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Journal of Heart Valve Disease

Neil Ruparelia, Azeem Latib, Eustachio Agricola, Fabrizio Monaco, Pietro Spagnolo, Ottavio Alfieri, Matteo Montorfano, Antonio Colombo
Today, increasing numbers of patients are presenting to clinical teams with signs and symptoms of mitral bioprosthesis failure. Whilst redo surgery is currently the treatment option of choice, many patients have multiple co-morbidities and are deemed to be of prohibitively high surgical and anaesthetic risk. Percutaneous transcatheter treatment can offer a potential solution for these patients. Herein is reported a case where simultaneous transcatheter interventions for paraprosthetic leak and mitral bioprosthesis implantation were performed via the transfemoral route, and an unforeseen complication was successfully managed...
September 2015: Journal of Heart Valve Disease
Amy Adkins, Jesus Aleman, Lori Boies, Edward Sako, Shamik Bhattacharya
BACKGROUND AND AIM OF THE STUDY: Tricuspid annuloplasty is the most preferred technique for the treatment of functional tricuspid regurgitation (FTR). However, high incidences of recurrent regurgitation and risky reoperation demands a deeper insight into the technique. The cinching force required to bring a dilated annulus back to the original size is unknown. The study aim was to quantify the cinching force in the tricuspid annulus which can contribute to the long-term durability of tricuspid annuloplasty and percutaneous device design...
September 2015: Journal of Heart Valve Disease
Sami M Alnasser, Osama Benhomeid, Mark D Peterson, Christopher E Buller, David Latter, Djeven P Deva, Asim N Cheema
Transcatheter aortic valve replacement (TAVR) with balloon-expandable (BE) or self-expanding (SE) transcatheter heart valves (THVs) is indicated for the treatment of high-risk patients with severe aortic stenosis. Limited data are available comparing the two THV designs, and evidence suggests that each may offer unique advantages. Herein are described two patients who underwent TAVR with BE-THV and SE-THV, and who each developed a device-related complication that was successfully treated by using the alternate THV design...
September 2015: Journal of Heart Valve Disease
Nora Goebel, Samir Ahad, Tim Schaeufele, Stephan Hill, Martin Beyer, Ralph Berroth, Ulrich F W Franke, Hardy Baumbach
BACKGROUND AND AIM OF THE STUDY: Transcatheter procedures are considered the therapy of choice for high-risk patients who are not eligible for surgical aortic valve replacement. Although its utility is debated, the logistic EuroSCORE I is still the most frequently used risk calculator for cardiac surgery in Europe, and was used in the present study to identify patients with an extremely high risk of predicted perioperative mortality. METHODS: This single-centre study included 319 consecutive patients who underwent transapical or transaortic transcatheter aortic valve implantation (TAVI) between September 2008 and December 2012...
September 2015: Journal of Heart Valve Disease
Vitor E E Rosa, Antonio S S A Lopes, Tarso A D Accorsi, Joao Ricardo C Fernandes, Guilherme S Spina, Roney O Sampaio, Fernando Bacal, Flavio Tarasoutchi
BACKGROUND AND AIM OF THE STUDY: International records indicate that only 2.6% of patients with heart transplants have valvular heart disease. The study aim was to evaluate the epidemiological and clinical profile of patients with valvular heart disease undergoing heart transplantation. METHODS: Between 1985 and 2013, a total of 569 heart transplants was performed at the authors' institution. Twenty patients (13 men, seven women; mean age 39.5 +/- 15.2 years) underwent heart transplant due to structural (primary) valvular disease...
September 2015: Journal of Heart Valve Disease
Dai-Hyun Kim, Han Ki Park, Young Hwan Park, Seung Hyun Lee, Hyun-Chel Joo, Sak Lee, Young-Nam Youn, Hong Ju Shin
BACKGROUND AND AIM OF THE STUDY: The degenerative calcification of bioprosthetic heart valves remains a clinical challenge, especially among young adults and children. Animal models that are based on subcutaneous and intramuscular implantation and are typically used to assess interventions to prevent bioprosthetic heart valve calcification do not reflect actual hemodynamic stress and lack direct blood contact. Thus, the study aim was to investigate bioprosthesis calcification at different implantation sites...
September 2015: Journal of Heart Valve Disease
Pauli Ohukainen, Juha Näpäkangas, Pasi Ohtonen, Heikki Ruskoaho, Panu Taskinen, Tuomas Peltonen, Jaana Rysä
BACKGROUND AND AIM OF THE STUDY: Calcified aortic valve disease (CAVD) is an actively regulated disease that shares pathophysiological hallmarks with atherosclerosis. One of these common features is extracellular matrix (ECM) remodeling, which consists of a dynamic degradation and deposition of the ECM composition. Granzymes (Grs) are ECM- degrading and pro-apoptotic proteases that have been detected in atherosclerotic lesions, but their role in CAVD remains unknown. METHODS: The expression of granzymes and perforin was characterized in heavily stenotic valves (n = 20) and control valves (n = 6) using quantitative RT-PCR and immunohistochemistry...
