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Wound Repair and Regeneration

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https://www.readbyqxmd.com/read/30394625/modulation-of-vegf-and-mapk-related-pathway-involved-in-extracorporeal-shockwave-therapy-accelerate-diabetic-wound-healing
#1
Rong-Fu Chen, Chih-Hau Chang, Chun-Ting Wang, Ming-Yu Yang, Ching-Jen Wang, Yur-Ren Kuo
BACKGROUND: Extracorporeal shockwave therapy (ESWT) has a significant positive effect to accelerate chronic wound healing. This study investigated whether the VEGF- related pathway has involved in ESWT enhancement of diabetic wound healing. METHODS: In this study, we used a dorsal skin defect (area, 6×5 cm) in a streptozotocin (STZ)-induced diabetes rodent model. Thirty-two male Wistar rats were divided into 4 groups. Group I consisted of non-diabetic control; group II, diabetic control without treatment; group III, diabetic rats received ESWT, and group IV, rats received Avastin (a VEGF monoclonal antibody) on day 0 (post-wounding immediately) to days 7 and ESWT on days 3 and day 7...
November 5, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30378215/novel-negative-pressure-wound-therapy-device-without-foam-or-gauze-is-effective-at-50-mmhg
#2
Kristo Nuutila, Lu Yang, Michael Broomhead, Karl Proppe, Elof Eriksson
Negative pressure wound therapy (NPWT) promotes healing in acute or chronic wounds. Conventional NPWT devices consist of a filler (such as foam or gauze) that covers the wound and of a permeable membrane and tubing that connects the space under the membrane to a suction pump. The permeable membrane increases airflow and thus increases the required pump capacity that can cause patient discomfort or even ischemia in wounds with compromised vascularity. In addition, foam or gauze may fragment and become colonized with bacteria over time...
October 31, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30368971/comparing-the-influence-of-two-immunosuppressants-fingolimod-azathioprine-on-wound-healing-in-a-rat-model-of-primary-and-secondary-intention-wound-closure
#3
Ricardo Ginestal, Bárbara Perez-Köhler, Paloma Pérez-López, Marta Rodríguez, Gemma Pascual, David Cebrián, Juan M Bellón, Francisca García-Moreno
In this study, rat models of wound closure by first and second intention were developed to evaluate the influence that two immunosuppressants for treating multiple sclerosis (fingolimod, azathioprine) have on wound healing. Sixty-three Sprague-Dawley rats were daily treated with fingolimod (0.6 mg/kg), azathioprine (2.5 mg/kg) or placebo (saline). Following 6 weeks of treatment, a linear incision (1.5 cm) or a circular excisional defect (diameter 1.5 cm) was made on the dorsal skin. The treatments were uninterrupted and after 7 days (incisional) or 21 days (incisional, excisional), animals were euthanized (n = 7 per group and time-point)...
October 28, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30368969/interleukin-33-encourages-scar-formation-in-murine-fetal-skin-wounds
#4
Brian C Wulff, Nicholas K Pappa, Traci A Wilgus
The magnitude of the inflammatory response after skin injury is important for determining whether wounds in developing fetal skin will heal scarlessly (minimal inflammation) or with prominent scars (robust inflammation). One class of inflammatory mediators gaining attention for their role in wound inflammation is alarmins. In the current study, the alarmin IL-33 was examined in a mouse model of fetal wound healing. IL-33 expression was elevated in scar-forming embryonic day 18 wounds compared to scarless embryonic day 15 wounds...
October 28, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30362661/renal-dysfunction-aggravated-impaired-cutaneous-wound-healing-in-diabetic-mice
#5
Ping Xie, Mimi Wu Young, Huining Bian, Solmaz Niknam-Bienia, Seok Hong, Thomas A Mustoe, Robert D Galiano
Renal dysfunction has been associated with poor outcomes of wound healing in the diabetic population. The purpose of this study was to create an excisional wound healing model in diabetic mice with renal dysfunction to investigate the combined effects of diabetes and nephropathy on cutaneous ulcers. Renal impairment was introduced in diabetic db/db mice through unilateral nephrectomy and electro-coagulation of the contralateral kidney. Renal function was subsequently monitored with assays of blood urea nitrogen (BUN) and spot urinary protein/creatinine ratio...
