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Biological & Pharmaceutical Bulletin

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https://www.readbyqxmd.com/read/28867717/effects-of-tripterygium-wilfordii-hook-f-induction-therapy-to-iga-nephropathy-patients-with-heavy-proteinuria
#1
Zhen Wang, Chao Yu, Li-Na Zhou, Xin Chen
Although some new drugs have been developed, Tripterygium wilfordii Hook F.(TWHF)has the merits of relatively lower price and fewer side effects. Unfortunately, the efficacy and safety of the TWHF (especially dosage 120mg/day) in the IgA nephropathy(IgAN) are still lacking. A cohort study including 49 IgAN patients with heavy proteinuria who received induction therapy was undertaken. Patients were divided into three groups: Prednisone (PRE), conventional-dose TWHF (CTW) and double-dose TWHF (DTW). The clinical features, laboratory data, histological manifestations and outcomes of the groups were compared...
September 1, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28855448/caffeine-has-a-synergistic-anticancer-effect-with-cisplatin-via-inhibiting-fanconi-anemia-group-d2-protein-monoubiquitination-in-hepatocellular-carcinoma-cells
#2
Yuichiro Oda, Muneaki Hidaka, Akito Suzuki
Cisplatin is an anticancer agent and induces DNA interstrand cross-links (ICLs). ICLs activate various signaling processes and induce DNA repair pathways, including the Fanconi anemia (FA) pathway. FA complementation group D2 (FANCD2) is monoubiquitinated in response to DNA damage, leading to activation of the DNA double-strand-break repair protein, RAD51. Caffeine increases the anticancer activity of cisplatin by inhibiting DNA repair; however, details of the mechanism remain unclear. We investigated the mechanism responsible for the synergistic anticancer effect of cisplatin and caffeine in HepG2 human hepatocellular carcinoma cells, focusing on the FA pathway...
August 31, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28845027/dibutyl-phthalate-rather-than-monobutyl-phthalate-facilitates-contact-hypersensitivity-to-fluorescein-isothiocyanate-in-a-mouse-model
#3
Kohta Kurohane, Kota Sekiguchi, Erina Ogawa, Masato Tsutsumi, Yasuyuki Imai
Dibutyl phthalate (DBP) is a plasticizer used for many consumer products including cosmetics. Potential health concerns regarding DBP include reproductive and developmental toxicity, endocrine disruption and neurotoxicity. DBP is a high priority chemical as to reduction of exposure of children to it. Through reproductive toxicity studies, monobutyl phthalate (MBP) has been proposed to be the active metabolite derived from DBP. We previously demonstrated that DBP activates transient receptor potential ankyrin 1 (TRPA1) cation channels expressed on sensory neurons...
August 26, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28835584/role-of-glyceraldehyde-derived-ages-and-mitochondria-in-superoxide-production-in-femoral-artery-of-oletf-rat-and-effects-of-pravastatin
#4
Eisei Hori, Chigusa Kikuchi, Chie Nagami, Junko Kajikuri, Takeo Itoh, Masayoshi Takeuchi, Tamihide Matsunaga
A complication of diabetes mellitus is the over-production of vascular superoxides, which contribute to the development of arteriosclerosis and peripheral arterial disease (PAD). Hyperglycemia induces the formation and accumulation of advanced glycation end-products (AGEs), which in turn stimulate vascular superoxide production. The mechanism underlying AGE-mediated vascular superoxide production remains to be clarified in lower limb complications associated with diabetes. In the present study, we investigated the role of AGEs and the mitochondrial respiratory complex in superoxide production in femoral arteries using the type 2 diabetes model Otsuka Long-Evans Tokushima Fatty (OLETF) rats [vs...
August 22, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28804104/%C3%AE-cyperone-inhibits-pma-induced-epcr-shedding-through-pkc-pathway
#5
Yu Ma, Yi Zhao, Ran Zhang, Xiaoxia Liang, Zhongqiong Yin, Yi Geng, Gang Shu, Xu Song, Yuanfeng Zou, Lixia Li, Lizi Yin, Guizhou Yue, Yinglun Li, Gang Ye, Changliang He
α-Cyperone, a sesquiterpene compound represents 25.23% of the total oil and is the most abundant compound in C. rotundus oil. Endothelial cell protein C receptor (EPCR) is a main member in Protein C (PC) anti-coagulation system. EPCR could be shed from cell surface, and is mediated by Tumor necrosis factor-α converting enzyme (TACE). Nothing that EPCR is a marker of vascular barrier integrity in vascular inflammatory disease and takes part in systemic inflammatory disease. In this study, we investigated whether α-cyperone could inhibit EPCR shedding...
