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Wound Repair and Regeneration

Maria J Kowzun, William J Rifkin, Zachary M Borab, Trevor Ellison, Marc A Soares, Stelios C Wilson, Philip Lotfi, Amey Bandekar, Stavroula Sofou, Pierre B Saadeh, Daniel J Ceradini
Radiation therapy is an effective treatment strategy for many types of cancer but is limited by its side effects on normal tissues, particularly the skin, where persistent and progressive fibrotic changes occur and can impair wound healing. In this study, we attempted to mitigate the effects of irradiation on skin using a novel transcutaneous topical delivery system to locally inhibit p53 upregulated modulator of apoptosis (PUMA) gene expression with small interfering RNA (siRNA). In an isolated skin irradiation model, the dorsal skin of C57 wild-type mice was irradiated...
August 29, 2018: Wound Repair and Regeneration
Clark A Bonham, Melanie Rodrigues, Michael Galvez, Artem Trotsyuk, Zachary Stern-Buchbinder, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Chronic wounds are a significant medical and economic problem worldwide. Individuals over the age of 65 are particularly vulnerable to pressure ulcers and impaired wound healing. With this demographic growing rapidly there is a need for effective treatments. We have previously shown that defective hypoxia signaling through destabilization of the master hypoxia-inducible factor 1α (HIF-1α) underlies impairments in both aging and diabetic wound healing. To stabilize HIF-1α, we developed a transdermal delivery system of the FDA-approved small molecule deferoxamine (DFO) and found that transdermal DFO could both prevent and treat ulcers in diabetic mice...
August 28, 2018: Wound Repair and Regeneration
Kenneth R Thistlethwaite, Kathleen J Finlayson, P David Cooper, Bebe Brown, Michael H Bennett, Graeme Kay, Maria T O'Reilly, Helen E Edwards
Over 30% of venous leg ulcers do not heal despite evidence-based treatment. This study aimed to determine the effectiveness of Hyperbaric Oxygen Therapy (HBOT) as an adjunct treatment for non-healing venous leg ulcers. A randomised, double-blind, parallel group, placebo-controlled trial was undertaken in three hyperbaric medicine units. Adults with a venous leg ulcer, Transcutaneous Oxygen Measurement indicative of a hypoxic wound responsive to oxygen challenge, and without contraindications for HBOT; were eligible...
August 21, 2018: Wound Repair and Regeneration
Lindsay A Dawson, Paula P Schanes, Patrick Kim, Felisha M Imholt, Osama Qureshi, Connor P Dolan, Ling Yu, Mingquan Yan, Katherine N Zimmel, Alyssa R Falck, Ken Muneoka
While mammals cannot regenerate amputated limbs, mice and humans have regenerative ability restricted to amputations transecting the digit tip, including the terminal phalanx (P3). In mice the regeneration process is epimorphic and mediated by the formation of a blastema comprised of undifferentiated proliferating cells that differentiate to regenerate the amputated structures. Blastema formation distinguishes the regenerative response from a scar-forming healing response. The mouse digit tip serves as a pre-clinical model to investigate mammalian blastema formation and endogenous regenerative capabilities...
August 18, 2018: Wound Repair and Regeneration
Mari Shimizu, Hajime Matsumine, Hironobu Osaki, Yoshihumi Ueta, Satoshi Tsunoda, Wataru Kamei, Kazuki Hashimoto, Yosuke Niimi, Yorikatsu Watanabe, Mariko Miyata, Hiroyuki Sakurai
Adipose-derived stem cells (ADSCs) and the stromal vascular fraction (SVF) promote nerve regeneration. Biodegradable nerve conduits are used to treat peripheral nerve injuries, but their efficiencies are lower than those of autologous nerve grafts. This study developed biodegradable nerve conduits containing ADSCs and SVF and evaluated their facial nerve regenerating abilities in a rat model with a 7-mm nerve defect. SVF and ADSCs were individually poured into nerve conduits with PGA-type I collagen as a scaffold (ADSCs and SVF groups)...
August 17, 2018: Wound Repair and Regeneration
Jian Jin, Xingfeng Zheng, Fang He, Yongcun Zhang, Hao Zhou, Pengfei Luo, Xiaoyan Hu, Zhaofan Xia
This study aimed to investigate the role of photobiomodulation therapy in preventing zones of stasis in burn wounds. We hypothesized that photobiomodulation therapy could promote tissue formation and release of nitric oxide (NO) through a photochemical reaction, and reduce local inflammatory responses, thereby dilating local microvessels, reducing necrosis and apoptosis. Thirty rats were randomly divided into control (CG) and laser groups (LG) (15 per group). The zone of stasis was formed by applying a hot brass comb to the skin resulting in 4 rectangular burns separated by 3 unburned interspaces...
