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Ocular Immunology and Inflammation

L M Hassman, M M Chung, M Gonzalez, A P Bessette
PURPOSE: To describe an uncommon presentation of ocular infection caused by human herpes simplex virus 2 (HSV-2). METHODS: Case report. RESULTS: A 32-year-old female with no prior history of mucocutaneous herpesvirus infection presented with a minimally painful hypertensive granulomatous panophthalmitis and optic neuropathy that was initially suspected to be orbital cellulitis. Her disease progressed despite antibiotic and steroid treatment, and HSV-2 was ultimately identified in the vitreous...
November 16, 2018: Ocular Immunology and Inflammation
Zoltan Griger, Katalin Danko, Levente Bodoki, Zsuzsa Aszalos, Gabor Nemeth, Hassan Ziad, Rudolf Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke
PURPOSE: To evaluate corneal parameters in patients with polymyositis (PM) and dermatomyositis (DM) and compare them with those of healthy controls. METHODS: A total of 43 PM and 32 DM patients and 93 controls were enrolled in this cross-sectional, observational, case-control study. Corneal parameters were evaluated by Pentacam. Objective clinical tests of dry eye disease (DED) were also performed. RESULTS: All pachymetric measurements and corneal volumes (CVs) proved to be significantly lower both in PM and DM patients...
November 16, 2018: Ocular Immunology and Inflammation
Andrew R Osborn, Sejoon Jun, Douglas C Miller, Bokkwan Jun
PURPOSE: To describe a case of p-ANCA associated vasculitis in a patient with bilateral vision loss with no systemic symptoms or signsMethods: A descriptive review of a caseResults: We report a case of bilateral sequential vision loss in a 73-year-old woman who had no constitutional symptoms except headache and was found to have positive p-ANCA and lymphocytic infiltration on bilateral temporal artery biopsy. Despite the early administration of systemic corticosteroids, the visual outcome was unfavorable...
November 14, 2018: Ocular Immunology and Inflammation
F Groen-Hakan, A A Van Der Eijk, A Rothova
PURPOSE: To determine characteristics of patients with laboratory findings indicative of intraocular Epstein-Barr-virus (EBV) infection and to establish the usefulness of the laboratory analysis in patients with uveitis. METHODS: Retrospective study of patients who underwent diagnostic aqueous fluid analysis. Diverse demographic data of patients were registered. RESULTS: EBV-PCR tested positive in 3/201 (1%) and EBV-GWC in 22/245 (9%). The prevalence of immunosuppression was similar in EBV positive (by PCR/GWC) and EBV negative patients (7/25; 28% vs...
November 13, 2018: Ocular Immunology and Inflammation
Anna-Maria Haas, Martin Stattin, Daniel Ahmed, Ilse Krebs, Siamak Ansari-Shahrezaei
PURPOSE: To elaborate a case of focal choroidal excavation (FCE) in punctate inner choroidopathy (PIC) complicated by secondary choroidal neovascularization (CNV) based on multimodal imaging findings. METHODS: In this retrospective case report, multimodal imaging including near-infrared reflectance, blue peak autofluorescence, spectral domain-optical coherence tomography (OCT), fluorescein and indocyanine green angiography (Heidelberg Engineering GmbH, Germany), and swept source-OCT angiography (SS-OCTA; Topcon Corporation, Japan) was performed...
November 13, 2018: Ocular Immunology and Inflammation
Enver Mirza, Refik Oltulu, Zeynep Katipoğlu, Günsu Deniz Mirza, Ahmet Özkağnıcı
PURPOSE: To evaluate the association between monocyte count/high-density lipoprotein (HDL) ratio (MHR) and lymphocyte count/monocyte count ratio (LMR) with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG). MATERIALS AND METHODS: A total of 63 participants included in the study. Participants were divided into three groups. Twenty-one patients with PEXS regarded as group 1, 21 patients with PEXG regarded as group 2 and 21 participants without PEXS or PEXG regarded as the control group...
