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Journal of Drug Targeting

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https://www.readbyqxmd.com/read/28436711/mir-33b-5p-sensitizes-gastric-cancer-cells-to-chemotherapy-drugs-via-inhibiting-hmga2-expression
#1
Xiaoyan Yang, Qian Zhao, Huali Yin, Xiaoyong Lei, Runliang Gan
MicroRNAs (miRNAs) are internal, noncoding, and ∼22 nt small RNAs that display cell- and tissue-specific expression. They play important regulatory roles in cell proliferation and chemo-sensitivity. This study focused on tumor-suppressive miR-33b-5p expression as well as its role in gastric cancer. MiR-33b-5p was found low expression in gastric cancer cell lines. Functionally, western blots and the luciferase reporter assay were used to confirme that HMGA2 was the potential target of miR-33b-5p. Next, we used CCK-8 kits to analyze the effect of miR-33b-5p combined chemotherapy drugs on cell inhibition rate, and flow cytometry to analyze cells apoptosis...
April 24, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28391715/curcumin-sensitizes-prostate-cancer-cells-to-radiation-partly-via-epigenetic-activation-of-mir-143-and-mir-143-mediated-autophagy-inhibition
#2
Jianbo Liu, Min Li, Yuewei Wang, Jianchao Luo
Curcumin has been reported as a radiosensitizer in prostate cancer. But the underlying mechanism is not well understood. In this study, we firstly assessed how curcumin affects the expression of miR-143/miR-145 cluster. Then, we investigated whether miR-143 is involved in regulation of radiosensitivity and its association with autophagy in prostate cancer cells. Our data showed that PC3, DU145 and LNCaP cells treated with curcumin had significantly restored miR-143 and miR-145 expression. Curcumin showed similar effect as 5-AZA-dC on reducing methylation of CpG dinucleotides in miR-143 promoter...
April 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28368667/one-step-formation-of-lipid-polyacrylic-acid-calcium-carbonate-nanoparticles-for-co-delivery-of-doxorubicin-and-curcumin
#3
Jianqing Peng, Shintaro Fumoto, Hirotaka Miyamoto, Yi Chen, Naotaka Kuroda, Koyo Nishida
A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this combination therapy require a consecutive drug loading process because of the different water-solubility of these drugs. The present study provides a strategy for the 'one-step' formation of nanoparticles encapsulating both Dox and Cur. We took advantage of polyacrylic acid (PAA) and calcium carbonate (CaCO3) to realise a high drug entrapment efficiency and pH-sensitive drug release using a simplified preparation method...
April 3, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28338354/functional-oligopeptide-as-a-novel-strategy-for-drug-delivery
#4
Yujie Ji, Hongzhi Qiao, Jiayu He, Weidong Li, Rui Chen, Jingjing Wang, Li Wu, Rongfeng Hu, Jinao Duan, Zhipeng Chen
Oligopeptides, a type of short peptide, which consist of two to twenty amino acids, exhibit a variety of biological functions in drug delivery systems, such as specific targeting, cell penetration, self-assembled capacity and responsiveness to the environment. In this review, we aim to highlight the importance of functional oligopeptides for nanomedical applications and put forward the views on the future development direction of oligopeptide medicines. Oligopeptides have gained wide attentions due to their inherent properties, but the lack of understanding the mechanisms of in vivo transport behavior is the biggest problem and challenge at the present stage...
March 24, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28316247/correction-to-huey-rachel-hawthorne-susan-the-potential-use-of-rabies-virus-glycoprotein-derived-peptides-to-facilitate-drug-delivery-into-the-central-nervous-system-a-mini-review
#5
(no author information available yet)
No abstract text is available yet for this article.
