journal
https://read.qxmd.com/read/38512151/aptamer-as-a-targeted-approach-towards-treatment-of-breast-cancer
#1
REVIEW
Anjali Bisht, Shuvadip Bhowmik, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi
Aptamers, a novel type of targeted ligand used in drug delivery, have quickly gained popularity due to their high target specificity and affinity. Different aptamer-mediated drug delivery systems, such as aptamer-drug conjugate (ApDC), aptamer-siRNA, and aptamer-functionalized nanoparticle systems, are currently being developed for the successful treatment of cancer based on the excellent properties of aptamers. These systems can decrease potential toxicity and enhance therapeutic efficacy by targeting the drug moiety...
March 21, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38506620/comprehensive-molecular-and-clinical-insights-into-non-small-cell-lung-cancer-transformation-to-small-cell-lung-cancer-with-an-illustrative-case-report
#2
REVIEW
Kreso Tomic, Kristina Krpina, Lara Baticic, Miroslav Samarzija, Semir Vranic
Histologic transformation to small cell lung cancer (tSCLC) is a rare but increasingly recognized mechanism of acquired resistance to tyrosine kinase inhibitors (TKI) in patients with epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC). Beyond its acknowledged role in TKI resistance, histologic transformation to SCLC might be an important, yet under-recognized, mechanism of resistance in NSCLC treated with immunotherapy. Our review identified 32 studies that investigated tSCLC development in patients with EGFR -mutated NSCLC treated with TKI therapy and 16 case reports of patients treated with immunotherapy...
March 20, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38491993/the-potential-application-of-complement-inhibitors-loaded-nanosystem-for-autoimmune-diseases-via-regulation-immune-balance
#3
REVIEW
Yaya Wei, Jueshuo Guo, Tingting Meng, Ting Gao, Yaping Mai, Wenbao Zuo, Jianhong Yang
The complement is an important arm of the innate immune system, once activated, the complement system rapidly generates large quantities of protein fragments that are potent mediators of inflammation. Recent studies have shown that over-activated complement is the main proinflammatory system of autoimmune diseases (ADs). In addition, activated complements interact with autoantibodies, immune cells exacerbate inflammation, further worsening ADs. With the increasing threat of ADs to human health, complement-based immunotherapy has attracted wide attention...
March 16, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38469874/red-blood-membrane-camouflaging-bismuth-nanoflowers-designed-for-radio-photothermal-therapy-in-lung-cancer
#4
JOURNAL ARTICLE
Chang Liu, Yuanyuan Zhang, Jing Wen, Ji Liu, Meirong Huo, Yan Shen, Hao Luo, Hui Zhang
Radio-photothermal therapy is an effective modality for cancer treatment. To overcome the radio-resistance in the hypoxic microenvironment and improve the sensitivity of radiotherapy, metal nanoparticles, and radio-photothermal therapy are widely used in the research of improving the curative effect and reducing the side effects of radiotherapy. Here, we developed red blood membrane camouflaging bismuth nanoflowers (RBCM-BNF) with outstanding physiological stability and biodegradability for lung tumours. In vitro data proved that the RBCM-BNF had the greatest cancer cell-killing ability combined with X-ray irradiation and photo-thermal treatment...
March 12, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38445558/novel-ph-responsive-alginate-stabilized-curcumin-selenium-zif-8-nanocomposites-for-synergistic-breast-cancer-therapy
#5
JOURNAL ARTICLE
Emma Frouhar, Arghavan Adibifar, Maryam Salimi, Zahra Karami, Nasim Shadmani, Kobra Rostamizadeh
In this study, a novel selenium@Zeolitic imidazolate framework core/shell nanocomposite stabilized with alginate was used to improve the anti-tumor activity of curcumin. The developed alginate-stabilized curcumin-loaded selenium@Zeolitic imidazolate framework (Alg@Cur@Se@ZIF-8) had a mean diameter of 159.6 nm and polydispersity index < 0.25. The release of curcumin from the nanocarrier at pH 5.4 was 2.69 folds as high as at pH 7.4. The bare nanoparticles showed hemolytic activity of about 12.16% at a concentration of 500 µg/mL while covering their surface with alginate reduced this value to 5...
