was a result of increased transmission of infectious agents via unhygienic practices within a household. This initial hypothesis was then reframed as the old friends/microbiota hypothesis, implicating non-pathogenic commensal microorganisms as the source of immunomodulatory signals necessary to prevent immune-mediated chronic disorders...
December 7, 2017: Archives of Medical Research
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