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Ocular Immunology and Inflammation

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https://www.readbyqxmd.com/read/29120678/patterns-of-uveitis-at-two-university-based-referral-centres-in-cape-town-south-africa
#1
Wilna Rautenbach, Jonel Steffen, Derrick Smit, Karin Lecuona, Tonya Esterhuizen
PURPOSE: To analyze the pattern of uveitis at two tertiary hospitals in South Africa which has a high prevalence of HIV, TB and syphilis. METHODS: Data of 198 patients were obtained retrospectively between August 2014 and August 2016, including patient demographics, clinical examination, special investigations and final diagnosis. RESULTS: Infectious uveitis was the most common aetiological category (47%), followed by idiopathic (34.8%) and non-infectious (18...
November 9, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29099660/ten-year-retention-rate-of-infliximab-in-patients-with-beh%C3%A3-et-s-disease-related-uveitis
#2
Claudia Fabiani, Jurgen Sota, Antonio Vitale, Giacomo Emmi, Lorenzo Vannozzi, Daniela Bacherini, Giuseppe Lopalco, Silvana Guerriero, Vincenzo Venerito, Ida Orlando, Rossella Franceschini, Fiorella Fusco, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
PURPOSE: To evaluate the 10-year drug retention rate of infliximab (IFX) in Behçet's disease (BD)-related uveitis, the effect of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on drug survival and differences according to the lines of biologic treatment. METHODS: Cumulative survival rates were studied using the Kaplan-Meier plot, while the Log-rank (Mantel-Cox) test was used to compare survival curves. RESULTS: Forty patients (70 eyes) were eligible for analysis...
November 3, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29099641/intraocular-lymphoma-masquerading-as-recurrent-iridocyclitis-findings-based-on-in-vivo-confocal-microscopy
#3
Pu Zhang, Jiao Tian, Ling Gao
PURPOSE: To emphasize the application prospects of in vivo confocal microscopy (IVCM) in distinguishing intraocular lesions from inflammatory and neoplastic diseases. METHODS: Retrospective case report. RESULTS: A patient with neoplastic masquerade syndrome initially underwent IVCM examination. After six separate intravitreal injections of 400 mg/0.1 ml methotrexate, IVCM revealed a complete remission of intraocular lymphoma. CONCLUSIONS: Although IVCM findings alone are not enough to diagnose intraocular neoplasm with absolute certainty, they can provide useful indication for distinguishing between intraocular inflammatory diseases and neoplasms...
November 3, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29099638/type-1-boston-keratoprosthesis-for-limbal-stem-cell-deficiency-in-epidermolysis-bullosa
#4
N Geetha Sravani, Ashik Mohamed, Virender S Sangwan
No abstract text is available yet for this article.
November 3, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29095066/detecting-change-in-conjunctival-hyperemia-using-a-pixel-densitometry-index
#5
Vito Romano, Bernhard Steger, Matthias Brunner, Abigail Kaye, Yalin Zheng, Colin E Willoughby, Stephen B Kaye
PURPOSE: To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI). METHODS: Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5%. RESULTS: A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17...
November 2, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29095065/anterior-scleritis-associated-with-pemphigus-vulgaris
#6
Tal Zeeli, Efrat Bar-Ilan, Zohar Habot-Wilner, Eli Sprecher
We present a rare co-occurrence of anterior scleritis developing in a patient with recalcitrant pemphigus vulgaris. We discuss the clinical and therapeutic implications of these two conditions and offer concise recommendations.
November 2, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29072860/clinical-profile-of-herpes-zoster-ophthalmicus-in-a-south-indian-patient-population
#7
Kalpana Babu, Padmamalini Mahendradas, Bhagya Sudheer, Ankush Kawali, Deepika C Parameswarappa, Vibha Pal, Mariamma Philips
PURPOSE: To analyze and compare the clinical profile of herpes zoster ophthalmicus (HZO) patients in a South Indian patient population aged <60 years and ≥60 years and determine the risk factors for recurrence of ocular inflammation. METHODS: Retrospective study of 249 cases between 2006 and 2016 from two tertiary referral eye centres in south india. RESULTS: Out of 249 cases, 189 cases were <60 years (Group 1) and 60 cases were aged ≥60 years (Group2)...
October 26, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29053397/combined-intravitreal-and-systemic-antibiotic-therapy-in-a-patient-with-syphilitic-uveitis
#8
Arjun B Sood, William A Pearce, Kimberly A Workowski, James Lockwood, Steven Yeh
PURPOSE: To report the novel use of combined intravitreal and systemic antibiotic therapy in a patient with syphilitic panuveitis and discuss the management of ocular syphilis. METHODS: Case report Results: A 45-year old heterosexual male with human immunodeficiency virus (HIV) presented with 1 month of blurry vision in both eyes. Clinical examination revealed a bilateral panuveitis. The patient denied history of genital lesions or rash, but did complain of difficulty hearing bilaterally...