March 6, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38404239/enhancing-periodontal-defences-with-nanofiber-treatment-recent-advances-and-future-prospects
#6
REVIEW
Unnati Garg, Tanya Dua, Shreya Kaul, Neha Jain, Manisha Pandey, Upendra Nagaich
The term periodontal disease is used to define diseases characterized by inflammation and regeneration of the gums, cementum, supporting bone, and periodontal ligament. The conventional treatment involves the combination of scaling, root planning, and surgical approaches which are invasive and can pose certain challenges. Intrapocket administration of nanofibers can be used for overcoming challenges which can help in speeding up the wound repair process and can also be used to promote osteogenesis. To help make drug delivery more effective, nanofibers are an interesting solution...
February 26, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38385752/lauric-acid-based-thermosensitive-delivery-system-for-the-treatment-of-head-and-neck-squamous-cell-carcinoma
#7
JOURNAL ARTICLE
Maha AliAlghamdi, Mohamed Haider, Sebastiano Intagliata, Valeria PittalĂ , Jayalakshmi Jagal, Youssef Haider, Nasneen Althaf, Khaled Greish
Traditional treatments for head and neck squamous cell carcinoma (HNSCC) such as surgery, radiation therapy, and chemotherapy, often have severe side effects. Local delivery of chemotherapeutic agents can be a promising approach to minimize systemic toxicity and improve efficacy. Lauric acid (LA), was explored as a novel injectable thermosensitive drug reservoir as a depot for sustained release of anticancer drugs to treat HNSCC. LA was characterized in terms of melting temperature and gelation time. The efficacy of LA-based drug formulations was tested in vitro in a HNSCC cell line and in vivo in a mouse model of HNSCC...
February 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38385350/emerging-role-of-ferroptosis-in-diabetic-retinopathy-a-review
#8
REVIEW
Ruohong Wang, Suyun Rao, Zheng Zhong, Ke Xiao, Xuhui Chen, Xufang Sun
BACKGROUND: Diabetic retinopathy (DR) is a significant complication of diabetes and the primary cause of blindness among working age adults globally. The development of DR is accompanied by oxidative stress, characterised by an overproduction of reactive oxygen species (ROS) and a compromised antioxidant system. Clinical interventions aimed at mitigating oxidative stress through ROS scavenging or elimination are currently available. Nevertheless, these treatments merely provide limited management over the advanced stage of the illness...
February 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38321981/nanomedicine-targeted-anti-inflammatory-therapy-to-deal-with-the-crux-of-rheumatoid-arthritis
#9
REVIEW
Min An, Juntao Zhang, Xiaojie Zhang, Yumeng Zhao, Yanhua Liu
Rheumatoid arthritis is a chronic and complex autoimmune disease that is marked by an inflammatory response, synovial hyperplasia, vascularisation, fascial formation, cartilage and bone destruction, which can lead to joint deformity and even loss of function, ultimately affecting a person's health and quality of life. Although the pathogenesis of RA is unclear, growing evidence suggests that inflammation-associated cells infiltrate joints, causing tissue damage, inflammation and pain. This disruption in the balance between host tolerance and immune homeostasis the progression of RA...
February 16, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38345028/-in-vivo-evaluation-of-monoclonal-antibody-m4m-using-a-humanised-rat-model-of-stroke-demonstrates-attenuation-of-reperfusion-injury-via-blocking-human-trpm4-channel
#10
JOURNAL ARTICLE
Charlene Priscilla Poore, Shunhui Wei, Bo Chen, See Wee Low, Jeslyn Si Qi Tan, Andy Thiam-Huat Lee, Bernd Nilius, Ping Liao
BACKGROUND: Blocking Transient Receptor Potential Melastatin 4 (TRPM4) in rodents by our antibody M4P has shown to attenuate cerebral ischaemia-reperfusion injury. Since M4P does not interact with human TRPM4, the therapeutic potential of blocking human TRPM4 remains unclear. We developed a monoclonal antibody M4M that inhibited human TRPM4 in cultured cells. However, M4M has no effect on stroke outcome in wild-type rats. Therefore, M4M needs to be evaluated on animal models expressing human TRPM4...
