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Biological & Pharmaceutical Bulletin

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https://www.readbyqxmd.com/read/28228616/transcriptional-mechanism-of-the-%C3%AE-4-galactosyltransferase-4-gene-in-sw480-human-colon-cancer-cell-line
#1
Atena Sugiyama, Naomichi Fukushima, Takeshi Sato
Increased expression of β4-galactosyltransferase (β4GalT) 4 has been shown to be associated with metastatic ability and poor prognosis of colon cancer cells. To solve the up-regulation of β4GalT4 in colon cancer cells at transcriptional level, we examined the transcriptional mechanism of the β4GalT4 gene in SW480 human colon cancer cell line. Luciferase assay using the deletion constructs revealed that the promoter activity of the β4GalT4 gene is associated with the region between nucleotides -122 and -55 relative to the transcriptional start site, which contained one Sp1-binding site...
February 23, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28216512/risk-factors-for-treatment-discontinuation-caused-by-adverse-events-when-using-telaprevir-peginterferon-and-ribavirin-to-treat-chronic-hepatitis-c-a-real-world-retrospective-cohort-study
#2
Kazuki Ide, Yohei Kawasaki, Ryo Iketani, Naohiko Masaki
In this study, a nationwide database was used to identify the risk factors for treatment discontinuation due to adverse events during telaprevir, peginterferon, and ribavirin (T/PR) treatment, and estimate the increase in the occurrence of adverse events when patients have multiple risk factors at the same time. The risk factors were identified using univariate logistic regression analysis, and a Cochran-Armitage trend test was used to analyze the correlation between the number of risk factors and treatment discontinuation due to adverse events...
February 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28202839/cost-outcome-description-of-peg-ifn-%C3%AE-2b-rbv-for-hepatitis-c-results-based-on-the-interferon-database
#3
Maiko Akutagawa, Yohei Kawasaki, Atsuko Kawasaki, Kazuki Ide, Hiroshi Yamada, Naohiko Masaki
Economic evaluation of drugs is used in decision-making on medical care and public policy. Recently, real-world data (RWD) have been used in the analysis. In this study, we discuss the risk and benefits of using RWD for economic evaluation. We conducted a cost-outcome description with RWD from a nationwide registry providing information on hepatitis treatment in Japan and estimated the utility of the analysis. We evaluated the cost-outcome description of peginterferon plus ribavirin (PEG-IFN-α2b + RBV) treatment in hepatitis C virus (HCV)-infected patients...
February 15, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28190857/protective-effects-of-tyrosol-against-lps-induced-acute-lung-injury-via-inhibiting-nf-%C3%AE%C2%BAb-and-ap-1-activation-and-activating-the-ho-1-nrf2-pathways
#4
Wen-Chen Wang, Yan-Min Xia, Bo Yang, Xiang-Ni Su, Jia-Kuan Chen, Wei Li, Tao Jiang
Tyrosol (Tyr) is a natural antioxidant that displays anti-oxidant and anti-inflammatory properties. The present study aimed to investigate the effect and mechanism of Tyr on lipopolysaccharide (LPS)-induced acute lung injury (ALI). In a mouse model, we found that pretreatment with Tyr significantly improved survival rate, attenuated lung permeability, ameliorated histopathological alterations, reduced expression of the inflammatory mediators and improved expression of the antioxidant enzyme. Further study revealed that Tyr markedly inhibited nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) activation at both in vivo and in vitro levels...
February 10, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28179602/the-safety-profile-of-telaprevir-based-triple-therapy-in-clinical-practice-a-retrospective-cohort-study
#5
Ryo Iketani, Kazuki Ide, Hiroshi Yamada, Yohei Kawasaki, Naohiko Masaki
This study was designed to evaluate the safety profile of adding telaprevir to therapy using pegylated interferon-alfa-2b and ribavirin (PR) using real world patient data obtained from a nationwide Japanese interferon database. This retrospective cohort study compared telaprevir-based triple therapy (T/PR) with PR therapy. The study population comprised patients with genotype 1 chronic hepatitis C represented in the database between December 2009 and August 2015. The primary endpoint was dropout from treatment due to adverse events during the relevant standard treatment duration based on guidelines from the Japan Society of Hepatology...