November 13, 2018: Ocular Immunology and Inflammation
Eiman Abd El Latif, Mouamen M Seleet, Hazem El Hennawi, Mohamed Abdulbadiea Rashed, Hossameldeen Elbarbary, Karim Sabry, Mohamed Abdelmonagy Ibrahim
PURPOSE: To report the clinical experience with scleritis at four Egyptian tertiary care eye centers. METHODS: Multicenter retrospective chart review of all patients with scleritis visiting four ocular inflammation referral clinics in Egypt between January 2013 and October 2017. RESULTS: A total of 303 scleritis patients were enrolled. These included 76 male and 227 female patients. The most frequent subtype of scleritis was nodular anterior scleritis (44...
November 9, 2018: Ocular Immunology and Inflammation
Simar Rajan Singh, Mohit Dogra, Savleen Kaur, Priya Bajgai, Basavaraj Tigari, Sabia Handa, Deeksha Katoch, Vishali Gupta, Mangat R Dogra, Aman Sharma, Ramandeep Singh
PURPOSE: To characterize the presenting features of cytomegalovirus (CMV) retinitis in HIV-positive patients in a developing country in the HAART era. METHODS: Retrospective chart review of all patients with CMV retinitis seen at a tertiary-care referral center between January 2006 to June 2017. Demographic and clinical data were collected to study the presenting features and risk factors for blindness. RESULTS: Fifty-five patients with treatment-naïve CMV retinitis were enrolled; 75% were males...
November 5, 2018: Ocular Immunology and Inflammation
Julien Rohmer, Jérôme Hadjadj, Amina Bouzerara, Sawsen Salah, Romain Paule, Matthieu Groh, Philippe Blanche, Luc Mouthon, Dominique Monnet, Claire Le Jeunne, Jean Guibourdenche, Antoine Brézin, Benjamin Terrier
PURPOSE: The diagnostic workup of uveitis is challenging, with 30 to 50% of cases remaining of undetermined etiology despite multiple investigations. Sarcoid granuloma-related increase of 1,25(OH)2 D levels could be helpful for the diagnosis of ocular sarcoidosis. METHODS: Monocentric retrospective cohort study of patients for whom serum 25(OH)D and 1,25(OH)2 D levels were measured during the etiologic workup of unexplained uveitis in a tertiary referral center...
November 5, 2018: Ocular Immunology and Inflammation
Tomoko Ohno, Akira Meguro, Masaki Takeuchi, Takahiro Yamane, Takeshi Teshigawara, Nobuyoshi Kitaichi, Yukihiro Horie, Kenichi Namba, Shigeaki Ohno, Kumiko Nakao, Taiji Sakamoto, Tsutomu Sakai, Tadashi Nakano, Hiroshi Keino, Annabelle A Okada, Atsunobu Takeda, Takako Fukuhara, Hisashi Mashimo, Nobuyuki Ohguro, Shinichirou Oono, Hiroshi Enaida, Satoshi Okinami, Nobuhisa Mizuki
PURPOSE: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. METHODS: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9. We also performed imputation analysis of the ARMC9 region and 195 imputed SNPs were included in the statistical analysis. RESULTS: We observed an increased frequency of the A allele of rs28690417 in patients compared with controls (P = 0...
November 5, 2018: Ocular Immunology and Inflammation
Victor Llorenç, Gibet Benejam, Marina Mesquida, Maite Sainz de la Maza, Blanca Molins, Carmen Alba, Laura Pelegrin, Jose Antonio Martínez, Alfredo Adán
PURPOSE: To study the risk factors for visual loss in presumed tuberculosis-related uveitis (TRU). METHODS: Retrospective observational cohort study of patients with TRU, either treated or not for tuberculosis, from January 2005 to January 2017. Clinical and demographic variables were recorded. Main outcome measure was a loss of visual acuity (VA) of ≥2 Snellen lines. A Generalized Estimation Equation was used to control between-eyes bias. A backward stepwise logistic regression multivariate analysis was conducted to elucidate independent risk factors...
November 5, 2018: Ocular Immunology and Inflammation
Yu-Qin Wang, Xiao-Dan Dai, Yun Ran, Ying Cao, Chun-Lin Lan, Ji-Tian Guan, Chang Liu, Feng-Mei Yang, Yi-Jing Gan, Bai-Jing Liu, Ai-Wu Fang, Dan Lin, Xian-Hui Gong, Ren-Zhe Cui, Zi-Bing Jin, Jia Qu, Fan Lu, Zai-Long Chi
PURPOSE: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. METHODS: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. RESULTS: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0...