February 12, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38328920/nanoparticles-toxicity-an-overview-of-its-mechanism-and-plausible-mitigation-strategies
#11
REVIEW
Nitin Sharma, Balak Das Kurmi, Dilpreet Singh, Sidharth Mehan, Kushagra Khanna, Ritu Karwasra, Shobhit Kumar, Amit Chaudhary, Vikash Jhakmola, Anjana Sharma, Sachin Kumar Singh, Kamal Dua, Dipti Kakkar
Over the last decade, nanoparticles have found great interest among scientists and researchers working in various fields within the realm of biomedicine including drug delivery, gene delivery, diagnostics, targeted therapy and biomarker mapping. While their physical and chemical properties are impressive, there is growing concern about the toxicological potential of nanoparticles and possible adverse health effects as enhanced exposure of biological systems to nanoparticles may result in toxic effects leading to serious contraindications...
February 8, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38315456/valeric-acid-reduction-by-chitosan-oligosaccharide-induces-autophagy-in-a-parkinson-s-disease-mouse-model
#12
JOURNAL ARTICLE
Rongsha Chen, Ke Li, Yinying Wang, Liyun Song, Ruohua Wang, Wenhui Fan, Ninghui Zhao, Wei Zou, Zhongshan Yang, Jinyuan Yan
Parkinson's disease (PD) is a central nervous system disease with the highest disability and mortality rate worldwide, and it is caused by a variety of factors. The most common medications for PD have side effects with limited therapeutic outcomes. Many studies have reported that chitosan oligosaccharide (COS) crossed blood brain barrier to achieve a neuroprotective effect in PD. However, the role of COS in PD remains unclear. The present study demonstrated that COS increased dopaminergic neurons in the substantia nigra (SN) and ameliorated dyskinesia in a PD mouse model...
February 5, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38315449/plant-based-natural-products-in-cancer-therapeutics
#13
REVIEW
Rohini Mahato, Dillip Kumar Behera, Biswajit Patra, Shradhanjali Das, Kulwant Lakra, Surya Narayan Pradhan, Sk Jahir Abbas, Sk Imran Ali
Various cells in our body regularly divide to replace old cells and dead cells. For a living cell to be growing, cell division and differentiation is highly essential. Cancer is characterized by uncontrollable cell division and invasion of other tissues due to dysregulation in the cell cycle. An accumulation of genetic changes or mutations develops through different physical (UV and other radiations), chemical (chewing and smoking of tobacco, chemical pollutants/mutagens), biological (viruses), and hereditary factors that can lead to cancer...
February 5, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38288679/resveratrol-loaded-microemulsion-based-thermosensitive-hydrogel-for-potential-topical-treatment-of-the-vaginal-inflammation
#14
JOURNAL ARTICLE
Jiaxin Liu, Liuqi Zhou, Huijing Cong, Jing Hu, Jingling Tang
Vaginal inflammation is a prevalent gynecological condition. If left untreated, it can potentially spread to the urinary and reproductive systems. In this study, we propose a resveratrol-loaded microemulsion-based thermosensitive hydrogel (Res-Me-Tsgel) and compare it with a chitosan hydrogel-based Res-Me-Cogel. The Res-Me-Tsgel we prepared is a transparent liquid solution at room temperature that rapidly forms a gel at 37 °C. Compared to Res solution and Res-Me, both Res-Me-Cogel and Res-Me-Tsgel demonstrate superior sustained release properties...
January 30, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38269855/insight-into-modulators-of-sphingosine-1-phosphate-receptor-and-implications-for-cardiovascular-therapeutics
#15
REVIEW
Yu-Xin Xie, Hui Yao, Jin-Fu Peng, Dan Ni, Wan-Ting Liu, Chao-Quan Li, Guang-Hui Yi
Cardiovascular disease is the leading cause of death worldwide, and it's of great importance to understand its underlying mechanisms and find new treatments. Sphingosine 1-phosphate (S1P) is an active lipid that exerts its effects through S1P receptors on the cell surface or intracellular signal, and regulates many cellular processes such as cell growth, cell proliferation, cell migration, cell survival, and so on. S1PR modulators are a class of modulators that can interact with S1PR subtypes to activate receptors or block their activity, exerting either agonist or functional antagonist effects...
