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Ocular Immunology and Inflammation

Ramandeep Chhabra, Shi Zhuan Tan, Leon Au, Anne Fiona Spencer, Cecilia H Fenerty, Nicholas P Jones
PURPOSE: This study investigated the efficacy and safety of Baerveldt glaucoma implants (BGI) in adults with uveitic glaucoma (UG) at the Manchester Uveitis Clinic. METHODS: This was a retrospective study of 42 patients with UG who underwent BGI implantation between 2006 and 2015. Primary outcome measures were intraocular pressure (IOP) reduction and number of medications at 5-year follow-up. Three IOP success criteria were chosen: 1.IOP ≤21 mmHg and ≥20% reduction from baseline 2...
September 13, 2018: Ocular Immunology and Inflammation
Xiu Ling Tan, Sophia Seen, Parthopratim Dutta Majumder, Sudha K Ganesh, Aniruddh Soni, Jyotirmay Biswas, Kanika Aggarwal, Padmamalini Mahendradas, Vishali Gupta, Ho Su Ling, Stephen Teoh, Carlos Pavesio, Rupesh Agrawal
OBJECTIVE: To analyze the demographic profile, treatment, and visual outcome of the patients with sympathetic ophthalmia (SO) in a multicenter collaborative retrospective cohort study. METHODS: Medical records of the patients with SO from UK, Singapore, India were reviewed for history of ocular trauma or surgery and subsequent development of uveitis consistent with SO, presenting symptoms, treatment, and visual outcomes. RESULTS: A total of 130 patients were diagnosed with SO during the study period...
September 12, 2018: Ocular Immunology and Inflammation
Caiyun You, Halea Meese, Andrew Stephenson, Alyssa Montieth, Lina Ma, Mikhail Hernandez, Buraa Kubaisi, Sarah Syeda, C Stephen Foster
PURPOSE: To review early withdrawal of immunomodulatory therapy (IMT) for birdshot retinochoroidopathy (BSRC). DESIGN: Retrospective case-series of sixteen patients with Human-leukocyte-antigen-A29-positive BSRC treated with IMT ≥ 1 year and discontinued prior to achieving durable remission, observed ≥ 6 months off IMT. RESULTS: Mean duration on IMT was 42.4 months. At discontinuation, quiescence was achieved in 75.0% of eyes. Subjects off IMT for 6 months, 1 year, and 3 years showed quiescence in 75...
September 12, 2018: Ocular Immunology and Inflammation
Abhishek Sheemar, Shreyas Temkar, Brijesh Takkar, Rita Sood, Sanjeev Sinha, Rohan Chawla, Rajpal Vohra, Pradeep Venkatesh
AIM: To evaluate patterns of retinal vasculitis with ultra-wide field imaging (UWF) and ascertain the risk factors for retinal neovascularization. METHODS: Consecutive patients of retinal vasculitis were included prospectively. Patients with retinal vasculitis secondary to uveitis were excluded. UWF was done for all the patients. Retinal involvement was classified into three zones and area of capillary non-perfusion was stratified into clock hours. RESULTS: Two hundred patients were included, 85% (n = 170) were male...
September 12, 2018: Ocular Immunology and Inflammation
Seyedeh Maryam Hosseini, Sina Shirzad, Mehdi Ghasemi
PURPOSE: To report a rare case of relapsing polychondritis with bilateral panuveitis as the first presentation of systemic disease Methods: A 26-year-old female presented with bilateral decreased vision, red eye and ocular pain underwent complete ocular examination, retinal imaging and systemic investigation. RESULTS: Investigations revealed bilateral panuveitis associated with keratitis, retinal hemorrhages and retinal vasculitis. Following systemic work-ups and the pinna cartilage biopsy, diagnosis of relapsing polychondritis was made...
September 7, 2018: Ocular Immunology and Inflammation
Mohit Dogra, Garvit Bhutani, Vishali Gupta
PURPOSE: Fungal endophthalmitis following pars plana vitrectomy with silicone oil tamponade is an infrequent entity. Filamentous fungi like aspergillus are generally associated with endophthalmitis. Mucor is a rarely implicated pathogen in cases of endophthalmitis with only two reported cases in medical literature. Both these cases had uncontrolled diabetes which predisposed them to develop mucor endophthalmitis. METHODS: We report a non-diabetic patient who developed mucor endophthalmitis after uneventful vitreous surgery for myopia associated retinal detachment...