October 26, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30362646/the-humanistic-and-economic-burden-of-chronic-wounds-a-systematic-review
#6
REVIEW
Maja Olsson, Krister Järbrink, Ushashree Divakar, Ram Bajpai, Zee Upton, Artur Schmidtchen, Josip Car
Chronic wounds are a health problem that have devastating consequences for patients and contribute major costs to healthcare systems and societies. To understand the magnitude of this health issue, a systematic review was undertaken. Searches were conducted in MEDLINE, EMBASE, EBM Reviews and Cochrane library, CINAHL, EBSCO, PsycINFO, and Global Health databases for articles published between 2000 and 2015. Included publications had to target adults (≥18 years of age), state wound chronicity (≥3 weeks) and/or label the wounds as chronic, complex, hard-to-heal, or having led to an amputation...
October 26, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30338888/visualized-identification-of-the-maximal-surgical-delay-effect-in-a-rat-flap-model
#7
Xiucun Li, Miao Chen, Zhenmin Jiang, Yang Liu, Laijin Lu, Xu Gong
PURPOSES: Currently, experimental evidence suggests that the surgical delay can increase flap survival area, but its effect may decrease if the optimal delay period is missed. The aim of this study is to establish a sensitive and objective modality based on the visualized and individualized infrared thermography for identifying the maximal surgical delay effect. METHODS: A rectangular three-angiosome flap was designed on the unilateral dorsum of the rat. Ninety-six rats were randomly divided into 6 groups according to the various delay time...
October 19, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30324666/does-laser-therapy-improve-the-wound-healing-process-after-tooth-extraction-a-systematic-review
#8
REVIEW
Carmen Helena Jacques Lemes, Wellington Luiz de O da Rosa, Camila Leal Sonego, Bianca Jacques Lemes, Rafael Ratto de Moraes, Adriana Fernandes da Silva
Laser therapy could amplify the oral wound healing process by stimulating cell regeneration after injury, attenuating pain, and modulating the immune system. The purpose of this systematic review was to evaluate whether the application of laser therapy improved alveolar healing after tooth extractions. Eight electronic databases were screened: MedLine (PubMed), The Cochrane Library, Web of Science, Scopus, Lilacs, Ibecs, Scielo and BBO. Three reviewers independently assessed the title and abstracts of potentially relevant studies...
October 15, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30320423/electrical-stimulation-disrupts-biofilms-in-a-human-wound-model-and-reveals-the-potential-for-monitoring-treatment-response-with-volatile-biomarkers
#9
Mohammed Ashrafi, Lilyann Novak-Frazer, Julie Morris, Mohamed Baguneid, Riina Rautemaa-Richardson, Ardeshir Bayat
Management of biofilm infections relies on time-consuming laboratory techniques and monitoring treatment by subjective clinical evaluations. Due to these limitations, there is a need to explore alternative strategies. The aims of this study were to assess the feasibility of using volatile organic compound (VOC) biomarkers to monitor treatment response and measure anti-biofilm efficacy of electrical stimulation (ES) in vitro and in human cutaneous wound biofilm models. Staphylococcus aureus (MSSA) and Pseudomonas aeruginosa (PA) biofilms were exposed to ES, ciprofloxacin, or both, with efficacy assessed and quantified by fluorescence staining, enumeration, metabolic assays and biomass quantification; VOCs were measured by gas chromatography-mass spectrometry...
October 15, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30315716/evidence-supporting-wound-care-endpoints-relevant-to-clinical-practice-and-patients-lives-part-2-literature-survey
#10
Vickie R Driver, Lisa J Gould, Peggy Dotson, Latricia L Allen, Marissa J Carter, Laura L Bolton
Patients with wounds bear significant clinical, personal, and economic burdens yet complete wound healing is the only United States Food and Drug Administration (FDA) recognized primary clinical trial endpoint. The overall goal of this project is to work with FDA to expand the list of acceptable primary endpoints, recognizing that new and innovative treatments, devices and drugs may not have complete healing as the focus. Part 1 of the project surveyed 628 wound care experts who identified and content-validated 15 endpoints most relevant to clinical practice and benefitting patients' lives as primary outcomes in clinical trials...
