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Wound Repair and Regeneration

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https://www.readbyqxmd.com/read/28090724/efficacy-of-topical-insulin-in-wound-healing-a-preliminary-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Kannan Sridharan, Gowri Sivaramakrishnan
Topical insulin has been shown to promote wound healing in various studies. Considering the absence of a systematic review and quantitative synthesis on the same, the present study was carried out. Using an appropriate search strategy, electronic databases were searched for randomized controlled trials that have compared topical application of insulin in wounds with normal saline. Standardize mean differences were calculated for the following outcome measures: healing rate of ulcers/wound, percent granulation tissue growth, micro vessel density, time to heal, wound area and ulcer severity score...
January 16, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28090711/topical-application-of-nitrosonifedipine-a-novel-radical-scavenger-ameliorates-ischemic-skin-flap-necrosis-in-a-mouse-model
#2
Yutaka Fukunaga, Yuki Izawa-Ishizawa, Yuya Horinouchi, Eriko Sairyo, Yasumasa Ikeda, Keisuke Ishizawa, Koichiro Tsuchiya, Yoshiro Abe, Ichiro Hashimoto, Toshiaki Tamaki
Ischemic skin flap necrosis can occur in random pattern flaps. An excess amount of reactive oxygen species is generated and causes necrosis in the ischemic tissue. Nitrosonifedipine (NO-NIF) has been demonstrated to possess potent radical scavenging ability. However, there has been no study on the effects of NO-NIF on ischemic skin flap necrosis. Therefore, we evaluated the potential of NO-NIF in ameliorating ischemic skin flap necrosis in a mouse model. A random pattern skin flap (1.0 × 3.0 cm) was elevated on the dorsum of C57BL/6 mice...
January 16, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28090708/effect-of-semi-quantitative-culture-results-from-complex-host-surgical-wounds-on-dehiscence-rates
#3
Tammer Elmarsafi, Caitlin S Garwood, John S Steinberg, Karen K Evans, Christopher E Attinger, Paul J Kim
The primary aim of this study was to determine the effect of positive bacterial cultures at the time of closure on dehiscence rates. Pre and post-débridement wound cultures from patients undergoing serial surgical débridement of infected wounds were compared with outcomes 30 days postoperatively. One-hundred patients were enrolled; 35 were excluded for incomplete culture data. Sixty-five patients were evaluated for species counts, including Coagulase negative Staphylococcus, and semi-quantitative culture data for each débridement...
January 16, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28076885/cross-linking-of-porcine-acellular-dermal-matrices-negatively-affects-induced-neovessel-formation-using-platelet-rich-plasma-in-a-rat-model-of-hernia-repair
#4
Joseph S Fernandez-Moure, Jeffrey L Van Eps, Leif Peterson, Beverly A Shirkey, Zachary K Menn, Fernando Cabrera, Azim Karim, Ennio Tasciotti, Bradley K Weiner, Warren A Ellsworth
The degree of crosslinking within acellular dermal matrices (ADM) seems to correlate to neovascularization when used in ventral hernia repair (VHR). Platelet-rich plasma (PRP) enhances wound healing through several mechanisms including neovascularization, but research regarding its effect on soft tissue healing in VHR is lacking. We sought to study the effect of crosslinking on PRP-induced neovascularization in a rodent model of bridging VHR. We hypothesized that ADM crosslinking would negatively affect PRP-induced neovessel formation...
January 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28056485/evidence-of-invasive-and-non-invasive-treatment-modalities-for-hypertrophic-scars-a-systematic-review
#5
Mona Kafka, Vanessa Collins, Lars-Peter Kamolz, Thomas Rappl, Ludwik K Branski, Paul Wurzer
Currently, there are various therapeutic approaches to reduce hypertrophic scarring, however, there is no standard evidence-based treatment protocol. Hence, we performed a systematic review to obtain a summary of the latest clinical trials to evaluate evidence for the treatment of hypertrophic scars. The review protocol was registered and approved by PROSPERO (CRD42015027040). PubMed and Web of Science were searched using predefined MeSH-Terms to identify studies published within the last 10 years regarding treatment for hypertrophic scars...