March 19, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28296507/lncrna-pvt1-epigenetically-silences-mir-195-and-modulates-emt-and-chemoresistance-in-cervical-cancer-cells
#6
Ching-Ju Shen, Ya-Min Cheng, Chiu-Lin Wang
The plasmacytoma variant translocation 1 gene (PVT1) is an oncogenic lncRNA with regulative effect on chemosensitivity in cervical cancer. However, the underlying mechanisms were not fully understood. In this study, HPV16 positive CaSki and SiHa cells were used as in-vitro cell model. Knockdown of HPV16 E7 significantly inhibited PVT1 and restored miR-195 expression. PVT1 directly interacts with EZH2 and the complex anchors in the promoter region of miR-195. PVT1 overexpression resulted in increased H3K27me3 levels in the miR-195 promoter region, while PVT1 knockdown decreased H3K27me3 levels in the promoter region...
March 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28294638/potential-targetability-of-multi-walled-carbon-nanotube-loaded-with-silver-nanoparticles-photosynthesized-from-ocimum-tenuiflorum-tulsi-extract-in-fertility-diagnosis
#7
Pradeep K Jha, Rakhi K Jha, Dilip Rout, Sathishkumar Gnanasekar, Suresh Vs Rana, Maidul Hossain
Nanocarrier mediated targeted delivery and biosensing in reproductive health care is a major exploratory domain. This work demonstrates the loading of silver nanoparticle (AgNP) inside the multiwalled Carbon nanotube(MWCNT) and their targetability to the intracellular part of the sperm cell for its further application in biosensing based infertility diagnosis. Ocimum tenuiflorum (tulsi extract) mediated photosynthesized AgNP exhibited spherical shape, 5-40nm size and surface plasmonic resonance at 430 nm...
March 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28286973/curcumin-inhibits-urothelial-tumor-development-by-suppressing-igf2-and-igf2-mediated-pi3k-akt-mtor-signaling-pathway
#8
Binqiang Tian, Yingmei Zhao, Tao Liang, Xuxiao Ye, Zuowei Li, Dongliang Yan, Qiang Fu, Yonghui Li
We have previously reported that curcumin inhibits urothelial tumor development in a rat bladder carcinogenesis model. In this study, we report that curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway. Curcumin inhibits IGF2 expression at the transcriptional level and decreases the phosphorylation levels of IGF1R and IRS-1 in bladder cancer cells and N-methyl-N-nitrosourea (MNU)-induced urothelial tumor tissue. Ectopic expression of IGF2 and IGF1R, but not IGF1, in bladder cancer cells restored this process, suggesting that IGF2 is a target of curcumin...
March 11, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28274130/%C3%AE-tocopherol-as-functional-excipient-for-resveratrol-and-coenzyme-q10-loaded-snedds-for-improved-bioavailability-and-prophylaxis-of-breast-cancer
#9
Sanyog Jain, Tanya Garg, Varun Kushwah, Kaushik Thanki, Ashish Kumar Agrawal, Chander Parkash Dora
The present study evaluates the prophylactic efficacy of α-tocopherol (α-TOH), resveratrol (RES), and coenzyme Q10 (CoQ10) co-loaded self-nanoemulsifying drug delivery system (α-TOH-RES-CoQ10 SNEDDS) in 7,12-Dimethylbenz[a]anthracene (DMBA) induced breast cancer model. SNEDDS formulation components were rationally selected and optimized for maximum drug loading by applying the design of experiments and further evaluated for stability in simulated gastrointestinal fluids, functional stability of antioxidants, in vitro release, Caco-2 cell uptake, oral bioavailability and prophylactic anticancer activity...
March 8, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28266884/intestinal-micropatches-for-oral-insulin-delivery
#10
Amrita Banerjee, Jessica Wong, Rohan Gogoi, Tyler Brown, Samir Mitragotri
Diabetes mellitus has become a major public health issue that has almost reached epidemic proportions worldwide. Injectable insulin has been typically utilized for management of this chronic disease. However, lack of patient compliance with injectable formulations has spurred the development of oral insulin formulations, which although appealing, face several delivery challenges. We have developed novel mucoadhesive intestinal patches, several hundred micrometers in dimension (micropatches) that address the challenges of oral insulin delivery...