February 9, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28163294/metabolic-suppression-by-3-iodothyronamine-induced-muscle-cell-atrophy-via-activation-of-foxo-proteasome-signaling-and-downregulation-of-akt1-s6k-signaling
#6
Hyunwoo Ju, Taewan Kim, Chan-Moon Chung, Junsoo Park, Takeshi Nikawa, Kyoungsook Park, Inho Choi
The homeostasis of muscle properties depends on both physical and metabolic stresses. Whereas physical stress entails metabolic response for muscle homeostasis, the latter does not necessarily involve the former and may thus solely affect the homeostasis. We here report that metabolic suppression by the hypometabolic agent 3-iodothyronamine (T1AM) induced muscle cell atrophy without physical stress. We observed that the oxygen consumption rate of C2C12 myotubes decreased 40% upon treatment with 75 μM T1AM for 6 h versus 10% in the vehicle (dimethyl sulfoxide) control...
February 3, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28123134/effects-of-combined-treatment-with-branched-chain-amino-acids-citric-acid-l-carnitine-coenzyme-q10-zinc-and-various-vitamins-in-tumor-bearing-mice
#7
Hiroko Awa, Akihiko Futamura, Takashi Higashiguchi, Akihiro Ito, Naoharu Mori, Miyo Murai, Hiroshi Ohara, Takeshi Chihara, Takaaki Kaneko
A functional dietary supplement (FDS) containing Coenzyme Q10, Branched-chain Amino Acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues. Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen of 8- to 9-week-old C57BL/6J mice. The mice were divided into two groups: a FDS group that received oral administration of FDS (n=10), and a control group that received oral administration of glucose (n=10).The moribund condition was used as the endpoint, and median survival time was determined...
January 26, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28123152/the-anti-dementia-effects-of-donepezil-involve-mir-206-3p-in-the-hippocampus-and-cortex
#8
Cheng-Niu Wang, Ying-Jie Wang, Hao Wang, Lu Song, Yu Chen, Jin-Liang Wang, Ying Ye, Bo Jiang
Alzheimer's disease (AD) is a most serious age-related neurodegenerative disorder accompanied with significant memory impairments in this world. Recently, microRNAs have been reported to be invlolved in the pathophysiology of AD. Previous studies have shown that miR-206 is implicated in the pathogenesis of AD via suppressing the expression of BDNF in the brain. Here, we examined the miR-206-3p and miR-206-5p expression in the hippocampus and cortex of APP/PS1 transgenic mice treated with donepezil, a drug approved for treating AD in clinic...
January 25, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28111380/baicalin-protects-against-tnf-%C3%AE-induced-injury-by-down-regulating-mir-191a-that-targets-the-tight-junction-protein-zo-1-in-iec-6-cells
#9
Li Wang, Ren Zhang, Jian Chen, Qihui Wu, Zaoyuan Kuang
TNF-α plays an important role in the developing process of inflammatory bowel disease. Tight junction protein zonula occludens-1 (ZO-1), one of epithelial junctional proteins, maintains the permeability of intestinal barrier. The objective of this study was to investigate the mechanism of the protective effect of baicalin on TNF-α-induced injury and ZO-1 expression in intestinal epithelial cells (IECs). We found that baicalin pretreatment significantly improved cell viability and cell migration following TNF-α stimulation...
January 20, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100868/growth-inhibition-of-refractory-human-gallbladder-cancer-cells-by-retinol-and-its-mechanism-of-action
#10
Chuan Li, Masahiko Imai, Shinya Hasegawa, Masahiro Yamasaki, Noriko Takahashi
Among the constituents of the essential nutrient vitamin A, retinol is a potent suppressor of refractory cancer cell growth linked to tumor progression, showing greater efficacy than retinoic acid (RA). However, the mechanisms of retinol action on human refractory cancer are not known well. In the current study, we examined the actions of retinol on proliferation of human gallbladder cancer NOZ C-1 cells. Retinol and RA inhibited the proliferation of human NOZ C-1 cells in dose-dependent manner, while RA was less potent than retinol...
