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Journal of Drug Targeting

Chaopin Yang, Yue Li, Meng Du, Zhiyi Chen
As a non-invasive and real-time diagnostic technique, ultrasound has provided a novel strategy for targeted treatment. With the rapid development of ultrasonic technique and ultrasound contrast agents (UCAs), spatiotemporally controllable application of ultrasound with or without UCAs makes it possible for site-specific delivery of therapeutic agents and targeted modulation with minimal side effects, which indicated a promising therapy in clinical use. This review will describe the main mechanism of targeted therapy induced by ultrasound briefly, then focus on the current application of ultrasound mediated targeted therapy in various fields including tumor, cardiovascular disease, central nervous system, skeletal muscle system diseases and stem cells therapy...
April 16, 2018: Journal of Drug Targeting
Lin Yu, Yuqin Yao, Yuxi Wang, Shijie Zhou, Qinhuai Lai, Ying Lu, Yu Liu, Ruirui Zhang, Ruixue Wang, Chuang Liu, Lantu Gou, Xiaoxin Chen, Yamei Yu, Qiang Chen, Jinliang Yang
Antibody-drug conjugates (ADCs) have been successfully applied clinically as target drugs for cancer. In this study, anti-CD56 antibody-MMAE conjugate named Promiximab-MMAE was prepared by conjugation of microtubule inhibitor MMAE with Promiximab. The average drug-to-antibody ratio (DAR) of Promiximab-MMAE was 3.13 as analyzed by LC/MS/MS. The targeting capacity and affinity kinetics of Promiximab-MMAE were similar to that of Promiximab after conjugated with MMAE as tested by flow cytometry and biolayer interferometry analysis...
April 9, 2018: Journal of Drug Targeting
Liping Zhang, Yanan Shi, Yina Song, Dongyu Duan, Xuemei Zhang, Kaoxiang Sun, Youxin Li
Safe and effective oral delivery of peptide is a challenge. Here, we used exenatide and zinc ions (Zn2+ ) to form a complex to explore a meaningful oral-targeted drug-delivery system. Polyethylene glycol-poly(lactic acid-co-glycolic acid) (PEG-PLGA) was used to prepare nanoparticles (NPs) to escape the degradation caused by gastrointestinal enzymes. Transferrin (Tf) was used as a targeting group. PEG-PLGA-NPs and Tf-modified exenatide-Zn2+ -loaded NPs (Tf-PEG-PLGA-NPs) were uniformly sized spheres according to transmission electron microscopy...
April 5, 2018: Journal of Drug Targeting
Yue Chen, Ming Ji, Shen Zhang, Nina Xue, Heng Xu, Songwen Lin, Xiaoguang Chen
Inhibition of the signal transducer and activator of transcription 3 (STAT3) signaling pathway has been considered as a novel therapeutic strategy to treat human cancers with constitutively active STAT3. In this study, we screened 1563 compounds and identified Bt354 as a new small-molecule inhibitor of the STAT3 signaling pathway. The effect of Bt354 on STAT3 activity was initially screened and Bt354 significantly inhibited STAT3 activity in a dual luciferase assay. Bt354 inhibited the proliferation of cancer cells in a dose- and time-dependent manner...
March 29, 2018: Journal of Drug Targeting
Shuang Fu, Xiaodong Xu, Yu Ma, Shubiao Zhang, Shufen Zhang
Integrin αv β3 is restrictedly expressed on angiogenic blood vessels and tumor cells. It plays a key role in angiogenesis for tumor growth and metastasis. RGD peptide can specifically recognize the integrin αv β3 , which serve as targeted molecular for anti-angiogenesis strategies. Therefore, targeted delivery of therapeutics by RGD peptide based non-viral vectors to tumor vasculature and tumor cells is recognized as a promising approach for treating cancer. In this review, we illustrate the interaction between RGD peptide and integrin αv β3 from different perspectives...