October 13, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30315715/the-altered-mechanical-phenotype-of-fetal-fibroblasts-hinders-myofibroblast-differentiation
#11
Rachel J Jerrell, Mitchell J Leih, Aron Parekh
During the dermal wound healing process, the mechanical rigidity of the newly deposited extracellular matrix and transforming growth factor-β1 promote the transition of fibroblasts into myofibroblasts. Myofibroblasts generate large cellular forces that contract and remodel the extracellular matrix leading to scar formation. In contrast, myofibroblasts are not detected in fetal dermal wounds which are more compliant and contain less transforming growth factor-β1 than adult wounds. Instead, fetal fibroblasts orchestrate scarless healing of dermal wounds resulting in healed tissues that resemble uninjured dermis...
October 13, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30265416/factors-impairing-cell-proliferation-in-the-granulation-tissue-of-pressure-ulcers-impact-of-bacterial-burden
#12
Tomoya Sato, Takahiro Abe, Shigeru Ichioka
The authors aimed to assess the factors that impair cell proliferation in the granulation tissue of pressure ulcers using immunohistochemistry for the cell proliferation marker Ki-67. This was a single center, cross-sectional study. The study included 86 patients with stage III or IV pressure ulcers. Two granulation tissue biopsy specimens were obtained from 86 patients. The specimens were used for histological examination, Ki-67 immunohistochemistry, and bacterial count assessment. The % of Ki-67-stained cells was considered as the Ki-67 index...
September 28, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30264418/topical-nicotinic-receptor-activation-improves-wound-bacterial-infection-outcomes-and-tlr2-mediated-inflammation-in-diabetic-mouse-wounds
#13
Mari Kishibe, Tina M Griffin, Melissa Goslawski, James Sinacore, Sascha A Kristian, Katherine A Radek
The cholinergic anti-inflammatory pathway can directly affect skin antibacterial responses via nicotinic acetylcholine receptors (nAChRs). In particular, α7 nAChR (CHRNA7) present in the epidermis modulates the host response to wounding and/or wound bacterial infection. While physiologic inflammation is required to initiate normal wound repair and can be triggered by Toll-like receptor (TLR) activation, chronic inflammation is frequently observed in diabetic wounds and can occur, in part, via excessive TLR2 activation or production...
September 27, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30252184/ointment-vehicles-regulate-the-wound-healing-process-by-modifying-the-hyaluronan-rich-matrix
#14
Yusuke Murasawa, Katsunori Furuta, Yasuhiro Noda, Hiroyuki Nakamura, Satoshi Fujii, Zenzo Isogai
Topical ointment consists of an active ingredient and vehicle, and the vehicle largely comprises the volume of the ointment. During the treatment of chronic wounds, such as pressure ulcers, the vehicle has been considered inactive, only serving as a carrier of the main pharmaceutical. However, recent reports have indicated that the vehicle has distinct clinical effects that depend on its physicochemical properties. Therefore, an understanding of the action mechanism of the ointment vehicle in wound tissue is necessary...
September 25, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30155987/topical-inhibition-of-puma-signaling-mitigates-radiation-injury
#15
Maria J Kowzun, William J Rifkin, Zachary M Borab, Trevor Ellison, Marc A Soares, Stelios C Wilson, Philip Lotfi, Amey Bandekar, Stavroula Sofou, Pierre B Saadeh, Daniel J Ceradini
Radiation therapy is an effective treatment strategy for many types of cancer but is limited by its side effects on normal tissues, particularly the skin, where persistent and progressive fibrotic changes occur and can impair wound healing. In this study, we attempted to mitigate the effects of irradiation on skin using a novel transcutaneous topical delivery system to locally inhibit p53 up-regulated modulator of apoptosis (PUMA) gene expression with small interfering RNA (siRNA). In an isolated skin irradiation model, the dorsal skin of C57 wild-type mice was irradiated...
