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Journal of Drug Targeting

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https://www.readbyqxmd.com/read/28644051/brief-overview-of-nanoparticulate-therapy-in-cancer
#1
Rajesh R Wakaskar
Nanoparticles govern an all-important role, in this day and age, in determining the tissue distribution of either hydrophobic or hydrophilic anti-cancer drugs by encapsulating them or by covalent attachment. The whole purpose is to systematically improve upon the existing anti-tumor efficacy of these drugs. Selective delivery of these chemotherapeutic agents to the compromised or diseased tissue is the key to avoid any potential toxicity problems. Certain types of nanoparticles, through various mechanisms such as active targeting or reversing multi-drug resistance, display immense potential in adding to the existing anti-tumor efficacy profile...
June 23, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28635335/a-novel-synergetic-targeting-strategy-for-glioma-therapy-employing-borneol-combination-with-angiopep-2-modified-dox-loaded-pamam-dendrimer
#2
Shunping Han, Hongyue Zheng, Yanping Lu, Yue Sun, Anhao Huang, Weidong Fei, Xiaowei Shi, Xiuling Xu, Jingjing Li, Fanzhu Li
Glioma is the most common primary malignant brain tumor and the effect of chemotherapy is hampered by low permeability across the blood-brain-barrier (BBB). Borneol is a time-honored 'Guide' drug in traditional Chinese medicine and has been proved to be capable of promoting free drugs into the brain efficiently, but there are still risks that free drugs, especially anti-glioma drugs, may be disassembled and metabolized before penetrating the BBB and caused the whole brain distribution. The purpose of this paper was to investigate whether borneol intervention could facilitate the BBB penetration and assist glioma treatment by combining with doxorubicin (DOX) loaded PAMAM dendrimers drug delivery system modified with Angiopep-2 (a ligand of the low-density lipoprotein receptor-related protein, which overexpress both in the BBB and gliomas)...
June 21, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28627280/the-targeting-effect-of-hm2e8b-nctd-liposomes-on-b-lineage-leukemia-stem-cells-is-associated-with-the-hlf-slug-axis
#3
Jingying Zhang, Diyin Shen, Min Jia, Haizhao Zhao, Yongmin Tang
To identify an agent with specific activity against B-lineage leukemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanized anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognize and kill B-LSCs in vitro, and to decrease non-specific cytotoxicity to untargeted cells. Hm2E8b-NCTD-liposomes selectively ablated B-LSCs through targeting hepatic leukemia factor (HLF), which is implicated in hematopoietic stem cell regulation and is overexpressed in LSCs...
June 19, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28583001/redox-triggered-mitoxantrone-prodrug-micelles-for-overcoming-multidrug-resistant-breast-cancer
#4
Hongzhi Qiao, Zhenzhu Zhu, Dong Fang, Yuan Sun, Chen Kang, Liuqing Di, Lei Zhang, Yahan Gao
Multidrug resistance (MDR) severely hinders the efficient chemotherapeutic treatments of cancer. d-α-Tocopherol polyethylene 1000 succinate (TPGS) based drug delivery system holds the potential of re-sensitizing resistant cancer cells. In this study, a TPGS prodrug containing both TPGS and mitoxantrone (MTO) via a disulphide bond was synthesised and assembled into micelle (TSMm) with a monodispersed diameter of 46.50 ± 1.12 nm. The disulphide bonds within the micelles could be cleaved in response to a high concentration of intracellular glutathione (GSH) after entering the tumour cells, leading a rapid release of MTO...
June 18, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28562134/contribution-of-nucleophosmin-overexpression-to-multidrug-resistance-in-breast-carcinoma
#5
Siying Chen, Ti Meng, Xiaowei Zheng, Jiangxia Cai, Weipeng Zhang, Haisheng You, Jianfeng Xing, Yalin Dong
Multidrug resistance (MDR) is a serious obstacle in breast cancer patients which limits chemotherapeutic drugs application. Our previous study confirmed that overexpression of nucleophosmin (NPM) was closely related to MDR in methotrexate-resistant breast cancer cells (MCF-7/MTX), and NPM could be a potential therapeutic target for chemoresistance. In this work, we aim to investigate NPM-mediated resistance mechanism in breast carcinoma. The NPM level was strongly positive in breast carcinoma tissues compared with adjacent normal samples, which was associated with lymph node metastasis...