January 5, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28019718/excretions-secretions-from-medicinal-larvae-lucilia-sericata-inhibit-complement-activation-by-two-mechanisms
#6
Tetsuro Tamura, Gwendolyn Cazander, Suzan H M Rooijakkers, Leendert A Trouw, Peter H Nibbering
Larvae of the blowfly Lucilia sericata facilitate wound healing by removing dead tissue and biofilms from non-healing and necrotic wounds. Another beneficial action of larvae and their excretions/secretions (ES) is down-regulation of excessive inflammation. As prolonged complement activation is key to excessive inflammation, the aim of this study was to elucidate the mechanisms underlying the anti-complement activities of ES. Results revealed that heat sensitive serine proteases in ES degrade multiple complement proteins in all steps of the three complement activation pathways...
December 26, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28019709/exogenous-induction-of-unphosphorylated-pten-reduces-tgf%C3%AE-induced-extracellular-matrix-expressions-in-lung-fibroblasts
#7
Motohiro Kimura, Naozumi Hashimoto, Masaaki Kusunose, Daisuke Aoyama, Koji Sakamoto, Shinichi Miyazaki, Akira Ando, Norihiro Omote, Kazuyoshi Imaizumi, Tsutomu Kawabe, Yoshinori Hasegawa
Transforming growth factor β (TGFβ) plays an important role in regulating aberrant extracellular matrix (ECM) production from alveolar/epithelial cells (AECs) and fibroblasts in pulmonary fibrosis. Although the tumor suppressor gene phosphatase and tensin homologue deleted from chromosome 10 (PTEN) can negatively control many TGFβ-activated signaling pathways via the phosphatase activity, hyperactivation of the TGFβ-related signaling pathways is often observed in fibrosis. Loss of PTEN expression might cause TGFβ-induced ECM production...
December 26, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28019691/biofilm-detection-by-wound-blotting-can-predict-slough-development-in-pressure-ulcers-a-prospective-observational-study
#8
Gojiro Nakagami, Gregory Schultz, Daniel J Gibson, Priscilla Phillips, Aya Kitamura, Takeo Minematsu, Tomomitsu Miyagaki, Akitatsu Hayashi, Sanae Sasaki, Junko Sugama, Hiromi Sanada
Bacteria have been found to form multicellular aggregates which have collectively been termed "biofilms". It is hypothesized that biofilm formation is a means to protect bacterial cells including protection form the immune response of humans. This protective mechanism is believed to explain persistent chronic wound infections. At times, the biofilms are abundant enough to see, and remove by simple wiping. However, recent evidence has shown that the removal of these visible portions are not sufficient, and that biofilms can continue to form even with daily wiping...
December 26, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27997744/a-comparative-outcomes-analysis-evaluating-clinical-effectiveness-in-two-different-human-placental-membrane-products-for-wound-management
#9
Eric L Johnson, James T Marshall, Georgina M Michael
Advances in tissue preservation have led to the commercialization of human placental membranes for the purposes of wound management with each product being characterized by different compositions and properties. The a priori specification of the research question in this investigator-initiated study focused on the clinical outcomes in two nonrandomized, however statistically equal and homogenous patient cohorts receiving either a viable intact cryopreserved human placental membrane (vCPM) or a dehydrated human amnion/chorion membrane (dHACM), for the management of wounds at a single center...
December 20, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27997734/effect-of-botulinum-toxin-a-on-vasoconstriction-and-sympathetic-neurotransmitters-in-a-murine-random-pattern-skin-flap-model
#10
Tai Suk Roh, Bok Ki Jung, Insik Yun, Dae Hyun Lew, Young Seok Kim
Blood supply is the most important factor determining the survival of a skin flap. Botulinum toxin-A (Botox-A) is used as pharmacologic agent not only for aesthetic purposes, but also for its vasomotor actions. This study was conducted to establish whether local application of Botox-A increased survival of random pattern skin flaps in rats by changing the expression of neurotransmitters. Forty adult Sprague-Dawley rats with a caudally-based random pattern skin flap were divided into two groups: Botox-A group and saline group...
