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Journal of Drug Targeting

Shyh-Dar Li
No abstract text is available yet for this article.
February 19, 2018: Journal of Drug Targeting
Saghir Akhtar
No abstract text is available yet for this article.
February 19, 2018: Journal of Drug Targeting
Kui Li, Tian Hongqi
Cancer immunotherapy has been increasingly utilized to treat advanced malignancies. The signalling network of immune checkpoints has attracted considerable attention. Immune checkpoint inhibitors are revolutionizing the treatment options and expectations for patients with cancer. The reported clinical success of targeting the T-cell immune checkpoint receptors PD-1/PD-L1 has demonstrated the importance of immune modulation. Indeed, antibodies binding to PD-1 or PD-L1 have shown remarkable efficacy. However, antibody drugs have many disadvantages, such as their production cost, stability, and immunogenicity, and therefore, small-molecule inhibitors of PD-1 and its ligand PD-L1 are being introduced...
February 16, 2018: Journal of Drug Targeting
Asadullah Madni, Sobia Noreen, Irsah Maqbool, Faizza Rehman, Amna Batool, Prince Muhammad Kashif, Mubashar Rehman, Nayab Tahir, Muhammad Imran Khan
Graphene, the mother of all carbon materials has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, 2-dimensional structure and provides high surface area with adjustable surface chemistry to form hybrids. The present article provides a comprehensive review of ever-expanding application of graphene nanomaterials with different inorganic and organic materials in drug delivery and theranostics...
February 9, 2018: Journal of Drug Targeting
Mohammad Alsaggar, Dexi Liu
The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limit adequate drug disposition at the site of action and by off-target drug distribution to undesired tissues, which together result in the reduced effectiveness and increased side effects of therapeutic agents...
February 8, 2018: Journal of Drug Targeting
Jun-Tae Choi, Sangjin Park, Jung-Hwan Park
Microneedles (MN) containing cross-linked hyaluronic acid (X-linked HA) particulates were prepared to control the degradation and swelling behavior after transdermal drug delivery. The X-linked HA particulates were prepared by cross-linking HA chains and then passing the particulates through a sieve. Then, microneedles were prepared by micromolding method. The rheological properties of X-linked HA were studied. The penetration success rate, mechanical failure, and dissolution rate of microneedles containing only hyaluronic acid (HA MN) and microneedles containing X-linked HA were compared...
February 8, 2018: Journal of Drug Targeting
Derfogail Delcassian, Asha K Patel, Abel B Cortinas, Robert Langer
Over the last century there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins, and nucleic acids. The use of potent drugs which target specific organs, cells, or biochemical pathways, necessitates new tools which can enable controlled delivery and dosing of these therapeutics to their biological targets...
February 8, 2018: Journal of Drug Targeting
John C Kraft, Piper M Treuting, Rodney J Y Ho
The distributed network of lymph vessels and nodes in the body, with its complex architecture and physiology, presents a major challenge for whole-body lymphatic-targeted drug delivery. To gather physiological and pathological information of the lymphatics, near-infrared (NIR) fluorescence imaging of NIR fluorophores is used in clinical practice due to its tissue-penetrating optical radiation (700-900 nm) that safely provides real-time high-resolution in vivo images. However, indocyanine green (ICG), a common clinical NIR fluorophore, is unstable in aqueous environments and under light exposure, and its poor lymphatic distribution and retention limits its use as a NIR lymphatic tracer...
February 1, 2018: Journal of Drug Targeting
Tianyuan Ci, Luo Yuan, Xiaoyan Bao, Yuting Hou, Hao Wu, Haifeng Sun, Dinglingge Cao, Xue Ke
Vulvovaginal candidiasis (VVC) is a typical kind of vaginal mucosal infection. Herein, we developed a novel vaginal delivery system of amphotericin B (AmB) nanosuspension loaded thermogel (AmB NPs/thermogel) utilizing pharmaceutical technique of high pressure homogenization and Poloxamer P407/P188 hydrogel. The stabilizer and hydrogel materials of the formulation were tested to maintain proper sol-gel transition as well as the relative stability of the particle size of AmB nanosuspension in the thermogel. The particle size of AmB nanosuspensions in the hydrogel was about 247 nm...