June 14, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28535085/characterization-of-an-encapsulated-insulin-secreting-human-pancreatic-beta-cell-line-in-a-modular-microfluidic-device
#6
Argia Acarregui, Jesús Ciriza, Laura Saenz Del Burgo, Haritz Gurruchaga Iribar, José Yeste, Xavi Illa, Gorka Orive, Rosa M Hernández, Rosa Villa, Jose Luis Pedraz
Type I diabetes mellitus is characterised by the destruction of the insulin producing beta cells within the pancreas by the immune system. After the success of Edmonton protocol, islet transplantation has shown to be a promising therapy, but with the Achilles´ heel of the need of using immunosuppressive drugs. Currently, cell encapsulation technology represents a real alternative to protect transplanted islets from the host´s immune attack. Although preliminary in vitro studies with encapsulated cells have been traditionally performed under static conditions in terms of viability and efficiency, these static cultures do not represent a close approach to in vivo environments...
June 6, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28581827/therapeutic-efficacy-of-folate-receptor-targeted-amphiphilic-cyclodextrin-nanoparticles-as-a-novel-vehicle-for-paclitaxel-delivery-in-breast-cancer
#7
Nazlı Erdoğar, Güneş Esendağlı, Thorbjorn T Nielsen, Güldal Esendağlı-Yılmaz, Diğdem Yöyen-Ermiş, Batuhan Erdoğdu, Mustafa F Sargon, Hakan Eroğlu, Erem Bilensoy
Purpose The aim of this study is to test folate-conjugated cyclodextrin nanoparticles (FCD-1 and FCD-2) as a vehicle for reducing toxicity and increasing the antitumor efficacy of paclitaxel especially for metastatic breast cancer. Methods For the evaluation of PCX-loaded FCD nanoparticles, animal studies were realized in terms of survival rate, tumor size, weight change, metastazis and histopathological examination. Results FCD-1 displayed significant advantages such as efficient targeting of folate receptor positive breast cancer cells and having considerably lower toxicity compared to that of Cremophor®...
June 5, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28581825/targeted-mitochondria-antioxidants-therapeutic-implications-in-inflammatory-bowel-disease
#8
Abel Matondo, Sung Soo Kim
The role of the mitochondria, particularly its implications in cellular redox and oxidative balance is important for cell survival, and is involved in a variety of human diseases including Inflammatory Bowel Disease. In this review we address mitochondria physiology and reactive oxygen species as cognate to Inflammatory Bowel Disease. Several studies have reported altered mitochondria function in intestinal epithelium in Inflammatory Bowel Disease. However, mitochondrion significance in this disease has not been much investigated...
June 5, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28521529/potential-of-novel-drug-delivery-systems-in-the-management-of-topical-candidiasis
#9
Mahima Mathur, V Kusum Devi
High prevalence of topical fungal infections is perceived in majority of nations worldwide accounting for numerous serious systemic complications. Of several fungal infections, candidiasis is one of the widespread infections which is manifested due to localisation and proliferation of fungi. Present pharmacotherapy offers an effective treatment but possesses serious limitations like inadequate solubility, ineffectiveness in lowering diseased condition and patient incompliance. Several attempts to overcome these shortcomings and building suitable technology platforms for development of appropriate dosage forms which can enhance effectiveness, patient acceptability while maintaining safety, efficacy and affordability of drug delivery, have been made...
May 30, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28475385/preparation-of-chondroitin-sulfate-adipic-acid-dihydrazide-doxorubicin-conjugate-and-its-antitumour-characteristics-against-llc-cells
#10
Hiraku Onishi, Ai Fukasawa, Andang Miatmoko, Kumi Kawano, Yuri Ikeuchi-Takahashi, Yoshiyuki Hattori
Macromolecule-antitumour drug conjugates can reach tumour sites specifically via the enhanced permeability and retention (EPR) effect. It is desirable to release the drug efficiently from the conjugate at acidic pH in the tumour tissue or in the endosomes of cancer cells. In this study, we attempted to produce a carrier system with a labile chemical bond at acidic pH. Adipic acid dihydrazide (ADH)-chondroitin sulfate (CS) (termed CS-ACH) was synthesised by a two-step method, with the introduction of formyl groups followed by reductive amination using ADH...
