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Wound Repair and Regeneration

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https://www.readbyqxmd.com/read/28727229/volatile-organic-compound-detection-as-a-potential-means-of-diagnosing-cutaneous-wound-infections
#1
Mohammed Ashrafi, Matt Bates, Mohamed Baguneid, Teresa Alonso-Rasgado, Riina Rautemaa-Richardson, Ardeshir Bayat
Chronic cutaneous wound infections and surgical site infections (SSIs) present a huge burden on the healthcare system and can lead to increased morbidity and mortality. Current diagnostic methods of identifying and confirming infection involve culture-based and molecular methods. Both techniques are time consuming and delays commonly lead to un-targeted empirical treatment. An ideal diagnostic method would be non-invasive and highly sensitive and detect pathogenic organisms with a high degree of accuracy in order to allow targeted treatment...
July 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28727221/scar-formation-following-excisional-and-burn-injuries-in-a-red-duroc-pig-model
#2
Britani N Blackstone, Jayne Y Kim, Kevin L McFarland, Chandan K Sen, Dorothy M Supp, J Kevin Bailey, Heather M Powell
Scar research is challenging because rodents do not naturally form excessive scars, and burn depth, size, and location cannot be controlled in human longitudinal studies. The female, red Duroc pig model has been shown to form robust scars with biological and anatomical similarities to human hypertrophic scars. To more closely mimic the mode of injury, recreate the complex chemical milieu of the burn wound environment and enhance scar development, an animal model of excessive burn-induced scarring was developed and compared with the more commonly used model, which involves excisional wounds created via dermatome...
July 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28727215/neutrophil-extracellular-traps-coincide-with-a-pro-coagulant-status-of-microcirculatory-endothelium-in-burn-wounds
#3
H Ibrahim Korkmaz, Magda M W Ulrich, Sanne Vogels, Tim de Wit, Paul P M van Zuijlen, Paul A J Krijnen, Hans W M Niessen
Burn-induced tissue loss is partly related to secondary expansion of necrosis into vital dermis neighbouring the initial burn injury. An important factor herein is the severe loss of perfusion of the burn wound, probably caused by microvascular damage induced by the intense local inflammatory responses as well as burn-induced hypercoagulation. We hypothesize that the formation of Neutrophilic Extracellular Traps (NETs) play an important role in this. The purpose of this study was to investigate post-burn intravascular thrombosis, NETs formation and the coagulant state in the microvasculature of burns in both animal models and patients...
July 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28665034/ultrahigh-dose-gentamicin-alters-inflammation-and-angiogenesis-in-vivo-and-in-vitro
#4
Melissa A Olekson, Lloyd F Rose, Anders H Carlsson, John L Fletcher, Kai P Leung, Rodney K Chan
Skin quality outcome after skin grafting is adversely affected by wound bed inflammation. Neomycin, gentamicin, and other aminoglycoside antibiotics are known to modulate inflammation, and topical application affords the use of higher doses than are possible to use systemically. Previous data suggest that clinically relevant doses of neomycin, but not gentamicin, may impair angiogenesis, which is critical to the durable survival of skin grafts. The role of gentamicin at ultrahigh doses compared with clinically relevant neomycin doses in regulating inflammatory expression and angiogenesis has been examined...
June 30, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28628259/exercise-prior-to-but-not-concomitant-with-stress-reverses-stress-induced-delayed-skin-wound-healing
#5
Bianca O Saguie, Bruna Romana-Souza, Rayssa L Martins, Andréa Monte-Alto-Costa
Stress-induced prolonged inflammation impairs cutaneous wound healing. Exercise may inhibit this effect via an anti-inflammatory mechanism. Our aim was to investigate the effect of moderate exercise on skin wound healing in chronically stressed mice. Mice were trained five times per week on a treadmill or received no training. Mice underwent daily rotational stress from the 6th week until euthanasia. During the 8th week, two wounds were created in the dorsum and collected 10 days later. A control group only received wounds...