January 30, 2018: Journal of Drug Targeting
Nehru Sai Suresh Chalichem, Pindiprolu S S Sai Kiran, Duraiswamy Basavan
As well-known to the scientific community that Alzheimer`s disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition. Patient quality of life can be enhanced by targeting neurogenesis as a therapeutic paradigm. Preserving functional activity of SDF-1α and GLP-1 by DPPIV inhibition will enhance the homing of stem cells and modulates cell signaling pathways. The non-invasive approach presented in this article is a major advantage for managing AD, as regular/conventional stem-cell therapy necessarily relies on the application of regenerative stem cells exogenously...
January 30, 2018: Journal of Drug Targeting
Anirban Ganguly, Hari Krishna Reddy Rachamalla, Dwaipayan Bhattacharya, Keerti Bhamidipati, Abhishek Pal, Halley Gora Ravuri, Sumana Chakrabarti, Susanta Sekhar Adhikari, Rajkumar Banerjee
Function of steroid hormone estrogen that transactivates estrogen receptor (ER) is expressed in multiple organs. Except for malignancies of gynecological organs, ER remains largely unutilized as a target to treat cancers of ER-expressing brain, prostate, skin etc. We have previously developed estrogen targeting cationic lipid molecule (ES-C10), which showed targeted killing of ER+ breast and skin cancer cells. In this study, we explored the targeting ability of ES-C10 as a ligand as well as its additive killing effect (if any), when incorporated in two different liposomes (DCME and DCDE), carrying two anticancer molecules MCIS3 and DocetaxelTM respectively...
January 29, 2018: Journal of Drug Targeting
Shugo Yamashita, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
We developed a bone-targeting dendrimer for the delivery of anti-tumor agents and effective treatment of bone metastasis, in which alendronate (ALN), a bone-targeting moiety, is covalently bonded to a polyethylene glycol (PEG)-conjugated polyamidoamine (PAMAM) dendrimer (PEG-PAMAM-ALN). Approximately 7.0% and 21.9% of the administered doses of [111In]PAMAM and PEG-PAMAM-ALN accumulated in the bones within 180 min after intravenous injection in mice, respectively. [3H]-labeled methotrexate (MTX) rapidly disappeared from the blood, and bone distribution was found to be only 1...
January 29, 2018: Journal of Drug Targeting
Hong Li, Yang Liu, Lihua Chen, Qibing Liu, Shanshan Qi, Xinwei Cheng, Young B Lee, Chang-Ho Ahn, Deog Joong Kim, Robert J Lee
Folate receptor-targeted lipid-albumin nanoparticles (F-LAN) were synthesized for delivery of RX-0201, an antisense oligonucleotide (ASO) against the Akt1, which is currently in a Phase IIa clinical trial for metastatic renal cancer. These nanoparticles were composed of DOTAP/soyPC/TPGS/folate-PEG-DSPE (25:70:4:1 m/m), a cationic human serum albumin-pentaethylenehexamine (HSA-PEHA) conjugate, and RX-0201. The F-LAN-RX-0201 had a mean particle size of 108.6±5.8 nm, zeta potential of 10.5±3.2 mV, and ASO loading efficiency of 71...
January 29, 2018: Journal of Drug Targeting
Xun Feng, Yang Chen
Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that selectively attacks human joints. The common non-targeted treatment approaches lead to obvious side effect and systemtic complication for RA patients. Therefore, targeted drug delivery for treatment of RA has gained much attetntion in the past few years. In this paper, we reviewed the potential targets (folate receptor, angiogenesis, matrix metalloproteases, selectins, vasoactive intestinal peptide receptor, Fc-γ receptor) that could be utilized to facilitate the specific delivery of drugs to the inflammed synovium, and also presented different drug delivery systems for targeting RA, including the liposomes, various types of nanoparticles, polymeric micelles and the macromolecular prodrugs...
