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Ocular Immunology and Inflammation

Annamaria Nagy, Aniko Rentka, Gabor Nemeth, Hassan Ziad, Gabriella Szücs, Zoltán Szekanecz, Rudolf Gesztelyi, Judit Zsuga, Zsuzsa Aszalos, Peter Szodoray, Adam Kemeny-Beke
PURPOSE: Corneal involvement in systemic sclerosis (SSc) is rare, but due to rich collagen composition cornea is especially vulnerable to connective tissue diseases. Therefore, our aim was to evaluate corneal parameters of SSc patients. METHODS: The study included 32 SSc patients and 39 control subjects with no ocular symptoms or ocular surface disorders. All study participants underwent Pentacam evaluation and objective signs of dry eye disease (DED), and clinical parameters were evaluated...
July 17, 2018: Ocular Immunology and Inflammation
Hiroshi Goto, Masahiro Zako, Kenichi Namba, Noriyasu Hashida, Toshikatsu Kaburaki, Masanori Miyazaki, Koh-Hei Sonoda, Toshiaki Abe, Nobuhisa Mizuki, Koju Kamoi, Antoine P Brézin, Andrew D Dick, Glenn J Jaffe, Quan Dong Nguyen, Noritaka Inomata, Nisha V Kwatra, Anne Camez, Alexandra P Song, Martina Kron, Samir Tari, Shigeaki Ohno
PURPOSE: Report global adalimumab safety and efficacy outcomes in patients with non-infectious uveitis. METHODS: Adults with non-infectious intermediate, posterior, or panuveitis were randomized 1:1 to receive placebo or adalimumab in the VISUAL I (active uveitis) or VISUAL II (inactive uveitis) trials. Integrated global and Japan substudy results are reported. The primary endpoint was time to treatment failure (TF). RESULTS: In the integrated studies, TF risk was significantly reduced (hazard ratio [95% CI]) with adalimumab versus placebo (VISUAL I: HR = 0...
July 17, 2018: Ocular Immunology and Inflammation
Anindya K Majumdar, Amitabh Kumar, Rupak Roy, Parthopratim Dutta Majumder
PURPOSE: To analyse clinical profile of the patients with HLA B 27- associated uveitis in a tertiary care eye hospital in Eastern India Method: Retrospective analysis of 61 eyes of 43 patients with HLA B27- associated uveitis between 2015 and 2016. RESULT: We observed a male predominance (67%), and more unilateral involvement (58%) in our patients. The mean age of presentation was 44.7 ±11.7 years. Significant vitritis and macular edema were noted in 14 and 7 eyes respectively...
July 16, 2018: Ocular Immunology and Inflammation
Ilaria Testi, Maria Sofia Tognon, Vishali Gupta
PURPOSE: To emphasize the challenge in the diagnosis of granulomatous uveitis, distinguishing clinical, laboratory, and histological features of tuberculosis, sarcoidosis, and borderline entities. METHODS: Case report. RESULTS: A patient coming from tuberculosis endemic area with granulomatous uveitis and generalized lymphadenopathy was first diagnosed with possible intraocular tuberculosis, based on the presence of suggestive clinical signs, caseous central necrosis in lymph node biopsy, and documented exposure to TB...
July 11, 2018: Ocular Immunology and Inflammation
Steven Yeh, Jessica G Shantha, Brent Hayek, Ian Crozier, Justine R Smith
In the wake of the international Ebola virus disease (EVD) outbreak from 2014 to 2016, thousands of EVD survivors are at-risk of ophthalmic manifestations, as well as systemic sequelae including arthralgias, abdominal pain, psychosocial stressors, and risk of viral persistence in immune-privileged organs. Ophthalmic manifestations in EVD survivors include a spectrum of disease ranging from anterior uveitis to panuveitis, which confers a high risk of vision impairment and blindness, particularly given the access and resource limitations for ophthalmic subspecialty care in West Africa...
July 11, 2018: Ocular Immunology and Inflammation
Boya Lei, Rui Jiang, Ruiping Gu, Gezhi Xu, Fang Song, Min Zhou
PURPOSE: To summarize the characteristics of endogenous fungal endophthalmitis (EFE) after genitourinary procedures. METHODS: Medical records of patients diagnosed with EFE after genitourinary procedures from a single center during a 6-year period were reviewed. RESULTS: Nineteen eyes of 15 patients were included. The interval time between procedure to symptom was 3.6 ± 3.6 weeks. As the initial treatment, 9/19 eyes underwent primary vitrectomy and 10/19 eyes underwent intravitreal antifungal injection ...
