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Ocular Immunology and Inflammation

Milad Modabber, Mona Harissi-Dagher
No abstract text is available yet for this article.
March 15, 2018: Ocular Immunology and Inflammation
Madan Upadhyay, Ranju Kharel Sitaula, Bharat Shrestha, Bhaiya Khanal, Bishnu Psd Upadhyay, Jeevan B Sherchand, Prakash Ghimire
PURPOSE: This review aims to provide a detailed update in Seasonal hypercute panuveitis (SHAPU) which is a blinding disease of unknown etiology reported only from Nepal, occurring every odd year since 1975 predominantly in children. METHODS: Data sources were literature reviewed using PubMed, Medline, and ISI Databases (since 1975 to late 2017). Search items included SHAPU, seasonal endophthalmitis, hypopyon uveitis, caterpillar induced uveitis alone or in combination with white moth, panuveitis, and review...
March 15, 2018: Ocular Immunology and Inflammation
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
March 15, 2018: Ocular Immunology and Inflammation
Bhagya Sudheer, Manisha Agarwal, Deepa Sharma, Ravi Mehta, Kalpana Babu
PURPOSE: To report our experience of using Endobronchial ultrasound-guided transbronchial lymph node aspiration (EBUS-TBNA) in assessing the etiology in uveitis from two tertiary eye-care centers in India. MATERIALS & METHODS: Retrospective interventional case series. RESULTS: A total of 99 patients of uveitis who underwent EBUS-TBNA were included in the study. Mycobacterium tuberculosis (MTb) was detected on culture in 5 cases, 3 cases by polymerase chain reaction and caseating granulomas in 25 cases...
March 15, 2018: Ocular Immunology and Inflammation
Hiroshi Nakatani, Paul Gomes, Ron Bradford, Qiang Guo, Eleonora Safyan, David A Hollander
PURPOSE: To compare alcaftadine and olopatadine ophthalmic solutions, and vehicle for preventing allergen-mediated conjunctivitis in Japanese subjects. METHODS: Japanese cedar pollen-sensitive subjects were randomized to alcaftadine 0.25%, olopatadine 0.1%, or vehicle. Ocular itching was assessed at 3, 5 (primary outcome), 7, and 15 min post-conjunctival allergen challenge (CAC) and conjunctival hyperemia assessed at 7, 15 (secondary outcome), and 20 min post-CAC...
March 15, 2018: Ocular Immunology and Inflammation
Nicholas P Jones, Archana Pradeep, Binu John
PURPOSE: To identify the causes of severe visual loss in a UK uveitis clinic, to suggest means of reducing incidence, and to propose improvement in data collection of vision impairment. PATIENTS AND METHODS: Retrospective case series. RESULTS: Over 128 months, 76 (3.5-4% of patients referred) were certified as vision-impaired or severely vision-impaired. The mean age at registration was 48.4 years, 76% were of working age, and 7% were children...
March 15, 2018: Ocular Immunology and Inflammation
Jolanda D F De Groot-Mijnes, Anita S Y Chan, Soon-Phaik Chee, Georges M G M Verjans
Herpes simplex virus, varicella zoster virus, human cytomegalovirus, and rubella virus are the most common causes of virus-induced anterior uveitis. They can present in a variety of entities not only with typical but also overlapping clinical characteristics. These viral infections are commonly associated with ocular infiltration of T cells and B/plasma cells, and expression of cytokines and chemokines typical of a proinflammatory immune response. The infections differ in that the herpes viruses cause an acute lytic infection and inflammation, whereas rubella virus is a chronic low-grade infection with slowly progressing immunopathological responses...
March 15, 2018: Ocular Immunology and Inflammation
Dilay Ozek, Özlem Evren Kemer, Ferda Artüz
PURPOSE: To evaluate the results of tear functions in acne rosacea. METHODS: This prospective study includes 64 eyes of 32 acne rosacea patients without blepharitis and meibomian gland dysfunction and 90 eyes of 45 patients as control group. Tear functions of all were evaluated with ocular surface disease index (OSDI) questionnaire, and measurements of tear osmolarity were performed by using TearLab, Schirmer I tests without anesthesia and fluorescein tear break-up time (TBUT)...