June 19, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28597990/temporal-dynamics-of-relative-abundances-and-bacterial-succession-in-chronic-wound-communities
#6
Craig D Tipton, Marilyn E Mathew, Richard A Wolcott, Randall D Wolcott, Tigga Kingston, Caleb D Phillips
Polymicrobial bacterial infection is an important factor contributing to wound chronicity. Consequently, clinicians frequently adopt a biofilm-based wound care approach, in which wounds are treated utilizing DNA sequencing information about microbial communities. While more successful than treatment not using community information, there is little information about temporal dynamics of wound communities and optimal approaches over the course of treatment. To characterize these dynamics, temporal analysis over three sampling points was conducted for 167 chronic wounds...
June 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28597935/failure-rates-of-artificial-dermis-products-in-treatment-of-diabetic-foot-ulcer-a-systematic-review-and-network-meta-analysis
#7
Huidi Tchero, Christian Herlin, Farid Bekara, Pauline Kangambega, Fluieraru Sergiu, Luc Teot
Diabetic foot ulcer (DFU) is a frequent complication in diabetic patients, occurring in up to 25% of those affected. Among the treatments available to clinicians, the use of bioengineered skin substitutes is an attractive alternative. Artificial dermis functions as a matrix, covering the wound and supporting healing and reconstruction of the lost tissue. This study was aimed at reviewing the use of five regeneration matrices (namely, Integra, Nevelia, Matriderm, Pelnac, and Renoskin) as reported by clinical trials...
June 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28544322/in-vitro-skin-expansion-wound-healing-assessment
#8
Peter M Prim, Han Su Kim, Lindsey E Shapiro, Jae Sung Lee, James H Kaan, John D Jackson, James J Yoo, Anthony Atala, Sang Jin Lee
For treatments requiring split-thickness skin grafts, it is preferable to mesh the grafts. This reduces the amount of excised skin and covers more wound area. The mesh technique, however, destroys surface continuity, which results in scarring. Strain-based bioreactors, on the other hand, have successfully expanded split-thickness skin grafts in vitro within a 7-day period, increasing graft coverage. After in vitro expansion, the expanded skin grafts were tested in a porcine full-thickness excisional wound model...
May 24, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28544150/a-randomized-clinical-trial-of-a-human-acellular-dermal-matrix-demonstrated-superior-healing-rates-for-chronic-diabetic-foot-ulcers-over-conventional-care-and-an-active-acellular-dermal-matrix-comparator
#9
Shawn Cazzell, Dean Vayser, Hau Pham, Jodi Walters, Alexander Reyzelman, Brian Samsell, Kimberly Dorsch, Mark Moore
This study compared the efficacy and safety of a human acellular dermal matrix (ADM), D-ADM, with a conventional care arm and an active comparator human ADM arm, GJ-ADM, for the treatment of chronic diabetic foot ulcers. The study design was a prospective, randomized controlled trial that enrolled 168 diabetic foot ulcer subjects in 13 centers across 9 states. Subjects in the ADM arms received one application but could receive one additional application of ADM if deemed necessary. Screen failures and early withdrawals left 53 subjects in the D-ADM arm, 56 in the conventional care arm, and 23 in the GJ-ADM arm (2:2:1 ratio)...
May 24, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28513105/hair-follicle-specific-acvr1-alk2-critically-affects-skin-morphogenesis-and-attenuates-wound-healing
#10
Michael Sorkin, Shailesh Agarwal, Kavitha Ranganathan, Shawn Loder, David Cholok, David Fireman, John Li, Shuli Li, Bin Zhao, Yuji Mishina, Paul Cederna, Benjamin Levi
The bone morphogenic protein signaling (BMP) is intricately involved in the quiescence and regulation of stem cells through activation of BMP receptors. Hair follicle stem cells play a critical role in cutaneous homeostasis and regeneration. Here, we utilize a novel mouse model with targeted overexpression of the BMP receptor ALK2/ACVR1 in hair follicle stem cells, to characterize its role in skin development and postnatal wound healing. Initial histologic evaluation demonstrated significant dysregulation in hair follicle morphogenesis in mutant mice...
