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Wound Repair and Regeneration

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https://www.readbyqxmd.com/read/29770531/use-of-antibiotic-impregnated-resorbable-beads-reduces-pressure-ulcer-recurrence-a-retrospective-analysis
#1
Ibrahim Khansa, Jenny C Barker, Piya Das Ghatak, Chandan K Sen, Gayle M Gordillo
BACKGROUND: Recurrence of pressure ulcers remains common. We have employed resorbable antibiotic beads as a therapeutic strategy to deliver high local antibiotic concentrations to the debridement site. Our objective was to determine whether the use of resorbable antibiotic- beads would reduce pressure ulcer recurrence. METHODS: We reviewed all stage IV pressure ulcers treated with excision, partial ostectomy and flap coverage over 16 years. Baseline patient factors (location of ulcer, presence of osteomyelitis, preoperative prealbumin), surgical factors (type of flap, use of antibiotic beads, bone culture results) and postoperative outcomes (ulcer recurrence at 1 year, dehiscence, seroma, cellulitis) were collected...
May 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29719102/risk-factors-for-hypertrophic-burn-scar-pain-pruritus-and-paresthesia-development
#2
Yongqiang Xiao, Yu Sun, Banghui Zhu, Kangan Wang, Pengfei Liang, Wenjun Liu, Jinfeng Fu, Shiqing Zheng, Shichu Xiao, Zhaofan Xia
Hypertrophic scar pain, pruritus, and paresthesia symptoms are major and particular concerns for burn patients. However, because no effective and satisfactory methods exist for their alleviation, the clinical treatment for these symptoms is generally considered unsatisfactory. Therefore, their risk factors should be identified and prevented during management. We reviewed the medical records of 129 post-burn hypertrophy scar patients and divided them into two groups for each of three different symptoms based on the University of North Carolina "4P" Scar Scale: patients with scar pain requiring occasional or continuous pharmacological intervention (HSc pain, n=75) vs...
May 2, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29683538/effectiveness-of-viable-cryopreserved-placental-membranes-for-management-of-diabetic-foot-ulcers-in-a-real-world-setting
#3
Katherine M Raspovic, Dane K Wukich, Daniel Q Naiman, Lawrence A Lavery, Robert S Kirsner, Paul J Kim, John S Steinberg, Christopher E Attinger, Alla Danilkovitch
In a multicenter randomized controlled trial (RCT), the use of viable cryopreserved placental membrane (vCPM) for chronic diabetic foot ulcers (DFUs) resulted in a higher proportion of wound closure in comparison to good wound care: 62% vs. 21% (p < 0.01). However, patients in RCTs are not representative of daily physician practice. Healthcare databases serve as a valuable tool to evaluate therapy effectiveness and to supplement evidence from RCTs. The objective of this study was to evaluate the effectiveness of vCPM for DFU management using Net Health's WoundExpert® electronic health records (EHR)...
April 23, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29663654/nifurpirinol-a-more-potent-and-reliable-substrate-compared-to-metronidazole-for-nitroreductase-mediated-cell-ablations
#4
David Bergemann, Laura Massoz, Jordane Bourdouxhe, Claudio A Carril Pardo, Marianne L Voz, Bernard Peers, Isabelle Manfroid
The zebrafish is a popular animal model with well-known regenerative capabilities. To study regeneration in this fish, the nitroreductase/metronidazole-mediated system is widely used for targeted ablation of various cell types. Nevertheless, we highlight here some variability in ablation efficiencies with the metronidazole prodrug that led us to search for a more efficient and reliable compound. Herein, we present nifurpirinol, another nitroaromatic antibiotic, as a more potent prodrug compared to metronidazole to trigger cell-ablation in nitroreductase expressing transgenic models...