May 16, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28452577/novel-nano-sized-liposome-encapsulated-polyamidoamine-dendrimer-derivatives-facilitate-tumour-targeting-by-overcoming-the-polyethylene-glycol-dilemma-and-integrin-saturation-obstacle
#11
Gang Li, Yan-Zhi Song, Zhen-Jun Huang, Kang Chen, Da-Wei Chen, Yi-Hui Deng
Drug delivery systems (DDSs) commonly employ arginine-glycine-aspartic acid (RGD) peptides with polyethylene glycol (PEG)-dependent enhanced permeability and retention (EPR) effect to optimise tumour-targeting. However, the PEG dilemma and integrin saturation obstacle are major challenges. To address these issues, we constructed a novel, nano-sized DDS by encapsulating doxorubicin (DOX)-loaded folic acid derivatives of polyamidoamine dendrimer (PAMAM G5.0) in cyclic RGD-tyrosine-lysine pentapeptide (c[RGDyK])-modified liposomes (RGD-SL[FND/DOX]), prepared using thin-film hydration, film-dispersion and hydration-sonication...
May 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28436711/mir-33b-5p-sensitizes-gastric-cancer-cells-to-chemotherapy-drugs-via-inhibiting-hmga2-expression
#12
Xiaoyan Yang, Qian Zhao, Huali Yin, Xiaoyong Lei, Runliang Gan
MicroRNAs (miRNAs) are internal, non-coding, and ∼22 nt small RNAs that display cell- and tissue-specific expression. They play important regulatory roles in cell proliferation and chemo-sensitivity. This study focused on tumor-suppressive miR-33b-5p expression as well as its role in gastric cancer. MiR-33b-5p was found low expression in gastric cancer cell lines. Functionally, western blots and the luciferase reporter assay were used to confirm that HMGA2 was the potential target of miR-33b-5p. Next, we used CCK-8 kits to analyze the effect of miR-33b-5p combined chemotherapy drugs on cell inhibition rate, and flow cytometry to analyze cells apoptosis...
May 11, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28462610/the-application-of-polysaccharide-based-nanogels-in-peptides-proteins-and-anticancer-drugs-delivery
#13
Lin Zhang, Jifei Pan, Shibo Dong, Zhaoming Li
Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs because of their characteristic properties like biodegradability, biocompatibility, stimuli-responsive behaviour, softness and swelling to help achieve a controlled, triggered response at the target site...
May 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28447892/intracellular-localisation-of-proteins-to-specific-cellular-areas-by-nanocapsule-mediated-delivery
#14
Huabin Wang, Ligang Chen, Xianchao Sun, Ailing Fu
Nanocapsules are promising carriers with great potential for intracellular protein transport. Although many studies have intended to improve cell uptake efficacy, there is an increasing interest in understanding of subcellular distribution of cargoes inside cells, which is essential for purposeful delivery of biomolecules into specific sites within cells. Herein, we interrogate the intracellular localisation of exogenous proteins, including fluorescein isothiocyanate (FITC)-labelled bovine serum albumin (BSA) and green fluorescent protein (GFP), mediated by specially designed nanocapsules...
May 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28438041/design-of-multifunctional-liposome-quantum-dot-hybrid-nanocarriers-and-their-biomedical-application
#15
Wenjing Qu, Wenbao Zuo, Na Li, Yanhui Hou, Zhihua Song, Guojing Gou, Jianhong Yang
Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have rich surface chemistry and unique optical properties that make them useful as probes or carriers for molecular diagnostics and therapeutics. However, their potential toxicity and instability in biological environments have puzzled scientific researchers. Much research effort has been devoted to encapsulation of QDs with liposomal hybrids to make them versatile nanocarriers for simultaneous therapeutics and diagnostics (theranostics) and considerable progress has been made over recent years...