May 17, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28494521/topical-1-propranolol-cream-promotes-cutaneous-wound-healing-in-spontaneously-diabetic-mice
#11
Zhifang Zheng, Yishu Liu, Yu Yang, Jianbing Tang, Biao Cheng
Diabetic foot ulcers (DFUs) are a constant threat to diabetic patients and can lead to amputations and even death. Intralesional administration of propranolol in diabetic wounds has not been reported previously. This study aimed to investigate the efficacy of propranolol cream in diabetic wounds. Fifty-six spontaneously diabetic mice were divided into the propranolol group and the control group. After preparing full-thickness wounds on the back of the mice, 1% propranolol cream was topically applied to wounds in the experimental group and 0% propranolol cream in controls...
May 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28494512/gene-expression-profiling-of-skeletal-muscle-after-volumetric-muscle-loss
#12
Kristo Nuutila, Dharaniya Sakthivel, Carla Kruse, Peter Tran, Giorgio Giatsidis, Indranil Sinha
Volumetric muscle loss (VML), usually occurring following traumatic injury, results in a composite loss of muscle mass. These injuries manifest as decreased strength and functional impairments. Clinically, these injuries often heal with fibrosis, as opposed to skeletal muscle regeneration. The present study examines the healing patterns of a skeletal muscle following VML in a murine model. Eight-week old male C57BL/6J mice used in the study underwent either bilateral VML injury or cryoinjury, a widely-used model known to induce skeletal muscle regeneration...
May 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28494507/subepidermal-moisture-detection-of-pressure-induced-tissue-damage-on-the-trunk-the-pressure-ulcer-detection-pud-study-outcomes
#13
Barbara M Bates-Jensen, Heather E McCreath, Anabel Patlan
We examined the relationship between subepidermal moisture measured using surface electrical capacitance and visual skin assessment of pressure ulcers at the trunk location (sacral, ischial tuberosities) in 417 nursing home residents residing in 19 facilities. Participants were on average older (mean age of 77 years), 58% were female, over half were ethnic minorities (29% African American, 12% Asian American, and 21% Hispanic), and at risk for pressure ulcers (mean score for Braden Scale for Predicting Pressure Ulcer Risk of 15...
May 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28493324/level-specific-amputations-and-resulting-regenerative-outcomes-in-the-mouse-distal-phalanx
#14
Connie S Chamberlain, Justin J Jeffery, Ellen M Leiferman, Tugrul Yildirim, Xin Sun, Geoffrey S Baer, William L Murphy, Ray Vanderby
Mouse digit tip regeneration involves an intricate coordinated regrowth of the terminal phalanx, nail, dermis and epidermis. During this time, regenerating digits undergo wound healing, blastema formation, and differentiation. However, the regenerative response of the digit is dependent on the level of the amputation. Amputation of <30% of the distal phalanx (P3), with part of the base nail remaining, results in extensive digit regeneration. In contrast, >60% P3 removal results in no regeneration. This level-dependent regenerative ability of the mouse digit provides a comparative model between regeneration and non-regeneration that may enable identification of specific factors critical to regeneration...
May 10, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28466497/histopathological-comparisons-of-staphylococcus-aureus-and-pseudomonas-aeruginosa-experimental-infected-porcine-burn-wounds
#15
Sarah B Chaney, Kasturi Ganesh, Shomita Mathew-Steiner, Paul Stromberg, Sashwati Roy, Chandan K Sen, Daniel J Wozniak
Chronic skin wounds are a significant human health concern and are often complicated by infection with Pseudomonas aeruginosa and Staphylococcus aureus, particularly methicillin resistant S. aureus (MRSA). Translating the knowledge gained from extensive study of virulence mechanisms and pathogenesis of these bacterial species to new treatment modalities has been lacking in part due to a paucity of animal models able to recapitulate human disease. Our groups recently described a novel porcine chronic burn wound model for the study of bacterial infection; however, the histopathology of infection has yet to be described...