April 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29663583/a-mathematical-model-for-the-determination-of-mouse-excisional-wound-healing-parameters-from-photographic-data
#5
Nicholas G Cogan, Alana P Mellers, Bhavi N Patel, Brett D Powell, Manu Aggarwal, Kathleen M Harper, Michael Blaber
We present a mathematical model to quantify parameters of mouse excisional wound healing from photographic data. The equation is a piecewise linear function in log scale that includes key parameters of initial wound radius (R0 ), an initial wound stasis phase (Ti ), and time to wound closure (Tc ); subsequently, these terms permit calculation of a latter active proliferative phase (Tp ), and the healing rate (HR) during this active phase. A daily photographic record of wound healing (utilizing 6 mm diameter splinted excisional wounds) permits the necessary sampling for robust parameter refinement...
April 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29663582/the-skin-microbiome-of-wound-scars-and-unaffected-skin-in-patients-with-moderate-to-severe-burns-in-the-subacute-phase
#6
Su-Hsun Liu, Yhu-Chering Huang, Leslie Y Chen, Shu-Chuan Yu, Hsiao-Yun Yu, Shiow-Shuh Chuang
Although studies on skin microbiome of acute and chronic wounds abound, evidence on newly-built microbial communities of subacute wounds remains scant. To characterize the skin microbiome of recently-healed (scarred) burn wounds in relation to unaffected skin surfaces, we collected weekly swabs from patients with moderate to severe burns in the 3rd postburn month for 4 weeks in 2015. We performed skin type (moist, dry, and oily)-matched comparisons within six burn patients (43 pairs of swabs) and with 13 skin-healthy, control patients (22 pairs of samples) using 16S ribosomal RNA (rRNA) gene sequencing results...
April 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29617058/multicenter-randomized-controlled-observer-blinded-study-of-a-nitric-oxide-generating-treatment-in-foot-ulcers-of-patients-with-diabetes-pronox1-study
#7
Michael E Edmonds, Harvey J Bodansky, Andrew Jm Boulton, Paul J Chadwick, Cuong N Dang, Ryan D'Costa, Atholl Johnston, Brian Kennon, Graham Leese, Satyan M Rajbhandari, Thomas E Serena, Matthew J Young, Joanne E Stewart, Arthur T Tucker, Marissa J Carter
The aim of this multi-center, prospective, observer-blinded, parallel group, randomized controlled trial was to assess the safety and efficacy of EDX110, a nitric oxide generating medical device, in the treatment of diabetic foot ulcers in a patient group reflecting "real world" clinical practice compared against optimal standard care. Participants were recruited from ten hospital sites in multidisciplinary foot ulcer clinics. The ulcers were full thickness, with an area of 25-2500mm2 and either a palpable pedal pulse or ankle brachial pressure index >0...
April 4, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29617055/-development-of-a-large-volume-human-derived-adipose-acellular-allogenic-flap-aafs-by-perfusion-decellularization
#8
Giorgio Giatsidis, Jacques P Guyette, Harald C Ott, Dennis P Orgill
In reconstructive surgery, transfer of patients' tissue (autologous flaps) is routinely used to repair large soft tissue defects caused by surgery, trauma, chronic diseases, or malformations; unfortunately, this strategy is not always possible and often creates a secondary defect in the donor site of the tissue. Tissue-engineered synthetic flaps are currently unable to repair clinically-relevant, large-volume defects; allogenic flaps from cadaveric donors could provide a ready-to-use biological alternative if treated with methods to avoid the immune-rejection of the donor's cells...
April 4, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29603518/wound-swab-and-wound-biopsy-yield-similar-culture-results
#9
Marieke Haalboom, Miriam H E Blokhuis-Arkes, Roland J Beuk, Rob Klont, Georg Guebitz, Andrea Heinzle, Job van der Palen
The question remains whether wound swabs yield similar culture results to the traditional gold standard, biopsies. Swabs are not invasive and easy to perform. However, they are believed to capture microorganisms from the surface rather than microorganisms that have invaded tissue. Several studies compared swabs and biopsies using different populations and sampling methods, complicating the ability to draw conclusions for clinical practice. This study aimed to compare swab and biopsy in clinical practice, by including a variety of wounds and using standard sampling and culture procedures...