October 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29043914/authors-reply-to-letter-to-the-editor-in-response-to-comment-on-durrani-et-al-s-adalimumab-for-ocular-inflammation
#9
Khayyam Durrani, John H Kempen, C Stephen Foster
No abstract text is available yet for this article.
October 18, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040051/two-novel-capn5-variants-associated-with-mild-and-severe-autosomal-dominant-neovascular-inflammatory-vitreoretinopathy-phenotypes
#10
Nadia M Randazzo, Morag E Shanks, Penny Clouston, Robert E MacLaren
PURPOSE: We report two new CAPN5 mutations associated with a phenotype of Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy. METHODS: We performed next generation sequencing in two patients with ADNIV phenotype; the variants identified were explored further. RESULTS: Patient 1 was heterozygous for CAPN5 c.799G>A, p.(Gly267Ser). Patient 2 was heterozygous for CAPN5 c.1126G>A, p.(Gly376Ser). Both amino acids are highly conserved across species...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040047/ultra-widefield-fluorescein-angiography-in-intermediate-uveitis
#11
Wipada Laovirojjanakul, Nisha Acharya, John A Gonzales
PURPOSE: To examine associations between pattern of vascular leakage on ultrawide-field fluorescein angiography (UWFFA) and visual acuity, cystoid macular edema (CME), and inflammatory activity in intermediate uveitis. METHODS: Single center cross-sectional, retrospective review of medical records, spectral domain optical coherence tomography (SD-OCT) and angiographic images of intermediate uveitis patients who underwent UWFFA over a 12-month period. RESULTS: Forty-one eyes from 24 patients were included...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040035/long-term-efficacy-and-safety-of-interferon-alpha-2a-in-the-treatment-of-chinese-patients-with-beh%C3%A3-et-s-uveitis-not-responding-to-conventional-therapy
#12
Peizeng Yang, Guo Huang, Liping Du, Zi Ye, Ke Hu, Chaokui Wang, Jian Qi, Liang Liang, Lili Wu, Qingfeng Cao, Aize Kijlstra
PURPOSE: To investigate the long-term efficacy and safety of interferon alpha-2a (IFNα-2a) in Chinese patients with Behçet's uveitis (BU) refractory to conventional therapy. METHODS: In a prospective observational cohort study, 127 patients were treated with an initial dosage of 3 million units per day in the first three months, followed by gradual tapering of the dose. RESULTS: After 3 months of treatment, IFNα-2a was shown to be effective in 115 cases (91%)...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040032/interventions-and-outcomes-in-patients-with-infectious-pseudomonas-scleritis-a-10-year-perspective
#13
Sumayya Ahmad, Michelle Lopez, Marwan Attala, Anat Galor, Natalie A Stanciu, Darlene Miller, Leejee Suh, Thomas Albini, Victor L Perez, Carol L Karp, Janet L Davis, Eduardo Alfonso, Richard K Forster, Guillermo Amescua
PURPOSE: To identify interventional factors associated with improved visual results and faster time to resolution for patients with Pseudomonas scleritis. METHODS: Retrospective study analyzing inciting factors, therapeutic modalities, and outcomes of patients with Pseudomonas scleritis. RESULTS: A total of 24 patients were analyzed; 22 were treated as outpatients. All had resolution of infection and 58% (n = 14) maintained ≥20/200 vision...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040009/ocular-involvement-in-patients-with-fungemia-in-an-urban-tertiary-care-center
#14
Kenneth W Price, Edmund Tsui, Irene Barbazetto, Lisa Park
PURPOSE: To illustrate the rate of endogenous endophthalmitis associated with fungemia and evaluate the importance of screening in a public city hospital. METHODS: A retrospective review was performed on all inpatient ophthalmology consults for fungemia from 2010 to 2015. Clinical histories, ocular examinations, and microbial cultures were reviewed. RESULTS: Of 95 patients (mean age 51.6 years, 75% male) with fungemia, 9/95 (9.5%) demonstrated intraocular involvement...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040008/analysis-of-the-clinical-profile-and-management-of-inflammatory-choriodal-neovascular-membranes-in-uveitic-eyes-a-study-from-a-tertiary-referral-center
#15
Sudha Ganesh, Arshee Ahmed, Jyotirmay Biswas
