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Archives of Medical Research

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https://www.readbyqxmd.com/read/30213474/apolipoprotein-e-in-cardiovascular-diseases-novel-aspects-of-an-old-fashioned-enigma
#1
REVIEW
Elisa A Liehn, Victor Ponomariov, Rodica Diaconu, Ioana Streata, Mihai Ioana, Gustavo E Crespo-Avilan, Sauri Hernández-Reséndiz, Hector A Cabrera-Fuentes
The presence of different APOE isoforms represents a well-known risk factor for cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart and neurological diseases, this review summarizes the less-known functions of APOE and the possible implications for cardiovascular disorders. Beyond the role as lipid transporting protein, its involvement in lipid membrane homeostasis and signaling, as well as its nuclear transcriptional effects suggests a more complex role of APOE, receiving great interest from researchers and physicians from all medical fields...
September 10, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30195701/vaccination-status-and-other-preventive-measures-in-medical-school-big-needs-and-opportunities
#2
Diana Vilar-Compte, Daniel de-la-Rosa-Martinez, Samuel Ponce de León
BACKGROUND: Proper immunization and knowledge in infection prevention are key factors in protecting medical students. AIM OF THE STUDY: To describe the status on vaccination recommended for healthcare workers (HCW) and infection prevention knowledge. METHODS: We conducted a cross-sectional study on medical students at clinical years of medical school from a public University in Mexico. RESULTS: A total of 1,824 medical students responded the survey...
September 5, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30017234/effect-of-endoplasmic-reticulum-stress-and-autophagy-in-the-regulation-of-post-infarct-cardiac-repair
#3
Rongjie Lin, Zizhuo Su, Xiaohui Tan, Yinqing Su, Yuyang Chen, Xiaorong Shu, Shumin Liang, Jingfeng Wang, Shuanglun Xie
BACKGROUND: Acute myocardial infarction (AMI) is reported to be accompanied by endoplasmic reticulum (ER) stress and autophagy induction. Nevertheless, the roles of ER stress and autophagy in post-infarct reparative fibrosis remain to be elucidated. AIM: To investigate the effects of ER stress and autophagy on the regulation of post-infarct reparative fibrosis. METHODS: The expression of GRP78 and LC3 in cardiac fibroblasts in human heart tissues obtained from patients with or without AMI was assessed by immunofluorescence...
July 12, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30119981/data-mining-and-endocrine-diseases-a-new-way-to-classify
#4
Juan Salazar, Cristobal Espinoza, Andres Mindiola, Valmore Bermudez
Data mining consists of using large database analysis to detect patterns, relationships and models in order to describe (or even predict) the appearance of a future event; to accomplish this, it uses classification methods, rules of association, regression patterns, link and cluster analyses. Recently this approach has been used to propose a new diabetes mellitus classification, using information analysis techniques through which the selection bias minimally influences categorization, this new focus that includes data mining previously implemented to predict, identify biomarkers, complications, therapies, health policies, genetic and environmental effects of this disease; it could be generalized in the field of endocrinology, in the classification of other endocrine diseases...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30119980/role-of-response-to-diuretic-in-predicting-prognosis-in-discharged-heart-failure-patients-after-an-acute-decompensation
#5
Mauro Feola, Marzia Testa, Cinzia Ferreri, Marco Cardone, Mario Sola, Sara Ariotti, Gian Luca Rosso
BACKGROUND: The diuretic response has been shown to be a robust independent marker of cardiovascular outcomes in acute heart failure (ADHF) patients. The objectives of this clinical research, will aim are to: a) include diuresis in the formula for diuretic response (R-to-D); b) add to R-to-D the value of a pre-discharged determination of galectin-3 and BNP in predicting mid-term clinical outcome. METHODS: Consecutive patients discharged alive after an ADHF were enrolled...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30119979/endothelial-colony-forming-cells-attenuate-ventilator-induced-lung-injury-in-rats-with-acute-respiratory-distress-syndrome
#6
Ying-Nan Ju, Jing Gong, Xue-Ting Wang, Jing-Li Zhu, Wei Gao
BACKGROUND: Mechanical ventilation (MV) can cause ventilator-induced lung injury (VILI). AIM OF THE STUDY: This study investigated whether endothelial colony-forming cells (ECFC) could inhibit VILI in a rat model of acute respiratory distress syndrome (ARDS). METHODS: Male Wistar rats received the femoral artery and venous cannulation (sham group) or were injected intravenously with 500 μg/kg lipopolysaccharide to induce ARDS. The ARDS rats were subjected to MV...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30119978/cardiometabolic-risk-indicators-for-kidney-disease-in-mexican-patients-with-type-2-diabetes
#7
Lubia Velázquez-López, Rubí Hernández-Sánchez, Ivonne Roy-García, Abril Violeta Muñoz-Torres, Patricia Medina-Bravo, Jorge Escobedo-de la Peña
