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Journal of Drug Targeting

Sweet Naskar, Ketousetuo Koutsu, Suraj Sharma
Chitosan (CS) is one of the most functional natural biopolymer widely used in the pharmaceutical field due to its biocompatibility and biodegradability. These privileges lead to its application in the synthesis of NPs for the drug during the last two decades. This article gives rise to a general review of the different chitosan nanoparticles (CSNPs) preparation techniques: Ionic gelation, emulsion cross-linking, spray-drying, emulsion-droplet coalescence method, nanoprecipitation, reverse micellar method, desolvation method, modified ionic gelation with radial polymerization and emulsion solvent diffusion, from the point of view of the methodological and mechanistic aspects involved...
August 14, 2018: Journal of Drug Targeting
Feng Yu, Sajid Asghar, Mei Zhang, Jingwei Zhang, Qineng Ping, Yanyu Xiao
Glioma is one of the most common type of malignant tumors with high morbidity and mortality rates. Due to the particular features of brain, such as blood-brain barrier or blood-tumor barrier, therapeutic agents are ineffective by systemic administration. The tumor inevitably recurs and devitalizes patients. Herein, an overview of the localized gliomas treatment strategies is provided, including direct intratumoral/intracerebral injection, convection-enhanced delivery, and the implant of biodegradable polymer systems...
August 12, 2018: Journal of Drug Targeting
Bruno Roque Lima, Caroline Correa de Tulio Augusto Roque, Maria Dirlei Begnami, Patricia Peresi, Eduardo Nobrega Pereira Lima, Celso Abdon Lopes de Mello, Felipe José Fernandez Coimbra, Rubens Chojniak, Tiago Goss Santos
Liver metastasis is the major cause of death for patients with colorectal cancer. Despite treatment with surgery and chemotherapy, patient outcomes are quite unfavorable. Thus, there is an urgent need to develop new treatment strategies with the associated establishment of good animal models. Metastatic disease can be modeled using patient-derived orthotopic xenografts, which accurately replicate intra-tumoral heterogeneity, so that various chemotherapeutic agents can be tested on individual tumors to aid in clinical decision-making...
August 8, 2018: Journal of Drug Targeting
Hui Du, Ying Chen
In the past several years, competing endogenous RNAs (ceRNAs) have emerged as a potential class of post-transcriptional regulators that alter gene expression through a microRNA-mediated mechanism. An increasing number of studies have found that ceRNAs play important roles in tumorigenesis. Cervical cancer is one of the most common cancers in female malignancies. Despite advances in our understanding of this neoplasm, patients with advanced cervical cancer still have poor prognosis. There is an urgent need to provide new insight of mechanism of cervical cancer development and may be acted as new anticancer therapeutic strategies...
July 27, 2018: Journal of Drug Targeting
Chia-Wei Lin, Ming-Shiou Jan, Jung-Hua Steven Kuo
Intercellular communication is known to be involved in various stages of tumour development and metastasis through the secretion of extracellular vesicles (EVs) containing messengers such as microRNAs (miRNAs). Therefore, this study explored miRNA profiles in cancer cell-derived EVs after non-viral gene delivery in order to better understand the molecular information of intercellular communication in cancer cells after gene delivery. Two commonly used non-viral vectors (Lipofectamine 2000 and jet polyethylenimine) were used for the delivery of gene fluorescent protein plasmid in HeLa cancer cells...
July 24, 2018: Journal of Drug Targeting
Jing-Jing Chen, Yu-Hang Gong, Ling He
G-protein coupled receptor 40 (GPR40) is also known as free fatty acid receptor 1. It is a typical 7 transmembrane receptor and currently the natural receptor of the saturated or unsaturated long-chain fatty acids. It could trigger the intracellular signalling pathway when combined with the free long-chain fatty acids, thereby controlling cells physiological function. In this review, we summarised the relationships and the potential mechanisms between the promising target GPR40, and pathogenesis and treatment of Alzheimer's disease and type 2 diabetic dementia...
July 24, 2018: Journal of Drug Targeting
Yoshiyuki Hattori, Mari Nakamura, Nozomi Takeuchi, Kyoko Tamaki, Satono Shimizu, Yuki Yoshiike, Masamitsu Taguchi, Hiroaki Ohno, Kei-Ichi Ozaki, Hiraku Onishi
Cationic liposomes composed of dialkyl cationic lipid such as 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) can efficiently deliver siRNA to the lungs following the intravenous injection of cationic liposome/siRNA complexes (lipoplexes). In this study, we examined the effect of cationic lipid of cationic liposomes on siRNA delivery to the lungs after intravenous injection. We used 6 kinds of cationic cholesterol derivatives and 11 kinds of dialkyl or trialkyl cationic lipids as cationic lipids, and prepared 17 kinds of cationic liposomes composed of a cationic lipid and 1,2-dioleoyl-L-α-glycero-3-phosphatidylethanolamine (DOPE) for evaluation of siRNA biodistribution and in vivo gene silencing effects...