March 13, 2018: Ocular Immunology and Inflammation
Lina Ma, Caiyun You, Mikhail Hernandez, Arash Maleki, Andres Lasave, Alexander Schmidt, Andrew Stephenson, Thongzen Zhao, Stephen Anesi, C Stephen Foster
PURPOSE: To assess the long-term efficacy and safety of IVIg monotherapy in patients with recalcitrant ocular cicatricial pemphigoid (OCP). METHODS: A chart review of all OCP patients seen at the Massachusetts Eye Research and Surgery Institution (MERSI) between 2005 and 2015 was completed. Stage was graded by using the Foster grading system. IVIg infusion was 2g/kg/cycle administered in 3 consecutive days monthly. RESULTS: Of 512 OCP patients, 17 patients (34 eyes) treated with IVIg monotherapy were identified...
March 8, 2018: Ocular Immunology and Inflammation
Sung Who Park, So Hee Kim, Han Jo Kwon, Seung Min Lee, Ik Soo Byon, Ji Eun Lee
PURPOSE: To assess the value of positive immunoglobulin (Ig) M serum antibody (Ab) findings in uveitis patients. METHODS: We reviewed medical records of patients who had a positive serological test for Toxoplasma gondii-specific IgM Ab. Their clinical data, including history, demographic characteristics, laboratory findings, clinical findings, treatment outcomes, and recurrences, were reviewed retrospectively. RESULTS: Of 2919 uveitis patients who underwent a serological test for suspected ocular toxoplasmosis (OT), 18 presented with positive Ig M results...
March 7, 2018: Ocular Immunology and Inflammation
Sana Khochtali, Imen Ksiaa, Kenza Megzari, Moncef Khairallah
PURPOSE: To report the cases of two patients who presented with acute Vogt-Koyanagi-Harada (VKH) disease and associated retinal pigment epithelium detachment (PED). METHODS: 2 case reports. Case 1: A 22-year-old male patient complained of acute bilateral decrease in vision. Initial best corrected visual acuity (BCVA) was 20/63, OU. There was 1+ vitreous cells, OU, exudative retinal detachment (ERD) in the right eye (RE), and a macular deep yellow lesion suggestive of PED in the left eye (LE)...
March 7, 2018: Ocular Immunology and Inflammation
Jianping Hu, Yirong Qin, Shenglan Yi, Chaokui Wang, Jinglu Yang, Lu Yang, Luoziyi Wang, Aize Kijlstra, Peizeng Yang, Hong Li
PURPOSE: Recent studies have reported that IL-35 has a protective effect in autoimmune disease. In this study, we explored the role of IL-35 in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. METHODS: The IL-35/EBI3 and IL-35/P35 mRNA level was assayed by Real-Time PCR. The level of IL-35 in serum was detected by ELISA. PBMCs and monocyte-derived DCs were cultured with or without IL-35 and the concentration of IL-17, IL-10, IFN-γ, IL-6, TNF-α, and IL-1β in supernatants was tested by ELISA...
March 2, 2018: Ocular Immunology and Inflammation
Alexandra Martín Ramírez, Laura Cardeñoso Domingo, J Jacobo González Guijarro
PURPOSE: Describing the utility of Polymerase Chain Reaction for Cytomegalovirus (CMV-PCR) in the diagnosis of suspected viral anterior uveitis (AU). PATIENTS AND METHODS: We analyzed aqueous humor (AH) CMV-PCR positivity and treatment modifications in 47 eyes of 46 patients with viral uveitis and its correlation with high intraocular pressure (HIOP), uveitis clinical characteristics and time intervals from samples to uveitis diagnosis and to relapse. RESULTS: CMV-PCR positive results occurred in 13 eyes (27...
February 23, 2018: Ocular Immunology and Inflammation
Gulten Sungur, Mehmet Yakin, Selma Uzman, Ozgur Balta, Gozde Orman, Firdevs Ornek
PURPOSE: To investigate clinical features, visual prognosis, and ocular complications in patients with ankylosing spondylitis (AS)-associated anterior uveitis (AU). METHODS: Data of 211 eyes of 145 patients with AU associated with AS were reviewed retrospectively. RESULTS: Mean follow-up time was 6.31 ± 6.33 years. Men were younger than women at AS diagnosis (p = 0.035). The mean number of uveitis flares was highest during the first quarter of the year and lowest during the third quarter (p = 0...