September 7, 2018: Ocular Immunology and Inflammation
Ilaria Testi, Maria Sofia Tognon, Vishali Gupta
PURPOSE: To emphasize the different manifestations of ocular involvement in Whipple disease with challenge in establishing the diagnosis as clinical, laboratory, and histological features could mimic other uveitis entities. METHODS: Case reports of three patients. RESULTS: The first patient was an African male suffering from a chronic bilateral keratoconjunctitivitis that was initially misdiagnosed as a chronic allergic conjunctivitis. The second patient was an Italian female who presented with bilateral vitritis, whereas the third patient was an Italian male suffering from a chronic bilateral panuveitis...
September 7, 2018: Ocular Immunology and Inflammation
Canan Asli Utine, Michael Stern, Esen Karamursel Akpek
PURPOSE: To assess differential roles of inflammatory cells in pathophysiology of severe atopic keratoconjunctivitis (AKC) and evaluate immunomodulatory effects of topical cyclosporine A (CsA). METHODS: A total of 10 patients with severe, steroid-dependent/resistant chronic active AKC were treated using frequent topical CsA 0.05% as monotherapy for 2 months. Conjunctival biopsy specimens before and after treatment were examined using immunohistochemistry. A total of 10 healthy age-matched adults served as the control group...
September 6, 2018: Ocular Immunology and Inflammation
Chui-Lien Tsen, Yao-Shen Chen, Kuan-Sheng Wu, Hung-Chin Tsai, Ya-Hsin Chen, Ying-Yen Lee, Shwu-Jiuan Sheu
PURPOSE: To investigate the prevalence and characteristics of ocular manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in patients treated at a tertiary referral center in Taiwan during a time of highly active antiretroviral therapy (HAART) Materials and Methods: A retrospective cohort study in Taiwan was performed between January 2006 and July 2016. Ocular examination and systemic information were recorded from the HIV-infected patients. RESULTS: 1242 patients with HIV/AIDS were identified...
September 6, 2018: Ocular Immunology and Inflammation
Rupesh Agrawal, Dinesh Visva Gunasekeran, Aniruddha Agarwal, Ester Carreño, Kanika Aggarwal, Bhaskar Gupta, Dhananjay Raje, Somasheila I Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A Goldstein, Carl P Herbort, Talin Barisani-Asenbauer, Julio J González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Joanne Lord, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, John Kempen, Emmett T Cunningham, Andres Rousselot, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
PURPOSE: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). METHODS: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. RESULTS: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13...
August 29, 2018: Ocular Immunology and Inflammation
Ana Luiza Biancardi, Haroldo Vieira de Moraes
PURPOSE: To describe two cases of anterior and intermediate uveitis following yellow fever vaccination with fractional dose. METHODS: Case report. RESULTS: Case 1: A 35 year-old healthy woman presented with unilateral anterior uveitis 10 days after the yellow fever vaccination. Testing excluded infectious and rheumatic diseases and the episode was fully recovered after a short course of topical treatment. Case 2: A 21 year-old previously healthy woman presented with blurred vision in the left eye (OS) 14 days after the yellow fever vaccination...
August 28, 2018: Ocular Immunology and Inflammation
Parthopratim Dutta Majumder
To describe a case of presumed tuberculous sclerokeratitis which presented with anterior uveitis and hypopyon Methods: A retrospective chart review Results: A 23-year-old female presented with nodular scleritis, peripheral corneal opacities, and severe anterior chamber reaction with hypopyon. Her Mantoux test and interferon gamma release assay were positive and high-resolution computerized tomography of chest revealed right hilar lymphadenopathy. Aqueous aspirate from anterior chamber paracentesis of her right eye was negative for Mycobacterium tuberculosis genome...
August 27, 2018: Ocular Immunology and Inflammation
Claudia Fabiani, Antonio Vitale, Donato Rigante, Giacomo Emmi, Giuseppe Lopalco, Gerardo Di Scala, Jurgen Sota, Ida Orlando, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
PURPOSE: To identify factors associated with sustained response to interleukin (IL)-1 inhibition among demographic, clinical and therapeutic data in patients with Behçet disease (BD). METHODS: BD patients treated with anakinra or canakinumab were enrolled. Patients were divided into two groups according to the clinical response: group 1 included subjects showing a treatment duration of at least 52 weeks and no secondary inefficacy during the first follow-up year; the remaining patients were included in the group 2...