PURPOSE: To analyze clinical profile and management of inflammatory choroidal neovascularization (CNV) seen at a referral uveitis clinic. METHODS: Records of patients with uveitis and inflammatory CNV from January 1989 to April 2012 were retrieved and the data was analyzed. RESULTS: Forty-nine eyes of 43 patients were included. Mean age at presentation was 35.81 years. Eighteen eyes (36.7%) had infective etiology and 31 eyes (63.2%) had non-infective etiology...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29039992/polymerase-chain-reaction-and-goldmann-witmer-coefficient-to-examine-the-role-of-epstein-barr-virus-in-uveitis
#16
Derrick Smit, David Meyer, Jean Maritz, Jolanda D F de Groot-Mijnes
PURPOSE: To use polymerase chain reaction (PCR) and Goldmann-Witmer Coefficient (GWC) calculation to search for evidence that Epstein-Barr virus (EBV) causes uveitis. METHODS: A prospective cross-sectional study where participants with positive multiplex EBV PCR results were further investigated by: 1) real-time PCR for EBV viral loads (VL) and 2) EBV GWC. RESULTS: Eleven of 106 consecutive uveitis patients (10.4%) had positive multiplex PCR for EBV on aqueous humor sampling and 7/11 (63...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29039981/calcitriol-the-active-metabolite-of-vitamin-d3-inhibits-dry-eye-related-corneal-inflammation-in-vivo-and-in-vitro
#17
Jing Zhang, Yiqin Dai, Dan Wu, Jianjiang Xu
PURPOSE: To examine the influence of topical administration of calcitriol on dry eye (DE) related corneal inflammation. METHODS: Benzalkonium chloride (BAC, 0.2%) was applied to induce DE. Then rats were treated topically with calcitriol (10(-6)μM). Tear break-up time (TBUT), fluorescein staining score, inflammatory index, and tear volume were measured. Corneal epithelium damage and corneal inflammation were examined by H&E staining or RT-qPCR. In vitro, human corneal epithelial cells (iHCEC) were cultured in hyperosmotic medium (450 mOsM) with various concentrations of calcitriol...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29035614/the-impact-and-implication-of-peripheral-vascular-leakage-on-ultra-widefield-fluorescein-angiography-in-uveitis
#18
Akshay S Thomas, Travis Redd, John P Campbell, Neal V Palejwala, Justin T Baynham, Eric B Suhler, James T Rosenbaum, Phoebe Lin
PURPOSE: To study if peripheral vascular leakage (PVL) on ultra-widefield fluorescein angiography (UWFFA) prognosticates complications of uveitis or necessitates treatment augmentation. METHODS: Retrospective cohort study of uveitis patients imaged with UWFFA and ≥1 yr of follow-up. RESULTS: We included 73 eyes of 42 patients with uveitis. There was no difference in baseline, intermediate, final visual acuity (p = 0.47-0.95) or rates of cystoid macular edema (CME) (p = 0...
October 16, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29035612/enhanced-vitreous-imaging-in-uveitis
#19
Padmamalini Mahendradas, Sumukh Madhu, Ankush Kawali, Abhijit Sinha Roy, Ruchi Vala, Anand Vinekar, Rohit Shetty
PURPOSE: To study the structural visibility of the posterior vitreous cavity and vitreoretinal interface using Spectral Domain-Optical Coherence Tomography in patients with uveitis using conventional, Enhanced Depth Imaging (EDI), Combined Depth Imaging (CDI), and Enhanced Vitreous Imaging (EVI) techniques. METHODS: It was an observational cross-sectional study of 59 eyes of 33 patients between age group 12-72 years (Median 43) diagnosed as uveitis with posterior segment manifestations underwent OCT using conventional, EDI, CDI, and EVI techniques...
October 16, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29028422/enterococcus-faecalis-endophthalmitis-in-children-a-21-year-study
#20
Ekta Rishi, Pukhraj Rishi, Pramod Bhende, Rajiv Raman, Parveen Sen, Pradeep Susvar, Chetan Rao, Lily Therese, Rajshri Hirawat
PURPOSE: To report Enterococcus faecalis endophthalmitis (EFE) in children and its comparison with adults. METHODS: Retrospective study of 19 children up to 18 years age, undergoing vitrectomy for EFE at a referral eye center from January 1995 to December 2015. The results were compared to 18 adults with EFE. RESULTS: The mean age was 7.4 ± 3.06 years. Post-traumatic EFE was seen in 17 (89.4%) children (p < 0.05) versus postoperative EFE seen in 12 (66%) adults...
October 13, 2017: Ocular Immunology and Inflammation
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