July 19, 2018: Journal of Drug Targeting
Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Arun S Singh, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Michiaki Unno, Shree Ram Singh, Fritz C Eilber, Robert M Hoffman
Undifferentiated/unclassified soft tissue sarcoma (USTS) is a recalcitrant disease, therefore, precise individualized therapy is needed. Toward this goal, we previously established patient-derived orthotopic xenograft (PDOX) models of USTS in nude mice. Here, we determined the extent of uniqueness of drug response in a panel on USTS PDOX models from 5 different patients. We previously showed that 3 of the 5 patients were resistant to DOX despite DOX being first-line therapy. Two weeks after orthotopic tumor implantation, PDOX mouse models were randomized into five groups: untreated control, doxorubicin (DOX), gemcitabine/docetaxel (GEM/DOC), pazopanib (PAZ); temozolomide (TEM) and 3 PDOX cases completely resistant to DOX...
July 19, 2018: Journal of Drug Targeting
Shiming He, Zhongcheng Liu, Donggang Xu
Oral delivery is the most common method of drug administration with high safety and good compliance for patients. However, delivering therapeutic proteins to the target site via oral route involves tremendous challenge due to unfavourable conditions like biochemical barrier, mucus barrier and epithelial barriers. According to the functional differences of various protein drug delivery systems, the recent advances in pH responsive polymer-based drug delivery system, mucoadhesive polymer-based drug delivery system, absorption enhancers-based drug delivery system and composite polymer-based delivery system all were briefly summarised in this review, which not only clarified the clinic potential of these novel drug delivery systems, but also described the way for increasing oral bioavailability of therapeutic protein...
July 17, 2018: Journal of Drug Targeting
Amir Barzegar Behrooz, Amir Syahir, Syahida Ahmad
CD133 (prominin-1), a pentaspan membrane glycoprotein, is one of the most well-characterized biomarkers used for the isolation of cancer stem cells (CSCs). The presence of CSCs is one of the main causes of tumour reversal and resilience. Accumulating evidence has shown that CD133 might be responsible for CSCs tumourigenesis, metastasis and chemoresistance. It is now understood that CD133 interacts with the Wnt/β-catenin and PI3K-Akt signalling pathways. Moreover, CD133 can upregulate the expression of the FLICE-like inhibitory protein (FLIP) in CD133-positive cells, inhibiting apoptosis...
July 17, 2018: Journal of Drug Targeting
Daniel Cristian Ferreira Soares, Caroline Mari Ramos Oda, Liziane Oliveira Fonseca Monteiro, Andre Luis Branco de Barros, Marli Luiza Tebaldi
Protein-polymer conjugates have achieved tremendous attention in the last few years, since their importance in diverse fields including drug delivery, biotechnology, and nanotechnology. Over the past few years, numerous chemical strategies have been developed to conjugate different synthetic polymers onto proteins and great progress has been made. Currently, there are a handful of therapeutic polymer conjugates that have been approved by the FDA, while many hundreds of products are under extensive clinical trials and preclinical development phases...
July 16, 2018: Journal of Drug Targeting
Gaoxing Su, Dandan Miao, Yanyan Yu, Min Zhou, Peifu Jiao, Xiaolong Cao, Bing Yan, Hongyan Zhu
Combined chemo-photothermal therapy is attracting increasing attention in the treatment of cancers. In this work, PEGylated mesoporous SiO2 -coated gold nanostars (GNS@mSiO2 -PEG) were synthesized without using the cytotoxic surfactant cetyltrimethylammonium bromide as the template. Mesoporous nanostructures were obtained by poly(vinylpyrrolidone) protection of the outer silica shell and NaOH etching of the inner shell. GNS@mSiO2 -PEG exhibited good dispersity in medium and excellent photothermal effects. Loading capacity for the anticancer drug doxorubicin (DOX) was ∼17...
July 11, 2018: Journal of Drug Targeting
Andrew C Prince, Neel G Patel, Lindsay S Moore, Andrew S McGee, John C Ahn, Christopher D Willey, William R Carroll, Eben L Rosenthal, Jason M Warram
Intratumoral metabolic demands result in excessive angiogenic cytokine release leading to unorganized vasculature. Resultant fluid dynamics oppose blood flow and drug penetration due to a marked increase in interstitial fluid hydrostatic pressure. It is hypothesized that anti-angiogenic therapy may function to "prune" vasculature and lead to improved chemotherapeutic penetration. Subcutaneous, OSC19 tumor bearing mice (n = 5/dose/agent) were administered varying doses of an anti-mouse VEGFR2 (DC101) or an anti-mouse VEGFR3 (31C1) -3d, -1d, 0d, +1d, and +3d prior to 200μg of cetuximab fluorescently labeled with IRDye800CW...