August 27, 2018: Ocular Immunology and Inflammation
Eiman Abd El Latif, Wahib Fayez Goubran, Emad El Din M El Gemai, Ahmed E Habib, Ahmed M Abdelbaki, Hatem Ammar, Mouamen Seleet
PURPOSE: To report the pattern of childhood-onset uveitis observed in Egypt from May 2010 to May 2017 Methods: Retrospective evaluation of the data of all patients with uveitis diagnosed before the age of 16 and visiting uveitis referral clinics in 5 Egyptian Governorates (Alexandria, Cairo, Al Bohayra (Damanhour), Al Gharbeya (Tanta), and Sohag) between May 2010 and May 2017. RESULTS: A total of 413 uveitis patients were enrolled. These included 219 male and 194 female patients...
August 27, 2018: Ocular Immunology and Inflammation
Abdulrahman F AlBloushi, Abdullah M Alfawaz, Saad A Al-Dahmash, Adi M Al Owaifeer, Saad H AlEnezi, Abdulmajeed S Al-Fakhri, Priscilla W Gikandi, Ahmed M Abu El-Asrar
PURPOSE: To investigate incidence, risk factors, and surgical outcomes of cataract among uveitis patients. METHODS: Retrospective review of 1000 patients (1582 eyes). RESULTS: At initial presentation, cataract was diagnosed in 290 (18.3%) eyes and was most common in eyes with anterior uveitis. Fuchs' uveitis, herpetic uveitis, and presumed tuberculous uveitis were leading clinical entities associated with cataract at presentation. During follow-up, cataract developed in additional 200 (12...
August 24, 2018: Ocular Immunology and Inflammation
Nesrin Büyüktortop Gökçınar, Ayşe Anıl Karabulut, Zafer Onaran, Erhan Yumuşak, Fatma Azize Budak Yıldıran
PURPOSE: To investigate the role of innate immunity in ocular rosacea. METHODS: Thirty-two patients with ocular rosacea patients (group-1) and 28 healthy volunteers (group-2) who served as controls were enrolled in the study. Tear function parameters were assessed, conjunctival impression cytology was performed and tear samples were collected. Human-neutrophil-peptides (HNP) 1-3 and human-beta-defensin-2 (hBD-2) levels were measured in tears by using ELISA tests...
August 24, 2018: Ocular Immunology and Inflammation
Aniruddha Agarwal, Alessandro Invernizzi, Sahil Jain, Alessandra Acquistapace, Agostino Riva, Aman Sharma, Vishali Gupta, Ramandeep Singh
No abstract text is available yet for this article.
August 24, 2018: Ocular Immunology and Inflammation
Steven Carter, Kate Xie, Darren Knight, Donald Minckler, Sanjay Kedhar
PURPOSE: To describe a case of granulomatous anterior uveitis and histologically confirmed chronic granulomatous conjunctivitis in the presence of common variable immune deficiency (CVID). METHODS: Interventional case report. RESULTS: A 72-year-old female with a history of CVID treated with regular intravenous immunoglobulin (IVIG) infusions developed chronic conjunctivitis and granulomatous anterior uveitis. She responded to topical steroids, but there was recurrence upon cessation of steroid therapy...
August 24, 2018: Ocular Immunology and Inflammation
Guoxiang Song, Jinxian Huang, Yaling Deng, Zhangyi Liang, Yannan Lin
PURPOSE: The purpose of the article is to investigate the contribution of calprotectin and factors in toll-like receptor 4/nuclear factor-κB/myeloid differentiation factor 88 (TLR4/NF-κB/MyD88) pathway in patients with idiopathic acute anterior uveitis (IAAU). METHODS: In total, 72 patients with IAAU and 56 healthy individuals were enrolled. Serum calprotectin, TLR-4, and MyD88 were determined. Best-corrected visual acuity, uveitis activity grading, and macular thickness measured by optical coherence tomography were performed...
August 15, 2018: Ocular Immunology and Inflammation
Ziya Ayhan, Mahmut Kaya, Taylan Ozturk, Gul Arikan, Merih Birlik
PURPOSE: To analyse the association between skin score with corneal biomechanics and dry eye tests in systemic sclerosis (SSc). METHODS: 112 cases (limited SSc (lcSSc), n=50; diffuse SSc  (dcSSc), n=32; controls, n=30) were included in the study. Corneal hysteresis (CH), corneal resistance factor (CRF), Schirmer 1, 2 tests, OSDI score and modified Rodnan skin score (mRSS) were evaluated. RESULTS: There was correlation between the mRSS and CH (p = 0...
August 15, 2018: Ocular Immunology and Inflammation
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