January 25, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38269853/advances-in-herbal-polysaccharides-based-nano-drug-delivery-systems-for-cancer-immunotherapy
#16
REVIEW
Miao-Miao Han, Yi-Kai Fan, Yun Zhang, Zheng-Qi Dong
The boom in cancer immunotherapy has provided many patients with a better chance of survival, but opportunities often come with challenges. Single immunotherapy is not good enough to eradicate tumours, and often fails to achieve the desired therapeutic effect because of the low targeting of immunotherapy drugs, and causes more side effects. As a solution to this problem, researchers have developed several nano Drug Delivery Systems (NDDS) to deliver immunotherapeutic agents to achieve good therapeutic outcomes...
January 25, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38269592/dehydrocurvularin-loaded-mpeg-plga-nanoparticles-for-targeted-breast-cancer-drug-delivery-preparation-characterization-in-vitro-and-in-vivo-evaluation
#17
JOURNAL ARTICLE
Xuewei Cui, Zhong He, Jianjia Liang, Mulan Wei, Zhiyong Guo, Yiqing Zhou, Ye Qin, Zhangshuang Deng
Dehydrocurvularin (DCV) is a promising lead compound for anti-cancer therapy. Unfortunately, the development of DCV-based drugs has been hampered by its poor solubility and bioavailability. Herein, we prepared a DCV-loaded mPEG-PLGA nanoparticles (DCV-NPs) with improved drug properties and therapeutic efficacy. The spherical and discrete particles of DCV-NPs had a uniform diameter of 101.8 ± 0.45 nm and negative zeta potential of -22.5 ± 1.12 mV (pH =7.4), and its entrapment efficiency (EE) and drug loading (DL) were approximately 53...
January 25, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38258521/artificial-intelligence-for-skin-permeability-prediction-deep-learning
#18
JOURNAL ARTICLE
Kevin Ita, Sahba Roshanaei
BACKGROUND AND OBJECTIVE: Researchers have put in significant laboratory time and effort in measuring the permeability coefficient (Kp) of xenobiotics. In order to develop alternative approaches to this labor-intensive procedure, predictive models have been employed by scientists to describe the transport of xenobiotics across the skin. Most quantitative structure-permeability relationship (QSPR) models are derived statistically from experimental data. Recently, artificial intelligence-based computational drug delivery has attracted tremendous interest...
January 23, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38253594/state-of-the-art-drug-delivery-system-to-target-the-lymphatics
#19
REVIEW
Omkar T Khaire, Akshada Mhaske, Aprameya Ganesh Prasad, Waleed H Almalki, Nidhi Srivastava, Prashant Kesharwani, Rahul Shukla
The lymphatic system assumes a pivotal role in maintaining humoral equilibrium, regulating lipid metabolism, and orchestrating immune responses. Lymph nodes (LNs) are recognized as primary loci for tumor metastasis, significantly impacting patient prognosis. The strategic development of lymphatic-targeted systems holds promise for both disease treatment and vaccination effectiveness. In recent years, the convergence of nanotechnologies and innovative biomaterials has garnered substantial interest in crafting lymphatic-targeted drug delivery systems...
January 22, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38252517/harnessing-the-synergistic-potential-of-nk1r-antagonists-and-selective-cox-2-inhibitors-for-simultaneous-targeting-of-tnbc-cells-and-cancer-stem-cells
#20
REVIEW
Madhu Tanya Singh, Praveen ThaggikuppeKrishnamurthy, Sai Varshini M
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), rendering it unresponsive to endocrine therapy and HER2 targeted treatments. Though certain chemotherapeutics targeting the cell cycle have shown efficacy to a certain extent, the presence of chemotherapy-resistant cancer stem cells (CSCs) presents a significant challenge in tackling TNBC. Multiple lines of evidence suggest the upregulation of neuropeptide Substance P (SP), its NK-1 receptor (NK1R) and the Cyclooxygenase-2 (COX-2) enzyme in TNBC patients...
January 22, 2024: Journal of Drug Targeting
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