journal
MENU ▼
Read by QxMD icon Read
search

Veterinary Research

journal
https://www.readbyqxmd.com/read/29145872/correction-to-a-review-of-virulent-newcastle-disease-viruses-in-the-united-states-and-the-role-of-wild-birds-in-viral-persistence-and-spread
#1
Vienna R Brown, Sarah N Bevins
After publication of the article [1], it has been brought to our attention that Newcastle disease virus was incorrectly labeled as a Tier 1 USDA Select Agent. Newcastle disease virus is a USDA Select Agent but it is not a Tier 1 agent.
November 16, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29137669/blocked-expression-of-key-genes-of-the-angiogenic-pathway-in-jsrv-induced-pulmonary-adenocarcinomas
#2
Maryline Gomes, Fabienne Archer, Nicolas Girard, Barbara Gineys, Christine Dolmazon, Alexandra Bobet Erny, Jean-François Mornex, Caroline Leroux
JSRV (Jaagsiekte Sheep Retrovirus) is a retrovirus inducing a transmissible lung adenocarcinoma in sheep and goats with predominantly lepidic and papillary lesions. This naturally occurring lung cancer in large animals shares many features with human pneumonic-type lung adenocarcinomas with predominant lepidic growth. The metastatic spread is rare in both human and animal cancers. This unique feature prompted us to decipher the angiogenesis pathway in these cancers. We focused on the levels of mRNA and proteins of genes implicated in the extension of JSRV-induced lung adenocarcinomas by studying their expression in lung cancers (n = 10) and normal lungs (n = 10) and in primary epithelial alveolar type II cells derived from cancers (n = 10) or normal lungs (n = 6)...
November 14, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29126442/effect-of-enriched-housing-on-levels-of-natural-auto-antibodies-in-pigs-co-infected-with-porcine-reproductive-and-respiratory-syndrome-virus-prrsv-and-actinobacillus-pleuropneumoniae
#3
Lu Luo, Ingrid Daniëlle Ellen van Dixhoorn, Inonge Reimert, Bas Kemp, Jantina Elizabeth Bolhuis, Hendrik Karel Parmentier
Housing of pigs in barren, stimulus-poor housing conditions may influence their immune status, including antibody responses to (auto-)antigens, and thus affect immune protection, which will influence the onset and outcome of infection. In the present study, we investigated the effects of environmental enrichment versus barren housing on the level of natural (auto-)antibodies (NA(A)b) and their isotypes (IgM and IgG) binding keyhole limpet hemocyanin (KLH), myelin basic protein (MBP), and phosphorycholine conjugated to bovine serum albumin (PC-BSA) in pigs co-infected with porcine reproductive and respiratory syndrome virus (PRRSV) and Actinobacillus pleuropneumoniae (A...
November 10, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29122004/identification-and-characterization-of-serovar-independent-immunogens-in-actinobacillus-pleuropneumoniae
#4
Fabio Antenucci, Cyrielle Fougeroux, Janine T Bossé, Zofia Magnowska, Camille Roesch, Paul Langford, Peter Johannes Holst, Anders Miki Bojesen
Despite numerous actions to prevent disease, Actinobacillus pleuropneumoniae (A. pleuropneumoniae) remains a major cause of porcine pleuropneumonia, resulting in economic losses to the swine industry worldwide. In this paper, we describe the utilization of a reverse vaccinology approach for the selection and in vitro testing of serovar-independent A. pleuropneumoniae immunogens. Potential immunogens were identified in the complete genomes of three A. pleuropneumoniae strains belonging to different serovars using the following parameters: predicted outer-membrane subcellular localization; ≤ 1 trans-membrane helices; presence of a signal peptide in the protein sequence; presence in all known A...
November 9, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29116026/the-c3heb-fej-mouse-model-recapitulates-the-hallmark-of-bovine-tuberculosis-lung-lesions-following-mycobacterium-bovis-aerogenous-infection
#5
Mélodie Bouté, Florence Carreras, Christelle Rossignol, Emilie Doz, Nathalie Winter, Mathieu Epardaud
Achieving the control of bovine tuberculosis (bTB) would require the discovery of an efficient combined immunodiagnostic and vaccine strategy. Since in vivo experiments on cattle are not ethically and economically acceptable there is a need for a cost-effective animal model capable of reproducing, as closely as possible, the physiopathology of bTB to (i) better characterize the cellular and molecular features of bTB immunopathogenesis and (ii) screen preclinical vaccine candidates. To develop such a model, we focused on the C3HeB/FeJ Kramnik's mouse forming hypoxic, encapsulated granulomas with a caseous necrotic center following Mycobacterium tuberculosis infection...