August 29, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30152571/deferoxamine-can-prevent-pressure-ulcers-and-accelerate-healing-in-aged-mice
#16
Clark A Bonham, Melanie Rodrigues, Michael Galvez, Artem Trotsyuk, Zachary Stern-Buchbinder, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Chronic wounds are a significant medical and economic problem worldwide. Individuals over the age of 65 are particularly vulnerable to pressure ulcers and impaired wound healing. With this demographic growing rapidly, there is a need for effective treatments. We have previously demonstrated that defective hypoxia signaling through destabilization of the master hypoxia-inducible factor 1α (HIF-1α) underlies impairments in both aging and diabetic wound healing. To stabilize HIF-1α, we developed a transdermal delivery system of the Food and Drug Administration-approved small molecule deferoxamine (DFO) and found that transdermal DFO could both prevent and treat ulcers in diabetic mice...
August 28, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30129080/the-effectiveness-of-hyperbaric-oxygen-therapy-for-healing-chronic-venous-leg-ulcers-a-randomised-double-blind-placebo-controlled-trial
#17
Kenneth R Thistlethwaite, Kathleen J Finlayson, P David Cooper, Bebe Brown, Michael H Bennett, Graeme Kay, Maria T O'Reilly, Helen E Edwards
Over 30% of venous leg ulcers do not heal despite evidence-based treatment. This study aimed to determine the effectiveness of Hyperbaric Oxygen Therapy (HBOT) as an adjunct treatment for non-healing venous leg ulcers. A randomised, double-blind, parallel group, placebo-controlled trial was undertaken in three hyperbaric medicine units. Adults with a venous leg ulcer, Transcutaneous Oxygen Measurement indicative of a hypoxic wound responsive to oxygen challenge, and without contraindications for HBOT; were eligible...
August 21, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30120800/blastema-formation-and-periosteal-ossification-in-the-regenerating-adult-mouse-digit
#18
Lindsay A Dawson, Paula P Schanes, Patrick Kim, Felisha M Imholt, Osama Qureshi, Connor P Dolan, Ling Yu, Mingquan Yan, Katherine N Zimmel, Alyssa R Falck, Ken Muneoka
While mammals cannot regenerate amputated limbs, mice and humans have regenerative ability restricted to amputations transecting the digit tip, including the terminal phalanx (P3). In mice, the regeneration process is epimorphic and mediated by the formation of a blastema comprised of undifferentiated proliferating cells that differentiate to regenerate the amputated structures. Blastema formation distinguishes the regenerative response from a scar-forming healing response. The mouse digit tip serves as a preclinical model to investigate mammalian blastema formation and endogenous regenerative capabilities...
August 18, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30118577/adipose-derived-stem-cells-and-the-stromal-vascular-fraction-in-polyglycolic-acid-collagen-nerve-conduits-promote-rat-facial-nerve-regeneration
#19
Mari Shimizu, Hajime Matsumine, Hironobu Osaki, Yoshifumi Ueta, Satoshi Tsunoda, Wataru Kamei, Kazuki Hashimoto, Yosuke Niimi, Yorikatsu Watanabe, Mariko Miyata, Hiroyuki Sakurai
Adipose-derived stem cells (ADSCs) and the stromal vascular fraction (SVF) promote nerve regeneration. Biodegradable nerve conduits are used to treat peripheral nerve injuries, but their efficiencies are lower than those of autologous nerve grafts. This study developed biodegradable nerve conduits containing ADSCs and SVF and evaluated their facial nerve regenerating abilities in a rat model with a 7-mm nerve defect. SVF and ADSCs were individually poured into nerve conduits with polyglycolic acid-type I collagen as a scaffold (ADSCs and SVF groups)...
August 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30118166/therapeutic-efficacy-of-early-photobiomodulation-therapy-on-the-zones-of-stasis-in-burns-an-experimental-rat-model-study
#20
Jian Jin, Xingfeng Zheng, Fang He, Yongcun Zhang, Hao Zhou, Pengfei Luo, Xiaoyan Hu, Zhaofan Xia
This study aimed to investigate the role of photobiomodulation therapy in preventing zones of stasis in burn wounds. We hypothesized that photobiomodulation therapy could promote tissue formation and release of nitric oxide (NO) through a photochemical reaction, and reduce local inflammatory responses, thereby dilating local microvessels, reducing necrosis and apoptosis. Thirty rats were randomly divided into control (CG) and laser groups (LG) (15 per group). The zone of stasis was formed by applying a hot brass comb to the skin resulting in 4 rectangular burns separated by 3 unburned interspaces...
August 17, 2018: Wound Repair and Regeneration
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