August 11, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28768938/a-novel-molecular-model-of-plant-lectin-induced-programmed-cell-death-in-cancer
#6
Zheng Shi, Wen-Wen Li, Yong Tang, Li-Jia Cheng
Plant lectin, a class of highly diverse non-immune origin and carbohydrate-binding proteins, has been reported to specially induce cancer cell through programmed cell death (PCD) pathways (apoptosis and/or autophagy), shedding lights on screening promising anti-cancer candidate agent for further therapeutic trials. However, the complicated molecular mechanisms by which plant lectins induced the programmed death of tumor cells, have not yet been fully clarified. Here, we summarized a novel model, based on vast amount of research, by which plant lectins eliminate various types of cancer cells via three major pathways, including a) direct ribosome inactivating, b) endocytosis-dependent mitochondrial dysfunction and c) sugar-containing receptors binding...
August 1, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28747591/assessment-of-genetic-and-chemical-variability-in-curcumae-longae-rhizoma-curcuma-longa-l-based-on-dna-barcoding-markers-and-hplc-fingerprints
#7
Zhonggang Duan, Wei Song, Kuan Chen, Xue Qiao, Min Ye
Curcumae Longae Rhizoma (Curcuma Longa L.) is an important traditional Chinese medicine with multiple beneficial effects. To elucidate the genetic and chemical differences among Curcumae Longae Rhizoma samples, three DNA barcoding markers (rbcL, matK, and ITS-LSU D1/D3) and HPLC fingerprinting were employed in this study. The discriminatory power of rbcL and matK was low, as they only detected one sequence type that showed 100% similarity with more than 20 congeneric species in the BOLD database. In contrast, ITS-LSU D1/D3 showed sufficient discriminatory power to precisely identify all of the market samples as C...
July 26, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28659545/baicalein-protects-against-rotenone-induced-neurotoxicity-through-induction-of-autophagy
#8
Lianghong Kuang, Xiongbin Cao, Zuneng Lu
Baicalein, a typical flavonoid compound, has neuroprotective properties in several neurological disorders. Autophagy plays a central role in maintaining the cellular homeostasis, and is involved in the pathogenesis of Parkinson's disease (PD). Recently, baicalein has been reported to induce autophagy. Therefore, the current study was designed to investigate whether baicalein could protect against rotenone-induced neurotoxicity via induction of autophagy both in SH-SY5Y cells and in a mouse model. A chronic PD mouse model was established by continuous intragastric administration of rotenone for 12 weeks...
June 28, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28652557/study-of-ph-stability-of-r-salbutamol-sulfate-aerosol-solution-and-its-antiasthmatic-effects-in-guinea-pigs
#9
Qing Liu, Qingrui Li, Ting Han, Tingting Hu, Xuemei Zhang, Junhua Hu, Hui Hu, Wen Tan
Currently, all commercial available nebulized Salbutamol in China is in its racemic form. It is known that only R-salbutamol (eutomer) has therapeutic effects, while S-salbutamol (distomer) may exacerbate asthma after chronic use. Therefore, it is an unmet clinical need to develop R-salbutamol as a nebulized product that is more convenient for young and old patients. In our study, a stable aerosol solution of R-salbutamol sulfate was established, and its antiasthmatic effects were confirmed. The decomposition rate and racemization effect of the R-salbutamol sulfate solution were evaluated over a pH range from 1 to 10 (except pH = 7, 8) at 60 ℃...
June 24, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28637941/a-novel-danshensu-tetramethylpyrazine-conjugate-dt-010-provides-cardioprotection-through-the-pgc-1%C3%AE-nrf2-ho-1-pathway
#10
Xiaojing Zhang, Huihui Hu, Jingxiong Luo, Huixing Deng, Pei Yu, Zaijun Zhang, Gaoxiao Zhang, Luchen Shan, Yuqiang Wang
In this study, we investigated the cardioprotective mechanisms of action of DT-010, a novel danshensu-tetramethylpyrazine conjugate. DT-010 significantly preserved cell viability and suppressed cell apoptosis in H9c2 cells injured by tert-butylhydroperoxide (t-BHP), iodoacetic acid (IAA) and hypoxia-reoxygenation. In addition, DT-010 pre-treatment reduced the intracellular level of free radicals including superoxide anion (•O2(-)), hydroxyl radical (•OH) and peroxynitrite anion (ONOO(-)) after t-BHP exposure...