INTRODUCTION: Kidney disease is one of the main complications in the diabetic patient. Risk factors such as obesity, dyslipidemia, and hyperglycemia have been associated with increased urinary albumin excretion (UAE) and decreased glomerular filtration rates (GFR). However, the data are inconsistent. The objective of this study was to identify the primary risk factors associated with kidney disease in Mexican patients with type 2 diabetes. METHODS: A cross-sectional study was done in 395 patients with type 2 diabetes from four primary-care clinics...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30119977/impact-of-mir-302b-on-calcium-phosphorus-metabolism-and-vascular-calcification-of-rats-with-chronic-renal-failure-by-regulating-bmp-2-runx2-osterix-signaling-pathway
#8
Wen-Li Sun, Nan Wang, Yan Xu
OBJECTIVE: To investigate how miR-302b affect the calcium-phosphorus metabolism and vascular calcification (VC) of rats with chronic renal failure (CRF) via the regulation of bone morphogentic proteins 2/Runt-related transcription factor 3/Osterix (BMP-2/Runx2/Osterix) signaling pathway. METHODS: SD rats were selected to establish CRF rat models and assigned into Sham, CRF, CRF + miR-302b, and CRF + miR-NC groups. The biochemical indexes of rats were detected at 8th and 12th week...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30119976/selective-screening-of-fatty-acids-oxidation-defects-and-organic-acidemias-by-liquid-chromatography-tandem-mass-spectrometry-acylcarnitine-analysis-in-brazilian-patients
#9
Carmen Regla Vargas, Graziela Schmitt Ribas, Janine Machado da Silva, Angela Sitta, Marion Deon, Daniella de Moura Coelho, Moacir Wajner
BACKGROUND: Inborn errors of metabolism (IEM) are diseases which can lead to accumulation of toxic metabolites in the organism. AIM OF THE STUDY: To investigate, by selective screening, mitochondrial fatty acid oxidation defects (FAOD) and organic acidemias in Brazilian individuals with clinical suspicion of IEM. METHODS: A total of 7,268 individuals, from different regions of Brazil, had whole blood samples impregnated on filter paper which were submitted to the acylcarnitines analysis by liquid chromatography/tandem mass spectrometry (LC/MS/MS) at the Medical Genetics Service of Hospital de Clínicas de Porto Alegre, Brazil, during July 2008-July 2016...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30104075/insulin-sensitizers-modulate-gnrh-receptor-expression-in-pcos-rats
#10
Roshni Patel, Gaurang Shah
BACKGROUND: Insulin sensitizers like metformin and pioglitazone are clinically used since last decades for the treatment of PCOS, but their efficacy and possible role in PCOS patients remains questionable. Also, the mechanism by which these insulin sensitizers show effect is not clear. AIM OF THE STUDY: To evaluate the effect of metformin and pioglitazone on leutinizing hormone and follicle stimulating hormone receptor mRNA expression, hyperandrogenism and insulin resistance in high fat diet induced and letrozole induced PCOS in rats...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30037543/improvement-in-the-diagnosis-of-tuberculosis-combining-mycobacterium-tuberculosis-immunodominant-peptides-and-serum-host-biomarkers
#11
Juan E López-Ramos, Noe Macías-Segura, Betzaida Cuevas-Cordoba, Zaida Araujo-Garcia, Yadira Bastián, Julio E Castañeda-Delgado, Edgar E Lara-Ramirez, Benjamin Gándara-Jasso, Carmen J Serrano, Eva Salinas, Jose A Enciso-Moreno
BACKGROUND: Pulmonary tuberculosis (PTB) is a public health problem with 10.4 million new cases reported in 2017 (1). According to the World Health Organization (WHO), accurate diagnostic tests based in serum biomarkers to detect new cases of tuberculosis are necessary. AIM OF THE STUDY: To evaluate antibodies against Mycobacterium. tuberculosis (Mtb) peptides (Ab-Mtb) and three soluble host biomarkers by ELISA serial multiple test in sera from non-infected controls (NIC, n = 31), latent tuberculosis (LTB, n = 37) and PTB (n = 28) patients in a diagnosis tuberculosis assay...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30031631/serum-amyloid-a-paraoxonase-1-activity-and-apolipoprotein-concentrations-as-biomarkers-of-subclinical-atherosclerosis-risk-in-adrenal-incidentaloma-patients
#12
Narin Nasiroglu Imga, Canan Topcuoglu, Dilek Berker, Turan Turhan
BACKGROUND: Adrenal incidentalomas (AIs), particularly subclinical hypercortisolism (SH), are related to an increased risk of atherosclerosis. The anti-oxidative enzyme paraoxonase-1 (PON1) and the acute phase reactant serum amyloid A (SAA) are transported by highdensity lipoprotein and reciprocally regulated in acute inflammatory response. Our aim was to investigate serum SAA, PON1, and apolipoprotein levels as indicators of subclinical atherosclerosis in patients with nonfunctioning AI (NFAI) and SH...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/30017233/human-catsper1-promoter-is-regulated-by-creb1-and-crem%C3%AF-transcriptional-factors-in-vitro
#13
Norma Oviedo, Lizdy Ortiz-Borrayo, Javier Hernández-Sánchez, Salma Elizabeth Jiménez-Badillo, Emiliano Tesoro-Cruz, Esperanza Moreno-Navor, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Méndez
BACKGROUND: The CATSPER1 gene encodes a CATSPER channel protein that selectively permeates Ca2+ ions, and CATSPER expression in sperm is essential for flagellum hyperactivation and, thus, male fertility. Little is known regarding the transcriptional regulation of CATSPER1, but previous studies have performed in silico analyses of transcription factor binding sites, including three CRE sites designated 0-2, in which CRE0 is located near the transcription start site. OBJETIVES: We investigate if overexpression of CREB-A and CREMτ transcription factors might regulate CATSPER1 expression...