March 7, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28277824/polymer-based-drug-delivery-the-quest-for-local-targeting-of-inflamed-intestinal-mucosa
#11
M Junaid Dar, Hussain Ali, Amjad Khan, Gul Majid Khan
Colon specific drug delivery has found important applications in the wide array of diseases affecting the lower intestinal tract. Recent developments and advancements in the polymer based colonic delivery ensure targeted therapeutics with reduced systemic adverse effects. Latest progress in the understanding of polymer science has decorated a polymer based formulation with a number of special features, which may prove effective in the localized drug targeting at specific sites of the intestine. Upon oral administration, polymeric vehicles or polymer coated formulations serve to protect the drug from premature release and degradation in the upper gastrointestinal tract...
February 23, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28277825/the-efficacy-of-wga-modified-daunorubicin-anti-resistant-liposomes-in-treatment-of-drug-resistant-mcf-7-breast-cancer
#12
Shuang Liu, Xiao-Li Song, Yan-Hong Wang, Xiao-Min Wang, Yao Xiao, Xin Wang, Lan Cheng, Xue-Tao Li
BACKGROUND: Breast cancer is the most common malignancy and remains a leading cause of cancer-related deaths in female. Chemotherapy failure of breast cancer is mainly associated with multidrug resistance of cancer cells. PURPOSE: The WGA modified daunorubicin anti-resistant liposomes were developed for circumventing the multidrug resistance and eliminating cancer cells. METHODS: WGA was modified on liposomal surface for increasing the intracellular uptake...
February 21, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28166440/malaria-treatment-using-novel-nano-based-drug-delivery-systems
#13
Uday Krishna Baruah, Kuppusamy Gowthamarajan, Ravisankar Vanka, Veera Venkata Satyanarayana Reddy Karri, Kousalya Selvaraj, Gifty M Jojo
We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the 21(st) century. Multiple drug resistance and non-specific drug targeting of the most widely used drugs are the main reasons/drawbacks behind the failure in malarial therapy. Dose related toxicity because of high doses is also a major concern. Therefore, to overcome these problems nano based drug delivery systems are being developed to facilitate site specific or target based drug delivery and hence minimising the development of resistance progress and dose dependent toxicity issues...
February 6, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28151022/enhanced-blood-brain-barrier-transport-of-vinpocetine-by-oral-delivery-of-mixed-micelles-in-combination-with-a-message-guider
#14
Jiaojiao Ding, Yujiao Sun, Jinfeng Li, Huimin Wang, Shirui Mao
The blood brain barrier represents an insurmountable obstacle for the therapy of central nervous system related diseases. Polymeric micelles have many desirable properties for brain targeting by oral delivery but the stability and targeting efficiency needs to be improved. In this study, it was demonstrated that binary micelle system can compensate the drawbacks of mono system by preparing mixed micelles in combination with PEG based copolymers. Here we explored a brain targeting drug delivery system via facile approaches using P123 based mixed micelles in combination with a message guider from traditional Chinese medicine, borneol, for oral delivery...
February 2, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28151021/novel-nanoparticulate-systems-for-lung-cancer-therapy-an-updated-review
#15
Asadullah Madni, Amna Batool, Sobia Noreen, Irsah Maqbool, Faizza Rehman, Prince Muhammad Kashif, Nayab Tahir, Ahmad Raza
Lung cancer is the leading cause of cancer-related deaths in the world. Conventional therapy for lung cancer is associated with lack of specificity and access to the normal cells resulting in cytotoxicity, reduced cellular uptake, drug resistance, and rapid drug clear from the body. The emergence of nanotechnology has revolutionized the treatment of lung cancer. The focus of nanotechnology is to target tumor cells with improved bioavailability and reduced toxicity. In the recent years, nanoparticulate systems have extensively been exploited in order to overcome the obstacles in treatment of lung cancer...