July 11, 2018: Ocular Immunology and Inflammation
Rupesh Agrawal, Bryan Ang, Praveen Kumar Balne, Christopher Richards, Thomas Smart, João Cardoso, David Shima, Philip H Jones, Carlos Pavesio
PURPOSE: To investigate differences in red blood cell (RBC) deformability between birdshot chorioretinopathy (BCR) subjects and matched controls, and to postulate its relationship with lack of vascular occlusion in BCR. METHODS: In a single center, prospective, non-randomized mechanistic study, blood samples were collected from eight healthy controls and nine BCR patients, and subjected to biochemical and hematological tests, as well as RBC indices assessment using dual-beam optical tweezers...
July 9, 2018: Ocular Immunology and Inflammation
Masoomeh Mohebbi, Masoud Mirghorbani, Ali Banafshe Afshan, Mohsen Towfighi
Ocular lichen planus (LP) is a rare disease which has been increasingly reported in the literature in the last two decades involving conjunctiva, cornea, and lacrimal drainage system. Most reported cases of ocular LP are cicatricial conjunctivitis with subepithelial fibrosis, fornix shortening, and symblepharon formation. It is not clear whether corneal involvement is a primary event or secondary to these changes. Topical cyclosporine and corticosteroid can be considered as first-line therapy in ocular surface involvement, while treatment regimen in more aggravated disease should be boosted with systemic immunosuppressives...
July 9, 2018: Ocular Immunology and Inflammation
Akash Gupta, Edmund Tsui, Soshian Sarrafpour, Carol M Lee, Yasha S Modi
PURPOSE: To describe a case of endogenous endophthalmitis from Streptococcus dysgalactiae subspecies equisimilis in the setting of an aortic valve abscess Methods: Retrospective case report. RESULTS: A 72-year-old white male presented with fevers, encephalopathy, and decreased vision in his left eye. His visual acuity was 20/20 in his right eye and finger counting in the left eye. Workup revealed an aortic valve abscess. Examination of his left eye revealed dense anterior chamber fibrin and no view of the retina...
July 3, 2018: Ocular Immunology and Inflammation
Wantanee Sittivarakul, Prapaipim Wongkot
PURPOSE: To estimate the prevalence of positive anxiety and depression screening in patients with ocular inflammatory disease (OID). The predictors associated with anxiety and depressive symptoms were investigated. METHODS: A cross-sectional study was conducted. The Thai Hospital Anxiety and Depression Scale (HADS), a sociodemographic questionnaire, and the Thai Visual Functioning Questionnaire 28 were administered to all participants. Associations were estimated using the Cox regression...
July 3, 2018: Ocular Immunology and Inflammation
Ji Hun Song, Anjum F Koreishi, Debra A Goldstein
PURPOSE: To describe tuberculous uveitis (TU) presenting as a bullous retinal detachment (RD) and to perform a comprehensive literature review on TU with similar features. METHODS: Observational case report and systematic literature review. RESULTS: An 84-year-old woman presented with bilateral granulomatous uveitis and bullous RD in the left eye. The interferon gamma release assay was strongly positive, but all other tests were unremarkable...
July 3, 2018: Ocular Immunology and Inflammation
W Oliver Tobin, B Mark Keegan
No abstract text is available yet for this article.
June 29, 2018: Ocular Immunology and Inflammation
Manpreet Singh, Nalini Gupta, Zoramthara Zadeng, Nirbhai Singh, Manpreet Kaur, Pankaj Gupta
PURPOSE: To describe the clinico-radiological features and long-term outcomes in patients with tubercular dacryoadenitis (TbD) Methods: Retrospective, observational study of TbD patients who underwent a thorough clinical examination, orbital imaging study, and tailored ancillary investigations. Polymerase chain reaction (PCR) and microscopy were done in specific cases. A 4-drug anti-tubercular therapy (ATT) was started and clinical response was monitored in all. Patients with a minimum follow-up of 6 months "off-ATT" were included...
June 29, 2018: Ocular Immunology and Inflammation
Baek-Lok Oh, Jeong Seok Lee, Hee Young Lee, Hyeong Gon Yu
PURPOSE: To investigate the change in nationwide incidence of endophthalmitis following cataract surgery in Korea from 2002 to 2013. METHODS: From a national sample cohort (n = 1 025 340), cases of postoperative endophthalmitis between 2002 and 2013 were identified. RESULTS: From 70,719 cases of cataract surgery, 49 incidents of endophthalmitis were reported, yielding an incidence of 0.069% (95% confidence interval [CI], 0.051-0.092%). Overall, the endophthalmitis incidence decreased from 0...