November 5, 2018: Ocular Immunology and Inflammation
Wietse G Wieringa, Wineke Armbrust, G Elizabeth Legger, Leonoor I Los
PURPOSE: To analyze the efficacy of high dose (≥ 15mg/m2/week) methotrexate (MTX) versus low dose (<15mg/m2/week) MTX in relation to time to remission on medication. METHODS: Retrospective observational cohort study of pediatric patients with auto-immune uveitis with or without underlying systemic disease treated with MTX at the University Medical Center Groningen (the Netherlands) between 1990 and 2014. Primary outcome was time to remission on medication, which was defined as an observable inactive disease in the affected eye for longer than 3 months without the use of systemic corticosteroids...
October 22, 2018: Ocular Immunology and Inflammation
Kowsigan Magesan, Parthopratim Dutta Majumder
PURPOSE: To describe a case of choroidal tubercle in a patient with Eales disease after 6 years, whose initial work-ups were negative for systemic diseases. METHODS: A retrospective chart review Results: This case report describes a 39-year-old male with a 6-year history of Eales disease characterized by recurrent inflammations and vitreous hemorrhages in his both eyes. His systemic work-up at the initial presentation was normal which included a negative Mantoux test and a normal chest X-ray...
October 19, 2018: Ocular Immunology and Inflammation
Elizabeth Shen, Kate Xie, Kevin Jwo, Janellen Smith, Sameh Mosaed
No abstract text is available yet for this article.
October 18, 2018: Ocular Immunology and Inflammation
Rebecca Low, Elizabeth J Chen, Muhammad Amir Bin Ismail, Helen Mi, Ho Su Ling, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal
PURPOSE: To analyze the pattern of laboratory investigations of uveitis at a tertiary referral eye care center in Singapore. METHODS: Retrospective analysis of 2040 uveitis cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database over a 12-year period (2004 - 2015). RESULTS: Patients with retinal vasculitis (RV) had the most tests utilized per patient (6.79), followed by intermediate uveitis (IU) (5.25), panuveitis (Pan) (5...
October 18, 2018: Ocular Immunology and Inflammation
Satoru Kase, Kenichi Namba, Hiromi Kanno-Okada, Masahiro Onozawa, Daisuke Hidaka, Daiju Iwata, Kazuomi Mizuuchi, Takako Fukuhara, Junichi Fukuhara, Nobuyoshi Kitaichi, Yoshihiro Matsuno, Susumu Ishida
PURPOSE: The aim of this study was to analyze immunohistochemical and immunocytological findings by examining enucleated eyes and vitreous cell block (CB) in patients with vitreoretinal lymphoma (VRL). METHODS: Histological specimens were obtained from two enucleated eyes with VRL associated with neovascular glaucoma. CB specimens were prepared in 18 patients from diluted waste fluids containing shredded vitreous. Histological and cytological specimens were submitted for hematoxylin-eosin staining and immunopathological analyses...
October 18, 2018: Ocular Immunology and Inflammation
Zohar Habot-Wilner, Liran Tiosano, Juan M Sanchez, Shiri Shulman, Dana Barequet, Ori Rahat, Gil Amarilyo, Radgonde Amer
PURPOSE: To report the epidemiology, etiology, ocular characteristics, treatment and visual outcome of pediatric uveitis in Israel. METHODS: Retrospective study from two tertiary uveitis centers. RESULTS: Included were 107 patients (182 eyes), 55% females. Mean age at diagnosis 8.8 years. Uveitis was predominantly anterior, idiopathic, bilateral, and chronic. Systemic associations were seen in 36% of patients of which the most common disease was juvenile idiopathic arthritis...
October 17, 2018: Ocular Immunology and Inflammation
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2018: Ocular Immunology and Inflammation
Ron Neumann, Dana Barequet, Amir Rosenblatt, Radgonde Amer, Yael Ben-Arie-Weintrob, Tamar Hareuveni-Blum, Vicktoria Vishnevskia-Dai, Eyal Raskin, Oren Blumenfeld, Shiri Shulman, Juan M Sanchez, Victor Flores, Zohar Habot-Wilner
PURPOSE: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy. METHODS: Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR). RESULTS: The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis...
October 12, 2018: Ocular Immunology and Inflammation
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