June 22, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28626167/a-human-glucagon-like-peptide-1-albumin-recombinant-protein-with-prolonged-hypoglycemic-effect-provides-efficient-and-beneficial-control-of-glucose-metabolism-in-diabetic-mice
#11
Caina Li, Miaomiao Yang, Guojiang Hou, Shuainan Liu, Yi Huan, Dongan Yu, Sujuan Sun, Quan Liu, Shousheng Yan, Zhufang Shen
GW002 is a recombinant protein engineered by fusing the C-terminal region of human glucagon-like peptide-1 (GLP-1) to the N-terminal region of human serum albumin (HSA) with a peptide linker. This study aims to evaluate its anti-diabetic effects both in vitro and vivo. The GLP-1 receptor-dependent luciferase reporter plasmid was transiently transfected in NIT-1 cells to calculate the half-maximal concentration (EC50) for GLP-1 receptor activation, and normal ICR mice and diabetic KKAy mice were acutely injected with GW002 (1, 3 and 9 mg/kg) subcutaneously to evaluate the hypoglycemic action, while the diabetic KKAy and db/db mice were treated with GW002 once daily for 7 weeks to evaluate the effects on glucose metabolism...
June 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28626198/the-therapeutic-effect-of-dexmedetomidine-on-rat-diabetic-neuropathy-pain-and-the-mechanism
#12
Yuecheng Lu, Baohua Lin, Junmin Zhong
Diabetic neuropathy pain (DNP) is a common chronic complication of diabetes characterized by spontaneous pain, hyperalgesia and allodynia. Dexmedetomidine is a selective α2 adrenergic agonist that relieves sympathetic nervous tension and reduces the release of glutamate. Thus, it is possible that dexmedetomidine may relieve DNP as well. In this study, we examined the effect of dexmedetomidine on DNP in the presence or absence of the α2 adrenergic antagonist yohimbine in rats utilizing a streptozotocin (STZ)-induced diabetes as a model of DNP...
June 14, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28626197/evaluation-of-cyp2d6-protein-expression-and-activity-in-the-small-intestine-to-determine-its-metabolic-capability-in-the-japanese-population
#13
Momoko Kawakami, Sachiko Takenoshita-Nakaya, Yuko Takeba, Yuki Nishimura, Masayuki Oda, Minoru Watanabe, Yuki Ohta, Shinjiro Kobayashi, Takehito Ohtsubo, Shinichi Kobayashi, Naoki Uchida, Naoki Matsumoto
CYP2D6 plays an important role in the metabolism of many drugs such as opioids and antidepressants. Polymorphisms of the CYP2D6 gene are widely observed in the Japanese population, and can affect the first-pass metabolism of orally administered drugs. Several CYP enzymes have been identified in the small intestine of Caucasians, but intestinal CYP enzymes have not been reported in the Japanese population, except for CYP3A4 and CYP2C19. In this study, we evaluated the CYP2D6 metabolic capacity by measurement of CYP2D6 mRNA and protein levels and activity in the small intestine of Japanese individuals...
June 14, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28603159/safety-profile-of-telaprevir-based-triple-therapy-in-elderly-patients-a-real-world-retrospective-cohort-study
#14
Maiko Akutagawa, Kazuki Ide, Yohei Kawasaki, Mie Yamanaka, Ryo Iketani, Hiroshi Yamada, Naohiko Masaki
To compare the rate of treatment discontinuation due to adverse events for telaprevir-based triple (T/PR) and pegylated interferon-alfa-2b and ribavirin (PR) therapy for the treatment of hepatitis C virus (HCV) infection in patients over the age of 65 years, in Japan.Retrospective analysis of the health data of patients over the age of 65 years treated for a HCV infection genotype 1 using T/PR or PR therapy, from 38 prefectures in Japan. The primary outcome was the rate of treatment discontinuation due to adverse events for T/PR and PR...
June 9, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28592715/synthesis-of-clovamide-analogues-that-inhibit-no-production-in-activated-bv-2-microglial-cells
#15
Ju-Young Park, Byung-Wook Kim, Hae Un Lee, Dong-Kug Choi, Sung-Hwa Yoon
A series of methyl ester of clovamide analogues, where the hydroxyl group of catechol moiety in caffeic acid and L-dopa was replaced with various functional groups, were synthesized and their inhibitory effects on nitric oxide (NO) production and inducible NO synthase expression in lipopolysaccharide-induced BV2 cells were tested. Among the synthesized compounds, 3,5-ditrifluoromethyl analogue 9l (IC50 = 2.8 μM) exhibited a potency about 26.3 times greater than that of the parent compound 9a (IC50 = 73.6 μM) and suppressed NO production dose-dependently without cytotoxicity...