June 28, 2018: Ocular Immunology and Inflammation
Ariel Schlaen, Daniel Colombero, Soledad Ormaechea, Emilio Ladeveze, Cesar Rudzinski, Mariana Ingolotti, Cristóbal Couto, Marcelo Rudzinski
PURPOSE: To compare the clinical characteristics of patients with active episodes of ocular toxoplasmosis from three provinces, Misiones, Santa Fe, and Buenos Aires, Argentina. METHODS: Patients with a diagnosis of ocular toxoplasmosis from three databases of four tertiary referral uveitis centers were reviewed. Collected data included presentation of the retinochoroiditis, location of the active lesions, associated inflammatory ocular signs and complications. RESULTS: Three hundred thirty-four patients were included in this study...
June 28, 2018: Ocular Immunology and Inflammation
Joshua Lane, Ethan Nyugen, Julie Morrison, Lyndell Lim, Richard Stawell, Lauren Hodgson, Muhammad Amir Bin Ismail, Ho Su Ling, Stephen Teoh, Rupesh Agrawal, Padmamalini Mahendradas, Parvathi Hari, Poornachandra B Gowda, Ankush Kawali, Peter J McCluskey
PURPOSE: To examine the spectrum of scleritis in four tertiary institutions across the Asia-Pacific. METHODS: Clinical records from 354 patients were reviewed from centers in Australia, Singapore, and India, excluding those with insufficient data (n = 24). RESULTS: Indian patients presented younger (41.5 ± 13.4 years) than Australians (50.8 ± 17.5) and Singaporeans (48.6 ± 15.9), with fewer women (49% vs 62%/57%). Diffuse disease was universally most common...
June 28, 2018: Ocular Immunology and Inflammation
Antonio Pinna, Tiziana Porcu, Giuseppe D'Amico-Ricci, Stefano Dore, Francesco Boscia, Panagiotis Paliogiannis, Ciriaco Carru, Angelo Zinellu
PURPOSE: To investigate the role of some blood count-derived inflammation biomarkers in age-related macular degeneration (AMD). METHODS: Seventy-nine men with late-stage AMD and 79 male age-matched cataract controls without AMD were recruited in March-December, 2016. A blood sample was taken. The following blood cell count-derived indexes were evaluated: neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells ‒ neutrophils)], platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), (neutrophils × monocytes)/lymphocyte ratio (SIRI), and (neutrophils × monocytes × platelets)/lymphocyte ratio (AISI)...
June 28, 2018: Ocular Immunology and Inflammation
Je-Hyung Hwang, Minji Ha, Yooyeon Park, So-Hyang Chung
PURPOSE: To report long-term outcomes of topical ganciclovir (GCV) and corticosteroids in Korean patients with cytomegalovirus (CMV) corneal endotheliitis. METHODS: This retrospective study included 13 eyes from 13 patients with CMV corneal endotheliitis, with a follow-up period of 24.5 ± 8.2 months. The patients were consistently maintained with topical 2% GCV and 1% prednisolone acetate eyedrop. RESULTS: All patients demonstrated unilateral typical coin-shaped keratic precipitates (KPs) or linear KP, and positive CMV polymerase chain reaction of aqueous humor...
June 28, 2018: Ocular Immunology and Inflammation
Arjun B Sood, Ghazala O'Keefe, Diem Bui, Nieraj Jain
PURPOSE: To report a case of Vogt-Koyanagi-Harada (VKH) disease associated with hepatitis B vaccination. METHODS: Case report. RESULTS: A 43-year-old Caucasian male presented with a three-week history of blurry vision, pain, photophobia, and redness in both eyes. Three days prior to the onset of symptoms, he had received the hepatitis B virus vaccine. Clinical evaluation revealed multifocal placoid lesions in the posterior pole, choroidal thickening, and serous macular detachment...
June 28, 2018: Ocular Immunology and Inflammation
Shilpa Kodati, Sapna Gangaputra, H Nida Sen
PURPOSE: To describe with multimodal imaging a case of post-infectious unilateral outer retinopathy with choroiditis. METHODS: Retrospective chart review of a case of a 67-year old male who presented following the onset of viral symptoms with an acute onset outer retinopathy, small vessel leakage on fluorescein angiography, and choroidal involvement evident on indocyanine green angiography and near infrared fundus autofluorescence (NIR-AF). Work up for infectious and autoimmune etiologies was negative...
June 28, 2018: Ocular Immunology and Inflammation
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