September 2015: Journal of Heart Valve Disease
Mustafa Ozan Gursoy, Suleyman Karakoyun, Macit Kalcik, Mahmut Yesin, Sabahattin Gunduz, Mehmet Ali Astarcioğlu, Ali Emrah Oğuz, Mehmet Ozkan
BACKGROUND AND AIM OF THE STUDY: Prosthetic valve dysfunction (PVD) due to pannus formation is considered to occur due to a bioreaction to prosthetic material. The p53 gene plays a critical role in apoptosis and cell proliferation. p53 Arg72Pro polymorphism has been found to be associated with coronary stent restenosis, but has not yet been studied in prosthetic heart valve dysfunction. The study aim was to evaluate the association between pannus-derived PVD and p53 G72C(Arg72Pro) polymorphism...
September 2015: Journal of Heart Valve Disease
Giordano Tasca, Riccardo Vismara, Gianfranco Beniamino Fiore, Andrea Mangini, Claudia Romagnoni, Alberto Redaelli, Carlo Antona
BACKGROUND AND AIM OF THE STUDY: Many variables may affect the fluid dynamic of an implanted bioprosthesis. In-vitro studies have provided accurate data such that, when different prostheses are implanted in the same true aortic root, it should be possible to make a fair comparison. The study aim was to evaluate the fluid dynamic and geometric characteristics of the four most widely used stented pericardial bioprostheses. METHODS: Four types of pericardial prosthesis (Magna Ease 21, Trifecta 21, Soprano-Armonia 20, and Mitroflow 23) that fitted eight aortic roots with a native annulus diameter of 2...
September 2015: Journal of Heart Valve Disease
Ahmed Sanoussi, Helene Demanet, Hughes Dessy, Martial Massin, Dominique Biarent, Andree Deville, Pierre Wauthy
BACKGROUND AND AIM OF THE STUDY: Ventricular septal defect (VSD) with aortic regurgitation (AR) is a well-known association. However, there is still no agreement about its management, particularly regarding the technical details of its operative treatment. The study aim was to describe all components of the syndrome and to evaluate the various techniques used with regards to its anatomical and functional features. METHODS: A total of 31 patients (mean age 7.4 years; range: 1...
September 2015: Journal of Heart Valve Disease
Takehiro Inoue, Takako Nishino, Kosuke Fujii, Toshihiko Saga
The case is reported of mitral valve repair with cusp-level chordal shortening for non-rheumatic mitral anterior leaflet prolapse. The simple and easily reproducible cusp-level shortening procedure consists of plication of the redundant chorda underneath the leaflet. Provided the chorda is thick enough, this procedure is more likely to be applied to regional mitral anterior prolapse due to elongation of the chorda, even in patients with non-rheumatic heart disease. The present patient underwent perioperative adaptive servo-ventilation (ASV) therapy...
September 2015: Journal of Heart Valve Disease
Reiko Toida, Nozomi Watanabe, Kikuko Obase, Yasufumi Nagata, Yuki Yoshimura, Hiroyuki Masuyarna, Takashi Fukunaga, Tomoko Fukuda, Tatsunori Toida, Tetsunori Ishikawa, Masaaki Takeuchi, Kazuo Kitamura, Kiyoshi Yoshida
BACKGROUND AND AIM OF THE STUDY: Functional mitral regurgitation (FMR) is a clinically important complication of left ventricular (LV) dysfunction, occurring as a result of geometric deformity in the mitral valve (MV) complex. The study aim was to determine whether tenting parameters derived from real-time three-dimensional echocardiography (RT3DE) can predict the long-term prognosis for patients with dilated cardiomyopathy (DCM). METHODS: Mitral valve tenting morphology, LV volume and function, and papillary muscle positions were monitored using transthoracic RT3DE in 75 subjects (66 with DCM, nine controls)...
September 2015: Journal of Heart Valve Disease
Marco Russo, Fabio Bertoldo, Paolo Nardi, Antonella D'Annolfo, Guglielmo Saitto, Antonio Pellegrino, Luigi Chiariello
BACKGROUND AND AIM OF THE STUDY: Bicuspid aortic valve (BAV), though normally functioning, is frequently associated with dilatation of the aortic root and ascending aorta. Optimal surgical treatment remains controversial. The study aim was to evaluate the fate of the normally functioning spared BAV at long-term follow up. METHODS: Forty patients (26 males, 14 females; mean age 59 +/- 11 years; range: 38-81 years) who underwent aortic surgery for proximal aortic disease between 1996 and 2011, with spared BAV at surgery, were included in the study...