February 23, 2018: Ocular Immunology and Inflammation
Stephanie M Llop, Samaneh Davoudi, Lynn K Stanwyck, Shaleen Sathe, Lisa Tom, Tina Ahmadi, Lindsay Grotting, George N Papaliodis, Lucia Sobrin
PURPOSE: To determine whether an association between Vitamin D and noninfectious ocular inflammation exists. METHODS: Retrospective case-control study with 765 patients (333 uveitis cases, 103 scleritis cases, 329 controls). Logistic regression models examined the relationship between hypovitaminosis D and ocular inflammation. RESULTS: The odds of having uveitis were 1.92 times higher for patients with hypovitaminosis D compared to patients with normal Vitamin D levels in the multivariate analysis [odds ratio (OR) = 1...
February 23, 2018: Ocular Immunology and Inflammation
Rupesh Agrawal, Sai Bo Bo Tun, Praveen Kumar Balne, Hong-Yuan Zhu, Neha Khandelwal, Veluchamy A Barathi
PURPOSE: To study the effect of anti-VEGF treatment on retinal inflammation in a laser-induced CNV rodent model. METHODS: Leukocytes labeled with 1% sodium fluorescein were injected into the laser-induced CNV (wild type C57BL/6) mice at days 4 (baseline), 7, 14, and 19. At baseline intravitreally 3 mice received 1× PBS, and 3 mice received anti-VEGF. FFA, OCT, and SLO were performed at each time point to assess the CNV pathophysiology and inflammatory response...
February 22, 2018: Ocular Immunology and Inflammation
Harpal Singh Sandhu, Amir Hajrasouliha, Henry J Kaplan, Wei Wang
PURPOSE: To compare genetic testing for microbes in infectious endophthalmitis or uveitis to culture. METHODS: This was a retrospective, single-center case series that enrolled patients with clinically suspected endophthalmitis or uveitis of unknown etiology. Aqueous humor or vitreous was collected and sent for routine cultures and genetic testing. RESULTS: In total, 46 patients were enrolled. Genetic testing was positive in 32/46 (70%) cases and culture 6/46 cases (13%)...
February 22, 2018: Ocular Immunology and Inflammation
Alessandro Invernizzi, Franca Iannaccone, Sylvia Marchi, Valentina Mastrofilippo, Marco Coassin, Luigi Fontana, Carlo Salvarani, Peter McCluskey, Luca Cimino
PURPOSE: To assess the efficacy and tolerability of interferon (IFN) alpha-2a in post-infectious uveitis secondary to presumed intraocular tuberculosis (IOTB). METHODS: Patients with chronic uveitis secondary to presumed IOTB who, after completing an antitubercular treatment, showed poor response to treatments or recurred after tapering oral corticosteroids to ≤7.5 mg/day were enrolled. All patients were treated with IFN alpha-2a subcutaneous injections. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and inflammatory signs were compared between baseline and follow-up visits up to six months...
February 22, 2018: Ocular Immunology and Inflammation
Nisha R Acharya, Sarju Patel, Gelareh Homayounfar, Wayne T A Enanoria, Akbar Shakoor, Anindita Chakrabarti, Debra A Goldstein
PURPOSE: To assess treatment outcomes in juvenile idiopathic arthritis (JIA)-associated uveitis and relapse rates upon discontinuation of immunomodulatory therapy (IMT). METHODS: Medical records of patients with JIA-associated uveitis seen at the University of Illinois at Chicago and the F.I. Proctor Foundation uveitis clinics from September 14, 1988 to January 5, 2011 were reviewed. The main outcome was time to relapse after attempting to discontinue IMT. RESULTS: Of 66 patients with JIA-associated uveitis, 51 (77%) received IMT as either sole or combination therapy...
February 16, 2018: Ocular Immunology and Inflammation
Chitaranjan Mishra, Prajna Lalitha, Gunasekaran Rameshkumar, Rupesh Agrawal, Praveen Kumar Balne, Mani Iswarya, Naresh Babu Kannan, Kim Ramasamy
PURPOSE: To report the incidence and characteristics of endophthalmitis after intravitreal injections (IVI) of antivascular endothelial growth factor agents and triamcinolone acetonide. METHODS: Patients' medical records were retrospectively reviewed from January 2009 to June 2016, and the incidence, risk factors, clinical and microbiological characteristics of post-IVI endophthalmitis were evaluated. RESULTS: The total number of intravitreal injections given, which included ranibizumab, bevacizumab, and triamcinolone acetonide, was 20,566, of which 27 cases developed endophthalmitis, giving an overall incidence of 0...
February 13, 2018: Ocular Immunology and Inflammation
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