December 20, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27997709/the-role-of-allogenic-keratin-derived-dressing-in-wound-healing-in-a-mouse-model
#11
Marek Konop, Dorota Sulejczak, Joanna Czuwara, Piotr Kosson, Aleksandra Misicka, Aandrzej W Lipkowski, Lidia Rudnicka
: Keratin is an interesting protein needed for wound healing and tissue recovery. We have recently proposed a new, simple and inexpensive method to obtain fur and hair keratin-derived biomaterials suitable for medical application. The aim of the study was to evaluate the role of the fur keratin derived protein (FKDP) dressing in the allogenic full-thickness surgical skin wound model. RESULTS: The data obtained using scanning electron microscopy showed that employed processed biomaterial had higher surface porosity compared to control raw material...
December 20, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27987244/aspirin-treatment-for-chronic-wounds-potential-beneficial-and-inhibitory-effects
#12
Ian Andrew Darby, Carolina Dragica Weller
Aspirin is a generally well-tolerated drug that is now widely used in aged patients for its anti-thrombotic action. Aspirin works through several pathways to reduce inflammation, fever and to alter platelet activity. The scientific literature suggests that inhibition of the cyclooxygenase enzymes by aspirin or other nonsteroidal anti-inflammatory drugs may be deleterious to normal wound repair processes and result in healing inhibition. However, novel effects of aspirin on other pathways that regulate inflammation and repair have been reported more recently...
December 17, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27868332/the-transcriptional-responses-of-cultured-wound-cells-to-the-excretions-and-secretions-of-medicinal-lucilia-sericata-larvae
#13
Priscila Dauros Singorenko, Roseanne Rosario, John A Windsor, Anthony R Phillips, Cherie Blenkiron
Maggots, through their excretions and secretions (ES), promote wound healing by removing necrotic tissue, counter bacterial infection, and activate wound associated cells. We investigated the effects of a physiological dose of maggot ES on four wound-associated cell types in vitro with Affymetrix gene expression arrays; keratinocytes, endothelial cells, fibroblasts and monocytes. Keratinocytes showed the fewest (n=5; p<0.05, fold-change ±2) and smallest fold-changes (up to 2.32x) in gene expression and conversely THP1 monocytes had the most (n=233) and greatest magnitude (up to 44...
November 21, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27868279/involvement-of-dpp-iv-cd26-in-cutaneous-wound-healing-process-in-mice
#14
Lara Baticic Pucar, Ester Pernjak Pugel, Dijana Detel, Jadranka Varljen
Dipeptidyl peptidase IV (DPP IV/CD26) is a widely distributed multifunctional protein that plays a significant role in different physiological as well as pathological processes having a broad spectrum of bioactive substrates and immunomodulative properties. It has potential influence on different processes crucial for wound healing, including cell adhesion, migration, apoptosis and extracellular matrix degradation. However, despite its known enzymatic and immunomodulative functions, limited data characterize the role of DPP IV/CD26 in cutaneous wound healing mechanisms...
November 21, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27859922/cadexomer-iodine-provides-superior-efficacy-against-bacterial-wound-biofilms-in-vitro-and-in-vivo
#15
Daniel J Fitzgerald, Paul J Renick, Emma C Forrest, Shannon P Tetens, David N Earnest, Jillian McMillan, Brett M Kiedaisch, Lei Shi, Eric D Roche
Examination of clinical samples indicates bacterial biofilms are present in the majority of chronic wounds, and substantial evidence suggests biofilms contribute significantly to delayed healing. Bacteria in biofilms are highly tolerant of antimicrobials, and little data exist to guide the choice of anti-biofilm wound therapy. Cadexomer iodine (CI) was recently reported to have superior efficacy compared to diverse wound dressings against Pseudomonas aeruginosa biofilms in an ex vivo model. In the current study, the strong performance of CI vs...