March 30, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29569418/monitoring-of-ph-and-temperature-of-neuropathic-diabetic-and-non-diabetic-foot-ulcers-for-12-weeks-an-observational-study
#10
G Gethin, G M O'Connor, J Abedin, J Newell, L Flynn, D Watterson, A O'Loughlin
Wound bed assessment is largely reliant on subjective interpretation without recourse to objective tools or biomarkers. The identification of a point of care, reliable biomarker would enhance assessment and ultimately clinical decision-making. Two potentially emerging wound biomarkers exist: surface pH and surface temperature. To date, knowledge of their use has been predominantly in wound prevention, in vitro studies and single time measurements. Our objective was to determine surface pH, size and surface temperature in non-infected, neuropathic foot ulcers at baseline and at 12 weeks...
March 22, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29528167/silver-oxysalts-promote-cutaneous-wound-healing-independent-of-infection
#11
Helen A Thomason, Jodie M Lovett, Carla J Spina, Christian Stephenson, Andrew J McBain, Matthew J Hardman
Chronic wounds often exist in a heightened state of inflammation whereby excessive inflammatory cells release high levels of proteases and reactive oxygen species (ROS). While low levels of ROS play a fundamental role in the regulation of normal wound healing, their levels need to be tightly regulated to prevent a hostile wound environment resulting from excessive levels of ROS. Infection amplifies the inflammatory response, augmenting levels of ROS which creates additional tissue damage that supports microbial growth...
March 12, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29524350/changes-in-pge2-signaling-after-submandibulectomy-alter-post-tooth-extraction-socket-healing
#12
Claudia Ester Mohn, Gastón Rodolfo Troncoso, Clarisa Bozzini, María Inés Conti, Javier Fernandez Solari, Juan Carlos Elverdin
Saliva is very important to oral health, and a salivary deficit has been shown to bring serious problems to oral health. There is scant information about the mechanisms through which salivary glands participate in post-tooth extraction socket healing. Therefore, the aim of the present study was to investigate the effect of submandibulectomy (SMx), consisting of the ablation of submandibular and sublingual glands (SMG and SLG, respectively), on PGE2 signaling and other bone regulatory molecules, such as OPG and RANKL, involved in tooth extraction socket healing...
March 10, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29524343/translation-and-validation-of-the-chinese-powerlessness-assessment-tool
#13
Yao Huang, YueLai Yang, Pengwen Ni, Xian Xiao, JunNa Ye, Gang Kui, Ting Xie
The objectives of this study were to translate the powerlessness assessment tool (PAT) into Chinese, and to evaluate its psychometric performance. The PAT was translated into Chinese and was evaluated in patients with chronic wounds. Mean PAT scores were compared between various wound types to evaluate the scale's power to differentiate wound severity (PUSH score). There were 154 consecutive patients included in this study. All items were included, and the results of item-domain correlation (r ranged from 0...
March 10, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29330940/extracorporeal-shockwave-therapy-for-treatment-of-keloid-scars
#14
Ching-Jen Wang, Jih-Yang Ko, Wen-Yi Chou, Jai-Hong Cheng, Yur-Ren Kuo
The purpose of this investigation was to study the effectiveness of extracorporeal shockwave therapy (ESWT) for the treatment of keloid scars, and compared the results with intralesional steroid injection. Thirty-nine patients were randomly divided into 22 in ESWT group and 17 in steroid group. The ESWT group received 3 ESWT treatments in 6 weeks. The steroid group received three intra-lesional triamcinolone injections in 6 weeks. The evaluations included gross morphology, functional outcome, local blood flow perfusion, biopsy for histopathological examination, and immunohistochemical analysis...