July 4, 2018: Journal of Drug Targeting
Lalit Mohan Negi, Manu Jaggi, Anita K Verma, Sushama Talegaonkar
Multi Drug Resistance (MDR) of cancer cells is a constant threat to the clinically used drugs as well as new drug development. In present, work we aimed to assess in-vitro as well as in-vivo efficacy of the developed Imatinib loaded liposomes in MDR cancer. An array of tests was also carried out to comprehensively understand the bio-mechanism that enable these nanocarriers to modulate P-gp activity. Hyaluronic acid coated, Imatinib mesylate containing lipsomes (HA-LIPO-IM) were analysed through in-vitro and in-vivo studies in MDR cancer cells and tumour models...
July 4, 2018: Journal of Drug Targeting
Ji Hee Kang, Jinsung Cho, Young Tag Ko
The blood-brain barrier (BBB) is a limiting factor in nanoparticle drug delivery to the brain, and various attempts have been made to overcome it for efficient drug delivery. Nowadays, it was considered as further issue for brain-drug delivery that the nanoparticle delivered to brain through the BBB reach cancer cells in tumor tissue In this study, we investigated the effect of nanoparticle size on blood-brain tumor barrier (BBTB) permeation of fluorescence-labeled gold nanoparticles (AuNPs) in a mouse model of orthotopic glioblastoma multiforme (GBM), established by intracranial implantation of luciferase-expressing human glioblastoma U87MG cells...
July 4, 2018: Journal of Drug Targeting
Sepideh Zununi Vahed, Nazanin Fathi, Mohammad Samiei, Solmaz Maleki Dizaj, Simin Sharifi
Based on exceptional advantages of aptamers, increasing attention has been presented in the utilize of them as targeted ligands for cancer drug delivery. Recently, the progress of aptamer- targeted nanoparticles has presented new therapeutic systems for several types of cancer with decreased toxicity and improved efficacy. We highlight some of the promising formulations of aptamer-conjugated polymeric nanoparticles for specific targeted drug delivery to cancer cells. This review paper focuses on the current progresses in the use of the novel strategies to aptamer-targeted drug delivery for chemotherapy...
June 21, 2018: Journal of Drug Targeting
Kejing Lao, Naichun Ji, Xiaohua Zhang, Wenwei Qiao, Zhishu Tang, Xingchun Gou
Alzheimer's disease (AD) is a chronic neurodegenerative disease, which is considered as one of the most intractable medical problems with heavy social and economic costs. The current drugs for AD, including acetylcholinesterase inhibitors (AChEIs) and memantine, a NMDA receptor antagonist, only temporarily ameliorate cognitive decline, but are unable to stop or reverse the progression of dementia. This paper reviewed the recent advance in AD drug development. The drug discovery programs under clinical trials targeting cholinergic system, α7 nicotinic acetylcholine receptors (nAChRs), N-methyl-d-aspartate receptor (NMDAR), β-secretase, γ-secretase modulators, tau, inflammatory mediators and glucagon-like peptide-1 (GLP-1) were discussed...
June 20, 2018: Journal of Drug Targeting
Lingyun Yi, Yanan Zhang, Xiaoqun Shi, Xiyou Du, Xinyi Wang, Aihua Yu, Guangxi Zhai
In recent years, graphene oxide (GO) nanomaterials have attracted wide attention due to their large surface area, strong light sensitivity and good biocompatibility in cancer treatment. The rich oxygen-containing functional groups on the surface provide it with the opportunity to be modified by many functional molecules to expand biological applications and reduce toxicity. In this review, the properties of GO and the methods of surface modification are presented, and the toxicity of GO is analysed. In addition, the current applications of GO in cancer diagnoses and treatments including biological imaging, drug and gene delivery, phototherapy and imaging-mediated combination therapy are summarised...
June 17, 2018: Journal of Drug Targeting
Zhijie Wang, Wenqi Yuan, Bo Li, Xueming Chen, Yanjun Zhang, Chuanjie Chen, Mei Yu, Yucai Xiu, Wenhua Li, Jiangang Cao, Xin Wang, Wen Tao, Xiaoling Guo, Shiqing Feng, Tianyi Wang
The present study explored a key miRNA that plays a vital role in sciatic nerve conditioning injury promoting repair of injured dorsal column, and validated its function. Microarray analysis revealed miR-17-5p expression decreased sharply at 3, 7 and 14 days in the sciatic nerve conditioning injury group compared with the simple dorsal column lesion group. After miR-17-5p inhibition in DRG neurons, GAP-43 expression was upregulated and neurite growth was increased. STAT3 together with p-STAT3 showed opposite trends with miR-17-5p...
June 7, 2018: Journal of Drug Targeting
Y Han, X Li, C Ma, X Ji, T Li, X Zheng, J Zhang, J Yan, D Zhang, J Bai
MicroRNAs (miRNAs) are small, noncoding RNAs that have tissue- and cell-specific expression. They have the ability to regulate the malignant proliferation and transformation of tumor cells. The research focused on the expression and role of miR-1297 in melanoma. We firstly found that miR-1297 is up-regulated in melanoma tissues and cell lines. Functionally, phosphatase and tension homology deleted on chromsome ten gene (PTEN) was used as a potential target for miR-1297 and detected using Western blotting and immunohistochemistry (IHC)...
June 6, 2018: Journal of Drug Targeting
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