November 7, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29096717/variability-in-the-response-of-canine-and-human-dendritic-cells-stimulated-with-brucella-canis
#6
Myriam Pujol, Francisca Castillo, Carla Alvarez, Camila Rojas, Consuelo Borie, Arturo Ferreira, Rolando Vernal
Brucella canis is a small intracellular Gram-negative bacterium whose primary host is the dog, but it also can cause mild human brucellosis. One of the main causes of an inefficient immune response against other species of Brucella is their interaction with dendritic cells (DCs), which affects antigen presentation and impairs the development of an effective Th1 immune response. This study analysed the cytokine pattern production, by RT-qPCR and ELISA, in human and canine DCs against whole B. canis or its purified LPS...
November 2, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29096712/crosstalk-between-h9n2-avian-influenza-virus-and-crypt-derived-intestinal-organoids
#7
Lulu Huang, Qihang Hou, Lulu Ye, Qian Yang, Qinghua Yu
The spread of Avian influenza virus via animal feces makes the virus difficult to prevent, which causes great threat to human health. Therefore, it is imperative to understand the survival and invasion mechanism of H9N2 virus in the intestinal mucosa. In this study, we used mouse threedimensional intestinal organoids that contained intestinal crypts and villi differentiated from intestinal stem cells to explore interactions between H9N2 avian influenza virus and the intestinal mucosa. The HA, NA, NP and PB1 genes of H9N2 viruses could be detected in intestinal organoids at 1 h, and reached peak levels at 48 h post-infection...
November 2, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29080562/large-scale-lagovirus-disease-outbreaks-in-european-brown-hares-lepus-europaeus-in-france-caused-by-rhdv2-strains-spatially-shared-with-rabbits-oryctolagus-cuniculus
#8
Ghislaine Le Gall-Reculé, Evelyne Lemaitre, Stéphane Bertagnoli, Céline Hubert, Sokunthea Top, Anouk Decors, Stéphane Marchandeau, Jean-Sébastien Guitton
Rabbit haemorrhagic disease virus (RHDV) is a lagovirus that causes rabbit haemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus). In 2010, a new genotype called RHDV2 emerged in France. It exhibits a larger host range than classical RHDV strains by sporadically infecting different hare species, including the European hare (Lepus europaeus). Phylogenetic analyses revealed that closely related RHDV2 strains circulate locally in both hares and rabbits, and therefore that RHDV2 strains infecting hares do not belong to a lineage that has evolved only in this species...
October 28, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29073936/evaluation-of-the-efficacy-of-a-commercial-inactivated-genogroup-2b-based-porcine-epidemic-diarrhea-virus-pedv-vaccine-and-experimental-live-genogroup-1b-exposure-against-2b-challenge
#9
Tanja Opriessnig, Priscilla F Gerber, Huigang Shen, Alessandra Marnie M G de Castro, Jianqiang Zhang, Qi Chen, Patrick Halbur
Porcine epidemic diarrhea virus strains from the G1b cluster are considered less pathogenic compared to the G2b cluster. The aim of this study was to compare the ability of G1b-based live virus exposure against use of a commercial G2b-based inactivated vaccine to protect growing pigs against G2b challenge. Thirty-nine PEDV naïve pigs were randomly divided into five groups: EXP-IM-1b (intramuscular G1b exposure; G2b challenge), EXP-ORAL-1b (oral G1b exposure; G2b challenge), VAC-IM-2b (intramuscular commercial inactivated G2b vaccination; G2b challenge), POS-CONTROL (sham-vaccination; G2b challenge) and NEG-CONTROL (sham-vaccination; sham-challenge)...
October 26, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29073919/a-review-of-virulent-newcastle-disease-viruses-in-the-united-states-and-the-role-of-wild-birds-in-viral-persistence-and-spread
#10
REVIEW
Vienna R Brown, Sarah N Bevins
Newcastle disease is caused by virulent strains of Newcastle disease virus (NDV), which causes substantial morbidity and mortality events worldwide in poultry. The virus strains can be differentiated as lentogenic, mesogenic, or velogenic based on a mean death time in chicken embryos. Currently, velogenic strains of NDV are not endemic in United States domestic poultry; however, these strains are present in other countries and are occasionally detected in wild birds in the U.S. A viral introduction into domestic poultry could have severe economic consequences due to the loss of production from sick and dying birds, the cost of control measures such as depopulation and disinfection measures, and the trade restrictions that would likely be imposed as a result of an outbreak...