March 22, 2018: Journal of Drug Targeting
Bohui Xu, Yan Xu, Gaoxing Su, Hongyan Zhu, Li Zong
Successful delivery of small interfering RNA (siRNA) into the cytoplasm of target cells relies on biocompatible and efficient vectors. In this study, a novel multifunctional core/shell nanoparticle [CS-SS-9R/BSA-c(RGDyK)] was developed to effectively deliver siVEGF to hepatocellular carcinoma cells (Bel-7402 cells). To improve the gene payload and transfection efficiency, a positively charged inner core (CS-SS-9R) was constructed by grafting nona-arginine (9R) onto chitosan (CS) using disulfide bonds. The negatively charged outer shell [BSA-c(RGDyK)] assembled on the surface of inner core by electrostatic forces that shielded high cationic charges and provided improved targeting...
March 22, 2018: Journal of Drug Targeting
Tulshidas S Patil, Ashwini S Deshpande, Shirish Deshpande, Pravin Shende
Tuberculosis (TB) is a disease caused by the pathogen Mycobacterium tuberculosis. Prolonged administration of high dose antibiotics using oral and injectable routes and their associated side effects, show limitations to successful treatment outcome of TB. Nanocarrier-based dry powder inhalers (DPIs) may provide a breakthrough as an alternative therapeutic approach because of their stable, non-invasive nature and ability to target the drug at the site of infection. The current review focuses on the roadmap of the respiratory system, drug deposition and targeting at the site of infection via pulmonary route...
March 21, 2018: Journal of Drug Targeting
Tian Li, Yafeng Shen, Li Su, Xiaoyan Fan, Fangxing Lin, Xuting Ye, Dianer Ding, Ying Tang, Yongji Yang, Changhai Lei, Shi Hu
Post-ischaemic heart failure is a major cause of death worldwide. Reperfusion of infarcted heart tissue after myocardial infarction has been an important medical intervention to improve outcomes. However, disturbances in Ca2+ and redox homeostasis at the cellular level caused by ischaemia/reperfusion remain major clinical challenges. In this study, we investigated the potential of adeno-associated virus (AAV)-9-mediated cardiac expression of a Type-2 ryanodine receptor (RyR2) degradation-associated gene, Presenilin 1 (PSEN1), to combat post-ischaemic heart failure...
March 21, 2018: Journal of Drug Targeting
Bo Zhang, Honglan Wang, Ting Jiang, Kai Jin, Zimiao Luo, Wei Shi, Heng Mei, Huafang Wang, Yu Hu, Zhiqing Pang, Xinguo Jiang
As one of the most intractable tumours, pancreatic ductal adenocarcinoma (PDA) has a dense extracellular matrix (ECM) which could increase solid stress within tumours to compress tumour vessels, reduce tumour perfusion and compromise nanomedicine delivery for PDA. Thus, alleviating solid stress represents a potential therapeutic target for PDA treatment. In this study, cyclopamine, a special inhibitor of the hedgehog signalling pathway which contributes a lot to ECM formation of PDA, was exploited to alleviate solid stress and improve nanomedicine delivery to PDA...
March 20, 2018: Journal of Drug Targeting
Zachary F Walls, Matthew Schwengels, Victoria Palau
The use of peptides in drug development has been hampered by their poor pharmaceutical properties, most notably their inability to reliably permeate biological membranes and lack of targeting. To overcome these disadvantages, the AMino acid Intracellular Delivery SysTem (AMIDST) was developed. This modular peptide-based delivery system confers cellular permeability and organelle-specific targeting for therapeutic peptides. As demonstrated in this study, the delivery of a HER2-binding peptide to the secretory organelles of breast cancer cells resulted in intracellular sequestration, a reduction in downstream signaling, and reduced viability compared to the delivery of a control peptide...
March 9, 2018: Journal of Drug Targeting
Shyh-Dar Li
No abstract text is available yet for this article.
February 19, 2018: Journal of Drug Targeting
Saghir Akhtar
No abstract text is available yet for this article.
February 19, 2018: Journal of Drug Targeting
Kui Li, Tian Hongqi
Cancer immunotherapy has been increasingly utilized to treat advanced malignancies. The signalling network of immune checkpoints has attracted considerable attention. Immune checkpoint inhibitors are revolutionizing the treatment options and expectations for patients with cancer. The reported clinical success of targeting the T-cell immune checkpoint receptors PD-1/PD-L1 has demonstrated the importance of immune modulation. Indeed, antibodies binding to PD-1 or PD-L1 have shown remarkable efficacy. However, antibody drugs have many disadvantages, such as their production cost, stability, and immunogenicity, and therefore, small-molecule inhibitors of PD-1 and its ligand PD-L1 are being introduced...