February 2, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28140698/recent-developments-in-trans-sialidase-inhibitors-of-trypanosoma-cruzi
#16
Muhammad Kashif, Antonio Moreno-Herrera, Edgar E Lara-Ramirez, Esther Ramírez-Moreno, Virgilio Bocanegra-García, Muhammad Ashfaq, Gildardo Rivera
Chagas is a lethal chronic disease that currently affects 8 to 10 million people worldwide, primarily in South and Central America. Trypanosoma cruzi trans-sialidase is an enzyme that is of vital importance for the survival of the parasite due to its key role in the transfer of sialic acid from the host to the parasite surface and it also helps the parasite combat the host´s immune system. This enzyme has no equivalent human enzyme, thus it has become an interesting target for the development of inhibitors that combat the parasite...
January 31, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28140697/pten-and-trail-genes-loaded-zein-nanoparticles-as-potential-therapy-for-hepatocellular-carcinoma
#17
Fathia Zaki El Sharkawi, Shaimaa Mohammed Ewais, Rania Hassan Fahmy, Laila Ahmed Rashed
Gene therapy is one of the recent approaches in treatment of hepatocellular carcinoma (HCC). Development of a vector or vehicle that can selectively and efficiently deliver the gene to target cells with minimal toxicity is an urgent demand. In the present study, Phosphatase and Tensin homolog (PTEN) and Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) genes were loaded to Zein nanoparticles (ZNPs). The formulated PTEN and TRAIL-loaded ZNPs were tested for their in-vitro and in-vivo potential antitumor efficacy using liver tumor cells (HepG2) and HCC-induced rats as animal model...
January 31, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28140690/effects-of-cell-penetrating-notch-inhibitory-peptide-conjugated-to-elastin-like-polypeptide-on-glioblastoma-cells
#18
Teuta Opačak-Bernardi, Jung Su Ryu, Drazen Raucher
Notch pathway was found to be activated in most glioblastomas (GBM), underlining the importance of Notch in formation and recurrence of GBM. In this study, a Notch inhibitory peptide, dominant negative MAML (dnMAML), was conjugated to Elastin-like polypeptide (ELP) for tumor targeted delivery. ELP is a thermally responsive polypeptide that can be actively and passively targeted to the tumor site by localized application of hyperthermia. This complex was further modified with the addition of a cell penetrating peptide, SynB1, for improved cellular uptake and blood-brain barrier penetration...
January 31, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28135859/recent-progress-in-drug-delivery-of-pluronic-p123-pharmaceutical-perspectives
#19
Li-Yan Zhao, Wan-Ming Zhang
This review focuses on recent investigations that used Pluronic P123 (P123) as pharmaceutical ingredients in vesicle, micelle, mixed micelle, in situ gel, tablet and emulsion, et al. The main results from these studies show that P123 can significantly increase the stability of incorporated hydrophobic drugs with enhanced in vitro cytotoxicity and cellular uptake of anticancer drugs. Moreover, modified forms of P123 with RGD, folate or other targeted marker have shown its therapeutic potentials in various types of tumors and cancers...
January 30, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28122462/current-treatment-strategies-and-nanocarrier-based-approaches-for-the-treatment-and-management-of-diabetic-retinopathy
#20
Kousalya Selvaraj, Kuppusamy Gowthamarajan, Veera Venkata Satyanarayana Reddy Karri, Uday K Barauah, Vanka Ravisankar, Gifty M Jojo
Diabetic retinopathy (DR) is a leading cause of blindness in all working age groups which contribute to patient's quality of life. Considering the anatomy and physiology of barriers in the eye, the treatment and management of pathologic ocular neovascularization in the posterior segment of the eye in DR is a challenging task. The current and emerging treatment strategies are discussed in this review for better understanding and treatment of the DR. Challenges in conventional therapy and recent developments in nanocarrier based approaches (polymeric, lipid nanoparticles, liposomes and dendrimers) and their advantages in targeting ocular tissues were also discussed in this review...
June 2017: Journal of Drug Targeting
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