October 26, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29070065/salmonella-typhimurium-the-major-causative-agent-of-foodborne-illness-inactivated-by-a-phage-lysis-system-provides-effective-protection-against-lethal-challenge-by-induction-of-robust-cell-mediated-immune-responses-and-activation-of-dendritic-cells
#11
Gayeon Won, John Hwa Lee
Salmonella Typhimurium infection via foodborne transmission remains a major public health threat even in developed countries. Vaccines have been developed to reduce the disease burden at the pre-harvest stage, but the cell-mediated immune response against intracellular invasion of the pathogen is not sufficiently elicited by conventional killed Salmonella vaccines, which are safer than live vaccines. In this study, we developed a genetically inactivated vaccine candidate by introducing lysis plasmid pJHL454 harboring the λ phage holin-endolysin system into S...
October 25, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29070059/synergistic-effect-of-pb2-283m-and-526r-contributes-to-enhanced-virulence-of-h5n8-influenza-viruses-in-mice
#12
Xiao Wang, Sujuan Chen, Dandan Wang, Xixin Zha, Siwen Zheng, Tao Qin, Wenjun Ma, Daxin Peng, Xiufan Liu
Highly pathogenic avian influenza (HPAI) H5N8 virus has caused considerable economic losses to poultry industry and poses a great threat to public health. Our previous study revealed two genetically similar HPAI H5N8 viruses displaying completely different virulence in mice. However, the molecular basis for viral pathogenicity to mammals remains unknown. Herein, we generated a series of reassortants between the two viruses and evaluated their virulence in mice. We demonstrated that 283M in PB2 is a new mammalian virulence marker for H5 viruses and that synergistic effect of amino acid residues 283M and 526R in PB2 is responsible for high virulence of the HPAI H5N8 virus...
October 25, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29037262/molecular-and-virulence-characterization-of-highly-prevalent-streptococcus-agalactiae-circulated-in-bovine-dairy-herds
#13
Maoda Pang, Lichang Sun, Tao He, Hongdu Bao, Lili Zhang, Yan Zhou, Hui Zhang, Ruicheng Wei, Yongjie Liu, Ran Wang
Bovine mastitis caused by Streptococcus agalactiae continues to be one of the major veterinary and economic issues in certain areas of the world. The more prevalent S. agalactiae strains that cause bovine mastitis in China dairy farms belong to a number of bovine-adapted sequence types (STs) ST67, ST103 and ST568. However, it is unknown why these STs can emerge as highly prevalent clones in bovine dairy farms. Here, to determine if a variety of virulence characteristics were associated with these highly prevalent STs, the molecular and virulence characterization of 116 strains isolated from bovine, human, fish and environment were analyzed...
October 16, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29017611/amplicon-sequencing-of-bacterial-microbiota-in-abortion-material-from-cattle
#14
Sara Vidal, Kristel Kegler, Horst Posthaus, Vincent Perreten, Sabrina Rodriguez-Campos
Abortions in cattle have a significant economic impact on animal husbandry and require prompt diagnosis for surveillance of epizootic infectious agents. Since most abortions are not epizootic but sporadic with often undetected etiologies, this study examined the bacterial community present in the placenta (PL, n = 32) and fetal abomasal content (AC, n = 49) in 64 cases of bovine abortion by next generation sequencing (NGS) of the 16S rRNA gene. The PL and AC from three fetuses of dams that died from non-infectious reasons were included as controls...
October 10, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29017603/longitudinal-study-of-influenza-a-virus-circulation-in-a-nursery-swine-barn
#15
Juliana B Ferreira, Helena Grgić, Robert Friendship, Greg Wideman, Éva Nagy, Zvonimir Poljak
Commercial production of swine often involves raising animals in large groups through the use of multi-stage production systems. In such systems, pigs can experience different degrees of contact with animals of the same or different ages. Population size and degree of contact can greatly influence transmission of endemic pathogens, including influenza A virus (IAV). IAV can display high genetic variability, which can further complicate population-level patterns. Yet, the IAV transmission in large multi-site swine production systems has not been well studied...