September 2015: Journal of Heart Valve Disease
Ran Heo, Bríain Hartaighl, Iksung Cho, Valentina Valenti, Jonathon Leipsic, S Chiu Wong, Arash Salemi, Robert M Minutello, Geoffrey Bergman, James K Min
BACKGROUND AND AIM OF THE STUDY: Multidetector computed tomography (MDCT) is widely used for transcatheter aortic valve replacement (TAVR) planning, and its use predicts and prevents complications. To date, the reproducibility of aortoiliofemoral measurements and prediction of fluoroscopic angles for TAVR deployment remain inadequately studied. METHODS: Twenty-five consecutive patients (six males, 19 females; mean age 81.1 years) undergoing pre-procedural evaluation for TAVR were studied for 74 separate variables by MDCT...
September 2015: Journal of Heart Valve Disease
Kaoru Hattori, Ikuo Fukuda, Kazuyuki Daitoku, Wakako Fukuda, Masahito Minakawa, Yasuyuki Suzuki
BACKGROUND AND AIM OF THE STUDY: Patients with bicuspid aortic valve (BAV) have an increased risk of serious aortic complications such as aortic dissection, rupture and dilatation of the ascending aorta. Previous findings have suggested that ascending aortic dilatation with a BAV has a typical asymmetric configuration at the right-anterior aspect of the aorta. The study aim was to quantify asymmetric configurations of the aorta using a three-dimensional (3D) reconstruction tool. METHODS: A retrospective review was conducted of 52 patients (27 males, 25 females; mean age 69 ? 9 years) with aortic stenosis who presented with ascending aortic dilatation defined as an aortic diameter >35 mm...
September 2015: Journal of Heart Valve Disease
Alexander Blehm, Vitaly A Sorokin, Mikael Hartman, Khin Lay Wai, Karoline Schmitz, Artur Lichtenberg
BACKGROUND AND AIM OF THE STUDY: The health-related quality of life (QOL) is one of the most important outcome indicators for elderly people undergoing aortic valve interventions, and should be assessed across different interventions, including emerging percutaneous techniques. The study aim was to assess the change in QOL after different procedures for aortic valve replacement (AVR). METHODS: QOL was assessed using the Short Form-36 questionnaire (SF-36) for 59 patients after conventional AVR; of these patients, 28 had AVR via a J-sternotomy, a transapical approach was used in 20 patients, and a transfemoral approach in 34...
September 2015: Journal of Heart Valve Disease
Mohammed Hassan, Yongjie Miao, Ahmed Maraey, Joy Lincoln, Shelby Brown, Jimmy Windsor, Marco Ricci
BACKGROUND AND AIM OF THE STUDY: Minimally invasive aortic valve replacement via ministernotomy (ministernotomy-AVR) or minithoracotomy (minithoracotomy-AVR) is gaining popularity. To date, a direct comparison of ministernotomy-AVR versus minithoracotomy-AVR is lacking. The study aim was to compare these two procedures from a cost-benefit perspective. METHODS: Eight reports from the United States were selected from amongst 33,494 literature citations based on sample size and data completeness...
September 2015: Journal of Heart Valve Disease
Augusto D'Onofrio, Gino Gerosa
The development of new techniques for the treatment of almost all structural heart pathologies that do not require cardiopulmonary bypass and aortic cross-clamping, such as transcatheter aortic valve replacement and transapical mitral chordae implantation, define a new age of our specialty: the micro-invasive (microICS) cardiac surgery era.
September 2015: Journal of Heart Valve Disease
Siva Prasad Veerbhadran, Vivek Velayudhan Pillai, Bijulal Sasidharan, Jayakumar Karunakaran
BACKGROUND AND AIM OF THE STUDY: Congenital abnormalities of the tricuspid valve (TV), including dysplasia, straddling, and those associated with other congenital heart disease, are rare causes of tricuspid regurgitation (TR). In congenital TV anomalies there can be varying levels of abnormalities of leaflet and subvalvular structures. Herein is reported a case of TV cleft with absent chordae, and a technique of TV repair. METHODS: A 14-year-old boy was found to have severe TR due to dysplasia of the anterior TV leaflet...
July 2015: Journal of Heart Valve Disease
Antonio Segreto, Sergio De Salvatore, Alessandro Chiusaroli, Federico Bizzarri, Cornelius Van Wyk, Stefano Congiu
The case is described of an eight-year-old boy who required an operation for moderate mitral regurgitation due to a double-orifice mitral valve (DOMV). The DOMV, which was clearly demonstrated by transthoracic echocardiography, had a central fibrous bridge. Mitral valve repair using a 5/0 Prolene suture placed at the level of the superior commissure of each hole to stabilize the valve, and ring annuloplasty with Edwards Physio ring, was successfully performed. Intraoperative real-time transesophageal echocardiography showed the repaired DOMV to be without regurgitation or stenosis...
July 2015: Journal of Heart Valve Disease
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