May 8, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28447897/specific-hepatic-stellate-cell-penetrating-peptide-targeted-delivery-of-a-kla-peptide-reduces-collagen-accumulation-by-inducing-apoptosis
#16
Zhengrong Guo, Dong Li, Huanyan Peng, Jiwen Kang, Xiaoyu Jiang, Xiaoli Xie, Dianxing Sun, Huiqing Jiang
Liver fibrosis is an aberrant wound-healing process to chronic hepatic inflammation and is characterized by excessive accumulation of extracellular matrix (ECM) that is produced by activated hepatic stellate cells (HSCs). Thus, activated HSCs play a key role in the pathogenesis of liver fibrosis and are a potential target for the treatment of liver fibrosis. Herein, we report that a specific HSC-penetrating peptide reduced collagen accumulation by inducing the apoptosis of HSC-T6 cells. We first screened HSC-specific transduction peptides and identified a novel HSC-targeted cell-penetrating peptide (HTP) that specifically interacted with HSC-T6 cells...
May 7, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28368667/one-step-formation-of-lipid-polyacrylic-acid-calcium-carbonate-nanoparticles-for-co-delivery-of-doxorubicin-and-curcumin
#17
Jianqing Peng, Shintaro Fumoto, Hirotaka Miyamoto, Yi Chen, Naotaka Kuroda, Koyo Nishida
A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this combination therapy require a consecutive drug loading process because of the different water-solubility of these drugs. This study provides a strategy for the "one-step" formation of nanoparticles encapsulating both Dox and Cur. We took advantage of polyacrylic acid (PAA) and calcium carbonate (CaCO3) to realise a high drug entrapment efficiency (EE) and pH-sensitive drug release using a simplified preparation method...
May 2, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28391715/curcumin-sensitizes-prostate-cancer-cells-to-radiation-partly-via-epigenetic-activation-of-mir-143-and-mir-143-mediated-autophagy-inhibition
#18
Jianbo Liu, Min Li, Yuewei Wang, Jianchao Luo
Curcumin has been reported as a radiosensitizer in prostate cancer. But the underlying mechanism is not well understood. In this study, we firstly assessed how curcumin affects the expression of miR-143/miR-145 cluster. Then, we investigated whether miR-143 is involved in regulation of radiosensitivity and its association with autophagy in prostate cancer cells. Our data showed that PC3, DU145 and LNCaP cells treated with curcumin had significantly restored miR-143 and miR-145 expression. Curcumin showed similar effect as 5-AZA-dC on reducing methylation of CpG dinucleotides in miR-143 promoter...
April 20, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28338354/functional-oligopeptide-as-a-novel-strategy-for-drug-delivery
#19
Yujie Ji, Hongzhi Qiao, Jiayu He, Weidong Li, Rui Chen, Jingjing Wang, Li Wu, Rongfeng Hu, Jinao Duan, Zhipeng Chen
Oligopeptides, a type of short peptide, which consist of 2-20 amino acids, exhibit a variety of biological functions in drug delivery systems, such as specific targeting, cell penetration, self-assembled capacity and responsiveness to the environment. In this review, we aim to highlight the importance of functional oligopeptides for nanomedical applications and put forward the views on the future development direction of oligopeptide medicines. Oligopeptides have gained wide attentions due to their inherent properties, but the lack of understanding the mechanisms of in vivo transport behavior is the biggest problem and challenge at the present stage...
April 3, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28296507/lncrna-pvt1-epigenetically-silences-mir-195-and-modulates-emt-and-chemoresistance-in-cervical-cancer-cells
#20
Ching-Ju Shen, Ya-Min Cheng, Chiu-Lin Wang
The plasmacytoma variant translocation 1 gene (PVT1) is an oncogenic lncRNA with regulative effect on chemosensitivity in cervical cancer. However, the underlying mechanisms were not fully understood. In this study, HPV16 positive CaSki and SiHa cells were used as in vitro cell model. Knockdown of HPV16 E7 significantly inhibited PVT1 and restored miR-195 expression. PVT1 directly interacts with EZH2 and the complex anchors in the promoter region of miR-195. PVT1 overexpression resulted in increased H3K27me3 levels in the miR-195 promoter region, while PVT1 knockdown decreased H3K27me3 levels in the promoter region...
April 3, 2017: Journal of Drug Targeting
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