August 17, 2018: Wound Repair and Regeneration
Luis J Borda, Jose A Jaller, Penelope J Kallis, Flor E MacQuhae, Ingrid Herskovitz, Joshua D Fox, Katherine L Baquerizo, Robert S Kirsner
Understanding and managing patients' expectations can help improve their adherence to treatment for chronic wounds; however, little is known concerning about their expectations regarding healing time. Recruited subjects were asked to predict how long their wounds would take to heal and their charts were reviewed to retrieve real time of healing. We recruited 100 subjects from which 77% have healed. Fifty-three subjects (68.8%) had a longer healing time than they predicted (underestimated), and 17 (22.1%) had a shorter healing time than they predicted (overestimated)...
August 17, 2018: Wound Repair and Regeneration
Rachel Sommer, Carsten Hampel-Kalthoff, Brigitte Kalthoff, Christopher Neht, Erwin Scherfer, Manfred Winkler, Christine Blome
The purpose of this study was to examine the self- and proxy-report agreement on the Wound-QoL questionnaire to assess health-related quality of life in patients with chronic wounds. Patients and their proxies (in this case relatives) were recruited via different nursing services in Germany and asked to complete the Wound-QoL. Intraclass correlation coefficients were calculated for each Wound-QoL scale and the total score, and weighted Cohen's Kappa coefficients for individual items. Proxies tended to report lower health-related quality of life in the Wound-QoL than their relatives with chronic wounds...
August 17, 2018: Wound Repair and Regeneration
Corrie L Gallant-Behm, Joseph Piper, Brent A Dickinson, Christina M Dalby, Linda A Pestano, Aimee L Jackson
There is a strong unmet need for new therapeutics to accelerate wound healing across both chronic and acute indications. It is well established that local tissue hypoxia, vascular insufficiency and/or insufficient angiogenesis contribute to inadequate wound repair in the context of diabetic foot ulcers as well as to other chronic wounds such as venous stasis and pressure ulcers. microRNA-92a-3p (miR-92a) is a potent anti-angiogenic miRNA whose inhibition has led to increases in angiogenesis in multiple organ systems, resulting in an improvement in function following myocardial infarction, limb ischemia, vascular injury and bone fracture...
August 17, 2018: Wound Repair and Regeneration
Line Bisgaard Jørgensen, Sune Møller Skov-Jeppesen, Ulrich Halekoh, Benjamin Schnack Rasmussen, Jens Ahm Sørensen, G B Jemec, Knud Bonnet Yderstraede
In order to monitor wound healing it is essential to obtain accurate and reliable wound measurements. Various methods have been used to measure wound size including three-dimensional (3D) measurement devices enabling wound assessment from a volume perspective. However, the currently available methods are inaccurate, costly or complicated to use. As a consequence, we have developed a 3D-WAM camera (Wound Assessment Monitor camera), which is able to measure wound size in three-dimension and to assess wound characteristics...
August 17, 2018: Wound Repair and Regeneration
Rodolfo H Silva, Alexei M C Machado
Pressure ulcers are skin lesions caused by the excessive compression of soft tissues between bones and hard surfaces that may increase treatment risks and costs. Manual techniques to evaluate the area of the affected region include the use of adhesive labels and rulers in direct contact with the ulcer. In this paper, a semi-automatic method is proposed to estimate the lesion area through computerized techniques in different color spaces using filters and morphological operators. Experiments with a set of 110 images of pressure ulcers resulted in a statistically significant increase in effectiveness, when compared to other published results, reaching 90...
August 12, 2018: Wound Repair and Regeneration
Huidi Tchero, Pauline Kangambega, Lazarre Noubou, Beatrice Becsangele, Fluieraru Sergiu, Luc Teot
Diabetic foot infection is a common diabetic complication that may end in lower limb amputation if not treated properly. We performed this systematic review to assess the clinical efficacy of different antibiotic regimens, whether systemic or topical, in the treatment of moderate to severe diabetic foot infections. We searched Medline, Web of Science, SCOPUS, Cochrane CENTRAL and ScienceDirect for randomized controlled trials that evaluated the efficacy of antibiotic regimens in moderate to severe diabetic foot infections...
August 12, 2018: Wound Repair and Regeneration
Keshvad Hedayatyanfard, Seyed Ali Ziai, Feizollah Niazi, Iman Habibi, Behnam Habibi, Hamideh Moravvej
Keloid and hypertrophic scars are two types of fibrosis caused by extracellular matrix overexpression, and angiotensin II via AT1 receptor is known to play a key role in stimulation of fibrosis. A pilot placebo controlled single blind study was carried out on patients with hypertrophic scars and keloids. A total of 37 adult volunteers were randomly assigned into losartan 5% or placebo treatment groups. The treatment was performed twice a day for three months and a six-month follow up. The treatment was evaluated using Vancouver scar scale method...