May 2, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28466489/characterization-of-mycobacterium-marinum-infections-in-zebrafish-wounds-and-sinus-tracts
#16
Ling Chen, Zhen Liu, Yingjun Su, Di Wang, Bin Yin, Bin Shu, Jishen Zhang, Xiaoyan Zhu, Chiyu Jia
The impaired healing of Mycobacterium tuberculosis-infected wounds is a clinical challenge, and the mechanisms involved are still not clear. The zebrafish model of Mycobacterium marinum infection has provided surprising insights into the pathogenesis of tuberculosis in humans. Similarly, the major principles and phases of cutaneous wound healing are conserved among adult mammals and adult zebrafish. Here, we injected Mycobacterium marinum into the dorsal muscles of adult zebrafish and observed the development of chronic wound pathology...
May 2, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28464475/isolation-of-cd248-expressing-stromal-vascular-fraction-for-targeted-improvement-of-wound-healing
#17
Elizabeth Brett, Elizabeth R Zielins, Monica Chin, Michael Januszyk, Charles P Blackshear, Michael Findlay, Arash Momeni, Geoffrey C Gurtner, Michael T Longaker, Derrick C Wan
Wound healing remains a global issue of disability, cost, and health. Addition of cells from the stromal vascular fraction (SVF) of adipose tissue has been shown to increase the rate of full thickness wound closure. This study aimed to investigate the angiogenic mechanisms of CD248+ SVF cells in the context of full thickness excisional wounds. Single cell transcriptional analysis was used to identify and cluster angiogenic gene-expressing cells, which was then correlated with surface marker expression. SVF cells isolated from human lipoaspirate were FACS sorted based on the presence of CD248...
May 2, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28463433/report-on-the-1st-european-tissue-repair-society-summer-school-london-june-29-to-july-1-2016
#18
LETTER
Chrysovalantou Faniku, Irene Castellano-Pellicena, Tamara Hoppenbrouwers, H Ibrahim Korkmaz
No abstract text is available yet for this article.
April 30, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28437853/inhibition-of-tgf-%C3%AE-signaling-promotes-expansion-of-human-epidermal-keratinocytes-in-feeder-cell-co-culture
#19
Daisuke Suzuki, Filipa Pinto, Makoto Senoo
Cultured epidermal autografts have been used worldwide since 1981 for patients with extensive third-degree burn wounds and limited skin donor sites. Despite significant progress in techniques toward improving clinical outcome of skin grafts, the long in vitro preparation time of cultured autografts has remained a major factor limiting its widespread use. Here, we show that pharmacological inhibition of TGF-β signaling promotes the expansion of human epidermal keratinocytes (HEKs) with high proliferative potential in co-cultures with both murine 3T3-J2 cells and human feeder cells, including dermal fibroblasts and preadipocytes...
April 24, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28419727/endotoxin-testing-of-a-wound-debridement-device-containing-medicinal-lucilia-sericata-larvae
#20
Samantha Pickles, David Pritchard
Alimentary products of medicinal Lucilia sericata larvae are studied to determine their mechanisms of action, particularly in the contexts of wound debridement and disinfection. Furthermore, the larvae can be applied to patients in contained medical devices (such as the BioBag; BioMonde). Here, we tested the materials and larval content of the most commonly used debridement device (the "BB-50") to explore the possibility that endotoxins may be contributing to the bio-activity of the product, given that endotoxins are potent stimulants of cellular activation...
April 17, 2017: Wound Repair and Regeneration
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