January 27, 2018: Journal of Drug Targeting
Carla Júnia Santos, Daniel Crístian Ferreira Soares, Carolina de Aguiar Ferreira, André Luís Branco de Barros, Armando da Silva Cunha, Francisco Moura Filho
Angiogenesis, the complex process of formation of new blood vessels from pre-existing blood vessels, which involves the participation of several pro and anti-angiogenic factors, is implicated in many physiological and pathological conditions. Nanoparticle-based anti-angiogenic activity at the tumor tissue, harnessed by the Enhanced Permeability and Retention Effect (EPR effect), could potentially become a breakthrough therapy to halt tumor progression. Herein, we evaluate the anti-angiogenic effect of ZnWO4 nanoparticles (NPs)...
January 22, 2018: Journal of Drug Targeting
Laurence Ho, Mehrdad Bokharaei, Shyh-Dar Li
Thermosensitive liposomes (TSLs) have been a prominent area of study in the discipline of tumour-targeted chemotherapeutics. The representative product of TSLs is ThermoDox® (DPPC/lyso-PC/PEG-lipid), which has advanced to Phase III clinical trials. Various groups have sought to develop a new TSL to improve upon the LTSL (lyso-lipid temperature-sensitive liposomes) formulation that is used to prepare ThermoDOX®. This review focuses on the development and recent update of an innovative TSL formulation, HaT-liposomes composed of DPPC and Brij78...
January 21, 2018: Journal of Drug Targeting
Masood A Khan, Ahmed N Aljarbou, Yousef H Aldebasi, Mohammed S Alorainy, Arshad H Rahmani, Hina Younus, Arif Khan
Natural Killer T (NKT) cells play an important role in host's anti-tumour immune response. Glycosphingolipids (GSLs) isolated from Sphingomonas paucimobilis have the ability to stimulate NKT cells. In this study, the activity of free GSLs or GSLs-incorporated liposomes (glycosphingosomes) was investigated against dimethyl-α-benzanthracene (DMBA)-induced tumours in mice. The anti-tumour immunity of GSLs- or glycosphingosomes-loaded bone marrow-derived dendritic cells (BMDCs) was investigated in tumour-bearing mice...
January 21, 2018: Journal of Drug Targeting
Sachin G Thakkar, Haiyue Xu, Xu Li, Zhengrong Cui
In an effort to improve the adjuvanticity of insoluble aluminum salts, we discovered that the adjuvant activity of aluminum salt nanoparticles is significantly stronger than aluminum salt microparticles, likely related to nanoparticle's stronger ability to directly activate NLRP3 inflammasome as the nanoparticles are more efficiently taken up by phagocytic cells. Endogenous signals such as uric acid from cell damage or death caused by the cytotoxicity of aluminum salts are thought to indirectly activate inflammasome, prompting us to hypothesize that the potent adjuvant activity of aluminum salt nanoparticles is also related to their ability to stimulate uric acid production...
January 15, 2018: Journal of Drug Targeting
Rui-Jun Ju, Lan Cheng, Xiao Qiu, Shuang Liu, Xiao-Li Song, Xiao-Ming Peng, Teng Wang, Cui-Qing Li, Xue-Tao Li
BACKGROUND: Breast cancer is an alarming global public health problem and a main cause of cancer-related death in women. Systemic chemotherapy is the most widely used treatment for breast cancer. However, current chemotherapy treatments are far from desirable due to poor targeting specificity, severe side effects, and vasculogenic mimicry (VM). PURPOSE: Hyaluronic acid (HA) modified daunorubicin plus honokiol cationic liposomes were prepared and characterized for treatment of breast cancer by eliminating VM...
January 15, 2018: Journal of Drug Targeting
Xue-Wei Cao, Xu-Zhong Yang, Xuan Du, Long-Yun Fu, Tao-Zhu Zhang, Han-Wen Shan, Jian Zhao, Fu-Jun Wang
Cell-penetrating peptide (CPP) is used for the delivery of biomacromolecules across the cell membrane and is limited in cancer therapy due to the lack of cell selectivity. Epidermal growth factor receptor (EGFR) has been widely used in clinical targeted therapy for tumors. Here we reported a novel tumor targeting cell-penetrating peptide (TCPP), EHB (ELBD-C6H) with 20-fold and 3000-fold greater transmembrane ability and tumor cell selectivity than our previously reported S3-HBD and classic CPP TAT, respectively...
January 5, 2018: Journal of Drug Targeting
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