August 12, 2018: Wound Repair and Regeneration
Walison N Silva, Caroline Leonel, Pedro H D M Prazeres, Isadora F G Sena, Daniel A P Guerra, Debora Heller, Ivana M A Diniz, Vitor Fortuna, Akiva Mintz, Alexander Birbrair
Dermal wound healing is the process of repairing and remodeling skin following injury. Delayed or aberrant cutaneous healing pose a challenge for the health-care system. The lack of detailed understanding of cellular and molecular mechanisms involved in this process hamper the development of effective targeted treatments. In a recent study, Parfejevs and colleagues, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP techniques in combination with a mouse model of excisional cutaneous wounding, reveal that Schwann cells induce adult dermal wound healing...
August 11, 2018: Wound Repair and Regeneration
Charles E Ananian, Yadwinder S Dhillon, Carl C Van Gils, D Craig Lindsey, Raymond J Otto, Cyaandi R Dove, Jessica T Pierce, Molly C Saunders
Randomized controlled clinical trials, the gold standard to determine treatment efficacy against control, have demonstrated advantages of skin substitutes for the treatment of chronic diabetic foot ulcers in comparison to standard of care. However, randomized controlled clinical trials comparing efficacy between two or more skin substitutes are very limited. With growing numbers of new skin substitutes, such studies are essential for treatment and policy-making decisions by wound care providers and payers. In this study, we analyzed clinical outcomes and product cost between a viable cryopreserved placental membrane (vCPM) and a human fibroblast-derived dermal substitute (hFDS) for the treatment of chronic diabetic foot ulcers in a prospective, multicenter, single-blind study...
August 11, 2018: Wound Repair and Regeneration
Jose A Jaller, Joshua Mervis, Robert S Kirsner
No abstract text is available yet for this article.
August 11, 2018: Wound Repair and Regeneration
Isha Ranadive, Sonam Patel, Pranav Buch, Uggini Gowrikumari, Isha Desai, Suresh Balakrishnan
Lizards are unique in having both - regeneration competent (tail) as well as non-regenerating appendages (limbs) in adults. They therefore present an appropriate model for comparing processes underlying regenerative repair and non-regenerative healing after amputation. In the current study, we use northern house gecko Hemidactylus flaviviridis to compare major cellular and molecular events following amputation of the limb and of the tail. Although the early response to injury in both cases comprises apoptosis, proliferation and angiogenesis, the temporal distribution of these processes in each remained obscure...
July 28, 2018: Wound Repair and Regeneration
Emily L Durham, Rebecca N Howie, Reed Houck, Brayden Oakes, Zachary Grey, SarahRose Hall, Martin Steed, Amanda LaRue, Robin Muise-Helmericks, James Cray
Large craniofacial defects present a substantial clinical challenge that often requires the use of osteoconductive matrices and osteoinductive cues (i.e. Bone Morphogenetic Proteins (BMP2)) to augment healing. While these methods have improved clinical outcomes, a better understanding of how the osteogenic fronts surrounding the defect, the underlying dura mater, and the cranial suture area contribute to healing may lead to more targeted therapies to enhance bone regeneration. We hypothesized that healing within a large bone defect will be precipitated from cells within the remaining or available suture mesenchyme abutting the edges of a murine critical sized defect...
July 28, 2018: Wound Repair and Regeneration
Andrew Jull, Sara Muchoney, Varsha Parag, Angela Wadham, Chris Bullen, Jill Waters
Venous insufficiency is the most common cause of leg ulceration, but the impact of venous leg ulceration on health-related quality of life has not been adequately assessed. This study compared data from randomized controlled trials to population norms obtained from a large national population survey. We combined the baseline Short Form-36 (SF-36) version 1 data from two New Zealand randomized controlled trials that recruited participants with VLU and compared the pooled data to the population scores obtained from the New Zealand Health Survey using general linear regression to adjust for age, sex, and ethnicity differences between the cohorts...
July 17, 2018: Wound Repair and Regeneration
Andrew W Holt, Jennifer S McDaniel, Gregory T Bramblett, Elof E Eriksson, Anthony J Johnson, Gina L Griffith
Current therapies available to treat and heal ocular surface injuries and periocular burns are frequently inadequate, costly, and labor intensive. To address these limitations, we have employed a flexible, semi-transparent ocular wound chamber (OWC) to provide protection as well as a watertight seal to allow for the constant delivery of therapeutics to the ocular surface and surrounding periocular tissue. This study demonstrates the safety and utilization of the OWC on uninjured eyes and in our exposure keratopathy model...
June 26, 2018: Wound Repair and Regeneration
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