April 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29961608/mannose-binding-lectin-and-pentraxin-3-in-patients-with-diabetic-retinopathy
#14
Kenzo Hokazono, Fernando Sakata Belizário, Vanessa Portugal, Iara Messias-Reason, Renato Nisihara
BACKGROUND: Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR). AIM OF THE STUDY: To evaluate whether plasma MBL and PTX3 levels are associated with the development of DR and if patients with and without DR can be distinguished. METHODS: The patients were divided into three groups: diabetic without DR; with mild/moderate DR, and with severe/proliferative DR...
February 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29960828/health-systems-in-latin-america-the-search-for-universal-health-coverage
#15
REVIEW
Julio Frenk, Octavio Gómez-Dantés
This paper discusses the health challenges faced by countries in Latin America. These challenges have two dimensions: those related to the health needs of populations and those related to the way in which health systems are responding to these needs. The main conclusion is that in order to improve health conditions and move towards universal health coverage, Latin American countries need to design a new generation of policy innovations based on the separation of the three main functions of health systems: financing, delivery and stewardship...
February 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29907426/maternal-obesity-as-a-risk-factor-for-the-development-of-total-anomalous-pulmonary-venous-connection-in-their-offspring
#16
Evelyn G Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Klünder-Klünder, Begoña Segura-Stanford, Julio R Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T Granados Riverón, Leonardo J Mejía-Marín, Norma A Balderrabano-Saucedo, Alejandra Contreras-Ramos, Guadalupe Díaz-Rosas, Rocío Sánchez-Urbina
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. METHODS: 55 mother-child binomials with isolated TAPVC (group I) and 152 healthy mother-child binomials (group II) were included...
February 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29861329/pathway-to-tau-modifications-and-the-origins-of-alzheimer-s-disease
#17
Ricardo B Maccioni, José Pablo Tapia, Leonardo Guzman-Martinez
No abstract text is available yet for this article.
February 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29803546/seasonal-variations-in-cerebral-palsy-births
#18
Dorota Sienkiewicz, Grażyna Paszko-Patej, Bożena Okurowska-Zawada, Wojciech Kułak
INTRODUCTION: Previous studies of cerebral palsy (CP) suggest that it seasonal variations in the incidence of CP. The purpose of this paper was to compare seasonal variations in the incidence of cerebral palsy (CP) in Podlaskie Province, Poland, between 1990-1999 (study 2005) and 2000-2014 (study 2017) in a retrospective case-controlled study. MATERIALS AND METHODS: Data were obtained from the hospital database. We compared CP births between January 1, 1990, and December 31, 1999, n = 212 (116 boys, 96 girls) and January 1, 2000, and December 31, 2014, n = 205 (114 boys, 91 girls)...
February 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29779755/resistive-part-of-impedance-as-a-possible-indicator-of-hepatocellular-carcinoma
#19
Jeny Salazar-Anguiano, María de Guadalupe Chávez-López, Violeta Zúñiga-García, Javier Camacho, David Elías-Viñas
BACKGROUND AND AIMS: In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical impedance measure technique, and thus potentially improving liver cancer diagnosis. METHODS: Hepatocellular carcinoma (HCC) was induced in male Wistar rats by the administration of diethylnitrosamine (DEN) during 16 weeks...
February 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29754746/cytokine-gene-polymorphism-profiles-in-kidney-transplant-patients-association-of-1188a-c-rs3212227-snp-in-the-il12b-gene-prevents-delayed-graft-function
#20
Vladimir Perovic, Milos Markovic, Milica Kravljaca, Emina Milosevic, Milica Djoric, Vera Pravica, Radomir Naumovic
BACKGROUND AND AIMS: Transplantation is the best treatment option for end stage kidney disease. The most common early complications in post-transplant period are acute rejection (AR) of the graft and delayed graft function (DGF). The underlying mechanisms in these events are heterogeneous and at least in part involve cytokine genes which regulate immune response to allograft. We have investigated whether functional single nucleotide polymorphisms (SNP) in the genes encoding IFN-γ (IFNG), TNF (TNFA), IL-10 (IL10) and p40 subunit of IL-12/IL-23 (IL12B) could predict risk of AR and DGF in kidney allograft recipients...
February 2018: Archives of Medical Research
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