January 13, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29668125/30-th-annual-meeting-of-the-wound-healing-society-sawc-spring-whs-joint-meeting-charlotte-convention-center-charlotte-north-carolina-usa-april-25-29-2018
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29505164/enoxaparin-does-not-affect-network-formation-of-adipose-tissue-derived-microvascular-fragments
#16
Thomas Später, Florian S Frueh, Philipp Karschnia, Michael D Menger, Matthias W Laschke
Dermal substitutes are frequently used for the initial coverage of extensive skin defects. The seeding of these implants with adipose tissue-derived microvascular fragments (ad-MVF) has recently been shown to accelerate their vascularization and incorporation. In the present study we analyzed whether these processes are affected by a thromboprophylactic therapy with the low molecular weight heparin (LMWH) enoxaparin (enox). Green fluorescent protein (GFP)+ ad-MVF were isolated from enox- (8 mg/kg s.c.) and vehicle-treated (0...
January 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29453855/nerve-reinnervation-and-itch-behavior-in-a-rat-burn-wound-model
#17
Tiam M Saffari, Barthold N Schüttenhelm, Johan W van Neck, Jan C Holstege
In this study, we investigated whether postburn itch in rats, after a full thickness burn, is correlated to the nervous reinnervation of the burn wound area. For this purpose, we determined scratching duration (expressed as second/hour) at 24 hours, 2, 4, 8, and 12 weeks postburn and combined this with immunohistochemistry for protein gene product 9.5 (PGP9.5) to identify all nerve fibers, calcitonin gene related peptide (CGRP) to identify peptidergic fibers, tyrosine hydroxylase (TH) for sympathetic fibers, and growth-associated protein 43 (GAP-43) for regrowing fibers...
January 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29453851/dicer-inactivation-stimulates-limb-regeneration-ability-in-xenopus-laevis
#18
Mengshi Zhang, Li Yang, Feng Yuan, Ying Chen, Gufa Lin
The ontogenetic decline of regeneration capacity in the anuran amphibian Xenopus makes it an excellent model for regeneration studies. However, the cause of the regeneration ability decline is not fully understood. MicroRNAs regulate animal development and have been indicated in various regeneration situations. However, little is known about the role of microRNAs during limb regeneration in Xenopus. This study investigates the effect of Dicer, an enzyme responsible for microRNA maturation, on limb development and regeneration in Xenopus...
January 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29424945/in-vitro-and-in-vivo-investigation-of-a-novel-amniotic-based-chitosan-dressing-for-wound-healing
#19
Maryam Momeni, Mohammad Zarehaghighi, Mirhamed Hajimiri, Ghasemali Khorasani, Rassoul Dinarvand, Abdolhossein Nekookar, Niloofar Sodeifi, Pardis Khosravani, Niloofar Shayanasl, Marzieh Ebrahimi
It is more than a decade that amniotic membrane has been used as a wound dressing because of its anti-inflammatory, anti-microbial, anti-fibrotic, anti-scarring properties, as well as its pain relieving and epithelialization promoting features. However, amniotic membrane had limited applications because it needs to suture in surgery, is highly fragile, firmly adhere to the wound and may cause bleeding and pain when changing the bandage. This study investigated the possibility of development of a novel amniotic-based chitosan gel dressing as a potential wound repair substrate with marked efficacy...
January 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29418044/vacuolar-atpase-is-required-for-erk-dependent-wound-healing-in-the-drosophila-embryo
#20
Juan J Fraire-Zamora, Matias Simons
Epithelia have the ability to repair injuries through an evolutionary conserved wound healing mechanism. Wound healing events can be classified into the transcription-independent signals involving mobilization of ionic currents and cytoskeletal rearrangements or the transcription-dependent response with activation of repair genes. The vacuolar H+ -ATPase (V-ATPase) has been implicated in the regeneration of vertebrate structures, but the underlying cellular mechanisms remain unclear. Here, we use wounding assays on the epidermis of Drosophila embryos to assess the role of the V-ATPase in the healing response...
January 2018: Wound Repair and Regeneration
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