October 10, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29017553/which-phenotypic-traits-of-resistance-should-be-improved-in-cattle-to-control-paratuberculosis-dynamics-in-a-dairy-herd-a-modelling-approach
#16
Racem Ben Romdhane, Gaël Beaunée, Guillaume Camanes, Raphaël Guatteo, Christine Fourichon, Pauline Ezanno
Paratuberculosis is a worldwide disease causing production losses in dairy cattle herds. Variability of cattle response to exposure to Mycobacterium avium subsp. paratuberculosis (Map) has been highlighted. Such individual variability could influence Map spread at larger scale. Cattle resistance to paratuberculosis has been shown to be heritable, suggesting genetic selection could enhance disease control. Our objective was to identify which phenotypic traits characterising the individual course of infection influence Map spread in a dairy cattle herd...
October 10, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28985754/cross-protective-immune-responses-in-nursing-piglets-infected-with-a-us-spike-insertion-deletion-porcine-epidemic-diarrhea-virus-strain-and-challenged-with-an-original-us-pedv-strain
#17
Thavamathi Annamalai, Chun-Ming Lin, Xiang Gao, Xinsheng Liu, Zhongyan Lu, Linda J Saif, Qiuhong Wang
We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20-29 days post-inoculation (dpi), all pigs were challenged with the PC21A strain. The S-INDEL-inoculated pigs had lower ileal IgA antibody secreting cells, serum IgA and neutralizing antibody titers compared with PC21A-inoculated pigs. No pigs in the PC21A-group developed diarrhea, whereas 81 and 100% of pigs in the S-INDEL and mock-groups had diarrhea post challenge, respectively...
October 6, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28982390/limitations-of-using-feline-coronavirus-spike-protein-gene-mutations-to-diagnose-feline-infectious-peritonitis
#18
Emily N Barker, Angelica Stranieri, Chris R Helps, Emily L Porter, Andrew D Davidson, Michael J Day, Toby Knowles, Anja Kipar, Séverine Tasker
Feline infectious peritonitis (FIP) is a fatal disease of cats, and a sequela of systemic feline coronavirus (FCoV) infection. Mutations in the viral spike (S) gene have been associated with FCoVs found in tissues from cats with FIP, but not FCoVs found in faeces from healthy cats, and are implicated in monocyte/macrophage tropism and systemic spread. This study was designed to determine whether S gene mutation analysis can reliably diagnose FIP. Cats were categorised as with FIP (n = 57) or without FIP (n = 45) based on gross post-mortem and histopathological examination including immunohistochemistry for FCoV antigen...
October 5, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28982389/an-avirulent-brachyspira-hyodysenteriae-strain-elicits-intestinal-iga-and-slows-down-spread-of-swine-dysentery
#19
Maxime Mahu, Filip Boyen, Stefano Canessa, Jackeline Zavala Marchan, Freddy Haesebrouck, An Martel, Frank Pasmans
Swine dysentery caused by Brachyspira hyodysenteriae, results in substantial economic losses in swine producing countries worldwide. Although a number of different vaccine approaches have been explored with regard to this disease, they show limitations and none of them have reached the market. We here determine the vaccine potential of a weakly haemolytic B. hyodysenteriae strain. The virulence of this strain was assessed in experimental infection trials and its protection against swine dysentery was quantified in a vaccination-challenge experiment using a seeder infection model...
October 5, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28974251/control-of-endemic-swine-flu-persistence-in-farrow-to-finish-pig-farms-a-stochastic-metapopulation-modeling-assessment
#20
Charlie Cador, Mathieu Andraud, Lander Willem, Nicolas Rose
Swine influenza viruses (swIAVs) are known to persist endemically in farrow-to-finish pig farms, leading to repeated swine flu outbreaks in successive batches of pigs at a similar age (mostly around 8 weeks of age). This persistence in European swine herds involves swIAVs from European lineages including H1avN1, H1huN2, H3N2, the 2009 H1N1 pandemic virus and their reassortants. The specific population dynamics of farrow-to-finish pig farms, the immune status of the animals at infection-time, the co-circulation of distinct subtypes leading to consecutive or concomitant infections have been evidenced as factors favouring swIAV persistence within herds...
October 3, 2017: Veterinary Research
journal
journal
31381
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"