June 8, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28579595/study-on-the-increased-probability-of-detecting-adverse-drug-reactions-based-on-bayes-theorem-evaluation-of-the-usefulness-of-information-on-the-onset-timing-of-adverse-drug-reactions
#16
Shinji Oshima, Takako Enjuji, Akio Negishi, Hayato Akimoto, Kousuke Ohara, Mitsuyoshi Okita, Sachihiko Numajiri, Naoko Inoue, Shigeru Ohshima, Akira Terao, Daisuke Kobayashi
In order to avoid adverse drug reactions (ADRs), pharmacists are reconstructing ADR-related information based on various types of data gathered from patients, and then providing this information to patients. Among the data provided to patients is the time-to-onset of ADRs after starting the medication (i.e., ADR onset timing information). However, a quantitative evaluation of the effect of onset timing information offered by pharmacists on the probability of ADRs occurring in patients receiving this information has not been reported to date...
June 3, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28579594/exploration-of-underlying-mechanism-of-anti-adipogenic-activity-of-sulfuretin
#17
Ramakanta Lamichhane, Se-Gun Kim, Sona Kang, Kyung-Hee Lee, Prakash Raj Pandeya, Hyun-Ju Jung
Sulfuretin is a natural flavonoid found in the plant Rhus verniciflua Stokes. The plant has been traditionally used as medicinal agent for antiviral, cathartic, diaphoretic, anti-rheumatic and sedative activities in East Asia. In this study we isolated and identified sulfuretin from R. verniciflua and investigated its anti-adipogenic activity against 3T3-L1 preadipocytes cells. We evaluated the effects of sulfuretin on the adipogenic transcription factors like PPARγ, C/EBPα, FAS, Fabp4, adiponectin and Zfp521 by gene expression (real-time QPCR) and Western blot analysis...
June 3, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28381813/development-of-polyethylene-glycol-and-hard-fat-based-mucoadhesive-tablets-containing-various-types-of-polyvinyl-alcohols-as-mucoadhesive-polymers-for-buccal-application
#18
Yuri Ikeuchi-Takahashi, Ayaka Kobayashi, Hiraku Onishi
Topical drug application has the advantage of avoiding systemic side effects. We attempted to develop a long-acting matrix-type tablet containing indomethacin (IM) with low physical stimulus and potent mucoadhesive force to treat pain caused by oral aphtha. A mixture of polyethylene glycol (PEG) and hard fat was used as the tablet base. Ethylcellulose was added to the base in an attempt to control drug release. Tablets with PEG as a base were also prepared for comparison. Polyvinyl alcohols (PVAs) with various degrees of saponification were added to increase the mucoadhesive force...
June 1, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28539527/effects-of-zebularine-on-invasion-activity-and-intracellular-expression-level-of-let-7b-in-colorectal-cancer-cells
#19
Shota Tanaka, Mika Hosokawa, Jyuri Matsumura, Emi Matsubara, Aika Kobori, Kumiko Ueda, Seigo Iwakawa
The effects of zebularine, a DNA methyltransferase inhibitor, on the invasion activity as well as intracellular expression level of let-7b, tumor suppressor microRNA, were examined in three human colorectal cancer (CRC) cell lines: SW480, SW620, and oxaliplatin-resistant SW620 (SW620/OxR). Zebularine suppressed the invasion activity of SW620 and SW620/OxR cells. The intracellular expression level of let-7b was up-regulated by zebularine in SW620 and SW620/OxR cells. The overexpression of let-7b by the transfection of let-7b mimic suppressed invasion activity in SW620 and SW620/OxR cells...
May 25, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28529241/downregulation-of-transcription-factor-sp1-suppresses-malignant-properties-of-a549-human-lung-cancer-cell-line-with-decreased-%C3%AE-4-galactosylation-of-highly-branched-n-glycans
#20
Kodai Muramoto, Riho Tange, Takayuki Ishii, Kana Miyauchi, Takeshi Sato
Dramatic changes in the glycan structures of cell surface proteins have been observed upon malignant transformation of cells as induced by the altered expression levels of glycosyltransferases. Such changes are closely associated with the malignant properties of cancer cells. Transcription factor Sp1 regulates the gene expression of various molecules including glycosyltransferases. Herein, we investigated whether or not Sp1-downregulation affects to N-glycosylation of glycoproteins and malignant properties of A549 human lung carcinoma cell line...
May 20, 2017: Biological & Pharmaceutical Bulletin
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