February 16, 2018: Journal of Drug Targeting
John C Kraft, Piper M Treuting, Rodney J Y Ho
The distributed network of lymph vessels and nodes in the body, with its complex architecture and physiology, presents a major challenge for whole-body lymphatic-targeted drug delivery. To gather physiological and pathological information of the lymphatics, near-infrared (NIR) fluorescence imaging of NIR fluorophores is used in clinical practice due to its tissue-penetrating optical radiation (700-900 nm) that safely provides real-time high-resolution in vivo images. However, indocyanine green (ICG), a common clinical NIR fluorophore, is unstable in aqueous environments and under light exposure, and its poor lymphatic distribution and retention limits its use as a NIR lymphatic tracer...
February 12, 2018: Journal of Drug Targeting
Asadullah Madni, Sobia Noreen, Irsah Maqbool, Faizza Rehman, Amna Batool, Prince Muhammad Kashif, Mubashar Rehman, Nayab Tahir, Muhammad Imran Khan
Graphene, the mother of all carbon materials has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, 2-dimensional structure and provides high surface area with adjustable surface chemistry to form hybrids. The present article provides a comprehensive review of ever-expanding application of graphene nanomaterials with different inorganic and organic materials in drug delivery and theranostics...
February 9, 2018: Journal of Drug Targeting
Mohammad Alsaggar, Dexi Liu
The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limit adequate drug disposition at the site of action and by off-target drug distribution to undesired tissues, which together result in the reduced effectiveness and increased side effects of therapeutic agents...
February 8, 2018: Journal of Drug Targeting
Jun-Tae Choi, Sangjin Park, Jung-Hwan Park
Microneedles (MN) containing cross-linked hyaluronic acid (X-linked HA) particulates were prepared to control the degradation and swelling behavior after transdermal drug delivery. The X-linked HA particulates were prepared by cross-linking HA chains and then passing the particulates through a sieve. Then, microneedles were prepared by micromolding method. The rheological properties of X-linked HA were studied. The penetration success rate, mechanical failure, and dissolution rate of microneedles containing only hyaluronic acid (HA MN) and microneedles containing X-linked HA were compared...
February 8, 2018: Journal of Drug Targeting
Derfogail Delcassian, Asha K Patel, Abel B Cortinas, Robert Langer
Over the last century there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins, and nucleic acids. The use of potent drugs which target specific organs, cells, or biochemical pathways, necessitates new tools which can enable controlled delivery and dosing of these therapeutics to their biological targets...
February 8, 2018: Journal of Drug Targeting
Carla Júnia Santos, Daniel Crístian Ferreira Soares, Carolina de Aguiar Ferreira, André Luís Branco de Barros, Armando da Silva Cunha Junior, Francisco Moura Filho
Angiogenesis, the complex process of formation of new blood vessels from pre-existing blood vessels, which involves the participation of several pro- and anti-angiogenic factors, is implicated in many physiological and pathological conditions. Nanoparticle-based anti-angiogenic activity at the tumour tissue, harnessed by the Enhanced Permeability and Retention Effect (EPR effect), could potentially become a breakthrough therapy to halt tumour progression. Herein, we evaluate the anti-angiogenic effect of ZnWO4 nanoparticles (NPs)...
January 31, 2018: Journal of Drug Targeting
Tianyuan Ci, Luo Yuan, Xiaoyan Bao, Yuting Hou, Hao Wu, Haifeng Sun, Dinglingge Cao, Xue Ke
Vulvovaginal candidiasis (VVC) is a typical kind of vaginal mucosal infection. Herein, we developed a novel vaginal delivery system of amphotericin B (AmB) nanosuspension loaded thermogel (AmB NPs/thermogel) utilizing pharmaceutical technique of high pressure homogenization and Poloxamer P407/P188 hydrogel. The stabilizer and hydrogel materials of the formulation were tested to maintain proper sol-gel transition as well as the relative stability of the particle size of AmB nanosuspension in the thermogel. The particle size of AmB nanosuspensions in the hydrogel was about 247 nm...
January 30, 2018: Journal of Drug Targeting
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