January 18, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100867/effects-of-pre-and-post-administration-of-vitamin-a-on-the-growth-of-refractory-cancers-in-xenograft-mice
#11
Chuan Li, Masahiko Imai, Masahiro Yamasaki, Shinya Hasegawa, Noriko Takahashi
Vitamin A is an essential nutrient that is obtained from the daily diet. The major forms of vitamin A in the body consist of retinol, retinal, retinoic acid (RA), and retinyl esters. Retinal is fundamental for vision and RA is used in clinical therapy of human acute promyelocytic leukemia. The actions of retinol and retinyl palmitate (RP) are not known well. Recently, we found that retinol is a potent anti-proliferative agent against human refractory cancers, including gallbladder cancer, being more effective than RA, while RP was inactive...
January 18, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100866/development-of-intra-knee-joint-sustained-release-gel-formulation-and-evaluation-of-its-pharmacological-efficiency-in-rats
#12
Takehiro Noda, Tomoyuki Okuda, Kousuke Ban, Ryota Mizuno, Tatsuaki Tagami, Tetsuya Ozeki, Hirokazu Okamoto
In the development of a drug for intra-articular administration, a sustained-release formulation is desirable since it is difficult to sustain the effects of conventional injections due to fast drug leakage from the joint cavity. In this study, we prepared sustained release gel formulations for intra-articular administration containing indocyanine green (ICG) as a model drug to follow its fate after intra-articular administration in rats with IVIS. ICG administered as an aqueous solution leaked from the joint cavity in a short time and was excreted out of the body within a day...
January 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28003606/solubility-testing-of-sucrose-esters-of-fatty-acids-in-international-food-additive-specifications
#13
Yukino Nagai, Satoko Kawano, Kenichiro Motoda, Masaaki Tomida, Chiye Tatebe, Kyoko Sato, Hiroshi Akiyama
We investigated the solubility of 10 samples of sucrose esters of fatty acids (SEFA) products that are commercially available worldwide as food additives (emulsifiers). Although one sample dissolved transparently in both water and ethanol, other samples produced white turbidity and/or precipitates and did not meet the solubility criterion established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA). When the sample solutions were heated, the solubility in both water and ethanol increased. All of the samples dissolved transparently in ethanol, and dispersed and became white without producing precipitates in water...
December 20, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27990002/cinepazide-maleate-improves-cognitive-function-and-protects-hippocampal-neurons-in-diabetic-rats-with-chronic-cerebral-hypoperfusion
#14
Yumei Li, Ting Zhang, Xiaojie Zhang, Wenying Zou, Xian Gong, Jianliang Fu
To determine the combined effect of type 2 diabetes (T2D) and chronic cerebral hypoperfusion (CCH) on learning and spatial memory, we developed a rat model of CCH by permanent occlusion of bilateral common carotid arteries (2VO) in high-fat diet (HFD)-fed rats injected with low-dose streptozotocin (STZ). Furthermore, we examined the effect of cinepazide maleate (CM) on cognitive deficits and brain damage in this rat model. Rats were maintained on HFD for 6 weeks and then injected with 35 mg/kg STZ to induce T2D...
December 17, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27980245/synthesis-and-characterization-of-8-nitroguanosine-3-5-cyclic-monophosphorothioate-rp-isomer-as-a-potent-inhibitor-of-protein-kinase-g1%C3%AE
#15
Khandaker Ahtesham Ahmed, Tianli Zhang, Katsuhiko Ono, Hiroyasu Tsutsuki, Tomoaki Ida, Soichiro Akashi, Keishi Miyata, Yuichi Oike, Takaaki Akaike, Tomohiro Sawa
Guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinases (PKG) are kinases regulating diverse physiological functions including vascular smooth muscle relaxation, neuronal synaptic plasticity, and platelet activities. Certain PKG inhibitors, such as Rp-diastereomers of derivatives of guanosine 3',5'-cyclic monophosphorothioate (Rp-cGMPS), have been designed and used to study PKG-regulated cell signaling. 8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) is an endogenous cGMP derivative formed as a result of excess production of reactive oxygen species and nitric oxide...