November 17, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27865036/relationship-between-opioid-treatment-and-rate-of-healing-in-chronic-wounds
#16
Victoria K Shanmugam, Kara S Couch, Sean McNish, Richard L Amdur
Opioids are routinely used analgesics in patients with chronic wounds; however the impact of opioid exposure on wound healing is poorly understood. The purpose of this study was to investigate the association between opioid exposure and wound outcome in the WE-HEAL study. This longitudinal observational study was conducted on 450 subjects enrolled in the WE-HEAL biorepository. Data were collected prospectively including baseline characteristics, pain score, longitudinal opioid exposure, and total wound surface area (tWSA)...
November 16, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27859908/an-improved-automated-type-based-method-for-area-assessment-of-wound-surface
#17
Xin Qi, Lian Ding, Wenjian Huang, Bing Wen, Xiaohui Guo, Jue Zhang
Accurate and precise wound measurements are a critical component of wound detection and assessment. Digital cameras are convenient and objective tools that are being increasingly used worldwide to assist with wound measurements and assessments. However, heterogeneous wounds and poor lighting conditions continue to be obstacles to wound area recognition. This study therefore provides an improved automated type-based wound area assessment method that is robust to lighting conditions and can distinguish between different wound tissues based on wound colors...
November 14, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27759946/serum-soluble-urokinase-type-plasminogen-activator-receptor-as-a-serum-marker-of-inflammatory-response-that-leads-to-tissue-damage-and-surgical-complication
#18
Emiliano Tognoli, Matteo Luigi Giuseppe Leoni, Daniele Morelli, Elisa Sottotetti, Antonia Martinetti, Stefano Signoroni, Carlotta Galeone, Gianfranco Gallino
Unrestrained activation of the proteolytic systems in anastomotic tissue during repair has been implicated in the pathogenesis of anastomotic leakage. We hypothesized that this mechanism may promote an up-regulation of the urokinase-type plasminogen activator system and a spillover of soluble urokinase-type plasminogen activator receptor (suPAR) into blood. In this retrospective analysis patients with anastomotic leakage were compared with a group of matched uncomplicated patients. Anastomotic leakage complicated patients had significantly higher suPAR (p = 0...
November 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27733020/topical-oxygen-therapy-results-in-complete-wound-healing-in-diabetic-foot-ulcers
#19
Janelle Yu, Suzanne Lu, Ann-Marie McLaren, Julie A Perry, Karen M Cross
Diabetic foot ulcers (DFUs) are a significant problem in an aging population. Fifteen percent of diabetics develop a DFU over their lifetime, which can lead to potential amputation. The 5-year survival rate after amputation is 31%, which is greater than the lifetime risk of mortality from cancer. Topical oxygen is a promising technique for the adjunctive therapy of chronic wounds including DFUs, but few controlled studies exist to support its clinical adoption. The aim of this study was to compare a portable topical oxygen delivery system in patients with nonhealing DFUs to standard best practice...
November 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27733016/the-emerging-role-of-microdialysis-in-diabetic-patients-undergoing-amputation-for-limb-ischemia
#20
Lampros Liasis, George Malietzis, George Galyfos, Thanos Athanasiou, Harry T Papaconstantinou, Fragiska Sigala, Georgios Zografos, Konstantinos Filis
Lower limb ischemia in diabetic patients is a result of macro- and microcirculation dysfunction. Diabetic patients undergoing limb amputation carry high mortality and morbidity rates, and decision making concerning the level of amputation is critical. Aim of this study is to evaluate a novel microdialysis technique to monitor tissue microcirculation preoperatively and predict the success of limb amputation in such patients. Overall, 165 patients with type 2 diabetes mellitus undergoing lower limb amputation were enrolled...
November 2016: Wound Repair and Regeneration
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