December 16, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27980244/a-clinical-study-on-administration-of-opioid-antagonists-in-terminal-cancer-patients
#16
Yoshihiro Uekuzu, Takashi Higashiguchi, Akihiko Futamura, Akihiro Ito, Naoharu Mori, Miyo Murai, Hiroshi Ohara, Hiroko Awa, Takeshi Chihara
There have been few detailed reports on respiratory depression due to overdoses of opioids in terminal cancer patients. We investigated the situation of treatment with opioid antagonists for respiratory depression that occurred after administration of opioid at optimal doses in terminal cancer patients, to clarify pathological changes as well as causative factors. In 2,443 terminal cancer patients receiving opioids, 7 patients (0.3%) received opioid antagonists: 6, morphine (hydrochloride, 5; sulfate, 1); 1, oxycodone...
December 16, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27980242/a-novel-analytical-method-of-cisplatin-using-the-high-performance-liquid-chromatography-with-a-naphthylethyl-group-bonded-with-silica-gel-%C3%AF-nap-column
#17
Ryuji Kato, Takaji Sato, Michiko Kanamori, Mizuho Miyake, Ayumi Fujimoto, Kyohei Ogawa, Daiki Kobata, Tomoya Fujikawa, Yukari Wada, Rintaro Mitsuishi, Kodai Takahashi, Hideki Imano, Yoshio Ijiri, Yoshiki Mino, Masahiko Chikuma, Kazuhiko Tanaka, Tetsuya Hayashi
Cisplatin is the most widely used anticancer drug in the world. Mono-chloro and none-chloro complexes of cisplatin may be believed to be the activated compounds. The separation of these compounds using octa decyl silyl column or aminopropylsilyl silica gel column is difficult because of high-reactivity and structural similarity. In this study, cisplatin, hydroxo complexes, and OH-dimer were determined by high-performance liquid chromatography (HPLC) using a naphthylethyl group bonded with silica gel (π NAP) column...
December 14, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27916764/serotonergic-system-does-not-contribute-to-the-hypothermic-action-of-acetaminophen
#18
Akihiro Fukushima, Wakana Sekiguchi, Kizuku Mamada, Yumi Tohma, Hideki Ono
Acetaminophen (AcAP), a widely-used antipyretic and analgesic drug, has been considered to exert its effects via central mechanisms, and many studies have demonstrated that the analgesic action of AcAP involves activation of the serotonergic system. Although the serotonergic system also plays an important role in thermoregulation, the contribution of serotonergic activity to the hypothermic effect of AcAP has remained unclear. In the present study, we examined whether the serotonergic system is involved in AcAP-induced hypothermia...
February 1, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28154265/inhibitory-activities-of-antioxidant-flavonoids-from-tamarix-gallica-on-amyloid-aggregation-related-to-alzheimer-s-and-type-2-diabetes-diseases
#19
Asma Ben Hmidene, Mizuho Hanaki, Kazuma Murakami, Kazuhiro Irie, Hiroko Isoda, Hideyuki Shigemori
The prevention of amyloid aggregation is promising for the treatment of age-related diseases such as Alzheimer's (AD) and type 2 diabetes (T2D). Ten antioxidant flavonoids isolated from the medicinal halophyte Tamarix gallica were tested for their amyloid aggregation inhibition potential. Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs. Structure-activity relationship of the flavonoids suggests that the catechol moiety is important for amyloid aggregation inhibition, while the methylation of the carboxyl group in the glucuronide moiety and of the hydroxyl group in the aglycone flavonoids decreased it...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28154264/modifying-cationic-liposomes-with-cholesteryl-peg-prevents-their-aggregation-in-human-urine-and-enhances-cellular-uptake-by-bladder-cancer-cells
#20
Takashi Nakamura, Yosuke Noma, Yu Sakurai, Hideyoshi Harashima
Intravesical drug delivery by cationic liposomes (Cat-LPs) represents a potent nanotechnology for enhancing therapeutic effects against bladder disorders. However, preventing the aggregation of Cat-LPs in urine poses a significant barrier. We report on an examination of the effect of modifying liposomes with polyethylene glycol (PEG) lipids to prevent Cat-LPs from aggregating in human urine. Although Cat-LPs underwent significant aggregation in human urine, introducing 5 mol% of PEG2k lipid or 2 mol% of PEG5k lipid completely inhibited the aggregation of the Cat-LPs...
2017: Biological & Pharmaceutical Bulletin
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